Tag Archives: therapy
#435793 Tiny Robots Carry Stem Cells Through a ...
Engineers have built microrobots to perform all sorts of tasks in the body, and can now add to that list another key skill: delivering stem cells. In a paper published today in Science Robotics, researchers describe propelling a magnetically-controlled, stem-cell-carrying bot through a live mouse.
Under a rotating magnetic field, the microrobots moved with rolling and corkscrew-style locomotion. The researchers, led by Hongsoo Choi and his team at the Daegu Gyeongbuk Institute of Science & Technology (DGIST), in South Korea, also demonstrated their bot’s moves in slices of mouse brain, in blood vessels isolated from rat brains, and in a multi-organ-on-a chip.
The invention provides an alternative way to deliver stem cells, which are increasingly important in medicine. Such cells can be coaxed into becoming nearly any kind of cell, making them great candidates for treating neurodegenerative disorders such as Alzheimer’s.
But delivering stem cells typically requires an injection with a needle, which lowers the survival rate of the stem cells, and limits their reach in the body. Microrobots, however, have the potential to deliver stem cells to precise, hard-to-reach areas, with less damage to surrounding tissue, and better survival rates, says Jin-young Kim, a principle investigator at DGIST-ETH Microrobotics Research Center, and an author on the paper.
The virtues of microrobots have inspired several research groups to propose and test different designs in simple conditions, such as microfluidic channels and other static environments. A group out of Hong Kong last year described a burr-shaped bot that carried cells through live, transparent zebrafish.
The new research presents a magnetically-actuated microrobot that successfully carried stem cells through a live mouse. In additional experiments, the cells, which had differentiated into brain cells such as astrocytes, oligodendrocytes, and neurons, transferred to microtissues on the multi-organ-on-a-chip. Taken together, the proof-of-concept experiments demonstrate the potential for microrobots to be used in human stem cell therapy, says Kim.
The team fabricated the robots with 3D laser lithography, and designed them in two shapes: spherical and helical. Using a rotating magnetic field, the scientists navigated the spherical-shaped bots with a rolling motion, and the helical bots with a corkscrew motion. These styles of locomotion proved more efficient than that from a simple pulling force, and were more suitable for use in biological fluids, the scientists reported.
The big challenge in navigating microbots in a live animal (or human body) is being able to see them in real time. Imaging with fMRI doesn’t work, because the magnetic fields interfere with the system. “To precisely control microbots in vivo, it is important to actually see them as they move,” the authors wrote in their paper.
That wasn’t possible during experiments in a live mouse, so the researchers had to check the location of the microrobots before and after the experiments using an optical tomography system called IVIS. They also had to resort to using a pulling force with a permanent magnet to navigate the microrobots inside the mouse, due to the limitations of the IVIS system.
Kim says he and his colleagues are developing imaging systems that will enable them to view in real time the locomotion of their microrobots in live animals. Continue reading
Posted in Human Robots
#435687 Humanoid Robots Teach Coping Skills to ...
Photo: Rob Felt
IEEE Senior Member Ayanna Howard with one of the interactive androids that help children with autism improve their social and emotional engagement.
THE INSTITUTEChildren with autism spectrum disorder can have a difficult time expressing their emotions and can be highly sensitive to sound, sight, and touch. That sometimes restricts their participation in everyday activities, leaving them socially isolated. Occupational therapists can help them cope better, but the time they’re able to spend is limited and the sessions tend to be expensive.
Roboticist Ayanna Howard, an IEEE senior member, has been using interactive androids to guide children with autism on ways to socially and emotionally engage with others—as a supplement to therapy. Howard is chair of the School of Interactive Computing and director of the Human-Automation Systems Lab at Georgia Tech. She helped found Zyrobotics, a Georgia Tech VentureLab startup that is working on AI and robotics technologies to engage children with special needs. Last year Forbes named Howard, Zyrobotics’ chief technology officer, one of the Top 50 U.S. Women in Tech.
In a recent study, Howard and other researchers explored how robots might help children navigate sensory experiences. The experiment involved 18 participants between the ages of 4 and 12; five had autism, and the rest were meeting typical developmental milestones. Two humanoid robots were programmed to express boredom, excitement, nervousness, and 17 other emotional states. As children explored stations set up for hearing, seeing, smelling, tasting, and touching, the robots modeled what the socially acceptable responses should be.
“If a child’s expression is one of happiness or joy, the robot will have a corresponding response of encouragement,” Howard says. “If there are aspects of frustration or sadness, the robot will provide input to try again.” The study suggested that many children with autism exhibit stronger levels of engagement when the robots interact with them at such sensory stations.
It is one of many robotics projects Howard has tackled. She has designed robots for researching glaciers, and she is working on assistive robots for the home, as well as an exoskeleton that can help children who have motor disabilities.
Howard spoke about her work during the Ethics in AI: Impacts of (Anti?) Social Robotics panel session held in May at the IEEE Vision, Innovation, and Challenges Summit in San Diego. You can watch the session on IEEE.tv.
The next IEEE Vision, Innovation, and Challenges Summit and Honors Ceremony will be held on 15 May 2020 at the JW Marriott Parq Vancouver hotel, in Vancouver.
In this interview with The Institute, Howard talks about how she got involved with assistive technologies, the need for a more diverse workforce, and ways IEEE has benefited her career.
FOCUS ON ACCESSIBILITY
Howard was inspired to work on technology that can improve accessibility in 2008 while teaching high school students at a summer camp devoted to science, technology, engineering, and math.
“A young lady with a visual impairment attended camp. The robot programming tools being used at the camp weren’t accessible to her,” Howard says. “As an engineer, I want to fix problems when I see them, so we ended up designing tools to enable access to programming tools that could be used in STEM education.
“That was my starting motivation, and this theme of accessibility has expanded to become a main focus of my research. One of the things about this world of accessibility is that when you start interacting with kids and parents, you discover another world out there of assistive technologies and how robotics can be used for good in education as well as therapy.”
DIVERSITY OF THOUGHT
The Institute asked Howard why it’s important to have a more diverse STEM workforce and what could be done to increase the number of women and others from underrepresented groups.
“The makeup of the current engineering workforce isn’t necessarily representative of the world, which is composed of different races, cultures, ages, disabilities, and socio-economic backgrounds,” Howard says. “We’re creating products used by people around the globe, so we have to ensure they’re being designed for a diverse population. As IEEE members, we also need to engage with people who aren’t engineers, and we don’t do that enough.”
Educational institutions are doing a better job of increasing diversity in areas such as gender, she says, adding that more work is needed because the enrollment numbers still aren’t representative of the population and the gains don’t necessarily carry through after graduation.
“There has been an increase in the number of underrepresented minorities and females going into engineering and computer science,” she says, “but data has shown that their numbers are not sustained in the workforce.”
ROLE MODEL
Because there are more underrepresented groups on today’s college campuses that can form a community, the lack of engineering role models—although a concern on campuses—is more extreme for preuniversity students, Howard says.
“Depending on where you go to school, you may not know what an engineer does or even consider engineering as an option,” she says, “so there’s still a big disconnect there.”
Howard has been involved for many years in math- and science-mentoring programs for at-risk high school girls. She tells them to find what they’re passionate about and combine it with math and science to create something. She also advises them not to let anyone tell them that they can’t.
Howard’s father is an engineer. She says he never encouraged or discouraged her to become one, but when she broke something, he would show her how to fix it and talk her through the process. Along the way, he taught her a logical way of thinking she says all engineers have.
“When I would try to explain something, he would quiz me and tell me to ‘think more logically,’” she says.
Howard earned a bachelor’s degree in engineering from Brown University, in Providence, R.I., then she received both a master’s and doctorate degree in electrical engineering from the University of Southern California. Before joining the faculty of Georgia Tech in 2005, she worked at NASA’s Jet Propulsion Laboratory at the California Institute of Technology for more than a decade as a senior robotics researcher and deputy manager in the Office of the Chief Scientist.
ACTIVE VOLUNTEER
Howard’s father was also an IEEE member, but that’s not why she joined the organization. She says she signed up when she was a student because, “that was something that you just did. Plus, my student membership fee was subsidized.”
She kept the membership as a grad student because of the discounted rates members receive on conferences.
Those conferences have had an impact on her career. “They allow you to understand what the state of the art is,” she says. “Back then you received a printed conference proceeding and reading through it was brutal, but by attending it in person, you got a 15-minute snippet about the research.”
Howard is an active volunteer with the IEEE Robotics and Automation and the IEEE Systems, Man, and Cybernetics societies, holding many positions and serving on several committees. She is also featured in the IEEE Impact Creators campaign. These members were selected because they inspire others to innovate for a better tomorrow.
“I value IEEE for its community,” she says. “One of the nice things about IEEE is that it’s international.” Continue reading
Posted in Human Robots
#435520 These Are the Meta-Trends Shaping the ...
Life is pretty different now than it was 20 years ago, or even 10 years ago. It’s sort of exciting, and sort of scary. And hold onto your hat, because it’s going to keep changing—even faster than it already has been.
The good news is, maybe there won’t be too many big surprises, because the future will be shaped by trends that have already been set in motion. According to Singularity University co-founder and XPRIZE founder Peter Diamandis, a lot of these trends are unstoppable—but they’re also pretty predictable.
At SU’s Global Summit, taking place this week in San Francisco, Diamandis outlined some of the meta-trends he believes are key to how we’ll live our lives and do business in the (not too distant) future.
Increasing Global Abundance
Resources are becoming more abundant all over the world, and fewer people are seeing their lives limited by scarcity. “It’s hard for us to realize this as we see crisis news, but what people have access to is more abundant than ever before,” Diamandis said. Products and services are becoming cheaper and thus available to more people, and having more resources then enables people to create more, thus producing even more resources—and so on.
Need evidence? The proportion of the world’s population living in extreme poverty is currently lower than it’s ever been. The average human life expectancy is longer than it’s ever been. The costs of day-to-day needs like food, energy, transportation, and communications are on a downward trend.
Take energy. In most of the world, though its costs are decreasing, it’s still a fairly precious commodity; we turn off our lights and our air conditioners when we don’t need them (ideally, both to save money and to avoid wastefulness). But the cost of solar energy has plummeted, and the storage capacity of batteries is improving, and solar technology is steadily getting more efficient. Bids for new solar power plants in the past few years have broken each other’s records for lowest cost per kilowatt hour.
“We’re not far from a penny per kilowatt hour for energy from the sun,” Diamandis said. “And if you’ve got energy, you’ve got water.” Desalination, for one, will be much more widely feasible once the cost of the energy needed for it drops.
Knowledge is perhaps the most crucial resource that’s going from scarce to abundant. All the world’s knowledge is now at the fingertips of anyone who has a mobile phone and an internet connection—and the number of people connected is only going to grow. “Everyone is being connected at gigabit connection speeds, and this will be transformative,” Diamandis said. “We’re heading towards a world where anyone can know anything at any time.”
Increasing Capital Abundance
It’s not just goods, services, and knowledge that are becoming more plentiful. Money is, too—particularly money for business. “There’s more and more capital available to invest in companies,” Diamandis said. As a result, more people are getting the chance to bring their world-changing ideas to life.
Venture capital investments reached a new record of $130 billion in 2018, up from $84 billion in 2017—and that’s just in the US. Globally, VC funding grew 21 percent from 2017 to a total of $207 billion in 2018.
Through crowdfunding, any person in any part of the world can present their idea and ask for funding. That funding can come in the form of a loan, an equity investment, a reward, or an advanced purchase of the proposed product or service. “Crowdfunding means it doesn’t matter where you live, if you have a great idea you can get it funded by people from all over the world,” Diamandis said.
All this is making a difference; the number of unicorns—privately-held startups valued at over $1 billion—currently stands at an astounding 360.
One of the reasons why the world is getting better, Diamandis believes, is because entrepreneurs are trying more crazy ideas—not ideas that are reasonable or predictable or linear, but ideas that seem absurd at first, then eventually end up changing the world.
Everyone and Everything, Connected
As already noted, knowledge is becoming abundant thanks to the proliferation of mobile phones and wireless internet; everyone’s getting connected. In the next decade or sooner, connectivity will reach every person in the world. 5G is being tested and offered for the first time this year, and companies like Google, SpaceX, OneWeb, and Amazon are racing to develop global satellite internet constellations, whether by launching 12,000 satellites, as SpaceX’s Starlink is doing, or by floating giant balloons into the stratosphere like Google’s Project Loon.
“We’re about to reach a period of time in the next four to six years where we’re going from half the world’s people being connected to the whole world being connected,” Diamandis said. “What happens when 4.2 billion new minds come online? They’re all going to want to create, discover, consume, and invent.”
And it doesn’t stop at connecting people. Things are becoming more connected too. “By 2020 there will be over 20 billion connected devices and more than one trillion sensors,” Diamandis said. By 2030, those projections go up to 500 billion and 100 trillion. Think about it: there’s home devices like refrigerators, TVs, dishwashers, digital assistants, and even toasters. There’s city infrastructure, from stoplights to cameras to public transportation like buses or bike sharing. It’s all getting smart and connected.
Soon we’ll be adding autonomous cars to the mix, and an unimaginable glut of data to go with them. Every turn, every stop, every acceleration will be a data point. Some cars already collect over 25 gigabytes of data per hour, Diamandis said, and car data is projected to generate $750 billion of revenue by 2030.
“You’re going to start asking questions that were never askable before, because the data is now there to be mined,” he said.
Increasing Human Intelligence
Indeed, we’ll have data on everything we could possibly want data on. We’ll also soon have what Diamandis calls just-in-time education, where 5G combined with artificial intelligence and augmented reality will allow you to learn something in the moment you need it. “It’s not going and studying, it’s where your AR glasses show you how to do an emergency surgery, or fix something, or program something,” he said.
We’re also at the beginning of massive investments in research working towards connecting our brains to the cloud. “Right now, everything we think, feel, hear, or learn is confined in our synaptic connections,” Diamandis said. What will it look like when that’s no longer the case? Companies like Kernel, Neuralink, Open Water, Facebook, Google, and IBM are all investing billions of dollars into brain-machine interface research.
Increasing Human Longevity
One of the most important problems we’ll use our newfound intelligence to solve is that of our own health and mortality, making 100 years old the new 60—then eventually, 120 or 150.
“Our bodies were never evolved to live past age 30,” Diamandis said. “You’d go into puberty at age 13 and have a baby, and by the time you were 26 your baby was having a baby.”
Seeing how drastically our lifespans have changed over time makes you wonder what aging even is; is it natural, or is it a disease? Many companies are treating it as one, and using technologies like senolytics, CRISPR, and stem cell therapy to try to cure it. Scaffolds of human organs can now be 3D printed then populated with the recipient’s own stem cells so that their bodies won’t reject the transplant. Companies are testing small-molecule pharmaceuticals that can stop various forms of cancer.
“We don’t truly know what’s going on inside our bodies—but we can,” Diamandis said. “We’re going to be able to track our bodies and find disease at stage zero.”
Chins Up
The world is far from perfect—that’s not hard to see. What’s less obvious but just as true is that we’re living in an amazing time. More people are coming together, and they have more access to information, and that information moves faster, than ever before.
“I don’t think any of us understand how fast the world is changing,” Diamandis said. “Most people are fearful about the future. But we should be excited about the tools we now have to solve the world’s problems.”
Image Credit: spainter_vfx / Shutterstock.com Continue reading
Posted in Human Robots