Tag Archives: personality

#439095 DARPA Prepares for the Subterranean ...

The DARPA Subterranean Challenge Final Event is scheduled to take place at the Louisville Mega Cavern in Louisville, Kentucky, from September 21 to 23. We’ve followed SubT teams as they’ve explored their way through abandoned mines, unfinished nuclear reactors, and a variety of caves, and now everything comes together in one final course where the winner of the Systems Track will take home the $2 million first prize.

It’s a fitting reward for teams that have been solving some of the hardest problems in robotics, but winning isn’t going to be easy, and we’ll talk with SubT Program Manager Tim Chung about what we have to look forward to.

Since we haven’t talked about SubT in a little while (what with the unfortunate covid-related cancellation of the Systems Track Cave Circuit), here’s a quick refresher of where we are: the teams have made it through the Tunnel Circuit, the Urban Circuit, and a virtual version of the Cave Circuit, and some of them have been testing in caves of their own. The Final Event will include all of these environments, and the teams of robots will have 60 minutes to autonomously map the course, locating artifacts to score points. Since I’m not sure where on Earth there’s an underground location that combines tunnels and caves with urban structures, DARPA is going to have to get creative, and the location in which they’ve chosen to do that is Louisville, Kentucky.

The Louisville Mega Cavern is a former limestone mine, most of which is under the Louisville Zoo. It’s not all that deep, mostly less than 30 meters under the surface, but it’s enormous: with 370,000 square meters of rooms and passages, the cavern currently hosts (among other things) a business park, a zipline course, and mountain bike trails, because why not. While DARPA is keeping pretty quiet on the details, I’m guessing that they’ll be taking over a chunk of the cavern and filling it with features representing as many of the environmental challenges as they can.

To learn more about how the SubT Final Event is going to go, we spoke with SubT Program Manager Tim Chung. But first, we talked about Tim’s perspective on the success of the Urban Circuit, and how teams have been managing without an in-person Cave Circuit.

IEEE Spectrum: How did the SubT Urban Circuit go?

Tim Chung: On a couple fronts, Urban Circuit was really exciting. We were in this unfinished nuclear power plant—I’d be surprised if any of the competitors had prior experience in such a facility, or anything like it. I think that was illuminating both from an experiential point of view for the competitors, but also from a technology point of view, too.

One thing that I thought was really interesting was that we, DARPA, didn't need to make the venue more challenging. The real world is really that hard. There are places that were just really heinous for these robots to have to navigate through in order to look in every nook and cranny for artifacts. There were corners and doorways and small corridors and all these kind of things that really forced the teams to have to work hard, and the feedback was, why did DARPA have to make it so hard? But we didn’t, and in fact there were places that for the safety of the robots and personnel, we had to ensure the robots couldn’t go.

It sounds like some teams thought this course was on the more difficult side—do you think you tuned it to just the right amount of DARPA-hard?

Our calibration worked quite well. We were able to tease out and help refine and better understand what technologies are both useful and critical and also those technologies that might not necessarily get you the leap ahead capability. So as an example, the Urban Circuit really emphasized verticality, where you have to be able to sense, understand, and maneuver in three dimensions. Being able to capitalize on their robot technologies to address that verticality really stratified the teams, and showed how critical those capabilities are.

We saw teams that brought a lot of those capabilities do very well, and teams that brought baseline capabilities do what they could on the single floor that they were able to operate on. And so I think we got the Goldilocks solution for Urban Circuit that combined both difficulty and ambition.

Photos: Evan Ackerman/IEEE Spectrum

Two SubT Teams embedded networking equipment in balls that they could throw onto the course.

One of the things that I found interesting was that two teams independently came up with throwable network nodes. What was DARPA’s reaction to this? Is any solution a good solution, or was it more like the teams were trying to game the system?

You mean, do we want teams to game the rules in any way so as to get a competitive advantage? I don't think that's what the teams were doing. I think they were operating not only within the bounds of the rules, which permitted such a thing as throwable sensors where you could stand at the line and see how far you could chuck these things—not only was that acceptable by the rules, but anticipated. Behind the scenes, we tried to do exactly what these teams are doing and think through different approaches, so we explicitly didn't forbid such things in our rules because we thought it's important to have as wide an aperture as possible.

With these comms nodes specifically, I think they’re pretty clever. They were in some cases hacked together with a variety of different sports paraphernalia to see what would provide the best cushioning. You know, a lot of that happens in the field, and what it captured was that sometimes you just need to be up at two in the morning and thinking about things in a slightly different way, and that's when some nuggets of innovation can arise, and we see this all the time with operators in the field as well. They might only have duct tape or Styrofoam or whatever the case may be and that's when they come up with different ways to solve these problems. I think from DARPA’s perspective, and certainly from my perspective, wherever innovation can strike, we want to try to encourage and inspire those opportunities. I thought it was great, and it’s all part of the challenge.

Is there anything you can tell us about what your original plan had been for the Cave Circuit?

I can say that we’ve had the opportunity to go through a number of these caves scattered all throughout the country, and engage with caving communities—cavers clubs, speleologists that conduct research, and then of course the cave rescue community. The single biggest takeaway
is that every cave, and there are tens of thousands of them in the US alone, every cave has its own personality, and a lot of that personality is quite hidden from humans, because we can’t explore or access all of the cave. This led us to a number of different caves that were intriguing from a DARPA perspective but also inspirational for our Cave Circuit Virtual Competition.

How do you feel like the tuning was for the Virtual Cave Circuit?

The Virtual Competition, as you well know, was exciting in the sense that we could basically combine eight worlds into one competition, whereas the systems track competition really didn’t give us that opportunity. Even if we were able have held the Cave Circuit Systems Competition in person, it would have been at one site, and it would have been challenging to represent the level of diversity that we could with the Virtual Competition. So I think from that perspective, it’s clearly an advantage in terms of calibration—diversity gets you the ability to aggregate results to capture those that excel across all worlds as well as those that do well in one world or some worlds and not the others. I think the calibration was great in the sense that we were able to see the gamut of performance. Those that did well, did quite well, and those that have room to grow showed where those opportunities are for them as well.

We had to find ways to capture that diversity and that representativeness, and I think one of the fun ways we did that was with the different cave world tiles that we were able to combine in a variety of different ways. We also made use of a real world data set that we were able to take from a laser scan. Across the board, we had a really great chance to illustrate why virtual testing and simulation still plays such a dominant role in robotics technology development, and why I think it will continue to play an increasing role for developing these types of autonomy solutions.

Photo: Team CSIRO Data 61

How can systems track teams learn from their testing in whatever cave is local to them and effectively apply that to whatever cave environment is part of the final considering what the diversity of caves is?

I think that hits the nail on the head for what we as technologists are trying to discover—what are the transferable generalizable insights and how does that inform our technology development? As roboticists we want to optimize our systems to perform well at the tasks that they were designed to do, and oftentimes that means specialization because we get increased performance at the expense of being a generalist robot. I think in the case of SubT, we want to have our cake and eat it too—we want robots that perform well and reliably, but we want them to do so not just in one environment, which is how we tend to think about robot performance, but we want them to operate well in many environments, many of which have yet to be faced.

And I think that's kind of the nuance here, that we want robot systems to be generalists for the sake of being able to handle the unknown, namely the real world, but still achieve a high level of performance and perhaps they do that to their combined use of different technologies or advances in autonomy or perception approaches or novel mechanisms or mobility, but somehow they're still able, at least in aggregate, to achieve high performance.

We know these teams eagerly await any type of clue that DARPA can provide like about the SubT environments. From the environment previews for Tunnel, Urban, and even Cave, the teams were pivoting around and thinking a little bit differently. The takeaway, however, was that they didn't go to a clean sheet design—their systems were flexible enough that they could incorporate some of those specialist trends while still maintaining the notion of a generalist framework.

Looking ahead to the SubT Final, what can you tell us about the Louisville Mega Cavern?

As always, I’ll keep you in suspense until we get you there, but I can say that from the beginning of the SubT Challenge we had always envisioned teams of robots that are able to address not only the uncertainty of what's right in front of them, but also the uncertainty of what comes next. So I think the teams will be advantaged by thinking through subdomain awareness, or domain awareness if you want to generalize it, whether that means tuning multi-purpose robots, or deploying different robots, or employing your team of robots differently. Knowing which subdomain you are in is likely to be helpful, because then you can take advantage of those unique lessons learned through all those previous experiences then capitalize on that.

As far as specifics, I think the Mega Cavern offers many of the features important to what it means to be underground, while giving DARPA a pretty blank canvas to realize our vision of the SubT Challenge.

The SubT Final will be different from the earlier circuits in that there’s just one 60-minute run, rather than two. This is going to make things a lot more stressful for teams who have experienced bad robot days—why do it this way?

The preliminary round has two 30-minute runs, and those two runs are very similar to how we have done it during the circuits, of a single run per configuration per course. Teams will have the opportunity to show that their systems can face the obstacles in the final course, and it's the sum of those scores much like we did during the circuits, to help mitigate some of the concerns that you mentioned of having one robot somehow ruin their chances at a prize.

The prize round does give DARPA as well as the community a chance to focus on the top six teams from the preliminary round, and allows us to understand how they came to be at the top of the pack while emphasizing their technological contributions. The prize round will be one and done, but all of these teams we anticipate will be putting their best robot forward and will show the world why they deserve to win the SubT Challenge.

We’ve always thought that when called upon these robots need to operate in really challenging environments, and in the context of real world operations, there is no second chance. I don't think it's actually that much of a departure from our interests and insistence on bringing reliable technologies to the field, and those teams that might have something break here and there, that's all part of the challenge, of being resilient. Many teams struggled with robots that were debilitated on the course, and they still found ways to succeed and overcome that in the field, so maybe the rules emphasize that desire for showing up and working on game day which is consistent, I think, with how we've always envisioned it. This isn’t to say that these systems have to work perfectly, they just have to work in a way such that the team is resilient enough to tackle anything that they face.

It’s not too late for teams to enter for both the Virtual Track and the Systems Track to compete in the SubT Final, right?

Yes, that's absolutely right. Qualifications are still open, we are eager to welcome new teams to join in along with our existing competitors. I think any dark horse competitors coming into the Finals may be able to bring something that we haven't seen before, and that would be really exciting. I think it'll really make for an incredibly vibrant and illuminating final event.

The final event qualification deadline for the Systems Competition is April 21, and the qualification deadline for the Virtual Competition is June 29. More details here. Continue reading

Posted in Human Robots

#437608 Video Friday: Agility Robotics Raises ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

IROS 2020 – October 25-29, 2020 – [Online]
ROS World 2020 – November 12, 2020 – [Online]
CYBATHLON 2020 – November 13-14, 2020 – [Online]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today’s videos.

Digit is now in full commercial production and we’re excited to announce a $20M funding rounding round co-led by DCVC and Playground Global!

Digits for everyone!

[ Agility Robotics ]

A flexible rover that has both ability to travel long distances and rappel down hard-to-reach areas of scientific interest has undergone a field test in the Mojave Desert in California to showcase its versatility. Composed of two Axel robots, DuAxel is designed to explore crater walls, pits, scarps, vents and other extreme terrain on the moon, Mars and beyond.

This technology demonstration developed at NASA’s Jet Propulsion Laboratory in Southern California showcases the robot’s ability to split in two and send one of its halves — a two-wheeled Axle robot — over an otherwise inaccessible slope, using a tether as support and to supply power.

The rappelling Axel can then autonomously seek out areas to study, safely overcome slopes and rocky obstacles, and then return to dock with its other half before driving to another destination. Although the rover doesn’t yet have a mission, key technologies are being developed that might, one day, help us explore the rocky planets and moons throughout the solar system.

[ JPL ]

A rectangular robot as tiny as a few human hairs can travel throughout a colon by doing back flips, Purdue University engineers have demonstrated in live animal models. Why the back flips? Because the goal is to use these robots to transport drugs in humans, whose colons and other organs have rough terrain. Side flips work, too. Why a back-flipping robot to transport drugs? Getting a drug directly to its target site could remove side effects, such as hair loss or stomach bleeding, that the drug may otherwise cause by interacting with other organs along the way.

[ Purdue ]

This video shows the latest results in the whole-body locomotion control of the humanoid robot iCub achieved by the Dynamic Interaction Control line at IIT-Istituto Italiano di Tecnologia in Genova (Italy). In particular, the iCub now keeps the balance while walking and receiving pushes from an external user. The implemented control algorithms also ensure the robot to remain compliant during locomotion and human-robot interaction, a fundamental property to lower the possibility to harm humans that share the robot surrounding environment.

This is super impressive, considering that iCub was only able to crawl and was still tethered not too long ago. Also, it seems to be blinking properly now, so it doesn’t look like it’s always sleepy.

[ IIT ]

This video shows a set of new tests we performed on Bolt. We conducted tests on 5 different scenarios, 1) walking forward/backward 2) uneven surface 3) soft surface 4) push recovery 5) slippage recovery. Thanks to our feedback control based on Model Predictive Control, the robot can perform walking in the presence of all these uncertainties. We will open-source all the codes in a near future.

[ ODRI ]

The title of this video is “Can you throw your robot into a lake?” The title of this video should be, “Can you throw your robot into a lake and drive it out again?”

[ Norlab ]

AeroVironment Successfully Completes Sunglider Solar HAPS Stratospheric Test Flight, Surpassing 60,000 Feet Altitude and Demonstrating Broadband Mobile Connectivity.

[ AeroVironment ]

We present CoVR, a novel robotic interface providing strong kinesthetic feedback (100 N) in a room-scale VR arena. It consists of a physical column mounted on a 2D Cartesian ceiling robot (XY displacements) with the capacity of (1) resisting to body-scaled users actions such as pushing or leaning; (2) acting on the users by pulling or transporting them as well as (3) carrying multiple potentially heavy objects (up to 80kg) that users can freely manipulate or make interact with each other.

[ DeepAI ]

In a new video, personnel from Swiss energy supply company Kraftwerke Oberhasli AG (KWO) explain how they were able to keep employees out of harm’s way by using Flyability’s Elios 2 to collect visual data while building a new dam.

[ Flyability ]

Enjoy our Ascento robot fail compilation! With every failure we experience, we learn more and we can improve our robot for its next iteration, which will come soon… Stay tuned for more!

FYI posting a robot fails video will pretty much guarantee you a spot in Video Friday!

[ Ascento ]

Humans are remarkably good at using chopsticks. The Guinness World Record witnessed a person using chopsticks to pick up 65 M&Ms in just a minute. We aim to collect demonstrations from humans and to teach robot to use chopsticks.

[ UW Personal Robotics Lab ]

A surprising amount of personality from these Yaskawa assembly robots.

[ Yaskawa ]

This paper presents the system design, modeling, and control of the Aerial Robotic Chain Manipulator. This new robot design offers the potential to exert strong forces and moments to the environment, carry and lift significant payloads, and simultaneously navigate through narrow corridors. The presented experimental studies include a valve rotation task, a pick-and-release task, and the verification of load oscillation suppression to demonstrate the stability and performance of the system.

[ ARL ]

Whether animals or plants, whether in the water, on land or in the air, nature provides the model for many technical innovations and inventions. This is summed up in the term bionics, which is a combination of the words ‘biology‘ and ‘electronics’. At Festo, learning from nature has a long history, as our Bionic Learning Network is based on using nature as the source for future technologies like robots, assistance systems or drive solutions.

[ Festo ]

Dogs! Selfies! Thousands of LEGO bricks! This video has it all.

[ LEGO ]

An IROS workshop talk on “Cassie and Mini Cheetah Autonomy” by Maani Ghaffari and Jessy Grizzle from the University of Michigan.

[ Michigan Robotics ]

David Schaefer’s Cozmo robots are back with this mind-blowing dance-off!

What you just saw represents hundreds of hours of work, David tells us: “I wrote over 10,000 lines of code to create the dance performance as I had to translate the beats per minute of the song into motor rotations in order to get the right precision needed to make the moves look sharp. The most challenging move was the SpongeBob SquareDance as any misstep would send the Cozmos crashing into each other. LOL! Fortunately for me, Cozmo robots are pretty resilient.”

[ Life with Cozmo ]

Thanks David!

This week’s GRASP on Robotics seminar is by Sangbae Kim from MIT, on “Robots with Physical Intelligence.”

While industrial robots are effective in repetitive, precise kinematic tasks in factories, the design and control of these robots are not suited for physically interactive performance that humans do easily. These tasks require ‘physical intelligence’ through complex dynamic interactions with environments whereas conventional robots are designed primarily for position control. In order to develop a robot with ‘physical intelligence’, we first need a new type of machines that allow dynamic interactions. This talk will discuss how the new design paradigm allows dynamic interactive tasks. As an embodiment of such a robot design paradigm, the latest version of the MIT Cheetah robots and force-feedback teleoperation arms will be presented.

[ GRASP ]

This week’s CMU Ri Seminar is by Kevin Lynch from Northwestern, on “Robotics and Biosystems.”

Research at the Center for Robotics and Biosystems at Northwestern University encompasses bio-inspiration, neuromechanics, human-machine systems, and swarm robotics, among other topics. In this talk I will give an overview of some of our recent work on in-hand manipulation, robot locomotion on yielding ground, and human-robot systems.

[ CMU RI ] Continue reading

Posted in Human Robots

#437373 Microsoft’s New Deepfake Detector Puts ...

The upcoming US presidential election seems set to be something of a mess—to put it lightly. Covid-19 will likely deter millions from voting in person, and mail-in voting isn’t shaping up to be much more promising. This all comes at a time when political tensions are running higher than they have in decades, issues that shouldn’t be political (like mask-wearing) have become highly politicized, and Americans are dramatically divided along party lines.

So the last thing we need right now is yet another wrench in the spokes of democracy, in the form of disinformation; we all saw how that played out in 2016, and it wasn’t pretty. For the record, disinformation purposely misleads people, while misinformation is simply inaccurate, but without malicious intent. While there’s not a ton tech can do to make people feel safe at crowded polling stations or up the Postal Service’s budget, tech can help with disinformation, and Microsoft is trying to do so.

On Tuesday the company released two new tools designed to combat disinformation, described in a blog post by VP of Customer Security and Trust Tom Burt and Chief Scientific Officer Eric Horvitz.

The first is Microsoft Video Authenticator, which is made to detect deepfakes. In case you’re not familiar with this wicked byproduct of AI progress, “deepfakes” refers to audio or visual files made using artificial intelligence that can manipulate peoples’ voices or likenesses to make it look like they said things they didn’t. Editing a video to string together words and form a sentence someone didn’t say doesn’t count as a deepfake; though there’s manipulation involved, you don’t need a neural network and you’re not generating any original content or footage.

The Authenticator analyzes videos or images and tells users the percentage chance that they’ve been artificially manipulated. For videos, the tool can even analyze individual frames in real time.

Deepfake videos are made by feeding hundreds of hours of video of someone into a neural network, “teaching” the network the minutiae of the person’s voice, pronunciation, mannerisms, gestures, etc. It’s like when you do an imitation of your annoying coworker from accounting, complete with mimicking the way he makes every sentence sound like a question and his eyes widen when he talks about complex spreadsheets. You’ve spent hours—no, months—in his presence and have his personality quirks down pat. An AI algorithm that produces deepfakes needs to learn those same quirks, and more, about whoever the creator’s target is.

Given enough real information and examples, the algorithm can then generate its own fake footage, with deepfake creators using computer graphics and manually tweaking the output to make it as realistic as possible.

The scariest part? To make a deepfake, you don’t need a fancy computer or even a ton of knowledge about software. There are open-source programs people can access for free online, and as far as finding video footage of famous people—well, we’ve got YouTube to thank for how easy that is.

Microsoft’s Video Authenticator can detect the blending boundary of a deepfake and subtle fading or greyscale elements that the human eye may not be able to see.

In the blog post, Burt and Horvitz point out that as time goes by, deepfakes are only going to get better and become harder to detect; after all, they’re generated by neural networks that are continuously learning from and improving themselves.

Microsoft’s counter-tactic is to come in from the opposite angle, that is, being able to confirm beyond doubt that a video, image, or piece of news is real (I mean, can McDonald’s fries cure baldness? Did a seal slap a kayaker in the face with an octopus? Never has it been so imperative that the world know the truth).

A tool built into Microsoft Azure, the company’s cloud computing service, lets content producers add digital hashes and certificates to their content, and a reader (which can be used as a browser extension) checks the certificates and matches the hashes to indicate the content is authentic.

Finally, Microsoft also launched an interactive “Spot the Deepfake” quiz it developed in collaboration with the University of Washington’s Center for an Informed Public, deepfake detection company Sensity, and USA Today. The quiz is intended to help people “learn about synthetic media, develop critical media literacy skills, and gain awareness of the impact of synthetic media on democracy.”

The impact Microsoft’s new tools will have remains to be seen—but hey, we’re glad they’re trying. And they’re not alone; Facebook, Twitter, and YouTube have all taken steps to ban and remove deepfakes from their sites. The AI Foundation’s Reality Defender uses synthetic media detection algorithms to identify fake content. There’s even a coalition of big tech companies teaming up to try to fight election interference.

One thing is for sure: between a global pandemic, widespread protests and riots, mass unemployment, a hobbled economy, and the disinformation that’s remained rife through it all, we’re going to need all the help we can get to make it through not just the election, but the rest of the conga-line-of-catastrophes year that is 2020.

Image Credit: Darius Bashar on Unsplash Continue reading

Posted in Human Robots

#437209 A Renaissance of Genomics and Drugs Is ...

The causes of aging are extremely complex and unclear. But with longevity clinical trials increasing, more answers—and questions—are emerging than ever before.

With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to turn those answers into practical ways to extend our healthspan.

In this article, I’ll explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

Genome Sequencing and Editing
Your genome is the software that runs your body. A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity for disease, your lifespan, and so on.

Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean. Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $1,500 in 2015.

Today, the cost of genome sequencing has dropped below $600, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.

This represents one of the most powerful and transformative technology revolutions in healthcare. When we understand your genome, we’ll be able to understand how to optimize “you.”

We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later article).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).

CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally occurring biological system discovered in 1987 called CRISPR/Cas9.

Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.

Here’s how it works. The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays. The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions. If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.

Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome. A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.

2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers have used CRISPR to genetically engineer cocaine resistance into mice, reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs, and reduce genetic deafness in mice.

Already this year, CRISPR-edited immune cells have been shown to successfully kill cancer cells in human patients. Researchers have discovered ways to activate CRISPR with light and use the gene-editing technology to better understand Alzheimer’s disease progression.

With great power comes great responsibility, and the opportunity for moral and ethical dilemmas. In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera. Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.

To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells. Because Jiankui forged ethical review documents and misled doctors in the process, he was sentenced to three years in prison and fined $429,000 last December.

Coupled with significant ethical conversations necessary for progress, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.

Senolytics, Nutraceuticals, and Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.

What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely. These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse. Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification to localized inflammatory conditions such as osteoarthritis to diminished lung function.

Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.

Prominent companies in the field include the following:

Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology, and pulmonary disease.

Oisin Biotechnologies is pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.

SIWA Therapeutics is working on an immunotherapy approach to the problem of senescent cells.

In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.

(1) Rapamycin

Originally extracted from bacteria found on Easter Island, rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division. Currently, rapamycin derivatives are widely used for immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.

PureTech Health subsidiary resTORbio (which went public in 2018) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.

Results of the drug’s recent clinical trial include decreased incidence of infection, improved influenza vaccination response, and a 30.6 percent decrease in respiratory tract infection.

Impressive, to say the least.

(2) Metformin

Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients. Researchers have found that metformin also reduces oxidative stress and inflammation, which otherwise increase as we age. There is strong evidence that metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.

Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of metformin’s protective effect against cancer.

(3) Nutraceuticals and NAD+

Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.

NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.

The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s first clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.

Conclusion
These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.

The next article in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.

We are edging closer toward a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?

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This article originally appeared on diamandis.com. Read the original article here.

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Posted in Human Robots

#436911 Scientists Linked Artificial and ...

Scientists have linked up two silicon-based artificial neurons with a biological one across multiple countries into a fully-functional network. Using standard internet protocols, they established a chain of communication whereby an artificial neuron controls a living, biological one, and passes on the info to another artificial one.

Whoa.

We’ve talked plenty about brain-computer interfaces and novel computer chips that resemble the brain. We’ve covered how those “neuromorphic” chips could link up into tremendously powerful computing entities, using engineered communication nodes called artificial synapses.

As Moore’s law is dying, we even said that neuromorphic computing is one path towards the future of extremely powerful, low energy consumption artificial neural network-based computing—in hardware—that could in theory better link up with the brain. Because the chips “speak” the brain’s language, in theory they could become neuroprosthesis hubs far more advanced and “natural” than anything currently possible.

This month, an international team put all of those ingredients together, turning theory into reality.

The three labs, scattered across Padova, Italy, Zurich, Switzerland, and Southampton, England, collaborated to create a fully self-controlled, hybrid artificial-biological neural network that communicated using biological principles, but over the internet.

The three-neuron network, linked through artificial synapses that emulate the real thing, was able to reproduce a classic neuroscience experiment that’s considered the basis of learning and memory in the brain. In other words, artificial neuron and synapse “chips” have progressed to the point where they can actually use a biological neuron intermediary to form a circuit that, at least partially, behaves like the real thing.

That’s not to say cyborg brains are coming soon. The simulation only recreated a small network that supports excitatory transmission in the hippocampus—a critical region that supports memory—and most brain functions require enormous cross-talk between numerous neurons and circuits. Nevertheless, the study is a jaw-dropping demonstration of how far we’ve come in recreating biological neurons and synapses in artificial hardware.

And perhaps one day, the currently “experimental” neuromorphic hardware will be integrated into broken biological neural circuits as bridges to restore movement, memory, personality, and even a sense of self.

The Artificial Brain Boom
One important thing: this study relies heavily on a decade of research into neuromorphic computing, or the implementation of brain functions inside computer chips.

The best-known example is perhaps IBM’s TrueNorth, which leveraged the brain’s computational principles to build a completely different computer than what we have today. Today’s computers run on a von Neumann architecture, in which memory and processing modules are physically separate. In contrast, the brain’s computing and memory are simultaneously achieved at synapses, small “hubs” on individual neurons that talk to adjacent ones.

Because memory and processing occur on the same site, biological neurons don’t have to shuttle data back and forth between processing and storage compartments, massively reducing processing time and energy use. What’s more, a neuron’s history will also influence how it behaves in the future, increasing flexibility and adaptability compared to computers. With the rise of deep learning, which loosely mimics neural processing as the prima donna of AI, the need to reduce power while boosting speed and flexible learning is becoming ever more tantamount in the AI community.

Neuromorphic computing was partially born out of this need. Most chips utilize special ingredients that change their resistance (or other physical characteristics) to mimic how a neuron might adapt to stimulation. Some chips emulate a whole neuron, that is, how it responds to a history of stimulation—does it get easier or harder to fire? Others imitate synapses themselves, that is, how easily they will pass on the information to another neuron.

Although single neuromorphic chips have proven to be far more efficient and powerful than current computer chips running machine learning algorithms in toy problems, so far few people have tried putting the artificial components together with biological ones in the ultimate test.

That’s what this study did.

A Hybrid Network
Still with me? Let’s talk network.

It’s gonna sound complicated, but remember: learning is the formation of neural networks, and neurons that fire together wire together. To rephrase: when learning, neurons will spontaneously organize into networks so that future instances will re-trigger the entire network. To “wire” together, downstream neurons will become more responsive to their upstream neural partners, so that even a whisper will cause them to activate. In contrast, some types of stimulation will cause the downstream neuron to “chill out” so that only an upstream “shout” will trigger downstream activation.

Both these properties—easier or harder to activate downstream neurons—are essentially how the brain forms connections. The “amping up,” in neuroscience jargon, is long-term potentiation (LTP), whereas the down-tuning is LTD (long-term depression). These two phenomena were first discovered in the rodent hippocampus more than half a century ago, and ever since have been considered as the biological basis of how the brain learns and remembers, and implicated in neurological problems such as addition (seriously, you can’t pass Neuro 101 without learning about LTP and LTD!).

So it’s perhaps especially salient that one of the first artificial-brain hybrid networks recapitulated this classic result.

To visualize: the three-neuron network began in Switzerland, with an artificial neuron with the badass name of “silicon spiking neuron.” That neuron is linked to an artificial synapse, a “memristor” located in the UK, which is then linked to a biological rat neuron cultured in Italy. The rat neuron has a “smart” microelectrode, controlled by the artificial synapse, to stimulate it. This is the artificial-to-biological pathway.

Meanwhile, the rat neuron in Italy also has electrodes that listen in on its electrical signaling. This signaling is passed back to another artificial synapse in the UK, which is then used to control a second artificial neuron back in Switzerland. This is the biological-to-artificial pathway back. As a testimony in how far we’ve come in digitizing neural signaling, all of the biological neural responses are digitized and sent over the internet to control its far-out artificial partner.

Here’s the crux: to demonstrate a functional neural network, just having the biological neuron passively “pass on” electrical stimulation isn’t enough. It has to show the capacity to learn, that is, to be able to mimic the amping up and down-tuning that are LTP and LTD, respectively.

You’ve probably guessed the results: certain stimulation patterns to the first artificial neuron in Switzerland changed how the artificial synapse in the UK operated. This, in turn, changed the stimulation to the biological neuron, so that it either amped up or toned down depending on the input.

Similarly, the response of the biological neuron altered the second artificial synapse, which then controlled the output of the second artificial neuron. Altogether, the biological and artificial components seamlessly linked up, over thousands of miles, into a functional neural circuit.

Cyborg Mind-Meld
So…I’m still picking my jaw up off the floor.

It’s utterly insane seeing a classic neuroscience learning experiment repeated with an integrated network with artificial components. That said, a three-neuron network is far from the thousands of synapses (if not more) needed to truly re-establish a broken neural circuit in the hippocampus, which DARPA has been aiming to do. And LTP/LTD has come under fire recently as the de facto brain mechanism for learning, though so far they remain cemented as neuroscience dogma.

However, this is one of the few studies where you see fields coming together. As Richard Feynman famously said, “What I cannot recreate, I cannot understand.” Even though neuromorphic chips were built on a high-level rather than molecular-level understanding of how neurons work, the study shows that artificial versions can still synapse with their biological counterparts. We’re not just on the right path towards understanding the brain, we’re recreating it, in hardware—if just a little.

While the study doesn’t have immediate use cases, practically it does boost both the neuromorphic computing and neuroprosthetic fields.

“We are very excited with this new development,” said study author Dr. Themis Prodromakis at the University of Southampton. “On one side it sets the basis for a novel scenario that was never encountered during natural evolution, where biological and artificial neurons are linked together and communicate across global networks; laying the foundations for the Internet of Neuro-electronics. On the other hand, it brings new prospects to neuroprosthetic technologies, paving the way towards research into replacing dysfunctional parts of the brain with AI chips.”

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Posted in Human Robots