Tag Archives: personality

#435742 This ‘Useless’ Social Robot ...

Posted on September 19, 2019 by Android

The recent high profile failures of some home social robots (and the companies behind them) have made it even more challenging than it was before to develop robots in that space. And it was challenging enough to begin with—making a robot that can autonomous interact with random humans in their homes over a long period of time for a price that people can afford is extraordinarily difficult. However, the massive amount of initial interest in robots like Jibo, Kuri, Vector, and Buddy prove that people do want these things, or at least think they do, and while that’s the case, there’s incentive for other companies to give social home robots a try.

One of those companies is Zoetic, founded in 2107 by Mita Yun and Jitu Das, both ex-Googlers. Their robot, Kiki, is more or less exactly what you’d expect from a social home robot: It’s cute, white, roundish, has big eyes, promises that it will be your “robot sidekick,” and is not cheap: It’s on Kicksterter for $800. Kiki is among what appears to be a sort of tentative second wave of social home robots, where designers have (presumably) had a chance to take everything that they learned from the social home robot pioneers and use it to make things better this time around.

Kiki’s Kickstarter video is, again, more or less exactly what you’d expect from a social home robot crowdfunding campaign:

We won’t get into all of the details on Kiki in this article (the Kickstarter page has tons of information), but a few distinguishing features:

Each Kiki will develop its own personality over time through its daily interactions with its owner, other people, and other Kikis.
Interacting with Kiki is more abstract than with most robots—it can understand some specific words and phrases, and will occasionally use a few specific words or two, but otherwise it’s mostly listening to your tone of voice and responding with sounds rather than speech.
Kiki doesn’t move on its own, but it can operate for up to two hours away from its charging dock.
Depending on how your treat Kiki, it can get depressed or neurotic. It also needs to be fed, which you can do by drawing different kinds of food in the app.
Everything Kiki does runs on-board the robot. It has Wi-Fi connectivity for updates, but doesn’t rely on the cloud for anything in real-time, meaning that your data stays on the robot and that the robot will continue to function even if its remote service shuts down.

It’s hard to say whether features like these are unique enough to help Kiki be successful where other social home robots haven’t been, so we spoke with Zoetic co-founder Mita Yun and asked her why she believes that Kiki is going to be the social home robot that makes it.

IEEE Spectrum: What’s your background?

Mita Yun: I was an only child growing up, and so I always wanted something like Doraemon or Totoro. Something that when you come home it’s there to greet you, not just because it’s programmed to do that but because it’s actually actively happy to see you, and only you. I was so interested in this that I went to study robotics at CMU and then after I graduated I joined Google and worked there for five years. I tended to go for the more risky and more fun projects, but they always got cancelled—the first project I joined was called Android at Home, and then I joined Google Glass, and then I joined a team called Robots for Kids. That project was building educational robots, and then I just realized that when we’re adding technology to something, to a product, we’re actually taking the life away somehow, and the kids were more connected with stuffed animals compared to the educational robots we were building. That project was also cancelled, and in 2017, I left with a coworker of mine (Jitu Das) to bring this dream into reality. And now we’re building Kiki.

“Jibo was Alexa plus cuteness equals $800, and I feel like that equation doesn’t work for most people, and that eventually killed the company. So, for Kiki, we are actually building something very different. We’re building something that’s completely useless”
—Mita Yun, Zoetic

You started working on Kiki in 2017, when things were already getting challenging for Jibo—why did you decide to start developing a social home robot at that point?

I thought Jibo was great. It had a special magical way of moving, and it was such a new idea that you could have this robot with embodiment and it can actually be your assistant. The problem with Jibo, in my opinion, was that it took too long to fulfill the orders. It took them three to four years to actually manufacture, because it was a very complex piece of hardware, and then during that period of time Alexa and Google Home came out, and they started selling these voice systems for $30 and then you have Jibo for $800. Jibo was Alexa plus cuteness equals $800, and I feel like that equation doesn’t work for most people, and that eventually killed the company. So, for Kiki, we are actually building something very different. We’re building something that’s completely useless.

Can you elaborate on “completely useless?”

I feel like people are initially connected with robots because they remind them of a character. And it’s the closest we can get to a character other than an organic character like an animal. So we’re connected to a character like when we have a robot in a mall that’s roaming around, even if it looks really ugly, like if it doesn’t have eyes, people still take selfies with it. Why? Because they think it’s a character. And humans are just hardwired to love characters and love stories. With Kiki, we just wanted to build a character that’s alive, we don’t want to have a character do anything super useful.

I understand why other robotics companies are adding Alexa integration to their robots, and I think that’s great. But the dream I had, and the understanding I have about robotics technology, is that for a consumer robot especially, it is very very difficult for the robot to justify its price through usefulness. And then there’s also research showing that the more useless something is, the easier it is to have an emotional connection, so that’s why we want to keep Kiki very useless.

What kind of character are you creating with Kiki?

The whole design principle around Kiki is we want to make it a very vulnerable character. In terms of its status at home, it’s not going to be higher or equal status as the owner, but slightly lower status than the human, and it’s vulnerable and needs you to take care of it in order to grow up into a good personality robot.

We don’t let Kiki speak full English sentences, because whenever it does that, people are going to think it’s at least as intelligent as a baby, which is impossible for robots at this point. And we also don’t let it move around, because when you have it move around, people are going to think “I’m going to call Kiki’s name, and then Kiki is will come to me.” But that is actually very difficult to build. And then also we don’t have any voice integration so it doesn’t tell you about the stock market price and so on.

Photo: Zoetic

Kiki is designed to be “vulnerable,” and it needs you to take care of it so it can “grow up into a good personality robot,” according to its creators.

That sounds similar to what Mayfield did with Kuri, emphasizing an emotional connection rather than specific functionality.

It is very similar, but one of the key differences from Kuri, I think, is that Kuri started with a Kobuki base, and then it’s wrapped into a cute shell, and they added sounds. So Kuri started with utility in mind—navigation is an important part of Kuri, so they started with that challenge. For Kiki, we started with the eyes. The entire thing started with the character itself.

How will you be able to convince your customers to spend $800 on a robot that you’ve described as “useless” in some ways?

Because it’s useless, it’s actually easier to convince people, because it provides you with an emotional connection. I think Kiki is not a utility-driven product, so the adoption cycle is different. For a functional product, it’s very easy to pick up, because you can justify it by saying “I’m going to pay this much and then my life can become this much more efficient.” But it’s also very easy to be replaced and forgotten. For an emotional-driven product, it’s slower to pick up, but once people actually pick it up, they’re going to be hooked—they get be connected with it, and they’re willing to invest more into taking care of the robot so it will grow up to be smarter.

Maintaining value over time has been another challenge for social home robots. How will you make sure that people don’t get bored with Kiki after a few weeks?

Of course Kiki has limits in what it can do. We can combine the eyes, the facial expression, the motors, and lights and sounds, but is it going to be constantly entertaining? So we think of this as, imagine if a human is actually puppeteering Kiki—can Kiki stay interesting if a human is puppeteering it and interacting with the owner? So I think what makes a robot interesting is not just in the physical expressions, but the part in between that and the robot conveying its intentions and emotions.

For example, if you come into the room and then Kiki decides it will turn the other direction, ignore you, and then you feel like, huh, why did the robot do that to me? Did I do something wrong? And then maybe you will come up to it and you will try to figure out why it did that. So, even though Kiki can only express in four different dimensions, it can still make things very interesting, and then when its strategies change, it makes it feel like a new experience.

There’s also an explore and exploit process going on. Kiki wants to make you smile, and it will try different things. It could try to chase its tail, and if you smile, Kiki learns that this works and will exploit it. But maybe after doing it three times, you no longer find it funny, because you’re bored of it, and then Kiki will observe your reactions and be motivated to explore a new strategy.

Photo: Zoetic

Kiki’s creators are hoping that, with an emotionally engaging robot, it will be easier for people to get attached to it and willing to spend time taking care of it.

A particular risk with crowdfunding a robot like this is setting expectations unreasonably high. The emphasis on personality and emotional engagement with Kiki seems like it may be very difficult for the robot to live up to in practice.

I think we invested more than most robotics companies into really building out Kiki’s personality, because that is the single most important thing to us. For Jibo a lot of the focus was in the assistant, and for Kuri, it’s more in the movement. For Kiki, it’s very much in the personality.

I feel like when most people talk about personality, they’re mainly talking about expression. With Kiki, it’s not just in the expression itself, not just in the voice or the eyes or the output layer, it’s in the layer in between—when Kiki receives input, how will it make decisions about what to do? We actually don’t think the personality of Kiki is categorizable, which is why I feel like Kiki has a deeper implementation of how personalities should work. And you’re right, Kiki doesn’t really understand why you’re feeling a certain way, it just reads your facial expressions. It’s maybe not your best friend, but maybe closer to your little guinea pig robot.

Photo: Zoetic

The team behind Kiki paid particular attention to its eyes, and designed the robot to always face the person that it is interacting with.

Is that where you’d put Kiki on the scale of human to pet?

Kiki is definitely not human, we want to keep it very far away from human. And it’s also not a dog or cat. When we were designing Kiki, we took inspiration from mammals because humans are deeply connected to mammals since we’re mammals ourselves. And specifically we’re connected to predator animals. With prey animals, their eyes are usually on the sides of their heads, because they need to see different angles. A predator animal needs to hunt, they need to focus. Cats and dogs are predator animals. So with Kiki, that’s why we made sure the eyes are on one side of the face and the head can actuate independently from the body and the body can turn so it’s always facing the person that it’s paying attention to.

I feel like Kiki is probably does more than a plant. It does more than a fish, because a fish doesn’t look you in the eyes. It’s not as smart as a cat or a dog, so I would just put it in this guinea pig kind of category.

What have you found so far when running user studies with Kiki?

When we were first designing Kiki we went through a whole series of prototypes. One of the earlier prototypes of Kiki looked like a CRT, like a very old monitor, and when we were testing that with people they didn’t even want to touch it. Kiki’s design inspiration actually came from an airplane, with a very angular, futuristic look, but based on user feedback we made it more round and more friendly to the touch. The lights were another feature request from the users, which adds another layer of expressivity to Kiki, and they wanted to see multiple Kikis working together with different personalities. Users also wanted different looks for Kiki, to make it look like a deer or a unicorn, for example, and we actually did take that into consideration because it doesn’t look like any particular mammal. In the future, you’ll be able to have different ears to make it look like completely different animals.

There has been a lot of user feedback that we didn’t implement—I believe we should observe the users reactions and feedback but not listen to their advice. The users shouldn’t be our product designers, because if you test Kiki with 10 users, eight of them will tell you they want Alexa in it. But we’re never going to add Alexa integration to Kiki because that’s not what it’s meant to do.

While it’s far too early to tell whether Kiki will be a long-term success, the Kickstarter campaign is currently over 95 percent funded with 8 days to go, and 34 robots are still available for a May 2020 delivery.

[ Kickstarter ] Continue reading →

Posted in Human Robots

#435683 How High Fives Help Us Get in Touch With ...

Posted on September 16, 2019 by Android

The human sense of touch is so naturally ingrained in our everyday lives that we often don’t notice its presence. Even so, touch is a crucial sensing ability that helps people to understand the world and connect with others. As the market for robots grows, and as robots become more ingrained into our environments, people will expect robots to participate in a wide variety of social touch interactions. At Oregon State University’s Collaborative Robotics and Intelligent Systems (CoRIS) Institute, I research how to equip everyday robots with better social-physical interaction skills—from playful high-fives to challenging physical therapy routines.

Some commercial robots already possess certain physical interaction skills. For example, the videoconferencing feature of mobile telepresence robots can keep far-away family members connected with one another. These robots can also roam distant spaces and bump into people, chairs, and other remote objects. And my Roomba occasionally tickles my toes before turning to vacuum a different area of the room. As a human being, I naturally interpret this (and other Roomba behaviors) as social, even if they were not intended as such. At the same time, for both of these systems, social perceptions of the robots’ physical interaction behaviors are not well understood, and these social touch-like interactions cannot be controlled in nuanced ways.

Before joining CoRIS early this year, I was a postdoc at the University of Southern California’s Interaction Lab, and prior to that, I completed my doctoral work at the GRASP Laboratory’s Haptics Group at the University of Pennsylvania. My dissertation focused on improving the general understanding of how robot control and planning strategies influence perceptions of social touch interactions. As part of that research, I conducted a study of human-robot hand-to-hand contact, focusing on an interaction somewhere between a high five and a hand-clapping game. I decided to study this particular interaction because people often high five, and they will likely expect robots in everyday spaces to high five as well!

I conducted a study of human-robot hand-to-hand contact, focusing on an interaction somewhere between a high five and a hand-clapping game. I decided to study this particular interaction because people often high five, and they will likely expect robots to high five as well!

The implications of motion and planning on the social touch experience in these interactions is also crucial—think about a disappointingly wimpy (or triumphantly amazing) high five that you’ve experienced in the past. This great or terrible high-fiving experience could be fleeting, but it could also influence who you interact with, who you’re friends with, and even how you perceive the character or personalities of those around you. This type of perception, judgement, and response could extend to personal robots, too!

An investigation like this requires a mixture of more traditional robotics research (e.g., understanding how to move and control a robot arm, developing models of the desired robot motion) along with techniques from design and psychology (e.g., performing interviews with research participants, using best practices from experimental methods in perception). Enabling robots with social touch abilities also comes with many challenges, and even skilled humans can have trouble anticipating what another person is about to do. Think about trying to make satisfying hand contact during a high five—you might know the classic adage “watch the elbow,” but if you’re like me, even this may not always work.

I conducted a research study involving eight different types of human-robot hand contact, with different combinations of the following: interactions with a facially reactive or non-reactive robot, a physically reactive or non-reactive planning strategy, and a lower or higher robot arm stiffness. My robotic system could become facially reactive by changing its facial expression in response to hand contact, or physically reactive by updating its plan of where to move next after sensing hand contact. The stiffness of the robot could be adjusted by changing a variable that controlled how quickly the robot’s motors tried to pull its arm to the desired position. I knew from previous research that fine differences in touch interactions can have a big impact on perceived robot character. For example, if a robot grips an object too tightly or for too long while handing an object to a person, it might be perceived as greedy, possessive, or perhaps even Sméagol-like. A robot that lets go too soon might appear careless or sloppy.

In the example cases of robot grip, it’s clear that understanding people’s perceptions of robot characteristics and personality can help roboticists choose the right robot design based on the proposed operating environment of the robot. I likewise wanted to learn how the facial expressions, physical reactions, and stiffness of a hand-clapping robot would influence human perceptions of robot pleasantness, energeticness, dominance, and safety. Understanding this relationship can help roboticists to equip robots with personalities appropriate for the task at hand. For example, a robot assisting people in a grocery store may need to be designed with a high level of pleasantness and only moderate energy, while a maximally effective robot for comedy roast battles may need high degrees of energy and dominance above all else.

After many a late night at the GRASP Lab clapping hands with a big red robot, I was ready to conduct the study. Twenty participants visited the lab to clap hands with our Baxter Research Robot and help me begin to understand how characteristics of this humanoid robot’s social touch influenced its pleasantness, energeticness, dominance, and apparent safety. Baxter interacted with participants using a custom 3D-printed hand that was inlaid with silicone inserts.

The study showed that a facially reactive robot seemed more pleasant and energetic. A physically reactive robot seemed less pleasant, energetic, and dominant for this particular study design and interaction. I thought contact with a stiffer robot would seem harder (and therefore more dominant and less safe), but counter to my expectations, a stiffer-armed robot seemed safer and less dominant to participants. This may be because the stiffer robot was more precise in following its pre-programmed trajectory, therefore seeming more predictable and less free-spirited.

Safety ratings of the robot were generally high, and several participants commented positively on the robot’s facial expressions. Some participants attributed inventive (and non-existent) intelligences to the robot—I used neither computer vision nor the Baxter robot’s cameras in this study, but more than one participant complimented me on how well the robot tracked their hand position. While interacting with the robot, participants displayed happy facial expressions more than any other analyzed type of expression.

Photo: Naomi Fitter

Participants were asked to clap hands with Baxter and describe how they perceived the robot in terms of its pleasantness, energeticness, dominance, and apparent safety.

Circling back to the idea of how people might interpret even rudimentary and practical robot behaviors as social, these results show that this type of social perception isn’t just true for my lovable (but sometimes dopey) Roomba, but also for collaborative industrial robots, and generally, any robot capable of physical human-robot interaction. In designing the motion of Baxter, the adjustment of a single number in the equation that controls joint stiffness can flip the robot from seeming safe and docile to brash and commanding. These implications are sometimes predictable, but often unexpected.

The results of this particular study give us a partial guide to manipulating the emotional experience of robot users by adjusting aspects of robot control and planning, but future work is needed to fully understand the design space of social touch. Will materials play a major role? How about personalized machine learning? Do results generalize over all robot arms, or even a specialized subset like collaborative industrial robot arms? I’m planning to continue answering these questions, and when I finally solve human-robot social touch, I’ll high five all my robots to celebrate.

Naomi Fitter is an assistant professor in the Collaborative Robotics and Intelligent Systems (CoRIS) Institute at Oregon State University, where her Social Haptics, Assistive Robotics, and Embodiment (SHARE) research group aims to equip robots with the ability to engage and empower people in interactions from playful high-fives to challenging physical therapy routines. She completed her doctoral work in the GRASP Laboratory’s Haptics Group and was a postdoctoral scholar in the University of Southern California’s Interaction Lab from 2017 to 2018. Naomi’s not-so-secret pastime is performing stand-up and improv comedy. Continue reading →

Posted in Human Robots

#435646 Video Friday: Kiki Is a New Social Robot ...

Posted on September 14, 2019 by Android

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

DARPA SubT Tunnel Circuit – August 15-22, 2019 – Pittsburgh, Pa., USA
IEEE Africon 2019 – September 25-27, 2019 – Accra, Ghana
ISRR 2019 – October 6-10, 2019 – Hanoi, Vietnam
Ro-Man 2019 – October 14-18, 2019 – New Delhi, India
Humanoids 2019 – October 15-17, 2019 – Toronto, Canada
ARSO 2019 – October 31-1, 2019 – Beijing, China
ROSCon 2019 – October 31-1, 2019 – Macau
Let us know if you have suggestions for next week, and enjoy today’s videos.

The DARPA Subterranean Challenge tunnel circuit takes place in just a few weeks, and we’ll be there!

[ DARPA SubT ]

Time lapse video of robotic arm on NASA’s Mars 2020 rover handily maneuvers 88-pounds (40 kilograms) worth of sensor-laden turret as it moves from a deployed to stowed configuration.

If you haven’t read our interview with Matt Robinson, now would be a great time, since he’s one of the folks at JPL who designed this arm.

[ Mars 2020 ]

Kiki is a small, white, stationary social robot with an evolving personality who promises to be your friend and costs $800 and is currently on Kickstarter.

The Kickstarter page is filled with the same type of overpromising that we’ve seen with other (now very dead) social robots: Kiki is “conscious,” “understands your feelings,” and “loves you back.” Oof. That said, we’re happy to see more startups trying to succeed in this space, which is certainly one of the toughest in consumer electronics, and hopefully they’ve been learning from the recent string of failures. And we have to say Kiki is a cute robot. Its overall design, especially the body mechanics and expressive face, look neat. And kudos to the team—the company was founded by two ex-Googlers, Mita Yun and Jitu Das—for including the “unedited prototype videos,” which help counterbalance the hype.

Another thing that Kiki has going for it is that everything runs on the robot itself. This simplifies privacy and means that the robot won’t partially die on you if the company behind it goes under, but also limits how clever the robot will be able to be. The Kickstarter campaign is already over a third funded, so…We’ll see.

[ Kickstarter ]

When your UAV isn’t enough UAV, so you put a UAV on your UAV.

[ CanberraUAV ]

ABB’s YuMi is testing ATMs because a human trying to do this task would go broke almost immediately.

[ ABB ]

DJI has a fancy new FPV system that features easy setup, digital HD streaming at up to 120 FPS, and <30ms latency.

If it looks expensive, that’s because it costs $930 with the remote included.

[ DJI ]

Honeybee Robotics has recently developed a regolith excavation and rock cleaning system for NASA JPL’s PUFFER rovers. This system, called POCCET (PUFFER-Oriented Compact Cleaning and Excavation Tool), uses compressed gas to perform all excavation and cleaning tasks. Weighing less than 300 grams with potential for further mass reduction, POCCET can be used not just on the Moon, but on other Solar System bodies such as asteroids, comets, and even Mars.

[ Honeybee Robotics ]

DJI’s 2019 RoboMaster tournament, which takes place this month in Shenzen, looks like it’ll be fun to watch, with a plenty of action and rules that are easy to understand.

[ RoboMaster ]

Robots and baked goods are an automatic Video Friday inclusion.

Wow I want a cupcake right now.

[ Soft Robotics ]

The ICRA 2019 Best Paper Award went to Michelle A. Lee at Stanford, for “Making Sense of Vision and Touch: Self-Supervised Learning of Multimodal Representations for Contact-Rich Tasks.”

The ICRA video is here, and you can find the paper at the link below.

[ Paper ] via [ RoboHub ]

Cobalt Robotics put out a bunch of marketing-y videos this week, but this one reasonably interesting, even if you’re familiar with what they’re doing over there.

[ Cobalt Robotics ]

RightHand Robotics launched RightPick2 with a gala event which looked like fun as long as you were really, really in to robots.

[ RightHand Robotics ]

Thanks Jeff!

This video presents a framework for whole-body control applied to the assistive robotic system EDAN. We show how the proposed method can be used for a task like open, pass through and close a door. Also, we show the efficiency of the whole-body coordination with controlling the end-effector with respect to a fixed reference. Additionally, showing how easy the system can be manually manoeuvred by direct interaction with the end-effector, without the need for an extra input device.

[ DLR ]

You’ll probably need to turn on auto-translated subtitles for most of this, but it’s worth it for the adorable little single-seat robotic car designed to help people get around airports.

[ ZMP ]

In this week’s episode of Robots in Depth, Per speaks with Gonzalo Rey from Moog about their fancy 3D printed integrated hydraulic actuators.

Gonzalo talks about how Moog got started with hydraulic control,taking part in the space program and early robotics development. He shares how Moog’s technology is used in fly-by-wire systems in aircraft and in flow control in deep space probes. They have even reached Mars.

[ Robots in Depth ] Continue reading →

Posted in Human Robots

#435601 New Double 3 Robot Makes Telepresence ...

Posted on September 12, 2019 by Android

Today, Double Robotics is announcing Double 3, the latest major upgrade to its line of consumer(ish) telepresence robots. We had a (mostly) fantastic time testing out Double 2 back in 2016. One of the things that we found out back then was that it takes a lot of practice to remotely drive the robot around. Double 3 solves this problem by leveraging the substantial advances in 3D sensing and computing that have taken place over the past few years, giving their new robot a level of intelligence that promises to make telepresence more accessible for everyone.

Double 2’s iPad has been replaced by “a fully integrated solution”—which is a fancy way of saying a dedicated 9.7-inch touchscreen and a whole bunch of other stuff. That other stuff includes an NVIDIA Jetson TX2 AI computing module, a beamforming six-microphone array, an 8-watt speaker, a pair of 13-megapixel cameras (wide angle and zoom) on a tilting mount, five ultrasonic rangefinders, and most excitingly, a pair of Intel RealSense D430 depth sensors.

It’s those new depth sensors that really make Double 3 special. The D430 modules each uses a pair of stereo cameras with a pattern projector to generate 1280 x 720 depth data with a range of between 0.2 and 10 meters away. The Double 3 robot uses all of this high quality depth data to locate obstacles, but at this point, it still doesn’t drive completely autonomously. Instead, it presents the remote operator with a slick, augmented reality view of drivable areas in the form of a grid of dots. You just click where you want the robot to go, and it will skillfully take itself there while avoiding obstacles (including dynamic obstacles) and related mishaps along the way.

This effectively offloads the most stressful part of telepresence—not running into stuff—from the remote user to the robot itself, which is the way it should be. That makes it that much easier to encourage people to utilize telepresence for the first time. The way the system is implemented through augmented reality is particularly impressive, I think. It looks like it’s intuitive enough for an inexperienced user without being restrictive, and is a clever way of mitigating even significant amounts of lag.

Otherwise, Double 3’s mobility system is exactly the same as the one featured on Double 2. In fact, that you can stick a Double 3 head on a Double 2 body and it instantly becomes a Double 3. Double Robotics is thoughtfully offering this to current Double 2 owners as a significantly more affordable upgrade option than buying a whole new robot.

For more details on all of Double 3's new features, we spoke with the co-founders of Double Robotics, Marc DeVidts and David Cann.

IEEE Spectrum: Why use this augmented reality system instead of just letting the user click on a regular camera image? Why make things more visually complicated, especially for new users?

Marc DeVidts and David Cann: One of the things that we realized about nine months ago when we got this whole thing working was that without the mixed reality for driving, it was really too magical of an experience for the customer. Even us—we had a hard time understanding whether the robot could really see obstacles and understand where the floor is and that kind of thing. So, we said “What would be the best way of communicating this information to the user?” And the right way to do it ended up drawing the graphics directly onto the scene. It’s really awesome—we have a full, real time 3D scene with the depth information drawn on top of it. We’re starting with some relatively simple graphics, and we’ll be adding more graphics in the future to help the user understand what the robot is seeing.

How robust is the vision system when it comes to obstacle detection and avoidance? Does it work with featureless surfaces, IR absorbent surfaces, in low light, in direct sunlight, etc?

We’ve looked at all of those cases, and one of the reasons that we’re going with the RealSense is the projector that helps us to see blank walls. We also found that having two sensors—one facing the floor and one facing forward—gives us a great coverage area. Having ultrasonic sensors in there as well helps us to detect anything that we can't see with the cameras. They're sort of a last safety measure, especially useful for detecting glass.

It seems like there’s a lot more that you could do with this sensing and mapping capability. What else are you working on?

We're starting with this semi-autonomous driving variant, and we're doing a private beta of full mapping. So, we’re going to do full SLAM of your environment that will be mapped by multiple robots at the same time while you're driving, and then you'll be able to zoom out to a map and click anywhere and it will drive there. That's where we're going with it, but we want to take baby steps to get there. It's the obvious next step, I think, and there are a lot more possibilities there.

Do you expect developers to be excited for this new mapping capability?

We're using a very powerful computer in the robot, a NVIDIA Jetson TX2 running Ubuntu. There's room to grow. It’s actually really exciting to be able to see, in real time, the 3D pose of the robot along with all of the depth data that gets transformed in real time into one view that gives you a full map. Having all of that data and just putting those pieces together and getting everything to work has been a huge feat in of itself.

We have an extensive API for developers to do custom implementations, either for telepresence or other kinds of robotics research. Our system isn't running ROS, but we're going to be adding ROS adapters for all of our hardware components.

Telepresence robots depend heavily on wireless connectivity, which is usually not something that telepresence robotics companies like Double have direct control over. Have you found that connectivity has been getting significantly better since you first introduced Double?

When we started in 2013, we had a lot of customers that didn’t have WiFi in their hallways, just in the conference rooms. We very rarely hear about customers having WiFi connectivity issues these days. The bigger issue we see is when people are calling into the robot from home, where they don't have proper traffic management on their home network. The robot doesn't need a ton of bandwidth, but it does need consistent, low latency bandwidth. And so, if someone else in the house is watching Netflix or something like that, it’s going to saturate your connection. But for the most part, it’s gotten a lot better over the last few years, and it’s no longer a big problem for us.

Do you think 5G will make a significant difference to telepresence robots?

We’ll see. We like the low latency possibilities and the better bandwidth, but it's all going to be a matter of what kind of reception you get. LTE can be great, if you have good reception; it’s all about where the tower is. I’m pretty sure that WiFi is going to be the primary thing for at least the next few years.

DeVidts also mentioned that an unfortunate side effect of the new depth sensors is that hanging a t-shirt on your Double to give it some personality will likely render it partially blind, so that's just something to keep in mind. To make up for this, you can switch around the colorful trim surrounding the screen, which is nowhere near as fun.

When the Double 3 is ready for shipping in late September, US $2,000 will get you the new head with all the sensors and stuff, which seamlessly integrates with your Double 2 base. Buying Double 3 straight up (with the included charging dock) will run you $4,ooo. This is by no means an inexpensive robot, and my impression is that it’s not really designed for individual consumers. But for commercial, corporate, healthcare, or education applications, $4k for a robot as capable as the Double 3 is really quite a good deal—especially considering the kinds of use cases for which it’s ideal.

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#434580 How Genome Sequencing and Senolytics Can ...

Posted on February 1, 2019 by Android

The causes of aging are extremely complex and unclear. With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to find practical ways to extend our healthspan.

Here, in Part 2 of a series of blogs on longevity and vitality, I explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

In this blog I’ll cover two classes of emerging technologies:

Genome Sequencing and Editing;
Senolytics, Nutraceuticals & Pharmaceuticals.

Let’s dive in.

Genome Sequencing & Editing
Your genome is the software that runs your body.

A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity to disease, your lifespan, and so on.

Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean.

Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $5,000 in 2012.

Today, the cost of genome sequencing has dropped below $500, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.

This represents one of the most powerful and transformative technology revolutions in healthcare.

When we understand your genome, we’ll be able to understand how to optimize “you.”

We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later blog).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).

CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally-occurring biological system discovered in 1987 called CRISPR/Cas9.

Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.

Here’s how it works:

The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays.
The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions.
If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.

Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome.

A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.

2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers from the University of Chicago recently used CRISPR to genetically engineer cocaine resistance into mice.

Researchers at the University of Texas Southwestern Medical Center used CRISPR to reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs (DMD is the most common fatal genetic disease in children).

With great power comes great responsibility, and moral and ethical dilemmas.

In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera.

Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.

To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells.

Setting aside the significant ethical conversations, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.

Senolytics, Nutraceuticals & Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.

What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely.

These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse.

Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification, to localized inflammatory conditions such as osteoarthritis, to diminished lung function.

Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.

Prominent companies in the field include the following:

Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology and pulmonary disease.
Oisin Biotechnologiesis pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.
SIWA Therapeuticsis working on an immunotherapy approach to the problem of senescent cells.

In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.

Rapamycin
Originally extracted from bacteria found on Easter Island, Rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division.

Currently, rapamycin derivatives are widely used as immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.

PureTech Health subsidiary resTORbio (which started 2018 by going public) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.

Results of the drug’s recent clinical trial include:

Decreased incidence of infection
Improved influenza vaccination response
A 30.6 percent decrease in respiratory tract infections

Impressive, to say the least.

Metformin
Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients.

Researchers have found that Metformin also reduces oxidative stress and inflammation, which otherwise increase as we age.

There is strong evidence that Metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.

Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of Metformin’s protective effect against cancer.

Nutraceuticals and NAD+
Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.

NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.

The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.

Conclusion
These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.

The next blog in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.

We are edging closer to a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?

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