Tag Archives: developing
#435793 Tiny Robots Carry Stem Cells Through a ...
Engineers have built microrobots to perform all sorts of tasks in the body, and can now add to that list another key skill: delivering stem cells. In a paper published today in Science Robotics, researchers describe propelling a magnetically-controlled, stem-cell-carrying bot through a live mouse.
Under a rotating magnetic field, the microrobots moved with rolling and corkscrew-style locomotion. The researchers, led by Hongsoo Choi and his team at the Daegu Gyeongbuk Institute of Science & Technology (DGIST), in South Korea, also demonstrated their bot’s moves in slices of mouse brain, in blood vessels isolated from rat brains, and in a multi-organ-on-a chip.
The invention provides an alternative way to deliver stem cells, which are increasingly important in medicine. Such cells can be coaxed into becoming nearly any kind of cell, making them great candidates for treating neurodegenerative disorders such as Alzheimer’s.
But delivering stem cells typically requires an injection with a needle, which lowers the survival rate of the stem cells, and limits their reach in the body. Microrobots, however, have the potential to deliver stem cells to precise, hard-to-reach areas, with less damage to surrounding tissue, and better survival rates, says Jin-young Kim, a principle investigator at DGIST-ETH Microrobotics Research Center, and an author on the paper.
The virtues of microrobots have inspired several research groups to propose and test different designs in simple conditions, such as microfluidic channels and other static environments. A group out of Hong Kong last year described a burr-shaped bot that carried cells through live, transparent zebrafish.
The new research presents a magnetically-actuated microrobot that successfully carried stem cells through a live mouse. In additional experiments, the cells, which had differentiated into brain cells such as astrocytes, oligodendrocytes, and neurons, transferred to microtissues on the multi-organ-on-a-chip. Taken together, the proof-of-concept experiments demonstrate the potential for microrobots to be used in human stem cell therapy, says Kim.
The team fabricated the robots with 3D laser lithography, and designed them in two shapes: spherical and helical. Using a rotating magnetic field, the scientists navigated the spherical-shaped bots with a rolling motion, and the helical bots with a corkscrew motion. These styles of locomotion proved more efficient than that from a simple pulling force, and were more suitable for use in biological fluids, the scientists reported.
The big challenge in navigating microbots in a live animal (or human body) is being able to see them in real time. Imaging with fMRI doesn’t work, because the magnetic fields interfere with the system. “To precisely control microbots in vivo, it is important to actually see them as they move,” the authors wrote in their paper.
That wasn’t possible during experiments in a live mouse, so the researchers had to check the location of the microrobots before and after the experiments using an optical tomography system called IVIS. They also had to resort to using a pulling force with a permanent magnet to navigate the microrobots inside the mouse, due to the limitations of the IVIS system.
Kim says he and his colleagues are developing imaging systems that will enable them to view in real time the locomotion of their microrobots in live animals. Continue reading
#435784 Amazon Uses 800 Robots to Run This ...
At Amazon’s re:MARS conference in Las Vegas today, who else but Amazon is introducing two new robots designed to make its fulfillment centers even more fulfilling. Xanthus (named after a mythological horse that could very briefly talk but let’s not read too much into that) is a completely redesigned drive unit, one of the robotic mobile bases that carries piles of stuff around for humans to pick from. It has a thinner profile, a third of the parts, costs half as much, and can wear different modules on top to perform a much wider variety of tasks than its predecessor.
Pegasus (named after a mythological horse that could fly but let’s not read too much into that either) is also a mobile robot, but much smaller than Xanthus, designed to help the company quickly and accurately sort individual packages. For Amazon, it’s a completely new large-scale robotic system involving tightly coordinated fleets of robots tossing boxes down chutes, and it’s just as fun to watch as it sounds.
Amazon has 800 Pegasus units already deployed at a sorting facility in the United States, adding to their newly updated total of 200,000 robotic drive units worldwide.
If the Pegasus system looks familiar, it’s because other warehouse automation companies have had something that’s at least superficially very similar up and running for years.
Photo: Amazon
Pegasus is one of Amazon’s new warehouse robots, equipped with a conveyor belt on top and used in the company’s sorting facilities.
But the most interesting announcement that Amazon made, kind of low key and right at the end of their re:MARS talk, is that they’re working on ways of making some of their mobile robots actually collaborative, leveraging some of the technology that they acquired from Boulder, Colo.-based warehouse robotics startup Canvas Technology earlier this year:
“With our recent acquisition of Canvas, we expect to be able to combine this drive platform with AI and autonomous mobility capabilities, and for the first time, allow our robots to move outside of our robotic drive fields, and interact collaboratively with our associates to do a number of mobility tasks,” said Brad Porter, VP of robotics at Amazon.
At the moment, Amazon’s robots are physically separated from humans except for one highly structured station where the human only interacts with the robot in one or two very specific ways. We were told a few months ago that Amazon would like to have mobile robots that are able to move things through the areas of fulfillment centers that have people in them, but that they’re (quite rightly) worried about the safety aspects of having robots and humans work around each other. Other companies are already doing this on a smaller scale, and it means developing a reliable safety system that can handle randomly moving humans, environmental changes, and all kinds of other stuff. It’s much more difficult than having a nice, clean, roped-off area to work in where a wayward human would be an exception rather than just another part of the job.
Photo: Canvas Technology
A robot created by Canvas Technology, a Boulder, Colo.-based warehouse robotics startup acquired by Amazon earlier this year.
It now seems like Canvas has provided the secret sauce that Amazon needed to start implementing this level of autonomy. As for what it’s going to look like, our best guess is that Amazon is going to have to do a little bit more than slap some extra sensors onto Xanthus or Pegasus, if for no other reason than the robots will almost certainly need more ground clearance to let them operate away from the reliably flat floors that they’re accustomed to. We’re expecting to see them performing many of the tasks that companies like Fetch Robotics and OTTO Motors are doing already—moving everything from small boxes to large pallets to keep humans from having to waste time walking.
Of course, this all feeds back into what drives Amazon more than anything else: efficiency. And for better or worse, humans are not uniquely good at moving things from place to place, so it’s no surprise that Amazon wants to automate that, too. The good news is that, at least for now, Amazon still needs humans to babysit all those robots.
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