Tag Archives: design

#437971 Video Friday: Teleport Yourself Into ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online]
RoboSoft 2021 – April 12-16, 2021 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.

Samsung announced some new prototype robots at CES this week. It's a fancy video, but my guess is that the actual autonomy here is minimal at best.

[ Samsung ]

Some very impressive reactive agility from Ghost Robotics' little quadruped.

[ Ghost Robotics ]

Toyota Research Institute (TRI) is researching how to bring together the instinctive reflexes of professional drivers and automated driving technology that uses the calculated foresight of a supercomputer. Using a Toyota GR Supra, TRI will learn from some of the most skilled drivers in the world to develop sophisticated vehicle control algorithms. The project’s goal is to design a new level of active safety technology for the Toyota Guardian™ approach of amplifying human driving abilities and helping keep people safe.

[ TRI ]

The end of this video features one of the most satisfying-sounding drone outtakes I've ever heard,

[ ASL ]

Reachy can now run the first humanoid VR teleoperation app available on the market. This app allows you to place yourself in the body of a humanoid robot, in VR, wherever you are in the world, to remotely operate it and carry out complex tasks. With this new functionality, Reachy is able to learn from the demonstration of the humans who control it, which makes application development even easier.

[ Pollen Robotics ]

Thanks Elsa!

Boston Dynamics has inspired some dancing robot videos recently, including this from Marco Tempest.

[ Marco Tempest ]

MOFLIN is an AI Pet created from a totally new concept. It possesses emotional capabilities that evolve like living animals. With its warm soft fur, cute sounds, and adorable movement, you’d want to love it forever. We took a nature inspired approach and developed a unique algorithm that allows MOFLIN to learn and grow by constantly using its interactions to determine patterns and evaluate its surroundings from its sensors. MOFLIN will choose from an infinite number of mobile and sound pattern combinations to respond and express its feelings. To put it in simple terms, it’s like you’re interacting with a living pet.

I like the minimalist approach. I dislike the “it’s like you’re interacting with a living pet” bit.

[ Kickstarter ]

There's a short gif of these warehouse robots going around, but here's the full video.

[ BionicHIVE ]

Vstone's Robovie-Z proves that you don't need fancy hardware for effective teleworking.

[ Vstone ]

All dual-arm robots are required, at some point, to play pool.

[ ABB ]

Volkswagen Group Components gives us a first glimpse of the real prototypes. This is one of the visionary charging concepts that Volkswagen hopes will expand the charging infrastructure over the next few years. Its task: fully autonomous charging of vehicles in restricted parking areas, like underground car parks.

To charge several vehicles at the same time, the mobile robot moves a trailer, essentially a mobile energy storage unit, to the vehicle, connects it up and then uses this energy storage unit to charge the battery of the electric vehicle. The energy storage unit stays with the vehicle during the charging process. In the meantime, the robot charges other electric vehicles.

[ Volkswagen ]

I've got a lot of questions about Moley Robotics' kitchen. But I would immediately point out that the system appears to do no prep work, which (at least for me) is the time-consuming and stressful part of cooking.

[ Moley Robotics ]

Blueswarm is a collective of fish-inspired miniature underwater robots that can achieve a wide variety of 3D collective behaviors – synchrony, aggregation/dispersion, milling, search – using only implicit communication mediated through the production and sensing of blue light. We envision this platform for investigating collective AI, underwater coordination, and fish-inspired locomotion and sensing.

[ Science Robotics ]

A team of Malaysian researchers are transforming pineapple leaves into strong materials that can be used to build frames for unmanned aircraft or drones.

[ Reuters ]

The future of facility disinfecting is here, protect your customers, and create peace of mind. Our drone sanitization spraying technology is up to 100% more efficient and effective than conventional manual spray sterilization processes.

[ Draganfly ]

Robots are no long a future technology, as small robots can be purchased today to be utilized for educational purposes. See what goes into making a modern robot come to life.

[ Huggbees ]

How does a robot dog learn how to dance? Adam and the Tested team examine and dive into Boston Dynamics' Choreographer software that was behind Spot's recent viral dancing video.

[ Tested ]

For years, engineers have had to deal with “the tyranny of the fairing,” that anything you want to send into space has to fit into the protective nosecone on top of the rocket. A field of advanced design has been looking for new ways to improve our engineering, using the centuries-old artform to dream bigger.

[ JPL ] Continue reading

Posted in Human Robots

#437918 Video Friday: These Robots Wish You ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

ICCR 2020 – December 26-29, 2020 – [Online]
HRI 2021 – March 8-11, 2021 – [Online]
RoboSoft 2021 – April 12-16, 2021 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.

Look who’s baaaack: Jibo! After being sold (twice?), this pioneering social home robot (it was first announced back in 2014!) now belongs to NTT Disruption, which was described to us as the “disruptive company of NTT Group.” We are all for disruption, so this looks like a great new home for Jibo.

[ NTT Disruption ]

Thanks Ana!

FZI's Christmas Party was a bit of a challenge this year; good thing robots are totally competent to have a part on their own.

[ FZI ]

Thanks Arne!

Do you have a lonely dog that just wants a friend to watch cat videos on YouTube with? The Danish Technological Institute has a gift idea for you.

[ DTI ]

Thanks Samuel!

Once upon a time, not so far away, there was an elf who received a very special gift. Watch this heartwarming story. Happy Holidays from the Robotiq family to yours!

Of course, these elves are not now unemployed, they've instead moved over to toy design full time!

[ Robotiq ]

An elegant Christmas video from the Dynamics System Lab, make sure and watch through the very end for a little extra cheer.

[ Dynamic Systems Lab ]

Thanks Angela!

Usually I complain when robotics companies make holiday videos without any real robots in them, but this is pretty darn cute from Yaskawa this year.

[ Yaskawa ]

Here's our little christmas gift to the fans of strange dynamic behavior. The gyro will follow any given shape as soon as the tip touches its edge and the rotation is fast enough. The friction between tip and shape generates a tangential force, creating a moment such that the gyroscopic reaction pushes the tip towards the shape. The resulting normal force produces a moment that guides the tip along the shape's edge.

[ TUM ]

Happy Holidays from Fanuc!

Okay but why does there have to be an assembly line elf just to put in those little cranks?

[ Fanuc ]

Astrobotic's cute little CubeRover is at NASA busy not getting stuck in places.

[ Astrobotic ]

Team CoSTAR is sharing more of their work on subterranean robotic exploration.

[ CoSTAR ]

Skydio Autonomy Enterprise Foundation (AEF), a new software product that delivers advanced AI-powered capabilities to assist the pilot during tactical situational awareness scenarios and detailed industrial asset inspections. Designed for professionals, it offers an enterprise-caliber flight experience through the new Skydio Enterprise application.

[ Skydio ]

GITAI's S1 autonomous robot will conduct two experiments: IVA (Intra-Vehicular Activity) tasks such as switch and cable operations, and assembly of structures and panels to demonstrate its capability for ISA (In-Space Assembly) tasks. This video was recorded in the Nanoracks Bishop Airlock mock-up facility @GITAI Tokyo office.

[ GITAI ]

It's no Atlas, but this is some impressive dynamic balancing from iCub.

[ IIT ]

The Campaign to Stop Killer Robots and I don't agree on a lot of things, and I don't agree with a lot of the assumptions made in this video, either. But, here you go!

[ CSKR ]

I don't know much about this robot, but I love it.

[ Columbia ]

Most cable-suspended robots have a very well defined workspace, but you can increase that workspace by swinging them around. Wheee!

[ Laval ]

How you know your robot's got some skill: “to evaluate the performance in climbing over the step, we compared the R.L. result to the results of 12 students who attempted to find the best planning. The RL outperformed all the group, in terms of effort and time, both in continuous (joystick) and partition planning.”

[ Zarrouk Lab ]

In the Spring 2021 semester, mechanical engineering students taking MIT class 2.007, Design and Manufacturing I, will be able to participate in the class’ iconic final robot competition from the comfort of their own home. Whether they take the class virtually or semi-virtually, students will be sent a massive kit of tools and materials to build their own unique robot along with a “Home Alone” inspired game board for the final global competition.

[ MIT ]

Well, this thing is still around!

[ Moley Robotics ]

Manuel Ahumada wrote in to share this robotic Baby Yoda that he put together with a little bit of help from Intel's OpenBot software.

[ YouTube ]

Thanks Manuel!

Here's what Zoox has been working on for the past half-decade.

[ Zoox ] Continue reading

Posted in Human Robots

#437912 “Boston Dynamics Will Continue to ...

Last week’s announcement that Hyundai acquired Boston Dynamics from SoftBank left us with a lot of questions. We attempted to answer many of those questions ourselves, which is typically bad practice, but sometimes it’s the only option when news like that breaks.

Fortunately, yesterday we were able to speak with Michael Patrick Perry, vice president of business development at Boston Dynamics, who candidly answered our questions about Boston Dynamics’ new relationship with Hyundai and what the near future has in store.

IEEE Spectrum: Boston Dynamics is worth 1.1 billion dollars! Can you put that valuation into context for us?

Michael Patrick Perry: Since 2018, we’ve shifted to becoming a commercial organization. And that’s included a number of things, like taking our existing technology and bringing it to market for the first time. We’ve gone from zero to 400 Spot robots deployed, building out an ecosystem of software developers, sensor providers, and integrators. With that scale of deployment and looking at the pipeline of opportunities that we have lined up over the next year, I think people have started to believe that this isn’t just a one-off novelty—that there’s actual value that Spot is able to create. Secondly, with some of our efforts in the logistics market, we’re getting really strong signals both with our Pick product and also with some early discussions around Handle’s deployment in warehouses, which we think are going to be transformational for that industry.

So, the thing that’s really exciting is that two years ago, we were talking about this vision, and people said, “Wow, that sounds really cool, let’s see how you do.” And now we have the validation from the market saying both that this is actually useful, and that we’re able to execute. And that’s where I think we’re starting to see belief in the long-term viability of Boston Dynamics, not just as a cutting-edge research shop, but also as a business.

Photo: Boston Dynamics

Boston Dynamics says it has deployed 400 Spot robots, building out an “ecosystem of software developers, sensor providers, and integrators.”

How would you describe Hyundai’s overall vision for the future of robotics, and how do they want Boston Dynamics to fit into that vision?

In the immediate term, Hyundai’s focus is to continue our existing trajectories, with Spot, Handle, and Atlas. They believe in the work that we’ve done so far, and we think that combining with a partner that understands many of the industries in which we’re targeting, whether its manufacturing, construction, or logistics, can help us improve our products. And obviously as we start thinking about producing these robots at scale, Hyundai’s expertise in manufacturing is going to be really helpful for us.

Looking down the line, both Boston Dynamics and Hyundai believe in the value of smart mobility, and they’ve made a number of plays in that space. Whether it’s urban air mobility or autonomous driving, they’ve been really thinking about connecting the digital and the physical world through moving systems, whether that’s a car, a vertical takeoff and landing multi-rotor vehicle, or a robot. We are well positioned to take on robotics side of that while also connecting to some of these other autonomous services.

Can you tell us anything about the kind of robotics that the Hyundai Motor Group has going on right now?

So they’re working on a lot of really interesting stuff—exactly how that connects, you know, it’s early days, and we don’t have anything explicitly to share. But they’ve got a smart and talented robotics team that’s working in a variety of directions that shares overlap with us. Obviously, a lot of things related to autonomous driving shares some DNA with the work that we’re doing in autonomy for Spot and Handle, so it’s pretty exciting to see.

What are you most excited about here? How do you think this deal will benefit Boston Dynamics?

I think there are a number of things. One is that they have an expertise in hardware, in a way that’s unique. They understand and appreciate the complexity of creating large complex robotic systems. So I think there’s some shared understanding of what it takes to create a great hardware product. And then also they have the resources to help us actually build those products with them together—they have manufacturing resources and things like that.

“Robotics isn’t a short term game. We’ve scaled pretty rapidly but if you start looking at what the full potential of a company like Boston Dynamics is, it’s going to take years to realize, and I think Hyundai is committed to that long-term vision”

Another thing that’s exciting is that Hyundai has some pretty visionary bets for autonomous driving and unmanned aerial systems, and all of that fits very neatly into the connected vision of robotics that we were talking about before. Robotics isn’t a short term game. We’ve scaled pretty rapidly for a robotics company in terms of the scale of robots we’ve able to deploy in the field, but if you start looking at what the full potential of a company like Boston Dynamics is, it’s going to take years to realize, and I think Hyundai is committed to that long-term vision.

And when you’ve been talking with Hyundai, what are they most excited about?

I think they’re really excited about our existing products and our technology. Looking at some of the things that Spot, Pick, and Handle are able to do now, there are applications that many of Hyundai’s customers could benefit from in terms of mobility, remote sensing, and material handling. Looking down the line, Hyundai is also very interested in smart city technology, and mobile robotics is going to be a core piece of that.

We tend to focus on Spot and Handle and Atlas in terms of platform capabilities, but can you talk a bit about some of the component-level technology that’s unique to Boston Dynamics, and that could be of interest to Hyundai?

Creating very power-dense actuator design is something that we’ve been successful at for several years, starting back with BigDog and LS3. And Handle has some hydraulic actuators and valves that are pretty unique in terms of their design and capability. Fundamentally, we have a systems engineering approach that brings together both hardware and software internally. You’ll often see different groups that specialize in something, like great mechanical or electrical engineering groups, or great controls teams, but what I think makes Boston Dynamics so special is that we’re able to put everything on the table at once to create a system that’s incredibly capable. And that’s why with something like Spot, we’re able to produce it at scale, while also making it flexible enough for all the different applications that the robot is being used for right now.

It’s hard to talk specifics right now, but there are obviously other disciplines within mechanical engineering or electrical engineering or controls for robots or autonomous systems where some of our technology could be applied.

Photo: Boston Dynamics

Boston Dynamics is in the process of commercializing Handle, iterating on its design and planning to get box-moving robots on-site with customers in the next year or two.

While Boston Dynamics was part of Google, and then SoftBank, it seems like there’s been an effort to maintain independence. Is it going to be different with Hyundai? Will there be more direct integration or collaboration?

Obviously it’s early days, but right now, we have support to continue executing against all the plans that we have. That includes all the commercialization of Spot, as well as things for Atlas, which is really going to be pushing the capability of our team to expand into new areas. That’s going to be our immediate focus, and we don’t see anything that’s going to pull us away from that core focus in the near term.

As it stands right now, Boston Dynamics will continue to be Boston Dynamics under this new ownership.

How much of what you do at Boston Dynamics right now would you characterize as fundamental robotics research, and how much is commercialization? And how do you see that changing over the next couple of years?

We have been expanding our commercial team, but we certainly keep a lot of the core capabilities of fundamental robotics research. Some of it is very visible, like the new behavior development for Atlas where we’re pushing the limits of perception and path planning. But a lot of the stuff that we’re working on is a little bit under the hood, things that are less obvious—terrain handling, intervention handling, how to make safe faults, for example. Initially when Spot started slipping on things, it would flail around trying to get back up. We’ve had to figure out the right balance between the robot struggling to stand, and when it should decide to just lock its limbs and fall over because it’s safer to do that.

I’d say the other big thrust for us is manipulation. Our gripper for Spot is coming out early next year, and that’s going to unlock a new set of capabilities for us. We have years and years of locomotion experience, but the ability to manipulate is a space that’s still relatively new to us. So we’ve been ramping up a lot of work over the last several years trying to get to an early but still valuable iteration of the technology, and we’ll continue pushing on that as we start learning what’s most useful to our customers.

“I’d say the other big thrust for us is manipulation. Our gripper for Spot is coming out early next year, and that’s going to unlock a new set of capabilities for us. We have years and years of locomotion experience, but the ability to manipulate is a space that’s still relatively new to us”

Looking back, Spot as a commercial robot has a history that goes back to robots like LS3 and BigDog, which were very ambitious projects funded by agencies like DARPA without much in the way of commercial expectations. Do you think these very early stage, very expensive, very technical projects are still things that Boston Dynamics can take on?

Yes—I would point to a lot of the things we do with Atlas as an example of that. While we don’t have immediate plans to commercialize Atlas, we can point to technologies that come out of Atlas that have enabled some of our commercial efforts over time. There’s not necessarily a clear roadmap of how every piece of Atlas research is going to feed over into a commercial product; it’s more like, this is a really hard fundamental robotics challenge, so let’s tackle it and learn things that we can then benefit from across the company.

And fundamentally, our team loves doing cool stuff with robots, and you’ll continue seeing that in the months to come.

Photo: Boston Dynamics

Spot’s arm with gripper is coming out early next year, and Boston Dynamics says that’s going to “unlock a new set of capabilities for us.”

What would it take to commercialize Atlas? And are you getting closer with Handle?

We’re in the process of commercializing Handle. We’re at a relatively early stage, but we have a plan to get the first versions for box moving on-site with customers in the next year or two. Last year, we did some on-site deployments as proof-of-concept trials, and using the feedback from that, we did a new design pass on the robot, and we’re looking at increasing our manufacturing capability. That’s all in progress.

For Atlas, it’s like the Formula 1 of robots—you’re not going to take a Formula 1 car and try to make it less capable so that you can drive it on the road. We’re still trying to see what are some applications that would necessitate an energy and computationally intensive humanoid robot as opposed to something that’s more inherently stable. Trying to understand that application space is something that we’re interested in, and then down the line, we could look at creating new morphologies to help address specific applications. In many ways, Handle is the first version of that, where we said, “Atlas is good at moving boxes but it’s very complicated and expensive, so let’s create a simpler and smaller design that can achieve some of the same things.”

The press release mentioned a mobile robot for warehouses that will be introduced next year—is that Handle?

Yes, that’s the work that we’re doing on Handle.

As we start thinking about a whole robotic solution for the warehouse, we have to look beyond a high power, low footprint, dynamic platform like Handle and also consider things that are a little less exciting on video. We need a vision system that can look at a messy stack of boxes and figure out how to pick them up, we need an interface between a robot and an order building system—things where people might question why Boston Dynamics is focusing on them because it doesn’t fit in with our crazy backflipping robots, but it’s really incumbent on us to create that full end-to-end solution.

Are you confident that under Hyundai’s ownership, Boston Dynamics will be able to continue taking the risks required to remain on the cutting edge of robotics?

I think we will continue to push the envelope of what robots are capable of, and I think in the near term, you’ll be able to see that realized in our products and the research that we’re pushing forward with. 2021 is going to be a great year for us. Continue reading

Posted in Human Robots

#437882 Video Friday: MIT Mini-Cheetah Robots ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

ICCR 2020 – December 26-29, 2020 – [Online Conference]
HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
Let us know if you have suggestions for next week, and enjoy today's videos.

What a lovely Christmas video from Norlab.

[ Norlab ]

Thanks Francois!

MIT Mini-Cheetahs are looking for a new home. Our new cheetah cubs, born at NAVER LABS, are for the MIT Mini-Cheetah workshop. MIT professor Sangbae Kim and his research team are supporting joint research by distributing Mini-Cheetahs to researchers all around the world.

[ NAVER Labs ]

For several years, NVIDIA’s research teams have been working to leverage GPU technology to accelerate reinforcement learning (RL). As a result of this promising research, NVIDIA is pleased to announce a preview release of Isaac Gym – NVIDIA’s physics simulation environment for reinforcement learning research. RL-based training is now more accessible as tasks that once required thousands of CPU cores can now instead be trained using a single GPU.

[ NVIDIA ]

At SINTEF in Norway, they're working on ways of using robots to keep tabs on giant floating cages of tasty fish:

One of the tricky things about operating robots in an environment like this is localization, so SINTEF is working on a solution that uses beacons:

While that video shows a lot of simulation (because otherwise there are tons of fish in the way), we're told that the autonomous navigation has been successfully demonstrated with an ROV in “a full scale fish farm with up to 200.000 salmon swimming around the robot.”

[ SINTEF ]

Thanks Eleni!

We’ve been getting ready for the snow in the most BG way possible. Wishing all of you a happy and healthy holiday season.

[ Berkshire Grey ]

ANYbotics doesn’t care what time of the year it is, so Happy Easter!

And here's a little bit about why ANYmal C looks the way it does.

[ ANYbotics ]

Robert “Buz” Chmielewski is using two modular prosthetic limbs developed by APL to feed himself dessert. Smart software puts his utensils in roughly the right spot, and then Buz uses his brain signals to cut the food with knife and fork. Once he is done cutting, the software then brings the food near his mouth, where he again uses brain signals to bring the food the last several inches to his mouth so that he can eat it.

[ JHUAPL ]

Introducing VESPER: a new military-grade small drone that is designed, sourced and built in the United States. Vesper offers a 50-minutes flight time, with speeds up to 45 mph (72 kph) and a total flight range of 25 miles (45 km). The magnetic snap-together architecture enables extremely fast transitions: the battery, props and rotor set can each be swapped in <5 seconds.

[ Vantage Robotics ]

In this video, a multi-material robot simulator is used to design a shape-changing robot, which is then transferred to physical hardware. The simulated and real robots can use shape change to switch between rolling gaits and inchworm gaits, to locomote in multiple environments.

[ Yale Faboratory ]

Get a preview of the cave environments that are being used to inspire the Final Event competition course of the DARPA Subterranean Challenge. In the Final Event, teams will deploy their robots to rapidly map, navigate, and search in competition courses that combine elements of man-made tunnel systems, urban underground, and natural cave networks!

The reason to pay attention this particular video is that it gives us some idea of what DARPA means when they say "cave."

[ SubT ]

MQ25 takes another step toward unmanned aerial refueling for the U.S. Navy. The MQ-25 test asset has flown for the first time with an aerial refueling pod containing the hose and basket that will make it an aerial refueler.

[ Boeing ]

We present a unified model-based and data-driven approach for quadrupedal planning and control to achieve dynamic locomotion over uneven terrain. We utilize on-board proprioceptive and exteroceptive feedback to map sensory information and desired base velocity commands into footstep plans using a reinforcement learning (RL) policy trained in simulation over a wide range of procedurally generated terrains.

[ DRS ]

The video shows the results of the German research project RoPHa. Within the project, the partners developed technologies for two application scenarios with the service robot Care-O-bot 4 in order to support people in need of help when eating.

[ RoPHa Project ]

Thanks Jenny!

This looks like it would be fun, if you are a crazy person.

[ Team BlackSheep ]

Robot accuracy is the limiting factor in many industrial applications. Manufacturers often only specify the pose repeatability values of their robotic systems. Fraunhofer IPA has set up a testing environment for automated measuring of accuracy performance criteria of industrial robots. Following the procedures defined in norm ISO 9283 allows generating reliable and repeatable results. They can be the basis for targeted measures increasing the robotic system’s accuracy.

[ Fraunhofer ]

Thanks Jenny!

The IEEE Women in Engineering – Robotics and Automation Society (WIE-RAS) hosted an online panel on best practices for teaching robotics. The diverse panel boasts experts in robotics education from a variety of disciplines, institutions, and areas of expertise.

[ IEEE RAS ]

Northwestern researchers have developed a first-of-its-kind soft, aquatic robot that is powered by light and rotating magnetic fields. These life-like robotic materials could someday be used as "smart" microscopic systems for production of fuels and drugs, environmental cleanup or transformative medical procedures.

[ Northwestern ]

Tech United Eindhoven's soccer robots now have eight wheels instead of four wheels, making them tweleve times better, if my math is right.

[ TU Eindhoven ] Continue reading

Posted in Human Robots

#437872 AlphaFold Proves That AI Can Crack ...

Any successful implementation of artificial intelligence hinges on asking the right questions in the right way. That’s what the British AI company DeepMind (a subsidiary of Alphabet) accomplished when it used its neural network to tackle one of biology’s grand challenges, the protein-folding problem. Its neural net, known as AlphaFold, was able to predict the 3D structures of proteins based on their amino acid sequences with unprecedented accuracy.

AlphaFold’s predictions at the 14th Critical Assessment of protein Structure Prediction (CASP14) were accurate to within an atom’s width for most of the proteins. The competition consisted of blindly predicting the structure of proteins that have only recently been experimentally determined—with some still awaiting determination.

Called the building blocks of life, proteins consist of 20 different amino acids in various combinations and sequences. A protein's biological function is tied to its 3D structure. Therefore, knowledge of the final folded shape is essential to understanding how a specific protein works—such as how they interact with other biomolecules, how they may be controlled or modified, and so on. “Being able to predict structure from sequence is the first real step towards protein design,” says Janet M. Thornton, director emeritus of the European Bioinformatics Institute. It also has enormous benefits in understanding disease-causing pathogens. For instance, at the moment only about 18 of the 26 proteins in the SARS-CoV-2 virus are known.

Predicting a protein’s 3D structure is a computational nightmare. In 1969 Cyrus Levinthal estimated that there are 10300 possible conformational combinations for a single protein, which would take longer than the age of the known universe to evaluate by brute force calculation. AlphaFold can do it in a few days.

As scientific breakthroughs go, AlphaFold’s discovery is right up there with the likes of James Watson and Francis Crick’s DNA double-helix model, or, more recently, Jennifer Doudna and Emmanuelle Charpentier’s CRISPR-Cas9 genome editing technique.

How did a team that just a few years ago was teaching an AI to master a 3,000-year-old game end up training one to answer a question plaguing biologists for five decades? That, says Briana Brownell, data scientist and founder of the AI company PureStrategy, is the beauty of artificial intelligence: The same kind of algorithm can be used for very different things.

“Whenever you have a problem that you want to solve with AI,” she says, “you need to figure out how to get the right data into the model—and then the right sort of output that you can translate back into the real world.”

DeepMind’s success, she says, wasn’t so much a function of picking the right neural nets but rather “how they set up the problem in a sophisticated enough way that the neural network-based modeling [could] actually answer the question.”

AlphaFold showed promise in 2018, when DeepMind introduced a previous iteration of their AI at CASP13, achieving the highest accuracy among all participants. The team had trained its to model target shapes from scratch, without using previously solved proteins as templates.

For 2020 they deployed new deep learning architectures into the AI, using an attention-based model that was trained end-to-end. Attention in a deep learning network refers to a component that manages and quantifies the interdependence between the input and output elements, as well as between the input elements themselves.

The system was trained on public datasets of the approximately 170,000 known experimental protein structures in addition to databases with protein sequences of unknown structures.

“If you look at the difference between their entry two years ago and this one, the structure of the AI system was different,” says Brownell. “This time, they’ve figured out how to translate the real world into data … [and] created an output that could be translated back into the real world.”

Like any AI system, AlphaFold may need to contend with biases in the training data. For instance, Brownell says, AlphaFold is using available information about protein structure that has been measured in other ways. However, there are also many proteins with as yet unknown 3D structures. Therefore, she says, a bias could conceivably creep in toward those kinds of proteins that we have more structural data for.

Thornton says it’s difficult to predict how long it will take for AlphaFold’s breakthrough to translate into real-world applications.

“We only have experimental structures for about 10 per cent of the 20,000 proteins [in] the human body,” she says. “A powerful AI model could unveil the structures of the other 90 per cent.”

Apart from increasing our understanding of human biology and health, she adds, “it is the first real step toward… building proteins that fulfill a specific function. From protein therapeutics to biofuels or enzymes that eat plastic, the possibilities are endless.” Continue reading

Posted in Human Robots