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Once upon a time, a powerful Sumerian king named Gilgamesh went on a quest, as such characters often do in these stories of myth and legend. Gilgamesh had witnessed the death of his best friend, Enkidu, and, fearing a similar fate, went in search of immortality. The great king failed to find the secret of eternal life but took solace that his deeds would live well beyond his mortal years.
Fast-forward four thousand years, give or take a century, and Gilgamesh (as famous as any B-list celebrity today, despite the passage of time) would probably be heartened to learn that many others have taken up his search for longevity. Today, though, instead of battling epic monsters and the machinations of fickle gods, those seeking to enhance and extend life are cutting-edge scientists and visionary entrepreneurs who are helping unlock the secrets of human biology.
Chief among them is Aubrey de Grey, a biomedical gerontologist who founded the SENS Research Foundation, a Silicon Valley-based research organization that seeks to advance the application of regenerative medicine to age-related diseases. SENS stands for Strategies for Engineered Negligible Senescence, a term coined by de Grey to describe a broad array (seven, to be precise) of medical interventions that attempt to repair or prevent different types of molecular and cellular damage that eventually lead to age-related diseases like cancer and Alzheimer’s.
Many of the strategies focus on senescent cells, which accumulate in tissues and organs as people age. Not quite dead, senescent cells stop dividing but are still metabolically active, spewing out all sorts of proteins and other molecules that can cause inflammation and other problems. In a young body, that’s usually not a problem (and probably part of general biological maintenance), as a healthy immune system can go to work to put out most fires.
However, as we age, senescent cells continue to accumulate, and at some point the immune system retires from fire watch. Welcome to old age.
Of Mice and Men
Researchers like de Grey believe that treating the cellular underpinnings of aging could not only prevent disease but significantly extend human lifespans. How long? Well, if you’re talking to de Grey, Biblical proportions—on the order of centuries.
De Grey says that science has made great strides toward that end in the last 15 years, such as the ability to copy mitochondrial DNA to the nucleus. Mitochondria serve as the power plant of the cell but are highly susceptible to mutations that lead to cellular degeneration. Copying the mitochondrial DNA into the nucleus would help protect it from damage.
Another achievement occurred about six years ago when scientists first figured out how to kill senescent cells. That discovery led to a spate of new experiments in mice indicating that removing these ticking-time-bomb cells prevented disease and even extended their lifespans. Now the anti-aging therapy is about to be tested in humans.
“As for the next few years, I think the stream of advances is likely to become a flood—once the first steps are made, things get progressively easier and faster,” de Grey tells Singularity Hub. “I think there’s a good chance that we will achieve really dramatic rejuvenation of mice within only six to eight years: maybe taking middle-aged mice and doubling their remaining lifespan, which is an order of magnitude more than can be done today.”
Not Horsing Around
Richard G.A. Faragher, a professor of biogerontology at the University of Brighton in the United Kingdom, recently made discoveries in the lab regarding the rejuvenation of senescent cells with chemical compounds found in foods like chocolate and red wine. He hopes to apply his findings to an animal model in the future—in this case,horses.
“We have been very fortunate in receiving some funding from an animal welfare charity to look at potential treatments for older horses,” he explains to Singularity Hub in an email. “I think this is a great idea. Many aspects of the physiology we are studying are common between horses and humans.”
What Faragher and his colleagues demonstrated in a paper published in BMC Cell Biology last year was that resveralogues, chemicals based on resveratrol, were able to reactivate a protein called a splicing factor that is involved in gene regulation. Within hours, the chemicals caused the cells to rejuvenate and start dividing like younger cells.
“If treatments work in our old pony systems, then I am sure they could be translated into clinical trials in humans,” Faragher says. “How long is purely a matter of money. Given suitable funding, I would hope to see a trial within five years.”
Show Them the Money
Faragher argues that the recent breakthroughs aren’t because a result of emerging technologies like artificial intelligence or the gene-editing tool CRISPR, but a paradigm shift in how scientists understand the underpinnings of cellular aging. Solving the “aging problem” isn’t a question of technology but of money, he says.
“Frankly, when AI and CRISPR have removed cystic fibrosis, Duchenne muscular dystrophy or Gaucher syndrome, I’ll be much more willing to hear tales of amazing progress. Go fix a single, highly penetrant genetic disease in the population using this flashy stuff and then we’ll talk,” he says. “My faith resides in the most potent technological development of all: money.”
De Grey is less flippant about the role that technology will play in the quest to defeat aging. AI, CRISPR, protein engineering, advances in stem cell therapies, and immune system engineering—all will have a part.
“There is not really anything distinctive about the ways in which these technologies will contribute,” he says. “What’s distinctive is that we will need all of these technologies, because there are so many different types of damage to repair and they each require different tricks.”
It’s in the Blood
A startup in the San Francisco Bay Area believes machines can play a big role in discovering the right combination of factors that lead to longer and healthier lives—and then develop drugs that exploit those findings.
BioAge Labs raised nearly $11 million last year for its machine learning platform that crunches big data sets to find blood factors, such as proteins or metabolites, that are tied to a person’s underlying biological age. The startup claims that these factors can predict how long a person will live.
“Our interest in this comes out of research into parabiosis, where joining the circulatory systems of old and young mice—so that they share the same blood—has been demonstrated to make old mice healthier and more robust,” Dr. Eric Morgen, chief medical officer at BioAge, tells Singularity Hub.
Based on that idea, he explains, it should be possible to alter those good or bad factors to produce a rejuvenating effect.
“Our main focus at BioAge is to identify these types of factors in our human cohort data, characterize the important molecular pathways they are involved in, and then drug those pathways,” he says. “This is a really hard problem, and we use machine learning to mine these complex datasets to determine which individual factors and molecular pathways best reflect biological age.”
Saving for the Future
Of course, there’s no telling when any of these anti-aging therapies will come to market. That’s why Forever Labs, a biotechnology startup out of Ann Arbor, Michigan, wants your stem cells now. The company offers a service to cryogenically freeze stem cells taken from bone marrow.
The theory behind the procedure, according to Forever Labs CEO Steven Clausnitzer, is based on research showing that stem cells may be a key component for repairing cellular damage. That’s because stem cells can develop into many different cell types and can divide endlessly to replenish other cells. Clausnitzer notes that there are upwards of a thousand clinical studies looking at using stem cells to treat age-related conditions such as cardiovascular disease.
However, stem cells come with their own expiration date, which usually coincides with the age that most people start experiencing serious health problems. Stem cells harvested from bone marrow at a younger age can potentially provide a therapeutic resource in the future.
“We believe strongly that by having access to your own best possible selves, you’re going to be well positioned to lead healthier, longer lives,” he tells Singularity Hub.
“There’s a compelling argument to be made that if you started to maintain the bone marrow population, the amount of nuclear cells in your bone marrow, and to re-up them so that they aren’t declining with age, it stands to reason that you could absolutely mitigate things like cardiovascular disease and stroke and Alzheimer’s,” he adds.
Clausnitzer notes that the stored stem cells can be used today in developing therapies to treat chronic conditions such as osteoarthritis. However, the more exciting prospect—and the reason he put his own 38-year-old stem cells on ice—is that he believes future stem cell therapies can help stave off the ravages of age-related disease.
“I can start reintroducing them not to treat age-related disease but to treat the decline in the stem-cell niche itself, so that I don’t ever get an age-related disease,” he says. “I don’t think that it equates to immortality, but it certainly is a step in that direction.”
Indecisive on Immortality
The societal implications of a longer-living human species are a guessing game at this point. We do know that by mid-century, the global population of those aged 65 and older will reach 1.6 billion, while those older than 80 will hit nearly 450 million, according to the National Academies of Science. If many of those people could enjoy healthy lives in their twilight years, an enormous medical cost could be avoided.
Faragher is certainly working toward a future where human health is ubiquitous. Human immortality is another question entirely.
“The longer lifespans become, the more heavily we may need to control birth rates and thus we may have fewer new minds. This could have a heavy ‘opportunity cost’ in terms of progress,” he says.
And does anyone truly want to live forever?
“There have been happy moments in my life but I have also suffered some traumatic disappointments. No [drug] will wash those experiences out of me,” Faragher says. “I no longer view my future with unqualified enthusiasm, and I do not think I am the only middle-aged man to feel that way. I don’t think it is an accident that so many ‘immortalists’ are young.
“They should be careful what they wish for.”
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This week we’ve rolled out our first major round of improvements to Singularity Hub since our ground-up redesign last December. If we did it right, you’ll find that discovering the technological goodies you come here for is much easier, and so too are other Singularity University offerings you might be interested in.
The first and most major change is in the way Hub’s navigation is structured.
The previous categories in our header (Tech, Future, Health, Science) have been replaced by a single page, Topics, which profiles the most popular tech topics across our site. The featured topics in this menu will be updated regularly based on article performance, so you can keep up with what’s trending in AI, biotech, neuroscience, robotics, or whatever is making the biggest splash most recently.
Rolling our hottest topic category tags into one header dropdown allowed us to create greater focus on some of our newest and best offerings.
Our header now prominently features In Focus, which includes articles on how leaders can make the most of today’s accelerating pace of change by learning to think like futurists, innovators, technologists, and humanitarians. We’ve always been technological optimists, and we want to to make it easy for leaders to find the stories that help make hopeful problem-solvers of us all.
We’ve added a section for Experts, which features leaders in the Singularity University community and showcases their thought leadership including interviews and books. In Events, we highlight Singularity University’s global library of local happenings and summits.
Lastly, we’re excited that our growing original video efforts—from our Ray Kurzweil series to our weekly tech news roundup posts—now live under a central Videos section on Hub. This also gives us a place to highlight our favorite video posts from around the web, including the sci-fi shorts we love so much.
Cruising through the rest of Hub, particularly our homepage, you’ll find a much greater variety of content options, including new stories, top stories, event coverage, and videos. In short, it’s everything a homepage should be. On posts, we’ve tried to keep things as clean as possible, and we put a lot of hours into laboriously streamlining our content tagging structure, making it much easier for you to click through category tags into other stories you might like.
Here’s what @singularityhub looked like 2 years ago, 2 weeks ago, & today. Check it out: https://t.co/7cmlTJwc7d pic.twitter.com/jDayIEIFNv
— Singularity Hub (@singularityhub) July 13, 2017
You’ll also see greater visibility into Singularity University events, along with clearer ways to keep up with Hub and SU both, from simple email newsletter signups to callouts for the SingularityU Hub iOS app and events like SU’s Experts on Air series.
We hope you enjoy the ever-evolving, ever-improving Singularity Hub, and we’d love to hear your feedback. Feel free to tweet us, and let us know your thoughts. You can also pitch us or email us. And as always, thank you for your support. Continue reading
Tech-Link Healthcare Systems partners with Blue Ocean Robotics Introducing UV-Disinfection Robot
Singapore, 1 November 2016 – The rise of robots have steered Tech-Link Healthcare Systems, a design and integrator of healthcare automation systems to offer solutions beyond automated storage and material handling systems. With a vision of providing holistic solutions for healthcare organisations, Tech-Link extends its capabilities by offering UV disinfection robot solutions via a strategic partnership with Danish robotics company, Blue Ocean Robotics to battle against Hospital Acquired Infections (HAIs).Singapore’s labour intensive healthcare environment and the unknown impact of HAIs in the developed city-state had beckoned Tech-Link Healthcare Systems to offer solutions in the area of disinfection. We recognised the rise in demand for robots to collaborate with humans and have identified this need for customers. Introducing robotic technologies as part of our suite of solutions is the company’s mission to innovate the way healthcare organisations work and enhance their customers’ experience.Tech-Link’s partnership with Blue Ocean Robotics affirms both companies’ efforts in reaching out to new markets with technology and solutions to ease manpower crunch, deliver greater value and improve the quality of healthcare services. As an official sales partner, we bring together Blue Ocean Robotics’ expertise in automating disinfection procedures to promote safer, efficient and more productive work environment.
“Tech-Link looks forward to developing reliable healthcare solutions with hardware and latest technologies from Blue Ocean Robotics for our customers in Singapore and abroad.” said Director of Tech-Link Healthcare Systems, Tan Hock Seng. “Our similar beliefs in the Blue Ocean strategy synergise the collaboration to improve the quality of healthcare services through robotics.” he added.“We are very excited about our new sales partner Tech-Link Healthcare Systems, since it is of great importance for Blue Ocean Robotics to expand our sales of new technologies beyond Denmark’s borders. Blue Ocean Robotics focuses on creating new markets for robots. This includes both the development of new technologies and the creation of new markets for revolutionary robot solutions. We welcome Tech-Link Healthcare Systems with open arms and look forward to a fruitful collaboration in the years ahead.” said Claus Risager, Rune K. Larsen & John Erland Østergaard, Partners and Co-CEOs, Blue Ocean Robotics.
UV-Disinfection RobotThe UV-Disinfection Robot – also called UV-DR – is an autonomous disinfection robot for hospitals, production lines and pharmaceutical companies. The robot is used primarily in, but not limited to the cleaning cycle with the aim of reducing spread of HAIs, infectious diseases, viruses, bacteria and other types or harmful organic materials.UV-DR is a mobile robot that can drive autonomously while emitting concentrated UV-C light onto pre-defined infectious hotspots in patient rooms and other hospital environments, thus disinfecting and killing bacteria and virus on all exposed surfaces. An exposure time of ten minutes is estimated to kill up to 99% of bacteria such as Clostridium Difficile.
About Tech-Link Healthcare Systems Pte LtdTech-Link Healthcare Systems is a subsidiary of Tech-Link Storage Engineering established in Singapore since 2015. The company designs and provides innovative solutions for the healthcare sector, focusing on advanced and emerging solutions to support healthcare organisations in optimising available resources and services. Tech-Link Healthcare Systems design and implement automated material handling systems to enhance secured material transport and logistics storage management in hospitals and other healthcare facilities. As a complete solution provider, the company also provides consultancy in systems design to streamline and automate processes as well as integrated video solutions within healthcare facilities.About Tech-Link Storage Engineering Pte LtdTech-Link Storage Engineering is a group of companies established in Singapore with more than 25 years of principal activities in procurement, manufacturing and marketing of storage, distribution and materials handling products and systems. From its domain expertise in storage and racking systems, Tech-Link is also involved in R&D, system design, supply and implementation of logistics supply chain automation systems. The business expanded its global capabilities in the area of planning and consultancy to provide solutions for Built-to-Suit industrial developments and Healthcare logistics systems.
Tech-Link is an ISO 9001:2008 and OHSAS 18001:2007 certified company for Quality Management System and Occupational, Health and Safety System.Visit www.techlinkstorageengineering.comAbout Blue Ocean RoboticsBlue Ocean Robotics is an international company group with presence across the globe including America, Europe, Asia and Australia. The robotics company has its headquarter in the city of Odense (www.odenserobotics.dk) in Denmark. Blue Ocean Robotics applies robot technology to create solutions and innovation for end-users and new businesses in partnerships.Visit www.blue-ocean-robotics.com
Here is a video showing the robot in action:
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