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#432539 10 Amazing Things You Can Learn From ...

Hardly a day goes by without a research study or article published talking sh*t—or more precisely, talking about the gut microbiome. When it comes to cutting-edge innovations in medicine, all signs point to the microbiome. Maybe we should have listened to Hippocrates: “All disease begins in the gut.”

Your microbiome is mostly located in your gut and contains trillions of little guys and gals called microbes. If you want to optimize your health, biohack your body, make progress against chronic disease, or know which foods are right for you—almost all of this information can be found in your microbiome.

My company, Viome, offers technology to measure your microscopic organisms and their behavior at a molecular level. Think of it as the Instagram of your inner world. A snapshot of what’s happening inside your body. New research about the microbiome is changing our understanding of who we are as humans and how the human body functions.

It turns out the microbiome may be mission control for your body and mind. Your healthy microbiome is part best friend, part power converter, part engine, and part pharmacist. At Viome, we’re working to analyze these microbial functions and recommend a list of personalized food and supplements to keep these internal complex machines in a finely tuned balance.

We now have more information than ever before about what your microbiome is doing, and it’s going to help you and the rest of the world do a whole lot better. The new insights emerging from microbiome research are changing our perception of what keeps us healthy and what makes us sick. This new understanding of the microbiome activities may put an end to conflicting food advice and make fad diets a thing of the past.

What are these new insights showing us? The information is nothing short of mind-blowing. The value of your poop just got an upgrade.

Here are some of the amazing things we’ve learned from our work at Viome.

1. Was Popeye wrong? Why “health food” isn’t necessarily healthy.
Each week there is a new fad diet released, discussed, and followed. The newest “research” shows that this is now the superfood to eat for everyone. But, too often, the fad diet is just a regurgitation of what worked for one person and shouldn’t be followed by everyone else.

For example, we’ve been told to eat our greens and that greens and nuts are “anti-inflammatory,” but this is actually not always true. Spinach, bran, rhubarb, beets, nuts, and nut butters all contain oxalate. We now know that oxalate-containing food can be harmful, unless you have the microbes present that can metabolize it into a non-harmful substance.

30% of Viome customers do not have the microbes to metabolize oxalates properly. In other words, “healthy foods” like spinach are actually not healthy for these people.

Looks like not everyone should follow Popeye’s food plan.

2. Aren’t foods containing “antioxidants” always good for everyone?
Just like oxalates, polyphenols in foods are usually considered very healthy, but unless you have microbes that utilize specific polyphenols, you may not get full benefit from them. One example is a substance found in these foods called ellagic acid. We can detect if your microbiome is metabolizing ellagic acid and converting it into urolithin A. It is only the urolithin A that has anti-inflammatory and antioxidant effects. Without the microbes to do this conversion you will not benefit from the ellagic acid in foods.

Examples: Walnuts, raspberries, pomegranate, blackberries, pecans, and cranberries all contain ellagic acid.

We have analyzed tens of thousands of people, and only about 50% of the people actually benefit from eating more foods containing ellagic acid.

3. You’re probably eating too much protein (and it may be causing inflammation).
When you think high-protein diet, you think paleo, keto, and high-performance diets.

Protein is considered good for you. It helps build muscle and provide energy—but if you eat too much, it can cause inflammation and decrease longevity.

We can analyze the activity of your microbiome to determine if you are eating too much protein that feeds protein-fermenting bacteria like Alistipes putredinis and Tannerella forsythia, and if these organisms are producing harmful substances such as ammonia, hydrogen sulfide, p-cresol, or putrescine. These substances can damage your gut lining and lead to things like leaky gut.

4. Something’s fishy. Are “healthy foods” causing heart disease?
Choline in certain foods can get converted by bacteria into a substance called trimethylamine (TMA) that is associated with heart disease when it gets absorbed into your body and converted to TMAO. However, TMA conversion doesn’t happen in individuals without these types of bacteria in their microbiome.

We can see the TMA production pathways and many of the gammaproteobacteria that do this conversion.

What foods contain choline? Liver, salmon, chickpeas, split peas, eggs, navy beans, peanuts, and many others.

Before you decide to go full-on pescatarian or paleo, you may want to check if your microbiome is producing TMA with that salmon or steak.

5. Hold up, Iron Man. We can see inflammation from too much iron.
Minerals like iron in your food can, in certain inflammatory microbial environments, promote growth of pathogens like Esherichia, Shigella, and Salmonella.

Maybe it wasn’t just that raw chicken that gave you food poisoning, but your toxic microbiome that made you sick.

On the other hand, when you don’t have enough iron, you could become anemic leading to weakness and shortness of breath.

So, just like Iron Man, it’s about finding your balance so that you can fly.

6. Are you anxious or stressed? Your poop will tell you.
Our gut and brain are connected via the vagus nerve. A large majority of neurotransmitters are either produced or consumed by our microbiome. In fact, some 90% of all serotonin (a feel-good neurotransmitter) is produced by your gut microbiome and not by your brain.

When you have a toxic microbiome that’s producing a large amount of toxins like hydrogen sulfide, the lining of your gut starts to deteriorate into what’s known as leaky gut. Think of leaky gut as your gut not having healthy borders or boundaries. And when this happens, all kinds of disease can emerge. When the barrier of the gut breaks down, it starts a chain reaction causing low-grade chronic inflammation—which has been identified as a potential source of depression and higher levels of anxiety, in addition to many other chronic diseases.

We’re not saying you shouldn’t meditate, but if you want to get the most out of your meditation and really reduce your stress levels, make sure you are eating the right food that promotes a healthy microbiome.

7. Your microbiome is better than Red Bull.
If you want more energy, get your microbiome back into balance.

No you don’t need three pots of coffee to keep you going, you just need a balanced microbiome.

Your microbiome is responsible for calorie extraction, or creating energy, through pathways such as the Tricarboxylic acid cycle. Our bodies depend on the energy that our microbiome produces.

How much energy we get from our food is dependent on how efficient our microbiome is at converting the food into energy. High-performing microbiomes are excellent at converting food into energy. This is great when you are an athlete and need the extra energy, but if you don’t use up the energy it may be the source of some of those unwanted pounds.

If the microbes can’t or won’t metabolize the glucose (sugar) that you eat, it will be stored as fat. If the microbes are extracting too many calories from your food or producing lipopolysaccharides (LPS) and causing metabolic endotoxemia leading to activation of toll-like receptors and insulin resistance you may end up storing what you eat as fat.

Think of your microbiome as Doc Brown’s car from the future—it can take pretty much anything and turn it into fuel if it’s strong and resilient enough.

8. We can see your joint pain in your poop.
Got joint pain? Your microbiome can tell you why.

Lipopolysaccharide (LPS) is a key pro-inflammatory molecule made by some of your microbes. If your microbes are making too much LPS, it can wreak havoc on your immune system by putting it into overdrive. When your immune system goes on the warpath there is often collateral damage to your joints and other body parts.

Perhaps balancing your microbiome is a better solution than reaching for the glucosamine. Think of your microbiome as the top general of your immune army. It puts your immune system through basic training and determines when it goes to war.

Ideally, your immune system wins the quick battle and gets some rest, but sometimes if your microbiome keeps it on constant high alert it becomes a long, drawn-out war resulting in chronic inflammation and chronic diseases.

Are you really “getting older” or is your microbiome just making you “feel” older because it keeps giving warnings to your immune system ultimately leading to chronic pain?

Before you throw in the towel on your favorite activities, check your microbiome. And, if you have anything with “itis” in it, it’s possible that when you balance your microbiome the inflammation from your “itis” will be reduced.

9. Your gut is doing the talking for your mouth.
When you have low stomach acid, your mouth bacteria makes it down to your GI tract.

Stomach acid is there to protect you from the bacteria in your mouth and the parasites and fungi that are in your food. If you don’t have enough of it, the bacteria in your mouth will invade your gut. This invasion is associated with and a risk factor for autoimmune disease and inflammation in the gut.

We are learning that low stomach acid is perhaps one of the major causes of chronic disease. This stomach acid is essential to kill mouth bacteria and help us digest our food.

What kinds of things cause low stomach acid? Stress and antacids like Nexium, Zantac, and Prilosec.

10. Carbs can be protein precursors.
Rejoice! Perhaps carbs aren’t as bad as we thought (as long as your microbiome is up to the task). We can see if some of the starches you eat can be made into amino acids by the microbiome.

Our microbiome makes 20% of our branched-chain amino acids (BCAAs) for us, and it will adapt to make these vital BCAAs for us in almost any way it can.

Essentially, your microbiome is hooking up carbons and hydrogens into different formulations of BCAAs, depending on what you feed it. The microbiome is excellent at adapting and pivoting based on the food you feed it and the environment that it’s in.

So, good news: Carbs are protein precursors, as long as you have the right microbiome.

Stop Talking Sh*t Now
Your microbiome is a world class entrepreneur that can take low-grade sources of food and turn them into valuable and useable energy.

You have a best friend and confidant within you that is working wonders to make sure you have energy and that all of your needs are met.

And, just like a best friend, if you take great care of your microbiome, it will take great care of you.

Given the research emerging daily about the microbiome and its importance on your quality of life, prioritizing the health of your microbiome is essential.

When you have a healthy microbiome, you’ll have a healthy life.

It’s now clear that some of the greatest insights for your health will come from your poop.

It’s time to stop talking sh*t and get your sh*t together. Your life may depend on it.

Viome can help you identify what your microbiome is actually doing. The combination of Viome’s metatranscriptomic technology and cutting-edge artificial intelligence is paving a brand new path forward for microbiome health.

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Posted in Human Robots

#432482 This Week’s Awesome Stories From ...

CYBERNETICS
A Brain-Boosting Prosthesis Moves From Rats to Humans
Robbie Gonzalez | WIRED
“Today, their proof-of-concept prosthetic lives outside a patient’s head and connects to the brain via wires. But in the future, Hampson hopes, surgeons could implant a similar apparatus entirely within a person’s skull, like a neural pacemaker. It could augment all manner of brain functions—not just in victims of dementia and brain injury, but healthy individuals, as well.”

ARTIFICIAL INTELLIGENCE
Here’s How the US Needs to Prepare for the Age of Artificial Intelligence
Will Knight | MIT Technology Review
“The Trump administration has abandoned this vision and has no intention of devising its own AI plan, say those working there. They say there is no need for an AI moonshot, and that minimizing government interference is the best way to make sure the technology flourishes… That looks like a huge mistake. If it essentially ignores such a technological transformation, the US might never make the most of an opportunity to reboot its economy and kick-start both wage growth and job creation. Failure to plan could also cause the birthplace of AI to lose ground to international rivals.”

BIOMIMICRY
Underwater GPS Inspired by Shrimp Eyes
Jeremy Hsu | IEEE Spectrum
“A few years ago, U.S. and Australian researchers developed a special camera inspired by the eyes of mantis shrimp that can see the polarization patterns of light waves, which resemble those in a rope being waved up and down. That means the bio-inspired camera can detect how light polarization patterns change once the light enters the water and gets deflected or scattered.”

POLITICS & TECHNOLOGY
‘The Business of War’: Google Employees Protest Work for the Pentagon
Scott Shane and Daisuke Wakabayashi | The New York Times
“Thousands of Google employees, including dozens of senior engineers, have signed a letter protesting the company’s involvement in a Pentagon program that uses artificial intelligence to interpret video imagery and could be used to improve the targeting of drone strikes.

The letter, which is circulating inside Google and has garnered more than 3,100 signatures, reflects a culture clash between Silicon Valley and the federal government that is likely to intensify as cutting-edge artificial intelligence is increasingly employed for military purposes. ‘We believe that Google should not be in the business of war,’ says the letter, addressed to Sundar Pichai, the company’s chief executive. It asks that Google pull out of Project Maven, a Pentagon pilot program, and announce a policy that it will not ‘ever build warfare technology.’ (Read the text of the letter.)”

CYBERNETICS
MIT’s New Headset Reads the ‘Words in Your Head’
Brian Heater | TechCrunch
“A team at MIT has been working on just such a device, though the hardware design, admittedly, doesn’t go too far toward removing that whole self-consciousness bit from the equation. AlterEgo is a headmounted—or, more properly, jaw-mounted—device that’s capable of reading neuromuscular signals through built-in electrodes. The hardware, as MIT puts it, is capable of reading ‘words in your head.’”



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#432027 We Read This 800-Page Report on the ...

The longevity field is bustling but still fragmented, and the “silver tsunami” is coming.

That is the takeaway of The Science of Longevity, the behemoth first volume of a four-part series offering a bird’s-eye view of the longevity industry in 2017. The report, a joint production of the Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International, synthesizes the growing array of academic and industry ventures related to aging, healthspan, and everything in between.

This is huge, not only in scale but also in ambition. The report, totally worth a read here, will be followed by four additional volumes in 2018, covering topics ranging from the business side of longevity ventures to financial systems to potential tensions between life extension and religion.

And that’s just the first step. The team hopes to publish updated versions of the report annually, giving scientists, investors, and regulatory agencies an easy way to keep their finger on the longevity pulse.

“In 2018, ‘aging’ remains an unnamed adversary in an undeclared war. For all intents and purposes it is mere abstraction in the eyes of regulatory authorities worldwide,” the authors write.

That needs to change.

People often arrive at the field of aging from disparate areas with wildly diverse opinions and strengths. The report compiles these individual efforts at cracking aging into a systematic resource—a “periodic table” for longevity that clearly lays out emerging trends and promising interventions.

The ultimate goal? A global framework serving as a road map to guide the burgeoning industry. With such a framework in hand, academics and industry alike are finally poised to petition the kind of large-scale investments and regulatory changes needed to tackle aging with a unified front.

Infographic depicting many of the key research hubs and non-profits within the field of geroscience.
Image Credit: Longevity.International
The Aging Globe
The global population is rapidly aging. And our medical and social systems aren’t ready to handle this oncoming “silver tsunami.”

Take the medical field. Many age-related diseases such as Alzheimer’s lack effective treatment options. Others, including high blood pressure, stroke, lung or heart problems, require continuous medication and monitoring, placing enormous strain on medical resources.

What’s more, because disease risk rises exponentially with age, medical care for the elderly becomes a game of whack-a-mole: curing any individual disease such as cancer only increases healthy lifespan by two to three years before another one hits.

That’s why in recent years there’s been increasing support for turning the focus to the root of the problem: aging. Rather than tackling individual diseases, geroscience aims to add healthy years to our lifespan—extending “healthspan,” so to speak.

Despite this relative consensus, the field still faces a roadblock. The US FDA does not yet recognize aging as a bona fide disease. Without such a designation, scientists are banned from testing potential interventions for aging in clinical trials (that said, many have used alternate measures such as age-related biomarkers or Alzheimer’s symptoms as a proxy).

Luckily, the FDA’s stance is set to change. The promising anti-aging drug metformin, for example, is already in clinical trials, examining its effect on a variety of age-related symptoms and diseases. This report, and others to follow, may help push progress along.

“It is critical for investors, policymakers, scientists, NGOs, and influential entities to prioritize the amelioration of the geriatric world scenario and recognize aging as a critical matter of global economic security,” the authors say.

Biomedical Gerontology
The causes of aging are complex, stubborn, and not all clear.

But the report lays out two main streams of intervention with already promising results.

The first is to understand the root causes of aging and stop them before damage accumulates. It’s like meddling with cogs and other inner workings of a clock to slow it down, the authors say.

The report lays out several treatments to keep an eye on.

Geroprotective drugs is a big one. Often repurposed from drugs already on the market, these traditional small molecule drugs target a wide variety of metabolic pathways that play a role in aging. Think anti-oxidants, anti-inflammatory, and drugs that mimic caloric restriction, a proven way to extend healthspan in animal models.

More exciting are the emerging technologies. One is nanotechnology. Nanoparticles of carbon, “bucky-balls,” for example, have already been shown to fight viral infections and dangerous ion particles, as well as stimulate the immune system and extend lifespan in mice (though others question the validity of the results).

Blood is another promising, if surprising, fountain of youth: recent studies found that molecules in the blood of the young rejuvenate the heart, brain, and muscles of aged rodents, though many of these findings have yet to be replicated.

Rejuvenation Biotechnology
The second approach is repair and maintenance.

Rather than meddling with inner clockwork, here we force back the hands of a clock to set it back. The main example? Stem cell therapy.

This type of approach would especially benefit the brain, which harbors small, scattered numbers of stem cells that deplete with age. For neurodegenerative diseases like Alzheimer’s, in which neurons progressively die off, stem cell therapy could in theory replace those lost cells and mend those broken circuits.

Once a blue-sky idea, the discovery of induced pluripotent stem cells (iPSCs), where scientists can turn skin and other mature cells back into a stem-like state, hugely propelled the field into near reality. But to date, stem cells haven’t been widely adopted in clinics.

It’s “a toolkit of highly innovative, highly invasive technologies with clinical trials still a great many years off,” the authors say.

But there is a silver lining. The boom in 3D tissue printing offers an alternative approach to stem cells in replacing aging organs. Recent investment from the Methuselah Foundation and other institutions suggests interest remains high despite still being a ways from mainstream use.

A Disruptive Future
“We are finally beginning to see an industry emerge from mankind’s attempts to make sense of the biological chaos,” the authors conclude.

Looking through the trends, they identified several technologies rapidly gaining steam.

One is artificial intelligence, which is already used to bolster drug discovery. Machine learning may also help identify new longevity genes or bring personalized medicine to the clinic based on a patient’s records or biomarkers.

Another is senolytics, a class of drugs that kill off “zombie cells.” Over 10 prospective candidates are already in the pipeline, with some expected to enter the market in less than a decade, the authors say.

Finally, there’s the big gun—gene therapy. The treatment, unlike others mentioned, can directly target the root of any pathology. With a snip (or a swap), genetic tools can turn off damaging genes or switch on ones that promote a youthful profile. It is the most preventative technology at our disposal.

There have already been some success stories in animal models. Using gene therapy, rodents given a boost in telomerase activity, which lengthens the protective caps of DNA strands, live healthier for longer.

“Although it is the prospect farthest from widespread implementation, it may ultimately prove the most influential,” the authors say.

Ultimately, can we stop the silver tsunami before it strikes?

Perhaps not, the authors say. But we do have defenses: the technologies outlined in the report, though still immature, could one day stop the oncoming tidal wave in its tracks.

Now we just have to bring them out of the lab and into the real world. To push the transition along, the team launched Longevity.International, an online meeting ground that unites various stakeholders in the industry.

By providing scientists, entrepreneurs, investors, and policy-makers a platform for learning and discussion, the authors say, we may finally generate enough drive to implement our defenses against aging. The war has begun.

Read the report in full here, and watch out for others coming soon here. The second part of the report profiles 650 (!!!) longevity-focused research hubs, non-profits, scientists, conferences, and literature. It’s an enormously helpful resource—totally worth keeping it in your back pocket for future reference.

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#432009 How Swarm Intelligence Is Making Simple ...

As a group, simple creatures following simple rules can display a surprising amount of complexity, efficiency, and even creativity. Known as swarm intelligence, this trait is found throughout nature, but researchers have recently begun using it to transform various fields such as robotics, data mining, medicine, and blockchains.

Ants, for example, can only perform a limited range of functions, but an ant colony can build bridges, create superhighways of food and information, wage war, and enslave other ant species—all of which are beyond the comprehension of any single ant. Likewise, schools of fish, flocks of birds, beehives, and other species exhibit behavior indicative of planning by a higher intelligence that doesn’t actually exist.

It happens by a process called stigmergy. Simply put, a small change by a group member causes other members to behave differently, leading to a new pattern of behavior.

When an ant finds a food source, it marks the path with pheromones. This attracts other ants to that path, leads them to the food source, and prompts them to mark the same path with more pheromones. Over time, the most efficient route will become the superhighway, as the faster and easier a path is, the more ants will reach the food and the more pheromones will be on the path. Thus, it looks as if a more intelligent being chose the best path, but it emerged from the tiny, simple changes made by individuals.

So what does this mean for humans? Well, a lot. In the past few decades, researchers have developed numerous algorithms and metaheuristics, such as ant colony optimization and particle swarm optimization, and they are rapidly being adopted.

Swarm Robotics
A swarm of robots would work on the same principles as an ant colony: each member has a simple set of rules to follow, leading to self-organization and self-sufficiency.

For example, researchers at Georgia Robotics and InTelligent Systems (GRITS) created a small swarm of simple robots that can spell and play piano. The robots cannot communicate, but based solely on the position of surrounding robots, they are able to use their specially-created algorithm to determine the optimal path to complete their task.

This is also immensely useful for drone swarms.

Last February, Ehang, an aviation company out of China, created a swarm of a thousand drones that not only lit the sky with colorful, intricate displays, but demonstrated the ability to improvise and troubleshoot errors entirely autonomously.

Further, just recently, the University of Cambridge and Koc University unveiled their idea for what they call the Energy Neutral Internet of Drones. Amazingly, this drone swarm would take initiative to share information or energy with other drones that did not receive a communication or are running low on energy.

Militaries all of the world are utilizing this as well.

Last year, the US Department of Defense announced it had successfully tested a swarm of miniature drones that could carry out complex missions cheaper and more efficiently. They claimed, “The micro-drones demonstrated advanced swarm behaviors such as collective decision-making, adaptive formation flying, and self-healing.”

Some experts estimate at least 30 nations are actively developing drone swarms—and even submersible drones—for military missions, including intelligence gathering, missile defense, precision missile strikes, and enhanced communication.

NASA also plans on deploying swarms of tiny spacecraft for space exploration, and the medical community is looking into using swarms of nanobots for precision delivery of drugs, microsurgery, targeting toxins, and biological sensors.

What If Humans Are the Ants?
The strength of any blockchain comes from the size and diversity of the community supporting it. Cryptocurrencies like Bitcoin, Ethereum, and Litecoin are driven by the people using, investing in, and, most importantly, mining them so their blockchains can function. Without an active community, or swarm, their blockchains wither away.

When viewed from a great height, a blockchain performs eerily like an ant colony in that it will naturally find the most efficient way to move vast amounts of information.

Miners compete with each other to perform the complex calculations necessary to add another block, for which the winner is rewarded with the blockchain’s native currency and agreed-upon fees. Of course, the miner with the more powerful computers is more likely to win the reward, thereby empowering the winner’s ability to mine and receive even more rewards. Over time, fewer and fewer miners are going to exist, as the winners are able to more efficiently shoulder more of the workload, in much the same way that ants build superhighways.

Further, a company called Unanimous AI has developed algorithms that allow humans to collectively make predictions. So far, the AI algorithms and their human participants have made some astoundingly accurate predictions, such as the first four winning horses of the Kentucky Derby, the Oscar winners, the Stanley Cup winners, and others. The more people involved in the swarm, the greater their predictive power will be.

To be clear, this is not a prediction based on group consensus. Rather, the swarm of humans uses software to input their opinions in real time, thus making micro-changes to the rest of the swarm and the inputs of other members.

Studies show that swarm intelligence consistently outperforms individuals and crowds working without the algorithms. While this is only the tip of the iceberg, some have suggested swarm intelligence can revolutionize how doctors diagnose a patient or how products are marketed to consumers. It might even be an essential step in truly creating AI.

While swarm intelligence is an essential part of many species’ success, it’s only a matter of time before humans harness its effectiveness as well.

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Posted in Human Robots

#431967 Will the Next Cold War Be Powered by ...

As tensions between the U.S. and Russia escalate, both sides are developing technological capabilities, including artificial intelligence that could be used in conflict. Continue reading

Posted in Human Robots