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#434580 How Genome Sequencing and Senolytics Can ...

The causes of aging are extremely complex and unclear. With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to find practical ways to extend our healthspan.

Here, in Part 2 of a series of blogs on longevity and vitality, I explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

In this blog I’ll cover two classes of emerging technologies:

Genome Sequencing and Editing;
Senolytics, Nutraceuticals & Pharmaceuticals.

Let’s dive in.

Genome Sequencing & Editing
Your genome is the software that runs your body.

A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity to disease, your lifespan, and so on.

Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean.

Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $5,000 in 2012.

Today, the cost of genome sequencing has dropped below $500, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.

This represents one of the most powerful and transformative technology revolutions in healthcare.

When we understand your genome, we’ll be able to understand how to optimize “you.”

We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later blog).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).

CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally-occurring biological system discovered in 1987 called CRISPR/Cas9.

Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.

Here’s how it works:

The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays.
The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions.
If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.

Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome.

A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.

2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers from the University of Chicago recently used CRISPR to genetically engineer cocaine resistance into mice.

Researchers at the University of Texas Southwestern Medical Center used CRISPR to reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs (DMD is the most common fatal genetic disease in children).

With great power comes great responsibility, and moral and ethical dilemmas.

In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera.

Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.

To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells.

Setting aside the significant ethical conversations, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.

Senolytics, Nutraceuticals & Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.

What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely.

These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse.

Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification, to localized inflammatory conditions such as osteoarthritis, to diminished lung function.

Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.

Prominent companies in the field include the following:

Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology and pulmonary disease.
Oisin Biotechnologiesis pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.
SIWA Therapeuticsis working on an immunotherapy approach to the problem of senescent cells.

In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.

Originally extracted from bacteria found on Easter Island, Rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division.

Currently, rapamycin derivatives are widely used as immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.

PureTech Health subsidiary resTORbio (which started 2018 by going public) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.

Results of the drug’s recent clinical trial include:

Decreased incidence of infection
Improved influenza vaccination response
A 30.6 percent decrease in respiratory tract infections

Impressive, to say the least.

Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients.

Researchers have found that Metformin also reduces oxidative stress and inflammation, which otherwise increase as we age.

There is strong evidence that Metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.

Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of Metformin’s protective effect against cancer.

Nutraceuticals and NAD+
Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.

NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.

The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.

These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.

The next blog in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.

We are edging closer to a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?

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Posted in Human Robots

#434492 Black Mirror’s ‘Bandersnatch’ ...

When was the last time you watched a movie where you could control the plot?

Bandersnatch is the first interactive film in the sci fi anthology series Black Mirror. Written by series creator Charlie Brooker and directed by David Slade, the film tells the story of young programmer Stefan Butler, who is adapting a fantasy choose-your-own-adventure novel called Bandersnatch into a video game. Throughout the film, viewers are given the power to influence Butler’s decisions, leading to diverging plots with different endings.

Like many Black Mirror episodes, this film is mind-bending, dark, and thought-provoking. In addition to innovating cinema as we know it, it is a fascinating rumination on free will, parallel realities, and emerging technologies.

Pick Your Own Adventure
With a non-linear script, Bandersnatch is a viewing experience like no other. Throughout the film viewers are given the option of making a decision for the protagonist. In these instances, they have 10 seconds to make a decision until a default decision is made. For example, in the early stage of the plot, Butler is given the choice of accepting or rejecting Tuckersoft’s offer to develop a video game and the viewer gets to decide what he does. The decision then shapes the plot accordingly.

The video game Butler is developing involves moving through a graphical maze of corridors while avoiding a creature called the Pax, and at times making choices through an on-screen instruction (sound familiar?). In other words, it’s a pick-your-own-adventure video game in a pick-your-own-adventure movie.

Many viewers have ended up spending hours exploring all the different branches of the narrative (though the average viewing is 90 minutes). One user on reddit has mapped out an entire flowchart, showing how all the different decisions (and pseudo-decisions) lead to various endings.

However, over time, Butler starts to question his own free will. It’s almost as if he’s beginning to realize that the audience is controlling him. In one branch of the narrative, he is confronted by this reality when the audience indicates to him that he is being controlled in a Netflix show: “I am watching you on Netflix. I make all the decisions for you”. Butler, as you can imagine, is horrified by this message.

But Butler isn’t the only one who has an illusion of choice. We, the seemingly powerful viewers, also appear to operate under the illusion of choice. Despite there being five main endings to the film, they are all more or less the same.

The Science Behind Bandersnatch
The premise of Bandersnatch isn’t based on fantasy, but hard science. Free will has always been a widely-debated issue in neuroscience, with reputable scientists and studies demonstrating that the whole concept may be an illusion.

In the 1970s, a psychologist named Benjamin Libet conducted a series of experiments that studied voluntary decision making in humans. He found that brain activity imitating an action, such as moving your wrist, preceded the conscious awareness of the action.

Psychologist Malcom Gladwell theorizes that while we like to believe we spend a lot of time thinking about our decisions, our mental processes actually work rapidly, automatically, and often subconsciously, from relatively little information. In addition to this, thinking and making decisions are usually a byproduct of several different brain systems, such as the hippocampus, amygdala, and prefrontal cortex working together. You are more conscious of some information processes in the brain than others.

As neuroscientist and philosopher Sam Harris points out in his book Free Will, “You did not pick your parents or the time and place of your birth. You didn’t choose your gender or most of your life experiences. You had no control whatsoever over your genome or the development of your brain. And now your brain is making choices on the basis of preferences and beliefs that have been hammered into it over a lifetime.” Like Butler, we may believe we are operating under full agency of our abilities, but we are at the mercy of many internal and external factors that influence our decisions.

Beyond free will, Bandersnatch also taps into the theory of parallel universes, a facet of the astronomical theory of the multiverse. In astrophysics, there is a theory that there are parallel universes other than our own, where all the choices you made are played out in alternate realities. For instance, if today you had the option of having cereal or eggs for breakfast, and you chose eggs, in a parallel universe, you chose cereal. Human history and our lives may have taken different paths in these parallel universes.

The Future of Cinema
In the future, the viewing experience will no longer be a passive one. Bandersnatch is just a glimpse into how technology is revolutionizing film as we know it and making it a more interactive and personalized experience. All the different scenarios and branches of the plot were scripted and filmed, but in the future, they may be adapted real-time via artificial intelligence.

Virtual reality may allow us to play an even more active role by making us participants or characters in the film. Data from your history of preferences and may be used to create a unique version of the plot that is optimized for your viewing experience.

Let’s also not underestimate the social purpose of advancing film and entertainment. Science fiction gives us the ability to create simulations of the future. Different narratives can allow us to explore how powerful technologies combined with human behavior can result in positive or negative scenarios. Perhaps in the future, science fiction will explore implications of technologies and observe human decision making in novel contexts, via AI-powered films in the virtual world.

Image Credit: andrey_l / Shutterstock.com

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Posted in Human Robots

#434336 These Smart Seafaring Robots Have a ...

Drones. Self-driving cars. Flying robo taxis. If the headlines of the last few years are to be believed, terrestrial transportation in the future will someday be filled with robotic conveyances and contraptions that will require little input from a human other than to download an app.

But what about the other 70 percent of the planet’s surface—the part that’s made up of water?

Sure, there are underwater drones that can capture 4K video for the next BBC documentary. Remotely operated vehicles (ROVs) are capable of diving down thousands of meters to investigate ocean vents or repair industrial infrastructure.

Yet most of the robots on or below the water today still lean heavily on the human element to operate. That’s not surprising given the unstructured environment of the seas and the poor communication capabilities for anything moving below the waves. Autonomous underwater vehicles (AUVs) are probably the closest thing today to smart cars in the ocean, but they generally follow pre-programmed instructions.

A new generation of seafaring robots—leveraging artificial intelligence, machine vision, and advanced sensors, among other technologies—are beginning to plunge into the ocean depths. Here are some of the latest and most exciting ones.

The Transformer of the Sea
Nic Radford, chief technology officer of Houston Mechatronics Inc. (HMI), is hesitant about throwing around the word “autonomy” when talking about his startup’s star creation, Aquanaut. He prefers the term “shared control.”

Whatever you want to call it, Aquanaut seems like something out of the script of a Transformers movie. The underwater robot begins each mission in a submarine-like shape, capable of autonomously traveling up to 200 kilometers on battery power, depending on the assignment.

When Aquanaut reaches its destination—oil and gas is the primary industry HMI hopes to disrupt to start—its four specially-designed and built linear actuators go to work. Aquanaut then unfolds into a robot with a head, upper torso, and two manipulator arms, all while maintaining proper buoyancy to get its job done.

The lightbulb moment of how to engineer this transformation from submarine to robot came one day while Aquanaut’s engineers were watching the office’s stand-up desks bob up and down. The answer to the engineering challenge of the hull suddenly seemed obvious.

“We’re just gonna build a big, gigantic, underwater stand-up desk,” Radford told Singularity Hub.

Hardware wasn’t the only problem the team, comprised of veteran NASA roboticists like Radford, had to solve. In order to ditch the expensive support vessels and large teams of humans required to operate traditional ROVs, Aquanaut would have to be able to sense its environment in great detail and relay that information back to headquarters using an underwater acoustics communications system that harkens back to the days of dial-up internet connections.

To tackle that problem of low bandwidth, HMI equipped Aquanaut with a machine vision system comprised of acoustic, optical, and laser-based sensors. All of that dense data is compressed using in-house designed technology and transmitted to a single human operator who controls Aquanaut with a few clicks of a mouse. In other words, no joystick required.

“I don’t know of anyone trying to do this level of autonomy as it relates to interacting with the environment,” Radford said.

HMI got $20 million earlier this year in Series B funding co-led by Transocean, one of the world’s largest offshore drilling contractors. That should be enough money to finish the Aquanaut prototype, which Radford said is about 99.8 percent complete. Some “high-profile” demonstrations are planned for early next year, with commercial deployments as early as 2020.

“What just gives us an incredible advantage here is that we have been born and bred on doing robotic systems for remote locations,” Radford noted. “This is my life, and I’ve bet the farm on it, and it takes this kind of fortitude and passion to see these things through, because these are not easy problems to solve.”

On Cruise Control
Meanwhile, a Boston-based startup is trying to solve the problem of making ships at sea autonomous. Sea Machines is backed by about $12.5 million in capital venture funding, with Toyota AI joining the list of investors in a $10 million Series A earlier this month.

Sea Machines is looking to the self-driving industry for inspiration, developing what it calls “vessel intelligence” systems that can be retrofitted on existing commercial vessels or installed on newly-built working ships.

For instance, the startup announced a deal earlier this year with Maersk, the world’s largest container shipping company, to deploy a system of artificial intelligence, computer vision, and LiDAR on the Danish company’s new ice-class container ship. The technology works similar to advanced driver-assistance systems found in automobiles to avoid hazards. The proof of concept will lay the foundation for a future autonomous collision avoidance system.

It’s not just startups making a splash in autonomous shipping. Radford noted that Rolls Royce—yes, that Rolls Royce—is leading the way in the development of autonomous ships. Its Intelligence Awareness system pulls in nearly every type of hyped technology on the market today: neural networks, augmented reality, virtual reality, and LiDAR.

In augmented reality mode, for example, a live feed video from the ship’s sensors can detect both static and moving objects, overlaying the scene with details about the types of vessels in the area, as well as their distance, heading, and other pertinent data.

While safety is a primary motivation for vessel automation—more than 1,100 ships have been lost over the past decade—these new technologies could make ships more efficient and less expensive to operate, according to a story in Wired about the Rolls Royce Intelligence Awareness system.

Sea Hunt Meets Science
As Singularity Hub noted in a previous article, ocean robots can also play a critical role in saving the seas from environmental threats. One poster child that has emerged—or, invaded—is the spindly lionfish.

A venomous critter endemic to the Indo-Pacific region, the lionfish is now found up and down the east coast of North America and beyond. And it is voracious, eating up to 30 times its own stomach volume and reducing juvenile reef fish populations by nearly 90 percent in as little as five weeks, according to the Ocean Support Foundation.

That has made the colorful but deadly fish Public Enemy No. 1 for many marine conservationists. Both researchers and startups are developing autonomous robots to hunt down the invasive predator.

At the Worcester Polytechnic Institute, for example, students are building a spear-carrying robot that uses machine learning and computer vision to distinguish lionfish from other aquatic species. The students trained the algorithms on thousands of different images of lionfish. The result: a lionfish-killing machine that boasts an accuracy of greater than 95 percent.

Meanwhile, a small startup called the American Marine Research Corporation out of Pensacola, Florida is applying similar technology to seek and destroy lionfish. Rather than spearfishing, the AMRC drone would stun and capture the lionfish, turning a profit by selling the creatures to local seafood restaurants.

Lionfish: It’s what’s for dinner.

Water Bots
A new wave of smart, independent robots are diving, swimming, and cruising across the ocean and its deepest depths. These autonomous systems aren’t necessarily designed to replace humans, but to venture where we can’t go or to improve safety at sea. And, perhaps, these latest innovations may inspire the robots that will someday plumb the depths of watery planets far from Earth.

Image Credit: Houston Mechatronics, Inc. Continue reading

Posted in Human Robots

#434324 Big Brother Nation: The Case for ...

Powerful surveillance cameras have crept into public spaces. We are filmed and photographed hundreds of times a day. To further raise the stakes, the resulting video footage is fed to new forms of artificial intelligence software that can recognize faces in real time, read license plates, even instantly detect when a particular pre-defined action or activity takes place in front of a camera.

As most modern cities have quietly become surveillance cities, the law has been slow to catch up. While we wait for robust legal frameworks to emerge, the best way to protect our civil liberties right now is to fight technology with technology. All cities should place local surveillance video into a public cloud-based data trust. Here’s how it would work.

In Public Data We Trust
To democratize surveillance, every city should implement three simple rules. First, anyone who aims a camera at public space must upload that day’s haul of raw video file (and associated camera meta-data) into a cloud-based repository. Second, this cloud-based repository must have open APIs and a publicly-accessible log file that records search histories and tracks who has accessed which video files. And third, everyone in the city should be given the same level of access rights to the stored video data—no exceptions.

This kind of public data repository is called a “data trust.” Public data trusts are not just wishful thinking. Different types of trusts are already in successful use in Estonia and Barcelona, and have been proposed as the best way to store and manage the urban data that will be generated by Alphabet’s planned Sidewalk Labs project in Toronto.

It’s true that few people relish the thought of public video footage of themselves being looked at by strangers and friends, by ex-spouses, potential employers, divorce attorneys, and future romantic prospects. In fact, when I propose this notion when I give talks about smart cities, most people recoil in horror. Some turn red in the face and jeer at my naiveté. Others merely blink quietly in consternation.

The reason we should take this giant step towards extreme transparency is to combat the secrecy that surrounds surveillance. Openness is a powerful antidote to oppression. Edward Snowden summed it up well when he said, “Surveillance is not about public safety, it’s about power. It’s about control.”

Let Us Watch Those Watching Us
If public surveillance video were put back into the hands of the people, citizens could watch their government as it watches them. Right now, government cameras are controlled by the state. Camera locations are kept secret, and only the agencies that control the cameras get to see the footage they generate.

Because of these information asymmetries, civilians have no insight into the size and shape of the modern urban surveillance infrastructure that surrounds us, nor the uses (or abuses) of the video footage it spawns. For example, there is no swift and efficient mechanism to request a copy of video footage from the cameras that dot our downtown. Nor can we ask our city’s police force to show us a map that documents local traffic camera locations.

By exposing all public surveillance videos to the public gaze, cities could give regular people tools to assess the size, shape, and density of their local surveillance infrastructure and neighborhood “digital dragnet.” Using the meta-data that’s wrapped around video footage, citizens could geo-locate individual cameras onto a digital map to generate surveillance “heat maps.” This way people could assess whether their city’s camera density was higher in certain zip codes, or in neighborhoods populated by a dominant ethnic group.

Surveillance heat maps could be used to document which government agencies were refusing to upload their video files, or which neighborhoods were not under surveillance. Given what we already know today about the correlation between camera density, income, and social status, these “dark” camera-free regions would likely be those located near government agencies and in more affluent parts of a city.

Extreme transparency would democratize surveillance. Every city’s data trust would keep a publicly-accessible log of who’s searching for what, and whom. People could use their local data trust’s search history to check whether anyone was searching for their name, face, or license plate. As a result, clandestine spying on—and stalking of—particular individuals would become difficult to hide and simpler to prove.

Protect the Vulnerable and Exonerate the Falsely Accused
Not all surveillance video automatically works against the underdog. As the bungled (and consequently no longer secret) assassination of journalist Jamal Khashoggi demonstrated, one of the unexpected upsides of surveillance cameras has been the fact that even kings become accountable for their crimes. If opened up to the public, surveillance cameras could serve as witnesses to justice.

Video evidence has the power to protect vulnerable individuals and social groups by shedding light onto messy, unreliable (and frequently conflicting) human narratives of who did what to whom, and why. With access to a data trust, a person falsely accused of a crime could prove their innocence. By searching for their own face in video footage or downloading time/date stamped footage from a particular camera, a potential suspect could document their physical absence from the scene of a crime—no lengthy police investigation or high-priced attorney needed.

Given Enough Eyeballs, All Crimes Are Shallow
Placing public surveillance video into a public trust could make cities safer and would streamline routine police work. Linus Torvalds, the developer of open-source operating system Linux, famously observed that “given enough eyeballs, all bugs are shallow.” In the case of public cameras and a common data repository, Torvald’s Law could be restated as “given enough eyeballs, all crimes are shallow.”

If thousands of citizen eyeballs were given access to a city’s public surveillance videos, local police forces could crowdsource the work of solving crimes and searching for missing persons. Unfortunately, at the present time, cities are unable to wring any social benefit from video footage of public spaces. The most formidable barrier is not government-imposed secrecy, but the fact that as cameras and computers have grown cheaper, a large and fast-growing “mom and pop” surveillance state has taken over most of the filming of public spaces.

While we fear spooky government surveillance, the reality is that we’re much more likely to be filmed by security cameras owned by shopkeepers, landlords, medical offices, hotels, homeowners, and schools. These businesses, organizations, and individuals install cameras in public areas for practical reasons—to reduce their insurance costs, to prevent lawsuits, or to combat shoplifting. In the absence of regulations governing their use, private camera owners store video footage in a wide variety of locations, for varying retention periods.

The unfortunate (and unintended) result of this informal and decentralized network of public surveillance is that video files are not easy to access, even for police officers on official business. After a crime or terrorist attack occurs, local police (or attorneys armed with a subpoena) go from door to door to manually collect video evidence. Once they have the videos in hand, their next challenge is searching for the right “codex” to crack the dozens of different file formats they encounter so they can watch and analyze the footage.

The result of these practical barriers is that as it stands today, only people with considerable legal or political clout are able to successfully gain access into a city’s privately-owned, ad-hoc collections of public surveillance videos. Not only are cities missing the opportunity to streamline routine evidence-gathering police work, they’re missing a radically transformative benefit that would become possible once video footage from thousands of different security cameras were pooled into a single repository: the ability to apply the power of citizen eyeballs to the work of improving public safety.

Why We Need Extreme Transparency
When regular people can’t access their own surveillance videos, there can be no data justice. While we wait for the law to catch up with the reality of modern urban life, citizens and city governments should use technology to address the problem that lies at the heart of surveillance: a power imbalance between those who control the cameras and those who don’t.

Cities should permit individuals and organizations to install and deploy as many public-facing cameras as they wish, but with the mandate that camera owners must place all resulting video footage into the mercilessly bright sunshine of an open data trust. This way, cloud computing, open APIs, and artificial intelligence software can help combat abuses of surveillance and give citizens insight into who’s filming us, where, and why.

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Posted in Human Robots

#434303 Making Superhumans Through Radical ...

Imagine trying to read War and Peace one letter at a time. The thought alone feels excruciating. But in many ways, this painful idea holds parallels to how human-machine interfaces (HMI) force us to interact with and process data today.

Designed back in the 1970s at Xerox PARC and later refined during the 1980s by Apple, today’s HMI was originally conceived during fundamentally different times, and specifically, before people and machines were generating so much data. Fast forward to 2019, when humans are estimated to produce 44 zettabytes of data—equal to two stacks of books from here to Pluto—and we are still using the same HMI from the 1970s.

These dated interfaces are not equipped to handle today’s exponential rise in data, which has been ushered in by the rapid dematerialization of many physical products into computers and software.

Breakthroughs in perceptual and cognitive computing, especially machine learning algorithms, are enabling technology to process vast volumes of data, and in doing so, they are dramatically amplifying our brain’s abilities. Yet even with these powerful technologies that at times make us feel superhuman, the interfaces are still crippled with poor ergonomics.

Many interfaces are still designed around the concept that human interaction with technology is secondary, not instantaneous. This means that any time someone uses technology, they are inevitably multitasking, because they must simultaneously perform a task and operate the technology.

If our aim, however, is to create technology that truly extends and amplifies our mental abilities so that we can offload important tasks, the technology that helps us must not also overwhelm us in the process. We must reimagine interfaces to work in coherence with how our minds function in the world so that our brains and these tools can work together seamlessly.

Embodied Cognition
Most technology is designed to serve either the mind or the body. It is a problematic divide, because our brains use our entire body to process the world around us. Said differently, our minds and bodies do not operate distinctly. Our minds are embodied.

Studies using MRI scans have shown that when a person feels an emotion in their gut, blood actually moves to that area of the body. The body and the mind are linked in this way, sharing information back and forth continuously.

Current technology presents data to the brain differently from how the brain processes data. Our brains, for example, use sensory data to continually encode and decipher patterns within the neocortex. Our brains do not create a linguistic label for each item, which is how the majority of machine learning systems operate, nor do our brains have an image associated with each of these labels.

Our bodies move information through us instantaneously, in a sense “computing” at the speed of thought. What if our technology could do the same?

Using Cognitive Ergonomics to Design Better Interfaces
Well-designed physical tools, as philosopher Martin Heidegger once meditated on while using the metaphor of a hammer, seem to disappear into the “hand.” They are designed to amplify a human ability and not get in the way during the process.

The aim of physical ergonomics is to understand the mechanical movement of the human body and then adapt a physical system to amplify the human output in accordance. By understanding the movement of the body, physical ergonomics enables ergonomically sound physical affordances—or conditions—so that the mechanical movement of the body and the mechanical movement of the machine can work together harmoniously.

Cognitive ergonomics applied to HMI design uses this same idea of amplifying output, but rather than focusing on physical output, the focus is on mental output. By understanding the raw materials the brain uses to comprehend information and form an output, cognitive ergonomics allows technologists and designers to create technological affordances so that the brain can work seamlessly with interfaces and remove the interruption costs of our current devices. In doing so, the technology itself “disappears,” and a person’s interaction with technology becomes fluid and primary.

By leveraging cognitive ergonomics in HMI design, we can create a generation of interfaces that can process and present data the same way humans process real-world information, meaning through fully-sensory interfaces.

Several brain-machine interfaces are already on the path to achieving this. AlterEgo, a wearable device developed by MIT researchers, uses electrodes to detect and understand nonverbal prompts, which enables the device to read the user’s mind and act as an extension of the user’s cognition.

Another notable example is the BrainGate neural device, created by researchers at Stanford University. Just two months ago, a study was released showing that this brain implant system allowed paralyzed patients to navigate an Android tablet with their thoughts alone.

These are two extraordinary examples of what is possible for the future of HMI, but there is still a long way to go to bring cognitive ergonomics front and center in interface design.

Disruptive Innovation Happens When You Step Outside Your Existing Users
Most of today’s interfaces are designed by a narrow population, made up predominantly of white, non-disabled men who are prolific in the use of technology (you may recall The New York Times viral article from 2016, Artificial Intelligence’s White Guy Problem). If you ask this population if there is a problem with today’s HMIs, most will say no, and this is because the technology has been designed to serve them.

This lack of diversity means a limited perspective is being brought to interface design, which is problematic if we want HMI to evolve and work seamlessly with the brain. To use cognitive ergonomics in interface design, we must first gain a more holistic understanding of how people with different abilities understand the world and how they interact with technology.

Underserved groups, such as people with physical disabilities, operate on what Clayton Christensen coined in The Innovator’s Dilemma as the fringe segment of a market. Developing solutions that cater to fringe groups can in fact disrupt the larger market by opening a downward, much larger market.

Learning From Underserved Populations
When technology fails to serve a group of people, that group must adapt the technology to meet their needs.

The workarounds created are often ingenious, specifically because they have not been arrived at by preferences, but out of necessity that has forced disadvantaged users to approach the technology from a very different vantage point.

When a designer or technologist begins learning from this new viewpoint and understanding challenges through a different lens, they can bring new perspectives to design—perspectives that otherwise can go unseen.

Designers and technologists can also learn from people with physical disabilities who interact with the world by leveraging other senses that help them compensate for one they may lack. For example, some blind people use echolocation to detect objects in their environments.

The BrainPort device developed by Wicab is an incredible example of technology leveraging one human sense to serve or compliment another. The BrainPort device captures environmental information with a wearable video camera and converts this data into soft electrical stimulation sequences that are sent to a device on the user’s tongue—the most sensitive touch receptor in the body. The user learns how to interpret the patterns felt on their tongue, and in doing so, become able to “see” with their tongue.

Key to the future of HMI design is learning how different user groups navigate the world through senses beyond sight. To make cognitive ergonomics work, we must understand how to leverage the senses so we’re not always solely relying on our visual or verbal interactions.

Radical Inclusion for the Future of HMI
Bringing radical inclusion into HMI design is about gaining a broader lens on technology design at large, so that technology can serve everyone better.

Interestingly, cognitive ergonomics and radical inclusion go hand in hand. We can’t design our interfaces with cognitive ergonomics without bringing radical inclusion into the picture, and we also will not arrive at radical inclusion in technology so long as cognitive ergonomics are not considered.

This new mindset is the only way to usher in an era of technology design that amplifies the collective human ability to create a more inclusive future for all.

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