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#436100 Labrador Systems Developing Affordable ...

Developing robots for the home is still a challenge, especially if you want those robots to interact with people and help them do practical, useful things. However, the potential markets for home robots are huge, and one of the most compelling markets is for home robots that can assist humans who need them. Today, Labrador Systems, a startup based in California, is announcing a pre-seed funding round of $2 million (led by SOSV’s hardware accelerator HAX with participation from Amazon’s Alexa Fund and iRobot Ventures, among others) with the goal of expanding development and conducting pilot studies of “a new [assistive robot] platform for supporting home health.”

Labrador was founded two years ago by Mike Dooley and Nikolai Romanov. Both Mike and Nikolai have backgrounds in consumer robotics at Evolution Robotics and iRobot, but as an ’80s gamer, Mike’s bio (or at least the parts of his bio on LinkedIn) caught my attention: From 1995 to 1997, Mike worked at Brøderbund Software, helping to manage play testing for games like Myst and Riven and the Where in the World is Carmen San Diego series. He then spent three years at Lego as the product manager for MindStorms. After doing some marginally less interesting things, Mike was the VP of product development at Evolution Robotics from 2006 to 2012, where he led the team that developed the Mint floor sweeping robot. Evolution was acquired by iRobot in 2012, and Mike ended up as the VP of product development over there until 2017, when he co-founded Labrador.

I was pretty much sold at Where in the World is Carmen San Diego (the original version of which I played from a 5.25” floppy on my dad’s Apple IIe)*, but as you can see from all that other stuff, Mike knows what he’s doing in robotics as well.

And according to Labrador’s press release, what they’re doing is this:

Labrador Systems is an early stage technology company developing a new generation of assistive robots to help people live more independently. The company’s core focus is creating affordable solutions that address practical and physical needs at a fraction of the cost of commercial robots. … Labrador’s technology platform offers an affordable solution to improve the quality of care while promoting independence and successful aging.

Labrador’s personal robot, the company’s first offering, will enter pilot studies in 2020.

That’s about as light on detail as a press release gets, but there’s a bit more on Labrador’s website, including:

Our core focus is creating affordable solutions that address practical and physical needs. (we are not a social robot company)
By affordable, we mean products and technologies that will be available at less than 1/10th the cost of commercial robots.
We achieve those low costs by fusing the latest technologies coming out of augmented reality with robotics to move things in the real world.

The only hardware we’ve actually seen from Labrador at this point is a demo that they put together for Amazon’s re:MARS conference, which took place a few months ago, showing a “demonstration project” called Smart Walker:

This isn’t the home assistance robot that Labrador got its funding for, but rather a demonstration of some of their technology. So of course, the question is, what’s Labrador working on, then? It’s still a secret, but Mike Dooley was able to give us a few more details.

IEEE Spectrum: Your website shows a smart walker concept—how is that related to the assistive robot that you’re working on?

Mike Dooley: The smart walker was a request from a major senior living organization to have our robot (which is really good at navigation) guide residents from place to place within their communities. To test the idea with residents, it turned out to be much quicker to take the navigation system from the robot and put it on an existing rollator walker. So when you see the clips of the technology in the smart walker video on our website, that’s actually the robot’s navigation system localizing in real time and path planning in an environment.

“Assistive robot” can cover a huge range of designs and capabilities—can you give us any more detail about your robot, and what it’ll be able to do?

One of the core features of our robot is to help people move things where they have difficulty moving themselves, particularly in the home setting. That may sound trivial, but to someone who has impaired mobility, it can be a major daily challenge and negatively impact their life and health in a number of ways. Some examples we repeatedly hear are people not staying hydrated or taking their medication on time simply because there is a distance between where they are and the items they need. Once we have those base capabilities, i.e. the ability to navigate around a home and move things within it, then the robot becomes a platform for a wider variety of applications.

What made you decide to develop assistive robots, and why are robots a good solution for seniors who want to live independently?

Supporting independent living has been seen as a massive opportunity in robotics for some time, but also as something off in the future. The turning point for me was watching my mother enter that stage in her life and seeing her transition to using a cane, then a walker, and eventually to a wheelchair. That made the problems very real for me. It also made things much clearer about how we could start addressing specific needs with the tools that are becoming available now.

In terms of why robots can be a good solution, the basic answer is the level of need is so overwhelming that even helping with “basic” tasks can make an appreciable difference in the quality of someone’s daily life. It’s also very much about giving individuals a degree of control back over their environment. That applies to seniors as well as others whose world starts getting more complex to manage as their abilities become more impaired.

What are the particular challenges of developing assistive robots, and how are you addressing them? Why do you think there aren’t more robotics startups in this space?

The setting (operating in homes and personal spaces) and the core purpose of the product (aiding a wide variety of individuals) bring a lot of complexity to any capability you want to build into an assistive robot. Our approach is to put as much structure as we can into the system to make it functional, affordable, understandable and reliable.

I think one of the reasons you don’t see more startups in the space is that a lot of roboticists want to skip ahead and do the fancy stuff, such as taking on human-level capabilities around things like manipulation. Those are very interesting research topics, but we think those are also very far away from being practical solutions you can productize for people to use in their homes.

How do you think assistive robots and human caregivers should work together?

The ideal scenario is allowing caregivers to focus more of their time on the high-touch, personal side of care. The robot can offload the more basic support tasks as well as extend the impact of the caregiver for the long hours of the day they can’t be with someone at their home. We see that applying to both paid care providers as well as the 40 million unpaid family members and friends that provide assistance.

The robot is really there as a tool, both for individuals in need and the people that help them. What’s promising in the research discussions we’ve had so far, is that even when a caregiver is present, giving control back to the individual for simple things can mean a lot in the relationship between them and the caregiver.

What should we look forward to from Labrador in 2020?

Our big goal in 2020 is to start placing the next version of the robot with individuals with different types of needs to let them experience it naturally in their own homes and provide feedback on what they like, what don’t like and how we can make it better. We are currently reaching out to companies in the healthcare and home health fields to participate in those studies and test specific applications related to their services. We plan to share more detail about those studies and the robot itself as we get further into 2020.

If you’re an organization (or individual) who wants to possibly try out Labrador’s prototype, the company encourages you to connect with them through their website. And as we learn more about what Labrador is up to, we’ll have updates for you, presumably in 2020.

[ Labrador Systems ]

* I just lost an hour of my life after finding out that you can play Where in the World is Carmen San Diego in your browser for free. Continue reading

Posted in Human Robots

#435742 This ‘Useless’ Social Robot ...

The recent high profile failures of some home social robots (and the companies behind them) have made it even more challenging than it was before to develop robots in that space. And it was challenging enough to begin with—making a robot that can autonomous interact with random humans in their homes over a long period of time for a price that people can afford is extraordinarily difficult. However, the massive amount of initial interest in robots like Jibo, Kuri, Vector, and Buddy prove that people do want these things, or at least think they do, and while that’s the case, there’s incentive for other companies to give social home robots a try.

One of those companies is Zoetic, founded in 2107 by Mita Yun and Jitu Das, both ex-Googlers. Their robot, Kiki, is more or less exactly what you’d expect from a social home robot: It’s cute, white, roundish, has big eyes, promises that it will be your “robot sidekick,” and is not cheap: It’s on Kicksterter for $800. Kiki is among what appears to be a sort of tentative second wave of social home robots, where designers have (presumably) had a chance to take everything that they learned from the social home robot pioneers and use it to make things better this time around.

Kiki’s Kickstarter video is, again, more or less exactly what you’d expect from a social home robot crowdfunding campaign:

We won’t get into all of the details on Kiki in this article (the Kickstarter page has tons of information), but a few distinguishing features:

Each Kiki will develop its own personality over time through its daily interactions with its owner, other people, and other Kikis.
Interacting with Kiki is more abstract than with most robots—it can understand some specific words and phrases, and will occasionally use a few specific words or two, but otherwise it’s mostly listening to your tone of voice and responding with sounds rather than speech.
Kiki doesn’t move on its own, but it can operate for up to two hours away from its charging dock.
Depending on how your treat Kiki, it can get depressed or neurotic. It also needs to be fed, which you can do by drawing different kinds of food in the app.
Everything Kiki does runs on-board the robot. It has Wi-Fi connectivity for updates, but doesn’t rely on the cloud for anything in real-time, meaning that your data stays on the robot and that the robot will continue to function even if its remote service shuts down.

It’s hard to say whether features like these are unique enough to help Kiki be successful where other social home robots haven’t been, so we spoke with Zoetic co-founder Mita Yun and asked her why she believes that Kiki is going to be the social home robot that makes it.

IEEE Spectrum: What’s your background?

Mita Yun: I was an only child growing up, and so I always wanted something like Doraemon or Totoro. Something that when you come home it’s there to greet you, not just because it’s programmed to do that but because it’s actually actively happy to see you, and only you. I was so interested in this that I went to study robotics at CMU and then after I graduated I joined Google and worked there for five years. I tended to go for the more risky and more fun projects, but they always got cancelled—the first project I joined was called Android at Home, and then I joined Google Glass, and then I joined a team called Robots for Kids. That project was building educational robots, and then I just realized that when we’re adding technology to something, to a product, we’re actually taking the life away somehow, and the kids were more connected with stuffed animals compared to the educational robots we were building. That project was also cancelled, and in 2017, I left with a coworker of mine (Jitu Das) to bring this dream into reality. And now we’re building Kiki.

“Jibo was Alexa plus cuteness equals $800, and I feel like that equation doesn’t work for most people, and that eventually killed the company. So, for Kiki, we are actually building something very different. We’re building something that’s completely useless”
—Mita Yun, Zoetic

You started working on Kiki in 2017, when things were already getting challenging for Jibo—why did you decide to start developing a social home robot at that point?

I thought Jibo was great. It had a special magical way of moving, and it was such a new idea that you could have this robot with embodiment and it can actually be your assistant. The problem with Jibo, in my opinion, was that it took too long to fulfill the orders. It took them three to four years to actually manufacture, because it was a very complex piece of hardware, and then during that period of time Alexa and Google Home came out, and they started selling these voice systems for $30 and then you have Jibo for $800. Jibo was Alexa plus cuteness equals $800, and I feel like that equation doesn’t work for most people, and that eventually killed the company. So, for Kiki, we are actually building something very different. We’re building something that’s completely useless.

Can you elaborate on “completely useless?”

I feel like people are initially connected with robots because they remind them of a character. And it’s the closest we can get to a character other than an organic character like an animal. So we’re connected to a character like when we have a robot in a mall that’s roaming around, even if it looks really ugly, like if it doesn’t have eyes, people still take selfies with it. Why? Because they think it’s a character. And humans are just hardwired to love characters and love stories. With Kiki, we just wanted to build a character that’s alive, we don’t want to have a character do anything super useful.

I understand why other robotics companies are adding Alexa integration to their robots, and I think that’s great. But the dream I had, and the understanding I have about robotics technology, is that for a consumer robot especially, it is very very difficult for the robot to justify its price through usefulness. And then there’s also research showing that the more useless something is, the easier it is to have an emotional connection, so that’s why we want to keep Kiki very useless.

What kind of character are you creating with Kiki?

The whole design principle around Kiki is we want to make it a very vulnerable character. In terms of its status at home, it’s not going to be higher or equal status as the owner, but slightly lower status than the human, and it’s vulnerable and needs you to take care of it in order to grow up into a good personality robot.

We don’t let Kiki speak full English sentences, because whenever it does that, people are going to think it’s at least as intelligent as a baby, which is impossible for robots at this point. And we also don’t let it move around, because when you have it move around, people are going to think “I’m going to call Kiki’s name, and then Kiki is will come to me.” But that is actually very difficult to build. And then also we don’t have any voice integration so it doesn’t tell you about the stock market price and so on.

Photo: Zoetic

Kiki is designed to be “vulnerable,” and it needs you to take care of it so it can “grow up into a good personality robot,” according to its creators.

That sounds similar to what Mayfield did with Kuri, emphasizing an emotional connection rather than specific functionality.

It is very similar, but one of the key differences from Kuri, I think, is that Kuri started with a Kobuki base, and then it’s wrapped into a cute shell, and they added sounds. So Kuri started with utility in mind—navigation is an important part of Kuri, so they started with that challenge. For Kiki, we started with the eyes. The entire thing started with the character itself.

How will you be able to convince your customers to spend $800 on a robot that you’ve described as “useless” in some ways?

Because it’s useless, it’s actually easier to convince people, because it provides you with an emotional connection. I think Kiki is not a utility-driven product, so the adoption cycle is different. For a functional product, it’s very easy to pick up, because you can justify it by saying “I’m going to pay this much and then my life can become this much more efficient.” But it’s also very easy to be replaced and forgotten. For an emotional-driven product, it’s slower to pick up, but once people actually pick it up, they’re going to be hooked—they get be connected with it, and they’re willing to invest more into taking care of the robot so it will grow up to be smarter.

Maintaining value over time has been another challenge for social home robots. How will you make sure that people don’t get bored with Kiki after a few weeks?

Of course Kiki has limits in what it can do. We can combine the eyes, the facial expression, the motors, and lights and sounds, but is it going to be constantly entertaining? So we think of this as, imagine if a human is actually puppeteering Kiki—can Kiki stay interesting if a human is puppeteering it and interacting with the owner? So I think what makes a robot interesting is not just in the physical expressions, but the part in between that and the robot conveying its intentions and emotions.

For example, if you come into the room and then Kiki decides it will turn the other direction, ignore you, and then you feel like, huh, why did the robot do that to me? Did I do something wrong? And then maybe you will come up to it and you will try to figure out why it did that. So, even though Kiki can only express in four different dimensions, it can still make things very interesting, and then when its strategies change, it makes it feel like a new experience.

There’s also an explore and exploit process going on. Kiki wants to make you smile, and it will try different things. It could try to chase its tail, and if you smile, Kiki learns that this works and will exploit it. But maybe after doing it three times, you no longer find it funny, because you’re bored of it, and then Kiki will observe your reactions and be motivated to explore a new strategy.

Photo: Zoetic

Kiki’s creators are hoping that, with an emotionally engaging robot, it will be easier for people to get attached to it and willing to spend time taking care of it.

A particular risk with crowdfunding a robot like this is setting expectations unreasonably high. The emphasis on personality and emotional engagement with Kiki seems like it may be very difficult for the robot to live up to in practice.

I think we invested more than most robotics companies into really building out Kiki’s personality, because that is the single most important thing to us. For Jibo a lot of the focus was in the assistant, and for Kuri, it’s more in the movement. For Kiki, it’s very much in the personality.

I feel like when most people talk about personality, they’re mainly talking about expression. With Kiki, it’s not just in the expression itself, not just in the voice or the eyes or the output layer, it’s in the layer in between—when Kiki receives input, how will it make decisions about what to do? We actually don’t think the personality of Kiki is categorizable, which is why I feel like Kiki has a deeper implementation of how personalities should work. And you’re right, Kiki doesn’t really understand why you’re feeling a certain way, it just reads your facial expressions. It’s maybe not your best friend, but maybe closer to your little guinea pig robot.

Photo: Zoetic

The team behind Kiki paid particular attention to its eyes, and designed the robot to always face the person that it is interacting with.

Is that where you’d put Kiki on the scale of human to pet?

Kiki is definitely not human, we want to keep it very far away from human. And it’s also not a dog or cat. When we were designing Kiki, we took inspiration from mammals because humans are deeply connected to mammals since we’re mammals ourselves. And specifically we’re connected to predator animals. With prey animals, their eyes are usually on the sides of their heads, because they need to see different angles. A predator animal needs to hunt, they need to focus. Cats and dogs are predator animals. So with Kiki, that’s why we made sure the eyes are on one side of the face and the head can actuate independently from the body and the body can turn so it’s always facing the person that it’s paying attention to.

I feel like Kiki is probably does more than a plant. It does more than a fish, because a fish doesn’t look you in the eyes. It’s not as smart as a cat or a dog, so I would just put it in this guinea pig kind of category.

What have you found so far when running user studies with Kiki?

When we were first designing Kiki we went through a whole series of prototypes. One of the earlier prototypes of Kiki looked like a CRT, like a very old monitor, and when we were testing that with people they didn’t even want to touch it. Kiki’s design inspiration actually came from an airplane, with a very angular, futuristic look, but based on user feedback we made it more round and more friendly to the touch. The lights were another feature request from the users, which adds another layer of expressivity to Kiki, and they wanted to see multiple Kikis working together with different personalities. Users also wanted different looks for Kiki, to make it look like a deer or a unicorn, for example, and we actually did take that into consideration because it doesn’t look like any particular mammal. In the future, you’ll be able to have different ears to make it look like completely different animals.

There has been a lot of user feedback that we didn’t implement—I believe we should observe the users reactions and feedback but not listen to their advice. The users shouldn’t be our product designers, because if you test Kiki with 10 users, eight of them will tell you they want Alexa in it. But we’re never going to add Alexa integration to Kiki because that’s not what it’s meant to do.

While it’s far too early to tell whether Kiki will be a long-term success, the Kickstarter campaign is currently over 95 percent funded with 8 days to go, and 34 robots are still available for a May 2020 delivery.

[ Kickstarter ] Continue reading

Posted in Human Robots

#435640 Video Friday: This Wearable Robotic Tail ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

DARPA SubT Tunnel Circuit – August 15-22, 2019 – Pittsburgh, Pa., USA
CLAWAR 2019 – August 26-28, 2019 – Kuala Lumpur, Malaysia
IEEE Africon 2019 – September 25-27, 2019 – Accra, Ghana
ISRR 2019 – October 6-10, 2019 – Hanoi, Vietnam
Ro-Man 2019 – October 14-18, 2019 – New Delhi, India
Humanoids 2019 – October 15-17, 2019 – Toronto, Canada
ARSO 2019 – October 31-1, 2019 – Beijing, China
ROSCon 2019 – October 31-1, 2019 – Macau
IROS 2019 – November 4-8, 2019 – Macau
Let us know if you have suggestions for next week, and enjoy today’s videos.

Lakshmi Nair from Georgia Tech describes some fascinating research towards robots that can create their own tools, as presented at ICRA this year:

Using a novel capability to reason about shape, function, and attachment of unrelated parts, researchers have for the first time successfully trained an intelligent agent to create basic tools by combining objects.

The breakthrough comes from Georgia Tech’s Robot Autonomy and Interactive Learning (RAIL) research lab and is a significant step toward enabling intelligent agents to devise more advanced tools that could prove useful in hazardous – and potentially life-threatening – environments.

[ Lakshmi Nair ]

Victor Barasuol, from the Dynamic Legged Systems Lab at IIT, wrote in to share some new research on their HyQ quadruped that enables sensorless shin collision detection. This helps the robot navigate unstructured environments, and also mitigates all those painful shin strikes, because ouch.

This will be presented later this month at the International Conference on Climbing and Walking Robots (CLAWAR) in Kuala Lumpur, Malaysia.

[ IIT ]

Thanks Victor!

You used to have a tail, you know—as an embryo, about a month in to your development. All mammals used to have tails, and now we just have useless tailbones, which don’t help us with balancing even a little bit. BRING BACK THE TAIL!

The tail, created by Junichi Nabeshima, Kouta Minamizawa, and MHD Yamen Saraiji from Keio University’s Graduate School of Media Design, was presented at SIGGRAPH 2019 Emerging Technologies.

[ Paper ] via [ Gizmodo ]

The noises in this video are fantastic.

[ ESA ]

Apparently the industrial revolution wasn’t a thorough enough beatdown of human knitting, because the robots are at it again.

[ MIT CSAIL ]

Skydio’s drones just keep getting more and more impressive. Now if only they’d make one that I can afford…

[ Skydio ]

The only thing more fun than watching robots is watching people react to robots.

[ SEER ]

There aren’t any robots in this video, but it’s robotics-related research, and very soothing to watch.

[ Stanford ]

#autonomousicecreamtricycle

In case it wasn’t clear, which it wasn’t, this is a Roboy project. And if you didn’t understand that first video, you definitely won’t understand this second one:

Whatever that t-shirt is at the end (Roboy in sunglasses puking rainbows…?) I need one.

[ Roboy ]

By adding electronics and computation technology to a simple cane that has been around since ancient times, a team of researchers at Columbia Engineering have transformed it into a 21st century robotic device that can provide light-touch assistance in walking to the aged and others with impaired mobility.

The light-touch robotic cane, called CANINE, acts as a cane-like mobile assistant. The device improves the individual’s proprioception, or self-awareness in space, during walking, which in turn improves stability and balance.

[ ROAR Lab ]

During the second field experiment for DARPA’s OFFensive Swarm-Enabled Tactics (OFFSET) program, which took place at Fort Benning, Georgia, teams of autonomous air and ground robots tested tactics on a mission to isolate an urban objective. Similar to the way a firefighting crew establishes a boundary around a burning building, they first identified locations of interest and then created a perimeter around the focal point.

[ DARPA ]

I think there’s a bit of new footage here of Ghost Robotics’ Vision 60 quadruped walking around without sensors on unstructured terrain.

[ Ghost Robotics ]

If you’re as tired of passenger drone hype as I am, there’s absolutely no need to watch this video of NEC’s latest hover test.

[ AP ]

As researchers teach robots to perform more and more complex tasks, the need for realistic simulation environments is growing. Existing techniques for closing the reality gap by approximating real-world physics often require extensive real world data and/or thousands of simulation samples. This paper presents TuneNet, a new machine learning-based method to directly tune the parameters of one model to match another using an iterative residual tuning technique. TuneNet estimates the parameter difference between two models using a single observation from the target and minimal simulation, allowing rapid, accurate and sample-efficient parameter estimation.

The system can be trained via supervised learning over an auto-generated simulated dataset. We show that TuneNet can perform system identification, even when the true parameter values lie well outside the distribution seen during training, and demonstrate that simulators tuned with TuneNet outperform existing techniques for predicting rigid body motion. Finally, we show that our method can estimate real-world parameter values, allowing a robot to perform sim-to-real task transfer on a dynamic manipulation task unseen during training. We are also making a baseline implementation of our code available online.

[ Paper ]

Here’s an update on what GITAI has been up to with their telepresence astronaut-replacement robot.

[ GITAI ]

Curiosity captured this 360-degree panorama of a location on Mars called “Teal Ridge” on June 18, 2019. This location is part of a larger region the rover has been exploring called the “clay-bearing unit” on the side of Mount Sharp, which is inside Gale Crater. The scene is presented with a color adjustment that approximates white balancing to resemble how the rocks and sand would appear under daytime lighting conditions on Earth.

[ MSL ]

Some updates (in English) on ROS from ROSCon France. The first is a keynote from Brian Gerkey:

And this second video is from Omri Ben-Bassat, about how to keep your Anki Vector alive using ROS:

All of the ROSCon FR talks are available on Vimeo.

[ ROSCon FR ] Continue reading

Posted in Human Robots

#435632 DARPA Subterranean Challenge: Tunnel ...

The Tunnel Circuit of the DARPA Subterranean Challenge starts later this week at the NIOSH research mine just outside of Pittsburgh, Pennsylvania. From 15-22 August, 11 teams will send robots into a mine that they've never seen before, with the goal of making maps and locating items. All DARPA SubT events involve tunnels of one sort or another, but in this case, the “Tunnel Circuit” refers to mines as opposed to urban underground areas or natural caves. This month’s challenge is the first of three discrete events leading up to a huge final event in August of 2021.

While the Tunnel Circuit competition will be closed to the public, and media are only allowed access for a single day (which we'll be at, of course), DARPA has provided a substantial amount of information about what teams will be able to expect. We also have details from the SubT Integration Exercise, called STIX, which was a completely closed event that took place back in April. STIX was aimed at giving some teams (and DARPA) a chance to practice in a real tunnel environment.

For more general background on SubT, here are some articles to get you all caught up:

SubT: The Next DARPA Challenge for Robotics

Q&A with DARPA Program Manager Tim Chung

Meet The First Nine Teams

It makes sense to take a closer look at what happened at April's STIX exercise, because it is (probably) very similar to what teams will experience in the upcoming Tunnel Circuit. STIX took place at Edgar Experimental Mine in Colorado, and while no two mines are the same (and many are very, very different), there are enough similarities for STIX to have been a valuable experience for teams. Here's an overview video of the exercise from DARPA:

DARPA has also put together a much more detailed walkthrough of the STIX mine exercise, which gives you a sense of just how vast, complicated, and (frankly) challenging for robots the mine environment is:

So, that's the kind of thing that teams had to deal with back in April. Since the event was an exercise, rather than a competition, DARPA didn't really keep score, and wouldn't comment on the performance of individual teams. We've been trolling YouTube for STIX footage, though, to get a sense of how things went, and we found a few interesting videos.

Here's a nice overview from Team CERBERUS, which used drones plus an ANYmal quadruped:

Team CTU-CRAS also used drones, along with a tracked robot:

Team Robotika was brave enough to post video of a “fatal failure” experienced by its wheeled robot; the poor little bot gets rescued at about 7:00 in case you get worried:

So that was STIX. But what about the Tunnel Circuit competition this week? Here's a course preview video from DARPA:

It sort of looks like the NIOSH mine might be a bit less dusty than the Edgar mine was, but it could also be wetter and muddier. It’s hard to tell, because we’re just getting a few snapshots of what’s probably an enormous area with kilometers of tunnels that the robots will have to explore. But DARPA has promised “constrained passages, sharp turns, large drops/climbs, inclines, steps, ladders, and mud, sand, and/or water.” Combine that with the serious challenge to communications imposed by the mine itself, and robots will have to be both physically capable, and almost entirely autonomous. Which is, of course, exactly what DARPA is looking to test with this challenge.

Lastly, we had a chance to catch up with Tim Chung, Program Manager for the Subterranean Challenge at DARPA, and ask him a few brief questions about STIX and what we have to look forward to this week.

IEEE Spectrum: How did STIX go?

Tim Chung: It was a lot of fun! I think it gave a lot of the teams a great opportunity to really get a taste of what these types of real world environments look like, and also what DARPA has in store for them in the SubT Challenge. STIX I saw as an experiment—a learning experience for all the teams involved (as well as the DARPA team) so that we can continue our calibration.

What do you think teams took away from STIX, and what do you think DARPA took away from STIX?

I think the thing that teams took away was that, when DARPA hosts a challenge, we have very audacious visions for what the art of the possible is. And that's what we want—in my mind, the purpose of a DARPA Grand Challenge is to provide that inspiration of, ‘Holy cow, someone thinks we can do this!’ So I do think the teams walked away with a better understanding of what DARPA's vision is for the capabilities we're seeking in the SubT Challenge, and hopefully walked away with a better understanding of the technical, physical, even maybe mental challenges of doing this in the wild— which will all roll back into how they think about the problem, and how they develop their systems.

This was a collaborative exercise, so the DARPA field team was out there interacting with the other engineers, figuring out what their strengths and weaknesses and needs might be, and even understanding how to handle the robots themselves. That will help [strengthen] connections between these university teams and DARPA going forward. Across the board, I think that collaborative spirit is something we really wish to encourage, and something that the DARPA folks were able to take away.

What do we have to look forward to during the Tunnel Circuit?

The vision here is that the Tunnel Circuit is representative of one of the three subterranean subdomains, along with urban and cave. Characteristics of all of these three subdomains will be mashed together in an epic final course, so that teams will have to face hints of tunnel once again in that final event.

Without giving too much away, the NIOSH mine will be similar to the Edgar mine in that it's a human-made environment that supports mining operations and research. But of course, every site is different, and these differences, I think, will provide good opportunities for the teams to shine.

Again, we'll be visiting the NIOSH mine in Pennsylvania during the Tunnel Circuit and will post as much as we can from there. But if you’re an actual participant in the Subterranean Challenge, please tweet me @BotJunkie so that I can follow and help share live updates.

[ DARPA Subterranean Challenge ] Continue reading

Posted in Human Robots

#434580 How Genome Sequencing and Senolytics Can ...

The causes of aging are extremely complex and unclear. With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to find practical ways to extend our healthspan.

Here, in Part 2 of a series of blogs on longevity and vitality, I explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

In this blog I’ll cover two classes of emerging technologies:

Genome Sequencing and Editing;
Senolytics, Nutraceuticals & Pharmaceuticals.

Let’s dive in.

Genome Sequencing & Editing
Your genome is the software that runs your body.

A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity to disease, your lifespan, and so on.

Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean.

Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $5,000 in 2012.

Today, the cost of genome sequencing has dropped below $500, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.

This represents one of the most powerful and transformative technology revolutions in healthcare.

When we understand your genome, we’ll be able to understand how to optimize “you.”

We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later blog).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).

CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally-occurring biological system discovered in 1987 called CRISPR/Cas9.

Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.

Here’s how it works:

The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays.
The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions.
If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.

Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome.

A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.

2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers from the University of Chicago recently used CRISPR to genetically engineer cocaine resistance into mice.

Researchers at the University of Texas Southwestern Medical Center used CRISPR to reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs (DMD is the most common fatal genetic disease in children).

With great power comes great responsibility, and moral and ethical dilemmas.

In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera.

Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.

To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells.

Setting aside the significant ethical conversations, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.

Senolytics, Nutraceuticals & Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.

What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely.

These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse.

Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification, to localized inflammatory conditions such as osteoarthritis, to diminished lung function.

Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.

Prominent companies in the field include the following:

Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology and pulmonary disease.
Oisin Biotechnologiesis pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.
SIWA Therapeuticsis working on an immunotherapy approach to the problem of senescent cells.

In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.

Rapamycin
Originally extracted from bacteria found on Easter Island, Rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division.

Currently, rapamycin derivatives are widely used as immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.

PureTech Health subsidiary resTORbio (which started 2018 by going public) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.

Results of the drug’s recent clinical trial include:

Decreased incidence of infection
Improved influenza vaccination response
A 30.6 percent decrease in respiratory tract infections

Impressive, to say the least.

Metformin
Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients.

Researchers have found that Metformin also reduces oxidative stress and inflammation, which otherwise increase as we age.

There is strong evidence that Metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.

Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of Metformin’s protective effect against cancer.

Nutraceuticals and NAD+
Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.

NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.

The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.

Conclusion
These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.

The next blog in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.

We are edging closer to a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?

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Posted in Human Robots