Tag Archives: states

#438785 Video Friday: A Blimp For Your Cat

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
ICRA 2021 – May 30-5, 2021 – Xi'an, China
Let us know if you have suggestions for next week, and enjoy today's videos.

Shiny robotic cat toy blimp!

I am pretty sure this is Google Translate getting things wrong, but the About page mentions that the blimp will “take you to your destination after appearing in the death of God.”

[ NTT DoCoMo ] via [ RobotStart ]

If you have yet to see this real-time video of Perseverance landing on Mars, drop everything and watch it.

During the press conference, someone commented that this is the first time anyone on the team who designed and built this system has ever seen it in operation, since it could only be tested at the component scale on Earth. This landing system has blown my mind since Curiosity.

Here's a better look at where Percy ended up:

[ NASA ]

The fact that Digit can just walk up and down wet, slippery, muddy hills without breaking a sweat is (still) astonishing.

[ Agility Robotics ]

SkyMul wants drones to take over the task of tying rebar, which looks like just the sort of thing we'd rather robots be doing so that we don't have to:

The tech certainly looks promising, and SkyMul says that they're looking for some additional support to bring things to the pilot stage.

[ SkyMul ]

Thanks Eohan!

Flatcat is a pet-like, playful robot that reacts to touch. Flatcat feels everything exactly: Cuddle with it, romp around with it, or just watch it do weird things of its own accord. We are sure that flatcat will amaze you, like us, and caress your soul.

I don't totally understand it, but I want it anyway.

[ Flatcat ]

Thanks Oswald!

This is how I would have a romantic dinner date if I couldn't get together in person. Herman the UR3 and an OptiTrack system let me remotely make a romantic meal!

[ Dave's Armoury ]

Here, we propose a novel design of deformable propellers inspired by dragonfly wings. The structure of these propellers includes a flexible segment similar to the nodus on a dragonfly wing. This flexible segment can bend, twist and even fold upon collision, absorbing force upon impact and protecting the propeller from damage.

[ Paper ]

Thanks Van!

In the 1970s, The CIA​ created the world's first miniaturized unmanned aerial vehicle, or UAV, which was intended to be a clandestine listening device. The Insectothopter was never deployed operationally, but was still revolutionary for its time.

It may never have been deployed (not that they'll admit to, anyway), but it was definitely operational and could fly controllably.

[ CIA ]

Research labs are starting to get Digits, which means we're going to get a much better idea of what its limitations are.

[ Ohio State ]

This video shows the latest achievements for LOLA walking on undetected uneven terrain. The robot is technically blind, not using any camera-based or prior information on the terrain.

[ TUM ]

We define “robotic contact juggling” to be the purposeful control of the motion of a three-dimensional smooth object as it rolls freely on a motion-controlled robot manipulator, or “hand.” While specific examples of robotic contact juggling have been studied before, in this paper we provide the first general formulation and solution method for the case of an arbitrary smooth object in single-point rolling contact on an arbitrary smooth hand.

[ Paper ]

Thanks Fan!

A couple of new cobots from ABB, designed to work safely around humans.

[ ABB ]

Thanks Fan!

It's worth watching at least a little bit of Adam Savage testing Spot's new arm, because we get to see Spot try, fail, and eventually succeed at an autonomous door-opening behavior at the 10 minute mark.

[ Tested ]

SVR discusses diversity with guest speakers Dr. Michelle Johnson from the GRASP Lab at UPenn; Dr Ariel Anders from Women in Robotics and first technical hire at Robust.ai; Alka Roy from The Responsible Innovation Project; and Kenechukwu C. Mbanesi and Kenya Andrews from Black in Robotics. The discussion here is moderated by Dr. Ken Goldberg—artist, roboticist and Director of the CITRIS People and Robots Lab—and Andra Keay from Silicon Valley Robotics.

[ SVR ]

RAS presents a Soft Robotics Debate on Bioinspired vs. Biohybrid Design.

In this debate, we will bring together experts in Bioinspiration and Biohybrid design to discuss the necessary steps to make more competent soft robots. We will try to answer whether bioinspired research should focus more on developing new bioinspired material and structures or on the integration of living and artificial structures in biohybrid designs.

[ RAS SoRo ]

IFRR presents a Colloquium on Human Robot Interaction.

Across many application domains, robots are expected to work in human environments, side by side with people. The users will vary substantially in background, training, physical and cognitive abilities, and readiness to adopt technology. Robotic products are expected to not only be intuitive, easy to use, and responsive to the needs and states of their users, but they must also be designed with these differences in mind, making human-robot interaction (HRI) a key area of research.

[ IFRR ]

Vijay Kumar, Nemirovsky Family Dean and Professor at Penn Engineering, gives an introduction to ENIAC day and David Patterson, Pardee Professor of Computer Science, Emeritus at the University of California at Berkeley, speaks about the legacy of the ENIAC and its impact on computer architecture today. This video is comprised of lectures one and two of nine total lectures in the ENIAC Day series.

There are more interesting ENIAC videos at the link below, but we'll highlight this particular one, about the women of the ENIAC, also known as the First Programmers.

[ ENIAC Day ] Continue reading

Posted in Human Robots

#438779 Meet Catfish Charlie, the CIA’s ...

Photo: CIA Museum

CIA roboticists designed Catfish Charlie to take water samples undetected. Why they wanted a spy fish for such a purpose remains classified.

In 1961, Tom Rogers of the Leo Burnett Agency created Charlie the Tuna, a jive-talking cartoon mascot and spokesfish for the StarKist brand. The popular ad campaign ran for several decades, and its catchphrase “Sorry, Charlie” quickly hooked itself in the American lexicon.

When the CIA’s Office of Advanced Technologies and Programs started conducting some fish-focused research in the 1990s, Charlie must have seemed like the perfect code name. Except that the CIA’s Charlie was a catfish. And it was a robot.

More precisely, Charlie was an unmanned underwater vehicle (UUV) designed to surreptitiously collect water samples. Its handler controlled the fish via a line-of-sight radio handset. Not much has been revealed about the fish’s construction except that its body contained a pressure hull, ballast system, and communications system, while its tail housed the propulsion. At 61 centimeters long, Charlie wouldn’t set any biggest-fish records. (Some species of catfish can grow to 2 meters.) Whether Charlie reeled in any useful intel is unknown, as details of its missions are still classified.

For exploring watery environments, nothing beats a robot
The CIA was far from alone in its pursuit of UUVs nor was it the first agency to do so. In the United States, such research began in earnest in the 1950s, with the U.S. Navy’s funding of technology for deep-sea rescue and salvage operations. Other projects looked at sea drones for surveillance and scientific data collection.

Aaron Marburg, a principal electrical and computer engineer who works on UUVs at the University of Washington’s Applied Physics Laboratory, notes that the world’s oceans are largely off-limits to crewed vessels. “The nature of the oceans is that we can only go there with robots,” he told me in a recent Zoom call. To explore those uncharted regions, he said, “we are forced to solve the technical problems and make the robots work.”

Image: Thomas Wells/Applied Physics Laboratory/University of Washington

An oil painting commemorates SPURV, a series of underwater research robots built by the University of Washington’s Applied Physics Lab. In nearly 400 deployments, no SPURVs were lost.

One of the earliest UUVs happens to sit in the hall outside Marburg’s office: the Self-Propelled Underwater Research Vehicle, or SPURV, developed at the applied physics lab beginning in the late ’50s. SPURV’s original purpose was to gather data on the physical properties of the sea, in particular temperature and sound velocity. Unlike Charlie, with its fishy exterior, SPURV had a utilitarian torpedo shape that was more in line with its mission. Just over 3 meters long, it could dive to 3,600 meters, had a top speed of 2.5 m/s, and operated for 5.5 hours on a battery pack. Data was recorded to magnetic tape and later transferred to a photosensitive paper strip recorder or other computer-compatible media and then plotted using an IBM 1130.

Over time, SPURV’s instrumentation grew more capable, and the scope of the project expanded. In one study, for example, SPURV carried a fluorometer to measure the dispersion of dye in the water, to support wake studies. The project was so successful that additional SPURVs were developed, eventually completing nearly 400 missions by the time it ended in 1979.

Working on underwater robots, Marburg says, means balancing technical risks and mission objectives against constraints on funding and other resources. Support for purely speculative research in this area is rare. The goal, then, is to build UUVs that are simple, effective, and reliable. “No one wants to write a report to their funders saying, ‘Sorry, the batteries died, and we lost our million-dollar robot fish in a current,’ ” Marburg says.

A robot fish called SoFi
Since SPURV, there have been many other unmanned underwater vehicles, of various shapes and sizes and for various missions, developed in the United States and elsewhere. UUVs and their autonomous cousins, AUVs, are now routinely used for scientific research, education, and surveillance.

At least a few of these robots have been fish-inspired. In the mid-1990s, for instance, engineers at MIT worked on a RoboTuna, also nicknamed Charlie. Modeled loosely on a blue-fin tuna, it had a propulsion system that mimicked the tail fin of a real fish. This was a big departure from the screws or propellers used on UUVs like SPURV. But this Charlie never swam on its own; it was always tethered to a bank of instruments. The MIT group’s next effort, a RoboPike called Wanda, overcame this limitation and swam freely, but never learned to avoid running into the sides of its tank.

Fast-forward 25 years, and a team from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) unveiled SoFi, a decidedly more fishy robot designed to swim next to real fish without disturbing them. Controlled by a retrofitted Super Nintendo handset, SoFi could dive more than 15 meters, control its own buoyancy, and swim around for up to 40 minutes between battery charges. Noting that SoFi’s creators tested their robot fish in the gorgeous waters off Fiji, IEEE Spectrum’s Evan Ackerman noted, “Part of me is convinced that roboticists take on projects like these…because it’s a great way to justify a trip somewhere exotic.”

SoFi, Wanda, and both Charlies are all examples of biomimetics, a term coined in 1974 to describe the study of biological mechanisms, processes, structures, and substances. Biomimetics looks to nature to inspire design.

Sometimes, the resulting technology proves to be more efficient than its natural counterpart, as Richard James Clapham discovered while researching robotic fish for his Ph.D. at the University of Essex, in England. Under the supervision of robotics expert Huosheng Hu, Clapham studied the swimming motion of Cyprinus carpio, the common carp. He then developed four robots that incorporated carplike swimming, the most capable of which was iSplash-II. When tested under ideal conditions—that is, a tank 5 meters long, 2 meters wide, and 1.5 meters deep—iSpash-II obtained a maximum velocity of 11.6 body lengths per second (or about 3.7 m/s). That’s faster than a real carp, which averages a top velocity of 10 body lengths per second. But iSplash-II fell short of the peak performance of a fish darting quickly to avoid a predator.

Of course, swimming in a test pool or placid lake is one thing; surviving the rough and tumble of a breaking wave is another matter. The latter is something that roboticist Kathryn Daltorio has explored in depth.

Daltorio, an assistant professor at Case Western Reserve University and codirector of the Center for Biologically Inspired Robotics Research there, has studied the movements of cockroaches, earthworms, and crabs for clues on how to build better robots. After watching a crab navigate from the sandy beach to shallow water without being thrown off course by a wave, she was inspired to create an amphibious robot with tapered, curved feet that could dig into the sand. This design allowed her robot to withstand forces up to 138 percent of its body weight.

Photo: Nicole Graf

This robotic crab created by Case Western’s Kathryn Daltorio imitates how real crabs grab the sand to avoid being toppled by waves.

In her designs, Daltorio is following architect Louis Sullivan’s famous maxim: Form follows function. She isn’t trying to imitate the aesthetics of nature—her robot bears only a passing resemblance to a crab—but rather the best functionality. She looks at how animals interact with their environments and steals evolution’s best ideas.

And yet, Daltorio admits, there is also a place for realistic-looking robotic fish, because they can capture the imagination and spark interest in robotics as well as nature. And unlike a hyperrealistic humanoid, a robotic fish is unlikely to fall into the creepiness of the uncanny valley.

In writing this column, I was delighted to come across plenty of recent examples of such robotic fish. Ryomei Engineering, a subsidiary of Mitsubishi Heavy Industries, has developed several: a robo-coelacanth, a robotic gold koi, and a robotic carp. The coelacanth was designed as an educational tool for aquariums, to present a lifelike specimen of a rarely seen fish that is often only known by its fossil record. Meanwhile, engineers at the University of Kitakyushu in Japan created Tai-robot-kun, a credible-looking sea bream. And a team at Evologics, based in Berlin, came up with the BOSS manta ray.

Whatever their official purpose, these nature-inspired robocreatures can inspire us in return. UUVs that open up new and wondrous vistas on the world’s oceans can extend humankind’s ability to explore. We create them, and they enhance us, and that strikes me as a very fair and worthy exchange.

This article appears in the March 2021 print issue as “Catfish, Robot, Swimmer, Spy.”

About the Author
Allison Marsh is an associate professor of history at the University of South Carolina and codirector of the university’s Ann Johnson Institute for Science, Technology & Society. Continue reading

Posted in Human Robots

#438755 Soft Legged Robot Uses Pneumatic ...

Soft robots are inherently safe, highly resilient, and potentially very cheap, making them promising for a wide array of applications. But development on them has been a bit slow relative to other areas of robotics, at least partially because soft robots can’t directly benefit from the massive increase in computing power and sensor and actuator availability that we’ve seen over the last few decades. Instead, roboticists have had to get creative to find ways of achieving the functionality of conventional robotics components using soft materials and compatible power sources.

In the current issue of Science Robotics, researchers from UC San Diego demonstrate a soft walking robot with four legs that moves with a turtle-like gait controlled by a pneumatic circuit system made from tubes and valves. This air-powered nervous system can actuate multiple degrees of freedom in sequence from a single source of pressurized air, offering a huge reduction in complexity and bringing a very basic form of decision making onto the robot itself.

Generally, when people talk about soft robots, the robots are only mostly soft. There are some components that are very difficult to make soft, including pressure sources and the necessary electronics to direct that pressure between different soft actuators in a way that can be used for propulsion. What’s really cool about this robot is that researchers have managed to take a pressure source (either a single tether or an onboard CO2 cartridge) and direct it to four different legs, each with three different air chambers, using an oscillating three valve circuit made entirely of soft materials.

Photo: UCSD

The pneumatic circuit that powers and controls the soft quadruped.

The inspiration for this can be found in biology—natural organisms, including quadrupeds, use nervous system components called central pattern generators (CPGs) to prompt repetitive motions with limbs that are used for walking, flying, and swimming. This is obviously more complicated in some organisms than in others, and is typically mediated by sensory feedback, but the underlying structure of a CPG is basically just a repeating circuit that drives muscles in sequence to produce a stable, continuous gait. In this case, we’ve got pneumatic muscles being driven in opposing pairs, resulting in a diagonal couplet gait, where diagonally opposed limbs rotate forwards and backwards at the same time.

Diagram: Science Robotics

(J) Pneumatic logic circuit for rhythmic leg motion. A constant positive pressure source (P+) applied to three inverter components causes a high-pressure state to propagate around the circuit, with a delay at each inverter. While the input to one inverter is high, the attached actuator (i.e., A1, A2, or A3) is inflated. This sequence of high-pressure states causes each pair of legs of the robot to rotate in a direction determined by the pneumatic connections. (K) By reversing the sequence of activation of the pneumatic oscillator circuit, the attached actuators inflate in a new sequence (A1, A3, and A2), causing (L) the legs of the robot to rotate in reverse. (M) Schematic bottom view of the robot with the directions of leg motions indicated for forward walking.

Diagram: Science Robotics

Each of the valves acts as an inverter by switching the normally closed half (top) to open and the normally open half (bottom) to closed.

The circuit itself is made up of three bistable pneumatic valves connected by tubing that acts as a delay by providing resistance to the gas moving through it that can be adjusted by altering the tube’s length and inner diameter. Within the circuit, the movement of the pressurized gas acts as both a source of energy and as a signal, since wherever the pressure is in the circuit is where the legs are moving. The simplest circuit uses only three valves, and can keep the robot walking in one single direction, but more valves can add more complex leg control options. For example, the researchers were able to use seven valves to tune the phase offset of the gait, and even just one additional valve (albeit of a slightly more complex design) could enable reversal of the system, causing the robot to walk backwards in response to input from a soft sensor. And with another complex valve, a manual (tethered) controller could be used for omnidirectional movement.

This work has some similarities to the rover that JPL is developing to explore Venus—that rover isn’t a soft robot, of course, but it operates under similar constraints in that it can’t rely on conventional electronic systems for autonomous navigation or control. It turns out that there are plenty of clever ways to use mechanical (or in this case, pneumatic) intelligence to make robots with relatively complex autonomous behaviors, meaning that in the future, soft (or soft-ish) robots could find valuable roles in situations where using a non-compliant system is not a good option.

For more on why we should be so excited about soft robots and just how soft a soft robot needs to be, we spoke with Michael Tolley, who runs the Bioinspired Robotics and Design Lab at UCSD, and Dylan Drotman, the paper’s first author.

IEEE Spectrum: What can soft robots do for us that more rigid robotic designs can’t?

Michael Tolley: At the very highest level, one of the fundamental assumptions of robotics is that you have rigid bodies connected at joints, and all your motion happens at these joints. That's a really nice approach because it makes the math easy, frankly, and it simplifies control. But when you look around us in nature, even though animals do have bones and joints, the way we interact with the world is much more complicated than that simple story. I’m interested in where we can take advantage of material properties in robotics. If you look at robots that have to operate in very unknown environments, I think you can build in some of the intelligence for how to deal with those environments into the body of the robot itself. And that’s the category this work really falls under—it's about navigating the world.

Dylan Drotman: Walking through confined spaces is a good example. With the rigid legged robot, you would have to completely change the way that the legs move to walk through a confined space, while if you have flexible legs, like the robot in our paper, you can use relatively simple control strategies to squeeze through an area you wouldn’t be able to get through with a rigid system.

How smart can a soft robot get?

Drotman: Right now we have a sensor on the front that's connected through a fluidic transmission to a bistable valve that causes the robot to reverse. We could add other sensors around the robot to allow it to change direction whenever it runs into an obstacle to effectively make an electronics-free version of a Roomba.

Tolley: Stepping back a little bit from that, one could make an argument that we’re using basic memory elements to generate very basic signals. There’s nothing in principle that would stop someone from making a pneumatic computer—it’s just very complicated to make something that complex. I think you could build on this and do more intelligent decision making, but using this specific design and the components we’re using, it’s likely to be things that are more direct responses to the environment.

How well would robots like these scale down?

Drotman: At the moment we’re manufacturing these components by hand, so the idea would be to make something more like a printed circuit board instead, and looking at how the channel sizes and the valve design would affect the actuation properties. We’ll also be coming up with new circuits, and different designs for the circuits themselves.

Tolley: Down to centimeter or millimeter scale, I don’t think you’d have fundamental fluid flow problems. I think you’re going to be limited more by system design constraints. You’ll have to be able to locomote while carrying around your pressure source, and possibly some other components that are also still rigid. When you start to talk about really small scales, though, it's not as clear to me that you really need an intrinsically soft robot. If you think about insects, their structural geometry can make them behave like they’re soft, but they’re not intrinsically soft.

Should we be thinking about soft robots and compliant robots in the same way, or are they fundamentally different?

Tolley: There’s certainly a connection between the two. You could have a compliant robot that behaves in a very similar way to an intrinsically soft robot, or a robot made of intrinsically soft materials. At that point, it comes down to design and manufacturing and practical limitations on what you can make. I think when you get down to small scales, the two sort of get connected.

There was some interesting work several years ago on using explosions to power soft robots. Is that still a thing?

Tolley: One of the opportunities with soft robots is that with material compliance, you have the potential to store energy. I think there’s exciting potential there for rapid motion with a soft body. Combustion is one way of doing that with power coming from a chemical source all at once, but you could also use a relatively weak muscle that over time stores up energy in a soft body and then releases it.

Is it realistic to expect complete softness from soft robots, or will they likely always have rigid components because they have to store or generate and move pressurized gas somehow?

Tolley: If you look in nature, you do have soft pumps like the heart, but although it’s soft, it’s still relatively stiff. Like, if you grab a heart, it’s not totally squishy. I haven’t done it, but I’d imagine. If you have a container that you’re pressurizing, it has to be stiff enough to not just blow up like a balloon. Certainly pneumatics or hydraulics are not the only way to go for soft actuators; there has been some really nice work on smart muscles and smart materials like hydraulic electrostatic (HASEL) actuators. They seem promising, but all of these actuators have challenges. We’ve chosen to stick with pressurized pneumatics in the near term; longer term, I think you’ll start to see more of these smart material actuators become more practical.

Personally, I don’t have any problem with soft robots having some rigid components. Most animals on land have some rigid components, but they can still take advantage of being soft, so it’s probably going to be a combination. But I do also like the vision of making an entirely soft, squishy thing. Continue reading

Posted in Human Robots

#437982 Superintelligent AI May Be Impossible to ...

It may be theoretically impossible for humans to control a superintelligent AI, a new study finds. Worse still, the research also quashes any hope for detecting such an unstoppable AI when it’s on the verge of being created.

Slightly less grim is the timetable. By at least one estimate, many decades lie ahead before any such existential computational reckoning could be in the cards for humanity.

Alongside news of AI besting humans at games such as chess, Go and Jeopardy have come fears that superintelligent machines smarter than the best human minds might one day run amok. “The question about whether superintelligence could be controlled if created is quite old,” says study lead author Manuel Alfonseca, a computer scientist at the Autonomous University of Madrid. “It goes back at least to Asimov’s First Law of Robotics, in the 1940s.”

The Three Laws of Robotics, first introduced in Isaac Asimov's 1942 short story “Runaround,” are as follows:

A robot may not injure a human being or, through inaction, allow a human being to come to harm.
A robot must obey the orders given it by human beings except where such orders would conflict with the First Law.
A robot must protect its own existence as long as such protection does not conflict with the First or Second Laws.

In 2014, philosopher Nick Bostrom, director of the Future of Humanity Institute at the University of Oxford, not only explored ways in which a superintelligent AI could destroy us but also investigated potential control strategies for such a machine—and the reasons they might not work.

Bostrom outlined two possible types of solutions of this “control problem.” One is to control what the AI can do, such as keeping it from connecting to the Internet, and the other is to control what it wants to do, such as teaching it rules and values so it would act in the best interests of humanity. The problem with the former is that Bostrom thought a supersmart machine could probably break free from any bonds we could make. With the latter, he essentially feared that humans might not be smart enough to train a superintelligent AI.

Now Alfonseca and his colleagues suggest it may be impossible to control a superintelligent AI, due to fundamental limits inherent to computing itself. They detailed their findings this month in the Journal of Artificial Intelligence Research.

The researchers suggested that any algorithm that sought to ensure a superintelligent AI cannot harm people had to first simulate the machine’s behavior to predict the potential consequences of its actions. This containment algorithm then would need to halt the supersmart machine if it might indeed do harm.

However, the scientists said it was impossible for any containment algorithm to simulate the AI’s behavior and predict with absolute certainty whether its actions might lead to harm. The algorithm could fail to correctly simulate the AI’s behavior or accurately predict the consequences of the AI’s actions and not recognize such failures.

“Asimov’s first law of robotics has been proved to be incomputable,” Alfonseca says, “and therefore unfeasible.”

We may not even know if we have created a superintelligent machine, the researchers say. This is a consequence of Rice’s theorem, which essentially states that one cannot in general figure anything out about what a computer program might output just by looking at the program, Alfonseca explains.

On the other hand, there’s no need to spruce up the guest room for our future robot overlords quite yet. Three important caveats to the research still leave plenty of uncertainty to the group’s predictions.

First, Alfonseca estimates AI’s moment of truth remains, he says, “At least two centuries in the future.”

Second, he says researchers do not know if so-called artificial general intelligence, also known as strong AI, is theoretically even feasible. “That is, a machine as intelligent as we are in an ample variety of fields,” Alfonseca explains.

Last, Alfonseca says, “We have not proved that superintelligences can never be controlled—only that they can’t always be controlled.”

Although it may not be possible to control a superintelligent artificial general intelligence, it should be possible to control a superintelligent narrow AI—one specialized for certain functions instead of being capable of a broad range of tasks like humans. “We already have superintelligences of this type,” Alfonseca says. “For instance, we have machines that can compute mathematics much faster than we can. This is [narrow] superintelligence, isn’t it?” Continue reading

Posted in Human Robots

#437957 Meet Assembloids, Mini Human Brains With ...

It’s not often that a twitching, snowman-shaped blob of 3D human tissue makes someone’s day.

But when Dr. Sergiu Pasca at Stanford University witnessed the tiny movement, he knew his lab had achieved something special. You see, the blob was evolved from three lab-grown chunks of human tissue: a mini-brain, mini-spinal cord, and mini-muscle. Each individual component, churned to eerie humanoid perfection inside bubbling incubators, is already a work of scientific genius. But Pasca took the extra step, marinating the three components together inside a soup of nutrients.

The result was a bizarre, Lego-like human tissue that replicates the basic circuits behind how we decide to move. Without external prompting, when churned together like ice cream, the three ingredients physically linked up into a fully functional circuit. The 3D mini-brain, through the information highway formed by the artificial spinal cord, was able to make the lab-grown muscle twitch on demand.

In other words, if you think isolated mini-brains—known formally as brain organoids—floating in a jar is creepy, upgrade your nightmares. The next big thing in probing the brain is assembloids—free-floating brain circuits—that now combine brain tissue with an external output.

The end goal isn’t to freak people out. Rather, it’s to recapitulate our nervous system, from input to output, inside the controlled environment of a Petri dish. An autonomous, living brain-spinal cord-muscle entity is an invaluable model for figuring out how our own brains direct the intricate muscle movements that allow us stay upright, walk, or type on a keyboard.

It’s the nexus toward more dexterous brain-machine interfaces, and a model to understand when brain-muscle connections fail—as in devastating conditions like Lou Gehrig’s disease or Parkinson’s, where people slowly lose muscle control due to the gradual death of neurons that control muscle function. Assembloids are a sort of “mini-me,” a workaround for testing potential treatments on a simple “replica” of a person rather than directly on a human.

From Organoids to Assembloids
The miniature snippet of the human nervous system has been a long time in the making.

It all started in 2014, when Dr. Madeleine Lancaster, then a post-doc at Stanford, grew a shockingly intricate 3D replica of human brain tissue inside a whirling incubator. Revolutionarily different than standard cell cultures, which grind up brain tissue to reconstruct as a flat network of cells, Lancaster’s 3D brain organoids were incredibly sophisticated in their recapitulation of the human brain during development. Subsequent studies further solidified their similarity to the developing brain of a fetus—not just in terms of neuron types, but also their connections and structure.

With the finding that these mini-brains sparked with electrical activity, bioethicists increasingly raised red flags that the blobs of human brain tissue—no larger than the size of a pea at most—could harbor the potential to develop a sense of awareness if further matured and with external input and output.

Despite these concerns, brain organoids became an instant hit. Because they’re made of human tissue—often taken from actual human patients and converted into stem-cell-like states—organoids harbor the same genetic makeup as their donors. This makes it possible to study perplexing conditions such as autism, schizophrenia, or other brain disorders in a dish. What’s more, because they’re grown in the lab, it’s possible to genetically edit the mini-brains to test potential genetic culprits in the search for a cure.

Yet mini-brains had an Achilles’ heel: not all were made the same. Rather, depending on the region of the brain that was reverse engineered, the cells had to be persuaded by different cocktails of chemical soups and maintained in isolation. It was a stark contrast to our own developing brains, where regions are connected through highways of neural networks and work in tandem.

Pasca faced the problem head-on. Betting on the brain’s self-assembling capacity, his team hypothesized that it might be possible to grow different mini-brains, each reflecting a different brain region, and have them fuse together into a synchronized band of neuron circuits to process information. Last year, his idea paid off.

In one mind-blowing study, his team grew two separate portions of the brain into blobs, one representing the cortex, the other a deeper part of the brain known to control reward and movement, called the striatum. Shockingly, when put together, the two blobs of human brain tissue fused into a functional couple, automatically establishing neural highways that resulted in one of the most sophisticated recapitulations of a human brain. Pasca crowned this tissue engineering crème-de-la-crème “assembloids,” a portmanteau between “assemble” and “organoids.”

“We have demonstrated that regionalized brain spheroids can be put together to form fused structures called brain assembloids,” said Pasca at the time.” [They] can then be used to investigate developmental processes that were previously inaccessible.”

And if that’s possible for wiring up a lab-grown brain, why wouldn’t it work for larger neural circuits?

Assembloids, Assemble
The new study is the fruition of that idea.

The team started with human skin cells, scraped off of eight healthy people, and transformed them into a stem-cell-like state, called iPSCs. These cells have long been touted as the breakthrough for personalized medical treatment, before each reflects the genetic makeup of its original host.

Using two separate cocktails, the team then generated mini-brains and mini-spinal cords using these iPSCs. The two components were placed together “in close proximity” for three days inside a lab incubator, gently floating around each other in an intricate dance. To the team’s surprise, under the microscope using tracers that glow in the dark, they saw highways of branches extending from one organoid to the other like arms in a tight embrace. When stimulated with electricity, the links fired up, suggesting that the connections weren’t just for show—they’re capable of transmitting information.

“We made the parts,” said Pasca, “but they knew how to put themselves together.”

Then came the ménage à trois. Once the mini-brain and spinal cord formed their double-decker ice cream scoop, the team overlaid them onto a layer of muscle cells—cultured separately into a human-like muscular structure. The end result was a somewhat bizarre and silly-looking snowman, made of three oddly-shaped spherical balls.

Yet against all odds, the brain-spinal cord assembly reached out to the lab-grown muscle. Using a variety of tools, including measuring muscle contraction, the team found that this utterly Frankenstein-like snowman was able to make the muscle component contract—in a way similar to how our muscles twitch when needed.

“Skeletal muscle doesn’t usually contract on its own,” said Pasca. “Seeing that first twitch in a lab dish immediately after cortical stimulation is something that’s not soon forgotten.”

When tested for longevity, the contraption lasted for up to 10 weeks without any sort of breakdown. Far from a one-shot wonder, the isolated circuit worked even better the longer each component was connected.

Pasca isn’t the first to give mini-brains an output channel. Last year, the queen of brain organoids, Lancaster, chopped up mature mini-brains into slices, which were then linked to muscle tissue through a cultured spinal cord. Assembloids are a step up, showing that it’s possible to automatically sew multiple nerve-linked structures together, such as brain and muscle, sans slicing.

The question is what happens when these assembloids become more sophisticated, edging ever closer to the inherent wiring that powers our movements. Pasca’s study targets outputs, but what about inputs? Can we wire input channels, such as retinal cells, to mini-brains that have a rudimentary visual cortex to process those examples? Learning, after all, depends on examples of our world, which are processed inside computational circuits and delivered as outputs—potentially, muscle contractions.

To be clear, few would argue that today’s mini-brains are capable of any sort of consciousness or awareness. But as mini-brains get increasingly more sophisticated, at what point can we consider them a sort of AI, capable of computation or even something that mimics thought? We don’t yet have an answer—but the debates are on.

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