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Hardly a day goes by without a research study or article published talking sh*t—or more precisely, talking about the gut microbiome. When it comes to cutting-edge innovations in medicine, all signs point to the microbiome. Maybe we should have listened to Hippocrates: “All disease begins in the gut.”
Your microbiome is mostly located in your gut and contains trillions of little guys and gals called microbes. If you want to optimize your health, biohack your body, make progress against chronic disease, or know which foods are right for you—almost all of this information can be found in your microbiome.
My company, Viome, offers technology to measure your microscopic organisms and their behavior at a molecular level. Think of it as the Instagram of your inner world. A snapshot of what’s happening inside your body. New research about the microbiome is changing our understanding of who we are as humans and how the human body functions.
It turns out the microbiome may be mission control for your body and mind. Your healthy microbiome is part best friend, part power converter, part engine, and part pharmacist. At Viome, we’re working to analyze these microbial functions and recommend a list of personalized food and supplements to keep these internal complex machines in a finely tuned balance.
We now have more information than ever before about what your microbiome is doing, and it’s going to help you and the rest of the world do a whole lot better. The new insights emerging from microbiome research are changing our perception of what keeps us healthy and what makes us sick. This new understanding of the microbiome activities may put an end to conflicting food advice and make fad diets a thing of the past.
What are these new insights showing us? The information is nothing short of mind-blowing. The value of your poop just got an upgrade.
Here are some of the amazing things we’ve learned from our work at Viome.
1. Was Popeye wrong? Why “health food” isn’t necessarily healthy.
Each week there is a new fad diet released, discussed, and followed. The newest “research” shows that this is now the superfood to eat for everyone. But, too often, the fad diet is just a regurgitation of what worked for one person and shouldn’t be followed by everyone else.
For example, we’ve been told to eat our greens and that greens and nuts are “anti-inflammatory,” but this is actually not always true. Spinach, bran, rhubarb, beets, nuts, and nut butters all contain oxalate. We now know that oxalate-containing food can be harmful, unless you have the microbes present that can metabolize it into a non-harmful substance.
30% of Viome customers do not have the microbes to metabolize oxalates properly. In other words, “healthy foods” like spinach are actually not healthy for these people.
Looks like not everyone should follow Popeye’s food plan.
2. Aren’t foods containing “antioxidants” always good for everyone?
Just like oxalates, polyphenols in foods are usually considered very healthy, but unless you have microbes that utilize specific polyphenols, you may not get full benefit from them. One example is a substance found in these foods called ellagic acid. We can detect if your microbiome is metabolizing ellagic acid and converting it into urolithin A. It is only the urolithin A that has anti-inflammatory and antioxidant effects. Without the microbes to do this conversion you will not benefit from the ellagic acid in foods.
Examples: Walnuts, raspberries, pomegranate, blackberries, pecans, and cranberries all contain ellagic acid.
We have analyzed tens of thousands of people, and only about 50% of the people actually benefit from eating more foods containing ellagic acid.
3. You’re probably eating too much protein (and it may be causing inflammation).
When you think high-protein diet, you think paleo, keto, and high-performance diets.
Protein is considered good for you. It helps build muscle and provide energy—but if you eat too much, it can cause inflammation and decrease longevity.
We can analyze the activity of your microbiome to determine if you are eating too much protein that feeds protein-fermenting bacteria like Alistipes putredinis and Tannerella forsythia, and if these organisms are producing harmful substances such as ammonia, hydrogen sulfide, p-cresol, or putrescine. These substances can damage your gut lining and lead to things like leaky gut.
4. Something’s fishy. Are “healthy foods” causing heart disease?
Choline in certain foods can get converted by bacteria into a substance called trimethylamine (TMA) that is associated with heart disease when it gets absorbed into your body and converted to TMAO. However, TMA conversion doesn’t happen in individuals without these types of bacteria in their microbiome.
We can see the TMA production pathways and many of the gammaproteobacteria that do this conversion.
What foods contain choline? Liver, salmon, chickpeas, split peas, eggs, navy beans, peanuts, and many others.
Before you decide to go full-on pescatarian or paleo, you may want to check if your microbiome is producing TMA with that salmon or steak.
5. Hold up, Iron Man. We can see inflammation from too much iron.
Minerals like iron in your food can, in certain inflammatory microbial environments, promote growth of pathogens like Esherichia, Shigella, and Salmonella.
Maybe it wasn’t just that raw chicken that gave you food poisoning, but your toxic microbiome that made you sick.
On the other hand, when you don’t have enough iron, you could become anemic leading to weakness and shortness of breath.
So, just like Iron Man, it’s about finding your balance so that you can fly.
6. Are you anxious or stressed? Your poop will tell you.
Our gut and brain are connected via the vagus nerve. A large majority of neurotransmitters are either produced or consumed by our microbiome. In fact, some 90% of all serotonin (a feel-good neurotransmitter) is produced by your gut microbiome and not by your brain.
When you have a toxic microbiome that’s producing a large amount of toxins like hydrogen sulfide, the lining of your gut starts to deteriorate into what’s known as leaky gut. Think of leaky gut as your gut not having healthy borders or boundaries. And when this happens, all kinds of disease can emerge. When the barrier of the gut breaks down, it starts a chain reaction causing low-grade chronic inflammation—which has been identified as a potential source of depression and higher levels of anxiety, in addition to many other chronic diseases.
We’re not saying you shouldn’t meditate, but if you want to get the most out of your meditation and really reduce your stress levels, make sure you are eating the right food that promotes a healthy microbiome.
7. Your microbiome is better than Red Bull.
If you want more energy, get your microbiome back into balance.
No you don’t need three pots of coffee to keep you going, you just need a balanced microbiome.
Your microbiome is responsible for calorie extraction, or creating energy, through pathways such as the Tricarboxylic acid cycle. Our bodies depend on the energy that our microbiome produces.
How much energy we get from our food is dependent on how efficient our microbiome is at converting the food into energy. High-performing microbiomes are excellent at converting food into energy. This is great when you are an athlete and need the extra energy, but if you don’t use up the energy it may be the source of some of those unwanted pounds.
If the microbes can’t or won’t metabolize the glucose (sugar) that you eat, it will be stored as fat. If the microbes are extracting too many calories from your food or producing lipopolysaccharides (LPS) and causing metabolic endotoxemia leading to activation of toll-like receptors and insulin resistance you may end up storing what you eat as fat.
Think of your microbiome as Doc Brown’s car from the future—it can take pretty much anything and turn it into fuel if it’s strong and resilient enough.
8. We can see your joint pain in your poop.
Got joint pain? Your microbiome can tell you why.
Lipopolysaccharide (LPS) is a key pro-inflammatory molecule made by some of your microbes. If your microbes are making too much LPS, it can wreak havoc on your immune system by putting it into overdrive. When your immune system goes on the warpath there is often collateral damage to your joints and other body parts.
Perhaps balancing your microbiome is a better solution than reaching for the glucosamine. Think of your microbiome as the top general of your immune army. It puts your immune system through basic training and determines when it goes to war.
Ideally, your immune system wins the quick battle and gets some rest, but sometimes if your microbiome keeps it on constant high alert it becomes a long, drawn-out war resulting in chronic inflammation and chronic diseases.
Are you really “getting older” or is your microbiome just making you “feel” older because it keeps giving warnings to your immune system ultimately leading to chronic pain?
Before you throw in the towel on your favorite activities, check your microbiome. And, if you have anything with “itis” in it, it’s possible that when you balance your microbiome the inflammation from your “itis” will be reduced.
9. Your gut is doing the talking for your mouth.
When you have low stomach acid, your mouth bacteria makes it down to your GI tract.
Stomach acid is there to protect you from the bacteria in your mouth and the parasites and fungi that are in your food. If you don’t have enough of it, the bacteria in your mouth will invade your gut. This invasion is associated with and a risk factor for autoimmune disease and inflammation in the gut.
We are learning that low stomach acid is perhaps one of the major causes of chronic disease. This stomach acid is essential to kill mouth bacteria and help us digest our food.
What kinds of things cause low stomach acid? Stress and antacids like Nexium, Zantac, and Prilosec.
10. Carbs can be protein precursors.
Rejoice! Perhaps carbs aren’t as bad as we thought (as long as your microbiome is up to the task). We can see if some of the starches you eat can be made into amino acids by the microbiome.
Our microbiome makes 20% of our branched-chain amino acids (BCAAs) for us, and it will adapt to make these vital BCAAs for us in almost any way it can.
Essentially, your microbiome is hooking up carbons and hydrogens into different formulations of BCAAs, depending on what you feed it. The microbiome is excellent at adapting and pivoting based on the food you feed it and the environment that it’s in.
So, good news: Carbs are protein precursors, as long as you have the right microbiome.
Stop Talking Sh*t Now
Your microbiome is a world class entrepreneur that can take low-grade sources of food and turn them into valuable and useable energy.
You have a best friend and confidant within you that is working wonders to make sure you have energy and that all of your needs are met.
And, just like a best friend, if you take great care of your microbiome, it will take great care of you.
Given the research emerging daily about the microbiome and its importance on your quality of life, prioritizing the health of your microbiome is essential.
When you have a healthy microbiome, you’ll have a healthy life.
It’s now clear that some of the greatest insights for your health will come from your poop.
It’s time to stop talking sh*t and get your sh*t together. Your life may depend on it.
Viome can help you identify what your microbiome is actually doing. The combination of Viome’s metatranscriptomic technology and cutting-edge artificial intelligence is paving a brand new path forward for microbiome health.
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Move over, deep learning. Neuromorphic computing—the next big thing in artificial intelligence—is on fire.
Just last week, two studies individually unveiled computer chips modeled after information processing in the human brain.
The first, published in Nature Materials, found a perfect solution to deal with unpredictability at synapses—the gap between two neurons that transmit and store information. The second, published in Science Advances, further amped up the system’s computational power, filling synapses with nanoclusters of supermagnetic material to bolster information encoding.
The result? Brain-like hardware systems that compute faster—and more efficiently—than the human brain.
“Ultimately we want a chip as big as a fingernail to replace one big supercomputer,” said Dr. Jeehwan Kim, who led the first study at MIT in Cambridge, Massachusetts.
Experts are hopeful.
“The field’s full of hype, and it’s nice to see quality work presented in an objective way,” said Dr. Carver Mead, an engineer at the California Institute of Technology in Pasadena not involved in the work.
Software to Hardware
The human brain is the ultimate computational wizard. With roughly 100 billion neurons densely packed into the size of a small football, the brain can deftly handle complex computation at lightning speed using very little energy.
AI experts have taken note. The past few years saw brain-inspired algorithms that can identify faces, falsify voices, and play a variety of games at—and often above—human capability.
But software is only part of the equation. Our current computers, with their transistors and binary digital systems, aren’t equipped to run these powerful algorithms.
That’s where neuromorphic computing comes in. The idea is simple: fabricate a computer chip that mimics the brain at the hardware level. Here, data is both processed and stored within the chip in an analog manner. Each artificial synapse can accumulate and integrate small bits of information from multiple sources and fire only when it reaches a threshold—much like its biological counterpart.
Experts believe the speed and efficiency gains will be enormous.
For one, the chips will no longer have to transfer data between the central processing unit (CPU) and storage blocks, which wastes both time and energy. For another, like biological neural networks, neuromorphic devices can support neurons that run millions of streams of parallel computation.
Optimism aside, reproducing the biological synapse in hardware form hasn’t been as easy as anticipated.
Neuromorphic chips exist in many forms, but often look like a nanoscale metal sandwich. The “bread” pieces are generally made of conductive plates surrounding a switching medium—a conductive material of sorts that acts like the gap in a biological synapse.
When a voltage is applied, as in the case of data input, ions move within the switching medium, which then creates conductive streams to stimulate the downstream plate. This change in conductivity mimics the way biological neurons change their “weight,” or the strength of connectivity between two adjacent neurons.
But so far, neuromorphic synapses have been rather unpredictable. According to Kim, that’s because the switching medium is often comprised of material that can’t channel ions to exact locations on the downstream plate.
“Once you apply some voltage to represent some data with your artificial neuron, you have to erase and be able to write it again in the exact same way,” explains Kim. “But in an amorphous solid, when you write again, the ions go in different directions because there are lots of defects.”
In his new study, Kim and colleagues swapped the jelly-like switching medium for silicon, a material with only a single line of defects that acts like a channel to guide ions.
The chip starts with a thin wafer of silicon etched with a honeycomb-like pattern. On top is a layer of silicon germanium—something often present in transistors—in the same pattern. This creates a funnel-like dislocation, a kind of Grand Canal that perfectly shuttles ions across the artificial synapse.
The researchers then made a neuromorphic chip containing these synapses and shot an electrical zap through them. Incredibly, the synapses’ response varied by only four percent—much higher than any neuromorphic device made with an amorphous switching medium.
In a computer simulation, the team built a multi-layer artificial neural network using parameters measured from their device. After tens of thousands of training examples, their neural network correctly recognized samples 95 percent of the time, just 2 percent lower than state-of-the-art software algorithms.
The upside? The neuromorphic chip requires much less space than the hardware that runs deep learning algorithms. Forget supercomputers—these chips could one day run complex computations right on our handheld devices.
A Magnetic Boost
Meanwhile, in Boulder, Colorado, Dr. Michael Schneider at the National Institute of Standards and Technology also realized that the standard switching medium had to go.
“There must be a better way to do this, because nature has figured out a better way to do this,” he says.
His solution? Nanoclusters of magnetic manganese.
Schneider’s chip contained two slices of superconducting electrodes made out of niobium, which channel electricity with no resistance. When researchers applied different magnetic fields to the synapse, they could control the alignment of the manganese “filling.”
The switch gave the chip a double boost. For one, by aligning the switching medium, the team could predict the ion flow and boost uniformity. For another, the magnetic manganese itself adds computational power. The chip can now encode data in both the level of electrical input and the direction of the magnetisms without bulking up the synapse.
It seriously worked. At one billion times per second, the chips fired several orders of magnitude faster than human neurons. Plus, the chips required just one ten-thousandth of the energy used by their biological counterparts, all the while synthesizing input from nine different sources in an analog manner.
The Road Ahead
These studies show that we may be nearing a benchmark where artificial synapses match—or even outperform—their human inspiration.
But to Dr. Steven Furber, an expert in neuromorphic computing, we still have a ways before the chips go mainstream.
Many of the special materials used in these chips require specific temperatures, he says. Magnetic manganese chips, for example, require temperatures around absolute zero to operate, meaning they come with the need for giant cooling tanks filled with liquid helium—obviously not practical for everyday use.
Another is scalability. Millions of synapses are necessary before a neuromorphic device can be used to tackle everyday problems such as facial recognition. So far, no deal.
But these problems may in fact be a driving force for the entire field. Intense competition could push teams into exploring different ideas and solutions to similar problems, much like these two studies.
If so, future chips may come in diverse flavors. Similar to our vast array of deep learning algorithms and operating systems, the computer chips of the future may also vary depending on specific requirements and needs.
It is worth developing as many different technological approaches as possible, says Furber, especially as neuroscientists increasingly understand what makes our biological synapses—the ultimate inspiration—so amazingly efficient.
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OptoForce Sensors Providing Industrial Robots with
a “Sense of Touch” to Advance Manufacturing Automation
Global efforts to expand the capabilities of industrial robots are on the rise, as the demand from manufacturing companies to strengthen their operations and improve performance grows.
Hungary-based OptoForce, with a North American office in Charlotte, North Carolina, is one company that continues to support organizations with new robotic capabilities, as evidenced by its several new applications released in 2017.
The company, a leading robotics technology provider of multi-axis force and torque sensors, delivers 6 degrees of freedom force and torque measurement for industrial automation, and provides sensors for most of the currently-used industrial robots.
It recently developed and brought to market three new applications for KUKA industrial robots.
The new applications are hand guiding, presence detection, and center pointing and will be utilized by both end users and systems integrators. Each application is summarized below and what they provide for KUKA robots, along with video demonstrations to show how they operate.
Photo By: www.optoforce.com
Hand Guiding: With OptoForce’s Hand Guiding application, KUKA robots can easily and smoothly move in an assigned direction and selected route. This video shows specifically how to program the robot for hand guiding.
Presence Detection: This application allows KUKA robots to detect the presence of a specific object and to find the object even if it has moved. Visit here to learn more about presence detection.
Center Pointing: With this application, the OptoForce sensor helps the KUKA robot find the center point of an object by providing the robot with a sense of touch. This solution also works with glossy metal objects where a vision system would not be able to define its position. This video shows in detail how the center pointing application works.
The company’s CEO explained how these applications help KUKA robots and industrial automation.
Photo By: www.optoforce.com
“OptoForce’s new applications for KUKA robots pave the way for substantial improvements in industrial automation for both end users and systems integrators,” said Ákos Dömötör, CEO of OptoForce. “Our 6-axis force/torque sensors are combined with highly functional hardware and a comprehensive software package, which include the pre-programmed industrial applications. Essentially, we’re adding a ‘sense of touch’ to KUKA robot arms, enabling these robots to have abilities similar to a human hand, and opening up numerous new capabilities in industrial automation.”
Along with these new applications recently released for KUKA robots, OptoForce sensors are also being used by various companies on numerous industrial robots and manufacturing automation projects around the world. Examples of other uses include: path recording, polishing plastic and metal, box insertion, placing pins in holes, stacking/destacking, palletizing, and metal part sanding.
Specifically, some of the projects current underway by companies include: a plastic parting line removal; an obstacle detection for a major car manufacturing company; and a center point insertion application for a car part supplier, where the task of the robot is to insert a mirror, completely centered, onto a side mirror housing.
For more information, visit www.optoforce.com.
This post was provided by: OptoForce
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