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#437236 Why We Need Mass Automation to ...
The scale of goods moving around the planet at any moment is staggering. Raw materials are dug up in one country, spun into parts and pieces in another, and assembled into products in a third. Crossing oceans and continents, they find their way to a local store or direct to your door.
Magically, a roll of toilet paper, power tool, or tube of toothpaste is there just when you need it.
Even more staggering is that this whole system, the global supply chain, works so well that it’s effectively invisible most of the time. Until now, that is. The pandemic has thrown a floodlight on the inner workings of this modern wonder—and it’s exposed massive vulnerabilities.
The e-commerce supply chain is an instructive example. As the world went into lockdown, and everything non-essential went online, demand for digital fulfillment skyrocketed.
Even under “normal” conditions, most e-commerce warehouses were struggling to meet demand. But Covid-19 has further strained the ability to cope with shifting supply, an unprecedented tidal wave of orders, and labor shortages. Local stores are running out of key products. Online grocers and e-commerce platforms are suspending some home deliveries, restricting online purchases of certain items, and limiting new customers. The whole system is being severely tested.
Why? Despite an abundance of 21st century technology, we’re stuck in the 20th century.
Today’s supply chain consists of fleets of ships, trucks, warehouses, and importantly, people scattered around the world. While there are some notable instances of advanced automation, the overwhelming majority of work is still manual, resembling a sort of human-powered bucket brigade, with people wandering around warehouses or standing alongside conveyor belts. Each package of diapers or bottle of detergent ordered by an online customer might be touched dozens of times by warehouse workers before finding its way into a box delivered to a home.
The pandemic has proven the critical need for innovation due to increased demand, concerns about the health and safety of workers, and traceability and safety of products and services.
At the 2020 World Economic Forum, there was much discussion about the ongoing societal transformation in which humans and machines work in tandem, automating and augmenting the way we get things done. At the time, pre-pandemic, debate trended toward skepticism and fear of job losses, with some even questioning the ethics and need for these technologies.
Now, we see things differently. To make the global supply chain more resilient to shocks like Covid-19, we must look to technology.
Perfecting the Global Supply Chain: The Massive ‘Matter Router’
Technology has faced and overcome similar challenges in the past.
World War II, for example, drove innovation in techniques for rapid production of many products on a large scale, including penicillin. We went from the availability of one dose of the drug in 1941, to four million sterile packages of the drug every month four years later.
Similarly, today’s companies, big and small, are looking to automation, robotics, and AI to meet the pandemic head on. These technologies are crucial to scaling the infrastructure that will fulfill most of the world’s e-commerce and food distribution needs.
You can think of this new infrastructure as a rapidly evolving “matter router” that will employ increasingly complex robotic systems to move products more freely and efficiently.
Robots powered by specialized AI software, for example, are already learning to adapt to changes in the environment, using the most recent advances in industrial robotics and machine learning. When customers suddenly need to order dramatically new items, these robots don’t need to stop or be reprogrammed. They can perform new tasks by learning from experience using low-cost camera systems and deep learning for visual and image recognition.
These more flexible robots can work around the clock, helping make facilities less sensitive to sudden changes in workforce and customer demand and strengthening the supply chain.
Today, e-commerce is roughly 12% of retail sales in the US and is expected to rise well beyond 25% within the decade, fueled by changes in buying habits. However, analysts have begun to consider whether the current crisis might cause permanent jumps in those numbers, as it has in the past (for instance with the SARS epidemic in China in 2003). Whatever happens, the larger supply chain will benefit from greater, more flexible automation, especially during global crises.
We must create what Hamza Mudassire of the University of Cambridge calls a “resilient ecosystem that links multiple buyers with multiple vendors, across a mesh of supply chains.” This ecosystem must be backed by robust, efficient, and scalable automation that uses robotics, autonomous vehicles, and the Internet of Things to help track the flow of goods through the supply chain.
The good news? We can accomplish this with technologies we have today.
Image credit: Guillaume Bolduc / Unsplash Continue reading
Posted in Human Robots
#436578 AI Just Discovered a New Antibiotic to ...
Penicillin, one of the greatest discoveries in the history of medicine, was a product of chance.
After returning from summer vacation in September 1928, bacteriologist Alexander Fleming found a colony of bacteria he’d left in his London lab had sprouted a fungus. Curiously, wherever the bacteria contacted the fungus, their cell walls broke down and they died. Fleming guessed the fungus was secreting something lethal to the bacteria—and the rest is history.
Fleming’s discovery of penicillin and its later isolation, synthesis, and scaling in the 1940s released a flood of antibiotic discoveries in the next few decades. Bacteria and fungi had been waging an ancient war against each other, and the weapons they’d evolved over eons turned out to be humanity’s best defense against bacterial infection and disease.
In recent decades, however, the flood of new antibiotics has slowed to a trickle.
Their development is uneconomical for drug companies, and the low-hanging fruit has long been picked. We’re now facing the emergence of strains of super bacteria resistant to one or more antibiotics and an aging arsenal to fight them with. Gone unchallenged, an estimated 700,000 deaths worldwide due to drug resistance could rise to as many as 10 million in 2050.
Increasingly, scientists warn the tide is turning, and we need a new strategy to keep pace with the remarkably quick and boundlessly creative tactics of bacterial evolution.
But where the golden age of antibiotics was sparked by serendipity, human intelligence, and natural molecular weapons, its sequel may lean on the uncanny eye of artificial intelligence to screen millions of compounds—and even design new ones—in search of the next penicillin.
Hal Discovers a Powerful Antibiotic
In a paper published this week in the journal, Cell, MIT researchers took a step in this direction. The team says their machine learning algorithm discovered a powerful new antibiotic.
Named for the AI in 2001: A Space Odyssey, the antibiotic, halicin, successfully wiped out dozens of bacterial strains, including some of the most dangerous drug-resistant bacteria on the World Health Organization’s most wanted list. The bacteria also failed to develop resistance to E. coli during a month of observation, in stark contrast to existing antibiotic ciprofloxacin.
“In terms of antibiotic discovery, this is absolutely a first,” Regina Barzilay, a senior author on the study and computer science professor at MIT, told The Guardian.
The algorithm that discovered halicin was trained on the molecular features of 2,500 compounds. Nearly half were FDA-approved drugs, and another 800 naturally occurring. The researchers specifically tuned the algorithm to look for molecules with antibiotic properties but whose structures would differ from existing antibiotics (as halicin’s does). Using another machine learning program, they screened the results for those likely to be safe for humans.
Early study suggests halicin attacks the bacteria’s cell membranes, disrupting their ability to produce energy. Protecting the cell membrane from halicin might take more than one or two genetic mutations, which could account for its impressive ability to prevent resistance.
“I think this is one of the more powerful antibiotics that has been discovered to date,” James Collins, an MIT professor of bioengineering and senior author told The Guardian. “It has remarkable activity against a broad range of antibiotic-resistant pathogens.”
Beyond tests in petri-dish bacterial colonies, the team also tested halicin in mice. The antibiotic cleared up infections of a strain of bacteria resistant to all known antibiotics in a day. The team plans further study in partnership with a pharmaceutical company or nonprofit, and they hope to eventually prove it safe and effective for use in humans.
This last bit remains the trickiest step, given the cost of getting a new drug approved. But Collins hopes algorithms like theirs will help. “We could dramatically reduce the cost required to get through clinical trials,” he told the Financial Times.
A Universe of Drugs Awaits
The bigger story may be what happens next.
How many novel antibiotics await discovery, and how far can AI screening take us? The initial 6,000 compounds scanned by Barzilay and Collins’s team is a drop in the bucket.
They’ve already begun digging deeper by setting the algorithm loose on 100 million molecules from an online library of 1.5 billion compounds called the ZINC15 database. This first search took three days and turned up 23 more candidates that, like halicin, differ structurally from existing antibiotics and may be safe for humans. Two of these—which the team will study further—appear to be especially powerful.
Even more ambitiously, Barzilay hopes the approach can find or even design novel antibiotics that kill bad bacteria with alacrity while sparing the good guys. In this way, a round of antibiotics would cure whatever ails you without taking out your whole gut microbiome in the process.
All this is part of a larger movement to use machine learning algorithms in the long, expensive process of drug discovery. Other players in the area are also training AI on the vast possibility space of drug-like compounds. Last fall, one of the leaders in the area, Insilico, was challenged by a partner to see just how fast their method could do the job. The company turned out a new a proof-of-concept drug candidate in only 46 days.
The field is still developing, however, and it has yet to be seen exactly how valuable these approaches will be in practice. Barzilay is optimistic though.
“There is still a question of whether machine-learning tools are really doing something intelligent in healthcare, and how we can develop them to be workhorses in the pharmaceuticals industry,” she said. “This shows how far you can adapt this tool.”
Image Credit: Halicin (top row) prevented the development of antibiotic resistance in E. coli, while ciprofloxacin (bottom row) did not. Collins Lab at MIT Continue reading
Posted in Human Robots
#436234 Robot Gift Guide 2019
Welcome to the eighth edition of IEEE Spectrum’s Robot Gift Guide!
This year we’re featuring 15 robotic products that we think will make fantastic holiday gifts. As always, we tried to include a broad range of robot types and prices, focusing mostly on items released this year. (A reminder: While we provide links to places where you can buy these items, we’re not endorsing any in particular, and a little bit of research may result in better deals.)
If you need even more robot gift ideas, take a look at our past guides: 2018, 2017, 2016, 2015, 2014, 2013, and 2012. Some of those robots are still great choices and might be way cheaper now than when we first posted about them. And if you have suggestions that you’d like to share, post a comment below to help the rest of us find the perfect robot gift.
Skydio 2
Image: Skydio
What makes robots so compelling is their autonomy, and the Skydio 2 is one of the most autonomous robots we’ve ever seen. It uses an array of cameras to map its environment and avoid obstacles in real-time, making flight safe and effortless and enabling the kinds of shots that would be impossible otherwise. Seriously, this thing is magical, and it’s amazing that you can actually buy one.
$1,000
Skydio
UBTECH Jimu MeeBot 2
Image: UBTECH
The Jimu MeeBot 2.0 from UBTECH is a STEM education robot designed to be easy to build and program. It includes six servo motors, a color sensor, and LED lights. An app for iPhone or iPad provides step-by-step 3D instructions, and helps you code different behaviors for the robot. It’s available exclusively from Apple.
$130
Apple
iRobot Roomba s9+
Image: iRobot
We know that $1,400 is a crazy amount of money to spend on a robot vacuum, but the Roomba s9+ is a crazy robot vacuum. As if all of its sensors and mapping intelligence wasn’t enough, it empties itself, which means that you can have your floors vacuumed every single day for a month and you don’t have to even think about it. This is what home robots are supposed to be.
$1,400
iRobot
PFF Gita
Photo: Piaggio Fast Forward
Nobody likes carrying things, which is why Gita is perfect for everyone with an extra $3,000 lying around. Developed by Piaggio Fast Forward, this autonomous robot will follow you around with a cargo hold full of your most important stuff, and do it in a way guaranteed to attract as much attention as possible.
$3,250
Gita
DJI Mavic Mini
Photo: DJI
It’s tiny, it’s cheap, and it takes good pictures—what more could you ask for from a drone? And for $400, this is an excellent drone to get if you’re on a budget and comfortable with manual flight. Keep in mind that while the Mavic Mini is small enough that you don’t need to register it with the FAA, you do still need to follow all the same rules and regulations.
$400
DJI
LEGO Star Wars Droid Commander
Image: LEGO
Designed for kids ages 8+, this LEGO set includes more than 1,000 pieces, enough to build three different droids: R2-D2, Gonk Droid, and Mouse Droid. Using a Bluetooth-controlled robotic brick called Move Hub, which connects to the LEGO BOOST Star Wars app, kids can change how the robots behave and solve challenges, learning basic robotics and coding skills.
$200
LEGO
Sony Aibo
Photo: Sony
Robot pets don’t get much more sophisticated (or expensive) than Sony’s Aibo. Strictly speaking, it’s one of the most complex consumer robots you can buy, and Sony continues to add to Aibo’s software. Recent new features include user programmability, and the ability to “feed” it.
$2,900 (free aibone and paw pads until 12/29/2019)
Sony
Neato Botvac D4 Connected
Photo: Neato
The Neato Botvac D4 may not have all of the features of its fancier and more expensive siblings, but it does have the features that you probably care the most about: The ability to make maps of its environment for intelligent cleaning (using lasers!), along with user-defined no-go lines that keep it where you want it. And it cleans quite well, too.
$530 $350 (sale)
Neato Robotics
Cubelets Curiosity Set
Photo: Modular Robotics
Cubelets are magnetic blocks that you can snap together to make an endless variety of robots with no programming and no wires. The newest set, called Curiosity, is designed for kids ages 4+ and comes with 10 robotic cubes. These include light and distance sensors, motors, and a Bluetooth module, which connects the robot constructions to the Cubelets app.
$250
Modular Robotics
Tertill
Photo: Franklin Robotics
Tertill does one simple job: It weeds your garden. It’s waterproof, dirt proof, solar powered, and fully autonomous, meaning that you can leave it out in your garden all summer and just enjoy eating your plants rather than taking care of them.
$350
Tertill
iRobot Root
Photo: iRobot
Root was originally developed by Harvard University as a tool to help kids progressively learn to code. iRobot has taken over Root and is now supporting the curriculum, which starts for kids before they even know how to read and should keep them busy for years afterwards.
$200
iRobot
LOVOT
Image: Lovot
Let’s be honest: Nobody is really quite sure what LOVOT is. We can all agree that it’s kinda cute, though. And kinda weird. But cute. Created by Japanese robotics startup Groove X, LOVOT does have a whole bunch of tech packed into its bizarre little body and it will do its best to get you to love it.
$2,750 (¥300,000)
LOVOT
Sphero RVR
Photo: Sphero
RVR is a rugged, versatile, easy to program mobile robot. It’s a development platform designed to be a bridge between educational robots like Sphero and more sophisticated and expensive systems like Misty. It’s mostly affordable, very expandable, and comes from a company with a lot of experience making robots.
$250
Sphero
“How to Train Your Robot”
Image: Lawrence Hall of Science
Aimed at 4th and 5th graders, “How to Train Your Robot,” written by Blooma Goldberg, Ken Goldberg, and Ashley Chase, and illustrated by Dave Clegg, is a perfect introduction to robotics for kids who want to get started with designing and building robots. But the book isn’t just for beginners: It’s also a fun, inspiring read for kids who are already into robotics and want to go further—it even introduces concepts like computer simulations and deep learning. You can download a free digital copy or request hardcopies here.
Free
UC Berkeley
MIT Mini Cheetah
Photo: MIT
Yes, Boston Dynamics’ Spot, now available for lease, is probably the world’s most famous quadruped, but MIT is starting to pump out Mini Cheetahs en masse for researchers, and while we’re not exactly sure how you’d manage to get one of these things short of stealing one directly for MIT, a Mini Cheetah is our fantasy robotics gift this year. Mini Cheetah looks like a ton of fun—it’s portable, highly dynamic, super rugged, and easy to control. We want one!
Price N/A
MIT Biomimetic Robotics Lab
For more tech gift ideas, see also IEEE Spectrum’s annual Gift Guide. Continue reading
Posted in Human Robots