Tag Archives: platform
The iCub platform was developed for the EU project RobotCub, and the humanoid is able to see and hear, and it has the sense of proprioception (Wikipedia: “the sense of the relative position of one’s own parts of the body … Continue reading →
The longevity field is bustling but still fragmented, and the “silver tsunami” is coming.
That is the takeaway of The Science of Longevity, the behemoth first volume of a four-part series offering a bird’s-eye view of the longevity industry in 2017. The report, a joint production of the Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International, synthesizes the growing array of academic and industry ventures related to aging, healthspan, and everything in between.
This is huge, not only in scale but also in ambition. The report, totally worth a read here, will be followed by four additional volumes in 2018, covering topics ranging from the business side of longevity ventures to financial systems to potential tensions between life extension and religion.
And that’s just the first step. The team hopes to publish updated versions of the report annually, giving scientists, investors, and regulatory agencies an easy way to keep their finger on the longevity pulse.
“In 2018, ‘aging’ remains an unnamed adversary in an undeclared war. For all intents and purposes it is mere abstraction in the eyes of regulatory authorities worldwide,” the authors write.
That needs to change.
People often arrive at the field of aging from disparate areas with wildly diverse opinions and strengths. The report compiles these individual efforts at cracking aging into a systematic resource—a “periodic table” for longevity that clearly lays out emerging trends and promising interventions.
The ultimate goal? A global framework serving as a road map to guide the burgeoning industry. With such a framework in hand, academics and industry alike are finally poised to petition the kind of large-scale investments and regulatory changes needed to tackle aging with a unified front.
Infographic depicting many of the key research hubs and non-profits within the field of geroscience.
Image Credit: Longevity.International
The Aging Globe
The global population is rapidly aging. And our medical and social systems aren’t ready to handle this oncoming “silver tsunami.”
Take the medical field. Many age-related diseases such as Alzheimer’s lack effective treatment options. Others, including high blood pressure, stroke, lung or heart problems, require continuous medication and monitoring, placing enormous strain on medical resources.
What’s more, because disease risk rises exponentially with age, medical care for the elderly becomes a game of whack-a-mole: curing any individual disease such as cancer only increases healthy lifespan by two to three years before another one hits.
That’s why in recent years there’s been increasing support for turning the focus to the root of the problem: aging. Rather than tackling individual diseases, geroscience aims to add healthy years to our lifespan—extending “healthspan,” so to speak.
Despite this relative consensus, the field still faces a roadblock. The US FDA does not yet recognize aging as a bona fide disease. Without such a designation, scientists are banned from testing potential interventions for aging in clinical trials (that said, many have used alternate measures such as age-related biomarkers or Alzheimer’s symptoms as a proxy).
Luckily, the FDA’s stance is set to change. The promising anti-aging drug metformin, for example, is already in clinical trials, examining its effect on a variety of age-related symptoms and diseases. This report, and others to follow, may help push progress along.
“It is critical for investors, policymakers, scientists, NGOs, and influential entities to prioritize the amelioration of the geriatric world scenario and recognize aging as a critical matter of global economic security,” the authors say.
The causes of aging are complex, stubborn, and not all clear.
But the report lays out two main streams of intervention with already promising results.
The first is to understand the root causes of aging and stop them before damage accumulates. It’s like meddling with cogs and other inner workings of a clock to slow it down, the authors say.
The report lays out several treatments to keep an eye on.
Geroprotective drugs is a big one. Often repurposed from drugs already on the market, these traditional small molecule drugs target a wide variety of metabolic pathways that play a role in aging. Think anti-oxidants, anti-inflammatory, and drugs that mimic caloric restriction, a proven way to extend healthspan in animal models.
More exciting are the emerging technologies. One is nanotechnology. Nanoparticles of carbon, “bucky-balls,” for example, have already been shown to fight viral infections and dangerous ion particles, as well as stimulate the immune system and extend lifespan in mice (though others question the validity of the results).
Blood is another promising, if surprising, fountain of youth: recent studies found that molecules in the blood of the young rejuvenate the heart, brain, and muscles of aged rodents, though many of these findings have yet to be replicated.
The second approach is repair and maintenance.
Rather than meddling with inner clockwork, here we force back the hands of a clock to set it back. The main example? Stem cell therapy.
This type of approach would especially benefit the brain, which harbors small, scattered numbers of stem cells that deplete with age. For neurodegenerative diseases like Alzheimer’s, in which neurons progressively die off, stem cell therapy could in theory replace those lost cells and mend those broken circuits.
Once a blue-sky idea, the discovery of induced pluripotent stem cells (iPSCs), where scientists can turn skin and other mature cells back into a stem-like state, hugely propelled the field into near reality. But to date, stem cells haven’t been widely adopted in clinics.
It’s “a toolkit of highly innovative, highly invasive technologies with clinical trials still a great many years off,” the authors say.
But there is a silver lining. The boom in 3D tissue printing offers an alternative approach to stem cells in replacing aging organs. Recent investment from the Methuselah Foundation and other institutions suggests interest remains high despite still being a ways from mainstream use.
A Disruptive Future
“We are finally beginning to see an industry emerge from mankind’s attempts to make sense of the biological chaos,” the authors conclude.
Looking through the trends, they identified several technologies rapidly gaining steam.
One is artificial intelligence, which is already used to bolster drug discovery. Machine learning may also help identify new longevity genes or bring personalized medicine to the clinic based on a patient’s records or biomarkers.
Another is senolytics, a class of drugs that kill off “zombie cells.” Over 10 prospective candidates are already in the pipeline, with some expected to enter the market in less than a decade, the authors say.
Finally, there’s the big gun—gene therapy. The treatment, unlike others mentioned, can directly target the root of any pathology. With a snip (or a swap), genetic tools can turn off damaging genes or switch on ones that promote a youthful profile. It is the most preventative technology at our disposal.
There have already been some success stories in animal models. Using gene therapy, rodents given a boost in telomerase activity, which lengthens the protective caps of DNA strands, live healthier for longer.
“Although it is the prospect farthest from widespread implementation, it may ultimately prove the most influential,” the authors say.
Ultimately, can we stop the silver tsunami before it strikes?
Perhaps not, the authors say. But we do have defenses: the technologies outlined in the report, though still immature, could one day stop the oncoming tidal wave in its tracks.
Now we just have to bring them out of the lab and into the real world. To push the transition along, the team launched Longevity.International, an online meeting ground that unites various stakeholders in the industry.
By providing scientists, entrepreneurs, investors, and policy-makers a platform for learning and discussion, the authors say, we may finally generate enough drive to implement our defenses against aging. The war has begun.
Read the report in full here, and watch out for others coming soon here. The second part of the report profiles 650 (!!!) longevity-focused research hubs, non-profits, scientists, conferences, and literature. It’s an enormously helpful resource—totally worth keeping it in your back pocket for future reference.
Image Credit: Worraket / Shutterstock.com Continue reading →
At Singularity University, we are unleashing a generation of women who are smashing through barriers and starting some of the most ambitious technology companies on the planet.
Singularity University was founded in 2008 to empower leaders to use exponential technologies to solve our world’s biggest challenges. Our flagship program, the Global Solutions Program, has historically brought 80 entrepreneurs from around the world to Silicon Valley for 10 weeks to learn about exponential technologies and create moonshot startups that improve the lives of a billion people within a decade.
After nearly 10 years of running this program, we can say that about 70 percent of our successful startups have been founded or co-founded by female entrepreneurs (see below for inspiring examples of their work). This is in sharp contrast to the typical 10–20 percent of venture-backed tech companies that have a female founder, as reported by TechCrunch.
How are we so dramatically changing the game? While 100 percent of the credit goes to these courageous women, as both an alumna of the Global Solutions Program and our current vice chair of Global Grand Challenges, I want to share my reflections on what has worked.
At the most basic level, it is essential to deeply believe in the inherent worth, intellectual genius, and profound entrepreneurial caliber of women. While this may seem obvious, this is not the way our world currently thinks—we live in a world that sees women’s ideas, contributions, work, and existence as inherently less valuable than men’s.
For example, a 2017 Harvard Business Review article noted that even when women engage in the same behaviors and work as men, their work is considered less valuable simply because a woman did the job. An additional 2017 Harvard Business Review article showed that venture capitalists are significantly less likely to invest in female entrepreneurs and are more likely to ask men questions about the potential success of their companies while grilling women about the potential downfalls of their companies.
This doubt and lack of recognition of the genius and caliber of women is also why women are still paid less than men for completing identical work. Further, it’s why women’s work often gets buried in “number two” support roles of men in leadership roles and why women are expected to take on second shifts at home managing tedious household chores in addition to their careers. I would also argue these views as well as the rampant sexual harassment, assault, and violence against women that exists today stems from stubborn, historical, patriarchal views of women as living for the benefit of men, rather than for their own sovereignty and inherent value.
As with any other business, Singularity University has not been immune to these biases but is resolutely focused on helping women achieve intellectual genius and global entrepreneurial caliber by harnessing powerful exponential technologies.
We create an environment where women can physically and intellectually thrive free of harassment to reach their full potential, and we are building a broader ecosystem of alumni and partners around the world who not only support our female entrepreneurs throughout their entrepreneurial journeys, but who are also sparking and leading systemic change in their own countries and communities.
Respecting the Intellectual Genius and Entrepreneurial Caliber of Women
The entrepreneurial legends of our time—Steve Jobs, Elon Musk, Mark Zuckerberg, Bill Gates, Jeff Bezos, Larry Page, Sergey Brin—are men who have all built their empires using exponential technologies. Exponential technologies helped these men succeed faster and with greater impact due to Moore’s Law and the Law of Accelerating Returns which states that any digital technology (such as computing, software, artificial intelligence, robotics, quantum computing, biotechnology, nanotechnology, etc.) will become more sophisticated while dramatically falling in price, enabling rapid scaling.
Knowing this, an entrepreneur can plot her way to an ambitious global solution over time, releasing new applications just as the technology and market are ready. Furthermore, these rapidly advancing technologies often converge to create new tools and opportunities for innovators to come up with novel solutions to challenges that were previously impossible to solve in the past.
For various reasons, women have not pursued exponential technologies as aggressively as men (or were prevented or discouraged from doing so).
While more women are founding firms at a higher rate than ever in wealthy countries like the United States, the majority are small businesses in linear industries that have been around for hundreds of years, such as social assistance, health, education, administrative, or consulting services. In lower-income countries, international aid agencies and nonprofits often encourage women to pursue careers in traditional handicrafts, micro-enterprise, and micro-finance. While these jobs have historically helped women escape poverty and gain financial independence, they have done little to help women realize the enormous power, influence, wealth, and ability to transform the world for the better that comes from building companies, nonprofits, and solutions grounded in exponential technologies.
We need women to be working with exponential technologies today in order to be powerful leaders in the future.
Participants who enroll in our Global Solutions Program spend the first few weeks of the program learning about exponential technologies from the world’s experts and the final weeks launching new companies or nonprofits in their area of interest. We require that women (as well as men) utilize exponential technologies as a condition of the program.
In this sense, at Singularity University women start their endeavors with all of us believing and behaving in a way that assumes they can achieve global impact at the level of our world’s most legendary entrepreneurs.
Creating an Environment Where Woman Can Thrive
While challenging women to embrace exponential technologies is essential, it is also important to create an environment where women can thrive. In particular, this means ensuring women feel at home on our campus by ensuring gender diversity, aggressively addressing sexual harassment, and flipping the traditional culture from one that penalizes women, to one that values and supports them.
While women were initially only a small minority of our Global Solutions Program, in 2014, we achieved around 50% female attendance—a statistic that has since held over the years.
This is not due to a quota—every year we turn away extremely qualified women from our program (and are working on reformulating the program to allow more people to participate in the future.) While part of our recruiting success is due to the efforts of our marketing team, we also benefited from the efforts of some of our early female founders, staff, faculty, and alumnae including Susan Fonseca, Emeline Paat-Dahlstrom, Kathryn Myronuk, Lajuanda Asemota, Chiara Giovenzana, and Barbara Silva Tronseca.
As early champions of Singularity University these women not only launched diversity initiatives and personally reached out to women, but were crucial role models holding leadership roles in our community. In addition, Fonseca and Silva also both created multiple organizations and initiatives outside of (or in conjunction with) the university that produced additional pipelines of female candidates. In particular, Fonseca founded Women@TheFrontier as well as other organizations focusing on women, technology and innovation, and Silva founded BestInnovation (a woman’s accelerator in Latin America), as well as led Singularity University’s Chilean Chapter and founded the first SingularityU Summit in Latin America.
These women’s efforts in globally scaling Singularity University have been critical in ensuring woman around the world now see Singularity University as a place where they can lead and shape the future.
Also, thanks to Google (Alphabet) and many of our alumni and partners, we were able to provide full scholarships to any woman (or man) to attend our program regardless of their economic status. Google committed significant funding for full scholarships while our partners around the world also hosted numerous Global Impact Competitions, where entrepreneurs pitched their solutions to their local communities with the winners earning a full scholarship funded by our partners to attend the Global Solution Program as their prize.
Google and our partners’ support helped individuals attend our program and created a wider buzz around exponential technology and social change around the world in local communities. It led to the founding of 110 SU chapters in 55 countries.
Another vital aspect of our work in supporting women has been trying to create a harassment-free environment. Throughout the Silicon Valley, more than 60% of women convey that while they are trying to build their companies or get their work done, they are also dealing with physical and sexual harassment while being demeaned and excluded in other ways in the workplace. We have taken actions to educate and train our staff on how to deal with situations should they occur. All staff receives training on harassment when they join Singularity University, and all Global Solutions Program participants attend mandatory trainings on sexual harassment when they first arrive on campus. We also have male and female wellness counselors available that can offer support to both individuals and teams of entrepreneurs throughout the entire program.
While at a minimum our campus must be physically safe for women, we also strive to create a culture that values women and supports them in the additional challenges and expectations they face. For example, one of our 2016 female participants, Van Duesterberg, was pregnant during the program and said that instead of having people doubt her commitment to her startup or make her prove she could handle having a child and running a start-up at the same time, people went out of their way to help her.
“I was the epitome of a person not supposed to be doing a startup,” she said. “I was pregnant and would need to take care of my child. But Singularity University was supportive and encouraging. They made me feel super-included and that it was possible to do both. I continue to come back to campus even though the program is over because the network welcomes me and supports me rather than shuts me out because of my physical limitations. Rather than making me feel I had to prove myself, everyone just understood me and supported me, whether it was bringing me healthy food or recommending funders.”
Another strength that we have in supporting women is that after the Global Solutions Program, entrepreneurs have access to a much larger ecosystem.
Many entrepreneurs partake in SU Ventures, which can provide further support to startups as they develop, and we now have a larger community of over 200,000 people in almost every country. These members have often attended other Singularity University programs, events and are committed to our vision of the future. These women and men consist of business executives, Fortune 500 companies, investors, nonprofit and government leaders, technologists, members of the media, and other movers and shakers in the world. They have made introductions for our founders, collaborated with them on business ventures, invested in them and showcased their work at high profile events around the world.
Building for the Future
While our Global Solutions Program is making great strides in supporting female entrepreneurs, there is always more work to do. We are now focused on achieving the same degree of female participation across all of our programs and actively working to recruit and feature more female faculty and speakers on stage. As our community grows and scales around the world, we are also intent at how to best uphold our values and policies around sexual harassment across diverse locations and cultures. And like all businesses everywhere, we are focused on recruiting more women to serve at senior leadership levels within SU. As we make our way forward, we hope that you will join us in boldly leading this change and recognizing the genius and power of female entrepreneurs.
Meet Some of Our Female Moonshots
While we have many remarkable female entrepreneurs in the Singularity University community, the list below features a few of the women who have founded or co-founded companies at the Global Solutions Program that have launched new industries and are on their way to changing the way our world works for millions if not billions of people.
Jessica Scorpio co-founded Getaround in 2009. Getaround was one of the first car-sharing service platforms allowing anyone to rent out their car using a smartphone app. GetAround was a revolutionary idea in 2009, not only because smartphones and apps were still in their infancy, but because it was unthinkable that a technology startup could disrupt the major entrenched car, transport, and logistics companies. Scorpio’s early insights and pioneering entrepreneurial work brought to life new ways that humans relate to car sharing and the future self-driving car industry. Scorpio and Getaround have won numerous awards, and Getaround now serves over 200,000 members.
Paola Santana co-founded Matternet in 2011, which pioneered the commercial drone transport industry. In 2011, only military, hobbyists or the film industry used drones. Matternet demonstrated that drones could be used for commercial transport in short point-to-point deliveries for high-value goods laying the groundwork for drone transport around the world as well as some of the early thinking behind the future flying car industry. Santana was also instrumental in shaping regulations for the use of commercial drones around the world, making the industry possible.
Sara Naseri co-founded Qurasense in 2014, a life sciences start-up that analyzes women’s health through menstrual blood allowing women to track their health every month. Naseri is shifting our understanding of women’s menstrual blood as a waste product and something “not to be talked about,” to a rich, non-invasive, abundant source of information about women’s health.
Abi Ramanan co-founded ImpactVision in 2015, a software company that rapidly analyzes the quality and characteristics of food through hyperspectral images. Her long-term vision is to digitize food supply chains to reduce waste and fraud, given that one-third of all food is currently wasted before it reaches our plates. Ramanan is also helping the world understand that hyperspectral technology can be used in many industries to help us “see the unseen” and augment our ability to sense and understand what is happening around us in a much more sophisticated way.
Anita Schjøll Brede and Maria Ritola co-founded Iris AI in 2015, an artificial intelligence company that is building an AI research assistant that drastically improves the efficiency of R&D research and breaks down silos between different industries. Their long-term vision is for Iris AI to become smart enough that she will become a scientist herself. Fast Company named Iris AI one of the 10 most innovative artificial intelligence companies for 2017.
Hla Hla Win co-founded 360ed in 2016, a startup that conducts teacher training and student education through virtual reality and augmented reality in Myanmar. They have already connected teachers from 128 private schools in Myanmar with schools teaching 21st-century skills in Silicon Valley and around the world. Their moonshot is to build a platform where any teacher in the world can share best practices in teachers’ training. As they succeed, millions of children in some of the poorest parts of the world will have access to a 21st-century education.
Min FitzGerald and Van Duesterberg cofounded Nutrigene in 2017, a startup that ships freshly formulated, tailor-made supplement elixirs directly to consumers. Their long-term vision is to help people optimize their health using actionable data insights, so people can take a guided, tailored approaching to thriving into longevity.
Anna Skaya co-founded Basepaws in 2016, which created the first genetic test for cats and is building a community of citizen scientist pet owners. They are creating personalized pet products such as supplements, therapeutics, treats, and toys while also developing a database of genetic data for future research that will help both humans and pets over the long term.
Olivia Ramos co-founded Deep Blocks in 2016, a startup using artificial intelligence to integrate and streamline the processes of architecture, pre-construction, and real estate. As digital technologies, artificial intelligence, and robotics advance, it no longer makes sense for these industries to exist separately. Ramos recognized the tremendous value and efficiency that it is now possible to unlock with exponential technologies and creating an integrated industry in the future.
Please also visit our website to learn more about other female entrepreneurs, staff and faculty who are pioneering the future through exponential technologies. Continue reading →
They say size isn’t everything, but when it comes to delta robots it seems like it’s pretty important.
The speed and precision of these machines sees them employed in delicate pick-and-place tasks in all kinds of factories, as well as to control 3D printer heads. But Harvard researchers have found that scaling them down to millimeter scale makes them even faster and more precise, opening up applications in everything from microsurgery to manipulating tiny objects like circuit board components or even living cells.
Unlike the industrial robots you’re probably more familiar with, delta robots consist of three individually controlled arms supporting a platform. Different combinations of movements can move the platform in three directions, and a variety of tools can be attached to this platform.
The benefit of this design is that unlike a typical robotic arm, all the motors are housed at the base rather than at the joints, which reduces their mechanical complexity, but also—importantly—the weight of the arms. That means they can move and accelerate faster and with greater precision.
It’s been known for a while that the physics of these robots means the smaller you can make them, the more pronounced these advantages become, but scientists had struggled to build them at scales below tens of centimeters.
In a recent paper in the journal Science Robotics, the researchers describe how they used an origami-inspired micro-fabrication approach that relies on folding flat sheets of composite materials to create a robot measuring just 15 millimeters by 15 millimeters by 20 millimeters.
The robot dubbed “milliDelta” features joints that rely on a flexible polymer core to bend—a simplified version of the more complicated joints found in large-scale delta robots. The machine was powered by three piezoelectric actuators, which flex when a voltage is applied, and could perform movements at frequencies 15 to 20 times higher than current delta robots, with precisions down to roughly 5 micrometers.
One potential use for the device is to cancel out surgeons’ hand tremors as they carry out delicate microsurgery procedures, such as operations on the eye’s retina. The researchers actually investigated this application in their paper. They got volunteers to hold a toothpick and measured the movement of the tip to map natural hand tremors. They fed this data to the milliDelta, which was able to match the movements and therefore cancel them out.
In an email to Singularity Hub, the researchers said that adding the robot to the end of a surgical tool could make it possible to stabilize needles or scalpels, though this would require some design optimization. For a start, the base would have to be redesigned to fit on a surgical tool, and sensors would have to be added to the robot to allow it to measure tremors in real time.
Another promising application for the device would be placing components on circuit boards at very high speeds, which could prove valuable in electronics manufacturing. The researchers even think the device’s precision means it could be used for manipulating living cells in research and clinical laboratories.
The researchers even said it would be feasible to integrate the devices onto microrobots to give them similarly impressive manipulation capabilities, though that would require considerable work to overcome control and sensing challenges.
Image Credit: Wyss institute / Harvard Continue reading →
From the creators of Sphero, this robot is designed to allow non-robotics programmers to create useful applications Continue reading →