Tag Archives: patients

#436437 Why AI Will Be the Best Tool for ...

Dmitry Kaminskiy speaks as though he were trying to unload everything he knows about the science and economics of longevity—from senolytics research that seeks to stop aging cells from spewing inflammatory proteins and other molecules to the trillion-dollar life extension industry that he and his colleagues are trying to foster—in one sitting.

At the heart of the discussion with Singularity Hub is the idea that artificial intelligence will be the engine that drives breakthroughs in how we approach healthcare and healthy aging—a concept with little traction even just five years ago.

“At that time, it was considered too futuristic that artificial intelligence and data science … might be more accurate compared to any hypothesis of human doctors,” said Kaminskiy, co-founder and managing partner at Deep Knowledge Ventures, an investment firm that is betting big on AI and longevity.

How times have changed. Artificial intelligence in healthcare is attracting more investments and deals than just about any sector of the economy, according to data research firm CB Insights. In the most recent third quarter, AI healthcare startups raised nearly $1.6 billion, buoyed by a $550 million mega-round from London-based Babylon Health, which uses AI to collect data from patients, analyze the information, find comparable matches, then make recommendations.

Even without the big bump from Babylon Health, AI healthcare startups raised more than $1 billion last quarter, including two companies focused on longevity therapeutics: Juvenescence and Insilico Medicine.

The latter has risen to prominence for its novel use of reinforcement learning and general adversarial networks (GANs) to accelerate the drug discovery process. Insilico Medicine recently published a seminal paper that demonstrated how such an AI system could generate a drug candidate in just 46 days. Co-founder and CEO Alex Zhavoronkov said he believes there is no greater goal in healthcare today—or, really, any venture—than extending the healthy years of the human lifespan.

“I don’t think that there is anything more important than that,” he told Singularity Hub, explaining that an unhealthy society is detrimental to a healthy economy. “I think that it’s very, very important to extend healthy, productive lifespan just to fix the economy.”

An Aging Crisis
The surge of interest in longevity is coming at a time when life expectancy in the US is actually dropping, despite the fact that we spend more money on healthcare than any other nation.

A new paper in the Journal of the American Medical Association found that after six decades of gains, life expectancy for Americans has decreased since 2014, particularly among young and middle-aged adults. While some of the causes are societal, such as drug overdoses and suicide, others are health-related.

While average life expectancy in the US is 78, Kaminskiy noted that healthy life expectancy is about ten years less.

To Zhavoronkov’s point about the economy (a topic of great interest to Kaminskiy as well), the US spent $1.1 trillion on chronic diseases in 2016, according to a report from the Milken Institute, with diabetes, cardiovascular conditions, and Alzheimer’s among the most costly expenses to the healthcare system. When the indirect costs of lost economic productivity are included, the total price tag of chronic diseases in the US is $3.7 trillion, nearly 20 percent of GDP.

“So this is the major negative feedback on the national economy and creating a lot of negative social [and] financial issues,” Kaminskiy said.

Investing in Longevity
That has convinced Kaminskiy that an economy focused on extending healthy human lifespans—including the financial instruments and institutions required to support a long-lived population—is the best way forward.

He has co-authored a book on the topic with Margaretta Colangelo, another managing partner at Deep Knowledge Ventures, which has launched a specialized investment fund, Longevity.Capital, focused on the longevity industry. Kaminskiy estimates that there are now about 20 such investment funds dedicated to funding life extension companies.

In November at the inaugural AI for Longevity Summit in London, he and his collaborators also introduced the Longevity AI Consortium, an academic-industry initiative at King’s College London. Eventually, the research center will include an AI Longevity Accelerator program to serve as a bridge between startups and UK investors.

Deep Knowledge Ventures has committed about £7 million ($9 million) over the next three years to the accelerator program, as well as establishing similar consortiums in other regions of the world, according to Franco Cortese, a partner at Longevity.Capital and director of the Aging Analytics Agency, which has produced a series of reports on longevity.

A Cure for What Ages You
One of the most recent is an overview of Biomarkers for Longevity. A biomarker, in the case of longevity, is a measurable component of health that can indicate a disease state or a more general decline in health associated with aging. Examples range from something as simple as BMI as an indicator of obesity, which is associated with a number of chronic diseases, to sophisticated measurements of telomeres, the protective ends of chromosomes that shorten as we age.

While some researchers are working on moonshot therapies to reverse or slow aging—with a few even arguing we could expand human life on the order of centuries—Kaminskiy said he believes understanding biomarkers of aging could make more radical interventions unnecessary.

In this vision of healthcare, people would be able to monitor their health 24-7, with sensors attuned to various biomarkers that could indicate the onset of everything from the flu to diabetes. AI would be instrumental in not just ingesting the billions of data points required to develop such a system, but also what therapies, treatments, or micro-doses of a drug or supplement would be required to maintain homeostasis.

“Consider it like Tesla with many, many detectors, analyzing the behavior of the car in real time, and a cloud computing system monitoring those signals in real time with high frequency,” Kaminskiy explained. “So the same shall be applied for humans.”

And only sophisticated algorithms, Kaminskiy argued, can make longevity healthcare work on a mass scale but at the individual level. Precision medicine becomes preventive medicine. Healthcare truly becomes a system to support health rather than a way to fight disease.

Image Credit: Photo by h heyerlein on Unsplash Continue reading

Posted in Human Robots

#435765 The Four Converging Technologies Giving ...

How each of us sees the world is about to change dramatically.

For all of human history, the experience of looking at the world was roughly the same for everyone. But boundaries between the digital and physical are beginning to fade.

The world around us is gaining layer upon layer of digitized, virtually overlaid information—making it rich, meaningful, and interactive. As a result, our respective experiences of the same environment are becoming vastly different, personalized to our goals, dreams, and desires.

Welcome to Web 3.0, or the Spatial Web. In version 1.0, static documents and read-only interactions limited the internet to one-way exchanges. Web 2.0 provided quite an upgrade, introducing multimedia content, interactive web pages, and participatory social media. Yet, all this was still mediated by two-dimensional screens.

Today, we are witnessing the rise of Web 3.0, riding the convergence of high-bandwidth 5G connectivity, rapidly evolving AR eyewear, an emerging trillion-sensor economy, and powerful artificial intelligence.

As a result, we will soon be able to superimpose digital information atop any physical surrounding—freeing our eyes from the tyranny of the screen, immersing us in smart environments, and making our world endlessly dynamic.

In the third post of our five-part series on augmented reality, we will explore the convergence of AR, AI, sensors, and blockchain and dive into the implications through a key use case in manufacturing.

A Tale of Convergence
Let’s deconstruct everything beneath the sleek AR display.

It all begins with graphics processing units (GPUs)—electric circuits that perform rapid calculations to render images. (GPUs can be found in mobile phones, game consoles, and computers.)

However, because AR requires such extensive computing power, single GPUs will not suffice. Instead, blockchain can now enable distributed GPU processing power, and blockchains specifically dedicated to AR holographic processing are on the rise.

Next up, cameras and sensors will aggregate real-time data from any environment to seamlessly integrate physical and virtual worlds. Meanwhile, body-tracking sensors are critical for aligning a user’s self-rendering in AR with a virtually enhanced environment. Depth sensors then provide data for 3D spatial maps, while cameras absorb more surface-level, detailed visual input. In some cases, sensors might even collect biometric data, such as heart rate and brain activity, to incorporate health-related feedback in our everyday AR interfaces and personal recommendation engines.

The next step in the pipeline involves none other than AI. Processing enormous volumes of data instantaneously, embedded AI algorithms will power customized AR experiences in everything from artistic virtual overlays to personalized dietary annotations.

In retail, AIs will use your purchasing history, current closet inventory, and possibly even mood indicators to display digitally rendered items most suitable for your wardrobe, tailored to your measurements.

In healthcare, smart AR glasses will provide physicians with immediately accessible and maximally relevant information (parsed from the entirety of a patient’s medical records and current research) to aid in accurate diagnoses and treatments, freeing doctors to engage in the more human-centric tasks of establishing trust, educating patients and demonstrating empathy.

Image Credit: PHD Ventures.
Convergence in Manufacturing
One of the nearest-term use cases of AR is manufacturing, as large producers begin dedicating capital to enterprise AR headsets. And over the next ten years, AR will converge with AI, sensors, and blockchain to multiply manufacturer productivity and employee experience.

(1) Convergence with AI
In initial application, digital guides superimposed on production tables will vastly improve employee accuracy and speed, while minimizing error rates.

Already, the International Air Transport Association (IATA) — whose airlines supply 82 percent of air travel — recently implemented industrial tech company Atheer’s AR headsets in cargo management. And with barely any delay, IATA reported a whopping 30 percent improvement in cargo handling speed and no less than a 90 percent reduction in errors.

With similar success rates, Boeing brought Skylight’s smart AR glasses to the runway, now used in the manufacturing of hundreds of airplanes. Sure enough—the aerospace giant has now seen a 25 percent drop in production time and near-zero error rates.

Beyond cargo management and air travel, however, smart AR headsets will also enable on-the-job training without reducing the productivity of other workers or sacrificing hardware. Jaguar Land Rover, for instance, implemented Bosch’s Re’flekt One AR solution to gear technicians with “x-ray” vision: allowing them to visualize the insides of Range Rover Sport vehicles without removing any dashboards.

And as enterprise capabilities continue to soar, AIs will soon become the go-to experts, offering support to manufacturers in need of assembly assistance. Instant guidance and real-time feedback will dramatically reduce production downtime, boost overall output, and even help customers struggling with DIY assembly at home.

Perhaps one of the most profitable business opportunities, AR guidance through centralized AI systems will also serve to mitigate supply chain inefficiencies at extraordinary scale. Coordinating moving parts, eliminating the need for manned scanners at each checkpoint, and directing traffic within warehouses, joint AI-AR systems will vastly improve workflow while overseeing quality assurance.

After its initial implementation of AR “vision picking” in 2015, leading courier company DHL recently announced it would continue to use Google’s newest smart lens in warehouses across the world. Motivated by the initial group’s reported 15 percent jump in productivity, DHL’s decision is part of the logistics giant’s $300 million investment in new technologies.

And as direct-to-consumer e-commerce fundamentally transforms the retail sector, supply chain optimization will only grow increasingly vital. AR could very well prove the definitive step for gaining a competitive edge in delivery speeds.

As explained by Vital Enterprises CEO Ash Eldritch, “All these technologies that are coming together around artificial intelligence are going to augment the capabilities of the worker and that’s very powerful. I call it Augmented Intelligence. The idea is that you can take someone of a certain skill level and by augmenting them with artificial intelligence via augmented reality and the Internet of Things, you can elevate the skill level of that worker.”

Already, large producers like Goodyear, thyssenkrupp, and Johnson Controls are using the Microsoft HoloLens 2—priced at $3,500 per headset—for manufacturing and design purposes.

Perhaps the most heartening outcome of the AI-AR convergence is that, rather than replacing humans in manufacturing, AR is an ideal interface for human collaboration with AI. And as AI merges with human capital, prepare to see exponential improvements in productivity, professional training, and product quality.

(2) Convergence with Sensors
On the hardware front, these AI-AR systems will require a mass proliferation of sensors to detect the external environment and apply computer vision in AI decision-making.

To measure depth, for instance, some scanning depth sensors project a structured pattern of infrared light dots onto a scene, detecting and analyzing reflected light to generate 3D maps of the environment. Stereoscopic imaging, using two lenses, has also been commonly used for depth measurements. But leading technology like Microsoft’s HoloLens 2 and Intel’s RealSense 400-series camera implement a new method called “phased time-of-flight” (ToF).

In ToF sensing, the HoloLens 2 uses numerous lasers, each with 100 milliwatts (mW) of power, in quick bursts. The distance between nearby objects and the headset wearer is then measured by the amount of light in the return beam that has shifted from the original signal. Finally, the phase difference reveals the location of each object within the field of view, which enables accurate hand-tracking and surface reconstruction.

With a far lower computing power requirement, the phased ToF sensor is also more durable than stereoscopic sensing, which relies on the precise alignment of two prisms. The phased ToF sensor’s silicon base also makes it easily mass-produced, rendering the HoloLens 2 a far better candidate for widespread consumer adoption.

To apply inertial measurement—typically used in airplanes and spacecraft—the HoloLens 2 additionally uses a built-in accelerometer, gyroscope, and magnetometer. Further equipped with four “environment understanding cameras” that track head movements, the headset also uses a 2.4MP HD photographic video camera and ambient light sensor that work in concert to enable advanced computer vision.

For natural viewing experiences, sensor-supplied gaze tracking increasingly creates depth in digital displays. Nvidia’s work on Foveated AR Display, for instance, brings the primary foveal area into focus, while peripheral regions fall into a softer background— mimicking natural visual perception and concentrating computing power on the area that needs it most.

Gaze tracking sensors are also slated to grant users control over their (now immersive) screens without any hand gestures. Conducting simple visual cues, even staring at an object for more than three seconds, will activate commands instantaneously.

And our manufacturing example above is not the only one. Stacked convergence of blockchain, sensors, AI and AR will disrupt almost every major industry.

Take healthcare, for example, wherein biometric sensors will soon customize users’ AR experiences. Already, MIT Media Lab’s Deep Reality group has created an underwater VR relaxation experience that responds to real-time brain activity detected by a modified version of the Muse EEG. The experience even adapts to users’ biometric data, from heart rate to electro dermal activity (inputted from an Empatica E4 wristband).

Now rapidly dematerializing, sensors will converge with AR to improve physical-digital surface integration, intuitive hand and eye controls, and an increasingly personalized augmented world. Keep an eye on companies like MicroVision, now making tremendous leaps in sensor technology.

While I’ll be doing a deep dive into sensor applications across each industry in our next blog, it’s critical to first discuss how we might power sensor- and AI-driven augmented worlds.

(3) Convergence with Blockchain
Because AR requires much more compute power than typical 2D experiences, centralized GPUs and cloud computing systems are hard at work to provide the necessary infrastructure. Nonetheless, the workload is taxing and blockchain may prove the best solution.

A major player in this pursuit, Otoy aims to create the largest distributed GPU network in the world, called the Render Network RNDR. Built specifically on the Ethereum blockchain for holographic media, and undergoing Beta testing, this network is set to revolutionize AR deployment accessibility.

Alphabet Chairman Eric Schmidt (an investor in Otoy’s network), has even said, “I predicted that 90% of computing would eventually reside in the web based cloud… Otoy has created a remarkable technology which moves that last 10%—high-end graphics processing—entirely to the cloud. This is a disruptive and important achievement. In my view, it marks the tipping point where the web replaces the PC as the dominant computing platform of the future.”

Leveraging the crowd, RNDR allows anyone with a GPU to contribute their power to the network for a commission of up to $300 a month in RNDR tokens. These can then be redeemed in cash or used to create users’ own AR content.

In a double win, Otoy’s blockchain network and similar iterations not only allow designers to profit when not using their GPUs, but also democratize the experience for newer artists in the field.

And beyond these networks’ power suppliers, distributing GPU processing power will allow more manufacturing companies to access AR design tools and customize learning experiences. By further dispersing content creation across a broad network of individuals, blockchain also has the valuable potential to boost AR hardware investment across a number of industry beneficiaries.

On the consumer side, startups like Scanetchain are also entering the blockchain-AR space for a different reason. Allowing users to scan items with their smartphone, Scanetchain’s app provides access to a trove of information, from manufacturer and price, to origin and shipping details.

Based on NEM (a peer-to-peer cryptocurrency that implements a blockchain consensus algorithm), the app aims to make information far more accessible and, in the process, create a social network of purchasing behavior. Users earn tokens by watching ads, and all transactions are hashed into blocks and securely recorded.

The writing is on the wall—our future of brick-and-mortar retail will largely lean on blockchain to create the necessary digital links.

Final Thoughts
Integrating AI into AR creates an “auto-magical” manufacturing pipeline that will fundamentally transform the industry, cutting down on marginal costs, reducing inefficiencies and waste, and maximizing employee productivity.

Bolstering the AI-AR convergence, sensor technology is already blurring the boundaries between our augmented and physical worlds, soon to be near-undetectable. While intuitive hand and eye motions dictate commands in a hands-free interface, biometric data is poised to customize each AR experience to be far more in touch with our mental and physical health.

And underpinning it all, distributed computing power with blockchain networks like RNDR will democratize AR, boosting global consumer adoption at plummeting price points.

As AR soars in importance—whether in retail, manufacturing, entertainment, or beyond—the stacked convergence discussed above merits significant investment over the next decade. The augmented world is only just getting started.

Join Me
(1) A360 Executive Mastermind: Want even more context about how converging exponential technologies will transform your business and industry? Consider joining Abundance 360, a highly selective community of 360 exponentially minded CEOs, who are on a 25-year journey with me—or as I call it, a “countdown to the Singularity.” If you’d like to learn more and consider joining our 2020 membership, apply here.

Share this with your friends, especially if they are interested in any of the areas outlined above.

(2) Abundance-Digital Online Community: I’ve also created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is Singularity University’s ‘onramp’ for exponential entrepreneurs — those who want to get involved and play at a higher level. Click here to learn more.

This article originally appeared on Diamandis.com

Image Credit: Funky Focus / Pixabay Continue reading

Posted in Human Robots

#435614 3 Easy Ways to Evaluate AI Claims

When every other tech startup claims to use artificial intelligence, it can be tough to figure out if an AI service or product works as advertised. In the midst of the AI “gold rush,” how can you separate the nuggets from the fool’s gold?

There’s no shortage of cautionary tales involving overhyped AI claims. And applying AI technologies to health care, education, and law enforcement mean that getting it wrong can have real consequences for society—not just for investors who bet on the wrong unicorn.

So IEEE Spectrum asked experts to share their tips for how to identify AI hype in press releases, news articles, research papers, and IPO filings.

“It can be tricky, because I think the people who are out there selling the AI hype—selling this AI snake oil—are getting more sophisticated over time,” says Tim Hwang, director of the Harvard-MIT Ethics and Governance of AI Initiative.

The term “AI” is perhaps most frequently used to describe machine learning algorithms (and deep learning algorithms, which require even less human guidance) that analyze huge amounts of data and make predictions based on patterns that humans might miss. These popular forms of AI are mostly suited to specialized tasks, such as automatically recognizing certain objects within photos. For that reason, they are sometimes described as “weak” or “narrow” AI.

Some researchers and thought leaders like to talk about the idea of “artificial general intelligence” or “strong AI” that has human-level capacity and flexibility to handle many diverse intellectual tasks. But for now, this type of AI remains firmly in the realm of science fiction and is far from being realized in the real world.

“AI has no well-defined meaning and many so-called AI companies are simply trying to take advantage of the buzz around that term,” says Arvind Narayanan, a computer scientist at Princeton University. “Companies have even been caught claiming to use AI when, in fact, the task is done by human workers.”

Here are three ways to recognize AI hype.

Look for Buzzwords
One red flag is what Hwang calls the “hype salad.” This means stringing together the term “AI” with many other tech buzzwords such as “blockchain” or “Internet of Things.” That doesn’t automatically disqualify the technology, but spotting a high volume of buzzwords in a post, pitch, or presentation should raise questions about what exactly the company or individual has developed.

Other experts agree that strings of buzzwords can be a red flag. That’s especially true if the buzzwords are never really explained in technical detail, and are simply tossed around as vague, poorly-defined terms, says Marzyeh Ghassemi, a computer scientist and biomedical engineer at the University of Toronto in Canada.

“I think that if it looks like a Google search—picture ‘interpretable blockchain AI deep learning medicine’—it's probably not high-quality work,” Ghassemi says.

Hwang also suggests mentally replacing all mentions of “AI” in an article with the term “magical fairy dust.” It’s a way of seeing whether an individual or organization is treating the technology like magic. If so—that’s another good reason to ask more questions about what exactly the AI technology involves.

And even the visual imagery used to illustrate AI claims can indicate that an individual or organization is overselling the technology.

“I think that a lot of the people who work on machine learning on a day-to-day basis are pretty humble about the technology, because they’re largely confronted with how frequently it just breaks and doesn't work,” Hwang says. “And so I think that if you see a company or someone representing AI as a Terminator head, or a big glowing HAL eye or something like that, I think it’s also worth asking some questions.”

Interrogate the Data

It can be hard to evaluate AI claims without any relevant expertise, says Ghassemi at the University of Toronto. Even experts need to know the technical details of the AI algorithm in question and have some access to the training data that shaped the AI model’s predictions. Still, savvy readers with some basic knowledge of applied statistics can search for red flags.

To start, readers can look for possible bias in training data based on small sample sizes or a skewed population that fails to reflect the broader population, Ghassemi says. After all, an AI model trained only on health data from white men would not necessarily achieve similar results for other populations of patients.

“For me, a red flag is not demonstrating deep knowledge of how your labels are defined.”
—Marzyeh Ghassemi, University of Toronto

How machine learning and deep learning models perform also depends on how well humans labeled the sample datasets use to train these programs. This task can be straightforward when labeling photos of cats versus dogs, but gets more complicated when assigning disease diagnoses to certain patient cases.

Medical experts frequently disagree with each other on diagnoses—which is why many patients seek a second opinion. Not surprisingly, this ambiguity can also affect the diagnostic labels that experts assign in training datasets. “For me, a red flag is not demonstrating deep knowledge of how your labels are defined,” Ghassemi says.

Such training data can also reflect the cultural stereotypes and biases of the humans who labeled the data, says Narayanan at Princeton University. Like Ghassemi, he recommends taking a hard look at exactly what the AI has learned: “A good way to start critically evaluating AI claims is by asking questions about the training data.”

Another red flag is presenting an AI system’s performance through a single accuracy figure without much explanation, Narayanan says. Claiming that an AI model achieves “99 percent” accuracy doesn’t mean much without knowing the baseline for comparison—such as whether other systems have already achieved 99 percent accuracy—or how well that accuracy holds up in situations beyond the training dataset.

Narayanan also emphasized the need to ask questions about an AI model’s false positive rate—the rate of making wrong predictions about the presence of a given condition. Even if the false positive rate of a hypothetical AI service is just one percent, that could have major consequences if that service ends up screening millions of people for cancer.

Readers can also consider whether using AI in a given situation offers any meaningful improvement compared to traditional statistical methods, says Clayton Aldern, a data scientist and journalist who serves as managing director for Caldern LLC. He gave the hypothetical example of a “super-duper-fancy deep learning model” that achieves a prediction accuracy of 89 percent, compared to a “little polynomial regression model” that achieves 86 percent on the same dataset.

“We're talking about a three-percentage-point increase on something that you learned about in Algebra 1,” Aldern says. “So is it worth the hype?”

Don’t Ignore the Drawbacks

The hype surrounding AI isn’t just about the technical merits of services and products driven by machine learning. Overblown claims about the beneficial impacts of AI technology—or vague promises to address ethical issues related to deploying it—should also raise red flags.

“If a company promises to use its tech ethically, it is important to question if its business model aligns with that promise,” Narayanan says. “Even if employees have noble intentions, it is unrealistic to expect the company as a whole to resist financial imperatives.”

One example might be a company with a business model that depends on leveraging customers’ personal data. Such companies “tend to make empty promises when it comes to privacy,” Narayanan says. And, if companies hire workers to produce training data, it’s also worth asking whether the companies treat those workers ethically.

The transparency—or lack thereof—about any AI claim can also be telling. A company or research group can minimize concerns by publishing technical claims in peer-reviewed journals or allowing credible third parties to evaluate their AI without giving away big intellectual property secrets, Narayanan says. Excessive secrecy is a big red flag.

With these strategies, you don’t need to be a computer engineer or data scientist to start thinking critically about AI claims. And, Narayanan says, the world needs many people from different backgrounds for societies to fully consider the real-world implications of AI.

Editor’s Note: The original version of this story misspelled Clayton Aldern’s last name as Alderton. Continue reading

Posted in Human Robots

#435423 Moving Beyond Mind-Controlled Limbs to ...

Brain-machine interface enthusiasts often gush about “closing the loop.” It’s for good reason. On the implant level, it means engineering smarter probes that only activate when they detect faulty electrical signals in brain circuits. Elon Musk’s Neuralink—among other players—are readily pursuing these bi-directional implants that both measure and zap the brain.

But to scientists laboring to restore functionality to paralyzed patients or amputees, “closing the loop” has broader connotations. Building smart mind-controlled robotic limbs isn’t enough; the next frontier is restoring sensation in offline body parts. To truly meld biology with machine, the robotic appendage has to “feel one” with the body.

This month, two studies from Science Robotics describe complementary ways forward. In one, scientists from the University of Utah paired a state-of-the-art robotic arm—the DEKA LUKE—with electrically stimulating remaining nerves above the attachment point. Using artificial zaps to mimic the skin’s natural response patterns to touch, the team dramatically increased the patient’s ability to identify objects. Without much training, he could easily discriminate between the small and large and the soft and hard while blindfolded and wearing headphones.

In another, a team based at the National University of Singapore took inspiration from our largest organ, the skin. Mimicking the neural architecture of biological skin, the engineered “electronic skin” not only senses temperature, pressure, and humidity, but continues to function even when scraped or otherwise damaged. Thanks to artificial nerves that transmit signals far faster than our biological ones, the flexible e-skin shoots electrical data 1,000 times quicker than human nerves.

Together, the studies marry neuroscience and robotics. Representing the latest push towards closing the loop, they show that integrating biological sensibilities with robotic efficiency isn’t impossible (super-human touch, anyone?). But more immediately—and more importantly—they’re beacons of hope for patients who hope to regain their sense of touch.

For one of the participants, a late middle-aged man with speckled white hair who lost his forearm 13 years ago, superpowers, cyborgs, or razzle-dazzle brain implants are the last thing on his mind. After a barrage of emotionally-neutral scientific tests, he grasped his wife’s hand and felt her warmth for the first time in over a decade. His face lit up in a blinding smile.

That’s what scientists are working towards.

Biomimetic Feedback
The human skin is a marvelous thing. Not only does it rapidly detect a multitude of sensations—pressure, temperature, itch, pain, humidity—its wiring “binds” disparate signals together into a sensory fingerprint that helps the brain identify what it’s feeling at any moment. Thanks to over 45 miles of nerves that connect the skin, muscles, and brain, you can pick up a half-full coffee cup, knowing that it’s hot and sloshing, while staring at your computer screen. Unfortunately, this complexity is also why restoring sensation is so hard.

The sensory electrode array implanted in the participant’s arm. Image Credit: George et al., Sci. Robot. 4, eaax2352 (2019)..
However, complex neural patterns can also be a source of inspiration. Previous cyborg arms are often paired with so-called “standard” sensory algorithms to induce a basic sense of touch in the missing limb. Here, electrodes zap residual nerves with intensities proportional to the contact force: the harder the grip, the stronger the electrical feedback. Although seemingly logical, that’s not how our skin works. Every time the skin touches or leaves an object, its nerves shoot strong bursts of activity to the brain; while in full contact, the signal is much lower. The resulting electrical strength curve resembles a “U.”

The LUKE hand. Image Credit: George et al., Sci. Robot. 4, eaax2352 (2019).
The team decided to directly compare standard algorithms with one that better mimics the skin’s natural response. They fitted a volunteer with a robotic LUKE arm and implanted an array of electrodes into his forearm—right above the amputation—to stimulate the remaining nerves. When the team activated different combinations of electrodes, the man reported sensations of vibration, pressure, tapping, or a sort of “tightening” in his missing hand. Some combinations of zaps also made him feel as if he were moving the robotic arm’s joints.

In all, the team was able to carefully map nearly 120 sensations to different locations on the phantom hand, which they then overlapped with contact sensors embedded in the LUKE arm. For example, when the patient touched something with his robotic index finger, the relevant electrodes sent signals that made him feel as if he were brushing something with his own missing index fingertip.

Standard sensory feedback already helped: even with simple electrical stimulation, the man could tell apart size (golf versus lacrosse ball) and texture (foam versus plastic) while blindfolded and wearing noise-canceling headphones. But when the team implemented two types of neuromimetic feedback—electrical zaps that resembled the skin’s natural response—his performance dramatically improved. He was able to identify objects much faster and more accurately under their guidance. Outside the lab, he also found it easier to cook, feed, and dress himself. He could even text on his phone and complete routine chores that were previously too difficult, such as stuffing an insert into a pillowcase, hammering a nail, or eating hard-to-grab foods like eggs and grapes.

The study shows that the brain more readily accepts biologically-inspired electrical patterns, making it a relatively easy—but enormously powerful—upgrade that seamlessly integrates the robotic arms with the host. “The functional and emotional benefits…are likely to be further enhanced with long-term use, and efforts are underway to develop a portable take-home system,” the team said.

E-Skin Revolution: Asynchronous Coded Electronic Skin (ACES)
Flexible electronic skins also aren’t new, but the second team presented an upgrade in both speed and durability while retaining multiplexed sensory capabilities.

Starting from a combination of rubber, plastic, and silicon, the team embedded over 200 sensors onto the e-skin, each capable of discerning contact, pressure, temperature, and humidity. They then looked to the skin’s nervous system for inspiration. Our skin is embedded with a dense array of nerve endings that individually transmit different types of sensations, which are integrated inside hubs called ganglia. Compared to having every single nerve ending directly ping data to the brain, this “gather, process, and transmit” architecture rapidly speeds things up.

The team tapped into this biological architecture. Rather than pairing each sensor with a dedicated receiver, ACES sends all sensory data to a single receiver—an artificial ganglion. This setup lets the e-skin’s wiring work as a whole system, as opposed to individual electrodes. Every sensor transmits its data using a characteristic pulse, which allows it to be uniquely identified by the receiver.

The gains were immediate. First was speed. Normally, sensory data from multiple individual electrodes need to be periodically combined into a map of pressure points. Here, data from thousands of distributed sensors can independently go to a single receiver for further processing, massively increasing efficiency—the new e-skin’s transmission rate is roughly 1,000 times faster than that of human skin.

Second was redundancy. Because data from individual sensors are aggregated, the system still functioned even when any individual receptors are damaged, making it far more resilient than previous attempts. Finally, the setup could easily scale up. Although the team only tested the idea with 240 sensors, theoretically the system should work with up to 10,000.

The team is now exploring ways to combine their invention with other material layers to make it water-resistant and self-repairable. As you might’ve guessed, an immediate application is to give robots something similar to complex touch. A sensory upgrade not only lets robots more easily manipulate tools, doorknobs, and other objects in hectic real-world environments, it could also make it easier for machines to work collaboratively with humans in the future (hey Wall-E, care to pass the salt?).

Dexterous robots aside, the team also envisions engineering better prosthetics. When coated onto cyborg limbs, for example, ACES may give them a better sense of touch that begins to rival the human skin—or perhaps even exceed it.

Regardless, efforts that adapt the functionality of the human nervous system to machines are finally paying off, and more are sure to come. Neuromimetic ideas may very well be the link that finally closes the loop.

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#435308 Brain-Machine Interfaces Are Getting ...

Elon Musk grabbed a lot of attention with his July 16 announcement that his company Neuralink plans to implant electrodes into the brains of people with paralysis by next year. Their first goal is to create assistive technology to help people who can’t move or are unable to communicate.

If you haven’t been paying attention, brain-machine interfaces (BMIs) that allow people to control robotic arms with their thoughts might sound like science fiction. But science and engineering efforts have already turned it into reality.

In a few research labs around the world, scientists and physicians have been implanting devices into the brains of people who have lost the ability to control their arms or hands for over a decade. In our own research group at the University of Pittsburgh, we’ve enabled people with paralyzed arms and hands to control robotic arms that allow them to grasp and move objects with relative ease. They can even experience touch-like sensations from their own hand when the robot grasps objects.

At its core, a BMI is pretty straightforward. In your brain, microscopic cells called neurons are sending signals back and forth to each other all the time. Everything you think, do and feel as you interact with the world around you is the result of the activity of these 80 billion or so neurons.

If you implant a tiny wire very close to one of these neurons, you can record the electrical activity it generates and send it to a computer. Record enough of these signals from the right area of the brain and it becomes possible to control computers, robots, or anything else you might want, simply by thinking about moving. But doing this comes with tremendous technical challenges, especially if you want to record from hundreds or thousands of neurons.

What Neuralink Is Bringing to the Table
Elon Musk founded Neuralink in 2017, aiming to address these challenges and raise the bar for implanted neural interfaces.

Perhaps the most impressive aspect of Neuralink’s system is the breadth and depth of their approach. Building a BMI is inherently interdisciplinary, requiring expertise in electrode design and microfabrication, implantable materials, surgical methods, electronics, packaging, neuroscience, algorithms, medicine, regulatory issues, and more. Neuralink has created a team that spans most, if not all, of these areas.

With all of this expertise, Neuralink is undoubtedly moving the field forward, and improving their technology rapidly. Individually, many of the components of their system represent significant progress along predictable paths. For example, their electrodes, that they call threads, are very small and flexible; many researchers have tried to harness those properties to minimize the chance the brain’s immune response would reject the electrodes after insertion. Neuralink has also developed high-performance miniature electronics, another focus area for labs working on BMIs.

Often overlooked in academic settings, however, is how an entire system would be efficiently implanted in a brain.

Neuralink’s BMI requires brain surgery. This is because implanted electrodes that are in intimate contact with neurons will always outperform non-invasive electrodes where neurons are far away from the electrodes sitting outside the skull. So, a critical question becomes how to minimize the surgical challenges around getting the device into a brain.

Maybe the most impressive aspect of Neuralink’s announcement was that they created a 3,000-electrode neural interface where electrodes could be implanted at a rate of between 30 and 200 per minute. Each thread of electrodes is implanted by a sophisticated surgical robot that essentially acts like a sewing machine. This all happens while specifically avoiding blood vessels that blanket the surface of the brain. The robotics and imaging that enable this feat, with tight integration to the entire device, is striking.

Neuralink has thought through the challenge of developing a clinically viable BMI from beginning to end in a way that few groups have done, though they acknowledge that many challenges remain as they work towards getting this technology into human patients in the clinic.

Figuring Out What More Electrodes Gets You
The quest for implantable devices with thousands of electrodes is not only the domain of private companies. DARPA, the NIH BRAIN Initiative, and international consortiums are working on neurotechnologies for recording and stimulating in the brain with goals of tens of thousands of electrodes. But what might scientists do with the information from 1,000, 3,000, or maybe even 100,000 neurons?

At some level, devices with more electrodes might not actually be necessary to have a meaningful impact in people’s lives. Effective control of computers for access and communication, of robotic limbs to grasp and move objects as well as of paralyzed muscles is already happening—in people. And it has been for a number of years.

Since the 1990s, the Utah Array, which has just 100 electrodes and is manufactured by Blackrock Microsystems, has been a critical device in neuroscience and clinical research. This electrode array is FDA-cleared for temporary neural recording. Several research groups, including our own, have implanted Utah Arrays in people that lasted multiple years.

Currently, the biggest constraints are related to connectors, electronics, and system-level engineering, not the implanted electrode itself—although increasing the electrodes’ lifespan to more than five years would represent a significant advance. As those technical capabilities improve, it might turn out that the ability to accurately control computers and robots is limited more by scientists’ understanding of what the neurons are saying—that is, the neural code—than by the number of electrodes on the device.

Even the most capable implanted system, and maybe the most capable devices researchers can reasonably imagine, might fall short of the goal of actually augmenting skilled human performance. Nevertheless, Neuralink’s goal of creating better BMIs has the potential to improve the lives of people who can’t move or are unable to communicate. Right now, Musk’s vision of using BMIs to meld physical brains and intelligence with artificial ones is no more than a dream.

So, what does the future look like for Neuralink and other groups creating implantable BMIs? Devices with more electrodes that last longer and are connected to smaller and more powerful wireless electronics are essential. Better devices themselves, however, are insufficient. Continued public and private investment in companies and academic research labs, as well as innovative ways for these groups to work together to share technologies and data, will be necessary to truly advance scientists’ understanding of the brain and deliver on the promise of BMIs to improve peoples’ lives.

While researchers need to keep the future societal implications of advanced neurotechnologies in mind—there’s an essential role for ethicists and regulation—BMIs could be truly transformative as they help more people overcome limitations caused by injury or disease in the brain and body.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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