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#432271 Your Shopping Experience Is on the Verge ...

Exponential technologies (AI, VR, 3D printing, and networks) are radically reshaping traditional retail.

E-commerce giants (Amazon, Walmart, Alibaba) are digitizing the retail industry, riding the exponential growth of computation.

Many brick-and-mortar stores have already gone bankrupt, or migrated their operations online.

Massive change is occurring in this arena.

For those “real-life stores” that survive, an evolution is taking place from a product-centric mentality to an experience-based business model by leveraging AI, VR/AR, and 3D printing.

Let’s dive in.

E-Commerce Trends
Last year, 3.8 billion people were connected online. By 2024, thanks to 5G, stratospheric and space-based satellites, we will grow to 8 billion people online, each with megabit to gigabit connection speeds.

These 4.2 billion new digital consumers will begin buying things online, a potential bonanza for the e-commerce world.

At the same time, entrepreneurs seeking to service these four-billion-plus new consumers can now skip the costly steps of procuring retail space and hiring sales clerks.

Today, thanks to global connectivity, contract production, and turnkey pack-and-ship logistics, an entrepreneur can go from an idea to building and scaling a multimillion-dollar business from anywhere in the world in record time.

And while e-commerce sales have been exploding (growing from $34 billion in Q1 2009 to $115 billion in Q3 2017), e-commerce only accounted for about 10 percent of total retail sales in 2017.

In 2016, global online sales totaled $1.8 trillion. Remarkably, this $1.8 trillion was spent by only 1.5 billion people — a mere 20 percent of Earth’s global population that year.

There’s plenty more room for digital disruption.

AI and the Retail Experience
For the business owner, AI will demonetize e-commerce operations with automated customer service, ultra-accurate supply chain modeling, marketing content generation, and advertising.

In the case of customer service, imagine an AI that is trained by every customer interaction, learns how to answer any consumer question perfectly, and offers feedback to product designers and company owners as a result.

Facebook’s handover protocol allows live customer service representatives and language-learning bots to work within the same Facebook Messenger conversation.

Taking it one step further, imagine an AI that is empathic to a consumer’s frustration, that can take any amount of abuse and come back with a smile every time. As one example, meet Ava. “Ava is a virtual customer service agent, to bring a whole new level of personalization and brand experience to that customer experience on a day-to-day basis,” says Greg Cross, CEO of Ava’s creator, an Austrian company called Soul Machines.

Predictive modeling and machine learning are also optimizing product ordering and the supply chain process. For example, Skubana, a platform for online sellers, leverages data analytics to provide entrepreneurs constant product performance feedback and maintain optimal warehouse stock levels.

Blockchain is set to follow suit in the retail space. ShipChain and Ambrosus plan to introduce transparency and trust into shipping and production, further reducing costs for entrepreneurs and consumers.

Meanwhile, for consumers, personal shopping assistants are shifting the psychology of the standard shopping experience.

Amazon’s Alexa marks an important user interface moment in this regard.

Alexa is in her infancy with voice search and vocal controls for smart homes. Already, Amazon’s Alexa users, on average, spent more on Amazon.com when purchasing than standard Amazon Prime customers — $1,700 versus $1,400.

As I’ve discussed in previous posts, the future combination of virtual reality shopping, coupled with a personalized, AI-enabled fashion advisor will make finding, selecting, and ordering products fast and painless for consumers.

But let’s take it one step further.

Imagine a future in which your personal AI shopper knows your desires better than you do. Possible? I think so. After all, our future AIs will follow us, watch us, and observe our interactions — including how long we glance at objects, our facial expressions, and much more.

In this future, shopping might be as easy as saying, “Buy me a new outfit for Saturday night’s dinner party,” followed by a surprise-and-delight moment in which the outfit that arrives is perfect.

In this future world of AI-enabled shopping, one of the most disruptive implications is that advertising is now dead.

In a world where an AI is buying my stuff, and I’m no longer in the decision loop, why would a big brand ever waste money on a Super Bowl advertisement?

The dematerialization, demonetization, and democratization of personalized shopping has only just begun.

The In-Store Experience: Experiential Retailing
In 2017, over 6,700 brick-and-mortar retail stores closed their doors, surpassing the former record year for store closures set in 2008 during the financial crisis. Regardless, business is still booming.

As shoppers seek the convenience of online shopping, brick-and-mortar stores are tapping into the power of the experience economy.

Rather than focusing on the practicality of the products they buy, consumers are instead seeking out the experience of going shopping.

The Internet of Things, artificial intelligence, and computation are exponentially improving the in-person consumer experience.

As AI dominates curated online shopping, AI and data analytics tools are also empowering real-life store owners to optimize staffing, marketing strategies, customer relationship management, and inventory logistics.

In the short term,retail store locations will serve as the next big user interface for production 3D printing (custom 3D printed clothes at the Ministry of Supply), virtual and augmented reality (DIY skills clinics), and the Internet of Things (checkout-less shopping).

In the long term,we’ll see how our desire for enhanced productivity and seamless consumption balances with our preference for enjoyable real-life consumer experiences — all of which will be driven by exponential technologies.

One thing is certain: the nominal shopping experience is on the verge of a major transformation.

Implications
The convergence of exponential technologies has already revamped how and where we shop, how we use our time, and how much we pay.

Twenty years ago, Amazon showed us how the web could offer each of us the long tail of available reading material, and since then, the world of e-commerce has exploded.

And yet we still haven’t experienced the cost savings coming our way from drone delivery, the Internet of Things, tokenized ecosystems, the impact of truly powerful AI, or even the other major applications for 3D printing and AR/VR.

Perhaps nothing will be more transformed than today’s $20 trillion retail sector.

Hold on, stay tuned, and get your AI-enabled cryptocurrency ready.

Join Me
Abundance Digital Online Community: I’ve created a digital/online community of bold, abundance-minded entrepreneurs called Abundance Digital.

Abundance Digital is my ‘onramp’ for exponential entrepreneurs — those who want to get involved and play at a higher level. Click here to learn more.

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#432036 The Power to Upgrade Our Own Biology Is ...

Upgrading our biology may sound like science fiction, but attempts to improve humanity actually date back thousands of years. Every day, we enhance ourselves through seemingly mundane activities such as exercising, meditating, or consuming performance-enhancing drugs, such as caffeine or adderall. However, the tools with which we upgrade our biology are improving at an accelerating rate and becoming increasingly invasive.

In recent decades, we have developed a wide array of powerful methods, such as genetic engineering and brain-machine interfaces, that are redefining our humanity. In the short run, such enhancement technologies have medical applications and may be used to treat many diseases and disabilities. Additionally, in the coming decades, they could allow us to boost our physical abilities or even digitize human consciousness.

What’s New?
Many futurists argue that our devices, such as our smartphones, are already an extension of our cortex and in many ways an abstract form of enhancement. According to philosophers Andy Clark and David Chalmers’ theory of extended mind, we use technology to expand the boundaries of the human mind beyond our skulls.

One can argue that having access to a smartphone enhances one’s cognitive capacities and abilities and is an indirect form of enhancement of its own. It can be considered an abstract form of brain-machine interface. Beyond that, wearable devices and computers are already accessible in the market, and people like athletes use them to boost their progress.

However, these interfaces are becoming less abstract.

Not long ago, Elon Musk announced a new company, Neuralink, with the goal of merging the human mind with AI. The past few years have seen remarkable developments in both the hardware and software of brain-machine interfaces. Experts are designing more intricate electrodes while programming better algorithms to interpret neural signals. Scientists have already succeeded in enabling paralyzed patients to type with their minds, and are even allowing brains to communicate with one another purely through brainwaves.

Ethical Challenges of Enhancement
There are many social and ethical implications of such advancements.

One of the most fundamental issues with cognitive and physical enhancement techniques is that they contradict the very definition of merit and success that society has relied on for millennia. Many forms of performance-enhancing drugs have been considered “cheating” for the longest time.

But perhaps we ought to revisit some of our fundamental assumptions as a society.

For example, we like to credit hard work and talent in a fair manner, where “fair” generally implies that an individual has acted in a way that has served him to merit his rewards. If you are talented and successful, it is considered to be because you chose to work hard and take advantage of the opportunities available to you. But by these standards, how much of our accomplishments can we truly be credited for?

For instance, the genetic lottery can have an enormous impact on an individual’s predisposition and personality, which can in turn affect factors such as motivation, reasoning skills, and other mental abilities. Many people are born with a natural ability or a physique that gives them an advantage in a particular area or predisposes them to learn faster. But is it justified to reward someone for excellence if their genes had a pivotal role in their path to success?

Beyond that, there are already many ways in which we take “shortcuts” to better mental performance. Seemingly mundane activities like drinking coffee, meditating, exercising, or sleeping well can boost one’s performance in any given area and are tolerated by society. Even the use of language can have positive physical and psychological effects on the human brain, which can be liberating to the individual and immensely beneficial to society at large. And let’s not forget the fact that some of us are born into more access to developing literacy than others.

Given all these reasons, one could argue that cognitive abilities and talents are currently derived more from uncontrollable factors and luck than we like to admit. If anything, technologies like brain-machine interfaces can enhance individual autonomy and allow one a choice of how capable they become.

As Karim Jebari points out (pdf), if a certain characteristic or trait is required to perform a particular role and an individual lacks this trait, would it be wrong to implement the trait through brain-machine interfaces or genetic engineering? How is this different from any conventional form of learning or acquiring a skill? If anything, this would be removing limitations on individuals that result from factors outside their control, such as biological predisposition (or even traits induced from traumatic experiences) to act or perform in a certain way.

Another major ethical concern is equality. As with any other emerging technology, there are valid concerns that cognitive enhancement tech will benefit only the wealthy, thus exacerbating current inequalities. This is where public policy and regulations can play a pivotal role in the impact of technology on society.

Enhancement technologies can either contribute to inequality or allow us to solve it. Educating and empowering the under-privileged can happen at a much more rapid rate, helping the overall rate of human progress accelerate. The “normal range” for human capacity and intelligence, however it is defined, could shift dramatically towards more positive trends.

Many have also raised concerns over the negative applications of government-led biological enhancement, including eugenics-like movements and super-soldiers. Naturally, there are also issues of safety, security, and well-being, especially within the early stages of experimentation with enhancement techniques.

Brain-machine interfaces, for instance, could have implications on autonomy. The interface involves using information extracted from the brain to stimulate or modify systems in order to accomplish a goal. This part of the process can be enhanced by implementing an artificial intelligence system onto the interface—one that exposes the possibility of a third party potentially manipulating individual’s personalities, emotions, and desires by manipulating the interface.

A Tool For Transcendence
It’s important to discuss these risks, not so that we begin to fear and avoid such technologies, but so that we continue to advance in a way that minimizes harm and allows us to optimize the benefits.

Stephen Hawking notes that “with genetic engineering, we will be able to increase the complexity of our DNA, and improve the human race.” Indeed, the potential advantages of modifying biology are revolutionary. Doctors would gain access to a powerful tool to tackle disease, allowing us to live longer and healthier lives. We might be able to extend our lifespan and tackle aging, perhaps a critical step to becoming a space-faring species. We may begin to modify the brain’s building blocks to become more intelligent and capable of solving grand challenges.

In their book Evolving Ourselves, Juan Enriquez and Steve Gullans describe a world where evolution is no longer driven by natural processes. Instead, it is driven by human choices, through what they call unnatural selection and non-random mutation. Human enhancement is bringing us closer to such a world—it could allow us to take control of our evolution and truly shape the future of our species.

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#431873 Why the World Is Still Getting ...

If you read or watch the news, you’ll likely think the world is falling to pieces. Trends like terrorism, climate change, and a growing population straining the planet’s finite resources can easily lead you to think our world is in crisis.
But there’s another story, a story the news doesn’t often report. This story is backed by data, and it says we’re actually living in the most peaceful, abundant time in history, and things are likely to continue getting better.
The News vs. the Data
The reality that’s often clouded by a constant stream of bad news is we’re actually seeing a massive drop in poverty, fewer deaths from violent crime and preventable diseases. On top of that, we’re the most educated populace to ever walk the planet.
“Violence has been in decline for thousands of years, and today we may be living in the most peaceful era in the existence of our species.” –Steven Pinker
In the last hundred years, we’ve seen the average human life expectancy nearly double, the global GDP per capita rise exponentially, and childhood mortality drop 10-fold.

That’s pretty good progress! Maybe the world isn’t all gloom and doom.If you’re still not convinced the world is getting better, check out the charts in this article from Vox and on Peter Diamandis’ website for a lot more data.
Abundance for All Is Possible
So now that you know the world isn’t so bad after all, here’s another thing to think about: it can get much better, very soon.
In their book Abundance: The Future Is Better Than You Think, Steven Kotler and Peter Diamandis suggest it may be possible for us to meet and even exceed the basic needs of all the people living on the planet today.
“In the hands of smart and driven innovators, science and technology take things which were once scarce and make them abundant and accessible to all.”
This means making sure every single person in the world has adequate food, water and shelter, as well as a good education, access to healthcare, and personal freedom.
This might seem unimaginable, especially if you tend to think the world is only getting worse. But given how much progress we’ve already made in the last few hundred years, coupled with the recent explosion of information sharing and new, powerful technologies, abundance for all is not as out of reach as you might believe.
Throughout history, we’ve seen that in the hands of smart and driven innovators, science and technology take things which were once scarce and make them abundant and accessible to all.
Napoleon III
In Abundance, Diamandis and Kotler tell the story of how aluminum went from being one of the rarest metals on the planet to being one of the most abundant…
In the 1800s, aluminum was more valuable than silver and gold because it was rarer. So when Napoleon III entertained the King of Siam, the king and his guests were honored by being given aluminum utensils, while the rest of the dinner party ate with gold.
But aluminum is not really rare.
In fact, aluminum is the third most abundant element in the Earth’s crust, making up 8.3% of the weight of our planet. But it wasn’t until chemists Charles Martin Hall and Paul Héroult discovered how to use electrolysis to cheaply separate aluminum from surrounding materials that the element became suddenly abundant.
The problems keeping us from achieving a world where everyone’s basic needs are met may seem like resource problems — when in reality, many are accessibility problems.
The Engine Driving Us Toward Abundance: Exponential Technology
History is full of examples like the aluminum story. The most powerful one of the last few decades is information technology. Think about all the things that computers and the internet made abundant that were previously far less accessible because of cost or availability … Here are just a few examples:

Easy access to the world’s information
Ability to share information freely with anyone and everyone
Free/cheap long-distance communication
Buying and selling goods/services regardless of location

Less than two decades ago, when someone reached a certain level of economic stability, they could spend somewhere around $10K on stereos, cameras, entertainment systems, etc — today, we have all that equipment in the palm of our hand.
Now, there is a new generation of technologies heavily dependant on information technology and, therefore, similarly riding the wave of exponential growth. When put to the right use, emerging technologies like artificial intelligence, robotics, digital manufacturing, nano-materials and digital biology make it possible for us to drastically raise the standard of living for every person on the planet.

These are just some of the innovations which are unlocking currently scarce resources:

IBM’s Watson Health is being trained and used in medical facilities like the Cleveland Clinic to help doctors diagnose disease. In the future, it’s likely we’ll trust AI just as much, if not more than humans to diagnose disease, allowing people all over the world to have access to great diagnostic tools regardless of whether there is a well-trained doctor near them.

Solar power is now cheaper than fossil fuels in some parts of the world, and with advances in new materials and storage, the cost may decrease further. This could eventually lead to nearly-free, clean energy for people across the world.

Google’s GMNT network can now translate languages as well as a human, unlocking the ability for people to communicate globally as we never have before.

Self-driving cars are already on the roads of several American cities and will be coming to a road near you in the next couple years. Considering the average American spends nearly two hours driving every day, not having to drive would free up an increasingly scarce resource: time.

The Change-Makers
Today’s innovators can create enormous change because they have these incredible tools—which would have once been available only to big organizations—at their fingertips. And, as a result of our hyper-connected world, there is an unprecedented ability for people across the planet to work together to create solutions to some of our most pressing problems today.
“In today’s hyperlinked world, solving problems anywhere, solves problems everywhere.” –Peter Diamandis and Steven Kotler, Abundance
According to Diamandis and Kotler, there are three groups of people accelerating positive change.

DIY InnovatorsIn the 1970s and 1980s, the Homebrew Computer Club was a meeting place of “do-it-yourself” computer enthusiasts who shared ideas and spare parts. By the 1990s and 2000s, that little club became known as an inception point for the personal computer industry — dozens of companies, including Apple Computer, can directly trace their origins back to Homebrew. Since then, we’ve seen the rise of the social entrepreneur, the Maker Movement and the DIY Bio movement, which have similar ambitions to democratize social reform, manufacturing, and biology, the way Homebrew democratized computers. These are the people who look for new opportunities and aren’t afraid to take risks to create something new that will change the status-quo.
Techno-PhilanthropistsUnlike the robber barons of the 19th and early 20th centuries, today’s “techno-philanthropists” are not just giving away some of their wealth for a new museum, they are using their wealth to solve global problems and investing in social entrepreneurs aiming to do the same. The Bill and Melinda Gates Foundation has given away at least $28 billion, with a strong focus on ending diseases like polio, malaria, and measles for good. Jeff Skoll, after cashing out of eBay with $2 billion in 1998, went on to create the Skoll Foundation, which funds social entrepreneurs across the world. And last year, Mark Zuckerberg and Priscilla Chan pledged to give away 99% of their $46 billion in Facebook stock during their lifetimes.
The Rising BillionCisco estimates that by 2020, there will be 4.1 billion people connected to the internet, up from 3 billion in 2015. This number might even be higher, given the efforts of companies like Facebook, Google, Virgin Group, and SpaceX to bring internet access to the world. That’s a billion new people in the next several years who will be connected to the global conversation, looking to learn, create and better their own lives and communities.In his book, Fortune at the Bottom of the Pyramid, C.K. Pahalad writes that finding co-creative ways to serve this rising market can help lift people out of poverty while creating viable businesses for inventive companies.

The Path to Abundance
Eager to create change, innovators armed with powerful technologies can accomplish incredible feats. Kotler and Diamandis imagine that the path to abundance occurs in three tiers:

Basic Needs (food, water, shelter)
Tools of Growth (energy, education, access to information)
Ideal Health and Freedom

Of course, progress doesn’t always happen in a straight, logical way, but having a framework to visualize the needs is helpful.
Many people don’t believe it’s possible to end the persistent global problems we’re facing. However, looking at history, we can see many examples where technological tools have unlocked resources that previously seemed scarce.
Technological solutions are not always the answer, and we need social change and policy solutions as much as we need technology solutions. But we have seen time and time again, that powerful tools in the hands of innovative, driven change-makers can make the seemingly impossible happen.

You can download the full “Path to Abundance” infographic here. It was created under a CC BY-NC-ND license. If you share, please attribute to Singularity University.
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#431817 This Week’s Awesome Stories From ...

BITCOIN
Bitcoin Is a Delusion That Could Conquer the WorldDerek Thompson | The Atlantic“What seems most certain is that the future of money will test our conventional definitions—of currencies, of bubbles, and of initial offerings. What’s happening this month with bitcoin feels like an unsustainable paroxysm. But it’s foolish to try to develop rational models for when such a market will correct itself. Prices, like currencies, are collective illusions.”
SPACE
This Engineer Is Building a DIY Mars Habitat in His BackyardDaniel Oberhaus | Motherboard“For over a year, Raymond and his wife have been running a fully operational, self-sustaining ‘Mars habitat’ in their backyard. They’ve personally sunk around $200,000 into the project and anticipate spending several thousand more before they’re finished. The habitat is the subject of a popularYouTube channel maintained by Raymond, where he essentiallyLARPs the 2015 Matt Damon film The Martian for an audience of over 20,000 loyal followers.”
INTERNET
The FCC Just Voted to Repeal Its Net Neutrality Rules, in a Sweeping Act of DeregulationBrian Fung | The Washington Post“The 3-2 vote, which was along party lines, enabled the FCC’s Republican chairman, AjitPai, to follow through on his promise to repeal the government’s 2015 net neutrality rules, which required Internet providers to treat all websites, large and small, equally.”
GENDER EQUALITY
Sexism’s National Reckoning and the Tech Women Who Blazed the TrailTekla S. Perry | IEEE Spectrum“Cassidy and other women in tech who spoke during the one-day event stressed that the watershed came not because women finally broke the silence about sexual harassment, whatever Time’s editors may believe. The change came because the women were finally listened to and the bad actors faced repercussions.”
FUTURE
These Technologies Will Shape the Future, According to One of Silicon Valley’s Top VC FirmsDaniel Terdiman | Fast Company“The question then, is what are the technologies that are going to drive the future. At Andreessen Horowitz, a picture of that future, at least the next 10 years or so, is coming into focus.During a recent firm summit, Evans laid out his vision for the most significant tech opportunities of the next decade.On the surface, the four areas he identifies–autonomy, mixed-reality, cryptocurrencies, and artificial intelligence–aren’t entirely surprises.”
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#430830 Biocomputers Made From Cells Can Now ...

When it comes to biomolecules, RNA doesn’t get a lot of love.
Maybe you haven’t even heard of the silent workhorse. RNA is the cell’s de facto translator: like a game of telephone, RNA takes DNA’s genetic code to a cellular factory called ribosomes. There, the cell makes proteins based on RNA’s message.
But RNA isn’t just a middleman. It controls what proteins are formed. Because proteins wiz around the cell completing all sorts of important processes, you can say that RNA is the gatekeeper: no RNA message, no proteins, no life.
In a new study published in Nature, RNA finally took center stage. By adding bits of genetic material to the E. Coli bacteria, a team of biohackers at the Wyss Institute hijacked the organism’s RNA messengers so that they only spring into action following certain inputs.
The result? A bacterial biocomputer capable of performing 12-input logic operations—AND, OR, and NOT—following specific inputs. Rather than outputting 0s and 1s, these biocircuits produce results based on the presence or absence of proteins and other molecules.
“It’s the greatest number of inputs in a circuit that a cell has been able to process,” says study author Dr. Alexander Green at Arizona State University. “To be able to analyze those signals and make a decision is the big advance here.”
When given a specific set of inputs, the bacteria spit out a protein that made them glow neon green under fluorescent light.
But synthetic biology promises far more than just a party trick—by tinkering with a cell’s RNA repertoire, scientists may one day coax them to photosynthesize, produce expensive drugs on the fly, or diagnose and hunt down rogue tumor cells.
Illustration of an RNA-based ‘ribocomputing’ device that makes logic-based decisions in living cells. The long gate RNA (blue) detects the binding of an input RNA (red). The ribosome (purple/mauve) reads the gate RNA to produce an output protein. Image Credit: Alexander Green / Arizona State University
The software of life
This isn’t the first time that scientists hijacked life’s algorithms to reprogram cells into nanocomputing systems. Previous work has already introduced to the world yeast cells that can make anti-malaria drugs from sugar or mammalian cells that can perform Boolean logic.
Yet circuits with multiple inputs and outputs remain hard to program. The reason is this: synthetic biologists have traditionally focused on snipping, fusing, or otherwise arranging a cell’s DNA to produce the outcomes they want.
But DNA is two steps removed from proteins, and tinkering with life’s code often leads to unexpected consequences. For one, the cell may not even accept and produce the extra bits of DNA code. For another, the added code, when transformed into proteins, may not act accordingly in the crowded and ever-changing environment of the cell.
What’s more, tinkering with one gene is often not enough to program an entirely new circuit. Scientists often need to amp up or shut down the activity of multiple genes, or multiple biological “modules” each made up of tens or hundreds of genes.
It’s like trying to fit new Lego pieces in a specific order into a room full of Lego constructions. Each new piece has the potential to wander off track and click onto something it’s not supposed to touch.
Getting every moving component to work in sync—as you might have guessed—is a giant headache.
The RNA way
With “ribocomputing,” Green and colleagues set off to tackle a main problem in synthetic biology: predictability.
Named after the “R (ribo)” in “RNA,” the method grew out of an idea that first struck Green back in 2012.
“The synthetic biological circuits to date have relied heavily on protein-based regulators that are difficult to scale up,” Green wrote at the time. We only have a limited handful of “designable parts” that work well, and these circuits require significant resources to encode and operate, he explains.
RNA, in comparison, is a lot more predictable. Like its more famous sibling DNA, RNA is composed of units that come in four different flavors: A, G, C, and U. Although RNA is only single-stranded, rather than the double helix for which DNA is known for, it can bind short DNA-like sequences in a very predictable manner: Gs always match up with Cs and As always with Us.
Because of this predictability, it’s possible to design RNA components that bind together perfectly. In other words, it reduces the chance that added RNA bits might go rogue in an unsuspecting cell.
Normally, once RNA is produced it immediately rushes to the ribosome—the cell’s protein-building factory. Think of it as a constantly “on” system.
However, Green and his team found a clever mechanism to slow them down. Dubbed the “toehold switch,” it works like this: the artificial RNA component is first incorporated into a chain of A, G, C, and U folded into a paperclip-like structure.
This blocks the RNA from accessing the ribosome. Because one RNA strand generally maps to one protein, the switch prevents that protein from ever getting made.
In this way, the switch is set to “off” by default—a “NOT” gate, in Boolean logic.
To activate the switch, the cell needs another component: a “trigger RNA,” which binds to the RNA toehold switch. This flips it on: the RNA grabs onto the ribosome, and bam—proteins.
BioLogic gates
String a few RNA switches together, with the activity of each one relying on the one before, and it forms an “AND” gate. Alternatively, if the activity of each switch is independent, that’s an “OR” gate.
“Basically, the toehold switches performed so well that we wanted to find a way to best exploit them for cellular applications,” says Green. They’re “kind of the equivalent of your first transistors,” he adds.
Once the team optimized the designs for different logic gates, they carefully condensed the switches into “gate RNA” molecules. These gate RNAs contain both codes for proteins and the logic operations needed to kickstart the process—a molecular logic circuit, so to speak.
If you’ve ever played around with an Arduino-controlled electrical circuit, you probably know the easiest way to test its function is with a light bulb.
That’s what the team did here, though with a biological bulb: green fluorescent protein, a light-sensing protein not normally present in bacteria that—when turned on—makes the microbugs glow neon green.
In a series of experiments, Green and his team genetically inserted gate RNAs into bacteria. Then, depending on the type of logical function, they added different combinations of trigger RNAs—the inputs.
When the input RNA matched up with its corresponding gate RNA, it flipped on the switch, causing the cell to light up.

Their most complex circuit contained five AND gates, five OR gates, and two NOTs—a 12-input ribocomputer that functioned exactly as designed.
That’s quite the achievement. “Everything is interacting with everything else and there are a million ways those interactions could flip the switch on accident,” says RNA researcher Dr. Julies Lucks at Northwestern University.
The specificity is thanks to RNA, the authors explain. Because RNAs bind to others so predictably, we can now design massive libraries of gate and trigger units to mix-and-match into all types of nano-biocomputers.
RNA BioNanobots
Although the technology doesn’t have any immediate applications, the team has high hopes.
For the first time, it’s now possible to massively scale up the process of programming new circuits into living cells. We’ve expanded the library of available biocomponents that can be used to reprogram life’s basic code, the authors say.
What’s more, when freeze-dried onto a piece of tissue paper, RNA keeps very well. We could potentially print RNA toehold switches onto paper that respond to viruses or to tumor cells, the authors say, essentially transforming the technology into highly accurate diagnostic platforms.
But Green’s hopes are even wilder for his RNA-based circuits.
“Because we’re using RNA, a universal molecule of life, we know these interactions can also work in other cells, so our method provides a general strategy that could be ported to other organisms,” he says.
Ultimately, the hope is to program neural network-like capabilities into the body’s other cells.
Imagine cells endowed with circuits capable of performing the kinds of computation the brain does, the authors say.
Perhaps one day, synthetic biology will transform our own cells into fully programmable entities, turning us all into biological cyborgs from the inside. How wild would that be?
Image Credit: Wyss Institute at Harvard University Continue reading

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