Tag Archives: gene
Gene Therapy Might Have Its First Blockbuster
Antonio Regalado | MIT Technology Review
“…drug giant Novartis expects to win approval to launch what it says will be the first ‘blockbuster’ gene-replacement treatment. A blockbuster is any drug with more than $1 billion in sales each year. The treatment, called Zolgensma, is able to save infants born with spinal muscular atrophy (SMA) type 1, a degenerative disease that usually kills within two years.”
AI Took a Test to Detect Lung Cancer. It Got an A.
Denise Grady | The New York Times
“Computers were as good or better than doctors at detecting tiny lung cancers on CT scans, in a study by researchers from Google and several medical centers. The technology is a work in progress, not ready for widespread use, but the new report, published Monday in the journal Nature Medicine, offers a glimpse of the future of artificial intelligence in medicine.”
The Rise and Reign of Starship, the World’s First Robotic Delivery Provider
Luke Dormehl | Digital Trends
“[Starship’s] delivery robots have travelled a combined 200,000 miles, carried out 50,000 deliveries, and been tested in over 100 cities in 20 countries. It is a regular fixture not just in multiple neighborhoods but also university campuses.”
Elon Musk Just Ignited the Race to Build the Space Internet
Jonathan O’Callaghan | Wired
“It’s estimated that about 3.3 billion people lack access to the internet, but Elon Musk is trying to change that. On Thursday, May 23—after two cancelled launches the week before—SpaceX launched 60 Starlink satellites on a Falcon 9 rocket from Cape Canaveral, in Florida, as part of the firm’s mission to bring low-cost, high-speed internet to the world.”
The iPod of VR Is Here, and You Should Try It
Mark Wilson | Fast Company
“In nearly 15 years of writing about cutting-edge technology, I’ve never seen a single product line get so much better so fast. With [the Oculus] Quest, there are no PCs required. There are no wires to run. All you do is grab the cloth headset and pull it around your head.”
FUTURE OF FOOD
Impossible Foods’ Rising Empire of Almost Meat
Chris Ip | Engadget
“Impossible says it wants to ultimately create a parallel universe of ersatz animal products from steak to eggs. …Yet as Impossible ventures deeper into the culinary uncanny valley, it also needs society to discard a fundamental cultural idea that dates back millennia and accept a new truth: Meat doesn’t have to come from animals.”
Can We Live Longer but Stay Younger?
Adam Gopnik | The New Yorker
“With greater longevity, the quest to avoid the infirmities of aging is more urgent than ever.”
Facial Recognition Has Already Reached Its Breaking Point
Lily Hay Newman | Wired
“As facial recognition technologies have evolved from fledgling projects into powerful software platforms, researchers and civil liberties advocates have been issuing warnings about the potential for privacy erosions. Those mounting fears came to a head Wednesday in Congress.”
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The Microbots Are on Their Way
Kenneth Chang | The New York Times
“Like Frankenstein, Marc Miskin’s robots initially lie motionless. Then their limbs jerk to life. But these robots are the size of a speck of dust. Thousands fit side-by-side on a single silicon wafer similar to those used for computer chips, and, like Frankenstein coming to life, they pull themselves free and start crawling.”
Why the ‘Post-Natural’ Age Could Be Strange and Beautiful
Lauren Holt | BBC
“As long as humans have existed, we have been influencing our planet’s flora and fauna. So, if humanity continues to flourish far into the future, how will nature change? And how might this genetic manipulation affect our own biology and evolutionary trajectory? The short answer: it will be strange, potentially beautiful and like nothing we’re used to.”
Watch This Wild 3D-Printed Lung Air Sac Breathe
Amanda Kooser | CNET
“A research team led by bioengineers at the University of Washington and Rice University developed an open-source technique for bioprinting tissues ‘with exquisitely entangled vascular networks similar to the body’s natural passageways for blood, air, lymph and other vital fluids.’i”
A New Camera Can Photograph You From 45 Kilometers Away
Emerging Technology from the arXiv | MIT Technology Review
“Conventional images taken through the telescope show nothing other than noise. But the new technique produces images with a spatial resolution of about 60 cm, which resolves building windows.”
The Search for the Kryptonite That Can Stop CRISPR
Antonio Regalado | MIT Technology Review
“CRISPR weapons? We’ll leave it to your imagination exactly what one could look like. What is safe to say, though, is that DARPA has asked Doudna and others to start looking into prophylactic treatments or even pills you could take to stop gene editing, just the way you can swallow antibiotics if you’ve gotten an anthrax letter in the mail.”
The Holy Grail of Robotics: Inside the Quest to Build a Mechanical Human Hand
Luke Dormehl | Digital Trends
“For real-life roboticists, building the perfect robot hand has long been the Holy Grail. It is the hardware yin to the software yang of creating an artificial mind. Seeking out the ultimate challenge, robotics experts gravitated to recreating what is one of the most complicated and beautiful pieces of natural engineering found in the human body.”
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Spider-Man is one of the most popular superheroes of all time. It’s a bit surprising given that one of the more common phobias is arachnophobia—a debilitating fear of spiders.
Perhaps more fantastical is that young Peter Parker, a brainy high school science nerd, seemingly developed overnight the famous web-shooters and the synthetic spider silk that he uses to swing across the cityscape like Tarzan through the jungle.
That’s because scientists have been trying for decades to replicate spider silk, a material that is five times stronger than steel, among its many superpowers. In recent years, researchers have been untangling the protein-based fiber’s structure down to the molecular level, leading to new insights and new potential for eventual commercial uses.
The applications for such a material seem near endless. There’s the more futuristic visions, like enabling robotic “muscles” for human-like movement or ensnaring real-life villains with a Spider-Man-like web. Near-term applications could include the biomedical industry, such as bandages and adhesives, and as a replacement textile for everything from rope to seat belts to parachutes.
Spinning Synthetic Spider Silk
Randy Lewis has been studying the properties of spider silk and developing methods for producing it synthetically for more than three decades. In the 1990s, his research team was behind cloning the first spider silk gene, as well as the first to identify and sequence the proteins that make up the six different silks that web slingers make. Each has different mechanical properties.
“So our thought process was that you could take that information and begin to to understand what made them strong and what makes them stretchy, and why some are are very stretchy and some are not stretchy at all, and some are stronger and some are weaker,” explained Lewis, a biology professor at Utah State University and director of the Synthetic Spider Silk Lab, in an interview with Singularity Hub.
Spiders are naturally territorial and cannibalistic, so any intention to farm silk naturally would likely end in an orgy of arachnid violence. Instead, Lewis and company have genetically modified different organisms to produce spider silk synthetically, including inserting a couple of web-making genes into the genetic code of goats. The goats’ milk contains spider silk proteins.
The lab also produces synthetic spider silk through a fermentation process not entirely dissimilar to brewing beer, but using genetically modified bacteria to make the desired spider silk proteins. A similar technique has been used for years to make a key enzyme in cheese production. More recently, companies are using transgenic bacteria to make meat and milk proteins, entirely bypassing animals in the process.
The same fermentation technology is used by a chic startup called Bolt Threads outside of San Francisco that has raised more than $200 million for fashionable fibers made out of synthetic spider silk it calls Microsilk. (The company is also developing a second leather-like material, Mylo, using the underground root structure of mushrooms known as mycelium.)
Lewis’ lab also uses transgenic silkworms to produce a kind of composite material made up of the domesticated insect’s own silk proteins and those of spider silk. “Those have some fairly impressive properties,” Lewis said.
The researchers are even experimenting with genetically modified alfalfa. One of the big advantages there is that once the spider silk protein has been extracted, the remaining protein could be sold as livestock feed. “That would bring the cost of spider silk protein production down significantly,” Lewis said.
Building a Better Web
Producing synthetic spider silk isn’t the problem, according to Lewis, but the ability to do it at scale commercially remains a sticking point.
Another challenge is “weaving” the synthetic spider silk into usable products that can take advantage of the material’s marvelous properties.
“It is possible to make silk proteins synthetically, but it is very hard to assemble the individual proteins into a fiber or other material forms,” said Markus Buehler, head of the Department of Civil and Environmental Engineering at MIT, in an email to Singularity Hub. “The spider has a complex spinning duct in which silk proteins are exposed to physical forces, chemical gradients, the combination of which generates the assembly of molecules that leads to silk fibers.”
Buehler recently co-authored a paper in the journal Science Advances that found dragline spider silk exhibits different properties in response to changes in humidity that could eventually have applications in robotics.
Specifically, spider silk suddenly contracts and twists above a certain level of relative humidity, exerting enough force to “potentially be competitive with other materials being explored as actuators—devices that move to perform some activity such as controlling a valve,” according to a press release.
Studying Spider Silk Up Close
Recent studies at the molecular level are helping scientists learn more about the unique properties of spider silk, which may help researchers develop materials with extraordinary capabilities.
For example, scientists at Arizona State University used magnetic resonance tools and other instruments to image the abdomen of a black widow spider. They produced what they called the first molecular-level model of spider silk protein fiber formation, providing insights on the nanoparticle structure. The research was published last October in Proceedings of the National Academy of Sciences.
A cross section of the abdomen of a black widow (Latrodectus Hesperus) spider used in this study at Arizona State University. Image Credit: Samrat Amin.
Also in 2018, a study presented in Nature Communications described a sort of molecular clamp that binds the silk protein building blocks, which are called spidroins. The researchers observed for the first time that the clamp self-assembles in a two-step process, contributing to the extensibility, or stretchiness, of spider silk.
Another team put the spider silk of a brown recluse under an atomic force microscope, discovering that each strand, already 1,000 times thinner than a human hair, is made up of thousands of nanostrands. That helps explain its extraordinary tensile strength, though technique is also a factor, as the brown recluse uses a special looping method to reinforce its silk strands. The study also appeared last year in the journal ACS Macro Letters.
Making Spider Silk Stick
Buehler said his team is now trying to develop better and faster predictive methods to design silk proteins using artificial intelligence.
“These new methods allow us to generate new protein designs that do not naturally exist and which can be explored to optimize certain desirable properties like torsional actuation, strength, bioactivity—for example, tissue engineering—and others,” he said.
Meanwhile, Lewis’ lab has discovered a method that allows it to solubilize spider silk protein in what is essentially a water-based solution, eschewing acids or other toxic compounds that are normally used in the process.
That enables the researchers to develop materials beyond fiber, including adhesives that “are better than an awful lot of the current commercial adhesives,” Lewis said, as well as coatings that could be used to dampen vibrations, for example.
“We’re making gels for various kinds of of tissue regeneration, as well as drug delivery, and things like that,” he added. “So we’ve expanded the use profile from something beyond fibers to something that is a much more extensive portfolio of possible kinds of materials.”
And, yes, there’s even designs at the Synthetic Spider Silk Lab for developing a Spider-Man web-slinger material. The US Navy is interested in non-destructive ways of disabling an enemy vessel, such as fouling its propeller. The project also includes producing synthetic proteins from the hagfish, an eel-like critter that exudes a gelatinous slime when threatened.
Lewis said that while the potential for spider silk is certainly headline-grabbing, he cautioned that much of the hype is not focused on the unique mechanical properties that could lead to advances in healthcare and other industries.
“We want to see spider silk out there because it’s a unique material, not because it’s got marketing appeal,” he said.
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