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#432027 We Read This 800-Page Report on the ...

The longevity field is bustling but still fragmented, and the “silver tsunami” is coming.

That is the takeaway of The Science of Longevity, the behemoth first volume of a four-part series offering a bird’s-eye view of the longevity industry in 2017. The report, a joint production of the Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International, synthesizes the growing array of academic and industry ventures related to aging, healthspan, and everything in between.

This is huge, not only in scale but also in ambition. The report, totally worth a read here, will be followed by four additional volumes in 2018, covering topics ranging from the business side of longevity ventures to financial systems to potential tensions between life extension and religion.

And that’s just the first step. The team hopes to publish updated versions of the report annually, giving scientists, investors, and regulatory agencies an easy way to keep their finger on the longevity pulse.

“In 2018, ‘aging’ remains an unnamed adversary in an undeclared war. For all intents and purposes it is mere abstraction in the eyes of regulatory authorities worldwide,” the authors write.

That needs to change.

People often arrive at the field of aging from disparate areas with wildly diverse opinions and strengths. The report compiles these individual efforts at cracking aging into a systematic resource—a “periodic table” for longevity that clearly lays out emerging trends and promising interventions.

The ultimate goal? A global framework serving as a road map to guide the burgeoning industry. With such a framework in hand, academics and industry alike are finally poised to petition the kind of large-scale investments and regulatory changes needed to tackle aging with a unified front.

Infographic depicting many of the key research hubs and non-profits within the field of geroscience.
Image Credit: Longevity.International
The Aging Globe
The global population is rapidly aging. And our medical and social systems aren’t ready to handle this oncoming “silver tsunami.”

Take the medical field. Many age-related diseases such as Alzheimer’s lack effective treatment options. Others, including high blood pressure, stroke, lung or heart problems, require continuous medication and monitoring, placing enormous strain on medical resources.

What’s more, because disease risk rises exponentially with age, medical care for the elderly becomes a game of whack-a-mole: curing any individual disease such as cancer only increases healthy lifespan by two to three years before another one hits.

That’s why in recent years there’s been increasing support for turning the focus to the root of the problem: aging. Rather than tackling individual diseases, geroscience aims to add healthy years to our lifespan—extending “healthspan,” so to speak.

Despite this relative consensus, the field still faces a roadblock. The US FDA does not yet recognize aging as a bona fide disease. Without such a designation, scientists are banned from testing potential interventions for aging in clinical trials (that said, many have used alternate measures such as age-related biomarkers or Alzheimer’s symptoms as a proxy).

Luckily, the FDA’s stance is set to change. The promising anti-aging drug metformin, for example, is already in clinical trials, examining its effect on a variety of age-related symptoms and diseases. This report, and others to follow, may help push progress along.

“It is critical for investors, policymakers, scientists, NGOs, and influential entities to prioritize the amelioration of the geriatric world scenario and recognize aging as a critical matter of global economic security,” the authors say.

Biomedical Gerontology
The causes of aging are complex, stubborn, and not all clear.

But the report lays out two main streams of intervention with already promising results.

The first is to understand the root causes of aging and stop them before damage accumulates. It’s like meddling with cogs and other inner workings of a clock to slow it down, the authors say.

The report lays out several treatments to keep an eye on.

Geroprotective drugs is a big one. Often repurposed from drugs already on the market, these traditional small molecule drugs target a wide variety of metabolic pathways that play a role in aging. Think anti-oxidants, anti-inflammatory, and drugs that mimic caloric restriction, a proven way to extend healthspan in animal models.

More exciting are the emerging technologies. One is nanotechnology. Nanoparticles of carbon, “bucky-balls,” for example, have already been shown to fight viral infections and dangerous ion particles, as well as stimulate the immune system and extend lifespan in mice (though others question the validity of the results).

Blood is another promising, if surprising, fountain of youth: recent studies found that molecules in the blood of the young rejuvenate the heart, brain, and muscles of aged rodents, though many of these findings have yet to be replicated.

Rejuvenation Biotechnology
The second approach is repair and maintenance.

Rather than meddling with inner clockwork, here we force back the hands of a clock to set it back. The main example? Stem cell therapy.

This type of approach would especially benefit the brain, which harbors small, scattered numbers of stem cells that deplete with age. For neurodegenerative diseases like Alzheimer’s, in which neurons progressively die off, stem cell therapy could in theory replace those lost cells and mend those broken circuits.

Once a blue-sky idea, the discovery of induced pluripotent stem cells (iPSCs), where scientists can turn skin and other mature cells back into a stem-like state, hugely propelled the field into near reality. But to date, stem cells haven’t been widely adopted in clinics.

It’s “a toolkit of highly innovative, highly invasive technologies with clinical trials still a great many years off,” the authors say.

But there is a silver lining. The boom in 3D tissue printing offers an alternative approach to stem cells in replacing aging organs. Recent investment from the Methuselah Foundation and other institutions suggests interest remains high despite still being a ways from mainstream use.

A Disruptive Future
“We are finally beginning to see an industry emerge from mankind’s attempts to make sense of the biological chaos,” the authors conclude.

Looking through the trends, they identified several technologies rapidly gaining steam.

One is artificial intelligence, which is already used to bolster drug discovery. Machine learning may also help identify new longevity genes or bring personalized medicine to the clinic based on a patient’s records or biomarkers.

Another is senolytics, a class of drugs that kill off “zombie cells.” Over 10 prospective candidates are already in the pipeline, with some expected to enter the market in less than a decade, the authors say.

Finally, there’s the big gun—gene therapy. The treatment, unlike others mentioned, can directly target the root of any pathology. With a snip (or a swap), genetic tools can turn off damaging genes or switch on ones that promote a youthful profile. It is the most preventative technology at our disposal.

There have already been some success stories in animal models. Using gene therapy, rodents given a boost in telomerase activity, which lengthens the protective caps of DNA strands, live healthier for longer.

“Although it is the prospect farthest from widespread implementation, it may ultimately prove the most influential,” the authors say.

Ultimately, can we stop the silver tsunami before it strikes?

Perhaps not, the authors say. But we do have defenses: the technologies outlined in the report, though still immature, could one day stop the oncoming tidal wave in its tracks.

Now we just have to bring them out of the lab and into the real world. To push the transition along, the team launched Longevity.International, an online meeting ground that unites various stakeholders in the industry.

By providing scientists, entrepreneurs, investors, and policy-makers a platform for learning and discussion, the authors say, we may finally generate enough drive to implement our defenses against aging. The war has begun.

Read the report in full here, and watch out for others coming soon here. The second part of the report profiles 650 (!!!) longevity-focused research hubs, non-profits, scientists, conferences, and literature. It’s an enormously helpful resource—totally worth keeping it in your back pocket for future reference.

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#431995 The 10 Grand Challenges Facing Robotics ...

Robotics research has been making great strides in recent years, but there are still many hurdles to the machines becoming a ubiquitous presence in our lives. The journal Science Robotics has now identified 10 grand challenges the field will have to grapple with to make that a reality.

Editors conducted an online survey on unsolved challenges in robotics and assembled an expert panel of roboticists to shortlist the 30 most important topics, which were then grouped into 10 grand challenges that could have major impact in the next 5 to 10 years. Here’s what they came up with.

1. New Materials and Fabrication Schemes
Roboticists are beginning to move beyond motors, gears, and sensors by experimenting with things like artificial muscles, soft robotics, and new fabrication methods that combine multiple functions in one material. But most of these advances have been “one-off” demonstrations, which are not easy to combine.

Multi-functional materials merging things like sensing, movement, energy harvesting, or energy storage could allow more efficient robot designs. But combining these various properties in a single machine will require new approaches that blend micro-scale and large-scale fabrication techniques. Another promising direction is materials that can change over time to adapt or heal, but this requires much more research.

2. Bioinspired and Bio-Hybrid Robots
Nature has already solved many of the problems roboticists are trying to tackle, so many are turning to biology for inspiration or even incorporating living systems into their robots. But there are still major bottlenecks in reproducing the mechanical performance of muscle and the ability of biological systems to power themselves.

There has been great progress in artificial muscles, but their robustness, efficiency, and energy and power density need to be improved. Embedding living cells into robots can overcome challenges of powering small robots, as well as exploit biological features like self-healing and embedded sensing, though how to integrate these components is still a major challenge. And while a growing “robo-zoo” is helping tease out nature’s secrets, more work needs to be done on how animals transition between capabilities like flying and swimming to build multimodal platforms.

3. Power and Energy
Energy storage is a major bottleneck for mobile robotics. Rising demand from drones, electric vehicles, and renewable energy is driving progress in battery technology, but the fundamental challenges have remained largely unchanged for years.

That means that in parallel to battery development, there need to be efforts to minimize robots’ power utilization and give them access to new sources of energy. Enabling them to harvest energy from their environment and transmitting power to them wirelessly are two promising approaches worthy of investigation.

4. Robot Swarms
Swarms of simple robots that assemble into different configurations to tackle various tasks can be a cheaper, more flexible alternative to large, task-specific robots. Smaller, cheaper, more powerful hardware that lets simple robots sense their environment and communicate is combining with AI that can model the kind of behavior seen in nature’s flocks.

But there needs to be more work on the most efficient forms of control at different scales—small swarms can be controlled centrally, but larger ones need to be more decentralized. They also need to be made robust and adaptable to the changing conditions of the real world and resilient to deliberate or accidental damage. There also needs to be more work on swarms of non-homogeneous robots with complementary capabilities.

5. Navigation and Exploration
A key use case for robots is exploring places where humans cannot go, such as the deep sea, space, or disaster zones. That means they need to become adept at exploring and navigating unmapped, often highly disordered and hostile environments.

The major challenges include creating systems that can adapt, learn, and recover from navigation failures and are able to make and recognize new discoveries. This will require high levels of autonomy that allow the robots to monitor and reconfigure themselves while being able to build a picture of the world from multiple data sources of varying reliability and accuracy.

6. AI for Robotics
Deep learning has revolutionized machines’ ability to recognize patterns, but that needs to be combined with model-based reasoning to create adaptable robots that can learn on the fly.

Key to this will be creating AI that’s aware of its own limitations and can learn how to learn new things. It will also be important to create systems that are able to learn quickly from limited data rather than the millions of examples used in deep learning. Further advances in our understanding of human intelligence will be essential to solving these problems.

7. Brain-Computer Interfaces
BCIs will enable seamless control of advanced robotic prosthetics but could also prove a faster, more natural way to communicate instructions to robots or simply help them understand human mental states.

Most current approaches to measuring brain activity are expensive and cumbersome, though, so work on compact, low-power, and wireless devices will be important. They also tend to involve extended training, calibration, and adaptation due to the imprecise nature of reading brain activity. And it remains to be seen if they will outperform simpler techniques like eye tracking or reading muscle signals.

8. Social Interaction
If robots are to enter human environments, they will need to learn to deal with humans. But this will be difficult, as we have very few concrete models of human behavior and we are prone to underestimate the complexity of what comes naturally to us.

Social robots will need to be able to perceive minute social cues like facial expression or intonation, understand the cultural and social context they are operating in, and model the mental states of people they interact with to tailor their dealings with them, both in the short term and as they develop long-standing relationships with them.

9. Medical Robotics
Medicine is one of the areas where robots could have significant impact in the near future. Devices that augment a surgeon’s capabilities are already in regular use, but the challenge will be to increase the autonomy of these systems in such a high-stakes environment.

Autonomous robot assistants will need to be able to recognize human anatomy in a variety of contexts and be able to use situational awareness and spoken commands to understand what’s required of them. In surgery, autonomous robots could perform the routine steps of a procedure, giving way to the surgeon for more complicated patient-specific bits.

Micro-robots that operate inside the human body also hold promise, but there are still many roadblocks to their adoption, including effective delivery systems, tracking and control methods, and crucially, finding therapies where they improve on current approaches.

10. Robot Ethics and Security
As the preceding challenges are overcome and robots are increasingly integrated into our lives, this progress will create new ethical conundrums. Most importantly, we may become over-reliant on robots.

That could lead to humans losing certain skills and capabilities, making us unable to take the reins in the case of failures. We may end up delegating tasks that should, for ethical reasons, have some human supervision, and allow people to pass the buck to autonomous systems in the case of failure. It could also reduce self-determination, as human behaviors change to accommodate the routines and restrictions required for robots and AI to work effectively.

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#431958 The Next Generation of Cameras Might See ...

You might be really pleased with the camera technology in your latest smartphone, which can recognize your face and take slow-mo video in ultra-high definition. But these technological feats are just the start of a larger revolution that is underway.

The latest camera research is shifting away from increasing the number of mega-pixels towards fusing camera data with computational processing. By that, we don’t mean the Photoshop style of processing where effects and filters are added to a picture, but rather a radical new approach where the incoming data may not actually look like at an image at all. It only becomes an image after a series of computational steps that often involve complex mathematics and modeling how light travels through the scene or the camera.

This additional layer of computational processing magically frees us from the chains of conventional imaging techniques. One day we may not even need cameras in the conventional sense any more. Instead we will use light detectors that only a few years ago we would never have considered any use for imaging. And they will be able to do incredible things, like see through fog, inside the human body and even behind walls.

Single Pixel Cameras
One extreme example is the single pixel camera, which relies on a beautifully simple principle. Typical cameras use lots of pixels (tiny sensor elements) to capture a scene that is likely illuminated by a single light source. But you can also do things the other way around, capturing information from many light sources with a single pixel.

To do this you need a controlled light source, for example a simple data projector that illuminates the scene one spot at a time or with a series of different patterns. For each illumination spot or pattern, you then measure the amount of light reflected and add everything together to create the final image.

Clearly the disadvantage of taking a photo in this is way is that you have to send out lots of illumination spots or patterns in order to produce one image (which would take just one snapshot with a regular camera). But this form of imaging would allow you to create otherwise impossible cameras, for example that work at wavelengths of light beyond the visible spectrum, where good detectors cannot be made into cameras.

These cameras could be used to take photos through fog or thick falling snow. Or they could mimic the eyes of some animals and automatically increase an image’s resolution (the amount of detail it captures) depending on what’s in the scene.

It is even possible to capture images from light particles that have never even interacted with the object we want to photograph. This would take advantage of the idea of “quantum entanglement,” that two particles can be connected in a way that means whatever happens to one happens to the other, even if they are a long distance apart. This has intriguing possibilities for looking at objects whose properties might change when lit up, such as the eye. For example, does a retina look the same when in darkness as in light?

Multi-Sensor Imaging
Single-pixel imaging is just one of the simplest innovations in upcoming camera technology and relies, on the face of it, on the traditional concept of what forms a picture. But we are currently witnessing a surge of interest for systems that use lots of information but traditional techniques only collect a small part of it.

This is where we could use multi-sensor approaches that involve many different detectors pointed at the same scene. The Hubble telescope was a pioneering example of this, producing pictures made from combinations of many different images taken at different wavelengths. But now you can buy commercial versions of this kind of technology, such as the Lytro camera that collects information about light intensity and direction on the same sensor, to produce images that can be refocused after the image has been taken.

The next generation camera will probably look something like the Light L16 camera, which features ground-breaking technology based on more than ten different sensors. Their data are combined using a computer to provide a 50 MB, re-focusable and re-zoomable, professional-quality image. The camera itself looks like a very exciting Picasso interpretation of a crazy cell-phone camera.

Yet these are just the first steps towards a new generation of cameras that will change the way in which we think of and take images. Researchers are also working hard on the problem of seeing through fog, seeing behind walls, and even imaging deep inside the human body and brain.

All of these techniques rely on combining images with models that explain how light travels through through or around different substances.

Another interesting approach that is gaining ground relies on artificial intelligence to “learn” to recognize objects from the data. These techniques are inspired by learning processes in the human brain and are likely to play a major role in future imaging systems.

Single photon and quantum imaging technologies are also maturing to the point that they can take pictures with incredibly low light levels and videos with incredibly fast speeds reaching a trillion frames per second. This is enough to even capture images of light itself traveling across as scene.

Some of these applications might require a little time to fully develop, but we now know that the underlying physics should allow us to solve these and other problems through a clever combination of new technology and computational ingenuity.

This article was originally published on The Conversation. Read the original article.

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#431939 This Awesome Robot Is the Size of a ...

They say size isn’t everything, but when it comes to delta robots it seems like it’s pretty important.

The speed and precision of these machines sees them employed in delicate pick-and-place tasks in all kinds of factories, as well as to control 3D printer heads. But Harvard researchers have found that scaling them down to millimeter scale makes them even faster and more precise, opening up applications in everything from microsurgery to manipulating tiny objects like circuit board components or even living cells.

Unlike the industrial robots you’re probably more familiar with, delta robots consist of three individually controlled arms supporting a platform. Different combinations of movements can move the platform in three directions, and a variety of tools can be attached to this platform.



The benefit of this design is that unlike a typical robotic arm, all the motors are housed at the base rather than at the joints, which reduces their mechanical complexity, but also—importantly—the weight of the arms. That means they can move and accelerate faster and with greater precision.

It’s been known for a while that the physics of these robots means the smaller you can make them, the more pronounced these advantages become, but scientists had struggled to build them at scales below tens of centimeters.

In a recent paper in the journal Science Robotics, the researchers describe how they used an origami-inspired micro-fabrication approach that relies on folding flat sheets of composite materials to create a robot measuring just 15 millimeters by 15 millimeters by 20 millimeters.

The robot dubbed “milliDelta” features joints that rely on a flexible polymer core to bend—a simplified version of the more complicated joints found in large-scale delta robots. The machine was powered by three piezoelectric actuators, which flex when a voltage is applied, and could perform movements at frequencies 15 to 20 times higher than current delta robots, with precisions down to roughly 5 micrometers.

One potential use for the device is to cancel out surgeons’ hand tremors as they carry out delicate microsurgery procedures, such as operations on the eye’s retina. The researchers actually investigated this application in their paper. They got volunteers to hold a toothpick and measured the movement of the tip to map natural hand tremors. They fed this data to the milliDelta, which was able to match the movements and therefore cancel them out.

In an email to Singularity Hub, the researchers said that adding the robot to the end of a surgical tool could make it possible to stabilize needles or scalpels, though this would require some design optimization. For a start, the base would have to be redesigned to fit on a surgical tool, and sensors would have to be added to the robot to allow it to measure tremors in real time.

Another promising application for the device would be placing components on circuit boards at very high speeds, which could prove valuable in electronics manufacturing. The researchers even think the device’s precision means it could be used for manipulating living cells in research and clinical laboratories.

The researchers even said it would be feasible to integrate the devices onto microrobots to give them similarly impressive manipulation capabilities, though that would require considerable work to overcome control and sensing challenges.

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#431862 Want Self-Healing Robots and Tires? ...

We all have scars, and each one tells a story. Tales of tomfoolery, tales of haphazardness, or in my case, tales of stupidity.
Whether the cause of your scar was a push-bike accident, a lack of concentration while cutting onions, or simply the byproduct of an active lifestyle, the experience was likely extremely painful and distressing. Not to mention the long and vexatious recovery period, stretching out for weeks and months after the actual event!
Cast your minds back to that time. How you longed for instant relief from your discomfort! How you longed to have your capabilities restored in an instant!
Well, materials that can heal themselves in an instant may not be far from becoming a reality—and a family of them known as elastomers holds the key.
“Elastomer” is essentially a big, fancy word for rubber. However, elastomers have one unique property—they are capable of returning to their original form after being vigorously stretched and deformed.
This unique property of elastomers has caught the eye of many scientists around the world, particularly those working in the field of robotics. The reason? Elastomer can be encouraged to return to its original shape, in many cases by simply applying heat. The implication of this is the quick and cost-effective repair of “wounds”—cuts, tears, and punctures to the soft, elastomer-based appendages of a robot’s exoskeleton.

Researchers from Vrije University in Brussels, Belgium have been toying with the technique, and with remarkable success. The team built a robotic hand with fingers made of a type of elastomer. They found that cuts and punctures were indeed able to repair themselves simply by applying heat to the affected area.
How long does the healing process take? In this instance, about a day. Now that’s a lot shorter than the weeks and months of recovery time we typically need for a flesh wound, during which we are unable to write, play the guitar, or do the dishes. If you consider the latter to be a bad thing…
However, it’s not the first time scientists have played around with elastomers and examined their self-healing properties. Another team of scientists, headed up by Cheng-Hui Li and Chao Wang, discovered another type of elastomer that exhibited autonomous self-healing properties. Just to help you picture this stuff, the material closely resembles animal muscle— strong, flexible, and elastic. With autogenetic restorative powers to boot.
Advancements in the world of self-healing elastomers, or rubbers, may also affect the lives of everyday motorists. Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a self-healing rubber material that could be used to make tires that repair their own punctures.
This time the mechanism of self-healing doesn’t involve heat. Rather, it is related to a physical phenomenon associated with the rubber’s unique structure. Normally, when a large enough stress is applied to a typical rubber, there is catastrophic failure at the focal point of that stress. The self-healing rubber the researchers created, on the other hand, distributes that same stress evenly over a network of “crazes”—which are like cracks connected by strands of fiber.
Here’s the interesting part. Not only does this unique physical characteristic of the rubber prevent catastrophic failure, it facilitates self-repair. According to Harvard researchers, when the stress is released, the material snaps back to its original form and the crazes heal.
This wonder material could be used in any number of rubber-based products.
Professor Jinrong Wu, of Sichuan University, China, and co-author of the study, happened to single out tires: “Imagine that we could use this material as one of the components to make a rubber tire… If you have a cut through the tire, this tire wouldn’t have to be replaced right away. Instead, it would self-heal while driving, enough to give you leeway to avoid dramatic damage,” said Wu.
So where to from here? Well, self-healing elastomers could have a number of different applications. According to the article published by Quartz, cited earlier, the material could be used on artificial limbs. Perhaps it will provide some measure of structural integrity without looking like a tattered mess after years of regular use.
Or perhaps a sort of elastomer-based hybrid skin is on the horizon. A skin in which wounds heal instantly. And recovery time, unlike your regular old human skin of yesteryear, is significantly slashed. Furthermore, this future skin might eliminate those little reminders we call scars.
For those with poor judgment skills, this spells an end to disquieting reminders of our own stupidity.
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