Tag Archives: cells

#436774 AI Is an Energy-Guzzler. We Need to ...

There is a saying that has emerged among the tech set in recent years: AI is the new electricity. The platitude refers to the disruptive power of artificial intelligence for driving advances in everything from transportation to predicting the weather.

Of course, the computers and data centers that support AI’s complex algorithms are very much dependent on electricity. While that may seem pretty obvious, it may be surprising to learn that AI can be extremely power-hungry, especially when it comes to training the models that enable machines to recognize your face in a photo or for Alexa to understand a voice command.

The scale of the problem is difficult to measure, but there have been some attempts to put hard numbers on the environmental cost.

For instance, one paper published on the open-access repository arXiv claimed that the carbon emissions for training a basic natural language processing (NLP) model—algorithms that process and understand language-based data—are equal to the CO2 produced by the average American lifestyle over two years. A more robust model required the equivalent of about 17 years’ worth of emissions.

The authors noted that about a decade ago, NLP models could do the job on a regular commercial laptop. Today, much more sophisticated AI models use specialized hardware like graphics processing units, or GPUs, a chip technology popularized by Nvidia for gaming that also proved capable of supporting computing tasks for AI.

OpenAI, a nonprofit research organization co-founded by tech prophet and profiteer Elon Musk, said that the computing power “used in the largest AI training runs has been increasing exponentially with a 3.4-month doubling time” since 2012. That’s about the time that GPUs started making their way into AI computing systems.

Getting Smarter About AI Chip Design
While GPUs from Nvidia remain the gold standard in AI hardware today, a number of startups have emerged to challenge the company’s industry dominance. Many are building chipsets designed to work more like the human brain, an area that’s been dubbed neuromorphic computing.

One of the leading companies in this arena is Graphcore, a UK startup that has raised more than $450 million and boasts a valuation of $1.95 billion. The company’s version of the GPU is an IPU, which stands for intelligence processing unit.

To build a computer brain more akin to a human one, the big brains at Graphcore are bypassing the precise but time-consuming number-crunching typical of a conventional microprocessor with one that’s content to get by on less precise arithmetic.

The results are essentially the same, but IPUs get the job done much quicker. Graphcore claimed it was able to train the popular BERT NLP model in just 56 hours, while tripling throughput and reducing latency by 20 percent.

An article in Bloomberg compared the approach to the “human brain shifting from calculating the exact GPS coordinates of a restaurant to just remembering its name and neighborhood.”

Graphcore’s hardware architecture also features more built-in memory processing, boosting efficiency because there’s less need to send as much data back and forth between chips. That’s similar to an approach adopted by a team of researchers in Italy that recently published a paper about a new computing circuit.

The novel circuit uses a device called a memristor that can execute a mathematical function known as a regression in just one operation. The approach attempts to mimic the human brain by processing data directly within the memory.

Daniele Ielmini at Politecnico di Milano, co-author of the Science Advances paper, told Singularity Hub that the main advantage of in-memory computing is the lack of any data movement, which is the main bottleneck of conventional digital computers, as well as the parallel processing of data that enables the intimate interactions among various currents and voltages within the memory array.

Ielmini explained that in-memory computing can have a “tremendous impact on energy efficiency of AI, as it can accelerate very advanced tasks by physical computation within the memory circuit.” He added that such “radical ideas” in hardware design will be needed in order to make a quantum leap in energy efficiency and time.

It’s Not Just a Hardware Problem
The emphasis on designing more efficient chip architecture might suggest that AI’s power hunger is essentially a hardware problem. That’s not the case, Ielmini noted.

“We believe that significant progress could be made by similar breakthroughs at the algorithm and dataset levels,” he said.

He’s not the only one.

One of the key research areas at Qualcomm’s AI research lab is energy efficiency. Max Welling, vice president of Qualcomm Technology R&D division, has written about the need for more power-efficient algorithms. He has gone so far as to suggest that AI algorithms will be measured by the amount of intelligence they provide per joule.

One emerging area being studied, Welling wrote, is the use of Bayesian deep learning for deep neural networks.

It’s all pretty heady stuff and easily the subject of a PhD thesis. The main thing to understand in this context is that Bayesian deep learning is another attempt to mimic how the brain processes information by introducing random values into the neural network. A benefit of Bayesian deep learning is that it compresses and quantifies data in order to reduce the complexity of a neural network. In turn, that reduces the number of “steps” required to recognize a dog as a dog—and the energy required to get the right result.

A team at Oak Ridge National Laboratory has previously demonstrated another way to improve AI energy efficiency by converting deep learning neural networks into what’s called a spiking neural network. The researchers spiked their deep spiking neural network (DSNN) by introducing a stochastic process that adds random values like Bayesian deep learning.

The DSNN actually imitates the way neurons interact with synapses, which send signals between brain cells. Individual “spikes” in the network indicate where to perform computations, lowering energy consumption because it disregards unnecessary computations.

The system is being used by cancer researchers to scan millions of clinical reports to unearth insights on causes and treatments of the disease.

Helping battle cancer is only one of many rewards we may reap from artificial intelligence in the future, as long as the benefits of those algorithms outweigh the costs of using them.

“Making AI more energy-efficient is an overarching objective that spans the fields of algorithms, systems, architecture, circuits, and devices,” Ielmini said.

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Posted in Human Robots

#436526 Not Bot, Not Beast: Scientists Create ...

A remarkable combination of artificial intelligence (AI) and biology has produced the world’s first “living robots.”

This week, a research team of roboticists and scientists published their recipe for making a new lifeform called xenobots from stem cells. The term “xeno” comes from the frog cells (Xenopus laevis) used to make them.

One of the researchers described the creation as “neither a traditional robot nor a known species of animal,” but a “new class of artifact: a living, programmable organism.”

Xenobots are less than 1 millimeter long and made of 500-1,000 living cells. They have various simple shapes, including some with squat “legs.” They can propel themselves in linear or circular directions, join together to act collectively, and move small objects. Using their own cellular energy, they can live up to 10 days.

While these “reconfigurable biomachines” could vastly improve human, animal, and environmental health, they raise legal and ethical concerns.

Strange New ‘Creature’
To make xenobots, the research team used a supercomputer to test thousands of random designs of simple living things that could perform certain tasks.

The computer was programmed with an AI “evolutionary algorithm” to predict which organisms would likely display useful tasks, such as moving towards a target.

After the selection of the most promising designs, the scientists attempted to replicate the virtual models with frog skin or heart cells, which were manually joined using microsurgery tools. The heart cells in these bespoke assemblies contract and relax, giving the organisms motion.

The creation of xenobots is groundbreaking. Despite being described as “programmable living robots,” they are actually completely organic and made of living tissue. The term “robot” has been used because xenobots can be configured into different forms and shapes, and “programmed” to target certain objects, which they then unwittingly seek. They can also repair themselves after being damaged.

Possible Applications
Xenobots may have great value. Some speculate they could be used to clean our polluted oceans by collecting microplastics. Similarly, they may be used to enter confined or dangerous areas to scavenge toxins or radioactive materials. Xenobots designed with carefully shaped “pouches” might be able to carry drugs into human bodies.

Future versions may be built from a patient’s own cells to repair tissue or target cancers. Being biodegradable, xenobots would have an edge on technologies made of plastic or metal.

Further development of biological “robots” could accelerate our understanding of living and robotic systems. Life is incredibly complex, so manipulating living things could reveal some of life’s mysteries—and improve our use of AI.

Legal and Ethical Questions
Conversely, xenobots raise legal and ethical concerns. In the same way they could help target cancers, they could also be used to hijack life functions for malevolent purposes.

Some argue artificially making living things is unnatural, hubristic, or involves “playing God.” A more compelling concern is that of unintended or malicious use, as we have seen with technologies in fields including nuclear physics, chemistry, biology and AI. For instance, xenobots might be used for hostile biological purposes prohibited under international law.

More advanced future xenobots, especially ones that live longer and reproduce, could potentially “malfunction” and go rogue, and out-compete other species.

For complex tasks, xenobots may need sensory and nervous systems, possibly resulting in their sentience. A sentient programmed organism would raise additional ethical questions. Last year, the revival of a disembodied pig brain elicited concerns about different species’ suffering.

Managing Risks
The xenobot’s creators have rightly acknowledged the need for discussion around the ethics of their creation. The 2018 scandal over using CRISPR (which allows the introduction of genes into an organism) may provide an instructive lesson here. While the experiment’s goal was to reduce the susceptibility of twin baby girls to HIV-AIDS, associated risks caused ethical dismay. The scientist in question is in prison.

When CRISPR became widely available, some experts called for a moratorium on heritable genome editing. Others argued the benefits outweighed the risks.

While each new technology should be considered impartially and based on its merits, giving life to xenobots raises certain significant questions:

Should xenobots have biological kill-switches in case they go rogue?
Who should decide who can access and control them?
What if “homemade” xenobots become possible? Should there be a moratorium until regulatory frameworks are established? How much regulation is required?

Lessons learned in the past from advances in other areas of science could help manage future risks, while reaping the possible benefits.

Long Road Here, Long Road Ahead
The creation of xenobots had various biological and robotic precedents. Genetic engineering has created genetically modified mice that become fluorescent in UV light.

Designer microbes can produce drugs and food ingredients that may eventually replace animal agriculture. In 2012, scientists created an artificial jellyfish called a “medusoid” from rat cells.

Robotics is also flourishing. Nanobots can monitor people’s blood sugar levels and may eventually be able to clear clogged arteries. Robots can incorporate living matter, which we witnessed when engineers and biologists created a sting-ray robot powered by light-activated cells.

In the coming years, we are sure to see more creations like xenobots that evoke both wonder and due concern. And when we do, it is important we remain both open-minded and critical.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Posted in Human Robots

#436491 The Year’s Most Fascinating Tech ...

Last Saturday we took a look at some of the most-read Singularity Hub articles from 2019. This week, we’re featuring some of our favorite articles from the last year. As opposed to short pieces about what’s happening, these are long reads about why it matters and what’s coming next. Some of them make the news while others frame the news, go deep on big ideas, go behind the scenes, or explore the human side of technological progress.

We hope you find them as fascinating, inspiring, and illuminating as we did.

DeepMind and Google: The Battle to Control Artificial Intelligence
Hal Hodson | 1843
“[DeepMind cofounder and CEO Demis] Hassabis thought DeepMind would be a hybrid: it would have the drive of a startup, the brains of the greatest universities, and the deep pockets of one of the world’s most valuable companies. Every element was in place to hasten the arrival of [artificial general intelligence] and solve the causes of human misery.”

The Most Powerful Person in Silicon Valley
Katrina Brooker | Fast Company
“Billionaire Masayoshi Son—not Elon Musk, Jeff Bezos, or Mark Zuckerberg—has the most audacious vision for an AI-powered utopia where machines control how we live. And he’s spending hundreds of billions of dollars to realize it. Are you ready to live in Masa World?”

AR Will Spark the Next Big Tech Platform—Call It Mirrorworld
Kevin Kelly | Wired
“Eventually this melded world will be the size of our planet. It will be humanity’s greatest achievement, creating new levels of wealth, new social problems, and uncountable opportunities for billions of people. There are no experts yet to make this world; you are not late.”

Behind the Scenes of a Radical New Cancer Cure
Ilana Yurkiewicz | Undark
“I remember the first time I watched a patient get his Day 0 infusion. It felt anti-climactic. The entire process took about 15 minutes. The CAR-T cells are invisible to the naked eye, housed in a small plastic bag containing clear liquid. ‘That’s it?’ my patient asked when the nurse said it was over. The infusion part is easy. The hard part is everything that comes next.”

The Promise and Price of Cellular Therapies
Siddhartha Mukherjee | The New Yorker
“We like to imagine medical revolutions as, well, revolutionary—propelled forward through leaps of genius and technological innovation. But they are also evolutionary, nudged forward through the optimization of design and manufacture.”

Impossible Foods’ Rising Empire of Almost Meat
Chris Ip | Engadget
“Impossible says it wants to ultimately create a parallel universe of ersatz animal products from steak to eggs. …Yet as Impossible ventures deeper into the culinary uncanny valley, it also needs society to discard a fundamental cultural idea that dates back millennia and accept a new truth: Meat doesn’t have to come from animals.”

Inside the Amazon Warehouse Where Humans and Machines Become One
Matt Simon | Wired
“Seen from above, the scale of the system is dizzying. My robot, a little orange slab known as a ‘drive’ (or more formally and mythically, Pegasus), is just one of hundreds of its kind swarming a 125,000-square-foot ‘field’ pockmarked with chutes. It’s a symphony of electric whirring, with robots pausing for one another at intersections and delivering their packages to the slides.”

Boston Dynamics’ Robots Are Preparing to Leave the Lab—Is the World Ready?
James Vincent | The Verge
“After decades of kicking machines in parking lots, the company is set to launch its first ever commercial bot later this year: the quadrupedal Spot. It’s a crucial test for a company that’s spent decades pursuing long-sighted R&D. And more importantly, the success—or failure—of Spot will tell us a lot about our own robot future. Are we ready for machines to walk among us?”

I Cut the ‘Big Five’ Tech Giants From My Life. It Was Hell
Kashmir Hill | Gizmodo
“Critics of the big tech companies are often told, ‘If you don’t like the company, don’t use its products.’ I did this experiment to find out if that is possible, and I found out that it’s not—with the exception of Apple. …These companies are unavoidable because they control internet infrastructure, online commerce, and information flows.”

Why I (Still) Love Tech: In Defense of a Difficult Industry
Paul Ford | Wired
“The mysteries of software caught my eye when I was a boy, and I still see it with the same wonder, even though I’m now an adult. Proudshamed, yes, but I still love it, the mess of it, the code and toolkits, down to the pixels and the processors, and up to the buses and bridges. I love the whole made world. But I can’t deny that the miracle is over, and that there is an unbelievable amount of work left for us to do.”

The Peculiar Blindness of Experts
David Epstein | The Atlantic
“In business, esteemed (and lavishly compensated) forecasters routinely are wildly wrong in their predictions of everything from the next stock-market correction to the next housing boom. Reliable insight into the future is possible, however. It just requires a style of thinking that’s uncommon among experts who are certain that their deep knowledge has granted them a special grasp of what is to come.”

The Most Controversial Tree in the World
Rowan Jacobson | Pacific Standard
“…we are all GMOs, the beneficiaries of freakishly unlikely genetic mash-ups, and the real Island of Dr. Moreau is that blue-green botanical garden positioned third from the sun. Rather than changing the nature of nature, as I once thought, this might just be the very nature of nature.”

How an Augmented Reality Game Escalated Into Real-World Spy Warfare
Elizabeth Ballou | Vice
“In Ingress, players accept that every park and train station could be the site of an epic showdown, but that’s only the first step. The magic happens when other people accept that, too. When players feel like that magic is real, there are few limits to what they’ll do or where they’ll go for the sake of the game. ”

The Shady Cryptocurrency Boom on the Post-Soviet Frontier
Hannah Lucinda Smith | Wired
“…although the tourists won’t guess it as they stand at Kuchurgan’s gates, admiring how the evening light reflects off the silver plaque of Lenin, this plant is pumping out juice to a modern-day gold rush: a cryptocurrency boom that is underway all across the former Soviet Union, from the battlefields of eastern Ukraine to time-warp enclaves like Transnistria and freshly annexed Crimea.”

Scientists Are Totally Rethinking Animal Cognition
Ross Andersen | The Atlantic
“This idea that animals are conscious was long unpopular in the West, but it has lately found favor among scientists who study animal cognition. …For many scientists, the resonant mystery is no longer which animals are conscious, but which are not.”

I Wrote This on a 30-Year-Old Computer
Ian Bogost | The Atlantic
“[Back then] computing was an accompaniment to life, rather than the sieve through which all ideas and activities must filter. That makes using this 30-year-old device a surprising joy, one worth longing for on behalf of what it was at the time, rather than for the future it inaugurated.”

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Posted in Human Robots

#436482 50+ Reasons Our Favorite Emerging ...

For most of history, technology was about atoms, the manipulation of physical stuff to extend humankind’s reach. But in the last five or six decades, atoms have partnered with bits, the elemental “particles” of the digital world as we know it today. As computing has advanced at the accelerating pace described by Moore’s Law, technological progress has become increasingly digitized.

SpaceX lands and reuses rockets and self-driving cars do away with drivers thanks to automation, sensors, and software. Businesses find and hire talent from anywhere in the world, and for better and worse, a notable fraction of the world learns and socializes online. From the sequencing of DNA to artificial intelligence and from 3D printing to robotics, more and more new technologies are moving at a digital pace and quickly emerging to reshape the world around us.

In 2019, stories charting the advances of some of these digital technologies consistently made headlines. Below is, what is at best, an incomplete list of some of the big stories that caught our eye this year. With so much happening, it’s likely we’ve missed some notable headlines and advances—as well as some of your personal favorites. In either instance, share your thoughts and candidates for the biggest stories and breakthroughs on Facebook and Twitter.

With that said, let’s dive straight into the year.

Artificial Intelligence
No technology garnered as much attention as AI in 2019. With good reason. Intelligent computer systems are transitioning from research labs to everyday life. Healthcare, weather forecasting, business process automation, traffic congestion—you name it, and machine learning algorithms are likely beginning to work on it. Yet, AI has also been hyped up and overmarketed, and the latest round of AI technology, deep learning, is likely only one piece of the AI puzzle.

This year, Open AI’s game-playing algorithms beat some of the world’s best Dota 2 players, DeepMind notched impressive wins in Starcraft, and Carnegie Mellon University’s Libratus “crushed” pros at six-player Texas Hold‘em.
Speaking of games, AI’s mastery of the incredibly complex game of Go prompted a former world champion to quit, stating that AI ‘”cannot be defeated.”
But it isn’t just fun and games. Practical, powerful applications that make the best of AI’s pattern recognition abilities are on the way. Insilico Medicine, for example, used machine learning to help discover and design a new drug in just 46 days, and DeepMind is focused on using AI to crack protein folding.
Of course, AI can be a double-edged sword. When it comes to deepfakes and fake news, for example, AI makes both easier to create and detect, and early in the year, OpenAI created and announced a powerful AI text generator but delayed releasing it for fear of malicious use.
Recognizing AI’s power for good and ill, the OECD, EU, World Economic Forum, and China all took a stab at defining an ethical framework for the development and deployment of AI.

Computing Systems
Processors and chips kickstarted the digital boom and are still the bedrock of continued growth. While progress in traditional silicon-based chips continues, it’s slowing and getting more expensive. Some say we’re reaching the end of Moore’s Law. While that may be the case for traditional chips, specialized chips and entirely new kinds of computing are waiting in the wings.

In fall 2019, Google confirmed its quantum computer had achieved “quantum supremacy,” a term that means a quantum computer can perform a calculation a normal computer cannot. IBM pushed back on the claim, and it should be noted the calculation was highly specialized. But while it’s still early days, there does appear to be some real progress (and more to come).
Should quantum computing become truly practical, “the implications are staggering.” It could impact machine learning, medicine, chemistry, and materials science, just to name a few areas.
Specialized chips continue to take aim at machine learning—a giant new chip with over a trillion transistors, for example, may make machine learning algorithms significantly more efficient.
Cellular computers also saw advances in 2019 thanks to CRISPR. And the year witnessed the emergence of the first reprogrammable DNA computer and new chips inspired by the brain.
The development of hardware computing platforms is intrinsically linked to software. 2019 saw a continued move from big technology companies towards open sourcing (at least parts of) their software, potentially democratizing the use of advanced systems.

Networks
Increasing interconnectedness has, in many ways, defined the 21st century so far. Your phone is no longer just a phone. It’s access to the world’s population and accumulated knowledge—and it fits in your pocket. Pretty neat. This is all thanks to networks, which had some notable advances in 2019.

The biggest network development of the year may well be the arrival of the first 5G networks.
5G’s faster speeds promise advances across many emerging technologies.
Self-driving vehicles, for example, may become both smarter and safer thanks to 5G C-V2X networks. (Don’t worry with trying to remember that. If they catch on, they’ll hopefully get a better name.)
Wi-Fi may have heard the news and said “hold my beer,” as 2019 saw the introduction of Wi-Fi 6. Perhaps the most important upgrade, among others, is that Wi-Fi 6 ensures that the ever-growing number of network connected devices get higher data rates.
Networks also went to space in 2019, as SpaceX began launching its Starlink constellation of broadband satellites. In typical fashion, Elon Musk showed off the network’s ability to bounce data around the world by sending a Tweet.

Augmented Reality and Virtual Reality
Forget Pokemon Go (unless you want to add me as a friend in the game—in which case don’t forget Pokemon Go). 2019 saw AR and VR advance, even as Magic Leap, the most hyped of the lot, struggled to live up to outsized expectations and sell headsets.

Mixed reality AR and VR technologies, along with the explosive growth of sensor-based data about the world around us, is creating a one-to-one “Mirror World” of our physical reality—a digital world you can overlay on our own or dive into immersively thanks to AR and VR.
Facebook launched Replica, for example, which is a photorealistic virtual twin of the real world that, among other things, will help train AIs to better navigate their physical surroundings.
Our other senses (beyond eyes) may also become part of the Mirror World through the use of peripherals like a newly developed synthetic skin that aim to bring a sense of touch to VR.
AR and VR equipment is also becoming cheaper—with more producers entering the space—and more user-friendly. Instead of a wired headset requiring an expensive gaming PC, the new Oculus Quest is a wireless, self-contained step toward the mainstream.
Niche uses also continue to gain traction, from Google Glass’s Enterprise edition to the growth of AR and VR in professional education—including on-the-job-training and roleplaying emotionally difficult work encounters, like firing an employee.

Digital Biology and Biotech
The digitization of biology is happening at an incredible rate. With wild new research coming to light every year and just about every tech giant pouring money into new solutions and startups, we’re likely to see amazing advances in 2020 added to those we saw in 2019.

None were, perhaps, more visible than the success of protein-rich, plant-based substitutes for various meats. This was the year Beyond Meat was the top IPO on the NASDAQ stock exchange and people stood in line for the plant-based Impossible Whopper and KFC’s Beyond Chicken.
In the healthcare space, a report about three people with HIV who became virus free thanks to a bone marrow transplants of stem cells caused a huge stir. The research is still in relatively early stages, and isn’t suitable for most people, but it does provides a glimmer of hope.
CRISPR technology, which almost deserves its own section, progressed by leaps and bounds. One tweak made CRISPR up to 50 times more accurate, while the latest new CRISPR-based system, CRISPR prime, was described as a “word processor” for gene editing.
Many areas of healthcare stand to gain from CRISPR. For instance, cancer treatment, were a first safety test showed ‘promising’ results.
CRISPR’s many potential uses, however, also include some weird/morally questionable areas, which was exemplified by one the year’s stranger CRISPR-related stories about a human-monkey hybrid embryo in China.
Incidentally, China could be poised to take the lead on CRISPR thanks to massive investments and research programs.
As a consequence of quick advances in gene editing, we are approaching a point where we will be able to design our own biology—but first we need to have a serious conversation as a society about the ethics of gene editing and what lines should be drawn.

3D Printing
3D printing has quietly been growing both market size and the objects the printers are capable of producing. While both are impressive, perhaps the biggest story of 2019 is their increased speed.

One example was a boat that was printed in just three days, which also set three new world records for 3D printing.
3D printing is also spreading in the construction industry. In Mexico, the technology is being used to construct 50 new homes with subsidized mortgages of just $20/month.
3D printers also took care of all parts of a 640 square-meter home in Dubai.
Generally speaking, the use of 3D printing to make parts for everything from rocket engines (even entire rockets) to trains to cars illustrates the sturdiness of the technology, anno 2019.
In healthcare, 3D printing is also advancing the cause of bio-printed organs and, in one example, was used to print vascularized parts of a human heart.

Robotics
Living in Japan, I get to see Pepper, Aibo, and other robots on pretty much a daily basis. The novelty of that experience is spreading to other countries, and robots are becoming a more visible addition to both our professional and private lives.

We can’t talk about robots and 2019 without mentioning Boston Dynamics’ Spot robot, which went on sale for the general public.
Meanwhile, Google, Boston Dynamics’ former owner, rebooted their robotics division with a more down-to-earth focus on everyday uses they hope to commercialize.
SoftBank’s Pepper robot is working as a concierge and receptionist in various countries. It is also being used as a home companion. Not satisfied, Pepper rounded off 2019 by heading to the gym—to coach runners.
Indeed, there’s a growing list of sports where robots perform as well—or better—than humans.
2019 also saw robots launch an assault on the kitchen, including the likes of Samsung’s robot chef, and invade the front yard, with iRobot’s Terra robotic lawnmower.
In the borderlands of robotics, full-body robotic exoskeletons got a bit more practical, as the (by all accounts) user-friendly, battery-powered Sarcos Robotics Guardian XO went commercial.

Autonomous Vehicles
Self-driving cars did not—if you will forgive the play on words—stay quite on track during 2019. The fallout from Uber’s 2018 fatal crash marred part of the year, while some big players ratcheted back expectations on a quick shift to the driverless future. Still, self-driving cars, trucks, and other autonomous systems did make progress this year.

Winner of my unofficial award for best name in self-driving goes to Optimus Ride. The company also illustrates that self-driving may not be about creating a one-size-fits-all solution but catering to specific markets.
Self-driving trucks had a good year, with tests across many countries and states. One of the year’s odder stories was a self-driving truck traversing the US with a delivery of butter.
A step above the competition may be the future slogan (or perhaps not) of Boeing’s self-piloted air taxi that saw its maiden test flight in 2019. It joins a growing list of companies looking to create autonomous, flying passenger vehicles.
2019 was also the year where companies seemed to go all in on last-mile autonomous vehicles. Who wins that particular competition could well emerge during 2020.

Blockchain and Digital Currencies
Bitcoin continues to be the cryptocurrency equivalent of a rollercoaster, but the underlying blockchain technology is progressing more steadily. Together, they may turn parts of our financial systems cashless and digital—though how and when remains a slightly open question.

One indication of this was Facebook’s hugely controversial announcement of Libra, its proposed cryptocurrency. The company faced immediate pushback and saw a host of partners jump ship. Still, it brought the tech into mainstream conversations as never before and is putting the pressure on governments and central banks to explore their own digital currencies.
Deloitte’s in-depth survey of the state of blockchain highlighted how the technology has moved from fintech into just about any industry you can think of.
One of the biggest issues facing the spread of many digital currencies—Bitcoin in particular, you could argue—is how much energy it consumes to mine them. 2019 saw the emergence of several new digital currencies with a much smaller energy footprint.
2019 was also a year where we saw a new kind of digital currency, stablecoins, rise to prominence. As the name indicates, stablecoins are a group of digital currencies whose price fluctuations are more stable than the likes of Bitcoin.
In a geopolitical sense, 2019 was a year of China playing catch-up. Having initially banned blockchain, the country turned 180 degrees and announced that it was “quite close” to releasing a digital currency and a wave of blockchain-programs.

Renewable Energy and Energy Storage
While not every government on the planet seems to be a fan of renewable energy, it keeps on outperforming fossil fuel after fossil fuel in places well suited to it—even without support from some of said governments.

One of the reasons for renewable energy’s continued growth is that energy efficiency levels keep on improving.
As a result, an increased number of coal plants are being forced to close due to an inability to compete, and the UK went coal-free for a record two weeks.
We are also seeing more and more financial institutions refusing to fund fossil fuel projects. One such example is the European Investment Bank.
Renewable energy’s advance is tied at the hip to the rise of energy storage, which also had a breakout 2019, in part thanks to investments from the likes of Bill Gates.
The size and capabilities of energy storage also grew in 2019. The best illustration came from Australia were Tesla’s mega-battery proved that energy storage has reached a stage where it can prop up entire energy grids.

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Posted in Human Robots

#436437 Why AI Will Be the Best Tool for ...

Dmitry Kaminskiy speaks as though he were trying to unload everything he knows about the science and economics of longevity—from senolytics research that seeks to stop aging cells from spewing inflammatory proteins and other molecules to the trillion-dollar life extension industry that he and his colleagues are trying to foster—in one sitting.

At the heart of the discussion with Singularity Hub is the idea that artificial intelligence will be the engine that drives breakthroughs in how we approach healthcare and healthy aging—a concept with little traction even just five years ago.

“At that time, it was considered too futuristic that artificial intelligence and data science … might be more accurate compared to any hypothesis of human doctors,” said Kaminskiy, co-founder and managing partner at Deep Knowledge Ventures, an investment firm that is betting big on AI and longevity.

How times have changed. Artificial intelligence in healthcare is attracting more investments and deals than just about any sector of the economy, according to data research firm CB Insights. In the most recent third quarter, AI healthcare startups raised nearly $1.6 billion, buoyed by a $550 million mega-round from London-based Babylon Health, which uses AI to collect data from patients, analyze the information, find comparable matches, then make recommendations.

Even without the big bump from Babylon Health, AI healthcare startups raised more than $1 billion last quarter, including two companies focused on longevity therapeutics: Juvenescence and Insilico Medicine.

The latter has risen to prominence for its novel use of reinforcement learning and general adversarial networks (GANs) to accelerate the drug discovery process. Insilico Medicine recently published a seminal paper that demonstrated how such an AI system could generate a drug candidate in just 46 days. Co-founder and CEO Alex Zhavoronkov said he believes there is no greater goal in healthcare today—or, really, any venture—than extending the healthy years of the human lifespan.

“I don’t think that there is anything more important than that,” he told Singularity Hub, explaining that an unhealthy society is detrimental to a healthy economy. “I think that it’s very, very important to extend healthy, productive lifespan just to fix the economy.”

An Aging Crisis
The surge of interest in longevity is coming at a time when life expectancy in the US is actually dropping, despite the fact that we spend more money on healthcare than any other nation.

A new paper in the Journal of the American Medical Association found that after six decades of gains, life expectancy for Americans has decreased since 2014, particularly among young and middle-aged adults. While some of the causes are societal, such as drug overdoses and suicide, others are health-related.

While average life expectancy in the US is 78, Kaminskiy noted that healthy life expectancy is about ten years less.

To Zhavoronkov’s point about the economy (a topic of great interest to Kaminskiy as well), the US spent $1.1 trillion on chronic diseases in 2016, according to a report from the Milken Institute, with diabetes, cardiovascular conditions, and Alzheimer’s among the most costly expenses to the healthcare system. When the indirect costs of lost economic productivity are included, the total price tag of chronic diseases in the US is $3.7 trillion, nearly 20 percent of GDP.

“So this is the major negative feedback on the national economy and creating a lot of negative social [and] financial issues,” Kaminskiy said.

Investing in Longevity
That has convinced Kaminskiy that an economy focused on extending healthy human lifespans—including the financial instruments and institutions required to support a long-lived population—is the best way forward.

He has co-authored a book on the topic with Margaretta Colangelo, another managing partner at Deep Knowledge Ventures, which has launched a specialized investment fund, Longevity.Capital, focused on the longevity industry. Kaminskiy estimates that there are now about 20 such investment funds dedicated to funding life extension companies.

In November at the inaugural AI for Longevity Summit in London, he and his collaborators also introduced the Longevity AI Consortium, an academic-industry initiative at King’s College London. Eventually, the research center will include an AI Longevity Accelerator program to serve as a bridge between startups and UK investors.

Deep Knowledge Ventures has committed about £7 million ($9 million) over the next three years to the accelerator program, as well as establishing similar consortiums in other regions of the world, according to Franco Cortese, a partner at Longevity.Capital and director of the Aging Analytics Agency, which has produced a series of reports on longevity.

A Cure for What Ages You
One of the most recent is an overview of Biomarkers for Longevity. A biomarker, in the case of longevity, is a measurable component of health that can indicate a disease state or a more general decline in health associated with aging. Examples range from something as simple as BMI as an indicator of obesity, which is associated with a number of chronic diseases, to sophisticated measurements of telomeres, the protective ends of chromosomes that shorten as we age.

While some researchers are working on moonshot therapies to reverse or slow aging—with a few even arguing we could expand human life on the order of centuries—Kaminskiy said he believes understanding biomarkers of aging could make more radical interventions unnecessary.

In this vision of healthcare, people would be able to monitor their health 24-7, with sensors attuned to various biomarkers that could indicate the onset of everything from the flu to diabetes. AI would be instrumental in not just ingesting the billions of data points required to develop such a system, but also what therapies, treatments, or micro-doses of a drug or supplement would be required to maintain homeostasis.

“Consider it like Tesla with many, many detectors, analyzing the behavior of the car in real time, and a cloud computing system monitoring those signals in real time with high frequency,” Kaminskiy explained. “So the same shall be applied for humans.”

And only sophisticated algorithms, Kaminskiy argued, can make longevity healthcare work on a mass scale but at the individual level. Precision medicine becomes preventive medicine. Healthcare truly becomes a system to support health rather than a way to fight disease.

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