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#439077 How Scientists Grew Human Muscles in Pig ...

The little pigs bouncing around the lab looked exceedingly normal. Yet their adorable exterior hid a remarkable secret: each piglet carried two different sets of genes. For now, both sets came from their own species. But one day, one of those sets may be human.

The piglets are chimeras—creatures with intermingled sets of genes, as if multiple entities were seamlessly mashed together. Named after the Greek lion-goat-serpent monsters, chimeras may hold the key to an endless supply of human organs and tissues for transplant. The crux is growing these human parts in another animal—one close enough in size and function to our own.

Last week, a team from the University of Minnesota unveiled two mind-bending chimeras. One was joyous little piglets, each propelled by muscles grown from a different pig. Another was pig embryos, transplanted into surrogate pigs, that developed human muscles for more than 20 days.

The study, led by Drs. Mary and Daniel Garry at the University of Minnesota, had a therapeutic point: engineering a brilliant way to replace muscle loss, especially for the muscles around our skeletons that allow us to move and navigate the world. Trauma and injury, such as from firearm wounds or car crashes, can damage muscle tissue beyond the point of repair. Unfortunately, muscles are also stubborn in that donor tissue from cadavers doesn’t usually “take” at the injury site. For now, there are no effective treatments for severe muscle death, called volumetric muscle loss.

The new human-pig hybrids are designed to tackle this problem. Muscle wasting aside, the study also points to a clever “hack” that increases the amount of human tissue inside a growing pig embryo.

If further improved, the technology could “provide an unlimited supply of organs for transplantation,” said Dr. Mary Garry to Inverse. What’s more, because the human tissue can be sourced from patients themselves, the risk of rejection by the immune system is relatively low—even when grown inside a pig.

“The shortage of organs for heart transplantation, vascular grafting, and skeletal muscle is staggering,” said Garry. Human-animal chimeras could have a “seismic impact” that transforms organ transplantation and helps solve the organ shortage crisis.

That is, if society accepts the idea of a semi-humanoid pig.

Wait…But How?
The new study took a page from previous chimera recipes.

The main ingredients and steps go like this: first, you need an embryo that lacks the ability to develop a tissue or organ. This leaves an “empty slot” of sorts that you can fill with another set of genes—pig, human, or even monkey.

Second, you need to fine-tune the recipe so that the embryos “take” the new genes, incorporating them into their bodies as if they were their own. Third, the new genes activate to instruct the growing embryo to make the necessary tissue or organs without harming the overall animal. Finally, the foreign genes need to stay put, without cells migrating to another body part—say, the brain.

Not exactly straightforward, eh? The piglets are technological wonders that mix cutting-edge gene editing with cloning technologies.

The team went for two chimeras: one with two sets of pig genes, the other with a pig and human mix. Both started with a pig embryo that can’t make its own skeletal muscles (those are the muscles surrounding your bones). Using CRISPR, the gene-editing Swiss Army Knife, they snipped out three genes that are absolutely necessary for those muscles to develop. Like hitting a bullseye with three arrows simultaneously, it’s already a technological feat.

Here’s the really clever part: the muscles around your bones have a slightly different genetic makeup than the ones that line your blood vessels or the ones that pump your heart. While the resulting pig embryos had severe muscle deformities as they developed, their hearts beat as normal. This means the gene editing cut only impacted skeletal muscles.

Then came step two: replacing the missing genes. Using a microneedle, the team injected a fertilized and slightly developed pig egg—called a blastomere—into the embryo. If left on its natural course, a blastomere eventually develops into another embryo. This step “smashes” the two sets of genes together, with the newcomer filling the muscle void. The hybrid embryo was then placed into a surrogate, and roughly four months later, chimeric piglets were born.

Equipped with foreign DNA, the little guys nevertheless seemed totally normal, nosing around the lab and running everywhere without obvious clumsy stumbles. Under the microscope, their “xenomorph” muscles were indistinguishable from run-of-the-mill average muscle tissue—no signs of damage or inflammation, and as stretchy and tough as muscles usually are. What’s more, the foreign DNA seemed to have only developed into muscles, even though they were prevalent across the body. Extensive fishing experiments found no trace of the injected set of genes inside blood vessels or the brain.

A Better Human-Pig Hybrid
Confident in their recipe, the team next repeated the experiment with human cells, with a twist. Instead of using controversial human embryonic stem cells, which are obtained from aborted fetuses, they relied on induced pluripotent stem cells (iPSCs). These are skin cells that have been reverted back into a stem cell state.

Unlike previous attempts at making human chimeras, the team then scoured the genetic landscape of how pig and human embryos develop to find any genetic “brakes” that could derail the process. One gene, TP53, stood out, which was then promptly eliminated with CRISPR.

This approach provides a way for future studies to similarly increase the efficiency of interspecies chimeras, the team said.

The human-pig embryos were then carefully grown inside surrogate pigs for less than a month, and extensively analyzed. By day 20, the hybrids had already grown detectable human skeletal muscle. Similar to the pig-pig chimeras, the team didn’t detect any signs that the human genes had sprouted cells that would eventually become neurons or other non-muscle cells.

For now, human-animal chimeras are not allowed to grow to term, in part to stem the theoretical possibility of engineering humanoid hybrid animals (shudder). However, a sentient human-pig chimera is something that the team specifically addressed. Through multiple experiments, they found no trace of human genes in the embryos’ brain stem cells 20 and 27 days into development. Similarly, human donor genes were absent in cells that would become the hybrid embryos’ reproductive cells.

Despite bioethical quandaries and legal restrictions, human-animal chimeras have taken off, both as a source of insight into human brain development and a well of personalized organs and tissues for transplant. In 2019, Japan lifted its ban on developing human brain cells inside animal embryos, as well as the term limit—to global controversy. There’s also the question of animal welfare, given that hybrid clones will essentially become involuntary organ donors.

As the debates rage on, scientists are nevertheless pushing the limits of human-animal chimeras, while treading as carefully as possible.

“Our data…support the feasibility of the generation of these interspecies chimeras, which will serve as a model for translational research or, one day, as a source for xenotransplantation,” the team said.

Image Credit: Christopher Carson on Unsplash Continue reading

Posted in Human Robots

#439032 To Learn To Deal With Uncertainty, This ...

AI is endowing robots, autonomous vehicles and countless of other forms of tech with new abilities and levels of self-sufficiency. Yet these models faithfully “make decisions” based on whatever data is fed into them, which could have dangerous consequences. For instance, if an autonomous car is driving down a highway and the sensor picks up a confusing signal (e.g., a paint smudge that is incorrectly interpreted as a lane marking), this could cause the car to swerve into another lane unnecessarily.

But in the ever-evolving world of AI, researchers are developing new ways to address challenges like this. One group of researchers has devised a new algorithm that allows the AI model to account for uncertain data, which they describe in a study published February 15 in IEEE Transactions on Neural Networks and Learning Systems.

“While we would like robots to work seamlessly in the real world, the real world is full of uncertainty,” says Michael Everett, a post-doctoral associate at MIT who helped develop the new approach. “It's important for a system to be aware of what it knows and what it is unsure about, which has been a major challenge for modern AI.”

His team focused on a type of AI called reinforcement learning (RL), whereby the model tries to learn the “value” of taking each action in a given scenario through trial-and-error. They developed a secondary algorithm, called Certified Adversarial Robustness for deep RL (CARRL), that can be built on top of an existing RL model.

“Our key innovation is that rather than blindly trusting the measurements, as is done today [by AI models], our algorithm CARRL thinks through all possible measurements that could have been made, and makes a decision that considers the worst-case outcome,” explains Everett.

In their study, the researchers tested CARRL across several different tasks, including collision avoidance simulations and Atari pong. For younger readers who may not be familiar with it, Atari pong is a classic computer game whereby an electronic paddle is used to direct a ping pong on the screen. In the test scenario, CARRL helped move the paddle slightly higher or lower to compensate for the possibility that the ball could approach at a slightly different point than what the input data indicated. All the while, CARRL would try to ensure that the ball would make contact with at least some part of paddle.

Gif: MIT Aerospace Controls Laboratory

In a perfect world, the information that an AI model is fed would be accurate all the time and AI model will perform well (left). But in some cases, the AI may be given inaccurate data, causing it to miss its targets (middle). The new algorithm CARRL helps AIs account for uncertainty in its data inputs, yielding a better performance when relying on poor data (right).

Across all test scenarios, the RL model was better at compensating for potential inaccurate or “noisy” data with CARRL, than without CARRL.

But the results also show that, like with humans, too much self-doubt and uncertainty can be unhelpful. In the collision avoidance scenario, for example, indulging in too much uncertainty caused the main moving object in the simulation to avoid both the obstacle and its goal. “There is definitely a limit to how ‘skeptical’ the algorithm can be without becoming overly conservative,” Everett says.

This research was funded by Ford Motor Company, but Everett notes that it could be applicable under many other commercial applications requiring safety-aware AI, including aerospace, healthcare, or manufacturing domains.

“This work is a step toward my vision of creating ‘certifiable learning machines’—systems that can discover how to explore and perform in the real world on their own, while still having safety and robustness guarantees,” says Everett. “We'd like to bring CARRL into robotic hardware while continuing to explore the theoretical challenges at the interface of robotics and AI.” Continue reading

Posted in Human Robots

#438606 Hyundai Motor Group Introduces Two New ...

Over the past few weeks, we’ve seen a couple of new robots from Hyundai Motor Group. This is a couple more robots than I think I’ve seen from Hyundai Motor Group, like, ever. We’re particularly interested in them right now mostly because Hyundai Motor Group are the new owners of Boston Dynamics, and so far, these robots represent one of the most explicit indications we’ve got about exactly what Hyundai Motor Group wants their robots to be doing.

We know it would be a mistake to read too much into these new announcements, but we can’t help reading something into them, right? So let’s take a look at what Hyundai Motor Group has been up to recently. This first robot is DAL-e, what HMG is calling an “Advanced Humanoid Robot.”

According to Hyundai, DAL-e is “designed to pioneer the future of automated customer services,” and is equipped with “state-of-the-art artificial intelligence technology for facial recognition as well as an automatic communication system based on a language-comprehension platform.” You’ll find it in car showrooms, but only in Seoul, for now.

We don’t normally write about robots like these because they tend not to represent much that’s especially new or interesting in terms of robotic technology, capabilities, or commercial potential. There’s certainly nothing wrong with DAL-e—it’s moderately cute and appears to be moderately functional. We’ve seen other platforms (like Pepper) take on similar roles, and our impression is that the long-term cost effectiveness of these greeter robots tends to be somewhat limited. And unless there’s some hidden functionality that we’re not aware of, this robot doesn’t really seem to be pushing the envelope, but we’d love to be wrong about that.

The other new robot, announced yesterday, is TIGER (Transforming Intelligent Ground Excursion Robot). It’s a bit more interesting, although you’ll have to skip ahead about 1:30 in the video to get to it.

We’ve talked about how adding wheels can make legged robots faster and more efficient, but I’m honestly not sure that it works all that well going the other way (adding legs to wheeled robots) because rather than adding a little complexity to get a multi-modal system that you can use much of the time, you’re instead adding a lot of complexity to get a multi-modal system that you’re going to use sometimes.

You could argue, as perhaps Hyundai would, that the multi-modal system is critical to get TIGER to do what they want it to do, which seems to be primarily remote delivery. They mention operating in urban areas as well, where TIGER could use its legs to climb stairs, but I think it would be beat by more traditional wheeled platforms, or even whegged platforms, that are almost as capable while being much simpler and cheaper. For remote delivery, though, legs might be a necessary feature.

That is, if you assume that using a ground-based system is really the best way to go.

The TIGER concept can be integrated with a drone to transport it from place to place, so why not just use the drone to make the remote delivery instead? I guess maybe if you’re dealing with a thick tree canopy, the drone could drop TIGER off in a clearing and the robot could drive to its destination, but now we’re talking about developing a very complex system for a very specific use case. Even though Hyundai has said that they’re going to attempt to commercialize TIGER over the next five years, I think it’ll be tricky for them to successfully do so.

The best part about these robots from Hyundai is that between the two of them, they suggest that the company is serious about developing commercial robots as well as willing to invest in something that seems a little crazy. And you know who else is both of those things? Boston Dynamics. To be clear, it’s almost certain that both of Hyundai’s robots were developed well before the company was even thinking about acquiring Boston Dynamics, so the real question is: Where do these two companies go from here? Continue reading

Posted in Human Robots

#438014 Meet Blueswarm, a Smart School of ...

Anyone who’s seen an undersea nature documentary has marveled at the complex choreography that schooling fish display, a darting, synchronized ballet with a cast of thousands.

Those instinctive movements have inspired researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and the Wyss Institute for Biologically Inspired Engineering. The results could improve the performance and dependability of not just underwater robots, but other vehicles that require decentralized locomotion and organization, such as self-driving cars and robotic space exploration.

The fish collective called Blueswarm was created by a team led by Radhika Nagpal, whose lab is a pioneer in self-organizing systems. The oddly adorable robots can sync their movements like biological fish, taking cues from their plastic-bodied neighbors with no external controls required. Nagpal told IEEE Spectrum that this marks a milestone, demonstrating complex 3D behaviors with implicit coordination in underwater robots.

“Insights from this research will help us develop future miniature underwater swarms that can perform environmental monitoring and search in visually-rich but fragile environments like coral reefs,” Nagpal said. “This research also paves a way to better understand fish schools, by synthetically recreating their behavior.”

The research is published in Science Robotics, with Florian Berlinger as first author. Berlinger said the “Bluedot” robots integrate a trio of blue LED lights, a lithium-polymer battery, a pair of cameras, a Raspberry Pi computer and four controllable fins within a 3D-printed hull. The fish-lens cameras detect LED’s of their fellow swimmers, and apply a custom algorithm to calculate distance, direction and heading.

Based on that simple production and detection of LED light, the team proved that Blueswarm could self-organize behaviors, including aggregation, dispersal and circle formation—basically, swimming in a clockwise synchronization. Researchers also simulated a successful search mission, an autonomous Finding Nemo. Using their dispersion algorithm, the robot school spread out until one could detect a red light in the tank. Its blue LEDs then flashed, triggering the aggregation algorithm to gather the school around it. Such a robot swarm might prove valuable in search-and-rescue missions at sea, covering miles of open water and reporting back to its mates.

“Each Bluebot implicitly reacts to its neighbors’ positions,” Berlinger said. The fish—RoboCod, perhaps?—also integrate a Wifi module to allow uploading new behaviors remotely. The lab’s previous efforts include a 1,000-strong army of “Kilobots,” and a robotic construction crew inspired by termites. Both projects operated in two-dimensional space. But a 3D environment like air or water posed a tougher challenge for sensing and movement.

In nature, Berlinger notes, there’s no scaly CEO to direct the school’s movements. Nor do fish communicate their intentions. Instead, so-called “implicit coordination” guides the school’s collective behavior, with individual members executing high-speed moves based on what they see their neighbors doing. That decentralized, autonomous organization has long fascinated scientists, including in robotics.

“In these situations, it really benefits you to have a highly autonomous robot swarm that is self-sufficient. By using implicit rules and 3D visual perception, we were able to create a system with a high degree of autonomy and flexibility underwater where things like GPS and WiFi are not accessible.”

Berlinger adds the research could one day translate to anything that requires decentralized robots, from self-driving cars and Amazon warehouse vehicles to exploration of faraway planets, where poor latency makes it impossible to transmit commands quickly. Today’s semi-autonomous cars face their own technical hurdles in reliably sensing and responding to their complex environments, including when foul weather obscures onboard sensors or road markers, or when they can’t fix position via GPS. An entire subset of autonomous-car research involves vehicle-to-vehicle (V2V) communications that could give cars a hive mind to guide individual or collective decisions— avoiding snarled traffic, driving safely in tight convoys, or taking group evasive action during a crash that’s beyond their sensory range.

“Once we have millions of cars on the road, there can’t be one computer orchestrating all the traffic, making decisions that work for all the cars,” Berlinger said.

The miniature robots could also work long hours in places that are inaccessible to humans and divers, or even large tethered robots. Nagpal said the synthetic swimmers could monitor and collect data on reefs or underwater infrastructure 24/7, and work into tiny places without disturbing fragile equipment or ecosystems.

“If we could be as good as fish in that environment, we could collect information and be non-invasive, in cluttered environments where everything is an obstacle,” Nagpal said. Continue reading

Posted in Human Robots

#437971 Video Friday: Teleport Yourself Into ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online]
RoboSoft 2021 – April 12-16, 2021 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.

Samsung announced some new prototype robots at CES this week. It's a fancy video, but my guess is that the actual autonomy here is minimal at best.

[ Samsung ]

Some very impressive reactive agility from Ghost Robotics' little quadruped.

[ Ghost Robotics ]

Toyota Research Institute (TRI) is researching how to bring together the instinctive reflexes of professional drivers and automated driving technology that uses the calculated foresight of a supercomputer. Using a Toyota GR Supra, TRI will learn from some of the most skilled drivers in the world to develop sophisticated vehicle control algorithms. The project’s goal is to design a new level of active safety technology for the Toyota Guardian™ approach of amplifying human driving abilities and helping keep people safe.

[ TRI ]

The end of this video features one of the most satisfying-sounding drone outtakes I've ever heard,

[ ASL ]

Reachy can now run the first humanoid VR teleoperation app available on the market. This app allows you to place yourself in the body of a humanoid robot, in VR, wherever you are in the world, to remotely operate it and carry out complex tasks. With this new functionality, Reachy is able to learn from the demonstration of the humans who control it, which makes application development even easier.

[ Pollen Robotics ]

Thanks Elsa!

Boston Dynamics has inspired some dancing robot videos recently, including this from Marco Tempest.

[ Marco Tempest ]

MOFLIN is an AI Pet created from a totally new concept. It possesses emotional capabilities that evolve like living animals. With its warm soft fur, cute sounds, and adorable movement, you’d want to love it forever. We took a nature inspired approach and developed a unique algorithm that allows MOFLIN to learn and grow by constantly using its interactions to determine patterns and evaluate its surroundings from its sensors. MOFLIN will choose from an infinite number of mobile and sound pattern combinations to respond and express its feelings. To put it in simple terms, it’s like you’re interacting with a living pet.

I like the minimalist approach. I dislike the “it’s like you’re interacting with a living pet” bit.

[ Kickstarter ]

There's a short gif of these warehouse robots going around, but here's the full video.

[ BionicHIVE ]

Vstone's Robovie-Z proves that you don't need fancy hardware for effective teleworking.

[ Vstone ]

All dual-arm robots are required, at some point, to play pool.

[ ABB ]

Volkswagen Group Components gives us a first glimpse of the real prototypes. This is one of the visionary charging concepts that Volkswagen hopes will expand the charging infrastructure over the next few years. Its task: fully autonomous charging of vehicles in restricted parking areas, like underground car parks.

To charge several vehicles at the same time, the mobile robot moves a trailer, essentially a mobile energy storage unit, to the vehicle, connects it up and then uses this energy storage unit to charge the battery of the electric vehicle. The energy storage unit stays with the vehicle during the charging process. In the meantime, the robot charges other electric vehicles.

[ Volkswagen ]

I've got a lot of questions about Moley Robotics' kitchen. But I would immediately point out that the system appears to do no prep work, which (at least for me) is the time-consuming and stressful part of cooking.

[ Moley Robotics ]

Blueswarm is a collective of fish-inspired miniature underwater robots that can achieve a wide variety of 3D collective behaviors – synchrony, aggregation/dispersion, milling, search – using only implicit communication mediated through the production and sensing of blue light. We envision this platform for investigating collective AI, underwater coordination, and fish-inspired locomotion and sensing.

[ Science Robotics ]

A team of Malaysian researchers are transforming pineapple leaves into strong materials that can be used to build frames for unmanned aircraft or drones.

[ Reuters ]

The future of facility disinfecting is here, protect your customers, and create peace of mind. Our drone sanitization spraying technology is up to 100% more efficient and effective than conventional manual spray sterilization processes.

[ Draganfly ]

Robots are no long a future technology, as small robots can be purchased today to be utilized for educational purposes. See what goes into making a modern robot come to life.

[ Huggbees ]

How does a robot dog learn how to dance? Adam and the Tested team examine and dive into Boston Dynamics' Choreographer software that was behind Spot's recent viral dancing video.

[ Tested ]

For years, engineers have had to deal with “the tyranny of the fairing,” that anything you want to send into space has to fit into the protective nosecone on top of the rocket. A field of advanced design has been looking for new ways to improve our engineering, using the centuries-old artform to dream bigger.

[ JPL ] Continue reading

Posted in Human Robots