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#437701 Robotics, AI, and Cloud Computing ...

IBM must be brimming with confidence about its new automated system for performing chemical synthesis because Big Blue just had twenty or so journalists demo the complex technology live in a virtual room.

IBM even had one of the journalists choose the molecule for the demo: a molecule in a potential Covid-19 treatment. And then we watched as the system synthesized and tested the molecule and provided its analysis in a PDF document that we all saw in the other journalist’s computer. It all worked; again, that’s confidence.

The complex system is based upon technology IBM started developing three years ago that uses artificial intelligence (AI) to predict chemical reactions. In August 2018, IBM made this service available via the Cloud and dubbed it RXN for Chemistry.

Now, the company has added a new wrinkle to its Cloud-based AI: robotics. This new and improved system is no longer named simply RXN for Chemistry, but RoboRXN for Chemistry.

All of the journalists assembled for this live demo of RoboRXN could watch as the robotic system executed various steps, such as moving the reactor to a small reagent and then moving the solvent to a small reagent. The robotic system carried out the entire set of procedures—completing the synthesis and analysis of the molecule—in eight steps.

Image: IBM Research

IBM RXN helps predict chemical reaction outcomes or design retrosynthesis in seconds.

In regular practice, a user will be able to suggest a combination of molecules they would like to test. The AI will pick up the order and task a robotic system to run the reactions necessary to produce and test the molecule. Users will be provided analyses of how well their molecules performed.

Back in March of this year, Silicon Valley-based startup Strateos demonstrated something similar that they had developed. That system also employed a robotic system to help researchers working from the Cloud create new chemical compounds. However, what distinguishes IBM’s system is its incorporation of a third element: the AI.

The backbone of IBM’s AI model is a machine learning translation method that treats chemistry like language translation. It translates the language of chemistry by converting reactants and reagents to products through the use of Statistical Machine Intelligence and Learning Engine (SMILE) representation to describe chemical entities.

IBM has also leveraged an automatic data driven strategy to ensure the quality of its data. Researchers there used millions of chemical reactions to teach the AI system chemistry, but contained within that data set were errors. So, how did IBM clean this so-called noisy data to eliminate the potential for bad models?

According to Alessandra Toniato, a researcher at IBM Zurichh, the team implemented what they dubbed the “forgetting experiment.”

Toniato explains that, in this approach, they asked the AI model how sure it was that the chemical examples it was given were examples of correct chemistry. When faced with this choice, the AI identified chemistry that it had “never learnt,” “forgotten six times,” or “never forgotten.” Those that were “never forgotten” were examples that were clean, and in this way they were able to clean the data that AI had been presented.

While the AI has always been part of the RXN for Chemistry, the robotics is the newest element. The main benefit that turning over the carrying out of the reactions to a robotic system is expected to yield is to free up chemists from doing the often tedious process of having to design a synthesis from scratch, says Matteo Manica, a research staff member in Cognitive Health Care and Life Sciences at IBM Research Zürich.

“In this demo, you could see how the system is synergistic between a human and AI,” said Manica. “Combine that with the fact that we can run all these processes with a robotic system 24/7 from anywhere in the world, and you can see how it will really help up to speed up the whole process.”

There appear to be two business models that IBM is pursuing with its latest technology. One is to deploy the entire system on the premises of a company. The other is to offer licenses to private Cloud installations.

Photo: Michael Buholzer

Teodoro Laino of IBM Research Europe.

“From a business perspective you can think of having a system like we demonstrated being replicated on the premise within companies or research groups that would like to have the technology available at their disposal,” says Teodoro Laino, distinguished RSM, manager at IBM Research Europe. “On the other hand, we are also pushing at bringing the entire system to a service level.”

Just as IBM is brimming with confidence about its new technology, the company also has grand aspirations for it.

Laino adds: “Our aim is to provide chemical services across the world, a sort of Amazon of chemistry, where instead of looking for chemistry already in stock, you are asking for chemistry on demand.”

< Back to IEEE COVID-19 Resources Continue reading

Posted in Human Robots

#437683 iRobot Remembers That Robots Are ...

iRobot has released several new robots over the last few years, including the i7 and s9 vacuums. Both of these models are very fancy and very capable, packed with innovative and useful features that we’ve been impressed by. They’re both also quite expensive—with dirt docks included, you’re looking at US $800 for the i7+, and a whopping $1,100 for the s9+. You can knock a couple hundred bucks off of those prices if you don’t want the docks, but still, these vacuums are absolutely luxury items.

If you just want something that’ll do some vacuuming so that you don’t have to, iRobot has recently announced a new Roomba option. The Roomba i3 is iRobot’s new low to midrange vacuum, starting at $400. It’s not nearly as smart as the i7 or the s9, but it can navigate (sort of) and make maps (sort of) and do some basic smart home integration. If that sounds like all you need, the i3 could be the robot vacuum for you.

iRobot calls the i3 “stylish,” and it does look pretty neat with that fabric top. Underneath, you get dual rubber primary brushes plus a side brush. There’s limited compatibility with the iRobot Home app and IFTTT, along with Alexa and Google Home. The i3 is also compatible with iRobot’s Clean Base, but that’ll cost you an extra $200, and iRobot refers to this bundle as the i3+.

The reason that the i3 only offers limited compatibility with iRobot’s app is that the i3 is missing the top-mounted camera that you’ll find in more expensive models. Instead, it relies on a downward-looking optical sensor to help it navigate, and it builds up a map as it’s cleaning by keeping track of when it bumps into obstacles and paying attention to internal sensors like a gyro and wheel odometers. The i3 can localize directly on its charging station or Clean Base (which have beacons on them that the robot can see if it’s close enough), which allows it to resume cleaning after emptying it’s bin or recharging. You’ll get a map of the area that the i3 has cleaned once it’s finished, but that map won’t persist between cleaning sessions, meaning that you can’t do things like set keep-out zones or identify specific rooms for the robot to clean. Many of the more useful features that iRobot’s app offers are based on persistent maps, and this is probably the biggest gap in functionality between the i3 and its more expensive siblings.

According to iRobot senior global product manager Sarah Wang, the kind of augmented dead-reckoning-based mapping that the i3 uses actually works really well: “Based on our internal and external testing, the performance is equivalent with our products that have cameras, like the Roomba 960,” she says. To get this level of performance, though, you do have to be careful, Wang adds. “If you kidnap i3, then it will be very confused, because it doesn’t have a reference to know where it is.” “Kidnapping” is a term that’s used often in robotics to refer to a situation in which an autonomous robot gets moved to an unmapped location, and in the context of a home robot, the best example of this is if you decide that you want your robot to vacuum a different room instead, so you pick it up and move it there.

iRobot used to make this easy by giving all of its robots carrying handles, but not anymore, because getting moved around makes things really difficult for any robot trying to keep track of where it is. While robots like the i7 can recover using their cameras to look for unique features that they recognize, the only permanent, unique landmark that the i3 can for sure identify is the beacon on its dock. What this means is that when it comes to the i3, even more than other Roomba models, the best strategy, is to just “let it do its thing,” says iRobot senior principal system engineer Landon Unninayar.

Photo: iRobot

The Roomba i3 is iRobot’s new low to midrange vacuum, starting at $400.

If you’re looking to spend a bit less than the $400 starting price of the i3, there are other options to be aware of as well. The Roomba 614, for example, does a totally decent job and costs $250. It’s scheduling isn’t very clever, it doesn’t make maps, and it won’t empty itself, but it will absolutely help keep your floors clean as long as you don’t mind being a little bit more hands-on. (And there’s also Neato’s D4, which offers basic persistent maps—and lasers!—for $330.)

The other thing to consider if you’re trying to decide between the i3 and a more expensive Roomba is that without the camera, the i3 likely won’t be able to take advantage of nearly as many of the future improvements that iRobot has said it’s working on. Spending more money on a robot with additional sensors isn’t just buying what it can do now, but also investing in what it may be able to do later on, with its more sophisticated localization and ability to recognize objects. iRobot has promised major app updates every six months, and our guess is that most of the cool new stuff is going to show in the i7 and s9. So, if your top priority is just cleaner floors, the i3 is a solid choice. But if you want a part of what iRobot is working on next, the i3 might end up holding you back. Continue reading

Posted in Human Robots

#437673 Can AI and Automation Deliver a COVID-19 ...

Illustration: Marysia Machulska

Within moments of meeting each other at a conference last year, Nathan Collins and Yann Gaston-Mathé began devising a plan to work together. Gaston-Mathé runs a startup that applies automated software to the design of new drug candidates. Collins leads a team that uses an automated chemistry platform to synthesize new drug candidates.

“There was an obvious synergy between their technology and ours,” recalls Gaston-Mathé, CEO and cofounder of Paris-based Iktos.

In late 2019, the pair launched a project to create a brand-new antiviral drug that would block a specific protein exploited by influenza viruses. Then the COVID-19 pandemic erupted across the world stage, and Gaston-Mathé and Collins learned that the viral culprit, SARS-CoV-2, relied on a protein that was 97 percent similar to their influenza protein. The partners pivoted.

Their companies are just two of hundreds of biotech firms eager to overhaul the drug-discovery process, often with the aid of artificial intelligence (AI) tools. The first set of antiviral drugs to treat COVID-19 will likely come from sifting through existing drugs. Remdesivir, for example, was originally developed to treat Ebola, and it has been shown to speed the recovery of hospitalized COVID-19 patients. But a drug made for one condition often has side effects and limited potency when applied to another. If researchers can produce an ­antiviral that specifically targets SARS-CoV-2, the drug would likely be safer and more effective than a repurposed drug.

There’s one big problem: Traditional drug discovery is far too slow to react to a pandemic. Designing a drug from scratch typically takes three to five years—and that’s before human clinical trials. “Our goal, with the combination of AI and automation, is to reduce that down to six months or less,” says Collins, who is chief strategy officer at SRI Biosciences, a division of the Silicon Valley research nonprofit SRI International. “We want to get this to be very, very fast.”

That sentiment is shared by small biotech firms and big pharmaceutical companies alike, many of which are now ramping up automated technologies backed by supercomputing power to predict, design, and test new antivirals—for this pandemic as well as the next—with unprecedented speed and scope.

“The entire industry is embracing these tools,” says Kara Carter, president of the International Society for Antiviral Research and executive vice president of infectious disease at Evotec, a drug-discovery company in Hamburg. “Not only do we need [new antivirals] to treat the SARS-CoV-2 infection in the population, which is probably here to stay, but we’ll also need them to treat future agents that arrive.”

There are currentlyabout 200 known viruses that infect humans. Although viruses represent less than 14 percent of all known human pathogens, they make up two-thirds of all new human pathogens discovered since 1980.

Antiviral drugs are fundamentally different from vaccines, which teach a person’s immune system to mount a defense against a viral invader, and antibody treatments, which enhance the body’s immune response. By contrast, anti­virals are chemical compounds that directly block a virus after a person has become infected. They do this by binding to specific proteins and preventing them from functioning, so that the virus cannot copy itself or enter or exit a cell.

The SARS-CoV-2 virus has an estimated 25 to 29 proteins, but not all of them are suitable drug targets. Researchers are investigating, among other targets, the virus’s exterior spike protein, which binds to a receptor on a human cell; two scissorlike enzymes, called proteases, that cut up long strings of viral proteins into functional pieces inside the cell; and a polymerase complex that makes the cell churn out copies of the virus’s genetic material, in the form of single-stranded RNA.

But it’s not enough for a drug candidate to simply attach to a target protein. Chemists also consider how tightly the compound binds to its target, whether it binds to other things as well, how quickly it metabolizes in the body, and so on. A drug candidate may have 10 to 20 such objectives. “Very often those objectives can appear to be anticorrelated or contradictory with each other,” says Gaston-Mathé.

Compared with antibiotics, antiviral drug discovery has proceeded at a snail’s pace. Scientists advanced from isolating the first antibacterial molecules in 1910 to developing an arsenal of powerful antibiotics by 1944. By contrast, it took until 1951 for researchers to be able to routinely grow large amounts of virus particles in cells in a dish, a breakthrough that earned the inventors a Nobel Prize in Medicine in 1954.

And the lag between the discovery of a virus and the creation of a treatment can be heartbreaking. According to the World Health Organization, 71 million people worldwide have chronic hepatitis C, a major cause of liver cancer. The virus that causes the infection was discovered in 1989, but effective antiviral drugs didn’t hit the market until 2014.

While many antibiotics work on a range of microbes, most antivirals are highly specific to a single virus—what those in the business call “one bug, one drug.” It takes a detailed understanding of a virus to develop an antiviral against it, says Che Colpitts, a virologist at Queen’s University, in Canada, who works on antivirals against RNA viruses. “When a new virus emerges, like SARS-CoV-2, we’re at a big disadvantage.”

Making drugs to stop viruses is hard for three main reasons. First, viruses are the Spartans of the pathogen world: They’re frugal, brutal, and expert at evading the human immune system. About 20 to 250 nanometers in diameter, viruses rely on just a few parts to operate, hijacking host cells to reproduce and often destroying those cells upon departure. They employ tricks to camouflage their presence from the host’s immune system, including preventing infected cells from sending out molecular distress beacons. “Viruses are really small, so they only have a few components, so there’s not that many drug targets available to start with,” says Colpitts.

Second, viruses replicate quickly, typically doubling in number in hours or days. This constant copying of their genetic material enables viruses to evolve quickly, producing mutations able to sidestep drug effects. The virus that causes AIDS soon develops resistance when exposed to a single drug. That’s why a cocktail of antiviral drugs is used to treat HIV infection.

Finally, unlike bacteria, which can exist independently outside human cells, viruses invade human cells to propagate, so any drug designed to eliminate a virus needs to spare the host cell. A drug that fails to distinguish between a virus and a cell can cause serious side effects. “Discriminating between the two is really quite difficult,” says Evotec’s Carter, who has worked in antiviral drug discovery for over three decades.

And then there’s the money barrier. Developing antivirals is rarely profitable. Health-policy researchers at the London School of Economics recently estimated that the average cost of developing a new drug is US $1 billion, and up to $2.8 billion for cancer and other specialty drugs. Because antivirals are usually taken for only short periods of time or during short outbreaks of disease, companies rarely recoup what they spent developing the drug, much less turn a profit, says Carter.

To change the status quo, drug discovery needs fresh approaches that leverage new technologies, rather than incremental improvements, says Christian Tidona, managing director of BioMed X, an independent research institute in Heidelberg, Germany. “We need breakthroughs.”

Putting Drug Development on Autopilot
Earlier this year, SRI Biosciences and Iktos began collaborating on a way to use artificial intelligence and automated chemistry to rapidly identify new drugs to target the COVID-19 virus. Within four months, they had designed and synthesized a first round of antiviral candidates. Here’s how they’re doing it.

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STEP 1: Iktos’s AI platform uses deep-learning algorithms in an iterative process to come up with new molecular structures likely to bind to and disable a specific coronavirus protein. Illustrations: Chris Philpot

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STEP 2: SRI Biosciences’s SynFini system is a three-part automated chemistry suite for producing new compounds. Starting with a target compound from Iktos, SynRoute uses machine learning to analyze and optimize routes for creating that compound, with results in about 10 seconds. It prioritizes routes based on cost, likelihood of success, and ease of implementation.

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STEP 3: SynJet, an automated inkjet printer platform, tests the routes by printing out tiny quantities of chemical ingredients to see how they react. If the right compound is produced, the platform tests it.

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STEP 4: AutoSyn, an automated tabletop chemical plant, synthesizes milligrams to grams of the desired compound for further testing. Computer-selected “maps” dictate paths through the plant’s modular components.

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STEP 5: The most promising compounds are tested against live virus samples.

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Iktos’s AI platform was created by a medicinal chemist and an AI expert. To tackle SARS-CoV-2, the company used generative models—deep-learning algorithms that generate new data—to “imagine” molecular structures with a good chance of disabling a key coronavirus protein.

For a new drug target, the software proposes and evaluates roughly 1 million compounds, says Gaston-Mathé. It’s an iterative process: At each step, the system generates 100 virtual compounds, which are tested in silico with predictive models to see how closely they meet the objectives. The test results are then used to design the next batch of compounds. “It’s like we have a very, very fast chemist who is designing compounds, testing compounds, getting back the data, then designing another batch of compounds,” he says.

The computer isn’t as smart as a human chemist, Gaston-Mathé notes, but it’s much faster, so it can explore far more of what people in the field call “chemical space”—the set of all possible organic compounds. Unexplored chemical space is huge: Biochemists estimate that there are at least 1063 possible druglike molecules, and that 99.9 percent of all possible small molecules or compounds have never been synthesized.

Still, designing a chemical compound isn’t the hardest part of creating a new drug. After a drug candidate is designed, it must be synthesized, and the highly manual process for synthesizing a new chemical hasn’t changed much in 200 years. It can take days to plan a synthesis process and then months to years to optimize it for manufacture.

That’s why Gaston-Mathé was eager to send Iktos’s AI-generated designs to Collins’s team at SRI Biosciences. With $13.8 million from the Defense Advanced Research Projects Agency, SRI Biosciences spent the last four years automating the synthesis process. The company’s automated suite of three technologies, called SynFini, can produce new chemical compounds in just hours or days, says Collins.

First, machine-learning software devises possible routes for making a desired molecule. Next, an inkjet printer platform tests the routes by printing out and mixing tiny quantities of chemical ingredients to see how they react with one another; if the right compound is produced, the platform runs tests on it. Finally, a tabletop chemical plant synthesizes milligrams to grams of the desired compound.

Less than four months after Iktos and SRI Biosciences announced their collaboration, they had designed and synthesized a first round of antiviral candidates for SARS-CoV-2. Now they’re testing how well the compounds work on actual samples of the virus.

Out of 10
63 possible druglike molecules, 99.9 percent have never been synthesized.

Theirs isn’t the only collaborationapplying new tools to drug discovery. In late March, Alex Zhavoronkov, CEO of Hong Kong–based Insilico Medicine, came across a YouTube video showing three virtual-reality avatars positioning colorful, sticklike fragments in the side of a bulbous blue protein. The three researchers were using VR to explore how compounds might bind to a SARS-CoV-2 enzyme. Zhavoronkov contacted the startup that created the simulation—Nanome, in San Diego—and invited it to examine Insilico’s ­AI-generated molecules in virtual reality.

Insilico runs an AI platform that uses biological data to train deep-learning algorithms, then uses those algorithms to identify molecules with druglike features that will likely bind to a protein target. A four-day training sprint in late January yielded 100 molecules that appear to bind to an important SARS-CoV-2 protease. The company recently began synthesizing some of those molecules for laboratory testing.

Nanome’s VR software, meanwhile, allows researchers to import a molecular structure, then view and manipulate it on the scale of individual atoms. Like human chess players who use computer programs to explore potential moves, chemists can use VR to predict how to make molecules more druglike, says Nanome CEO Steve McCloskey. “The tighter the interface between the human and the computer, the more information goes both ways,” he says.

Zhavoronkov sent data about several of Insilico’s compounds to Nanome, which re-created them in VR. Nanome’s chemist demonstrated chemical tweaks to potentially improve each compound. “It was a very good experience,” says Zhavoronkov.

Meanwhile, in March, Takeda Pharmaceutical Co., of Japan, invited Schrödinger, a New York–based company that develops chemical-simulation software, to join an alliance working on antivirals. Schrödinger’s AI focuses on the physics of how proteins interact with small molecules and one another.

The software sifts through billions of molecules per week to predict a compound’s properties, and it optimizes for multiple desired properties simultaneously, says Karen Akinsanya, chief biomedical scientist and head of discovery R&D at Schrödinger. “There’s a huge sense of urgency here to come up with a potent molecule, but also to come up with molecules that are going to be well tolerated” by the body, she says. Drug developers are seeking compounds that can be broadly used and easily administered, such as an oral drug rather than an intravenous drug, she adds.

Schrödinger evaluated four protein targets and performed virtual screens for two of them, a computing-intensive process. In June, Google Cloud donated the equivalent of 16 million hours of Nvidia GPU time for the company’s calculations. Next, the alliance’s drug companies will synthesize and test the most promising compounds identified by the virtual screens.

Other companies, including Amazon Web Services, IBM, and Intel, as well as several U.S. national labs are also donating time and resources to the Covid-19 High Performance Computing Consortium. The consortium is supporting 87 projects, which now have access to 6.8 million CPU cores, 50,000 GPUs, and 600 petaflops of computational resources.

While advanced technologies could transform early drug discovery, any new drug candidate still has a long road after that. It must be tested in animals, manufactured in large batches for clinical trials, then tested in a series of trials that, for antivirals, lasts an average of seven years.

In May, the BioMed X Institute in Germany launched a five-year project to build a Rapid Antiviral Response Platform, which would speed drug discovery all the way through manufacturing for clinical trials. The €40 million ($47 million) project, backed by drug companies, will identify ­outside-the-box proposals from young scientists, then provide space and funding to develop their ideas.

“We’ll focus on technologies that allow us to go from identification of a new virus to 10,000 doses of a novel potential therapeutic ready for trials in less than six months,” says BioMed X’s Tidona, who leads the project.

While a vaccine will likely arrive long before a bespoke antiviral does, experts expect COVID-19 to be with us for a long time, so the effort to develop a direct-acting, potent antiviral continues. Plus, having new antivirals—and tools to rapidly create more—can only help us prepare for the next pandemic, whether it comes next month or in another 102 years.

“We’ve got to start thinking differently about how to be more responsive to these kinds of threats,” says Collins. “It’s pushing us out of our comfort zones.”

This article appears in the October 2020 print issue as “Automating Antivirals.” Continue reading

Posted in Human Robots

#437639 Boston Dynamics’ Spot Is Helping ...

In terms of places where you absolutely want a robot to go instead of you, what remains of the utterly destroyed Chernobyl Reactor 4 should be very near the top of your list. The reactor, which suffered a catastrophic meltdown in 1986, has been covered up in almost every way possible in an effort to keep its nuclear core contained. But eventually, that nuclear material is going to have to be dealt with somehow, and in order to do that, it’s important to understand which bits of it are just really bad, and which bits are the actual worst. And this is where Spot is stepping in to help.

The big open space that Spot is walking through is right next to what’s left of Reactor 4. Within six months of the disaster, Reactor 4 was covered in a sarcophagus made of concrete and steel to try and keep all the nasty nuclear fuel from leaking out more than it already had, and it still contains “30 tons of highly contaminated dust, 16 tons of uranium and plutonium, and 200 tons of radioactive lava.” Oof. Over the next 10 years, the sarcophagus slowly deteriorated, and despite the addition of that gigantic network of steel support beams that you can see in the video, in the late 1990s it was decided to erect an enormous building over the entire mess to try and stabilize it for as long as possible.

Reactor 4 is now snugly inside the massive New Safe Confinement (NSC) structure, and the idea is that eventually, the structure will allow for the safe disassembly of what’s left of the reactor, although nobody is quite sure how to do that. This is all just to say that the area inside of the containment structure offers a lot of good opportunities for robots to take over from humans.

This particular Spot is owned by the U.K. Atomic Energy Authority, and was packed off to Russia with the assistance of the Robotics and Artificial Intelligence in Nuclear (RAIN) initiative and the National Centre for Nuclear Robotics. Dr. Dave Megson-Smith, who is a researcher at the University of Bristol, in the U.K., and part of the Hot Robotics Facility at the National Nuclear User Facility, was one of the scientists lucky enough to accompany Spot on its adventure. Megson-Smith specializes in sensor development, and he equipped Spot with a collimated radiation sensor in addition to its mapping payload. “We actually built a map of the radiation coming out of the front wall of Chernobyl power plant as we were in there with it,” Megson-Smith told us, and was able to share this picture, which shows a map of gamma photon count rate:

Image: University of Bristol

Researchers equipped Spot with a collimated radiation sensor and use one of the data readings (gamma photon count rate) to create a map of the radiation coming out of the front wall of the Chernobyl power plant.

So what’s the reason you’d want to use a very expensive legged robot to wander around what looks like a very flat and robot friendly floor? As it turns out, the floor is very dusty in there, and a priority inside the NSC is to keep dust down as much as possible, since the dust is radioactive and gets on everything and is consequently the easiest way for radioactivity to escape the NSC. “You want to minimize picking up material, so we consider the total contact surface area,” says Megson-Smith. “If you use a legged system rather than a wheeled or tracked system, you have a much smaller footprint and you disturb the environment a lot less.” While it’s nice that Spot is nimble and can climb stairs and stuff, tracked vehicles can do that as well, so in this case, the primary driving factor of choosing a robot to work inside Chernobyl is minimizing those contact points.

Right now, routine weekly measurements in contaminated spaces at Chernobyl are done by humans, which puts those humans at risk. Spot, or a robot like it, could potentially take over from those humans, as a sort of “automated safety checker”

Right now, routine weekly measurements in contaminated spaces at Chernobyl are done by humans, which puts those humans at risk. Spot, or a robot like it, could potentially take over from those humans, as a sort of “automated safety checker” able to work in medium level contaminated environments.” As far as more dangerous areas go, there’s a lot of uncertainty about what Spot is actually capable of, according to Megson-Smith. “What you think the problems are, and what the industry thinks the problems are, are subtly different things.

We were thinking that we’d have to make robots incredibly radiation proof to go into these contaminated environments, but they said, “can you just give us a system that we can send into places where humans already can go, but where we just don’t want to send humans.” Making robots incredibly radiation proof is challenging, and without extensive testing and ruggedizing, failures can be frequent, as many robots discovered at Fukushima. Indeed, Megson-Smith that in Fukushima there’s a particular section that’s known as a “robot graveyard” where robots just go to die, and they’ve had to up their standards again and again to keep the robots from failing. “So the thing they’re worried about with Spot is, what is its tolerance? What components will fail, and what can we do to harden it?” he says. “We’re approaching Boston Dynamics at the moment to see if they’ll work with us to address some of those questions.

There’s been a small amount of testing of how robots fair under harsh radiation, Megson-Smith told us, including (relatively recently) a KUKA LBR800 arm, which “stopped operating after a large radiation dose of 164.55(±1.09) Gy to its end effector, and the component causing the failure was an optical encoder.” And in case you’re wondering how much radiation that is, a 1 to 2 Gy dose to the entire body gets you acute radiation sickness and possibly death, while 8 Gy is usually just straight-up death. The goal here is not to kill robots (I mean, it sort of is), but as Megson-Smith says, “if we can work out what the weak points are in a robotic system, can we address those, can we redesign those, or at least understand when they might start to fail?” Now all he has to do is convince Boston Dynamics to send them a Spot that they can zap until it keels over.

The goal for Spot in the short term is fully autonomous radiation mapping, which seems very possible. It’ll also get tested with a wider range of sensor packages, and (happily for the robot) this will all take place safely back at home in the U.K. As far as Chernobyl is concerned, robots will likely have a substantial role to play in the near future. “Ultimately, Chernobyl has to be taken apart and decommissioned. That’s the long-term plan for the facility. To do that, you first need to understand everything, which is where we come in with our sensor systems and robotic platforms,” Megson-Smith tells us. “Since there are entire swathes of the Chernobyl nuclear plant where people can’t go in, we’d need robots like Spot to do those environmental characterizations.” Continue reading

Posted in Human Robots

#437635 Toyota Research Demonstrates ...

Over the last several years, Toyota has been putting more muscle into forward-looking robotics research than just about anyone. In addition to the Toyota Research Institute (TRI), there’s that massive 175-acre robot-powered city of the future that Toyota still plans to build next to Mount Fuji. Even Toyota itself acknowledges that it might be crazy, but that’s just how they roll—as TRI CEO Gill Pratt told me a while back, when Toyota decides to do something, they really do go all-in on it.

TRI has been focusing heavily on home robots, which is reflective of the long-term nature of what TRI is trying to do, because home robots are both the place where we’ll need robots the most at the same time as they’re the place where it’s going to be hardest to deploy them. The unpredictable nature of homes, and the fact that homes tend to have squishy fragile people in them, are robot-unfriendly characteristics, but as the population continues to age (an increasingly acute problem in Japan), homes offer an enormous amount of potential for helping us maintain our independence.

Today, Toyota is showing off some of the research that it’s been working on recently, in the form of a virtual reality presentation in lieu of an in-person press event. For journalists, TRI pre-loaded the recording onto a VR headset, which was FedEx’ed to my house. You can watch the entire 40-minute presentation in 360 video on YouTube (or in VR if you have a headset of your own), but if you don’t watch the whole thing, you should at least check out the full-on GLaDOS (with arms) that TRI thinks belongs in your home.

The presentation features an introduction from Gill Pratt, who looks entirely too comfortable embedded inside of one of TRI’s telepresence robots. The event also covers a lot of territory, but the highlight is almost certainly the new hardware that TRI demonstrates.

Soft bubble gripper

Photo: TRI

This is a “soft bubble gripper,” under development at TRI’s Cambridge, Mass., branch. These passively-compliant, air-filled grippers make it easier to grasp many different kinds of objects safely, but the nifty thing is that they’ve got cameras inside of them watching a pattern of dots on the interior of the soft membrane.

When the outside of the bubble makes contact with an object, the bubble deforms, and the deformation of the dot pattern on the inside can be tracked by the camera to determine both directions and magnitudes of forces. This is a concept that we’ve seen elsewhere before, but TRI’s implementation is a clever way of making an inherently safe end effector that can still perform all the sensing you need it to do for relatively complex manipulation tasks.

The bubble gripper was presented at ICRA this year, and you can read the technical paper here.

Ceiling-mounted home robot

Photo: TRI

I don’t know whether robots dangling from the ceiling was somehow sinister pre-Portal, but it sure as heck is for me having played through that game a couple of times, and it’s since been reinforced by AUTO from WALL-E.

The reason that we generally see robots mounted on the floor or on tables or on mobile bases is that we’re bipeds, not bats, and giving a robot access to a human-like workspace is easiest to do if you also give that robot a human-like position and orientation. And if you want to be able to reach stuff high up, you do what TRI did with their previous generation of kitchen manipulator, and just give it the ability to make itself super tall. But TRI is convinced it’s a good place to put our future home robots:

One innovative concept is a “gantry robot” that would descend from an overhead framework to perform tasks such as loading the dishwasher, wiping surfaces, and clearing clutter. By traveling on the ceiling, the robot avoids the problems of navigating household floor clutter and navigating cramped spaces. When not in use, the robot would tuck itself up out of the way. To further investigate this idea, the team has built a laboratory prototype robot that can do all the same tasks as a floor-based mobile robot but with the innovative overhead mobility system.

Another obvious problem with the gantry robot is that you have to install all kinds of stuff in your ceiling for this to work, which makes it very impractical (if not totally impossible) to introduce a system like this into a home that wasn’t built specifically for it. If, however, you do build a home with a robot like this in mind, the animation below from TRI shows how it could be extra useful. Suddenly, stairs are a non-issue. Payload is presumably also a non-issue, since loads can be transferred to the ceiling. Batteries become unnecessary, so the whole robot can be much lighter weight, which in turn makes it safer. Sensors get a fantastic view, and obstacle avoidance becomes trivial.

Robots as “time machines”

Photo: TRI

TRI’s presentation covered more than what we’ve highlighted here—our focus has been on the hardware prototypes, but TRI had more to talk about, including learning through demonstration, scaling learning through simulation, and how TRI has been working with users to figure out what research directions should be explored. It’s all available right now on YouTube, and it’s well worth 40 minutes of your time.

“What we’re really focused on is this principle idea of amplifying, rather than replacing, human beings”
—Gill Pratt, TRI

It’s only been five years since Toyota announced the $1 billion investment that established TRI, and it feels like the progress that’s been made since then has been substantial. It’s not often that vision, resources, and long-term commitment come together like this, and TRI’s emphasis on making life better for people is one of the things that helps to keep us optimistic about the future of robotics.

“What we’re really focused on is this principle idea of amplifying, rather than replacing, human beings,” Gill Pratt told us. “And what it means to amplify a person, particularly as they’re aging—what we’re really trying to do is build a time machine. This may sound fanciful, and of course we can’t build a real time machine, but maybe we can build robotic assistants to make our lives as we age seem as if we are actually using a time machine.” He explains that it doesn’t mean building robots for convenience or to do our jobs for us. “It means building technology that enables us to continue to live and to work and to relate to each other as if we were younger,” he says. “And that’s really what our main goal is.” Continue reading

Posted in Human Robots