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#431058 How to Make Your First Chatbot With the ...

You’re probably wondering what Game of Thrones has to do with chatbots and artificial intelligence. Before I explain this weird connection, I need to warn you that this article may contain some serious spoilers. Continue with your reading only if you are a passionate GoT follower, who watches new episodes immediately after they come out.
Why are chatbots so important anyway?
According to the study “When Will AI Exceed Human Performance?,” researchers believe there is a 50% chance artificial intelligence could take over all human jobs by around the year 2060. This technology has already replaced dozens of customer service and sales positions and helped businesses make substantial savings.
Apart from the obvious business advantages, chatbot creation can be fun. You can create an artificial personality with a strong attitude and a unique set of traits and flaws. It’s like creating a new character for your favorite TV show. That’s why I decided to explain the most important elements of the chatbot creation process by using the TV characters we all know and love (or hate).
Why Game of Thrones?
Game of Thrones is the most popular TV show in the world. More than 10 million viewers watched the seventh season premiere, and you have probably seen internet users fanatically discussing the series’ characters, storyline, and possible endings.
Apart from writing about chatbots, I’m also a GoT fanatic, and I will base this chatbot on one of the characters from my favorite series. But before you find out the name of my bot, you should read a few lines about incredible free tools that allow us to build chatbots without coding.
Are chatbots expensive?
Today, you can create a chatbot even if you don’t know how to code. Most chatbot building platforms offer at least one free plan that allows you to use basic functionalities, create your bot, deploy it to Facebook Messenger, and analyze its performance. Free plans usually allow your bot to talk to a limited number of users.
Why should you personalize your bot?
Every platform will ask you to write a bot’s name before you start designing conversations. You will also be able to add the bot’s photograph and bio. Personalizing your bot is the only way to ensure that you will stick to the same personality and storyline throughout the building process. Users often see chatbots as people, and by giving your bot an identity, you will make sure that it doesn’t sound like it has multiple personality disorder.
I think connecting my chatbot with a GoT character will help readers understand the process of chatbot creation.
And the name of our GoT chatbot is…
…Cersei. She is mean, pragmatic, and fearless and she would do anything to stay on the Iron Throne. Many people would rather hang out with Daenerys or Jon Snow. These characters are honest, noble and good-hearted, which means their actions are often predictable.
Cersei, on the other hand, is the queen of intrigues. As the meanest and the most vengeful character in the series, she has an evil plan for everybody who steps on her toes. While viewers can easily guess where Jon and Daenerys stand, there are dozens of questions they would like to ask Cersei. But before we start talking to our bot, we need to build her personality by using the most basic elements of chatbot interaction.
Choosing the bot’s name on Botsify.
Welcome / Greeting Message
The welcome message is the greeting Cersei says to every commoner who clicks on the ‘start conversation’ button. She is not a welcoming person (ask Sansa), except if you are a banker from Braavos. Her introductory message may sound something like this:
“Dear {{user_full_name}}, My name is Cersei of the House Lannister, the First of Her Name, Queen of the Andals and the First Men, Protector of the Seven Kingdoms. You can ask me questions, and I will answer them. If the question is not worth answering, I will redirect you to Ser Gregor Clegane, who will give you a step-by-step course on how to talk to the Queen of Westeros.”
Creating the welcome message on Chatfuel
Default Message / Answer
In the bot game, users, bots, and their creators often need to learn from failed attempts and mistakes. The default message is the text Cersei will send whenever you ask her a question she doesn’t understand. Knowing Cersei, it would sound something like this:
“Ser Gregor, please escort {{user_full_name}} to the dungeon.”
Creating default message on Botsify
Menu
To avoid calling out the Mountain every time someone asks her a question, Cersei might give you a few (safe) options to choose. The best way to do this is by using a menu function. We can classify the questions people want to ask Cersei in several different categories:

Iron Throne
Relationship with Jaime — OK, this isn’t a “safe option,” get ready to get close and personal with Sir Gregor Clegane.
War plans
Euron Greyjoy

After users choose a menu item, Cersei can give them a default response on the topic or set up a plot that will make their lives miserable. Knowing Cersei, she will probably go for the second option.
Adding chatbot menu on Botsify
Stories / Blocks
This feature allows us to build a longer Cersei-to-user interaction. The structure of stories and blocks is different on every chatbot platform, but most of them use keywords and phrases for finding out the user’s intention.

Keywords — where the bot recognizes a certain keyword within the user’s reply. Users who have chosen the ‘war plans’ option might ask Cersei how is she planning to defeat Daenerys’s dragons. We can add ‘dragon’ and ‘dragons’ as keywords, and connect them with an answer that will sound something like this:

“Dragons are not invulnerable as you may think. Maester Qyburn is developing a weapon that will bring them down for good!”
Adding keywords on Chatfuel
People may also ask her about White Walkers. Do you plan to join Daenerys and Jon Snow in a fight against White Walkers? After we add ‘White Walker’ and ‘White Walkers’ on the keyword list, Cersei will answer:
“White Walkers? Do you think the Queen of Westeros has enough free time to think about creatures from fairy tales and legends?”
Adding Keywords on Botsify

Phrases — are more complex syntaxes that the bot can be trained to recognize. Many people would like to ask Cersei if she’s going to marry Euron Greyjoy after the war ends. We can add ‘Euron’ as a keyword, but then we won’t be sure what answer the user is expecting. Instead, we can use the phrase ‘(Will you) marry Euron Greyjoy (after the war?)’. Just to be sure, we should also add a few alternative phrases like ‘(Do you plan on) marrying Euron Greyjoy (after the war),’ ‘(Will you) end up with Euron Greyjoy (after the war?)’, ‘(Will) Euron Greyjoy be the new King?’ etc. Cersei would probably answer this inquiry in her style:

“Of course not, Euron is a useful idiot. I will use his fleet and send him back to the Iron Islands, where he belongs.”
Adding phrases on Botsify
Forms
We have already asked Cersei several questions, and now she would like to ask us something. She can do so by using the form/user input feature. Most tools allow us to add a question and the criteria for checking the users’ answer. If the user provides us the answer that is compliant to the predefined form (like email address, phone number, or a ZIP code), the bot will identify and extract the answer. If the answer doesn’t fit into the predefined criteria, the bot will notify the user and ask him/her to try again.
If Cersei would ask you a question, she would probably want to know your address so she could send her guards to fill your basement with barrels of wildfire.
Creating forms on Botsify
Templates
If you have problems building your first chatbot, templates can help you create the basic conversation structure. Unfortunately, not all platforms offer this feature for free. Snatchbot currently has the most comprehensive list of free templates. There you can choose a pre-built layout. The template selection ranges from simple FAQ bots to ones created for a specific industry, like banking, airline, healthcare, or e-commerce.
Choosing templates on Snatchbot
Plugins
Most tools also provide plugins that can be used for making the conversations more meaningful. These plugins allow Cersei to send images, audio and video files. She can unleash her creativity and make you suffer by sending you her favorite GoT execution videos.

With the help of integrations, Cersei can talk to you on Facebook Messenger, Telegram, WeChat, Slack, and many other communication apps. She can also sell her fan gear and ask you for donations by integrating in-bot payments from PayPal accounts. Her sales pitch will probably sound something like this:
“Gold wins wars! Would you rather invest your funds in a member of a respected family, who always pays her debts, or in the chaotic war endeavor of a crazy revolutionary, whose strength lies in three flying lizards? If your pockets are full of gold, you are already on my side. Now you can complete your checkout on PayPal.”
Chatbot building is now easier than ever, and even small businesses are starting to use the incredible benefits of artificial intelligence. If you still don’t believe that chatbots can replace customer service representatives, I suggest you try to develop a bot based on your favorite TV show, movie or book character and talk with him/her for a while. This way, you will be able to understand the concept that stands behind this amazing technology and use it to improve your business.
Now I’m off to talk to Cersei. Maybe she will feed me some Season 8 spoilers.
This article was originally published by Chatbots Magazine. Read the original post here.
Image credits for screenshots in post: Branislav Srdanovic
Banner stock media provided by new_vision_studio / Pond5 Continue reading

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#431023 Finish Him! MegaBots’ Giant Robot Duel ...

It began two years ago when MegaBots co-founders Matt Oehrlein and Gui Cavalcanti donned American flags as capes and challenged Suidobashi Heavy Industries to a giant robot duel in a YouTube video that immediately went viral.
The battle proposed: MegaBots’ 15-foot tall, 1,200-pound MK2 robot vs. Suidobashi’s 9,000-pound robot, KURATAS. Oehrlein and Cavalcanti first discovered the KURATAS robot in a listing on Amazon with a million-dollar price tag.
In an equally flamboyant response video, Suidobashi CEO and founder Kogoro Kurata accepted the challenge. (Yes, he named his robot after himself.) Both parties planned to take a year to prepare their robots for combat.
In the end, it took twice the amount of time. Nonetheless, the battle is going down this September in an undisclosed location.
Oehrlein shared more about the much-anticipated showdown during our interview at Singularity University’s Global Summit.

Two years since the initial video, MegaBots has now completed the combat-capable MK3 robot, named Eagle Prime. This new 12-ton, 16-foot-tall robot is powered by a 430-horsepower Corvette engine and requires two human pilots.
It’s also the robot they recently shipped to take on KURATAS.

Building Eagle Prime has been no small feat. With arms and legs that each weigh as much as a car, assembling the robot takes forklifts, cranes, and a lot of caution. Fortress One, MegaBots’ headquarters in Hayward, California is where the magic happens.
In terms of “weaponry,” Eagle Prime features a giant pneumatic cannon that shoots huge paint cannonballs. Oehrlein warns, “They can shatter all the windows in a car. It’s very powerful.” A logging grapple, which looks like a giant claw and exerts 3,000 pounds of steel-crushing force, has also been added to the robot.

“It’s a combination of range combat, using the paint balls to maybe blind cameras on the other robot or take out sensitive electronics, and then closing in with the claw and trying to disable their systems at close range,” Oehrlein explains.
Safety systems include a cockpit roll cage for the two pilots, five-point safety seatbelt harnesses, neck restraints, helmets, and flame retardant suits.
Co-founder, Matt Oehrlein, inside the cockpit of MegaBots’ Eagle Prime giant robot.
Oehrlein and Cavalcanti have also spent considerable time inside Eagle Prime practicing battlefield tactics and maneuvering the robot through obstacle courses.
Suidobashi’s robot is a bit shorter and lighter, but also a little faster, so the battle dynamics should be interesting.
You may be thinking, “Why giant dueling robots?”
MegaBots’ grand vision is a full-blown international sports league of giant fighting robots on the scale of Formula One racing. Picture a nostalgic evening sipping a beer (or three) and watching Pacific Rim- and Power Rangers-inspired robots battle—only in real life.
Eagle Prime is, in good humor, a proudly patriotic robot.
“Japan is known as a robotic powerhouse,” says Oehrlein, “I think there’s something interesting about the slightly overconfident American trying to get a foothold in the robotics space and doing it by building a bigger, louder, heavier robot, in true American fashion.”
For safety reasons, no fans will be admitted during the time of the fight. The battle will be posted after the fact on MegaBots’ YouTube channel and Facebook page.
We’ll soon find out whether this becomes another American underdog story.
In the meantime, I give my loyalty to MegaBots, and in the words of Mortal Kombat, say, “Finish him!”

via GIPHY
Image Credit: MegaBots Continue reading

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#431015 Finish Him! MegaBots’ Giant Robot Duel ...

It began two years ago when MegaBots co-founders Matt Oehrlein and Gui Cavalcanti donned American flags as capes and challenged Suidobashi Heavy Industries to a giant robot duel in a YouTube video that immediately went viral.
The battle proposed: MegaBots’ 15-foot tall, 1,200-pound MK2 robot vs. Suidobashi’s 9,000-pound robot, KURATAS. Oehrlein and Cavalcanti first discovered the KURATAS robot in a listing on Amazon with a million-dollar price tag.
In an equally flamboyant response video, Suidobashi CEO and founder Kogoro Kurata accepted the challenge. (Yes, he named his robot after himself.) Both parties planned to take a year to prepare their robots for combat.
In the end, it took twice the amount of time. Nonetheless, the battle is going down this September in an undisclosed location in Japan.
Oehrlein shared more about the much-anticipated showdown during our interview at Singularity University’s Global Summit.

Two years since the initial video, MegaBots has now completed the combat-capable MK3 robot, named Eagle Prime. This new 12-ton, 16-foot-tall robot is powered by a 430-horsepower Corvette engine and requires two human pilots.
It’s also the robot they recently shipped to Japan to take on KURATAS.

Building Eagle Prime has been no small feat. With arms and legs that each weigh as much as a car, assembling the robot takes forklifts, cranes, and a lot of caution. Fortress One, MegaBots’ headquarters in Hayward, California is where the magic happens.
In terms of “weaponry,” Eagle Prime features a giant pneumatic cannon that shoots huge paint cannonballs. Oehrlein warns, “They can shatter all the windows in a car. It’s very powerful.” A logging grapple, which looks like a giant claw and exerts 3,000 pounds of steel-crushing force, has also been added to the robot.
“It’s a combination of range combat, using the paint balls to maybe blind cameras on the other robot or take out sensitive electronics, and then closing in with the claw and trying to disable their systems at close range,” Oehrlein explains.
Safety systems include a cockpit roll cage for the two pilots, five-point safety seatbelt harnesses, neck restraints, helmets, and flame retardant suits.
Co-founder, Matt Oehrlein, inside the cockpit of MegaBots’ Eagle Prime giant robot.
Oehrlein and Cavalcanti have also spent considerable time inside Eagle Prime practicing battlefield tactics and maneuvering the robot through obstacle courses.
Suidobashi’s robot is a bit shorter and lighter, but also a little faster, so the battle dynamics should be interesting.
You may be thinking, “Why giant dueling robots?”
MegaBots’ grand vision is a full-blown international sports league of giant fighting robots on the scale of Formula One racing. Picture a nostalgic evening sipping a beer (or three) and watching Pacific Rim- and Power Rangers-inspired robots battle—only in real life.
Eagle Prime is, in good humor, a proudly patriotic robot.
“Japan is known as a robotic powerhouse,” says Oehrlein, “I think there’s something interesting about the slightly overconfident American trying to get a foothold in the robotics space and doing it by building a bigger, louder, heavier robot, in true American fashion.”
For safety reasons, no fans will be admitted during the time of the fight. The battle will be posted after the fact on MegaBots’ YouTube channel and Facebook page.
We’ll soon find out whether this becomes another American underdog story.
In the meantime, I give my loyalty to MegaBots, and in the words of Mortal Kombat, say, “Finish him!”

via GIPHY
Image Credit: MegaBots Continue reading

Posted in Human Robots

#430868 These 7 Forces Are Changing the World at ...

It was the Greek philosopher Heraclitus who first said, “The only thing that is constant is change.”
He was onto something. But even he would likely be left speechless at the scale and pace of change the world has experienced in the past 100 years—not to mention the past 10.
Since 1917, the global population has gone from 1.9 billion people to 7.5 billion. Life expectancy has more than doubled in many developing countries and risen significantly in developed countries. In 1917 only eight percent of homes had phones—in the form of landline telephones—while today more than seven in 10 Americans own a smartphone—aka, a supercomputer that fits in their pockets.
And things aren’t going to slow down anytime soon. In a talk at Singularity University’s Global Summit this week in San Francisco, SU cofounder and chairman Peter Diamandis told the audience, “Tomorrow’s speed of change will make today look like we’re crawling.” He then shared his point of view about some of the most important factors driving this accelerating change.
Peter Diamandis at Singularity University’s Global Summit in San Francisco.
Computation
In 1965, Gordon Moore (cofounder of Intel) predicted computer chips would double in power and halve in cost every 18 to 24 months. What became known as Moore’s Law turned out to be accurate, and today affordable computer chips contain a billion or more transistors spaced just nanometers apart.
That means computers can do exponentially more calculations per second than they could thirty, twenty, or ten years ago—and at a dramatically lower cost. This in turn means we can generate a lot more information, and use computers for all kinds of applications they wouldn’t have been able to handle in the past (like diagnosing rare forms of cancer, for example).
Convergence
Increased computing power is the basis for a myriad of technological advances, which themselves are converging in ways we couldn’t have imagined a couple decades ago. As new technologies advance, the interactions between various subsets of those technologies create new opportunities that accelerate the pace of change much more than any single technology can on its own.
A breakthrough in biotechnology, for example, might spring from a crucial development in artificial intelligence. An advance in solar energy could come about by applying concepts from nanotechnology.
Interface Moments
Technology is becoming more accessible even to the most non-techy among us. The internet was once the domain of scientists and coders, but these days anyone can make their own web page, and browsers make those pages easily searchable. Now, interfaces are opening up areas like robotics or 3D printing.
As Diamandis put it, “You don’t need to know how to code to 3D print an attachment for your phone. We’re going from mind to materialization, from intentionality to implication.”
Artificial intelligence is what Diamandis calls “the ultimate interface moment,” enabling everyone who can speak their mind to connect and leverage exponential technologies.
Connectivity
Today there are about three billion people around the world connected to the internet—that’s up from 1.8 billion in 2010. But projections show that by 2025 there will be eight billion people connected. This is thanks to a race between tech billionaires to wrap the Earth in internet; Elon Musk’s SpaceX has plans to launch a network of 4,425 satellites to get the job done, while Google’s Project Loon is using giant polyethylene balloons for the task.
These projects will enable five billion new minds to come online, and those minds will have access to exponential technologies via interface moments.
Sensors
Diamandis predicts that after we establish a 5G network with speeds of 10–100 Gbps, a proliferation of sensors will follow, to the point that there’ll be around 100,000 sensors per city block. These sensors will be equipped with the most advanced AI, and the combination of these two will yield an incredible amount of knowledge.
“By 2030 we’re heading towards 100 trillion sensors,” Diamandis said. “We’re heading towards a world in which we’re going to be able to know anything we want, anywhere we want, anytime we want.” He added that tens of thousands of drones will hover over every major city.
Intelligence
“If you think there’s an arms race going on for AI, there’s also one for HI—human intelligence,” Diamandis said. He explained that if a genius was born in a remote village 100 years ago, he or she would likely not have been able to gain access to the resources needed to put his or her gifts to widely productive use. But that’s about to change.
Private companies as well as military programs are working on brain-machine interfaces, with the ultimate aim of uploading the human mind. The focus in the future will be on increasing intelligence of individuals as well as companies and even countries.
Wealth Concentration
A final crucial factor driving mass acceleration is the increase in wealth concentration. “We’re living in a time when there’s more wealth in the hands of private individuals, and they’re willing to take bigger risks than ever before,” Diamandis said. Billionaires like Mark Zuckerberg, Jeff Bezos, Elon Musk, and Bill Gates are putting millions of dollars towards philanthropic causes that will benefit not only themselves, but humanity at large.
What It All Means
One of the biggest implications of the rate at which the world is changing, Diamandis said, is that the cost of everything is trending towards zero. We are heading towards abundance, and the evidence lies in the reduction of extreme poverty we’ve already seen and will continue to see at an even more rapid rate.
Listening to Diamandis’ optimism, it’s hard not to find it contagious.

“The world is becoming better at an extraordinary rate,” he said, pointing out the rises in literacy, democracy, vaccinations, and life expectancy, and the concurrent decreases in child mortality, birth rate, and poverty.
“We’re alive during a pivotal time in human history,” he concluded. “There is nothing we don’t have access to.”
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#430830 Biocomputers Made From Cells Can Now ...

When it comes to biomolecules, RNA doesn’t get a lot of love.
Maybe you haven’t even heard of the silent workhorse. RNA is the cell’s de facto translator: like a game of telephone, RNA takes DNA’s genetic code to a cellular factory called ribosomes. There, the cell makes proteins based on RNA’s message.
But RNA isn’t just a middleman. It controls what proteins are formed. Because proteins wiz around the cell completing all sorts of important processes, you can say that RNA is the gatekeeper: no RNA message, no proteins, no life.
In a new study published in Nature, RNA finally took center stage. By adding bits of genetic material to the E. Coli bacteria, a team of biohackers at the Wyss Institute hijacked the organism’s RNA messengers so that they only spring into action following certain inputs.
The result? A bacterial biocomputer capable of performing 12-input logic operations—AND, OR, and NOT—following specific inputs. Rather than outputting 0s and 1s, these biocircuits produce results based on the presence or absence of proteins and other molecules.
“It’s the greatest number of inputs in a circuit that a cell has been able to process,” says study author Dr. Alexander Green at Arizona State University. “To be able to analyze those signals and make a decision is the big advance here.”
When given a specific set of inputs, the bacteria spit out a protein that made them glow neon green under fluorescent light.
But synthetic biology promises far more than just a party trick—by tinkering with a cell’s RNA repertoire, scientists may one day coax them to photosynthesize, produce expensive drugs on the fly, or diagnose and hunt down rogue tumor cells.
Illustration of an RNA-based ‘ribocomputing’ device that makes logic-based decisions in living cells. The long gate RNA (blue) detects the binding of an input RNA (red). The ribosome (purple/mauve) reads the gate RNA to produce an output protein. Image Credit: Alexander Green / Arizona State University
The software of life
This isn’t the first time that scientists hijacked life’s algorithms to reprogram cells into nanocomputing systems. Previous work has already introduced to the world yeast cells that can make anti-malaria drugs from sugar or mammalian cells that can perform Boolean logic.
Yet circuits with multiple inputs and outputs remain hard to program. The reason is this: synthetic biologists have traditionally focused on snipping, fusing, or otherwise arranging a cell’s DNA to produce the outcomes they want.
But DNA is two steps removed from proteins, and tinkering with life’s code often leads to unexpected consequences. For one, the cell may not even accept and produce the extra bits of DNA code. For another, the added code, when transformed into proteins, may not act accordingly in the crowded and ever-changing environment of the cell.
What’s more, tinkering with one gene is often not enough to program an entirely new circuit. Scientists often need to amp up or shut down the activity of multiple genes, or multiple biological “modules” each made up of tens or hundreds of genes.
It’s like trying to fit new Lego pieces in a specific order into a room full of Lego constructions. Each new piece has the potential to wander off track and click onto something it’s not supposed to touch.
Getting every moving component to work in sync—as you might have guessed—is a giant headache.
The RNA way
With “ribocomputing,” Green and colleagues set off to tackle a main problem in synthetic biology: predictability.
Named after the “R (ribo)” in “RNA,” the method grew out of an idea that first struck Green back in 2012.
“The synthetic biological circuits to date have relied heavily on protein-based regulators that are difficult to scale up,” Green wrote at the time. We only have a limited handful of “designable parts” that work well, and these circuits require significant resources to encode and operate, he explains.
RNA, in comparison, is a lot more predictable. Like its more famous sibling DNA, RNA is composed of units that come in four different flavors: A, G, C, and U. Although RNA is only single-stranded, rather than the double helix for which DNA is known for, it can bind short DNA-like sequences in a very predictable manner: Gs always match up with Cs and As always with Us.
Because of this predictability, it’s possible to design RNA components that bind together perfectly. In other words, it reduces the chance that added RNA bits might go rogue in an unsuspecting cell.
Normally, once RNA is produced it immediately rushes to the ribosome—the cell’s protein-building factory. Think of it as a constantly “on” system.
However, Green and his team found a clever mechanism to slow them down. Dubbed the “toehold switch,” it works like this: the artificial RNA component is first incorporated into a chain of A, G, C, and U folded into a paperclip-like structure.
This blocks the RNA from accessing the ribosome. Because one RNA strand generally maps to one protein, the switch prevents that protein from ever getting made.
In this way, the switch is set to “off” by default—a “NOT” gate, in Boolean logic.
To activate the switch, the cell needs another component: a “trigger RNA,” which binds to the RNA toehold switch. This flips it on: the RNA grabs onto the ribosome, and bam—proteins.
BioLogic gates
String a few RNA switches together, with the activity of each one relying on the one before, and it forms an “AND” gate. Alternatively, if the activity of each switch is independent, that’s an “OR” gate.
“Basically, the toehold switches performed so well that we wanted to find a way to best exploit them for cellular applications,” says Green. They’re “kind of the equivalent of your first transistors,” he adds.
Once the team optimized the designs for different logic gates, they carefully condensed the switches into “gate RNA” molecules. These gate RNAs contain both codes for proteins and the logic operations needed to kickstart the process—a molecular logic circuit, so to speak.
If you’ve ever played around with an Arduino-controlled electrical circuit, you probably know the easiest way to test its function is with a light bulb.
That’s what the team did here, though with a biological bulb: green fluorescent protein, a light-sensing protein not normally present in bacteria that—when turned on—makes the microbugs glow neon green.
In a series of experiments, Green and his team genetically inserted gate RNAs into bacteria. Then, depending on the type of logical function, they added different combinations of trigger RNAs—the inputs.
When the input RNA matched up with its corresponding gate RNA, it flipped on the switch, causing the cell to light up.

Their most complex circuit contained five AND gates, five OR gates, and two NOTs—a 12-input ribocomputer that functioned exactly as designed.
That’s quite the achievement. “Everything is interacting with everything else and there are a million ways those interactions could flip the switch on accident,” says RNA researcher Dr. Julies Lucks at Northwestern University.
The specificity is thanks to RNA, the authors explain. Because RNAs bind to others so predictably, we can now design massive libraries of gate and trigger units to mix-and-match into all types of nano-biocomputers.
RNA BioNanobots
Although the technology doesn’t have any immediate applications, the team has high hopes.
For the first time, it’s now possible to massively scale up the process of programming new circuits into living cells. We’ve expanded the library of available biocomponents that can be used to reprogram life’s basic code, the authors say.
What’s more, when freeze-dried onto a piece of tissue paper, RNA keeps very well. We could potentially print RNA toehold switches onto paper that respond to viruses or to tumor cells, the authors say, essentially transforming the technology into highly accurate diagnostic platforms.
But Green’s hopes are even wilder for his RNA-based circuits.
“Because we’re using RNA, a universal molecule of life, we know these interactions can also work in other cells, so our method provides a general strategy that could be ported to other organisms,” he says.
Ultimately, the hope is to program neural network-like capabilities into the body’s other cells.
Imagine cells endowed with circuits capable of performing the kinds of computation the brain does, the authors say.
Perhaps one day, synthetic biology will transform our own cells into fully programmable entities, turning us all into biological cyborgs from the inside. How wild would that be?
Image Credit: Wyss Institute at Harvard University Continue reading

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