Tag Archives: therapy
#437643 Video Friday: Matternet Launches Urban ...
Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):
IROS 2020 – October 25-25, 2020 – [Online]
Bay Area Robotics Symposium – November 20, 2020 – [Online]
ACRA 2020 – December 8-10, 2020 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.
Sixteen teams chose their roster of virtual robots and sensor payloads, some based on real-life subterranean robots, and submitted autonomy and mapping algorithms that SubT Challenge officials then tested across eight cave courses in the cloud-based SubT Simulator. Their robots traversed the cave environments autonomously, without any input or adjustments from human operators. The Cave Circuit Virtual Competition teams earned points by correctly finding, identifying, and localizing up to 20 artifacts hidden in the cave courses within five-meter accuracy.
[ SubT ]
This year, the KUKA Innovation Award’s international jury of experts received a total of more than 40 ideas. The five finalist teams had time until November to implement their ideas. A KUKA LBR Med lightweight robot – the first robotic component to be certified for integration into a medical device – has been made available to them for this purpose. Beyond this, the teams have received a training for the hardware and coaching from KUKA experts throughout the competition. At virtual.MEDICA from 16-19.11.2020, the finalists presented their concepts to an international audience of experts and to the Innovation Award jury.
The winner of the KUKA Innovation Award 2020, worth 20,000 euros, is Team HIFUSK from the Scuola Superiore Sant'Anna in Italy.
[ KUKA Innovation Award ]
Like everything else the in-person Cybathlon event was cancelled, but the competition itself took place, just a little more distributed than it would have been otherwise.
[ Cybathlon ]
Matternet, developer of the world's leading urban drone logistics platform, today announced the launch of operations at Labor Berlin Charité Vivantes in Germany. The program kicked-off November 17, 2020 with permanent operations expected to take flight next year, creating the first urban BVLOS [Beyond Visual Line of Sight] medical drone delivery network in the European Union. The drone network expects to significantly improve the timeliness and efficiency of Labor Berlin’s diagnostics services by providing an option to avoid roadway delays, which will improve patient experience with potentially life-saving benefits and lower costs.
Routine BVLOS over an urban area? Impressive.
[ Matternet ]
Robots playing diabolo!
Thanks Thilo!
[ OMRON Sinic X]
Anki's tech has been repackaged into this robot that serves butter:
[ Butter Robot ]
Berkshire Grey just announced our Picking With Purpose Program in which we’ve partnered our robotic automation solutions with food rescue organizations City Harvest and The Greater Boston Food Bank to pick, pack, and distribute food to families in need in time for Thanksgiving. Berkshire Grey donated about 40,000 pounds of food, used one of our robotic automation systems to pick and pack that food into meal boxes for families in need, and our team members volunteered to run the system. City Harvest and The Greater Boston Food Bank are distributing the 4,000 meal boxes we produced. This is just the beginning. We are building a sponsorship program to make Picking With Purpose an ongoing initiative.
[ Berkshire Grey ]
Thanks Peter!
We posted a video previously of Cassie learning to skip, but here's a much more detailed look (accompanying an ICRA submission) that includes some very impressive stair descending.
[ DRL ]
From garage inventors to university students and entrepreneurs, NASA is looking for ideas on how to excavate the Moon’s icy regolith, or dirt, and deliver it to a hypothetical processing plant at the lunar South Pole. The NASA Break the Ice Lunar Challenge, a NASA Centennial Challenge, is now open for registration. The competition will take place over two phases and will reward new ideas and approaches for a system architecture capable of excavating and moving icy regolith and water on the lunar surface.
[ NASA ]
Adaptation to various scene configurations and object properties, stability and dexterity in robotic grasping manipulation is far from explored. This work presents an origami-based shape morphing fingertip design to actively tackle the grasping stability and dexterity problems. The proposed fingertip utilizes origami as its skeleton providing degrees of freedom at desired positions and motor-driven four-bar-linkages as its transmission components to achieve a compact size of the fingertip.
[ Paper ]
“If Roboy crashes… you die.”
[ Roboy ]
Traditionally lunar landers, as well as other large space exploration vehicles, are powered by solar arrays or small nuclear reactors. Rovers and small robots, however, are not big enough to carry their own dedicated power supplies and must be tethered to their larger counterparts via electrical cables. Tethering severely restricts mobility, and cables are prone to failure due to lunar dust (regolith) interfering with electrical contact points. Additionally, as robots become smaller and more complex, they are fitted with additional sensors that require more power, further exacerbating the problem. Lastly, solar arrays are not viable for charging during the lunar night. WiBotic is developing rapid charging systems and energy monitoring base stations for lunar robots, including the CubeRover – a shoebox-sized robot designed by Astrobotic – that will operate autonomously and charge wirelessly on the Moon.
[ WiBotic ]
Watching pick and place robots is my therapy.
[ Soft Robotics ]
It's really, really hard to beat liquid fuel for energy storage, as Quaternium demonstrates with their hybrid drone.
[ Quaternium ]
Thanks Gregorio!
State-of-the-art quadrotor simulators have a rigid and highly-specialized structure: either are they really fast, physically accurate, or photo-realistic. In this work, we propose a novel quadrotor simulator: Flightmare.
[ Flightmare ]
Drones that chuck fire-fighting balls into burning buildings, sure!
[ LARICS ]
If you missed ROS World, that's okay, because all of the talks are now online. Here's the opening keynote from Vivian Chu and Diligent robotics, along with a couple fun lightning talks.
[ ROS World 2020 ]
This week's CMU RI Seminar is by Chelsea Finn from Stanford University, on Data Scalability for Robot Learning.
Recent progress in robot learning has demonstrated how robots can acquire complex manipulation skills from perceptual inputs through trial and error, particularly with the use of deep neural networks. Despite these successes, the generalization and versatility of robots across environment conditions, tasks, and objects remains a major challenge. And, unfortunately, our existing algorithms and training set-ups are not prepared to tackle such challenges, which demand large and diverse sets of tasks and experiences. In this talk, I will discuss two central challenges that pertain to data scalability: first, acquiring large datasets of diverse and useful interactions with the world, and second, developing algorithms that can learn from such datasets. Then, I will describe multiple approaches that we might take to rethink our algorithms and data pipelines to serve these goals. This will include algorithms that allow a real robot to explore its environment in a targeted manner with minimal supervision, approaches that can perform robot reinforcement learning with videos of human trial-and-error experience, and visual model-based RL approaches that are not bottlenecked by their capacity to model everything about the world.
[ CMU RI ] Continue reading
#437209 A Renaissance of Genomics and Drugs Is ...
The causes of aging are extremely complex and unclear. But with longevity clinical trials increasing, more answers—and questions—are emerging than ever before.
With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to turn those answers into practical ways to extend our healthspan.
In this article, I’ll explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.
Genome Sequencing and Editing
Your genome is the software that runs your body. A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity for disease, your lifespan, and so on.
Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean. Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $1,500 in 2015.
Today, the cost of genome sequencing has dropped below $600, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.
This represents one of the most powerful and transformative technology revolutions in healthcare. When we understand your genome, we’ll be able to understand how to optimize “you.”
We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later article).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).
CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally occurring biological system discovered in 1987 called CRISPR/Cas9.
Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.
Here’s how it works. The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays. The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions. If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.
Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome. A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.
2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers have used CRISPR to genetically engineer cocaine resistance into mice, reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs, and reduce genetic deafness in mice.
Already this year, CRISPR-edited immune cells have been shown to successfully kill cancer cells in human patients. Researchers have discovered ways to activate CRISPR with light and use the gene-editing technology to better understand Alzheimer’s disease progression.
With great power comes great responsibility, and the opportunity for moral and ethical dilemmas. In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera. Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.
To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells. Because Jiankui forged ethical review documents and misled doctors in the process, he was sentenced to three years in prison and fined $429,000 last December.
Coupled with significant ethical conversations necessary for progress, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.
Senolytics, Nutraceuticals, and Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.
What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely. These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse. Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification to localized inflammatory conditions such as osteoarthritis to diminished lung function.
Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.
Prominent companies in the field include the following:
Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology, and pulmonary disease.
Oisin Biotechnologies is pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.
SIWA Therapeutics is working on an immunotherapy approach to the problem of senescent cells.
In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.
(1) Rapamycin
Originally extracted from bacteria found on Easter Island, rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division. Currently, rapamycin derivatives are widely used for immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.
PureTech Health subsidiary resTORbio (which went public in 2018) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.
Results of the drug’s recent clinical trial include decreased incidence of infection, improved influenza vaccination response, and a 30.6 percent decrease in respiratory tract infection.
Impressive, to say the least.
(2) Metformin
Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients. Researchers have found that metformin also reduces oxidative stress and inflammation, which otherwise increase as we age. There is strong evidence that metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.
Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of metformin’s protective effect against cancer.
(3) Nutraceuticals and NAD+
Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.
NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.
The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s first clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.
Conclusion
These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.
The next article in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.
We are edging closer toward a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?
Join Me
(1) A360 Executive Mastermind: If you’re an exponentially and abundance-minded entrepreneur who would like coaching directly from me, consider joining my Abundance 360 Mastermind, a highly selective community of 360 CEOs and entrepreneurs who I coach for 3 days every January in Beverly Hills, Ca. Through A360, I provide my members with context and clarity about how converging exponential technologies will transform every industry. I’m committed to running A360 for the course of an ongoing 25-year journey as a “countdown to the Singularity.”
If you’d like to learn more and consider joining our 2021 membership, apply here.
(2) Abundance-Digital Online Community: I’ve also created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is Singularity University’s ‘onramp’ for exponential entrepreneurs—those who want to get involved and play at a higher level. Click here to learn more.
(Both A360 and Abundance-Digital are part of Singularity University—your participation opens you to a global community.)
This article originally appeared on diamandis.com. Read the original article here.
Image Credit: Arek Socha from Pixabay Continue reading
#437128 Smarter, lighter exoskeletons to provide ...
In health technology, wearable robots are programmable devices designed to mechanically interact with the body of the wearer. Sometimes referred to as exoskeletons, their purpose is to support motor function for people with severe mobility impairments. But market adoption of exoskeletons has been limited due to factors such as the weight of the equipment and the sometimes inaccurate predictions of wearer's movements when walking on uneven ground or approaching an obstacle. However, recent advances in robotics, materials science and artificial intelligence could make these mobility assistance and rehabilitation tools more compact, lightweight and effective for the wearer. Continue reading