Tag Archives: the brain

#432036 The Power to Upgrade Our Own Biology Is ...

Posted on February 15, 2018 by Android

Upgrading our biology may sound like science fiction, but attempts to improve humanity actually date back thousands of years. Every day, we enhance ourselves through seemingly mundane activities such as exercising, meditating, or consuming performance-enhancing drugs, such as caffeine or adderall. However, the tools with which we upgrade our biology are improving at an accelerating rate and becoming increasingly invasive.

In recent decades, we have developed a wide array of powerful methods, such as genetic engineering and brain-machine interfaces, that are redefining our humanity. In the short run, such enhancement technologies have medical applications and may be used to treat many diseases and disabilities. Additionally, in the coming decades, they could allow us to boost our physical abilities or even digitize human consciousness.

What’s New?
Many futurists argue that our devices, such as our smartphones, are already an extension of our cortex and in many ways an abstract form of enhancement. According to philosophers Andy Clark and David Chalmers’ theory of extended mind, we use technology to expand the boundaries of the human mind beyond our skulls.

One can argue that having access to a smartphone enhances one’s cognitive capacities and abilities and is an indirect form of enhancement of its own. It can be considered an abstract form of brain-machine interface. Beyond that, wearable devices and computers are already accessible in the market, and people like athletes use them to boost their progress.

However, these interfaces are becoming less abstract.

Not long ago, Elon Musk announced a new company, Neuralink, with the goal of merging the human mind with AI. The past few years have seen remarkable developments in both the hardware and software of brain-machine interfaces. Experts are designing more intricate electrodes while programming better algorithms to interpret neural signals. Scientists have already succeeded in enabling paralyzed patients to type with their minds, and are even allowing brains to communicate with one another purely through brainwaves.

Ethical Challenges of Enhancement
There are many social and ethical implications of such advancements.

One of the most fundamental issues with cognitive and physical enhancement techniques is that they contradict the very definition of merit and success that society has relied on for millennia. Many forms of performance-enhancing drugs have been considered “cheating” for the longest time.

But perhaps we ought to revisit some of our fundamental assumptions as a society.

For example, we like to credit hard work and talent in a fair manner, where “fair” generally implies that an individual has acted in a way that has served him to merit his rewards. If you are talented and successful, it is considered to be because you chose to work hard and take advantage of the opportunities available to you. But by these standards, how much of our accomplishments can we truly be credited for?

For instance, the genetic lottery can have an enormous impact on an individual’s predisposition and personality, which can in turn affect factors such as motivation, reasoning skills, and other mental abilities. Many people are born with a natural ability or a physique that gives them an advantage in a particular area or predisposes them to learn faster. But is it justified to reward someone for excellence if their genes had a pivotal role in their path to success?

Beyond that, there are already many ways in which we take “shortcuts” to better mental performance. Seemingly mundane activities like drinking coffee, meditating, exercising, or sleeping well can boost one’s performance in any given area and are tolerated by society. Even the use of language can have positive physical and psychological effects on the human brain, which can be liberating to the individual and immensely beneficial to society at large. And let’s not forget the fact that some of us are born into more access to developing literacy than others.

Given all these reasons, one could argue that cognitive abilities and talents are currently derived more from uncontrollable factors and luck than we like to admit. If anything, technologies like brain-machine interfaces can enhance individual autonomy and allow one a choice of how capable they become.

As Karim Jebari points out (pdf), if a certain characteristic or trait is required to perform a particular role and an individual lacks this trait, would it be wrong to implement the trait through brain-machine interfaces or genetic engineering? How is this different from any conventional form of learning or acquiring a skill? If anything, this would be removing limitations on individuals that result from factors outside their control, such as biological predisposition (or even traits induced from traumatic experiences) to act or perform in a certain way.

Another major ethical concern is equality. As with any other emerging technology, there are valid concerns that cognitive enhancement tech will benefit only the wealthy, thus exacerbating current inequalities. This is where public policy and regulations can play a pivotal role in the impact of technology on society.

Enhancement technologies can either contribute to inequality or allow us to solve it. Educating and empowering the under-privileged can happen at a much more rapid rate, helping the overall rate of human progress accelerate. The “normal range” for human capacity and intelligence, however it is defined, could shift dramatically towards more positive trends.

Many have also raised concerns over the negative applications of government-led biological enhancement, including eugenics-like movements and super-soldiers. Naturally, there are also issues of safety, security, and well-being, especially within the early stages of experimentation with enhancement techniques.

Brain-machine interfaces, for instance, could have implications on autonomy. The interface involves using information extracted from the brain to stimulate or modify systems in order to accomplish a goal. This part of the process can be enhanced by implementing an artificial intelligence system onto the interface—one that exposes the possibility of a third party potentially manipulating individual’s personalities, emotions, and desires by manipulating the interface.

A Tool For Transcendence
It’s important to discuss these risks, not so that we begin to fear and avoid such technologies, but so that we continue to advance in a way that minimizes harm and allows us to optimize the benefits.

Stephen Hawking notes that “with genetic engineering, we will be able to increase the complexity of our DNA, and improve the human race.” Indeed, the potential advantages of modifying biology are revolutionary. Doctors would gain access to a powerful tool to tackle disease, allowing us to live longer and healthier lives. We might be able to extend our lifespan and tackle aging, perhaps a critical step to becoming a space-faring species. We may begin to modify the brain’s building blocks to become more intelligent and capable of solving grand challenges.

In their book Evolving Ourselves, Juan Enriquez and Steve Gullans describe a world where evolution is no longer driven by natural processes. Instead, it is driven by human choices, through what they call unnatural selection and non-random mutation. Human enhancement is bringing us closer to such a world—it could allow us to take control of our evolution and truly shape the future of our species.

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Posted in Human Robots

#432027 We Read This 800-Page Report on the ...

Posted on February 14, 2018 by Android

The longevity field is bustling but still fragmented, and the “silver tsunami” is coming.

That is the takeaway of The Science of Longevity, the behemoth first volume of a four-part series offering a bird’s-eye view of the longevity industry in 2017. The report, a joint production of the Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International, synthesizes the growing array of academic and industry ventures related to aging, healthspan, and everything in between.

This is huge, not only in scale but also in ambition. The report, totally worth a read here, will be followed by four additional volumes in 2018, covering topics ranging from the business side of longevity ventures to financial systems to potential tensions between life extension and religion.

And that’s just the first step. The team hopes to publish updated versions of the report annually, giving scientists, investors, and regulatory agencies an easy way to keep their finger on the longevity pulse.

“In 2018, ‘aging’ remains an unnamed adversary in an undeclared war. For all intents and purposes it is mere abstraction in the eyes of regulatory authorities worldwide,” the authors write.

That needs to change.

People often arrive at the field of aging from disparate areas with wildly diverse opinions and strengths. The report compiles these individual efforts at cracking aging into a systematic resource—a “periodic table” for longevity that clearly lays out emerging trends and promising interventions.

The ultimate goal? A global framework serving as a road map to guide the burgeoning industry. With such a framework in hand, academics and industry alike are finally poised to petition the kind of large-scale investments and regulatory changes needed to tackle aging with a unified front.

Infographic depicting many of the key research hubs and non-profits within the field of geroscience.
Image Credit: Longevity.International
The Aging Globe
The global population is rapidly aging. And our medical and social systems aren’t ready to handle this oncoming “silver tsunami.”

Take the medical field. Many age-related diseases such as Alzheimer’s lack effective treatment options. Others, including high blood pressure, stroke, lung or heart problems, require continuous medication and monitoring, placing enormous strain on medical resources.

What’s more, because disease risk rises exponentially with age, medical care for the elderly becomes a game of whack-a-mole: curing any individual disease such as cancer only increases healthy lifespan by two to three years before another one hits.

That’s why in recent years there’s been increasing support for turning the focus to the root of the problem: aging. Rather than tackling individual diseases, geroscience aims to add healthy years to our lifespan—extending “healthspan,” so to speak.

Despite this relative consensus, the field still faces a roadblock. The US FDA does not yet recognize aging as a bona fide disease. Without such a designation, scientists are banned from testing potential interventions for aging in clinical trials (that said, many have used alternate measures such as age-related biomarkers or Alzheimer’s symptoms as a proxy).

Luckily, the FDA’s stance is set to change. The promising anti-aging drug metformin, for example, is already in clinical trials, examining its effect on a variety of age-related symptoms and diseases. This report, and others to follow, may help push progress along.

“It is critical for investors, policymakers, scientists, NGOs, and influential entities to prioritize the amelioration of the geriatric world scenario and recognize aging as a critical matter of global economic security,” the authors say.

Biomedical Gerontology
The causes of aging are complex, stubborn, and not all clear.

But the report lays out two main streams of intervention with already promising results.

The first is to understand the root causes of aging and stop them before damage accumulates. It’s like meddling with cogs and other inner workings of a clock to slow it down, the authors say.

The report lays out several treatments to keep an eye on.

Geroprotective drugs is a big one. Often repurposed from drugs already on the market, these traditional small molecule drugs target a wide variety of metabolic pathways that play a role in aging. Think anti-oxidants, anti-inflammatory, and drugs that mimic caloric restriction, a proven way to extend healthspan in animal models.

More exciting are the emerging technologies. One is nanotechnology. Nanoparticles of carbon, “bucky-balls,” for example, have already been shown to fight viral infections and dangerous ion particles, as well as stimulate the immune system and extend lifespan in mice (though others question the validity of the results).

Blood is another promising, if surprising, fountain of youth: recent studies found that molecules in the blood of the young rejuvenate the heart, brain, and muscles of aged rodents, though many of these findings have yet to be replicated.

Rejuvenation Biotechnology
The second approach is repair and maintenance.

Rather than meddling with inner clockwork, here we force back the hands of a clock to set it back. The main example? Stem cell therapy.

This type of approach would especially benefit the brain, which harbors small, scattered numbers of stem cells that deplete with age. For neurodegenerative diseases like Alzheimer’s, in which neurons progressively die off, stem cell therapy could in theory replace those lost cells and mend those broken circuits.

Once a blue-sky idea, the discovery of induced pluripotent stem cells (iPSCs), where scientists can turn skin and other mature cells back into a stem-like state, hugely propelled the field into near reality. But to date, stem cells haven’t been widely adopted in clinics.

It’s “a toolkit of highly innovative, highly invasive technologies with clinical trials still a great many years off,” the authors say.

But there is a silver lining. The boom in 3D tissue printing offers an alternative approach to stem cells in replacing aging organs. Recent investment from the Methuselah Foundation and other institutions suggests interest remains high despite still being a ways from mainstream use.

A Disruptive Future
“We are finally beginning to see an industry emerge from mankind’s attempts to make sense of the biological chaos,” the authors conclude.

Looking through the trends, they identified several technologies rapidly gaining steam.

One is artificial intelligence, which is already used to bolster drug discovery. Machine learning may also help identify new longevity genes or bring personalized medicine to the clinic based on a patient’s records or biomarkers.

Another is senolytics, a class of drugs that kill off “zombie cells.” Over 10 prospective candidates are already in the pipeline, with some expected to enter the market in less than a decade, the authors say.

Finally, there’s the big gun—gene therapy. The treatment, unlike others mentioned, can directly target the root of any pathology. With a snip (or a swap), genetic tools can turn off damaging genes or switch on ones that promote a youthful profile. It is the most preventative technology at our disposal.

There have already been some success stories in animal models. Using gene therapy, rodents given a boost in telomerase activity, which lengthens the protective caps of DNA strands, live healthier for longer.

“Although it is the prospect farthest from widespread implementation, it may ultimately prove the most influential,” the authors say.

Ultimately, can we stop the silver tsunami before it strikes?

Perhaps not, the authors say. But we do have defenses: the technologies outlined in the report, though still immature, could one day stop the oncoming tidal wave in its tracks.

Now we just have to bring them out of the lab and into the real world. To push the transition along, the team launched Longevity.International, an online meeting ground that unites various stakeholders in the industry.

By providing scientists, entrepreneurs, investors, and policy-makers a platform for learning and discussion, the authors say, we may finally generate enough drive to implement our defenses against aging. The war has begun.

Read the report in full here, and watch out for others coming soon here. The second part of the report profiles 650 (!!!) longevity-focused research hubs, non-profits, scientists, conferences, and literature. It’s an enormously helpful resource—totally worth keeping it in your back pocket for future reference.

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Posted in Human Robots

#431999 Brain-Like Chips Now Beat the Human ...

Posted on February 8, 2018 by Android

Move over, deep learning. Neuromorphic computing—the next big thing in artificial intelligence—is on fire.

Just last week, two studies individually unveiled computer chips modeled after information processing in the human brain.

The first, published in Nature Materials, found a perfect solution to deal with unpredictability at synapses—the gap between two neurons that transmit and store information. The second, published in Science Advances, further amped up the system’s computational power, filling synapses with nanoclusters of supermagnetic material to bolster information encoding.

The result? Brain-like hardware systems that compute faster—and more efficiently—than the human brain.

“Ultimately we want a chip as big as a fingernail to replace one big supercomputer,” said Dr. Jeehwan Kim, who led the first study at MIT in Cambridge, Massachusetts.

Experts are hopeful.

“The field’s full of hype, and it’s nice to see quality work presented in an objective way,” said Dr. Carver Mead, an engineer at the California Institute of Technology in Pasadena not involved in the work.

Software to Hardware
The human brain is the ultimate computational wizard. With roughly 100 billion neurons densely packed into the size of a small football, the brain can deftly handle complex computation at lightning speed using very little energy.

AI experts have taken note. The past few years saw brain-inspired algorithms that can identify faces, falsify voices, and play a variety of games at—and often above—human capability.

But software is only part of the equation. Our current computers, with their transistors and binary digital systems, aren’t equipped to run these powerful algorithms.

That’s where neuromorphic computing comes in. The idea is simple: fabricate a computer chip that mimics the brain at the hardware level. Here, data is both processed and stored within the chip in an analog manner. Each artificial synapse can accumulate and integrate small bits of information from multiple sources and fire only when it reaches a threshold—much like its biological counterpart.

Experts believe the speed and efficiency gains will be enormous.

For one, the chips will no longer have to transfer data between the central processing unit (CPU) and storage blocks, which wastes both time and energy. For another, like biological neural networks, neuromorphic devices can support neurons that run millions of streams of parallel computation.

A “Brain-on-a-chip”
Optimism aside, reproducing the biological synapse in hardware form hasn’t been as easy as anticipated.

Neuromorphic chips exist in many forms, but often look like a nanoscale metal sandwich. The “bread” pieces are generally made of conductive plates surrounding a switching medium—a conductive material of sorts that acts like the gap in a biological synapse.

When a voltage is applied, as in the case of data input, ions move within the switching medium, which then creates conductive streams to stimulate the downstream plate. This change in conductivity mimics the way biological neurons change their “weight,” or the strength of connectivity between two adjacent neurons.

But so far, neuromorphic synapses have been rather unpredictable. According to Kim, that’s because the switching medium is often comprised of material that can’t channel ions to exact locations on the downstream plate.

“Once you apply some voltage to represent some data with your artificial neuron, you have to erase and be able to write it again in the exact same way,” explains Kim. “But in an amorphous solid, when you write again, the ions go in different directions because there are lots of defects.”

In his new study, Kim and colleagues swapped the jelly-like switching medium for silicon, a material with only a single line of defects that acts like a channel to guide ions.

The chip starts with a thin wafer of silicon etched with a honeycomb-like pattern. On top is a layer of silicon germanium—something often present in transistors—in the same pattern. This creates a funnel-like dislocation, a kind of Grand Canal that perfectly shuttles ions across the artificial synapse.

The researchers then made a neuromorphic chip containing these synapses and shot an electrical zap through them. Incredibly, the synapses’ response varied by only four percent—much higher than any neuromorphic device made with an amorphous switching medium.

In a computer simulation, the team built a multi-layer artificial neural network using parameters measured from their device. After tens of thousands of training examples, their neural network correctly recognized samples 95 percent of the time, just 2 percent lower than state-of-the-art software algorithms.

The upside? The neuromorphic chip requires much less space than the hardware that runs deep learning algorithms. Forget supercomputers—these chips could one day run complex computations right on our handheld devices.

A Magnetic Boost
Meanwhile, in Boulder, Colorado, Dr. Michael Schneider at the National Institute of Standards and Technology also realized that the standard switching medium had to go.

“There must be a better way to do this, because nature has figured out a better way to do this,” he says.

His solution? Nanoclusters of magnetic manganese.

Schneider’s chip contained two slices of superconducting electrodes made out of niobium, which channel electricity with no resistance. When researchers applied different magnetic fields to the synapse, they could control the alignment of the manganese “filling.”

The switch gave the chip a double boost. For one, by aligning the switching medium, the team could predict the ion flow and boost uniformity. For another, the magnetic manganese itself adds computational power. The chip can now encode data in both the level of electrical input and the direction of the magnetisms without bulking up the synapse.

It seriously worked. At one billion times per second, the chips fired several orders of magnitude faster than human neurons. Plus, the chips required just one ten-thousandth of the energy used by their biological counterparts, all the while synthesizing input from nine different sources in an analog manner.

The Road Ahead
These studies show that we may be nearing a benchmark where artificial synapses match—or even outperform—their human inspiration.

But to Dr. Steven Furber, an expert in neuromorphic computing, we still have a ways before the chips go mainstream.

Many of the special materials used in these chips require specific temperatures, he says. Magnetic manganese chips, for example, require temperatures around absolute zero to operate, meaning they come with the need for giant cooling tanks filled with liquid helium—obviously not practical for everyday use.

Another is scalability. Millions of synapses are necessary before a neuromorphic device can be used to tackle everyday problems such as facial recognition. So far, no deal.

But these problems may in fact be a driving force for the entire field. Intense competition could push teams into exploring different ideas and solutions to similar problems, much like these two studies.

If so, future chips may come in diverse flavors. Similar to our vast array of deep learning algorithms and operating systems, the computer chips of the future may also vary depending on specific requirements and needs.

It is worth developing as many different technological approaches as possible, says Furber, especially as neuroscientists increasingly understand what makes our biological synapses—the ultimate inspiration—so amazingly efficient.

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Posted in Human Robots

#431928 How Fast Is AI Progressing? Stanford’s ...

Posted on January 19, 2018 by Android

When? This is probably the question that futurists, AI experts, and even people with a keen interest in technology dread the most. It has proved famously difficult to predict when new developments in AI will take place. The scientists at the Dartmouth Summer Research Project on Artificial Intelligence in 1956 thought that perhaps two months would be enough to make “significant advances” in a whole range of complex problems, including computers that can understand language, improve themselves, and even understand abstract concepts.
Sixty years later, and these problems are not yet solved. The AI Index, from Stanford, is an attempt to measure how much progress has been made in artificial intelligence.
The index adopts a unique approach, and tries to aggregate data across many regimes. It contains Volume of Activity metrics, which measure things like venture capital investment, attendance at academic conferences, published papers, and so on. The results are what you might expect: tenfold increases in academic activity since 1996, an explosive growth in startups focused around AI, and corresponding venture capital investment. The issue with this metric is that it measures AI hype as much as AI progress. The two might be correlated, but then again, they may not.
The index also scrapes data from the popular coding website Github, which hosts more source code than anyone in the world. They can track the amount of AI-related software people are creating, as well as the interest levels in popular machine learning packages like Tensorflow and Keras. The index also keeps track of the sentiment of news articles that mention AI: surprisingly, given concerns about the apocalypse and an employment crisis, those considered “positive” outweigh the “negative” by three to one.
But again, this could all just be a measure of AI enthusiasm in general.
No one would dispute the fact that we’re in an age of considerable AI hype, but the progress of AI is littered by booms and busts in hype, growth spurts that alternate with AI winters. So the AI Index attempts to track the progress of algorithms against a series of tasks. How well does computer vision perform at the Large Scale Visual Recognition challenge? (Superhuman at annotating images since 2015, but they still can’t answer questions about images very well, combining natural language processing and image recognition). Speech recognition on phone calls is almost at parity.
In other narrow fields, AIs are still catching up to humans. Translation might be good enough that you can usually get the gist of what’s being said, but still scores poorly on the BLEU metric for translation accuracy. The AI index even keeps track of how well the programs can do on the SAT test, so if you took it, you can compare your score to an AI’s.
Measuring the performance of state-of-the-art AI systems on narrow tasks is useful and fairly easy to do. You can define a metric that’s simple to calculate, or devise a competition with a scoring system, and compare new software with old in a standardized way. Academics can always debate about the best method of assessing translation or natural language understanding. The Loebner prize, a simplified question-and-answer Turing Test, recently adopted Winograd Schema type questions, which rely on contextual understanding. AI has more difficulty with these.
Where the assessment really becomes difficult, though, is in trying to map these narrow-task performances onto general intelligence. This is hard because of a lack of understanding of our own intelligence. Computers are superhuman at chess, and now even a more complex game like Go. The braver predictors who came up with timelines thought AlphaGo’s success was faster than expected, but does this necessarily mean we’re closer to general intelligence than they thought?
Here is where it’s harder to track progress.
We can note the specialized performance of algorithms on tasks previously reserved for humans—for example, the index cites a Nature paper that shows AI can now predict skin cancer with more accuracy than dermatologists. We could even try to track one specific approach to general AI; for example, how many regions of the brain have been successfully simulated by a computer? Alternatively, we could simply keep track of the number of professions and professional tasks that can now be performed to an acceptable standard by AI.

“We are running a race, but we don’t know how to get to the endpoint, or how far we have to go.”

Progress in AI over the next few years is far more likely to resemble a gradual rising tide—as more and more tasks can be turned into algorithms and accomplished by software—rather than the tsunami of a sudden intelligence explosion or general intelligence breakthrough. Perhaps measuring the ability of an AI system to learn and adapt to the work routines of humans in office-based tasks could be possible.
The AI index doesn’t attempt to offer a timeline for general intelligence, as this is still too nebulous and confused a concept.
Michael Woodridge, head of Computer Science at the University of Oxford, notes, “The main reason general AI is not captured in the report is that neither I nor anyone else would know how to measure progress.” He is concerned about another AI winter, and overhyped “charlatans and snake-oil salesmen” exaggerating the progress that has been made.
A key concern that all the experts bring up is the ethics of artificial intelligence.
Of course, you don’t need general intelligence to have an impact on society; algorithms are already transforming our lives and the world around us. After all, why are Amazon, Google, and Facebook worth any money? The experts agree on the need for an index to measure the benefits of AI, the interactions between humans and AIs, and our ability to program values, ethics, and oversight into these systems.
Barbra Grosz of Harvard champions this view, saying, “It is important to take on the challenge of identifying success measures for AI systems by their impact on people’s lives.”
For those concerned about the AI employment apocalypse, tracking the use of AI in the fields considered most vulnerable (say, self-driving cars replacing taxi drivers) would be a good idea. Society’s flexibility for adapting to AI trends should be measured, too; are we providing people with enough educational opportunities to retrain? How about teaching them to work alongside the algorithms, treating them as tools rather than replacements? The experts also note that the data suffers from being US-centric.
We are running a race, but we don’t know how to get to the endpoint, or how far we have to go. We are judging by the scenery, and how far we’ve run already. For this reason, measuring progress is a daunting task that starts with defining progress. But the AI index, as an annual collection of relevant information, is a good start.
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Posted in Human Robots

#431925 How the Science of Decision-Making Will ...

Posted on January 18, 2018 by Android

Neuroscientist Brie Linkenhoker believes that leaders must be better prepared for future strategic challenges by continually broadening their worldviews.
As the director of Worldview Stanford, Brie and her team produce multimedia content and immersive learning experiences to make academic research and insights accessible and useable by curious leaders. These future-focused topics are designed to help curious leaders understand the forces shaping the future.
Worldview Stanford has tackled such interdisciplinary topics as the power of minds, the science of decision-making, environmental risk and resilience, and trust and power in the age of big data.
We spoke with Brie about why understanding our biases is critical to making better decisions, particularly in a time of increasing change and complexity.

Lisa Kay Solomon: What is Worldview Stanford?
Brie Linkenhoker: Leaders and decision makers are trying to navigate this complex hairball of a planet that we live on and that requires keeping up on a lot of diverse topics across multiple fields of study and research. Universities like Stanford are where that new knowledge is being created, but it’s not getting out and used as readily as we would like, so that’s what we’re working on.
Worldview is designed to expand our individual and collective worldviews about important topics impacting our future. Your worldview is not a static thing, it’s constantly changing. We believe it should be informed by lots of different perspectives, different cultures, by knowledge from different domains and disciplines. This is more important now than ever.
At Worldview, we create learning experiences that are an amalgamation of all of those things.
LKS: One of your marquee programs is the Science of Decision Making. Can you tell us about that course and why it’s important?
BL: We tend to think about decision makers as being people in leadership positions, but every person who works in your organization, every member of your family, every member of the community is a decision maker. You have to decide what to buy, who to partner with, what government regulations to anticipate.
You have to think not just about your own decisions, but you have to anticipate how other people make decisions too. So, when we set out to create the Science of Decision Making, we wanted to help people improve their own decisions and be better able to predict, understand, anticipate the decisions of others.

“I think in another 10 or 15 years, we’re probably going to have really rich models of how we actually make decisions and what’s going on in the brain to support them.”

We realized that the only way to do that was to combine a lot of different perspectives, so we recruited experts from economics, psychology, neuroscience, philosophy, biology, and religion. We also brought in cutting-edge research on artificial intelligence and virtual reality and explored conversations about how technology is changing how we make decisions today and how it might support our decision-making in the future.
There’s no single set of answers. There are as many unanswered questions as there are answered questions.
LKS: One of the other things you explore in this course is the role of biases and heuristics. Can you explain the importance of both in decision-making?
BL: When I was a strategy consultant, executives would ask me, “How do I get rid of the biases in my decision-making or my organization’s decision-making?” And my response would be, “Good luck with that. It isn’t going to happen.”
As human beings we make, probably, thousands of decisions every single day. If we had to be actively thinking about each one of those decisions, we wouldn’t get out of our house in the morning, right?
We have to be able to do a lot of our decision-making essentially on autopilot to free up cognitive resources for more difficult decisions. So, we’ve evolved in the human brain a set of what we understand to be heuristics or rules of thumb.
And heuristics are great in, say, 95 percent of situations. It’s that five percent, or maybe even one percent, that they’re really not so great. That’s when we have to become aware of them because in some situations they can become biases.
For example, it doesn’t matter so much that we’re not aware of our rules of thumb when we’re driving to work or deciding what to make for dinner. But they can become absolutely critical in situations where a member of law enforcement is making an arrest or where you’re making a decision about a strategic investment or even when you’re deciding who to hire.
Let’s take hiring for a moment.
How many years is a hire going to impact your organization? You’re potentially looking at 5, 10, 15, 20 years. Having the right person in a role could change the future of your business entirely. That’s one of those areas where you really need to be aware of your own heuristics and biases—and we all have them. There’s no getting rid of them.
LKS: We seem to be at a time when the boundaries between different disciplines are starting to blend together. How has the advancement of neuroscience help us become better leaders? What do you see happening next?
BL: Heuristics and biases are very topical these days, thanks in part to Michael Lewis’s fantastic book, The Undoing Project, which is the story of the groundbreaking work that Nobel Prize winner Danny Kahneman and Amos Tversky did in the psychology and biases of human decision-making. Their work gave rise to the whole new field of behavioral economics.
In the last 10 to 15 years, neuroeconomics has really taken off. Neuroeconomics is the combination of behavioral economics with neuroscience. In behavioral economics, they use economic games and economic choices that have numbers associated with them and have real-world application.
For example, they ask, “How much would you spend to buy A versus B?” Or, “If I offered you X dollars for this thing that you have, would you take it or would you say no?” So, it’s trying to look at human decision-making in a format that’s easy to understand and quantify within a laboratory setting.
Now you bring neuroscience into that. You can have people doing those same kinds of tasks—making those kinds of semi-real-world decisions—in a brain scanner, and we can now start to understand what’s going on in the brain while people are making decisions. You can ask questions like, “Can I look at the signals in someone’s brain and predict what decision they’re going to make?” That can help us build a model of decision-making.
I think in another 10 or 15 years, we’re probably going to have really rich models of how we actually make decisions and what’s going on in the brain to support them. That’s very exciting for a neuroscientist.
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Posted in Human Robots