Tag Archives: tests

#435757 Robotic Animal Agility

Posted on September 19, 2019 by Android

An off-shore wind power platform, somewhere in the North Sea, on a freezing cold night, with howling winds and waves crashing against the impressive structure. An imperturbable ANYmal is quietly conducting its inspection.

ANYmal, a medium sized dog-like quadruped robot, walks down the stairs, lifts a “paw” to open doors or to call the elevator and trots along corridors. Darkness is no problem: it knows the place perfectly, having 3D-mapped it. Its laser sensors keep it informed about its precise path, location and potential obstacles. It conducts its inspection across several rooms. Its cameras zoom in on counters, recording the measurements displayed. Its thermal sensors record the temperature of machines and equipment and its ultrasound microphone checks for potential gas leaks. The robot also inspects lever positions as well as the correct positioning of regulatory fire extinguishers. As the electronic buzz of its engines resumes, it carries on working tirelessly.

After a little over two hours of inspection, the robot returns to its docking station for recharging. It will soon head back out to conduct its next solitary patrol. ANYmal played alongside Mulder and Scully in the “X-Files” TV series*, but it is in no way a Hollywood robot. It genuinely exists and surveillance missions are part of its very near future.

Off-shore oil platforms, the first test fields and probably the first actual application of ANYmal. ©ANYbotics

This quadruped robot was designed by ANYbotics, a spinoff of the Swiss Federal Institute of Technology in Zurich (ETH Zurich). Made of carbon fibre and aluminium, it weighs about thirty kilos. It is fully ruggedised, water- and dust-proof (IP-67). A kevlar belly protects its main body, carrying its powerful brain, batteries, network device, power management system and navigational systems.

ANYmal was designed for all types of terrain, including rubble, sand or snow. It has been field tested on industrial sites and is at ease with new obstacles to overcome (and it can even get up after a fall). Depending on its mission, its batteries last 2 to 4 hours.

On its jointed legs, protected by rubber pads, it can walk (at the speed of human steps), trot, climb, curl upon itself to crawl, carry a load or even jump and dance. It is the need to move on all surfaces that has driven its designers to choose a quadruped. “Biped robots are not easy to stabilise, especially on irregular terrain” explains Dr Péter Fankhauser, co-founder and chief business development officer of ANYbotics. “Wheeled or tracked robots can carry heavy loads, but they are bulky and less agile. Flying drones are highly mobile, but cannot carry load, handle objects or operate in bad weather conditions. We believe that quadrupeds combine the optimal characteristics, both in terms of mobility and versatility.”

What served as a source of inspiration for the team behind the project, the Robotic Systems Lab of the ETH Zurich, is a champion of agility on rugged terrain: the mountain goat. “We are of course still a long way” says Fankhauser. “However, it remains our objective on the longer term.

The first prototype, ALoF, was designed already back in 2009. It was still rather slow, very rigid and clumsy – more of a proof of concept than a robot ready for application. In 2012, StarlETH, fitted with spring joints, could hop, jump and climb. It was with this robot that the team started participating in 2014 in ARGOS, a full-scale challenge, launched by the Total oil group. The idea was to present a robot capable of inspecting an off-shore drilling station autonomously.

Up against dozens of competitors, the ETH Zurich team was the only team to enter the competition with such a quadrupedal robot. They didn’t win, but the multiple field tests were growing evermore convincing. Especially because, during the challenge, the team designed new joints with elastic actuators made in-house. These joints, inspired by tendons and muscles, are compact, sealed and include their own custom control electronics. They can regulate joint torque, position and impedance directly. Thanks to this innovation, the team could enter the same competition with a new version of its robot, ANYmal, fitted with three joints on each leg.

The ARGOS experience confirms the relevance of the selected means of locomotion. “Our robot is lighter, takes up less space on site and it is less noisy” says Fankhauser. “It also overcomes bigger obstacles than larger wheeled or tracked robots!” As ANYmal generated public interest and its transformation into a genuine product seemed more than possible, the startup ANYbotics was launched in 2016. It sold not only its robot, but also its revolutionary joints, called ANYdrive.

Today, ANYmal is not yet ready for sale to companies. However, ANYbotics has a growing number of partnerships with several industries, testing the robot for a few days or several weeks, for all types of tasks. Last October, for example, ANYmal navigated its way through the dark sewage system of the city of Zurich in order to test its capacity to help workers in similar difficult, repetitive and even dangerous tasks.

Why such an early interest among companies? “Because many companies want to integrate robots into their maintenance tasks” answers Fankhauser. “With ANYmal, they can actually evaluate its feasibility and plan their strategy. Eventually, both the architecture and the equipment of buildings could be rethought to be adapted to these maintenance robots”.

ANYmal requires ruggedised, sealed and extremely reliable interconnection solutions, such as LEMO. ©ANYbotics

Through field demonstrations and testing, ANYbotics can gather masses of information (up to 50,000 measurements are recorded every second during each test!) “It helps us to shape the product.” In due time, the startup will be ready to deliver a commercial product which really caters for companies’ needs.

Inspection and surveillance tasks on industrial sites are not the only applications considered. The startup is also thinking of agricultural inspections – with its onboard sensors, ANYmal is capable of mapping its environment, measuring bio mass and even taking soil samples. In the longer term, it could also be used for search and rescue operations. By the way, the robot can already be switched to “remote control” mode at any time and can be easily tele-operated. It is also capable of live audio and video transmission.

The transition from the prototype to the marketed product stage will involve a number of further developments. These include increasing ANYmal’s agility and speed, extending its capacity to map large-scale environments, improving safety, security, user handling and integrating the system with the customer’s data management software. It will also be necessary to enhance the robot’s reliability “so that it can work for days, weeks, or even months without human supervision.” All required certifications will have to be obtained. The locomotion system, which had triggered the whole business, is only one of a number of considerations of ANYbotics.

Designed for extreme environments, for ANYmal smoke is not a problem and it can walk in the snow, through rubble or in water. ©ANYbotics

The startup is not all alone. In fact, it has sold ANYmal robots to a dozen major universities who use them to develop their know-how in robotics. The startup has also founded ANYmal Research, a community including members such as Toyota Research Institute, the German Aerospace Center and the computer company Nvidia. Members have full access to ANYmal’s control software, simulations and documentation. Sharing has boosted both software and hardware ideas and developments (built on ROS, the open-source Robot Operating System). In particular, payload variations, providing for expandability and scalability. For instance, one of the universities uses a robotic arm which enables ANYmal to grasp or handle objects and open doors.

Among possible applications, ANYbotics mentions entertainment. It is not only about playing in more films or TV series, but rather about participating in various attractions (trade shows, museums, etc.). “ANYmal is so novel that it attracts a great amount of interest” confirms Fankhauser with a smile. “Whenever we present it somewhere, people gather around.”

Videos of these events show a fascinated and sometimes slightly fearful audience, when ANYmal gets too close to them. Is it fear of the “bad robot”? “This fear exists indeed and we are happy to be able to use ANYmal also to promote public awareness towards robotics and robots.” Reminiscent of a young dog, ANYmal is truly adapted for the purpose.

However, Péter Fankhauser softens the image of humans and sophisticated robots living together. “These coming years, robots will continue to work in the background, like they have for a long time in factories. Then, they will be used in public places in a selective and targeted way, for instance for dangerous missions. We will need to wait another ten years before animal-like robots, such as ANYmal will share our everyday lives!”

At the Consumer Electronics Show (CES) in Las Vegas in January, Continental, the German automotive manufacturing company, used robots to demonstrate a last-mile delivery. It showed ANYmal getting out of an autonomous vehicle with a parcel, climbing onto the front porch, lifting a paw to ring the doorbell, depositing the parcel before getting back into the vehicle. This futuristic image seems very close indeed.

*X-Files, season 11, episode 7, aired in February 2018 Continue reading →

Posted in Human Robots

#435738 Boing Goes the Trampoline Robot

Posted on September 18, 2019 by Android

There are a handful of quadrupedal robots out there that are highly dynamic, with the ability to run and jump, but those robots tend to be rather expensive and complicated, requiring powerful actuators and legs with elasticity. Boxing Wang, a Ph.D. student in the College of Control Science and Engineering at Zhejiang University in China, contacted us to share a project he’s been working to investigate quadruped jumping with simple, affordable hardware.

“The motivation for this project is quite simple,” Boxing says. “I wanted to study quadrupedal jumping control, but I didn’t have custom-made powerful actuators, and I didn’t want to have to design elastic legs. So I decided to use a trampoline to make a normal servo-driven quadruped robot to jump.”

Boxing and his colleagues had wanted to study quadrupedal running and jumping, so they built this robot with the most powerful servos they had access to: Kondo KRS6003RHV actuators, which have a maximum torque of 6 Nm. After some simple testing, it became clear that the servos were simply not fast or powerful enough to get the robot to jump, and that an elastic element was necessary to store energy to help the robot get off the ground.

“Normally, people would choose elastic legs,” says Boxing. “But nobody in my lab knew for sure how to design them. If we tried making elastic legs and we failed to make the robot jump, we couldn’t be sure whether the problem was the legs or the control algorithms. For hardware, we decided that it’s better to start with something reliable, something that definitely won’t be the source of the problem.”

As it turns out, all you need is a trampoline, an inertial measurement unit (IMU), and little tactile switches on the end of each foot to detect touch-down and lift-off events, and you can do some useful jumping research without a jumping robot. And the trampoline has other benefits as well—because it’s stiffer at the edges than at the center, for example, the robot will tend to center itself on the trampoline, and you get some warning before things go wrong.

“I can’t say that it’s a breakthrough to make a quadruped robot jump on a trampoline,” Boxing tells us. “But I believe this is useful for prototype testing, especially for people who are interested in quadrupedal jumping control but without a suitable robot at hand.”

To learn more about the project, we emailed him some additional questions.

IEEE Spectrum: Where did this idea come from?

Boxing Wang: The idea of the trampoline came while we were drinking milk tea. I don’t know why it came up, maybe someone saw a trampoline in a gym recently. And I don’t remember who proposed it exactly. It was just like someone said it unintentionally. But I realized that a trampoline would be a perfect choice. It’s reliable, easy to buy, and should have a similar dynamic model with the one of jumping with springy legs (we have briefly analyzed this in a paper). So I decided to try the trampoline.

How much do you think you can learn using a quadruped on a trampoline, instead of using a jumping quadruped?

Generally speaking, no contact surfaces are strictly rigid. They all have elasticity. So there are no essential differences between jumping on a trampoline and jumping on a rigid surface. However, using a quadruped on a trampoline can give you more information on how to make use of elasticity to make jumping easier and more efficient. You can use quadruped robots with springy legs to address the same problem, but that usually requires much more time on hardware design.

We prefer to treat the trampoline experiment as a kind of early test for further real jumping quadruped design. Unless you’re interested in designing an acrobatic robot on a trampoline, a real jumping quadruped is probably a more useful application, and that is our ultimate goal. The point of the trampoline tests is to develop the control algorithms first, and to examine the stability of the general hardware structure. Due to the similarity between jumping on a trampoline with rigid legs and jumping on hard surfaces with springy legs, the control algorithms you develop could be transferred to hard-surface jumping robots.

“Unless you’re interested in designing an acrobatic robot on a trampoline, a real jumping quadruped is probably a more useful application, and that is our ultimate goal. The point of the trampoline tests is to develop the control algorithms first, and to examine the stability of the general hardware structure”

Do you think that this idea can be beneficial for other kinds of robotics research?

Yes. For jumping quadrupeds with springy legs, the control algorithms could be first designed through trampoline tests using simple rigid legs. And the hardware design for elastic legs could be accelerated with the help of the control algorithms you design. In addition, we believe our work could be a good example of using a position-control robot to realize dynamic motions such as jumping, or even running.

Unlike other dynamic robots, every active joint in our robot is controlled through commercial position-control servos and not custom torque control motors. Most people don’t think that a position-control robot could perform highly dynamic motions such as jumping, because position-control motors usually mean high a gear ratio and slow response. However, our work indicates that, with the help of elasticity, stable jumping could be realized through position-control servos. So for those who already have a position-control robot at hand, they could explore the potential of their robot through trampoline tests.

Why is teaching a robot to jump important?

There are many scenarios where a jumping robot is needed. For example, a real jumping quadruped could be used to design a running quadruped. Both experience moments when all four legs are in the air, and it is easier to start from jumping and then move to running. Specifically, hopping or pronking can easily transform to bounding if the pitch angle is not strictly controlled. A bounding quadruped is similar to a running rabbit, so for now it can already be called a running quadruped.

To the best of our knowledge, a practical use of jumping quadrupeds could be planet exploration, just like what SpaceBok was designed for. In a low-gravity environment, jumping is more efficient than walking, and it’s easier to jump over obstacles. But if I had a jumping quadruped on Earth, I would teach it to catch a ball that I throw at it by jumping. It would be fantastic!

That would be fantastic.

Since the whole point of the trampoline was to get jumping software up and running with a minimum of hardware, the next step is to add some springy legs to the robot so that the control system the researchers developed can be tested on hard surfaces. They have a journal paper currently under revision, and Boxing Wang is joined as first author by his adviser Chunlin Zhou, undergrads Ziheng Duan and Qichao Zhu, and researchers Jun Wu and Rong Xiong. Continue reading →

Posted in Human Robots

#435621 ANYbotics Introduces Sleek New ANYmal C ...

Posted on September 13, 2019 by Android

Quadrupedal robots are making significant advances lately, and just in the past few months we’ve seen Boston Dynamics’ Spot hauling a truck, IIT’s HyQReal pulling a plane, MIT’s MiniCheetah doing backflips, Unitree Robotics’ Laikago towing a van, and Ghost Robotics’ Vision 60 exploring a mine. Robot makers are betting that their four-legged machines will prove useful in a variety of applications in construction, security, delivery, and even at home.

ANYbotics has been working on such applications for years, testing out their ANYmal robot in places where humans typically don’t want to go (like offshore platforms) as well as places where humans really don’t want to go (like sewers), and they have a better idea than most companies what can make quadruped robots successful.

This week, ANYbotics is announcing a completely new quadruped platform, ANYmal C, a major upgrade from the really quite research-y ANYmal B. The new quadruped has been optimized for ruggedness and reliability in industrial environments, with a streamlined body painted a color that lets you know it means business.

ANYmal C’s physical specs are pretty impressive for a production quadruped. It can move at 1 meter per second, manage 20-degree slopes and 45-degree stairs, cross 25-centimeter gaps, and squeeze through passages just 60 centimeters wide. It’s packed with cameras and 3D sensors, including a lidar for 3D mapping and simultaneous localization and mapping (SLAM). All these sensors (along with the vast volume of gait research that’s been done with ANYmal) make this one of the most reliably autonomous quadrupeds out there, with real-time motion planning and obstacle avoidance.

Image: ANYbotics

ANYmal can autonomously attach itself to a cone-shaped docking station to recharge.

ANYmal C is also one of the ruggedest legged robots in existence. The 50-kilogram robot is IP67 rated, meaning that it’s completely impervious to dust and can withstand being submerged in a meter of water for an hour. If it’s submerged for longer than that, you’re absolutely doing something wrong. The robot will run for over 2 hours on battery power, and if that’s not enough endurance, don’t worry, because ANYmal can autonomously impale itself on a weird cone-shaped docking station to recharge.

Photo: ANYbotics

ANYmal C’s sensor payload includes cameras and a lidar for 3D mapping and SLAM.

As far as what ANYmal C is designed to actually do, it’s mostly remote inspection tasks where you need to move around through a relatively complex environment, but where for whatever reason you’d be better off not sending a human. ANYmal C has a sensor payload that gives it lots of visual options, like thermal imaging, and with the ability to handle a 10-kilogram payload, the robot can be adapted to many different environments.

Over the next few months, we’re hoping to see more examples of ANYmal C being deployed to do useful stuff in real-world environments, but for now, we do have a bit more detail from ANYbotics CTO Christian Gehring.

IEEE Spectrum: Can you tell us about the development process for ANYmal C?

Christian Gehring: We tested the previous generation of ANYmal (B) in a broad range of environments over the last few years and gained a lot of insights. Based on our learnings, it became clear that we would have to re-design the robot to meet the requirements of industrial customers in terms of safety, quality, reliability, and lifetime. There were different prototype stages both for the new drives and for single robot assemblies. Apart from electrical tests, we thoroughly tested the thermal control and ingress protection of various subsystems like the depth cameras and actuators.

What can ANYmal C do that the previous version of ANYmal can’t?

ANYmal C was redesigned with a focus on performance increase regarding actuation (new drives), computational power (new hexacore Intel i7 PCs), locomotion and navigation skills, and autonomy (new depth cameras). The new robot additionally features a docking system for autonomous recharging and an inspection payload as an option. The design of ANYmal C is far more integrated than its predecessor, which increases both performance and reliability.

How much of ANYmal C’s development and design was driven by your experience with commercial or industry customers?

Tests (such as the offshore installation with TenneT) and discussions with industry customers were important to get the necessary design input in terms of performance, safety, quality, reliability, and lifetime. Most customers ask for very similar inspection tasks that can be performed with our standard inspection payload and the required software packages. Some are looking for a robot that can also solve some simple manipulation tasks like pushing a button. Overall, most use cases customers have in mind are realistic and achievable, but some are really tough for the robot, like climbing 50° stairs in hot environments of 50°C.

Can you describe how much autonomy you expect ANYmal C to have in industrial or commercial operations?

ANYmal C is primarily developed to perform autonomous routine inspections in industrial environments. This autonomy especially adds value for operations that are difficult to access, as human operation is extremely costly. The robot can naturally also be operated via a remote control and we are working on long-distance remote operation as well.

Do you expect that researchers will be interested in ANYmal C? What research applications could it be useful for?

ANYmal C has been designed to also address the needs of the research community. The robot comes with two powerful hexacore Intel i7 computers and can additionally be equipped with an NVIDIA Jetson Xavier graphics card for learning-based applications. Payload interfaces enable users to easily install and test new sensors. By joining our established ANYmal Research community, researchers get access to simulation tools and software APIs, which boosts their research in various areas like control, machine learning, and navigation.

[ ANYmal C ] Continue reading →

Posted in Human Robots

#435591 Video Friday: This Robotic Thread Could ...

Posted on September 11, 2019 by Android

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

IEEE Africon 2019 – September 25-27, 2019 – Accra, Ghana
ISRR 2019 – October 6-10, 2019 – Hanoi, Vietnam
Ro-Man 2019 – October 14-18, 2019 – New Delhi, India
Humanoids 2019 – October 15-17, 2019 – Toronto, Canada
ARSO 2019 – October 31-1, 2019 – Beijing, China
ROSCon 2019 – October 31-1, 2019 – Macau
IROS 2019 – November 4-8, 2019 – Macau
Let us know if you have suggestions for next week, and enjoy today’s videos.

Eight engineering students from ETH Zurich are working on a year-long focus project to develop a multimodal robot called Dipper, which can fly, swim, dive underwater, and manage that difficult air-water transition:

The robot uses one motor to selectively drive either a propeller or a marine screw depending on whether it’s in flight or not. We’re told that getting the robot to autonomously do the water to air transition is still a work in progress, but that within a few weeks things should be much smoother.

[ Dipper ]

Thanks Simon!

Giving a jellyfish a hug without stressing them out is exactly as hard as you think, but Harvard’s robot will make sure that all jellyfish get the emotional (and physical) support that they need.

The gripper’s six “fingers” are composed of thin, flat strips of silicone with a hollow channel inside bonded to a layer of flexible but stiffer polymer nanofibers. The fingers are attached to a rectangular, 3D-printed plastic “palm” and, when their channels are filled with water, curl in the direction of the nanofiber-coated side. Each finger exerts an extremely low amount of pressure — about 0.0455 kPA, or less than one-tenth of the pressure of a human’s eyelid on their eye. By contrast, current state-of-the-art soft marine grippers, which are used to capture delicate but more robust animals than jellyfish, exert about 1 kPA.

The gripper was successfully able to trap each jellyfish against the palm of the device, and the jellyfish were unable to break free from the fingers’ grasp until the gripper was depressurized. The jellyfish showed no signs of stress or other adverse effects after being released, and the fingers were able to open and close roughly 100 times before showing signs of wear and tear.

[ Harvard ]

MIT engineers have developed a magnetically steerable, thread-like robot that can actively glide through narrow, winding pathways, such as the labyrinthine vasculature of the brain. In the future, this robotic thread may be paired with existing endovascular technologies, enabling doctors to remotely guide the robot through a patient’s brain vessels to quickly treat blockages and lesions, such as those that occur in aneurysms and stroke.

[ MIT ]

See NASA’s next Mars rover quite literally coming together inside a clean room at the Jet Propulsion Laboratory. This behind-the-scenes look at what goes into building and preparing a rover for Mars, including extensive tests in simulated space environments, was captured from March to July 2019. The rover is expected to launch to the Red Planet in summer 2020 and touch down in February 2021.

The Mars 2020 rover doesn’t have a name yet, but you can give it one! As long as you’re not too old! Which you probably are!

[ Mars 2020 ]

I desperately wish that we could watch this next video at normal speed, not just slowed down, but it’s quite impressive anyway.

Here’s one more video from the Namiki Lab showing some high speed tracking with a pair of very enthusiastic robotic cameras:

[ Namiki Lab ]

Normally, tedious modeling of mechanics, electronics, and information science is required to understand how insects’ or robots’ moving parts coordinate smoothly to take them places. But in a new study, biomechanics researchers at the Georgia Institute of Technology boiled down the sprints of cockroaches to handy principles and equations they then used to make a test robot amble about better.

[ Georgia Tech ]

More magical obstacle-dodging footage from Skydio’s still secret new drone.

We’ve been hard at work extending the capabilities of our upcoming drone, giving you ways to get the control you want without the stress of crashing. The result is you can fly in ways, and get shots, that would simply be impossible any other way. How about flying through obstacles at full speed, backwards?

[ Skydio ]

This is a cute demo with Misty:

[ Misty Robotics ]

We’ve seen pieces of hardware like this before, but always made out of hard materials—a soft version is certainly something new.

Utilizing vacuum power and soft material actuators, we have developed a soft reconfigurable surface (SRS) with multi-modal control and performance capabilities. The SRS is comprised of a square grid array of linear vacuum-powered soft pneumatic actuators (linear V-SPAs), built into plug-and-play modules which enable the arrangement, consolidation, and control of many DoF.

[ RRL ]

The EksoVest is not really a robot, but it’ll make you a cyborg! With super strength!

“This is NOT intended to give you super strength but instead give you super endurance and reduce fatigue so that you have more energy and less soreness at the end of your shift.”

Drat!

[ EksoVest ]

We have created a solution for parents, grandparents, and their children who are living separated. This is an amazing tool to stay connected from a distance through the intimacy that comes through interactive play with a child. For parents who travel for work, deployed military, and families spread across the country, the Cushybot One is much more than a toy; it is the opportunity for maintaining a deep connection with your young child from a distance.

Hmm.

I think the concept here is great, but it’s going to be a serious challenge to successfully commercialize.

[ Indiegogo ]

What happens when you equip RVR with a parachute and send it off a cliff? Watch this episode of RVR Launchpad to find out – then go Behind the Build to see how we (eventually) accomplished this high-flying feat.

[ Sphero ]

These omnidirectional crawler robots aren’t new, but that doesn’t keep them from being fun to watch.

[ NEDO ] via [ Impress ]

We’ll finish up the week with a couple of past ICRA and IROS keynote talks—one by Gill Pratt on The Reliability Challenges of Autonomous Driving, and the other from Peter Hart, on Making Shakey.

[ IEEE RAS ] Continue reading →

Posted in Human Robots

#435575 How an AI Startup Designed a Drug ...

Posted on September 9, 2019 by Android

Discovering a new drug can take decades, billions of dollars, and untold man hours from some of the smartest people on the planet. Now a startup says it’s taken a significant step towards speeding the process up using AI.

The typical drug discovery process involves carrying out physical tests on enormous libraries of molecules, and even with the help of robotics it’s an arduous process. The idea of sidestepping this by using computers to virtually screen for promising candidates has been around for decades. But progress has been underwhelming, and it’s still not a major part of commercial pipelines.

Recent advances in deep learning, however, have reignited hopes for the field, and major pharma companies have started tying up with AI-powered drug discovery startups. And now Insilico Medicine has used AI to design a molecule that effectively targets a protein involved in fibrosis—the formation of excess fibrous tissue—in mice in just 46 days.

The platform the company has developed combines two of the hottest sub-fields of AI: the generative adversarial networks, or GANs, which power deepfakes, and reinforcement learning, which is at the heart of the most impressive game-playing AI advances of recent years.

In a paper in Nature Biotechnology, the company’s researchers describe how they trained their model on all the molecules already known to target this protein as well as many other active molecules from various datasets. The model was then used to generate 30,000 candidate molecules.

Unlike most previous efforts, they went a step further and selected the most promising molecules for testing in the lab. The 30,000 candidates were whittled down to just 6 using more conventional drug discovery approaches and were then synthesized in the lab. They were put through increasingly stringent tests, but the leading candidate was found to be effective at targeting the desired protein and behaved as one would hope a drug would.

The authors are clear that the results are just a proof-of-concept, which company CEO Alex Zhavoronkov told Wired stemmed from a challenge set by a pharma partner to design a drug as quickly as possible. But they say they were able to carry out the process faster than traditional methods for a fraction of the cost.

There are some caveats. For a start, the protein being targeted is already very well known and multiple effective drugs exist for it. That gave the company a wealth of data to train their model on, something that isn’t the case for many of the diseases where we urgently need new drugs.

The company’s platform also only targets the very initial stages of the drug discovery process. The authors concede in their paper that the molecules would still take considerable optimization in the lab before they’d be true contenders for clinical trials.

“And that is where you will start to begin to commence to spend the vast piles of money that you will eventually go through in trying to get a drug to market,” writes Derek Lowe in his blog In The Pipeline. The part of the discovery process that the platform tackles represents a tiny fraction of the total cost of drug development, he says.

Nonetheless, the research is a definite advance for virtual screening technology and an important marker of the potential of AI for designing new medicines. Zhavoronkov also told Wired that this research was done more than a year ago, and they’ve since adapted the platform to go after harder drug targets with less data.

And with big pharma companies desperate to slash their ballooning development costs and find treatments for a host of intractable diseases, they can use all the help they can get.

Image Credit: freestocks.org / Unsplash Continue reading →

Posted in Human Robots