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#435738 Boing Goes the Trampoline Robot

Posted on September 18, 2019 by Android

There are a handful of quadrupedal robots out there that are highly dynamic, with the ability to run and jump, but those robots tend to be rather expensive and complicated, requiring powerful actuators and legs with elasticity. Boxing Wang, a Ph.D. student in the College of Control Science and Engineering at Zhejiang University in China, contacted us to share a project he’s been working to investigate quadruped jumping with simple, affordable hardware.

“The motivation for this project is quite simple,” Boxing says. “I wanted to study quadrupedal jumping control, but I didn’t have custom-made powerful actuators, and I didn’t want to have to design elastic legs. So I decided to use a trampoline to make a normal servo-driven quadruped robot to jump.”

Boxing and his colleagues had wanted to study quadrupedal running and jumping, so they built this robot with the most powerful servos they had access to: Kondo KRS6003RHV actuators, which have a maximum torque of 6 Nm. After some simple testing, it became clear that the servos were simply not fast or powerful enough to get the robot to jump, and that an elastic element was necessary to store energy to help the robot get off the ground.

“Normally, people would choose elastic legs,” says Boxing. “But nobody in my lab knew for sure how to design them. If we tried making elastic legs and we failed to make the robot jump, we couldn’t be sure whether the problem was the legs or the control algorithms. For hardware, we decided that it’s better to start with something reliable, something that definitely won’t be the source of the problem.”

As it turns out, all you need is a trampoline, an inertial measurement unit (IMU), and little tactile switches on the end of each foot to detect touch-down and lift-off events, and you can do some useful jumping research without a jumping robot. And the trampoline has other benefits as well—because it’s stiffer at the edges than at the center, for example, the robot will tend to center itself on the trampoline, and you get some warning before things go wrong.

“I can’t say that it’s a breakthrough to make a quadruped robot jump on a trampoline,” Boxing tells us. “But I believe this is useful for prototype testing, especially for people who are interested in quadrupedal jumping control but without a suitable robot at hand.”

To learn more about the project, we emailed him some additional questions.

IEEE Spectrum: Where did this idea come from?

Boxing Wang: The idea of the trampoline came while we were drinking milk tea. I don’t know why it came up, maybe someone saw a trampoline in a gym recently. And I don’t remember who proposed it exactly. It was just like someone said it unintentionally. But I realized that a trampoline would be a perfect choice. It’s reliable, easy to buy, and should have a similar dynamic model with the one of jumping with springy legs (we have briefly analyzed this in a paper). So I decided to try the trampoline.

How much do you think you can learn using a quadruped on a trampoline, instead of using a jumping quadruped?

Generally speaking, no contact surfaces are strictly rigid. They all have elasticity. So there are no essential differences between jumping on a trampoline and jumping on a rigid surface. However, using a quadruped on a trampoline can give you more information on how to make use of elasticity to make jumping easier and more efficient. You can use quadruped robots with springy legs to address the same problem, but that usually requires much more time on hardware design.

We prefer to treat the trampoline experiment as a kind of early test for further real jumping quadruped design. Unless you’re interested in designing an acrobatic robot on a trampoline, a real jumping quadruped is probably a more useful application, and that is our ultimate goal. The point of the trampoline tests is to develop the control algorithms first, and to examine the stability of the general hardware structure. Due to the similarity between jumping on a trampoline with rigid legs and jumping on hard surfaces with springy legs, the control algorithms you develop could be transferred to hard-surface jumping robots.

“Unless you’re interested in designing an acrobatic robot on a trampoline, a real jumping quadruped is probably a more useful application, and that is our ultimate goal. The point of the trampoline tests is to develop the control algorithms first, and to examine the stability of the general hardware structure”

Do you think that this idea can be beneficial for other kinds of robotics research?

Yes. For jumping quadrupeds with springy legs, the control algorithms could be first designed through trampoline tests using simple rigid legs. And the hardware design for elastic legs could be accelerated with the help of the control algorithms you design. In addition, we believe our work could be a good example of using a position-control robot to realize dynamic motions such as jumping, or even running.

Unlike other dynamic robots, every active joint in our robot is controlled through commercial position-control servos and not custom torque control motors. Most people don’t think that a position-control robot could perform highly dynamic motions such as jumping, because position-control motors usually mean high a gear ratio and slow response. However, our work indicates that, with the help of elasticity, stable jumping could be realized through position-control servos. So for those who already have a position-control robot at hand, they could explore the potential of their robot through trampoline tests.

Why is teaching a robot to jump important?

There are many scenarios where a jumping robot is needed. For example, a real jumping quadruped could be used to design a running quadruped. Both experience moments when all four legs are in the air, and it is easier to start from jumping and then move to running. Specifically, hopping or pronking can easily transform to bounding if the pitch angle is not strictly controlled. A bounding quadruped is similar to a running rabbit, so for now it can already be called a running quadruped.

To the best of our knowledge, a practical use of jumping quadrupeds could be planet exploration, just like what SpaceBok was designed for. In a low-gravity environment, jumping is more efficient than walking, and it’s easier to jump over obstacles. But if I had a jumping quadruped on Earth, I would teach it to catch a ball that I throw at it by jumping. It would be fantastic!

That would be fantastic.

Since the whole point of the trampoline was to get jumping software up and running with a minimum of hardware, the next step is to add some springy legs to the robot so that the control system the researchers developed can be tested on hard surfaces. They have a journal paper currently under revision, and Boxing Wang is joined as first author by his adviser Chunlin Zhou, undergrads Ziheng Duan and Qichao Zhu, and researchers Jun Wu and Rong Xiong. Continue reading →

Posted in Human Robots

#435722 Stochastic Robots Use Randomness to ...

Posted on September 18, 2019 by Android

The idea behind swarm robots is to replace discrete, expensive, breakable uni-tasking components with a whole bunch of much simpler, cheaper, and replaceable robots that can work together to do the same sorts of tasks. Unfortunately, all of those swarm robots end up needing their own computing and communications and stuff if you want to get them to do what you want them to do.

A different approach to swarm robotics is to use a swarm of much cheaper robots that are far less intelligent. In fact, they may not have to be intelligent at all, if you can rely on their physical characteristics to drive them instead. These swarms are “stochastic,” meaning that their motions are randomly determined, but if you’re clever and careful, you can still get them to do specific things.

Georgia Tech has developed some little swarm robots called “smarticles” that can’t really do much at all on their own, but once you put them together into a jumble, their randomness can actually accomplish something.

Honestly, calling these particle robots “smart” might be giving them a bit too much credit, because they’re actually kind of dumb and strictly speaking not capable of all that much on their own. A single smarticle weighs 35 grams, and consists of some little 3D-printed flappy bits attached to servos, plus an Arduino Pro Mini, a battery, and a light or sound sensor. When its little flappy bits are activated, each smarticle can move slightly, but a single one mostly just moves around in a square and then will gradually drift in a mostly random direction over time.

It gets more interesting when you throw a whole bunch of smarticles into a constrained area. A small collection of five or 10 smarticles constrained together form a “supersmarticle,” but besides being in close proximity to one another, the smarticles within the supersmarticle aren’t communicating or anything like that. As far as each smarticle is concerned, they’re independent, but weirdly, a bumble of them can work together without working together.

“These are very rudimentary robots whose behavior is dominated by mechanics and the laws of physics,” said Dan Goldman, a Dunn Family Professor in the School of Physics at the Georgia Institute of Technology.

The researchers noticed that if one small robot stopped moving, perhaps because its battery died, the group of smarticles would begin moving in the direction of that stalled robot. Graduate student Ross Warkentin learned he could control the movement by adding photo sensors to the robots that halt the arm flapping when a strong beam of light hits one of them.

“If you angle the flashlight just right, you can highlight the robot you want to be inactive, and that causes the ring to lurch toward or away from it, even though no robots are programmed to move toward the light,” Goldman said. “That allowed steering of the ensemble in a very rudimentary, stochastic way.”

It turns out that it’s possible to model this behavior, and control a supersmarticle with enough fidelity to steer it through a maze. And while these particular smarticles aren’t all that small, strictly speaking, the idea is to develop techniques that will work when robots are scaled way way down to the point where you can't physically fit useful computing in there at all.

The researchers are also working on some other concepts, like these:

Image: Science Robotics

The Georgia Tech researchers envision stochastic robot swarms that don’t have a perfectly defined shape or delineation but are capable of self-propulsion, relying on the ensemble-level behaviors that lead to collective locomotion. In such a robot, the researchers say, groups of largely generic agents may be able to achieve complex goals, as observed in biological collectives.

Er, yeah. I’m…not sure I really want there to be a bipedal humanoid robot built out of a bunch of tiny robots. Like, that seems creepy somehow, you know? I’m totally okay with slugs, but let’s not get crazy.

“A robot made of robots: Emergent transport and control of a smarticle ensemble, by William Savoie, Thomas A. Berrueta, Zachary Jackson, Ana Pervan, Ross Warkentin, Shengkai Li, Todd D. Murphey, Kurt Wiesenfeld, and Daniel I. Goldman” from the Georgia Institute of Technology, appears in the current issue of Science Robotics. Continue reading →

Posted in Human Robots

#435145 How Big Companies Can Simultaneously Run ...

Posted on May 28, 2019 by Android

We live in the age of entrepreneurs. New startups seem to appear out of nowhere and challenge not only established companies, but entire industries. Where startup unicorns were once mythical creatures, they now seem abundant, not only increasing in numbers but also in the speed with which they can gain the minimum one-billion-dollar valuations to achieve this status.

But no matter how well things go for innovative startups, how many new success stories we hear, and how much space they take up in the media, the story that they are the best or only source of innovation isn’t entirely accurate.

Established organizations, or legacy organizations, can be incredibly innovative too. And while innovation is much more difficult in established organizations than in startups because they have much more complex systems—nobody is more likely to succeed in their innovation efforts than established organizations.

Unlike startups, established organizations have all the resources. They have money, customers, data, suppliers, partners, and infrastructure, which put them in a far better position to transform new ideas into concrete, value-creating, successful offerings than startups.

However, for established organizations, becoming an innovation champion in these times of rapid change requires new rules of engagement.

Many organizations commit the mistake of engaging in innovation as if it were a homogeneous thing that should be approached in the same way every time, regardless of its purpose. In my book, Transforming Legacy Organizations, I argue that innovation in established organizations must actually be divided into three different tracks: optimizing, augmenting, and mutating innovation.

All three are important, and to complicate matters further, organizations must execute all three types of innovation at the same time.

Optimizing Innovation
The first track is optimizing innovation. This type of innovation is the majority of what legacy organizations already do today. It is, metaphorically speaking, the extra blade on the razor. A razor manufacturer might launch a new razor that has not just three, but four blades, to ensure an even better, closer, and more comfortable shave. Then one or two years later, they say they are now launching a razor that has not only four, but five blades for an even better, closer, and more comfortable shave. That is optimizing innovation.

Adding extra blades on the razor is where the established player reigns.

No startup with so much as a modicum of sense would even try to beat the established company in this type of innovation. And this continuous optimization, both on the operational and customer facing sides, is important. In the short term. It pays the rent. But it’s far from enough. There are limits to how many blades a razor needs, and optimizing innovation only improves upon the past.

Augmenting Innovation
Established players must also go beyond optimization and prepare for the future through augmenting innovation.

The digital transformation projects that many organizations are initiating can be characterized as augmenting innovation. In the first instance, it is about upgrading core offerings and processes from analog to digital. Or, if you’re born digital, you’ve probably had to augment the core to become mobile-first. Perhaps you have even entered the next augmentation phase, which involves implementing artificial intelligence. Becoming AI-first, like the Amazons, Microsofts, Baidus, and Googles of the world, requires great technological advancements. And it’s difficult. But technology may, in fact, be a minor part of the task.

The biggest challenge for augmenting innovation is probably culture.

Only legacy organizations that manage to transform their cultures from status quo cultures—cultures with a preference for things as they are—into cultures full of incremental innovators can thrive in constant change.

To create a strong innovation culture, an organization needs to thoroughly understand its immune systems. These are the mechanisms that protect the organization and operate around the clock to keep it healthy and stable, just as the body’s immune system operates to keep the body healthy and stable. But in a rapidly changing world, many of these defense mechanisms are no longer appropriate and risk weakening organizations’ innovation power.

When talking about organizational immune systems, there is a clear tendency to simply point to the individual immune system, people’s unwillingness to change.

But this is too simplistic.

Of course, there is human resistance to change, but the organizational immune system, consisting of a company’s key performance indicators (KPIs), rewards systems, legacy IT infrastructure and processes, and investor and shareholder demands, is far more important. So is the organization’s societal immune system, such as legislative barriers, legacy customers and providers, and economic climate.

Luckily, there are many culture hacks that organizations can apply to strengthen their innovation cultures by upgrading their physical and digital workspaces, transforming their top-down work processes into decentralized, agile ones, and empowering their employees.

Mutating Innovation
Upgrading your core and preparing for the future by augmenting innovation is crucial if you want success in the medium term. But to win in the long run and be as or more successful 20 to 30 years from now, you need to invent the future, and challenge your core, through mutating innovation.

This requires involving radical innovators who have a bold focus on experimenting with that which is not currently understood and for which a business case cannot be prepared.

Here you must also physically move away from the core organization when you initiate and run such initiatives. This is sometimes called “innovation on the edges” because the initiatives will not have a chance at succeeding within the core. It will be too noisy as they challenge what currently exists—precisely what the majority of the organization’s employees are working to optimize or augment.

Forward-looking organizations experiment to mutate their core through “X divisions,” sometimes called skunk works or innovation labs.

Lowe’s Innovation Labs, for instance, worked with startups to build in-store robot assistants and zero-gravity 3D printers to explore the future. Mutating innovation might include pursuing partnerships across all imaginable domains or establishing brand new companies, rather than traditional business units, as we see automakers such as Toyota now doing to build software for autonomous vehicles. Companies might also engage in radical open innovation by sponsoring others’ ingenuity. Japan’s top airline ANA is exploring a future of travel that does not involve flying people from point A to point B via the ANA Avatar XPRIZE competition.

Increasing technological opportunities challenge the core of any organization but also create unprecedented potential. No matter what product, service, or experience you create, you can’t rest on your laurels. You have to bring yourself to a position where you have a clear strategy for optimizing, augmenting, and mutating your core and thus transforming your organization.

It’s not an easy job. But, hey, if it were easy, everyone would be doing it. Those who make it, on the other hand, will be the innovation champions of the future.

Image Credit: rock-the-stock / Shutterstock.com

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Posted in Human Robots

#434865 5 AI Breakthroughs We’ll Likely See in ...

Posted on April 27, 2019 by Android

Convergence is accelerating disruption… everywhere! Exponential technologies are colliding into each other, reinventing products, services, and industries.

As AI algorithms such as Siri and Alexa can process your voice and output helpful responses, other AIs like Face++ can recognize faces. And yet others create art from scribbles, or even diagnose medical conditions.

Let’s dive into AI and convergence.

Top 5 Predictions for AI Breakthroughs (2019-2024)
My friend Neil Jacobstein is my ‘go-to expert’ in AI, with over 25 years of technical consulting experience in the field. Currently the AI and Robotics chair at Singularity University, Jacobstein is also a Distinguished Visiting Scholar in Stanford’s MediaX Program, a Henry Crown Fellow, an Aspen Institute moderator, and serves on the National Academy of Sciences Earth and Life Studies Committee. Neil predicted five trends he expects to emerge over the next five years, by 2024.

AI gives rise to new non-human pattern recognition and intelligence results

AlphaGo Zero, a machine learning computer program trained to play the complex game of Go, defeated the Go world champion in 2016 by 100 games to zero. But instead of learning from human play, AlphaGo Zero trained by playing against itself—a method known as reinforcement learning.

Building its own knowledge from scratch, AlphaGo Zero demonstrates a novel form of creativity, free of human bias. Even more groundbreaking, this type of AI pattern recognition allows machines to accumulate thousands of years of knowledge in a matter of hours.

While these systems can’t answer the question “What is orange juice?” or compete with the intelligence of a fifth grader, they are growing more and more strategically complex, merging with other forms of narrow artificial intelligence. Within the next five years, who knows what successors of AlphaGo Zero will emerge, augmenting both your business functions and day-to-day life.

Doctors risk malpractice when not using machine learning for diagnosis and treatment planning

A group of Chinese and American researchers recently created an AI system that diagnoses common childhood illnesses, ranging from the flu to meningitis. Trained on electronic health records compiled from 1.3 million outpatient visits of almost 600,000 patients, the AI program produced diagnosis outcomes with unprecedented accuracy.

While the US health system does not tout the same level of accessible universal health data as some Chinese systems, we’ve made progress in implementing AI in medical diagnosis. Dr. Kang Zhang, chief of ophthalmic genetics at the University of California, San Diego, created his own system that detects signs of diabetic blindness, relying on both text and medical images.

With an eye to the future, Jacobstein has predicted that “we will soon see an inflection point where doctors will feel it’s a risk to not use machine learning and AI in their everyday practices because they don’t want to be called out for missing an important diagnostic signal.”

Quantum advantage will massively accelerate drug design and testing

Researchers estimate that there are 1060 possible drug-like molecules—more than the number of atoms in our solar system. But today, chemists must make drug predictions based on properties influenced by molecular structure, then synthesize numerous variants to test their hypotheses.

Quantum computing could transform this time-consuming, highly costly process into an efficient, not to mention life-changing, drug discovery protocol.

“Quantum computing is going to have a major industrial impact… not by breaking encryption,” said Jacobstein, “but by making inroads into design through massive parallel processing that can exploit superposition and quantum interference and entanglement, and that can wildly outperform classical computing.”

AI accelerates security systems’ vulnerability and defense

With the incorporation of AI into almost every aspect of our lives, cyberattacks have grown increasingly threatening. “Deep attacks” can use AI-generated content to avoid both human and AI controls.

Previous examples include fake videos of former President Obama speaking fabricated sentences, and an adversarial AI fooling another algorithm into categorizing a stop sign as a 45 mph speed limit sign. Without the appropriate protections, AI systems can be manipulated to conduct any number of destructive objectives, whether ruining reputations or diverting autonomous vehicles.

Jacobstein’s take: “We all have security systems on our buildings, in our homes, around the healthcare system, and in air traffic control, financial organizations, the military, and intelligence communities. But we all know that these systems have been hacked periodically and we’re going to see that accelerate. So, there are major business opportunities there and there are major opportunities for you to get ahead of that curve before it bites you.”

AI design systems drive breakthroughs in atomically precise manufacturing

Just as the modern computer transformed our relationship with bits and information, AI will redefine and revolutionize our relationship with molecules and materials. AI is currently being used to discover new materials for clean-tech innovations, such as solar panels, batteries, and devices that can now conduct artificial photosynthesis.

Today, it takes about 15 to 20 years to create a single new material, according to industry experts. But as AI design systems skyrocket in capacity, these will vastly accelerate the materials discovery process, allowing us to address pressing issues like climate change at record rates. Companies like Kebotix are already on their way to streamlining the creation of chemistries and materials at the click of a button.

Atomically precise manufacturing will enable us to produce the previously unimaginable.

Final Thoughts
Within just the past three years, countries across the globe have signed into existence national AI strategies and plans for ramping up innovation. Businesses and think tanks have leaped onto the scene, hiring AI engineers and tech consultants to leverage what computer scientist Andrew Ng has even called the new ‘electricity’ of the 21st century.

As AI plays an exceedingly vital role in everyday life, how will your business leverage it to keep up and build forward?

In the wake of burgeoning markets, new ventures will quickly arise, each taking advantage of untapped data sources or unmet security needs.

And as your company aims to ride the wave of AI’s exponential growth, consider the following pointers to leverage AI and disrupt yourself before it reaches you first:

Determine where and how you can begin collecting critical data to inform your AI algorithms
Identify time-intensive processes that can be automated and accelerated within your company
Discern which global challenges can be expedited by hyper-fast, all-knowing minds

Remember: good data is vital fuel. Well-defined problems are the best compass. And the time to start implementing AI is now.

Join Me
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Image Credit: Yurchanka Siarhei / Shutterstock.com Continue reading →

Posted in Human Robots

#434792 Extending Human Longevity With ...

Posted on March 28, 2019 by Android

Lizards can regrow entire limbs. Flatworms, starfish, and sea cucumbers regrow entire bodies. Sharks constantly replace lost teeth, often growing over 20,000 teeth throughout their lifetimes. How can we translate these near-superpowers to humans?

The answer: through the cutting-edge innovations of regenerative medicine.

While big data and artificial intelligence transform how we practice medicine and invent new treatments, regenerative medicine is about replenishing, replacing, and rejuvenating our physical bodies.

In Part 5 of this blog series on Longevity and Vitality, I detail three of the regenerative technologies working together to fully augment our vital human organs.

Replenish: Stem cells, the regenerative engine of the body
Replace: Organ regeneration and bioprinting
Rejuvenate: Young blood and parabiosis

Let’s dive in.

Replenish: Stem Cells – The Regenerative Engine of the Body
Stem cells are undifferentiated cells that can transform into specialized cells such as heart, neurons, liver, lung, skin and so on, and can also divide to produce more stem cells.

In a child or young adult, these stem cells are in large supply, acting as a built-in repair system. They are often summoned to the site of damage or inflammation to repair and restore normal function.

But as we age, our supply of stem cells begins to diminish as much as 100- to 10,000-fold in different tissues and organs. In addition, stem cells undergo genetic mutations, which reduce their quality and effectiveness at renovating and repairing your body.

Imagine your stem cells as a team of repairmen in your newly constructed mansion. When the mansion is new and the repairmen are young, they can fix everything perfectly. But as the repairmen age and reduce in number, your mansion eventually goes into disrepair and finally crumbles.

What if you could restore and rejuvenate your stem cell population?

One option to accomplish this restoration and rejuvenation is to extract and concentrate your own autologous adult stem cells from places like your adipose (or fat) tissue or bone marrow.

These stem cells, however, are fewer in number and have undergone mutations (depending on your age) from their original ‘software code.’ Many scientists and physicians now prefer an alternative source, obtaining stem cells from the placenta or umbilical cord, the leftovers of birth.

These stem cells, available in large supply and expressing the undamaged software of a newborn, can be injected into joints or administered intravenously to rejuvenate and revitalize.

Think of these stem cells as chemical factories generating vital growth factors that can help to reduce inflammation, fight autoimmune disease, increase muscle mass, repair joints, and even revitalize skin and grow hair.

Over the last decade, the number of publications per year on stem cell-related research has increased 40x, and the stem cell market is expected to increase to $297 billion by 2022.

Rising research and development initiatives to develop therapeutic options for chronic diseases and growing demand for regenerative treatment options are the most significant drivers of this budding industry.

Biologists led by Kohji Nishida at Osaka University in Japan have discovered a new way to nurture and grow the tissues that make up the human eyeball. The scientists are able to grow retinas, corneas, the eye’s lens, and more, using only a small sample of adult skin.

In a Stanford study, seven of 18 stroke victims who agreed to stem cell treatments showed remarkable motor function improvements. This treatment could work for other neurodegenerative conditions such as Alzheimer’s, Parkinson’s, and ALS.

Doctors from the USC Neurorestoration Center and Keck Medicine of USC injected stem cells into the damaged cervical spine of a recently paralyzed 21-year-old man. Three months later, he showed dramatic improvement in sensation and movement of both arms.

In 2019, doctors in the U.K. cured a patient with HIV for the second time ever thanks to the efficacy of stem cells. After giving the cancer patient (who also had HIV) an allogeneic haematopoietic (e.g. blood) stem cell treatment for his Hodgkin’s lymphoma, the patient went into long-term HIV remission—18 months and counting at the time of the study’s publication.

Replace: Organ Regeneration and 3D Printing
Every 10 minutes, someone is added to the US organ transplant waiting list, totaling over 113,000 people waiting for replacement organs as of January 2019.

Countless more people in need of ‘spare parts’ never make it onto the waiting list. And on average, 20 people die each day while waiting for a transplant.

As a result, 35 percent of all US deaths (~900,000 people) could be prevented or delayed with access to organ replacements.

The excessive demand for donated organs will only intensify as technologies like self-driving cars make the world safer, given that many organ donors result from auto and motorcycle accidents. Safer vehicles mean less accidents and donations.

Clearly, replacement and regenerative medicine represent a massive opportunity.

Organ Entrepreneurs
Enter United Therapeutics CEO, Dr. Martine Rothblatt. A one-time aerospace entrepreneur (she was the founder of Sirius Satellite Radio), Rothblatt changed careers in the 1990s after her daughter developed a rare lung disease.

Her moonshot today is to create an industry of replacement organs. With an initial focus on diseases of the lung, Rothblatt set out to create replacement lungs. To accomplish this goal, her company United Therapeutics has pursued a number of technologies in parallel.

3D Printing Lungs
In 2017, United teamed up with one of the world’s largest 3D printing companies, 3D Systems, to build a collagen bioprinter and is paying another company, 3Scan, to slice up lungs and create detailed maps of their interior.

This 3D Systems bioprinter now operates according to a method called stereolithography. A UV laser flickers through a shallow pool of collagen doped with photosensitive molecules. Wherever the laser lingers, the collagen cures and becomes solid.

Gradually, the object being printed is lowered and new layers are added. The printer can currently lay down collagen at a resolution of around 20 micrometers, but will need to achieve resolution of a micrometer in size to make the lung functional.

Once a collagen lung scaffold has been printed, the next step is to infuse it with human cells, a process called recellularization.

The goal here is to use stem cells that grow on scaffolding and differentiate, ultimately providing the proper functionality. Early evidence indicates this approach can work.

In 2018, Harvard University experimental surgeon Harald Ott reported that he pumped billions of human cells (from umbilical cords and diced lungs) into a pig lung stripped of its own cells. When Ott’s team reconnected it to a pig’s circulation, the resulting organ showed rudimentary function.

Humanizing Pig Lungs
Another of Rothblatt’s organ manufacturing strategies is called xenotransplantation, the idea of transplanting an animal’s organs into humans who need a replacement.

Given the fact that adult pig organs are similar in size and shape to those of humans, United Therapeutics has focused on genetically engineering pigs to allow humans to use their organs. “It’s actually not rocket science,” said Rothblatt in her 2015 TED talk. “It’s editing one gene after another.”

To accomplish this goal, United Therapeutics made a series of investments in companies such as Revivicor Inc. and Synthetic Genomics Inc., and signed large funding agreements with the University of Maryland, University of Alabama, and New York Presbyterian/Columbia University Medical Center to create xenotransplantation programs for new hearts, kidneys, and lungs, respectively. Rothblatt hopes to see human translation in three to four years.

In preparation for that day, United Therapeutics owns a 132-acre property in Research Triangle Park and built a 275,000-square-foot medical laboratory that will ultimately have the capability to annually produce up to 1,000 sets of healthy pig lungs—known as xenolungs—from genetically engineered pigs.

Lung Ex Vivo Perfusion Systems
Beyond 3D printing and genetically engineering pig lungs, Rothblatt has already begun implementing a third near-term approach to improve the supply of lungs across the US.

Only about 30 percent of potential donor lungs meet transplant criteria in the first place; of those, only about 85 percent of those are usable once they arrive at the surgery center. As a result, nearly 75 percent of possible lungs never make it to the recipient in need.

What if these lungs could be rejuvenated? This concept informs Dr. Rothblatt’s next approach.

In 2016, United Therapeutics invested $41.8 million in TransMedics Inc., an Andover, Massachusetts company that develops ex vivo perfusion systems for donor lungs, hearts, and kidneys.

The XVIVO Perfusion System takes marginal-quality lungs that initially failed to meet transplantation standard-of-care criteria and perfuses and ventilates them at normothermic conditions, providing an opportunity for surgeons to reassess transplant suitability.

Rejuvenate Young Blood and Parabiosis
In HBO’s parody of the Bay Area tech community, Silicon Valley, one of the episodes (Season 4, Episode 5) is named “The Blood Boy.”

In this installment, tech billionaire Gavin Belson (Matt Ross) is meeting with Richard Hendricks (Thomas Middleditch) and his team, speaking about the future of the decentralized internet. A young, muscled twenty-something disrupts the meeting when he rolls in a transfusion stand and silently hooks an intravenous connection between himself and Belson.

Belson then introduces the newcomer as his “transfusion associate” and begins to explain the science of parabiosis: “Regular transfusions of the blood of a younger physically fit donor can significantly retard the aging process.”

While the sitcom is fiction, that science has merit, and the scenario portrayed in the episode is already happening today.

On the first point, research at Stanford and Harvard has demonstrated that older animals, when transfused with the blood of young animals, experience regeneration across many tissues and organs.

The opposite is also true: young animals, when transfused with the blood of older animals, experience accelerated aging. But capitalizing on this virtual fountain of youth has been tricky.

Ambrosia
One company, a San Francisco-based startup called Ambrosia, recently commenced one of the trials on parabiosis. Their protocol is simple: Healthy participants aged 35 and older get a transfusion of blood plasma from donors under 25, and researchers monitor their blood over the next two years for molecular indicators of health and aging.

Ambrosia’s founder Jesse Karmazin became interested in launching a company around parabiosis after seeing impressive data from animals and studies conducted abroad in humans: In one trial after another, subjects experience a reversal of aging symptoms across every major organ system. “The effects seem to be almost permanent,” he said. “It’s almost like there’s a resetting of gene expression.”

Infusing your own cord blood stem cells as you age may have tremendous longevity benefits. Following an FDA press release in February 2019, Ambrosia halted its consumer-facing treatment after several months of operation.

Understandably, the FDA raised concerns about the practice of parabiosis because to date, there is a marked lack of clinical data to support the treatment’s effectiveness.

Elevian
On the other end of the reputability spectrum is a startup called Elevian, spun out of Harvard University. Elevian is approaching longevity with a careful, scientifically validated strategy. (Full Disclosure: I am both an advisor to and investor in Elevian.)

CEO Mark Allen, MD, is joined by a dozen MDs and Ph.Ds out of Harvard. Elevian’s scientific founders started the company after identifying specific circulating factors that may be responsible for the “young blood” effect.

One example: A naturally occurring molecule known as “growth differentiation factor 11,” or GDF11, when injected into aged mice, reproduces many of the regenerative effects of young blood, regenerating heart, brain, muscles, lungs, and kidneys.

More specifically, GDF11 supplementation reduces age-related cardiac hypertrophy, accelerates skeletal muscle repair, improves exercise capacity, improves brain function and cerebral blood flow, and improves metabolism.

Elevian is developing a number of therapeutics that regulate GDF11 and other circulating factors. The goal is to restore our body’s natural regenerative capacity, which Elevian believes can address some of the root causes of age-associated disease with the promise of reversing or preventing many aging-related diseases and extending the healthy lifespan.

Conclusion
In 1992, futurist Leland Kaiser coined the term “regenerative medicine”:

“A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.”

Since then, the powerful regenerative medicine industry has grown exponentially, and this rapid growth is anticipated to continue.

A dramatic extension of the human healthspan is just over the horizon. Soon, we’ll all have the regenerative superpowers previously relegated to a handful of animals and comic books.

What new opportunities open up when anybody, anywhere, and at anytime can regenerate, replenish, and replace entire organs and metabolic systems on command?

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