Tag Archives: society

#437882 Video Friday: MIT Mini-Cheetah Robots ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

ICCR 2020 – December 26-29, 2020 – [Online Conference]
HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
Let us know if you have suggestions for next week, and enjoy today's videos.

What a lovely Christmas video from Norlab.

[ Norlab ]

Thanks Francois!

MIT Mini-Cheetahs are looking for a new home. Our new cheetah cubs, born at NAVER LABS, are for the MIT Mini-Cheetah workshop. MIT professor Sangbae Kim and his research team are supporting joint research by distributing Mini-Cheetahs to researchers all around the world.

[ NAVER Labs ]

For several years, NVIDIA’s research teams have been working to leverage GPU technology to accelerate reinforcement learning (RL). As a result of this promising research, NVIDIA is pleased to announce a preview release of Isaac Gym – NVIDIA’s physics simulation environment for reinforcement learning research. RL-based training is now more accessible as tasks that once required thousands of CPU cores can now instead be trained using a single GPU.

[ NVIDIA ]

At SINTEF in Norway, they're working on ways of using robots to keep tabs on giant floating cages of tasty fish:

One of the tricky things about operating robots in an environment like this is localization, so SINTEF is working on a solution that uses beacons:

While that video shows a lot of simulation (because otherwise there are tons of fish in the way), we're told that the autonomous navigation has been successfully demonstrated with an ROV in “a full scale fish farm with up to 200.000 salmon swimming around the robot.”

[ SINTEF ]

Thanks Eleni!

We’ve been getting ready for the snow in the most BG way possible. Wishing all of you a happy and healthy holiday season.

[ Berkshire Grey ]

ANYbotics doesn’t care what time of the year it is, so Happy Easter!

And here's a little bit about why ANYmal C looks the way it does.

[ ANYbotics ]

Robert “Buz” Chmielewski is using two modular prosthetic limbs developed by APL to feed himself dessert. Smart software puts his utensils in roughly the right spot, and then Buz uses his brain signals to cut the food with knife and fork. Once he is done cutting, the software then brings the food near his mouth, where he again uses brain signals to bring the food the last several inches to his mouth so that he can eat it.

[ JHUAPL ]

Introducing VESPER: a new military-grade small drone that is designed, sourced and built in the United States. Vesper offers a 50-minutes flight time, with speeds up to 45 mph (72 kph) and a total flight range of 25 miles (45 km). The magnetic snap-together architecture enables extremely fast transitions: the battery, props and rotor set can each be swapped in <5 seconds.

[ Vantage Robotics ]

In this video, a multi-material robot simulator is used to design a shape-changing robot, which is then transferred to physical hardware. The simulated and real robots can use shape change to switch between rolling gaits and inchworm gaits, to locomote in multiple environments.

[ Yale Faboratory ]

Get a preview of the cave environments that are being used to inspire the Final Event competition course of the DARPA Subterranean Challenge. In the Final Event, teams will deploy their robots to rapidly map, navigate, and search in competition courses that combine elements of man-made tunnel systems, urban underground, and natural cave networks!

The reason to pay attention this particular video is that it gives us some idea of what DARPA means when they say "cave."

[ SubT ]

MQ25 takes another step toward unmanned aerial refueling for the U.S. Navy. The MQ-25 test asset has flown for the first time with an aerial refueling pod containing the hose and basket that will make it an aerial refueler.

[ Boeing ]

We present a unified model-based and data-driven approach for quadrupedal planning and control to achieve dynamic locomotion over uneven terrain. We utilize on-board proprioceptive and exteroceptive feedback to map sensory information and desired base velocity commands into footstep plans using a reinforcement learning (RL) policy trained in simulation over a wide range of procedurally generated terrains.

[ DRS ]

The video shows the results of the German research project RoPHa. Within the project, the partners developed technologies for two application scenarios with the service robot Care-O-bot 4 in order to support people in need of help when eating.

[ RoPHa Project ]

Thanks Jenny!

This looks like it would be fun, if you are a crazy person.

[ Team BlackSheep ]

Robot accuracy is the limiting factor in many industrial applications. Manufacturers often only specify the pose repeatability values of their robotic systems. Fraunhofer IPA has set up a testing environment for automated measuring of accuracy performance criteria of industrial robots. Following the procedures defined in norm ISO 9283 allows generating reliable and repeatable results. They can be the basis for targeted measures increasing the robotic system’s accuracy.

[ Fraunhofer ]

Thanks Jenny!

The IEEE Women in Engineering – Robotics and Automation Society (WIE-RAS) hosted an online panel on best practices for teaching robotics. The diverse panel boasts experts in robotics education from a variety of disciplines, institutions, and areas of expertise.

[ IEEE RAS ]

Northwestern researchers have developed a first-of-its-kind soft, aquatic robot that is powered by light and rotating magnetic fields. These life-like robotic materials could someday be used as "smart" microscopic systems for production of fuels and drugs, environmental cleanup or transformative medical procedures.

[ Northwestern ]

Tech United Eindhoven's soccer robots now have eight wheels instead of four wheels, making them tweleve times better, if my math is right.

[ TU Eindhoven ] Continue reading

Posted in Human Robots

#437816 As Algorithms Take Over More of the ...

Algorithms play an increasingly prominent part in our lives, governing everything from the news we see to the products we buy. As they proliferate, experts say, we need to make sure they don’t collude against us in damaging ways.

Fears of malevolent artificial intelligence plotting humanity’s downfall are a staple of science fiction. But there are plenty of nearer-term situations in which relatively dumb algorithms could do serious harm unintentionally, particularly when they are interlocked in complex networks of relationships.

In the economic sphere a high proportion of decision-making is already being offloaded to machines, and there have been warning signs of where that could lead if we’re not careful. The 2010 “Flash Crash,” where algorithmic traders helped wipe nearly $1 trillion off the stock market in minutes, is a textbook example, and widespread use of automated trading software has been blamed for the increasing fragility of markets.

But another important place where algorithms could undermine our economic system is in price-setting. Competitive markets are essential for the smooth functioning of the capitalist system that underpins Western society, which is why countries like the US have strict anti-trust laws that prevent companies from creating monopolies or colluding to build cartels that artificially inflate prices.

These regulations were built for an era when pricing decisions could always be traced back to a human, though. As self-adapting pricing algorithms increasingly decide the value of products and commodities, those laws are starting to look unfit for purpose, say the authors of a paper in Science.

Using algorithms to quickly adjust prices in a dynamic market is not a new idea—airlines have been using them for decades—but previously these algorithms operated based on rules that were hard-coded into them by programmers.

Today the pricing algorithms that underpin many marketplaces, especially online ones, rely on machine learning instead. After being set an overarching goal like maximizing profit, they develop their own strategies based on experience of the market, often with little human oversight. The most advanced also use forms of AI whose workings are opaque even if humans wanted to peer inside.

In addition, the public nature of online markets means that competitors’ prices are available in real time. It’s well-documented that major retailers like Amazon and Walmart are engaged in a never-ending bot war, using automated software to constantly snoop on their rivals’ pricing and inventory.

This combination of factors sets the stage perfectly for AI-powered pricing algorithms to adopt collusive pricing strategies, say the authors. If given free reign to develop their own strategies, multiple pricing algorithms with real-time access to each other’s prices could quickly learn that cooperating with each other is the best way to maximize profits.

The authors note that researchers have already found evidence that pricing algorithms will spontaneously develop collusive strategies in computer-simulated markets, and a recent study found evidence that suggests pricing algorithms may be colluding in Germany’s retail gasoline market. And that’s a problem, because today’s anti-trust laws are ill-suited to prosecuting this kind of behavior.

Collusion among humans typically involves companies communicating with each other to agree on a strategy that pushes prices above the true market value. They then develop rules to determine how they maintain this markup in a dynamic market that also incorporates the threat of retaliatory pricing to spark a price war if another cartel member tries to undercut the agreed pricing strategy.

Because of the complexity of working out whether specific pricing strategies or prices are the result of collusion, prosecutions have instead relied on communication between companies to establish guilt. That’s a problem because algorithms don’t need to communicate to collude, and as a result there are few legal mechanisms to prosecute this kind of collusion.

That means legal scholars, computer scientists, economists, and policymakers must come together to find new ways to uncover, prohibit, and prosecute the collusive rules that underpin this behavior, say the authors. Key to this will be auditing and testing pricing algorithms, looking for things like retaliatory pricing, price matching, and aggressive responses to price drops but not price rises.

Once collusive pricing rules are uncovered, computer scientists need to come up with ways to constrain algorithms from adopting them without sacrificing their clear efficiency benefits. It could also be helpful to make preventing this kind of collusive behavior the responsibility of the companies deploying them, with stiff penalties for those who don’t keep their algorithms in check.

One problem, though, is that algorithms may evolve strategies that humans would never think of, which could make spotting this behavior tricky. Imbuing courts with the technical knowledge and capacity to investigate this kind of evidence will also prove difficult, but getting to grips with these problems is an even more pressing challenge than it might seem at first.

While anti-competitive pricing algorithms could wreak havoc, there are plenty of other arenas where collusive AI could have even more insidious effects, from military applications to healthcare and insurance. Developing the capacity to predict and prevent AI scheming against us will likely be crucial going forward.

Image Credit: Pexels from Pixabay Continue reading

Posted in Human Robots

#437809 Q&A: The Masterminds Behind ...

Illustration: iStockphoto

Getting a car to drive itself is undoubtedly the most ambitious commercial application of artificial intelligence (AI). The research project was kicked into life by the 2004 DARPA Urban Challenge and then taken up as a business proposition, first by Alphabet, and later by the big automakers.

The industry-wide effort vacuumed up many of the world’s best roboticists and set rival companies on a multibillion-dollar acquisitions spree. It also launched a cycle of hype that paraded ever more ambitious deadlines—the most famous of which, made by Alphabet’s Sergei Brin in 2012, was that full self-driving technology would be ready by 2017. Those deadlines have all been missed.

Much of the exhilaration was inspired by the seeming miracles that a new kind of AI—deep learning—was achieving in playing games, recognizing faces, and transliterating voices. Deep learning excels at tasks involving pattern recognition—a particular challenge for older, rule-based AI techniques. However, it now seems that deep learning will not soon master the other intellectual challenges of driving, such as anticipating what human beings might do.

Among the roboticists who have been involved from the start are Gill Pratt, the chief executive officer of Toyota Research Institute (TRI) , formerly a program manager at the Defense Advanced Research Projects Agency (DARPA); and Wolfram Burgard, vice president of automated driving technology for TRI and president of the IEEE Robotics and Automation Society. The duo spoke with IEEE Spectrum’s Philip Ross at TRI’s offices in Palo Alto, Calif.

This interview has been condensed and edited for clarity.

IEEE Spectrum: How does AI handle the various parts of the self-driving problem?

Photo: Toyota

Gill Pratt

Gill Pratt: There are three different systems that you need in a self-driving car: It starts with perception, then goes to prediction, and then goes to planning.

The one that by far is the most problematic is prediction. It’s not prediction of other automated cars, because if all cars were automated, this problem would be much more simple. How do you predict what a human being is going to do? That’s difficult for deep learning to learn right now.

Spectrum: Can you offset the weakness in prediction with stupendous perception?

Photo: Toyota Research Institute for Burgard

Wolfram Burgard

Wolfram Burgard: Yes, that is what car companies basically do. A camera provides semantics, lidar provides distance, radar provides velocities. But all this comes with problems, because sometimes you look at the world from different positions—that’s called parallax. Sometimes you don’t know which range estimate that pixel belongs to. That might make the decision complicated as to whether that is a person painted onto the side of a truck or whether this is an actual person.

With deep learning there is this promise that if you throw enough data at these networks, it’s going to work—finally. But it turns out that the amount of data that you need for self-driving cars is far larger than we expected.

Spectrum: When do deep learning’s limitations become apparent?

Pratt: The way to think about deep learning is that it’s really high-performance pattern matching. You have input and output as training pairs; you say this image should lead to that result; and you just do that again and again, for hundreds of thousands, millions of times.

Here’s the logical fallacy that I think most people have fallen prey to with deep learning. A lot of what we do with our brains can be thought of as pattern matching: “Oh, I see this stop sign, so I should stop.” But it doesn’t mean all of intelligence can be done through pattern matching.

“I asked myself, if all of those cars had automated drive, how good would they have to be to tolerate the number of crashes that would still occur?”
—Gill Pratt, Toyota Research Institute

For instance, when I’m driving and I see a mother holding the hand of a child on a corner and trying to cross the street, I am pretty sure she’s not going to cross at a red light and jaywalk. I know from my experience being a human being that mothers and children don’t act that way. On the other hand, say there are two teenagers—with blue hair, skateboards, and a disaffected look. Are they going to jaywalk? I look at that, you look at that, and instantly the probability in your mind that they’ll jaywalk is much higher than for the mother holding the hand of the child. It’s not that you’ve seen 100,000 cases of young kids—it’s that you understand what it is to be either a teenager or a mother holding a child’s hand.

You can try to fake that kind of intelligence. If you specifically train a neural network on data like that, you could pattern-match that. But you’d have to know to do it.

Spectrum: So you’re saying that when you substitute pattern recognition for reasoning, the marginal return on the investment falls off pretty fast?

Pratt: That’s absolutely right. Unfortunately, we don’t have the ability to make an AI that thinks yet, so we don’t know what to do. We keep trying to use the deep-learning hammer to hammer more nails—we say, well, let’s just pour more data in, and more data.

Spectrum: Couldn’t you train the deep-learning system to recognize teenagers and to assign the category a high propensity for jaywalking?

Burgard: People have been doing that. But it turns out that these heuristics you come up with are extremely hard to tweak. Also, sometimes the heuristics are contradictory, which makes it extremely hard to design these expert systems based on rules. This is where the strength of the deep-learning methods lies, because somehow they encode a way to see a pattern where, for example, here’s a feature and over there is another feature; it’s about the sheer number of parameters you have available.

Our separation of the components of a self-driving AI eases the development and even the learning of the AI systems. Some companies even think about using deep learning to do the job fully, from end to end, not having any structure at all—basically, directly mapping perceptions to actions.

Pratt: There are companies that have tried it; Nvidia certainly tried it. In general, it’s been found not to work very well. So people divide the problem into blocks, where we understand what each block does, and we try to make each block work well. Some of the blocks end up more like the expert system we talked about, where we actually code things, and other blocks end up more like machine learning.

Spectrum: So, what’s next—what new technique is in the offing?

Pratt: If I knew the answer, we’d do it. [Laughter]

Spectrum: You said that if all cars on the road were automated, the problem would be easy. Why not “geofence” the heck out of the self-driving problem, and have areas where only self-driving cars are allowed?

Pratt: That means putting in constraints on the operational design domain. This includes the geography—where the car should be automated; it includes the weather, it includes the level of traffic, it includes speed. If the car is going slow enough to avoid colliding without risking a rear-end collision, that makes the problem much easier. Street trolleys operate with traffic still in some parts of the world, and that seems to work out just fine. People learn that this vehicle may stop at unexpected times. My suspicion is, that is where we’ll see Level 4 autonomy in cities. It’s going to be in the lower speeds.

“We are now in the age of deep learning, and we don’t know what will come after.”
—Wolfram Burgard, Toyota Research Institute

That’s a sweet spot in the operational design domain, without a doubt. There’s another one at high speed on a highway, because access to highways is so limited. But unfortunately there is still the occasional debris that suddenly crosses the road, and the weather gets bad. The classic example is when somebody irresponsibly ties a mattress to the top of a car and it falls off; what are you going to do? And the answer is that terrible things happen—even for humans.

Spectrum: Learning by doing worked for the first cars, the first planes, the first steam boilers, and even the first nuclear reactors. We ran risks then; why not now?

Pratt: It has to do with the times. During the era where cars took off, all kinds of accidents happened, women died in childbirth, all sorts of diseases ran rampant; the expected characteristic of life was that bad things happened. Expectations have changed. Now the chance of dying in some freak accident is quite low because of all the learning that’s gone on, the OSHA [Occupational Safety and Health Administration] rules, UL code for electrical appliances, all the building standards, medicine.

Furthermore—and we think this is very important—we believe that empathy for a human being at the wheel is a significant factor in public acceptance when there is a crash. We don’t know this for sure—it’s a speculation on our part. I’ve driven, I’ve had close calls; that could have been me that made that mistake and had that wreck. I think people are more tolerant when somebody else makes mistakes, and there’s an awful crash. In the case of an automated car, we worry that that empathy won’t be there.

Photo: Toyota

Toyota is using this
Platform 4 automated driving test vehicle, based on the Lexus LS, to develop Level-4 self-driving capabilities for its “Chauffeur” project.

Spectrum: Toyota is building a system called Guardian to back up the driver, and a more futuristic system called Chauffeur, to replace the driver. How can Chauffeur ever succeed? It has to be better than a human plus Guardian!

Pratt: In the discussions we’ve had with others in this field, we’ve talked about that a lot. What is the standard? Is it a person in a basic car? Or is it a person with a car that has active safety systems in it? And what will people think is good enough?

These systems will never be perfect—there will always be some accidents, and no matter how hard we try there will still be occasions where there will be some fatalities. At what threshold are people willing to say that’s okay?

Spectrum: You were among the first top researchers to warn against hyping self-driving technology. What did you see that so many other players did not?

Pratt: First, in my own case, during my time at DARPA I worked on robotics, not cars. So I was somewhat of an outsider. I was looking at it from a fresh perspective, and that helps a lot.

Second, [when I joined Toyota in 2015] I was joining a company that is very careful—even though we have made some giant leaps—with the Prius hybrid drive system as an example. Even so, in general, the philosophy at Toyota is kaizen—making the cars incrementally better every single day. That care meant that I was tasked with thinking very deeply about this thing before making prognostications.

And the final part: It was a new job for me. The first night after I signed the contract I felt this incredible responsibility. I couldn’t sleep that whole night, so I started to multiply out the numbers, all using a factor of 10. How many cars do we have on the road? Cars on average last 10 years, though ours last 20, but let’s call it 10. They travel on an order of 10,000 miles per year. Multiply all that out and you get 10 to the 10th miles per year for our fleet on Planet Earth, a really big number. I asked myself, if all of those cars had automated drive, how good would they have to be to tolerate the number of crashes that would still occur? And the answer was so incredibly good that I knew it would take a long time. That was five years ago.

Burgard: We are now in the age of deep learning, and we don’t know what will come after. We are still making progress with existing techniques, and they look very promising. But the gradient is not as steep as it was a few years ago.

Pratt: There isn’t anything that’s telling us that it can’t be done; I should be very clear on that. Just because we don’t know how to do it doesn’t mean it can’t be done. Continue reading

Posted in Human Robots

#437783 Ex-Googler’s Startup Comes Out of ...

Over the last 10 years, the PR2 has helped roboticists make an enormous amount of progress in mobile manipulation over a relatively short time. I mean, it’s been a decade already, but still—robots are hard, and giving a bunch of smart people access to a capable platform where they didn’t have to worry about hardware and could instead focus on doing interesting and useful things helped to establish a precedent for robotics research going forward.

Unfortunately, not everyone can afford an enormous US $400,000 robot, and even if they could, PR2s are getting very close to the end of their lives. There are other mobile manipulators out there taking the place of the PR2, but so far, size and cost have largely restricted them to research labs. Lots of good research is being done, but it’s getting to the point where folks want to take the next step: making mobile manipulators real-world useful.

Today, a company called Hello Robot is announcing a new mobile manipulator called the Stretch RE1. With offices in the San Francisco Bay Area and in Atlanta, Ga., Hello Robot is led by Aaron Edsinger and Charlie Kemp, and by combining decades of experience in industry and academia they’ve managed to come up with a robot that’s small, lightweight, capable, and affordable, all at the same time. For now, it’s a research platform, but eventually, its creators hope that it will be able to come into our homes and take care of us when we need it to.

A fresh look at mobile manipulators
To understand the concept behind Stretch, it’s worth taking a brief look back at what Edsinger and Kemp have been up to for the past 10 years. Edsinger co-founded Meka Robotics in 2007, which built expensive, high performance humanoid arms, torsos, and heads for the research market. Meka was notable for being the first robotics company (as far as we know) to sell robot arms that used series elastic actuators, and the company worked extensively with Georgia Tech researchers. In 2011, Edsinger was one of the co-founders of Redwood Robotics (along with folks from SRI and Willow Garage), which was going to develop some kind of secret and amazing new robot arm before Google swallowed it in late 2013. At the same time, Google also acquired Meka and a bunch of other robotics companies, and Edsinger ended up at Google as one of the directors of its robotics program, until he left to co-found Hello Robot in 2017.

Meanwhile, since 2007 Kemp has been a robotics professor at Georgia Tech, where he runs the Healthcare Robotics Lab. Kemp’s lab was one of the 11 PR2 beta sites, giving him early experience with a ginormous mobile manipulator. Much of the research that Kemp has spent the last decade on involves robots providing assistance to untrained users, often through direct physical contact, and frequently either in their own homes or in a home environment. We should mention that the Georgia Tech PR2 is still going, most recently doing some clever material classification work in a paper for IROS later this year.

Photo: Hello Robot

Hello Robot co-founder and CEO Aaron Edsinger says that, although Stretch is currently a research platform, he hopes to see the robot deployed in home environments, adding that the “impact we want to have is through robots that are helpful to people in society.”

So with all that in mind, where’d Hello Robot come from? As it turns out, both Edsinger and Kemp were in Rodney Brooks’ group at MIT, so it’s perhaps not surprising that they share some of the same philosophies about what robots should be and what they should be used for. After collaborating on a variety of projects over the years, in 2017 Edsinger was thinking about his next step after Google when Kemp stopped by to show off some video of a new robot prototype that he’d been working on—the prototype for Stretch. “As soon as I saw it, I knew that was exactly the kind of thing I wanted to be working on,” Edsinger told us. “I’d become frustrated with the complexity of the robots being built to do manipulation in home environments and around people, and it solved a lot of problems in an elegant way.”

For Kemp, Stretch is an attempt to get everything he’s been teaching his robots out of his lab at Georgia Tech and into the world where it can actually be helpful to people. “Right from the beginning, we were trying to take our robots out to real homes and interact with real people,” says Kemp. Georgia Tech’s PR2, for example, worked extensively with Henry and Jane Evans, helping Henry (a quadriplegic) regain some of the bodily autonomy he had lost. With the assistance of the PR2, Henry was able to keep himself comfortable for hours without needing a human caregiver to be constantly with him. “I felt like I was making a commitment in some ways to some of the people I was working with,” Kemp told us. “But 10 years later, I was like, where are these things? I found that incredibly frustrating. Stretch is an effort to try to push things forward.”

A robot you can put in the backseat of a car
One way to put Stretch in context is to think of it almost as a reaction to the kitchen sink philosophy of the PR2. Where the PR2 was designed to be all the robot anyone could ever need (plus plenty of robot that nobody really needed) embodied in a piece of hardware that weighs 225 kilograms and cost nearly half a million dollars, Stretch is completely focused on being just the robot that is actually necessary in a form factor that’s both much smaller and affordable. The entire robot weighs a mere 23 kg in a footprint that’s just a 34 cm square. As you can see from the video, it’s small enough (and safe enough) that it can be moved by a child. The cost? At $17,950 apiece—or a bit less if you buy a bunch at once—Stretch costs a fraction of what other mobile manipulators sell for.

It might not seem like size or weight should be that big of an issue, but it very much is, explains Maya Cakmak, a robotics professor at the University of Washington, in Seattle. Cakmak worked with PR2 and Henry Evans when she was at Willow Garage, and currently has access to both a PR2 and a Fetch research robot. “When I think about my long term research vision, I want to deploy service robots in real homes,” Cakmak told us. Unfortunately, it’s the robots themselves that have been preventing her from doing this—both the Fetch and the PR2 are large enough that moving them anywhere requires a truck and a lift, which also limits the home that they can be used in. “For me, I felt immediately that Stretch is very different, and it makes a lot of sense,” she says. “It’s safe and lightweight, you can probably put it in the backseat of a car.” For Cakmak, Stretch’s size is the difference between being able to easily take a robot to the places she wants to do research in, and not. And cost is a factor as well, since a cheaper robot means more access for her students. “I got my refurbished PR2 for $180,000,” Cakmak says. “For that, with Stretch I could have 10!”

“I felt immediately that Stretch is very different. It’s safe and lightweight, you can probably put it in the backseat of a car. I got my refurbished PR2 for $180,000. For that, with Stretch I could have 10!”
—Maya Cakmak, University of Washington

Of course, a portable robot doesn’t do you any good if the robot itself isn’t sophisticated enough to do what you need it to do. Stretch is certainly a compromise in functionality in the interest of small size and low cost, but it’s a compromise that’s been carefully thought out, based on the experience that Edsinger has building robots and the experience that Kemp has operating robots in homes. For example, most mobile manipulators are essentially multi-degrees-of-freedom arms on mobile bases. Stretch instead leverages its wheeled base to move its arm in the horizontal plane, which (most of the time) works just as well as an extra DoF or two on the arm while saving substantially on weight and cost. Similarly, Stretch relies almost entirely on one sensor, an Intel RealSense D435i on a pan-tilt head that gives it a huge range of motion. The RealSense serves as a navigation camera, manipulation camera, a 3D mapping system, and more. It’s not going to be quite as good for a task that might involve fine manipulation, but most of the time it’s totally workable and you’re saving on cost and complexity.

Stretch has been relentlessly optimized to be the absolutely minimum robot to do mobile manipulation in a home or workplace environment. In practice, this meant figuring out exactly what it was absolutely necessary for Stretch to be able to do. With an emphasis on manipulation, that meant defining the workspace of the robot, or what areas it’s able to usefully reach. “That was one thing we really had to push hard on,” says Edsinger. “Reachability.” He explains that reachability and a small mobile base tend not to go together, because robot arms (which tend to weigh a lot) can cause a small base to tip, especially if they’re moving while holding a payload. At the same time, Stretch needed to be able to access both countertops and the floor, while being able to reach out far enough to hand people things without having to be right next to them. To come up with something that could meet all those requirements, Edsinger and Kemp set out to reinvent the robot arm.

Stretch’s key innovation: a stretchable arm
The design they came up with is rather ingenious in its simplicity and how well it works. Edsinger explains that the arm consists of five telescoping links: one fixed and four moving. They are constructed of custom carbon fiber, and are driven by a single motor, which is attached to the robot’s vertical pole. The strong, lightweight structure allows the arm to extend over half a meter and hold up to 1.5 kg. Although the company has a patent pending for the design, Edsinger declined to say whether the links are driven by a belt, cables, or gears. “We don’t want to disclose too much of the secret sauce [with regard to] the drive mechanism.” He added that the arm was “one of the most significant engineering challenges on the robot in terms of getting the desired reach, compactness, precision, smoothness, force sensitivity, and low cost to all happily coexist.”

Photo: Hello Robot

Stretch’s arm consists of five telescoping links constructed of custom carbon fiber, and are driven by a single motor, which is attached to the robot’s vertical pole, minimizing weight and inertia. The arm has a reach of over half a meter and can hold up to 1.5 kg.

Another interesting features of Stretch is its interface with the world—its gripper. There are countless different gripper designs out there, each and every one of which is the best at gripping some particular subset of things. But making a generalized gripper for all of the stuff that you’d find in a home is exceptionally difficult. Ideally, you’d want some sort of massive experimental test program where thousands and thousands of people test out different gripper designs in their homes for long periods of time and then tell you which ones work best. Obviously, that’s impractical for a robotics startup, but Kemp realized that someone else was already running the study for him: Amazon.

“I had this idea that there are these assistive grabbers that people with disabilities use to grasp objects in the real world,” he told us. Kemp went on Amazon’s website and looked at the top 10 grabbers and the reviews from thousands of users. He then bought a bunch of different ones and started testing them. “This one [Stretch’s gripper], I almost didn’t order it, it was such a weird looking thing,” he says. “But it had great reviews on Amazon, and oh my gosh, it just blew away the other grabbers. And I was like, that’s it. It just works.”

Stretch’s teleoperated and autonomous capabilities
As with any robot intended to be useful outside of a structured environment, hardware is only part of the story, and arguably not even the most important part. In order for Stretch to be able to operate out from under the supervision of a skilled roboticist, it has to be either easy to control, or autonomous. Ideally, it’s both, and that’s what Hello Robot is working towards, although things didn’t start out that way, Kemp explains. “From a minimalist standpoint, we began with the notion that this would be a teleoperated robot. But in the end, you just don’t get the real power of the robot that way, because you’re tied to a person doing stuff. As much as we fought it, autonomy really is a big part of the future for this kind of system.”

Here’s a look at some of Stretch’s teleoperated capabilities. We’re told that Stretch is very easy to get going right out of the box, although this teleoperation video from Hello Robot looks like it’s got a skilled and experienced user in the loop:

For such a low-cost platform, the autonomy (even at this early stage) is particularly impressive:

Since it’s not entirely clear from the video exactly what’s autonomous, here’s a brief summary of a couple of the more complex behaviors that Kemp sent us:

Object grasping: Stretch uses its 3D camera to find the nearest flat surface using a virtual overhead view. It then segments significant blobs on top of the surface. It selects the largest blob in this virtual overhead view and fits an ellipse to it. It then generates a grasp plan that makes use of the center of the ellipse and the major and minor axes. Once it has a plan, Stretch orients its gripper, moves to the pre-grasp pose, moves to the grasp pose, closes its gripper based on the estimated object width, lifts up, and retracts.
Mapping, navigating, and reaching to a 3D point: These demonstrations all use FUNMAP (Fast Unified Navigation, Manipulation and Planning). It’s all novel custom Python code. Even a single head scan performed by panning the 3D camera around can result in a very nice 3D representation of Stretch’s surroundings that includes the nearby floor. This is surprisingly unusual for robots, which often have their cameras too low to see many interesting things in a human environment. While mapping, Stretch selects where to scan next in a non-trivial way that considers factors such as the quality of previous observations, expected new observations, and navigation distance. The plan that Stretch uses to reach the target 3D point has been optimized for navigation and manipulation. For example, it finds a final robot pose that provides a large manipulation workspace for Stretch, which must consider nearby obstacles, including obstacles on the ground.
Object handover: This is a simple demonstration of object handovers. Stretch performs Cartesian motions to move its gripper to a body-relative position using a good motion heuristic, which is to extend the arm as the last step. These simple motions work well due to the design of Stretch. It still surprises me how well it moves the object to comfortable places near my body, and how unobtrusive it is. The goal point is specified relative to a 3D frame attached to the person’s mouth estimated using deep learning models (shown in the RViz visualization video). Specifically, Stretch targets handoff at a 3D point that is 20 cm below the estimated position of the mouth and 25 cm away along the direction of reaching.

Much of these autonomous capabilities come directly from Kemp’s lab, and the demo code is available for anyone to use. (Hello Robot says all of Stretch’s software is open source.)

Photo: Hello Robot

Hello Robot co-founder and CEO Aaron Edsinger says Stretch is designed to work with people in homes and workplaces and can be teleoperated to do a variety of tasks, including picking up toys, removing laundry from a dryer, and playing games with kids.

As of right now, Stretch is very much a research platform. You’re going to see it in research labs doing research things, and hopefully in homes and commercial spaces as well, but still under the supervision of professional roboticists. As you may have guessed, though, Hello Robot’s vision is a bit broader than that. “The impact we want to have is through robots that are helpful to people in society,” Edsinger says. “We think primarily in the home context, but it could be in healthcare, or in other places. But we really want to have our robots be impactful, and useful. To us, useful is exciting.” Adds Kemp: “I have a personal bias, but we’d really like this technology to benefit older adults and caregivers. Rather than creating a specialized assistive device, we want to eventually create an inexpensive consumer device for everyone that does lots of things.”

Neither Edsinger nor Kemp would say much more on this for now, and they were very explicit about why—they’re being deliberately cautious about raising expectations, having seen what’s happened to some other robotics companies over the past few years. Without VC funding (Hello Robot is currently bootstrapping itself into existence), Stretch is being sold entirely on its own merits. So far, it seems to be working. Stretch robots are already in a half dozen research labs, and we expect that with today’s announcement, we’ll start seeing them much more frequently.

This article appears in the October 2020 print issue as “A Robot That Keeps It Simple.” Continue reading

Posted in Human Robots

#437673 Can AI and Automation Deliver a COVID-19 ...

Illustration: Marysia Machulska

Within moments of meeting each other at a conference last year, Nathan Collins and Yann Gaston-Mathé began devising a plan to work together. Gaston-Mathé runs a startup that applies automated software to the design of new drug candidates. Collins leads a team that uses an automated chemistry platform to synthesize new drug candidates.

“There was an obvious synergy between their technology and ours,” recalls Gaston-Mathé, CEO and cofounder of Paris-based Iktos.

In late 2019, the pair launched a project to create a brand-new antiviral drug that would block a specific protein exploited by influenza viruses. Then the COVID-19 pandemic erupted across the world stage, and Gaston-Mathé and Collins learned that the viral culprit, SARS-CoV-2, relied on a protein that was 97 percent similar to their influenza protein. The partners pivoted.

Their companies are just two of hundreds of biotech firms eager to overhaul the drug-discovery process, often with the aid of artificial intelligence (AI) tools. The first set of antiviral drugs to treat COVID-19 will likely come from sifting through existing drugs. Remdesivir, for example, was originally developed to treat Ebola, and it has been shown to speed the recovery of hospitalized COVID-19 patients. But a drug made for one condition often has side effects and limited potency when applied to another. If researchers can produce an ­antiviral that specifically targets SARS-CoV-2, the drug would likely be safer and more effective than a repurposed drug.

There’s one big problem: Traditional drug discovery is far too slow to react to a pandemic. Designing a drug from scratch typically takes three to five years—and that’s before human clinical trials. “Our goal, with the combination of AI and automation, is to reduce that down to six months or less,” says Collins, who is chief strategy officer at SRI Biosciences, a division of the Silicon Valley research nonprofit SRI International. “We want to get this to be very, very fast.”

That sentiment is shared by small biotech firms and big pharmaceutical companies alike, many of which are now ramping up automated technologies backed by supercomputing power to predict, design, and test new antivirals—for this pandemic as well as the next—with unprecedented speed and scope.

“The entire industry is embracing these tools,” says Kara Carter, president of the International Society for Antiviral Research and executive vice president of infectious disease at Evotec, a drug-discovery company in Hamburg. “Not only do we need [new antivirals] to treat the SARS-CoV-2 infection in the population, which is probably here to stay, but we’ll also need them to treat future agents that arrive.”

There are currentlyabout 200 known viruses that infect humans. Although viruses represent less than 14 percent of all known human pathogens, they make up two-thirds of all new human pathogens discovered since 1980.

Antiviral drugs are fundamentally different from vaccines, which teach a person’s immune system to mount a defense against a viral invader, and antibody treatments, which enhance the body’s immune response. By contrast, anti­virals are chemical compounds that directly block a virus after a person has become infected. They do this by binding to specific proteins and preventing them from functioning, so that the virus cannot copy itself or enter or exit a cell.

The SARS-CoV-2 virus has an estimated 25 to 29 proteins, but not all of them are suitable drug targets. Researchers are investigating, among other targets, the virus’s exterior spike protein, which binds to a receptor on a human cell; two scissorlike enzymes, called proteases, that cut up long strings of viral proteins into functional pieces inside the cell; and a polymerase complex that makes the cell churn out copies of the virus’s genetic material, in the form of single-stranded RNA.

But it’s not enough for a drug candidate to simply attach to a target protein. Chemists also consider how tightly the compound binds to its target, whether it binds to other things as well, how quickly it metabolizes in the body, and so on. A drug candidate may have 10 to 20 such objectives. “Very often those objectives can appear to be anticorrelated or contradictory with each other,” says Gaston-Mathé.

Compared with antibiotics, antiviral drug discovery has proceeded at a snail’s pace. Scientists advanced from isolating the first antibacterial molecules in 1910 to developing an arsenal of powerful antibiotics by 1944. By contrast, it took until 1951 for researchers to be able to routinely grow large amounts of virus particles in cells in a dish, a breakthrough that earned the inventors a Nobel Prize in Medicine in 1954.

And the lag between the discovery of a virus and the creation of a treatment can be heartbreaking. According to the World Health Organization, 71 million people worldwide have chronic hepatitis C, a major cause of liver cancer. The virus that causes the infection was discovered in 1989, but effective antiviral drugs didn’t hit the market until 2014.

While many antibiotics work on a range of microbes, most antivirals are highly specific to a single virus—what those in the business call “one bug, one drug.” It takes a detailed understanding of a virus to develop an antiviral against it, says Che Colpitts, a virologist at Queen’s University, in Canada, who works on antivirals against RNA viruses. “When a new virus emerges, like SARS-CoV-2, we’re at a big disadvantage.”

Making drugs to stop viruses is hard for three main reasons. First, viruses are the Spartans of the pathogen world: They’re frugal, brutal, and expert at evading the human immune system. About 20 to 250 nanometers in diameter, viruses rely on just a few parts to operate, hijacking host cells to reproduce and often destroying those cells upon departure. They employ tricks to camouflage their presence from the host’s immune system, including preventing infected cells from sending out molecular distress beacons. “Viruses are really small, so they only have a few components, so there’s not that many drug targets available to start with,” says Colpitts.

Second, viruses replicate quickly, typically doubling in number in hours or days. This constant copying of their genetic material enables viruses to evolve quickly, producing mutations able to sidestep drug effects. The virus that causes AIDS soon develops resistance when exposed to a single drug. That’s why a cocktail of antiviral drugs is used to treat HIV infection.

Finally, unlike bacteria, which can exist independently outside human cells, viruses invade human cells to propagate, so any drug designed to eliminate a virus needs to spare the host cell. A drug that fails to distinguish between a virus and a cell can cause serious side effects. “Discriminating between the two is really quite difficult,” says Evotec’s Carter, who has worked in antiviral drug discovery for over three decades.

And then there’s the money barrier. Developing antivirals is rarely profitable. Health-policy researchers at the London School of Economics recently estimated that the average cost of developing a new drug is US $1 billion, and up to $2.8 billion for cancer and other specialty drugs. Because antivirals are usually taken for only short periods of time or during short outbreaks of disease, companies rarely recoup what they spent developing the drug, much less turn a profit, says Carter.

To change the status quo, drug discovery needs fresh approaches that leverage new technologies, rather than incremental improvements, says Christian Tidona, managing director of BioMed X, an independent research institute in Heidelberg, Germany. “We need breakthroughs.”

Putting Drug Development on Autopilot
Earlier this year, SRI Biosciences and Iktos began collaborating on a way to use artificial intelligence and automated chemistry to rapidly identify new drugs to target the COVID-19 virus. Within four months, they had designed and synthesized a first round of antiviral candidates. Here’s how they’re doing it.

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STEP 1: Iktos’s AI platform uses deep-learning algorithms in an iterative process to come up with new molecular structures likely to bind to and disable a specific coronavirus protein. Illustrations: Chris Philpot

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STEP 2: SRI Biosciences’s SynFini system is a three-part automated chemistry suite for producing new compounds. Starting with a target compound from Iktos, SynRoute uses machine learning to analyze and optimize routes for creating that compound, with results in about 10 seconds. It prioritizes routes based on cost, likelihood of success, and ease of implementation.

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STEP 3: SynJet, an automated inkjet printer platform, tests the routes by printing out tiny quantities of chemical ingredients to see how they react. If the right compound is produced, the platform tests it.

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STEP 4: AutoSyn, an automated tabletop chemical plant, synthesizes milligrams to grams of the desired compound for further testing. Computer-selected “maps” dictate paths through the plant’s modular components.

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STEP 5: The most promising compounds are tested against live virus samples.

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Iktos’s AI platform was created by a medicinal chemist and an AI expert. To tackle SARS-CoV-2, the company used generative models—deep-learning algorithms that generate new data—to “imagine” molecular structures with a good chance of disabling a key coronavirus protein.

For a new drug target, the software proposes and evaluates roughly 1 million compounds, says Gaston-Mathé. It’s an iterative process: At each step, the system generates 100 virtual compounds, which are tested in silico with predictive models to see how closely they meet the objectives. The test results are then used to design the next batch of compounds. “It’s like we have a very, very fast chemist who is designing compounds, testing compounds, getting back the data, then designing another batch of compounds,” he says.

The computer isn’t as smart as a human chemist, Gaston-Mathé notes, but it’s much faster, so it can explore far more of what people in the field call “chemical space”—the set of all possible organic compounds. Unexplored chemical space is huge: Biochemists estimate that there are at least 1063 possible druglike molecules, and that 99.9 percent of all possible small molecules or compounds have never been synthesized.

Still, designing a chemical compound isn’t the hardest part of creating a new drug. After a drug candidate is designed, it must be synthesized, and the highly manual process for synthesizing a new chemical hasn’t changed much in 200 years. It can take days to plan a synthesis process and then months to years to optimize it for manufacture.

That’s why Gaston-Mathé was eager to send Iktos’s AI-generated designs to Collins’s team at SRI Biosciences. With $13.8 million from the Defense Advanced Research Projects Agency, SRI Biosciences spent the last four years automating the synthesis process. The company’s automated suite of three technologies, called SynFini, can produce new chemical compounds in just hours or days, says Collins.

First, machine-learning software devises possible routes for making a desired molecule. Next, an inkjet printer platform tests the routes by printing out and mixing tiny quantities of chemical ingredients to see how they react with one another; if the right compound is produced, the platform runs tests on it. Finally, a tabletop chemical plant synthesizes milligrams to grams of the desired compound.

Less than four months after Iktos and SRI Biosciences announced their collaboration, they had designed and synthesized a first round of antiviral candidates for SARS-CoV-2. Now they’re testing how well the compounds work on actual samples of the virus.

Out of 10
63 possible druglike molecules, 99.9 percent have never been synthesized.

Theirs isn’t the only collaborationapplying new tools to drug discovery. In late March, Alex Zhavoronkov, CEO of Hong Kong–based Insilico Medicine, came across a YouTube video showing three virtual-reality avatars positioning colorful, sticklike fragments in the side of a bulbous blue protein. The three researchers were using VR to explore how compounds might bind to a SARS-CoV-2 enzyme. Zhavoronkov contacted the startup that created the simulation—Nanome, in San Diego—and invited it to examine Insilico’s ­AI-generated molecules in virtual reality.

Insilico runs an AI platform that uses biological data to train deep-learning algorithms, then uses those algorithms to identify molecules with druglike features that will likely bind to a protein target. A four-day training sprint in late January yielded 100 molecules that appear to bind to an important SARS-CoV-2 protease. The company recently began synthesizing some of those molecules for laboratory testing.

Nanome’s VR software, meanwhile, allows researchers to import a molecular structure, then view and manipulate it on the scale of individual atoms. Like human chess players who use computer programs to explore potential moves, chemists can use VR to predict how to make molecules more druglike, says Nanome CEO Steve McCloskey. “The tighter the interface between the human and the computer, the more information goes both ways,” he says.

Zhavoronkov sent data about several of Insilico’s compounds to Nanome, which re-created them in VR. Nanome’s chemist demonstrated chemical tweaks to potentially improve each compound. “It was a very good experience,” says Zhavoronkov.

Meanwhile, in March, Takeda Pharmaceutical Co., of Japan, invited Schrödinger, a New York–based company that develops chemical-simulation software, to join an alliance working on antivirals. Schrödinger’s AI focuses on the physics of how proteins interact with small molecules and one another.

The software sifts through billions of molecules per week to predict a compound’s properties, and it optimizes for multiple desired properties simultaneously, says Karen Akinsanya, chief biomedical scientist and head of discovery R&D at Schrödinger. “There’s a huge sense of urgency here to come up with a potent molecule, but also to come up with molecules that are going to be well tolerated” by the body, she says. Drug developers are seeking compounds that can be broadly used and easily administered, such as an oral drug rather than an intravenous drug, she adds.

Schrödinger evaluated four protein targets and performed virtual screens for two of them, a computing-intensive process. In June, Google Cloud donated the equivalent of 16 million hours of Nvidia GPU time for the company’s calculations. Next, the alliance’s drug companies will synthesize and test the most promising compounds identified by the virtual screens.

Other companies, including Amazon Web Services, IBM, and Intel, as well as several U.S. national labs are also donating time and resources to the Covid-19 High Performance Computing Consortium. The consortium is supporting 87 projects, which now have access to 6.8 million CPU cores, 50,000 GPUs, and 600 petaflops of computational resources.

While advanced technologies could transform early drug discovery, any new drug candidate still has a long road after that. It must be tested in animals, manufactured in large batches for clinical trials, then tested in a series of trials that, for antivirals, lasts an average of seven years.

In May, the BioMed X Institute in Germany launched a five-year project to build a Rapid Antiviral Response Platform, which would speed drug discovery all the way through manufacturing for clinical trials. The €40 million ($47 million) project, backed by drug companies, will identify ­outside-the-box proposals from young scientists, then provide space and funding to develop their ideas.

“We’ll focus on technologies that allow us to go from identification of a new virus to 10,000 doses of a novel potential therapeutic ready for trials in less than six months,” says BioMed X’s Tidona, who leads the project.

While a vaccine will likely arrive long before a bespoke antiviral does, experts expect COVID-19 to be with us for a long time, so the effort to develop a direct-acting, potent antiviral continues. Plus, having new antivirals—and tools to rapidly create more—can only help us prepare for the next pandemic, whether it comes next month or in another 102 years.

“We’ve got to start thinking differently about how to be more responsive to these kinds of threats,” says Collins. “It’s pushing us out of our comfort zones.”

This article appears in the October 2020 print issue as “Automating Antivirals.” Continue reading

Posted in Human Robots