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#435793 Tiny Robots Carry Stem Cells Through a ...

Posted on September 21, 2019 by Android

Engineers have built microrobots to perform all sorts of tasks in the body, and can now add to that list another key skill: delivering stem cells. In a paper published today in Science Robotics, researchers describe propelling a magnetically-controlled, stem-cell-carrying bot through a live mouse.

Under a rotating magnetic field, the microrobots moved with rolling and corkscrew-style locomotion. The researchers, led by Hongsoo Choi and his team at the Daegu Gyeongbuk Institute of Science & Technology (DGIST), in South Korea, also demonstrated their bot’s moves in slices of mouse brain, in blood vessels isolated from rat brains, and in a multi-organ-on-a chip.

The invention provides an alternative way to deliver stem cells, which are increasingly important in medicine. Such cells can be coaxed into becoming nearly any kind of cell, making them great candidates for treating neurodegenerative disorders such as Alzheimer’s.

But delivering stem cells typically requires an injection with a needle, which lowers the survival rate of the stem cells, and limits their reach in the body. Microrobots, however, have the potential to deliver stem cells to precise, hard-to-reach areas, with less damage to surrounding tissue, and better survival rates, says Jin-young Kim, a principle investigator at DGIST-ETH Microrobotics Research Center, and an author on the paper.

The virtues of microrobots have inspired several research groups to propose and test different designs in simple conditions, such as microfluidic channels and other static environments. A group out of Hong Kong last year described a burr-shaped bot that carried cells through live, transparent zebrafish.

The new research presents a magnetically-actuated microrobot that successfully carried stem cells through a live mouse. In additional experiments, the cells, which had differentiated into brain cells such as astrocytes, oligodendrocytes, and neurons, transferred to microtissues on the multi-organ-on-a-chip. Taken together, the proof-of-concept experiments demonstrate the potential for microrobots to be used in human stem cell therapy, says Kim.

The team fabricated the robots with 3D laser lithography, and designed them in two shapes: spherical and helical. Using a rotating magnetic field, the scientists navigated the spherical-shaped bots with a rolling motion, and the helical bots with a corkscrew motion. These styles of locomotion proved more efficient than that from a simple pulling force, and were more suitable for use in biological fluids, the scientists reported.

The big challenge in navigating microbots in a live animal (or human body) is being able to see them in real time. Imaging with fMRI doesn’t work, because the magnetic fields interfere with the system. “To precisely control microbots in vivo, it is important to actually see them as they move,” the authors wrote in their paper.

That wasn’t possible during experiments in a live mouse, so the researchers had to check the location of the microrobots before and after the experiments using an optical tomography system called IVIS. They also had to resort to using a pulling force with a permanent magnet to navigate the microrobots inside the mouse, due to the limitations of the IVIS system.

Kim says he and his colleagues are developing imaging systems that will enable them to view in real time the locomotion of their microrobots in live animals. Continue reading →

Posted in Human Robots

#435784 Amazon Uses 800 Robots to Run This ...

Posted on September 20, 2019 by Android

At Amazon’s re:MARS conference in Las Vegas today, who else but Amazon is introducing two new robots designed to make its fulfillment centers even more fulfilling. Xanthus (named after a mythological horse that could very briefly talk but let’s not read too much into that) is a completely redesigned drive unit, one of the robotic mobile bases that carries piles of stuff around for humans to pick from. It has a thinner profile, a third of the parts, costs half as much, and can wear different modules on top to perform a much wider variety of tasks than its predecessor.

Pegasus (named after a mythological horse that could fly but let’s not read too much into that either) is also a mobile robot, but much smaller than Xanthus, designed to help the company quickly and accurately sort individual packages. For Amazon, it’s a completely new large-scale robotic system involving tightly coordinated fleets of robots tossing boxes down chutes, and it’s just as fun to watch as it sounds.

Amazon has 800 Pegasus units already deployed at a sorting facility in the United States, adding to their newly updated total of 200,000 robotic drive units worldwide.

If the Pegasus system looks familiar, it’s because other warehouse automation companies have had something that’s at least superficially very similar up and running for years.

Photo: Amazon

Pegasus is one of Amazon’s new warehouse robots, equipped with a conveyor belt on top and used in the company’s sorting facilities.

But the most interesting announcement that Amazon made, kind of low key and right at the end of their re:MARS talk, is that they’re working on ways of making some of their mobile robots actually collaborative, leveraging some of the technology that they acquired from Boulder, Colo.-based warehouse robotics startup Canvas Technology earlier this year:

“With our recent acquisition of Canvas, we expect to be able to combine this drive platform with AI and autonomous mobility capabilities, and for the first time, allow our robots to move outside of our robotic drive fields, and interact collaboratively with our associates to do a number of mobility tasks,” said Brad Porter, VP of robotics at Amazon.

At the moment, Amazon’s robots are physically separated from humans except for one highly structured station where the human only interacts with the robot in one or two very specific ways. We were told a few months ago that Amazon would like to have mobile robots that are able to move things through the areas of fulfillment centers that have people in them, but that they’re (quite rightly) worried about the safety aspects of having robots and humans work around each other. Other companies are already doing this on a smaller scale, and it means developing a reliable safety system that can handle randomly moving humans, environmental changes, and all kinds of other stuff. It’s much more difficult than having a nice, clean, roped-off area to work in where a wayward human would be an exception rather than just another part of the job.

Photo: Canvas Technology

A robot created by Canvas Technology, a Boulder, Colo.-based warehouse robotics startup acquired by Amazon earlier this year.

It now seems like Canvas has provided the secret sauce that Amazon needed to start implementing this level of autonomy. As for what it’s going to look like, our best guess is that Amazon is going to have to do a little bit more than slap some extra sensors onto Xanthus or Pegasus, if for no other reason than the robots will almost certainly need more ground clearance to let them operate away from the reliably flat floors that they’re accustomed to. We’re expecting to see them performing many of the tasks that companies like Fetch Robotics and OTTO Motors are doing already—moving everything from small boxes to large pallets to keep humans from having to waste time walking.

Of course, this all feeds back into what drives Amazon more than anything else: efficiency. And for better or worse, humans are not uniquely good at moving things from place to place, so it’s no surprise that Amazon wants to automate that, too. The good news is that, at least for now, Amazon still needs humans to babysit all those robots.

[ Amazon ] Continue reading →

Posted in Human Robots

#435779 This Robot Ostrich Can Ride Around on ...

Posted on September 20, 2019 by Android

Proponents of legged robots say that they make sense because legs are often required to go where humans go. Proponents of wheeled robots say, “Yeah, that’s great but watch how fast and efficient my robot is, compared to yours.” Some robots try and take advantage of wheels and legs with hybrid designs like whegs or wheeled feet, but a simpler and more versatile solution is to do what humans do, and just take advantage of wheels when you need them.

We’ve seen a few experiments with this. The University of Michigan managed to convince Cassie to ride a Segway, with mostly positive (but occasionally quite negative) results. A Segway, and hoverboard-like systems, can provide wheeled mobility for legged robots over flat terrain, but they can’t handle things like stairs, which is kind of the whole point of having a robot with legs anyway.

Image: UC Berkeley

From left, a Segway, a hovercraft, and hovershoes, with complexity in terms of user control increasing from left to right.

At UC Berkeley’s Hybrid Robotics Lab, led by Koushil Sreenath, researchers have taken things a step further. They are teaching their Cassie bipedal robot (called Cassie Cal) to wheel around on a pair of hovershoes. Hovershoes are like hoverboards that have been chopped in half, resulting in a pair of motorized single-wheel skates. You balance on the skates, and control them by leaning forwards and backwards and left and right, which causes each skate to accelerate or decelerate in an attempt to keep itself upright. It’s not easy to get these things to work, even for a human, but by adding a sensor package to Cassie the UC Berkeley researchers have managed to get it to zip around campus fully autonomously.

Remember, Cassie is operating autonomously here—it’s performing vSLAM (with an Intel RealSense) and doing all of its own computation onboard in real time. Watching it jolt across that cracked sidewalk is particularly impressive, especially considering that it only has pitch control over its ankles and can’t roll its feet to maintain maximum contact with the hovershoes. But you can see the advantage that this particular platform offers to a robot like Cassie, including the ability to handle stairs. Stairs in one direction, anyway.

It’s a testament to the robustness of UC Berkeley’s controller that they were willing to let the robot operate untethered and outside, and it sounds like they’re thinking long-term about how legged robots on wheels would be real-world useful:

Our feedback control and autonomous system allow for swift movement through urban environments to aid in everything from food delivery to security and surveillance to search and rescue missions. This work can also help with transportation in large factories and warehouses.

For more details, we spoke with the UC Berkeley students (Shuxiao Chen, Jonathan Rogers, and Bike Zhang) via email.

IEEE Spectrum: How representative of Cassie’s real-world performance is what we see in the video? What happens when things go wrong?

Cassie’s real-world performance is similar to what we see in the video. Cassie can ride the hovershoes successfully all around the campus. Our current controller allows Cassie to robustly ride the hovershoes and rejects various perturbations. At present, one of the failure modes is when the hovershoe rolls to the side—this happens when it goes sideways down a step or encounters a large obstacle on one side of it, causing it to roll over. Under these circumstances, Cassie doesn’t have sufficient control authority (due to the thin narrow feet) to get the hovershoe back on its wheel.

The Hybrid Robotics Lab has been working on robots that walk over challenging terrain—how do wheeled platforms like hovershoes fit in with that?

Surprisingly, this research is related to our prior work on walking on discrete terrain. While locomotion using legs is efficient when traveling over rough and discrete terrain, wheeled locomotion is more efficient when traveling over flat continuous terrain. Enabling legged robots to ride on various micro-mobility platforms will offer multimodal locomotion capabilities, improving the efficiency of locomotion over various terrains.

Our current research furthers the locomotion ability for bipedal robots over continuous terrains by using a wheeled platform. In the long run, we would like to develop multi-modal locomotion strategies based on our current and prior work to allow legged robots to robustly and efficiently locomote in our daily life.

Photo: UC Berkeley

In their experiments, the UC Berkeley researchers say Cassie proved quite capable of riding the hovershoes over rough and uneven terrain, including going down stairs.

How long did it take to train Cassie to use the hovershoes? Are there any hovershoe skills that Cassie is better at than an average human?

We spent about eight months to develop our whole system, including a controller, a path planner, and a vision system. This involved developing mathematical models of Cassie and the hovershoes, setting up a dynamical simulation, figuring out how to interface and communicate with various sensors and Cassie, and doing several experiments to slowly improve performance. In contrast, a human with a good sense of balance needs a few hours to learn to use the hovershoes. A human who has never used skates or skis will probably need a longer time.

A human can easily turn in place on the hovershoes, while Cassie cannot do this motion currently due to our algorithm requiring a non-zero forward speed in order to turn. However, Cassie is much better at riding the hovershoes over rough and uneven terrain including riding the hovershoes down some stairs!

What would it take to make Cassie faster or more agile on the hovershoes?

While Cassie can currently move at a decent pace on the hovershoes and navigate obstacles, Cassie’s ability to avoid obstacles at rapid speeds is constrained by the sensing, the controller, and the onboard computation. To enable Cassie to dynamically weave around obstacles at high speeds exhibiting agile motions, we need to make progress on different fronts.

We need planners that take into account the entire dynamics of the Cassie-Hovershoe system and rapidly generate dynamically-feasible trajectories; we need controllers that tightly coordinate all the degrees-of-freedom of Cassie to dynamically move while balancing on the hovershoes; we need sensors that are robust to motion-blur artifacts caused due to fast turns; and we need onboard computation that can execute our algorithms at real-time speeds.

What are you working on next?

We are working on enabling more aggressive movements for Cassie on the hovershoes by fully exploiting Cassie’s dynamics. We are working on approaches that enable us to easily go beyond hovershoes to other challenging micro-mobility platforms. We are working on enabling Cassie to step onto and off from wheeled platforms such as hovershoes. We would like to create a future of multi-modal locomotion strategies for legged robots to enable them to efficiently help people in our daily life.

“Feedback Control for Autonomous Riding of Hovershoes by a Cassie Bipedal Robot,” by Shuxiao Chen, Jonathan Rogers, Bike Zhang, and Koushil Sreenath from the Hybrid Robotics Lab at UC Berkeley, has been submitted to IEEE Robotics and Automation Letters with option to be presented at the 2019 IEEE RAS International Conference on Humanoid Robots. Continue reading →

Posted in Human Robots

#435775 Jaco Is a Low-Power Robot Arm That Hooks ...

Posted on September 20, 2019 by Android

We usually think of robots as taking the place of humans in various tasks, but robots of all kinds can also enhance human capabilities. This may be especially true for people with disabilities. And while the Cybathlon competition showed what's possible when cutting-edge research robotics is paired with expert humans, that competition isn't necessarily reflective of the kind of robotics available to most people today.

Kinova Robotics's Jaco arm is an assistive robotic arm designed to be mounted on an electric wheelchair. With six degrees of freedom plus a three-fingered gripper, the lightweight carbon fiber arm is frequently used in research because it's rugged and versatile. But from the start, Kinova created it to add autonomy to the lives of people with mobility constraints.

Earlier this year, Kinova shared the story of Mary Nelson, an 11-year-old girl with spinal muscular atrophy, who uses her Jaco arm to show her horse in competition. Spinal muscular atrophy is a neuromuscular disorder that impairs voluntary muscle movement, including muscles that help with respiration, and Mary depends on a power chair for mobility.

We wanted to learn more about how Kinova designs its Jaco arm, and what that means for folks like Mary, so we spoke with both Kinova and Mary's parents to find out how much of a difference a robot arm can make.

IEEE Spectrum: How did Mary interact with the world before having her arm, and what was involved in the decision to try a robot arm in general? And why then Kinova's arm specifically?

Ryan Nelson: Mary interacts with the world much like you and I do, she just uses different tools to do so. For example, she is 100 percent independent using her computer, iPad, and phone, and she prefers to use a mouse. However, she cannot move a standard mouse, so she connects her wheelchair to each device with Bluetooth to move the mouse pointer/cursor using her wheelchair joystick.

For years, we had a Manfrotto magic arm and super clamp attached to her wheelchair and she used that much like the robotic arm. We could put a baseball bat, paint brush, toys, etc. in the super clamp so that Mary could hold the object and interact as physically able children do. Mary has always wanted to be more independent, so we knew the robotic arm was something she must try. We had seen videos of the Kinova arm on YouTube and on their website, so we reached out to them to get a trial.

Can you tell us about the Jaco arm, and how the process of designing an assistive robot arm is different from the process of designing a conventional robot arm?

Nathaniel Swenson, Director of U.S. Operations — Assistive Technologies at Kinova: Jaco is our flagship robotic arm. Inspired by our CEO's uncle and its namesake, Jacques “Jaco” Forest, it was designed as assistive technology with power wheelchair users in mind.

The primary differences between Jaco and our other robots, such as the new Gen3, which was designed to meet the needs of academic and industry research teams, are speed and power consumption. Other robots such as the Gen3 can move faster and draw slightly more power because they aren't limited by the battery size of power wheelchairs. Depending on the use case, they might not interact directly with a human being in the research setting and can safely move more quickly. Jaco is designed to move at safe speeds and make direct contact with the end user and draw very little power directly from their wheelchair.

The most important consideration in the design process of an assistive robot is the safety of the end user. Jaco users operate their robots through their existing drive controls to assist them in daily activities such as eating, drinking, and opening doors and they don't have to worry about the robot draining their chair's batteries throughout the day. The elegant design that results from meeting the needs of our power chair users has benefited subsequent iterations, [of products] such as the Gen3, as well: Kinova's robots are lightweight, extremely efficient in their power consumption, and safe for direct human-robot interaction. This is not true of conventional industrial robots.

What was the learning process like for Mary? Does she feel like she's mastered the arm, or is it a continuous learning process?

Ryan Nelson: The learning process was super quick for Mary. However, she amazes us every day with the new things that she can do with the arm. Literally within minutes of installing the arm on her chair, Mary had it figured out and was shaking hands with the Kinova rep. The control of the arm is super intuitive and the Kinova reps say that SMA (Spinal Muscular Atrophy) children are perfect users because they are so smart—they pick it up right away. Mary has learned to do many fine motor tasks with the arm, from picking up small objects like a pencil or a ruler, to adjusting her glasses on her face, to doing science experiments.

Photo: The Nelson Family

Mary uses a headset microphone to amplify her voice, and she will use the arm and finger to adjust the microphone in front of her mouth after she is done eating (also a task she mastered quickly with the arm). Additionally, Mary will use the arms to reach down and adjust her feet or leg by grabbing them with the arm and moving them to a more comfortable position. All of these examples are things she never really asked us to do, but something she needed and just did on her own, with the help of the arm.

What is the most common feedback that you get from new users of the arm? How about from experienced users who have been using the arm for a while?

Nathaniel Swenson: New users always tell us how excited they are to see what they can accomplish with their new Jaco. From day one, they are able to do things that they have longed to do without assistance from a caregiver: take a drink of water or coffee, scratch an itch, push the button to open an “accessible” door or elevator, or even feed their baby with a bottle.

The most common feedback I hear from experienced users is that Jaco has changed their life. Our experienced users like Mary are rock stars: everywhere they go, people get excited to see what they'll do next. The difference between a new user and an experienced user could be as little as two weeks. People who operate power wheelchairs every day are already expert drivers and we just add a new “gear” to their chair: robot mode. It's fun to see how quickly new users master the intuitive Jaco control modes.

What changes would you like to see in the next generation of Jaco arm?

Ryan Nelson: Titanium fingers! Make it lift heavier objects, hold heavier items like a baseball bat, machine gun, flame thrower, etc., and Mary literally said this last night: “I wish the arm moved fast enough to play the piano.”

Nathaniel Swenson: I love the idea of titanium fingers! Jaco's fingers are made from a flexible polymer and designed to avoid harm. This allows the fingers to bend or dislocate, rather than break, but it also means they are not as durable as a material like titanium. Increased payload, the ability to manipulate heavier objects, requires increased power consumption. We've struck a careful balance between providing enough strength to accomplish most medically necessary Activities of Daily Living and efficient use of the power chair's batteries.

We take Isaac Asimov's Laws of Robotics pretty seriously. When we start to combine machine guns, flame throwers, and artificial intelligence with robots, I get very nervous!

I wish the arm moved fast enough to play the piano, too! I am also a musician and I share Mary's dream of an assistive robot that would enable her to make music. In the meantime, while we work on that, please enjoy this beautiful violin piece by Manami Ito and her one-of-a-kind violin prosthesis:

To what extent could more autonomy for the arm be helpful for users? What would be involved in implementing that?

Nathaniel Swenson: Artificial intelligence, machine learning, and deep learning will introduce greater autonomy in future iterations of assistive robots. This will enable them to perform more complex tasks that aren't currently possible, and enable them to accomplish routine tasks more quickly and with less input than the current manual control requires.

For assistive robots, implementation of greater autonomy involves a focus on end-user safety and improvements in the robot's awareness of its environment. Autonomous robots that work in close proximity with humans need vision. They must be able to see to avoid collisions and they use haptic feedback to tell the robot how much force is being exerted on objects. All of these technologies exist, but the largest obstacle to bringing them to the assistive technology market is to prove to the health insurance companies who will fund them that they are both safe and medically necessary. Continue reading →

Posted in Human Robots

#435769 The Ultimate Optimization Problem: How ...

Posted on September 20, 2019 by Android

Lucas Joppa thinks big. Even while gazing down into his cup of tea in his modest office on Microsoft’s campus in Redmond, Washington, he seems to see the entire planet bobbing in there like a spherical tea bag.

As Microsoft’s first chief environmental officer, Joppa came up with the company’s AI for Earth program, a five-year effort that’s spending US $50 million on AI-powered solutions to global environmental challenges.

The program is not just about specific deliverables, though. It’s also about mindset, Joppa told IEEE Spectrum in an interview in July. “It’s a plea for people to think about the Earth in the same way they think about the technologies they’re developing,” he says. “You start with an objective. So what’s our objective function for Earth?” (In computer science, an objective function describes the parameter or parameters you are trying to maximize or minimize for optimal results.)

Photo: Microsoft

Lucas Joppa

AI for Earth launched in December 2017, and Joppa’s team has since given grants to more than 400 organizations around the world. In addition to receiving funding, some grantees get help from Microsoft’s data scientists and access to the company’s computing resources.

In a wide-ranging interview about the program, Joppa described his vision of the “ultimate optimization problem”—figuring out which parts of the planet should be used for farming, cities, wilderness reserves, energy production, and so on.

Every square meter of land and water on Earth has an infinite number of possible utility functions. It’s the job of Homo sapiens to describe our overall objective for the Earth. Then it’s the job of computers to produce optimization results that are aligned with the human-defined objective.

I don’t think we’re close at all to being able to do this. I think we’re closer from a technology perspective—being able to run the model—than we are from a social perspective—being able to make decisions about what the objective should be. What do we want to do with the Earth’s surface?

Such questions are increasingly urgent, as climate change has already begun reshaping our planet and our societies. Global sea and air surface temperatures have already risen by an average of 1 degree Celsius above preindustrial levels, according to the Intergovernmental Panel on Climate Change.

Today, people all around the world participated in a “climate strike,” with young people leading the charge and demanding a global transition to renewable energy. On Monday, world leaders will gather in New York for the United Nations Climate Action Summit, where they’re expected to present plans to limit warming to 1.5 degrees Celsius.

Joppa says such summit discussions should aim for a truly holistic solution.

We talk about how to solve climate change. There’s a higher-order question for society: What climate do we want? What output from nature do we want and desire? If we could agree on those things, we could put systems in place for optimizing our environment accordingly. Instead we have this scattered approach, where we try for local optimization. But the sum of local optimizations is never a global optimization.

There’s increasing interest in using artificial intelligence to tackle global environmental problems. New sensing technologies enable scientists to collect unprecedented amounts of data about the planet and its denizens, and AI tools are becoming vital for interpreting all that data.

The 2018 report “Harnessing AI for the Earth,” produced by the World Economic Forum and the consulting company PwC, discusses ways that AI can be used to address six of the world’s most pressing environmental challenges (climate change, biodiversity, and healthy oceans, water security, clean air, and disaster resilience).

Many of the proposed applications involve better monitoring of human and natural systems, as well as modeling applications that would enable better predictions and more efficient use of natural resources.

Joppa says that AI for Earth is taking a two-pronged approach, funding efforts to collect and interpret vast amounts of data alongside efforts that use that data to help humans make better decisions. And that’s where the global optimization engine would really come in handy.

For any location on earth, you should be able to go and ask: What’s there, how much is there, and how is it changing? And more importantly: What should be there?

On land, the data is really only interesting for the first few hundred feet. Whereas in the ocean, the depth dimension is really important.

We need a planet with sensors, with roving agents, with remote sensing. Otherwise our decisions aren’t going to be any good.

AI for Earth isn’t going to create such an online portal within five years, Joppa stresses. But he hopes the projects that he’s funding will contribute to making such a portal possible—eventually.

We’re asking ourselves: What are the fundamental missing layers in the tech stack that would allow people to build a global optimization engine? Some of them are clear, some are still opaque to me.

By the end of five years, I’d like to have identified these missing layers, and have at least one example of each of the components.

Some of the projects that AI for Earth has funded seem to fit that desire. Examples include SilviaTerra, which used satellite imagery and AI to create a map of the 92 billion trees in forested areas across the United States. There’s also OceanMind, a non-profit that detects illegal fishing and helps marine authorities enforce compliance. Platforms like Wildbook and iNaturalist enable citizen scientists to upload pictures of animals and plants, aiding conservation efforts and research on biodiversity. And FarmBeats aims to enable data-driven agriculture with low-cost sensors, drones, and cloud services.

It’s not impossible to imagine putting such services together into an optimization engine that knows everything about the land, the water, and the creatures who live on planet Earth. Then we’ll just have to tell that engine what we want to do about it.

Editor’s note: This story is published in cooperation with more than 250 media organizations and independent journalists that have focused their coverage on climate change ahead of the UN Climate Action Summit. IEEE Spectrum’s participation in the Covering Climate Now partnership builds on our past reporting about this global issue. Continue reading →

Posted in Human Robots