Tag Archives: season

#435773 Video Friday: Roller-Skating Quadruped ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

IEEE Africon 2019 – September 25-27, 2019 – Accra, Ghana
RoboBusiness 2019 – October 1-3, 2019 – Santa Clara, CA, USA
ISRR 2019 – October 6-10, 2019 – Hanoi, Vietnam
Ro-Man 2019 – October 14-18, 2019 – New Delhi, India
Humanoids 2019 – October 15-17, 2019 – Toronto, Canada
ARSO 2019 – October 31-1, 2019 – Beijing, China
ROSCon 2019 – October 31-1, 2019 – Macau
IROS 2019 – November 4-8, 2019 – Macau
Let us know if you have suggestions for next week, and enjoy today's videos.

We got a sneak peek of a new version of ANYmal equipped with actuated wheels for feet at the DARPA SubT Challenge, where it did surprisingly well at quickly and (mostly) robustly navigating some very tricky terrain. And when you're not expecting it to travel through a muddy, rocky, and dark tunnel, it looks even more capable:

[ Paper ]

Thanks Marko!

In Langley’s makerspace lab, researchers are developing a series of soft robot actuators to investigate the viability of soft robotics in space exploration and assembly. By design, the actuator has chambers, or air bladders, that expand and compress based on the amount of air in them.

[ NASA ]

I’m not normally a fan of the AdultSize RoboCup soccer competition, but NimbRo had a very impressive season.

I don’t know how it managed to not fall over at 45 seconds, but damn.

[ NimbRo ]

This is more AI than robotics, but that’s okay, because it’s totally cool.

I’m wondering whether the hiders ever tried another possibly effective strategy: trapping the seekers in a locked shelter right at the start.

[ OpenAI ]

We haven’t heard much from Piaggio Fast Forward in a while, but evidently they’ve still got a Gita robot going on, designed to be your personal autonomous caddy for absolutely anything that can fit into something the size of a portable cooler.

Available this fall, I guess?

[ Gita ]

This passively triggered robotic hand is startlingly fast, and seems almost predatory when it grabs stuff, especially once they fit it onto a drone.

[ New Dexterity ]

Thanks Fan!

Autonomous vehicles seem like a recent thing, but CMU has been working on them since the mid 1980s.

CMU was also working on drones back before drones were even really a thing:

[ CMU NavLab ] and [ CMU ]

Welcome to the most complicated and expensive robotic ice cream deployment system ever created.

[ Niska ]

Some impressive dexterity from a robot hand equipped with magnetic gears.

[ Ishikawa Senoo Lab ]

The Buddy Arduino social robot kit is now live on Kickstarter, and you can pledge for one of these little dudes for 49 bucks.

[ Kickstarter ]

Thanks Jenny!

Mobile manipulation robots have high potential to support rescue forces in disaster-response missions. Despite the difficulties imposed by real-world scenarios, robots are promising to perform mission tasks from a safe distance. In the CENTAURO project, we developed a disaster-response system which consists of the highly flexible Centauro robot and suitable control interfaces including an immersive telepresence suit and support-operator controls on different levels of autonomy.

[ CENTAURO ]

Thanks Sven!

Determined robots are the cutest robots.

[ Paper ]

The goal of the Dronument project is to create an aerial platform enabling interior and exterior documentation of heritage sites.

It’s got a base station that helps with localization, but still, flying that close to a chandelier in a UNESCO world heritage site makes me nervous.

[ Dronument ]

Thanks Fan!

Avast ye! No hornswaggling, lick-spittlering, or run-rigging over here – Only serious tech for devs. All hands hoay to check out Misty's capabilities and to build your own skills with plenty of heave ho! ARRRRRRRRGH…

International Talk Like a Pirate Day was yesterday, but I'm sure nobody will look at you funny if you keep at it today too.

[ Misty Robotics ]

This video presents an unobtrusive bimanual teleoperation setup with very low weight, consisting of two Vive visual motion trackers and two Myo surface electromyography bracelets. The video demonstrates complex, dexterous teleoperated bimanual daily-living tasks performed by the torque-controlled humanoid robot TORO.

[ DLR RMC ]

Lex Fridman interviews iRobot’s Colin Angle on the Artificial Intelligence Podcast.

Colin Angle is the CEO and co-founder of iRobot, a robotics company that for 29 years has been creating robots that operate successfully in the real world, not as a demo or on a scale of dozens, but on a scale of thousands and millions. As of this year, iRobot has sold more than 25 million robots to consumers, including the Roomba vacuum cleaning robot, the Braava floor mopping robot, and soon the Terra lawn mowing robot. 25 million robots successfully operating autonomously in people's homes to me is an incredible accomplishment of science, engineering, logistics, and all kinds of entrepreneurial innovation.

[ AI Podcast ]

This week’s CMU RI Seminar comes from CMU’s own Sarah Bergbreiter, on Microsystems-Inspired Robotics.

The ability to manufacture micro-scale sensors and actuators has inspired the robotics community for over 30 years. There have been huge success stories; MEMS inertial sensors have enabled an entire market of low-cost, small UAVs. However, the promise of ant-scale robots has largely failed. Ants can move high speeds on surfaces from picnic tables to front lawns, but the few legged microrobots that have walked have done so at slow speeds (< 1 body length/sec) on smooth silicon wafers. In addition, the vision of large numbers of microfabricated sensors interacting directly with the environment has suffered in part due to the brittle materials used in micro-fabrication. This talk will present our progress in the design of sensors, mechanisms, and actuators that utilize new microfabrication processes to incorporate materials with widely varying moduli and functionality to achieve more robustness, dynamic range, and complexity in smaller packages.

[ CMU RI ] Continue reading

Posted in Human Robots

#435757 Robotic Animal Agility

An off-shore wind power platform, somewhere in the North Sea, on a freezing cold night, with howling winds and waves crashing against the impressive structure. An imperturbable ANYmal is quietly conducting its inspection.

ANYmal, a medium sized dog-like quadruped robot, walks down the stairs, lifts a “paw” to open doors or to call the elevator and trots along corridors. Darkness is no problem: it knows the place perfectly, having 3D-mapped it. Its laser sensors keep it informed about its precise path, location and potential obstacles. It conducts its inspection across several rooms. Its cameras zoom in on counters, recording the measurements displayed. Its thermal sensors record the temperature of machines and equipment and its ultrasound microphone checks for potential gas leaks. The robot also inspects lever positions as well as the correct positioning of regulatory fire extinguishers. As the electronic buzz of its engines resumes, it carries on working tirelessly.

After a little over two hours of inspection, the robot returns to its docking station for recharging. It will soon head back out to conduct its next solitary patrol. ANYmal played alongside Mulder and Scully in the “X-Files” TV series*, but it is in no way a Hollywood robot. It genuinely exists and surveillance missions are part of its very near future.

Off-shore oil platforms, the first test fields and probably the first actual application of ANYmal. ©ANYbotics

This quadruped robot was designed by ANYbotics, a spinoff of the Swiss Federal Institute of Technology in Zurich (ETH Zurich). Made of carbon fibre and aluminium, it weighs about thirty kilos. It is fully ruggedised, water- and dust-proof (IP-67). A kevlar belly protects its main body, carrying its powerful brain, batteries, network device, power management system and navigational systems.

ANYmal was designed for all types of terrain, including rubble, sand or snow. It has been field tested on industrial sites and is at ease with new obstacles to overcome (and it can even get up after a fall). Depending on its mission, its batteries last 2 to 4 hours.

On its jointed legs, protected by rubber pads, it can walk (at the speed of human steps), trot, climb, curl upon itself to crawl, carry a load or even jump and dance. It is the need to move on all surfaces that has driven its designers to choose a quadruped. “Biped robots are not easy to stabilise, especially on irregular terrain” explains Dr Péter Fankhauser, co-founder and chief business development officer of ANYbotics. “Wheeled or tracked robots can carry heavy loads, but they are bulky and less agile. Flying drones are highly mobile, but cannot carry load, handle objects or operate in bad weather conditions. We believe that quadrupeds combine the optimal characteristics, both in terms of mobility and versatility.”

What served as a source of inspiration for the team behind the project, the Robotic Systems Lab of the ETH Zurich, is a champion of agility on rugged terrain: the mountain goat. “We are of course still a long way” says Fankhauser. “However, it remains our objective on the longer term.

The first prototype, ALoF, was designed already back in 2009. It was still rather slow, very rigid and clumsy – more of a proof of concept than a robot ready for application. In 2012, StarlETH, fitted with spring joints, could hop, jump and climb. It was with this robot that the team started participating in 2014 in ARGOS, a full-scale challenge, launched by the Total oil group. The idea was to present a robot capable of inspecting an off-shore drilling station autonomously.

Up against dozens of competitors, the ETH Zurich team was the only team to enter the competition with such a quadrupedal robot. They didn’t win, but the multiple field tests were growing evermore convincing. Especially because, during the challenge, the team designed new joints with elastic actuators made in-house. These joints, inspired by tendons and muscles, are compact, sealed and include their own custom control electronics. They can regulate joint torque, position and impedance directly. Thanks to this innovation, the team could enter the same competition with a new version of its robot, ANYmal, fitted with three joints on each leg.

The ARGOS experience confirms the relevance of the selected means of locomotion. “Our robot is lighter, takes up less space on site and it is less noisy” says Fankhauser. “It also overcomes bigger obstacles than larger wheeled or tracked robots!” As ANYmal generated public interest and its transformation into a genuine product seemed more than possible, the startup ANYbotics was launched in 2016. It sold not only its robot, but also its revolutionary joints, called ANYdrive.

Today, ANYmal is not yet ready for sale to companies. However, ANYbotics has a growing number of partnerships with several industries, testing the robot for a few days or several weeks, for all types of tasks. Last October, for example, ANYmal navigated its way through the dark sewage system of the city of Zurich in order to test its capacity to help workers in similar difficult, repetitive and even dangerous tasks.

Why such an early interest among companies? “Because many companies want to integrate robots into their maintenance tasks” answers Fankhauser. “With ANYmal, they can actually evaluate its feasibility and plan their strategy. Eventually, both the architecture and the equipment of buildings could be rethought to be adapted to these maintenance robots”.

ANYmal requires ruggedised, sealed and extremely reliable interconnection solutions, such as LEMO. ©ANYbotics

Through field demonstrations and testing, ANYbotics can gather masses of information (up to 50,000 measurements are recorded every second during each test!) “It helps us to shape the product.” In due time, the startup will be ready to deliver a commercial product which really caters for companies’ needs.

Inspection and surveillance tasks on industrial sites are not the only applications considered. The startup is also thinking of agricultural inspections – with its onboard sensors, ANYmal is capable of mapping its environment, measuring bio mass and even taking soil samples. In the longer term, it could also be used for search and rescue operations. By the way, the robot can already be switched to “remote control” mode at any time and can be easily tele-operated. It is also capable of live audio and video transmission.

The transition from the prototype to the marketed product stage will involve a number of further developments. These include increasing ANYmal’s agility and speed, extending its capacity to map large-scale environments, improving safety, security, user handling and integrating the system with the customer’s data management software. It will also be necessary to enhance the robot’s reliability “so that it can work for days, weeks, or even months without human supervision.” All required certifications will have to be obtained. The locomotion system, which had triggered the whole business, is only one of a number of considerations of ANYbotics.

Designed for extreme environments, for ANYmal smoke is not a problem and it can walk in the snow, through rubble or in water. ©ANYbotics

The startup is not all alone. In fact, it has sold ANYmal robots to a dozen major universities who use them to develop their know-how in robotics. The startup has also founded ANYmal Research, a community including members such as Toyota Research Institute, the German Aerospace Center and the computer company Nvidia. Members have full access to ANYmal’s control software, simulations and documentation. Sharing has boosted both software and hardware ideas and developments (built on ROS, the open-source Robot Operating System). In particular, payload variations, providing for expandability and scalability. For instance, one of the universities uses a robotic arm which enables ANYmal to grasp or handle objects and open doors.

Among possible applications, ANYbotics mentions entertainment. It is not only about playing in more films or TV series, but rather about participating in various attractions (trade shows, museums, etc.). “ANYmal is so novel that it attracts a great amount of interest” confirms Fankhauser with a smile. “Whenever we present it somewhere, people gather around.”

Videos of these events show a fascinated and sometimes slightly fearful audience, when ANYmal gets too close to them. Is it fear of the “bad robot”? “This fear exists indeed and we are happy to be able to use ANYmal also to promote public awareness towards robotics and robots.” Reminiscent of a young dog, ANYmal is truly adapted for the purpose.

However, Péter Fankhauser softens the image of humans and sophisticated robots living together. “These coming years, robots will continue to work in the background, like they have for a long time in factories. Then, they will be used in public places in a selective and targeted way, for instance for dangerous missions. We will need to wait another ten years before animal-like robots, such as ANYmal will share our everyday lives!”

At the Consumer Electronics Show (CES) in Las Vegas in January, Continental, the German automotive manufacturing company, used robots to demonstrate a last-mile delivery. It showed ANYmal getting out of an autonomous vehicle with a parcel, climbing onto the front porch, lifting a paw to ring the doorbell, depositing the parcel before getting back into the vehicle. This futuristic image seems very close indeed.

*X-Files, season 11, episode 7, aired in February 2018 Continue reading

Posted in Human Robots

#435626 Video Friday: Watch Robots Make a Crepe ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. Every week, we also post a calendar of upcoming robotics events; here's what we have so far (send us your events!):

Robotronica – August 18, 2019 – Brisbane, Australia
CLAWAR 2019 – August 26-28, 2019 – Kuala Lumpur, Malaysia
IEEE Africon 2019 – September 25-27, 2019 – Accra, Ghana
ISRR 2019 – October 6-10, 2019 – Hanoi, Vietnam
Ro-Man 2019 – October 14-18, 2019 – New Delhi
Humanoids 2019 – October 15-17, 2019 – Toronto
ARSO 2019 – October 31-November 2, 2019 – Beijing
ROSCon 2019 – October 31-November 1, 2019 – Macau
IROS 2019 – November 4-8, 2019 – Macau
Let us know if you have suggestions for next week, and enjoy today's videos.

Team CoSTAR (JPL, MIT, Caltech, KAIST, LTU) has one of the more diverse teams of robots that we’ve seen:

[ Team CoSTAR ]

A team from Carnegie Mellon University and Oregon State University is sending ground and aerial autonomous robots into a Pittsburgh-area mine to prepare for this month’s DARPA Subterranean Challenge.

“Look at that fire extinguisher, what a beauty!” Expect to hear a lot more of that kind of weirdness during SubT.

[ CMU ]

Unitree Robotics is starting to batch-manufacture Laikago Pro quadrupeds, and if you buy four of them, they can carry you around in a chair!

I’m also really liking these videos from companies that are like, “We have a whole bunch of robot dogs now—what weird stuff can we do with them?”

[ Unitree Robotics ]

Why take a handful of pills every day for all the stuff that's wrong with you, when you could take one custom pill instead? Because custom pills are time-consuming to make, that’s why. But robots don’t care!

Multiply Labs’ factory is designed to operate in parallel. All the filling robots and all the quality-control robots are operating at the same time. The robotic arm, in the meanwhile, shuttles dozens of trays up and down the production floor, making sure that each capsule is filled with the right drugs. The manufacturing cell shown in this article can produce 10,000 personalized capsules in an 8-hour shift. A single cell occupies just 128 square feet (12 square meters) on the production floor. This means that a regular production facility (~10,000 square feet, or 929 m2 ) can house 78 cells, for an overall output of 780,000 capsules per shift. This exceeds the output of most traditional manufacturers—while producing unique personalized capsules!

[ Multiply Labs ]

Thanks Fred!

If you’re getting tired of all those annoying drones that sound like giant bees, just have a listen to this turbine-powered one:

[ Malloy Aeronautics ]

In retrospect, it’s kind of amazing that nobody has bothered to put a functional robotic dog head on a quadruped robot before this, right?

Equipped with sensors, high-tech radar imaging, cameras and a directional microphone, this 100-pound (45-kilogram) super-robot is still a “puppy-in-training.” Just like a regular dog, he responds to commands such as “sit,” “stand,” and “lie down.” Eventually, he will be able to understand and respond to hand signals, detect different colors, comprehend many languages, coordinate his efforts with drones, distinguish human faces, and even recognize other dogs.

As an information scout, Astro’s key missions will include detecting guns, explosives and gun residue to assist police, the military, and security personnel. This robodog’s talents won’t just end there, he also can be programmed to assist as a service dog for the visually impaired or to provide medical diagnostic monitoring. The MPCR team also is training Astro to serve as a first responder for search-and-rescue missions such as hurricane reconnaissance as well as military maneuvers.

[ FAU ]

And now this amazing video, “The Coke Thief,” from ICRA 2005 (!):

[ Paper ]

CYBATHLON Series put the focus on one or two of the six disciplines and are organized in cooperation with international universities and partners. The CYBATHLON Arm and Leg Prosthesis Series took place in Karlsruhe, Germany, from 16 to 18 May and was organized in cooperation with the Karlsruhe Institute of Technology (KIT) and the trade fair REHAB Karlsruhe.

The CYBATHLON Wheelchair Series took place in Kawasaki, Japan on 5 May 2019 and was organized in cooperation with the CYBATHLON Wheelchair Series Japan Organizing Committee and supported by the Swiss Embassy.

[ Cybathlon ]

Rainbow crepe robot!

There’s also this other robot, which I assume does something besides what's in the video, because otherwise it appears to be a massively overengineered way of shaping cooked rice into a chubby triangle.

[ PC Watch ]

The Weaponized Plastic Fighting League at Fetch Robotics has had another season of shardation, deintegration, explodification, and other -tions. Here are a couple fan favorite match videos:

[ Fetch Robotics ]

This video is in German, but it’s worth watching for the three seconds of extremely satisfying footage showing a robot twisting dough into pretzels.

[ Festo ]

Putting brains into farming equipment is a no-brainer, since it’s a semi-structured environment that's generally clear of wayward humans driving other vehicles.

[ Lovol ]

Thanks Fan!

Watch some robots assemble suspiciously Lego-like (but definitely not actually Lego) minifigs.

[ DevLinks ]

The Robotics Innovation Facility (RIFBristol) helps businesses, entrepreneurs, researchers and public sector bodies to embrace the concept of ‘Industry 4.0'. From training your staff in robotics, and demonstrating how automation can improve your manufacturing processes, to prototyping and validating your new innovations—we can provide the support you need.

[ RIF ]

Ryan Gariepy from Clearpath Robotics (and a bunch of other stuff) gave a talk at ICRA with the title of “Move Fast and (Don’t) Break Things: Commercializing Robotics at the Speed of Venture Capital,” which is more interesting when you know that this year’s theme was “Notable Failures.”

[ Clearpath Robotics ]

In this week’s episode of Robots in Depth, Per interviews Michael Nielsen, a computer vision researcher at the Danish Technological Institute.

Michael worked with a fusion of sensors like stereo vision, thermography, radar, lidar and high-frame-rate cameras, merging multiple images for high dynamic range. All this, to be able to navigate the tricky situation in a farm field where you need to navigate close to or even in what is grown. Multibaseline cameras were also used to provide range detection over a wide range of distances.

We also learn about how he expanded his work into sorting recycling, a very challenging problem. We also hear about the problems faced when using time of flight and sheet of light cameras. He then shares some good results using stereo vision, especially combined with blue light random dot projectors.

[ Robots in Depth ] Continue reading

Posted in Human Robots

#435196 Avatar Love? New ‘Black Mirror’ ...

This week, the widely-anticipated fifth season of the dystopian series Black Mirror was released on Netflix. The storylines this season are less focused on far-out scenarios and increasingly aligned with current issues. With only three episodes, this season raises more questions than it answers, often leaving audiences bewildered.

The episode Smithereens explores our society’s crippling addiction to social media platforms and the monopoly they hold over our data. In Rachel, Jack and Ashley Too, we see the disruptive impact of technologies on the music and entertainment industry, and the price of fame for artists in the digital world. Like most Black Mirror episodes, these explore the sometimes disturbing implications of tech advancements on humanity.

But once again, in the midst of all the doom and gloom, the creators of the series leave us with a glimmer of hope. Aligned with Pride month, the episode Striking Vipers explores the impact of virtual reality on love, relationships, and sexual fluidity.

*The review contains a few spoilers.*

Striking Vipers
The first episode of the season, Striking Vipers may be one of the most thought-provoking episodes in Black Mirror history. Reminiscent of previous episodes San Junipero and Hang the DJ, the writers explore the potential for technology to transform human intimacy.

The episode tells the story of two old friends, Danny and Karl, whose friendship is reignited in an unconventional way. Karl unexpectedly appears at Danny’s 38th birthday and reintroduces him to the VR version of a game they used to play years before. In the game Striking Vipers X, each of the players is represented by an avatar of their choice in an uncanny digital reality. Following old tradition, Karl chooses to become the female fighter, Roxanne, and Danny takes on the role of the male fighter, Lance. The state-of-the-art VR headsets appear to use an advanced form of brain-machine interface to allow each player to be fully immersed in the virtual world, emulating all physical sensations.

To their surprise (and confusion), Danny and Karl find themselves transitioning from fist-fighting to kissing. Over the course of many games, they continue to explore a sexual and romantic relationship in the virtual world, leaving them confused and distant in the real world. The virtual and physical realities begin to blur, and so do the identities of the players with their avatars. Danny, who is married (in a heterosexual relationship) and is a father, begins to carry guilt and confusion in the real world. They both wonder if there would be any spark between them in real life.

The brain-machine interface (BMI) depicted in the episode is still science fiction, but that hasn’t stopped innovators from pushing the technology forward. Experts today are designing more intricate BMI systems while programming better algorithms to interpret the neural signals they capture. Scientists have already succeeded in enabling paralyzed patients to type with their minds, and are even allowing people to communicate with one another purely through brainwaves.

The convergence of BMIs with virtual reality and artificial intelligence could make the experience of such immersive digital realities possible. Virtual reality, too, is decreasing exponentially in cost and increasing in quality.

The narrative provides meaningful commentary on another tech area—gaming. It highlights video games not necessarily as addictive distractions, but rather as a platform for connecting with others in a deeper way. This is already very relevant. Video games like Final Fantasy are often a tool for meaningful digital connections for their players.

The Implications of Virtual Reality on Love and Relationships
The narrative of Striking Vipers raises many novel questions about the implications of immersive technologies on relationships: could the virtual world allow us a safe space to explore suppressed desires? Can virtual avatars make it easier for us to show affection to those we care about? Can a sexual or romantic encounter in the digital world be considered infidelity?

Above all, the episode explores the therapeutic possibilities of such technologies. While many fears about virtual reality had been raised in previous seasons of Black Mirror, this episode was focused on its potential. This includes the potential of immersive technology to be a source of liberation, meaningful connections, and self-exploration, as well as a tool for realizing our true identities and desires.

Once again, this is aligned with emerging trends in VR. We are seeing the rise of social VR applications and platforms that allow you to hang out with your friends and family as avatars in the virtual space. The technology is allowing for animation movies, such as Coco VR, to become an increasingly social and interactive experience. Considering that meaningful social interaction can alleviate depression and anxiety, such applications could contribute to well-being.

Techno-philosopher and National Geographic host Jason Silva points out that immersive media technologies can be “engines of empathy.” VR allows us to enter virtual spaces that mimic someone else’s state of mind, allowing us to empathize with the way they view the world. Silva said, “Imagine the intimacy that becomes possible when people meet and they say, ‘Hey, do you want to come visit my world? Do you want to see what it’s like to be inside my head?’”

What is most fascinating about Striking Vipers is that it explores how we may redefine love with virtual reality; we are introduced to love between virtual avatars. While this kind of love may seem confusing to audiences, it may be one of the complex implications of virtual reality on human relationships.

In many ways, the title Black Mirror couldn’t be more appropriate, as each episode serves as a mirror to the most disturbing aspects of our psyches as they get amplified through technology. However, what we see in uplifting and thought-provoking plots like Striking Vipers, San Junipero, and Hang The DJ is that technology could also amplify the most positive aspects of our humanity. This includes our powerful capacity to love.

Image Credit: Arsgera / Shutterstock.com Continue reading

Posted in Human Robots

#434792 Extending Human Longevity With ...

Lizards can regrow entire limbs. Flatworms, starfish, and sea cucumbers regrow entire bodies. Sharks constantly replace lost teeth, often growing over 20,000 teeth throughout their lifetimes. How can we translate these near-superpowers to humans?

The answer: through the cutting-edge innovations of regenerative medicine.

While big data and artificial intelligence transform how we practice medicine and invent new treatments, regenerative medicine is about replenishing, replacing, and rejuvenating our physical bodies.

In Part 5 of this blog series on Longevity and Vitality, I detail three of the regenerative technologies working together to fully augment our vital human organs.

Replenish: Stem cells, the regenerative engine of the body
Replace: Organ regeneration and bioprinting
Rejuvenate: Young blood and parabiosis

Let’s dive in.

Replenish: Stem Cells – The Regenerative Engine of the Body
Stem cells are undifferentiated cells that can transform into specialized cells such as heart, neurons, liver, lung, skin and so on, and can also divide to produce more stem cells.

In a child or young adult, these stem cells are in large supply, acting as a built-in repair system. They are often summoned to the site of damage or inflammation to repair and restore normal function.

But as we age, our supply of stem cells begins to diminish as much as 100- to 10,000-fold in different tissues and organs. In addition, stem cells undergo genetic mutations, which reduce their quality and effectiveness at renovating and repairing your body.

Imagine your stem cells as a team of repairmen in your newly constructed mansion. When the mansion is new and the repairmen are young, they can fix everything perfectly. But as the repairmen age and reduce in number, your mansion eventually goes into disrepair and finally crumbles.

What if you could restore and rejuvenate your stem cell population?

One option to accomplish this restoration and rejuvenation is to extract and concentrate your own autologous adult stem cells from places like your adipose (or fat) tissue or bone marrow.

These stem cells, however, are fewer in number and have undergone mutations (depending on your age) from their original ‘software code.’ Many scientists and physicians now prefer an alternative source, obtaining stem cells from the placenta or umbilical cord, the leftovers of birth.

These stem cells, available in large supply and expressing the undamaged software of a newborn, can be injected into joints or administered intravenously to rejuvenate and revitalize.

Think of these stem cells as chemical factories generating vital growth factors that can help to reduce inflammation, fight autoimmune disease, increase muscle mass, repair joints, and even revitalize skin and grow hair.

Over the last decade, the number of publications per year on stem cell-related research has increased 40x, and the stem cell market is expected to increase to $297 billion by 2022.

Rising research and development initiatives to develop therapeutic options for chronic diseases and growing demand for regenerative treatment options are the most significant drivers of this budding industry.

Biologists led by Kohji Nishida at Osaka University in Japan have discovered a new way to nurture and grow the tissues that make up the human eyeball. The scientists are able to grow retinas, corneas, the eye’s lens, and more, using only a small sample of adult skin.

In a Stanford study, seven of 18 stroke victims who agreed to stem cell treatments showed remarkable motor function improvements. This treatment could work for other neurodegenerative conditions such as Alzheimer’s, Parkinson’s, and ALS.

Doctors from the USC Neurorestoration Center and Keck Medicine of USC injected stem cells into the damaged cervical spine of a recently paralyzed 21-year-old man. Three months later, he showed dramatic improvement in sensation and movement of both arms.

In 2019, doctors in the U.K. cured a patient with HIV for the second time ever thanks to the efficacy of stem cells. After giving the cancer patient (who also had HIV) an allogeneic haematopoietic (e.g. blood) stem cell treatment for his Hodgkin’s lymphoma, the patient went into long-term HIV remission—18 months and counting at the time of the study’s publication.

Replace: Organ Regeneration and 3D Printing
Every 10 minutes, someone is added to the US organ transplant waiting list, totaling over 113,000 people waiting for replacement organs as of January 2019.

Countless more people in need of ‘spare parts’ never make it onto the waiting list. And on average, 20 people die each day while waiting for a transplant.

As a result, 35 percent of all US deaths (~900,000 people) could be prevented or delayed with access to organ replacements.

The excessive demand for donated organs will only intensify as technologies like self-driving cars make the world safer, given that many organ donors result from auto and motorcycle accidents. Safer vehicles mean less accidents and donations.

Clearly, replacement and regenerative medicine represent a massive opportunity.

Organ Entrepreneurs
Enter United Therapeutics CEO, Dr. Martine Rothblatt. A one-time aerospace entrepreneur (she was the founder of Sirius Satellite Radio), Rothblatt changed careers in the 1990s after her daughter developed a rare lung disease.

Her moonshot today is to create an industry of replacement organs. With an initial focus on diseases of the lung, Rothblatt set out to create replacement lungs. To accomplish this goal, her company United Therapeutics has pursued a number of technologies in parallel.

3D Printing Lungs
In 2017, United teamed up with one of the world’s largest 3D printing companies, 3D Systems, to build a collagen bioprinter and is paying another company, 3Scan, to slice up lungs and create detailed maps of their interior.

This 3D Systems bioprinter now operates according to a method called stereolithography. A UV laser flickers through a shallow pool of collagen doped with photosensitive molecules. Wherever the laser lingers, the collagen cures and becomes solid.

Gradually, the object being printed is lowered and new layers are added. The printer can currently lay down collagen at a resolution of around 20 micrometers, but will need to achieve resolution of a micrometer in size to make the lung functional.

Once a collagen lung scaffold has been printed, the next step is to infuse it with human cells, a process called recellularization.

The goal here is to use stem cells that grow on scaffolding and differentiate, ultimately providing the proper functionality. Early evidence indicates this approach can work.

In 2018, Harvard University experimental surgeon Harald Ott reported that he pumped billions of human cells (from umbilical cords and diced lungs) into a pig lung stripped of its own cells. When Ott’s team reconnected it to a pig’s circulation, the resulting organ showed rudimentary function.

Humanizing Pig Lungs
Another of Rothblatt’s organ manufacturing strategies is called xenotransplantation, the idea of transplanting an animal’s organs into humans who need a replacement.

Given the fact that adult pig organs are similar in size and shape to those of humans, United Therapeutics has focused on genetically engineering pigs to allow humans to use their organs. “It’s actually not rocket science,” said Rothblatt in her 2015 TED talk. “It’s editing one gene after another.”

To accomplish this goal, United Therapeutics made a series of investments in companies such as Revivicor Inc. and Synthetic Genomics Inc., and signed large funding agreements with the University of Maryland, University of Alabama, and New York Presbyterian/Columbia University Medical Center to create xenotransplantation programs for new hearts, kidneys, and lungs, respectively. Rothblatt hopes to see human translation in three to four years.

In preparation for that day, United Therapeutics owns a 132-acre property in Research Triangle Park and built a 275,000-square-foot medical laboratory that will ultimately have the capability to annually produce up to 1,000 sets of healthy pig lungs—known as xenolungs—from genetically engineered pigs.

Lung Ex Vivo Perfusion Systems
Beyond 3D printing and genetically engineering pig lungs, Rothblatt has already begun implementing a third near-term approach to improve the supply of lungs across the US.

Only about 30 percent of potential donor lungs meet transplant criteria in the first place; of those, only about 85 percent of those are usable once they arrive at the surgery center. As a result, nearly 75 percent of possible lungs never make it to the recipient in need.

What if these lungs could be rejuvenated? This concept informs Dr. Rothblatt’s next approach.

In 2016, United Therapeutics invested $41.8 million in TransMedics Inc., an Andover, Massachusetts company that develops ex vivo perfusion systems for donor lungs, hearts, and kidneys.

The XVIVO Perfusion System takes marginal-quality lungs that initially failed to meet transplantation standard-of-care criteria and perfuses and ventilates them at normothermic conditions, providing an opportunity for surgeons to reassess transplant suitability.

Rejuvenate Young Blood and Parabiosis
In HBO’s parody of the Bay Area tech community, Silicon Valley, one of the episodes (Season 4, Episode 5) is named “The Blood Boy.”

In this installment, tech billionaire Gavin Belson (Matt Ross) is meeting with Richard Hendricks (Thomas Middleditch) and his team, speaking about the future of the decentralized internet. A young, muscled twenty-something disrupts the meeting when he rolls in a transfusion stand and silently hooks an intravenous connection between himself and Belson.

Belson then introduces the newcomer as his “transfusion associate” and begins to explain the science of parabiosis: “Regular transfusions of the blood of a younger physically fit donor can significantly retard the aging process.”

While the sitcom is fiction, that science has merit, and the scenario portrayed in the episode is already happening today.

On the first point, research at Stanford and Harvard has demonstrated that older animals, when transfused with the blood of young animals, experience regeneration across many tissues and organs.

The opposite is also true: young animals, when transfused with the blood of older animals, experience accelerated aging. But capitalizing on this virtual fountain of youth has been tricky.

Ambrosia
One company, a San Francisco-based startup called Ambrosia, recently commenced one of the trials on parabiosis. Their protocol is simple: Healthy participants aged 35 and older get a transfusion of blood plasma from donors under 25, and researchers monitor their blood over the next two years for molecular indicators of health and aging.

Ambrosia’s founder Jesse Karmazin became interested in launching a company around parabiosis after seeing impressive data from animals and studies conducted abroad in humans: In one trial after another, subjects experience a reversal of aging symptoms across every major organ system. “The effects seem to be almost permanent,” he said. “It’s almost like there’s a resetting of gene expression.”

Infusing your own cord blood stem cells as you age may have tremendous longevity benefits. Following an FDA press release in February 2019, Ambrosia halted its consumer-facing treatment after several months of operation.

Understandably, the FDA raised concerns about the practice of parabiosis because to date, there is a marked lack of clinical data to support the treatment’s effectiveness.

Elevian
On the other end of the reputability spectrum is a startup called Elevian, spun out of Harvard University. Elevian is approaching longevity with a careful, scientifically validated strategy. (Full Disclosure: I am both an advisor to and investor in Elevian.)

CEO Mark Allen, MD, is joined by a dozen MDs and Ph.Ds out of Harvard. Elevian’s scientific founders started the company after identifying specific circulating factors that may be responsible for the “young blood” effect.

One example: A naturally occurring molecule known as “growth differentiation factor 11,” or GDF11, when injected into aged mice, reproduces many of the regenerative effects of young blood, regenerating heart, brain, muscles, lungs, and kidneys.

More specifically, GDF11 supplementation reduces age-related cardiac hypertrophy, accelerates skeletal muscle repair, improves exercise capacity, improves brain function and cerebral blood flow, and improves metabolism.

Elevian is developing a number of therapeutics that regulate GDF11 and other circulating factors. The goal is to restore our body’s natural regenerative capacity, which Elevian believes can address some of the root causes of age-associated disease with the promise of reversing or preventing many aging-related diseases and extending the healthy lifespan.

Conclusion
In 1992, futurist Leland Kaiser coined the term “regenerative medicine”:

“A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.”

Since then, the powerful regenerative medicine industry has grown exponentially, and this rapid growth is anticipated to continue.

A dramatic extension of the human healthspan is just over the horizon. Soon, we’ll all have the regenerative superpowers previously relegated to a handful of animals and comic books.

What new opportunities open up when anybody, anywhere, and at anytime can regenerate, replenish, and replace entire organs and metabolic systems on command?

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