Tag Archives: science
#435793 Tiny Robots Carry Stem Cells Through a ...
Engineers have built microrobots to perform all sorts of tasks in the body, and can now add to that list another key skill: delivering stem cells. In a paper published today in Science Robotics, researchers describe propelling a magnetically-controlled, stem-cell-carrying bot through a live mouse.
Under a rotating magnetic field, the microrobots moved with rolling and corkscrew-style locomotion. The researchers, led by Hongsoo Choi and his team at the Daegu Gyeongbuk Institute of Science & Technology (DGIST), in South Korea, also demonstrated their bot’s moves in slices of mouse brain, in blood vessels isolated from rat brains, and in a multi-organ-on-a chip.
The invention provides an alternative way to deliver stem cells, which are increasingly important in medicine. Such cells can be coaxed into becoming nearly any kind of cell, making them great candidates for treating neurodegenerative disorders such as Alzheimer’s.
But delivering stem cells typically requires an injection with a needle, which lowers the survival rate of the stem cells, and limits their reach in the body. Microrobots, however, have the potential to deliver stem cells to precise, hard-to-reach areas, with less damage to surrounding tissue, and better survival rates, says Jin-young Kim, a principle investigator at DGIST-ETH Microrobotics Research Center, and an author on the paper.
The virtues of microrobots have inspired several research groups to propose and test different designs in simple conditions, such as microfluidic channels and other static environments. A group out of Hong Kong last year described a burr-shaped bot that carried cells through live, transparent zebrafish.
The new research presents a magnetically-actuated microrobot that successfully carried stem cells through a live mouse. In additional experiments, the cells, which had differentiated into brain cells such as astrocytes, oligodendrocytes, and neurons, transferred to microtissues on the multi-organ-on-a-chip. Taken together, the proof-of-concept experiments demonstrate the potential for microrobots to be used in human stem cell therapy, says Kim.
The team fabricated the robots with 3D laser lithography, and designed them in two shapes: spherical and helical. Using a rotating magnetic field, the scientists navigated the spherical-shaped bots with a rolling motion, and the helical bots with a corkscrew motion. These styles of locomotion proved more efficient than that from a simple pulling force, and were more suitable for use in biological fluids, the scientists reported.
The big challenge in navigating microbots in a live animal (or human body) is being able to see them in real time. Imaging with fMRI doesn’t work, because the magnetic fields interfere with the system. “To precisely control microbots in vivo, it is important to actually see them as they move,” the authors wrote in their paper.
That wasn’t possible during experiments in a live mouse, so the researchers had to check the location of the microrobots before and after the experiments using an optical tomography system called IVIS. They also had to resort to using a pulling force with a permanent magnet to navigate the microrobots inside the mouse, due to the limitations of the IVIS system.
Kim says he and his colleagues are developing imaging systems that will enable them to view in real time the locomotion of their microrobots in live animals. Continue reading
Posted in Human Robots
#435775 Jaco Is a Low-Power Robot Arm That Hooks ...
We usually think of robots as taking the place of humans in various tasks, but robots of all kinds can also enhance human capabilities. This may be especially true for people with disabilities. And while the Cybathlon competition showed what's possible when cutting-edge research robotics is paired with expert humans, that competition isn't necessarily reflective of the kind of robotics available to most people today.
Kinova Robotics's Jaco arm is an assistive robotic arm designed to be mounted on an electric wheelchair. With six degrees of freedom plus a three-fingered gripper, the lightweight carbon fiber arm is frequently used in research because it's rugged and versatile. But from the start, Kinova created it to add autonomy to the lives of people with mobility constraints.
Earlier this year, Kinova shared the story of Mary Nelson, an 11-year-old girl with spinal muscular atrophy, who uses her Jaco arm to show her horse in competition. Spinal muscular atrophy is a neuromuscular disorder that impairs voluntary muscle movement, including muscles that help with respiration, and Mary depends on a power chair for mobility.
We wanted to learn more about how Kinova designs its Jaco arm, and what that means for folks like Mary, so we spoke with both Kinova and Mary's parents to find out how much of a difference a robot arm can make.
IEEE Spectrum: How did Mary interact with the world before having her arm, and what was involved in the decision to try a robot arm in general? And why then Kinova's arm specifically?
Ryan Nelson: Mary interacts with the world much like you and I do, she just uses different tools to do so. For example, she is 100 percent independent using her computer, iPad, and phone, and she prefers to use a mouse. However, she cannot move a standard mouse, so she connects her wheelchair to each device with Bluetooth to move the mouse pointer/cursor using her wheelchair joystick.
For years, we had a Manfrotto magic arm and super clamp attached to her wheelchair and she used that much like the robotic arm. We could put a baseball bat, paint brush, toys, etc. in the super clamp so that Mary could hold the object and interact as physically able children do. Mary has always wanted to be more independent, so we knew the robotic arm was something she must try. We had seen videos of the Kinova arm on YouTube and on their website, so we reached out to them to get a trial.
Can you tell us about the Jaco arm, and how the process of designing an assistive robot arm is different from the process of designing a conventional robot arm?
Nathaniel Swenson, Director of U.S. Operations — Assistive Technologies at Kinova: Jaco is our flagship robotic arm. Inspired by our CEO's uncle and its namesake, Jacques “Jaco” Forest, it was designed as assistive technology with power wheelchair users in mind.
The primary differences between Jaco and our other robots, such as the new Gen3, which was designed to meet the needs of academic and industry research teams, are speed and power consumption. Other robots such as the Gen3 can move faster and draw slightly more power because they aren't limited by the battery size of power wheelchairs. Depending on the use case, they might not interact directly with a human being in the research setting and can safely move more quickly. Jaco is designed to move at safe speeds and make direct contact with the end user and draw very little power directly from their wheelchair.
The most important consideration in the design process of an assistive robot is the safety of the end user. Jaco users operate their robots through their existing drive controls to assist them in daily activities such as eating, drinking, and opening doors and they don't have to worry about the robot draining their chair's batteries throughout the day. The elegant design that results from meeting the needs of our power chair users has benefited subsequent iterations, [of products] such as the Gen3, as well: Kinova's robots are lightweight, extremely efficient in their power consumption, and safe for direct human-robot interaction. This is not true of conventional industrial robots.
What was the learning process like for Mary? Does she feel like she's mastered the arm, or is it a continuous learning process?
Ryan Nelson: The learning process was super quick for Mary. However, she amazes us every day with the new things that she can do with the arm. Literally within minutes of installing the arm on her chair, Mary had it figured out and was shaking hands with the Kinova rep. The control of the arm is super intuitive and the Kinova reps say that SMA (Spinal Muscular Atrophy) children are perfect users because they are so smart—they pick it up right away. Mary has learned to do many fine motor tasks with the arm, from picking up small objects like a pencil or a ruler, to adjusting her glasses on her face, to doing science experiments.
Photo: The Nelson Family
Mary uses a headset microphone to amplify her voice, and she will use the arm and finger to adjust the microphone in front of her mouth after she is done eating (also a task she mastered quickly with the arm). Additionally, Mary will use the arms to reach down and adjust her feet or leg by grabbing them with the arm and moving them to a more comfortable position. All of these examples are things she never really asked us to do, but something she needed and just did on her own, with the help of the arm.
What is the most common feedback that you get from new users of the arm? How about from experienced users who have been using the arm for a while?
Nathaniel Swenson: New users always tell us how excited they are to see what they can accomplish with their new Jaco. From day one, they are able to do things that they have longed to do without assistance from a caregiver: take a drink of water or coffee, scratch an itch, push the button to open an “accessible” door or elevator, or even feed their baby with a bottle.
The most common feedback I hear from experienced users is that Jaco has changed their life. Our experienced users like Mary are rock stars: everywhere they go, people get excited to see what they'll do next. The difference between a new user and an experienced user could be as little as two weeks. People who operate power wheelchairs every day are already expert drivers and we just add a new “gear” to their chair: robot mode. It's fun to see how quickly new users master the intuitive Jaco control modes.
What changes would you like to see in the next generation of Jaco arm?
Ryan Nelson: Titanium fingers! Make it lift heavier objects, hold heavier items like a baseball bat, machine gun, flame thrower, etc., and Mary literally said this last night: “I wish the arm moved fast enough to play the piano.”
Nathaniel Swenson: I love the idea of titanium fingers! Jaco's fingers are made from a flexible polymer and designed to avoid harm. This allows the fingers to bend or dislocate, rather than break, but it also means they are not as durable as a material like titanium. Increased payload, the ability to manipulate heavier objects, requires increased power consumption. We've struck a careful balance between providing enough strength to accomplish most medically necessary Activities of Daily Living and efficient use of the power chair's batteries.
We take Isaac Asimov's Laws of Robotics pretty seriously. When we start to combine machine guns, flame throwers, and artificial intelligence with robots, I get very nervous!
I wish the arm moved fast enough to play the piano, too! I am also a musician and I share Mary's dream of an assistive robot that would enable her to make music. In the meantime, while we work on that, please enjoy this beautiful violin piece by Manami Ito and her one-of-a-kind violin prosthesis:
To what extent could more autonomy for the arm be helpful for users? What would be involved in implementing that?
Nathaniel Swenson: Artificial intelligence, machine learning, and deep learning will introduce greater autonomy in future iterations of assistive robots. This will enable them to perform more complex tasks that aren't currently possible, and enable them to accomplish routine tasks more quickly and with less input than the current manual control requires.
For assistive robots, implementation of greater autonomy involves a focus on end-user safety and improvements in the robot's awareness of its environment. Autonomous robots that work in close proximity with humans need vision. They must be able to see to avoid collisions and they use haptic feedback to tell the robot how much force is being exerted on objects. All of these technologies exist, but the largest obstacle to bringing them to the assistive technology market is to prove to the health insurance companies who will fund them that they are both safe and medically necessary. Continue reading
Posted in Human Robots
#435769 The Ultimate Optimization Problem: How ...
Lucas Joppa thinks big. Even while gazing down into his cup of tea in his modest office on Microsoft’s campus in Redmond, Washington, he seems to see the entire planet bobbing in there like a spherical tea bag.
As Microsoft’s first chief environmental officer, Joppa came up with the company’s AI for Earth program, a five-year effort that’s spending US $50 million on AI-powered solutions to global environmental challenges.
The program is not just about specific deliverables, though. It’s also about mindset, Joppa told IEEE Spectrum in an interview in July. “It’s a plea for people to think about the Earth in the same way they think about the technologies they’re developing,” he says. “You start with an objective. So what’s our objective function for Earth?” (In computer science, an objective function describes the parameter or parameters you are trying to maximize or minimize for optimal results.)
Photo: Microsoft
Lucas Joppa
AI for Earth launched in December 2017, and Joppa’s team has since given grants to more than 400 organizations around the world. In addition to receiving funding, some grantees get help from Microsoft’s data scientists and access to the company’s computing resources.
In a wide-ranging interview about the program, Joppa described his vision of the “ultimate optimization problem”—figuring out which parts of the planet should be used for farming, cities, wilderness reserves, energy production, and so on.
Every square meter of land and water on Earth has an infinite number of possible utility functions. It’s the job of Homo sapiens to describe our overall objective for the Earth. Then it’s the job of computers to produce optimization results that are aligned with the human-defined objective.
I don’t think we’re close at all to being able to do this. I think we’re closer from a technology perspective—being able to run the model—than we are from a social perspective—being able to make decisions about what the objective should be. What do we want to do with the Earth’s surface?
Such questions are increasingly urgent, as climate change has already begun reshaping our planet and our societies. Global sea and air surface temperatures have already risen by an average of 1 degree Celsius above preindustrial levels, according to the Intergovernmental Panel on Climate Change.
Today, people all around the world participated in a “climate strike,” with young people leading the charge and demanding a global transition to renewable energy. On Monday, world leaders will gather in New York for the United Nations Climate Action Summit, where they’re expected to present plans to limit warming to 1.5 degrees Celsius.
Joppa says such summit discussions should aim for a truly holistic solution.
We talk about how to solve climate change. There’s a higher-order question for society: What climate do we want? What output from nature do we want and desire? If we could agree on those things, we could put systems in place for optimizing our environment accordingly. Instead we have this scattered approach, where we try for local optimization. But the sum of local optimizations is never a global optimization.
There’s increasing interest in using artificial intelligence to tackle global environmental problems. New sensing technologies enable scientists to collect unprecedented amounts of data about the planet and its denizens, and AI tools are becoming vital for interpreting all that data.
The 2018 report “Harnessing AI for the Earth,” produced by the World Economic Forum and the consulting company PwC, discusses ways that AI can be used to address six of the world’s most pressing environmental challenges (climate change, biodiversity, and healthy oceans, water security, clean air, and disaster resilience).
Many of the proposed applications involve better monitoring of human and natural systems, as well as modeling applications that would enable better predictions and more efficient use of natural resources.
Joppa says that AI for Earth is taking a two-pronged approach, funding efforts to collect and interpret vast amounts of data alongside efforts that use that data to help humans make better decisions. And that’s where the global optimization engine would really come in handy.
For any location on earth, you should be able to go and ask: What’s there, how much is there, and how is it changing? And more importantly: What should be there?
On land, the data is really only interesting for the first few hundred feet. Whereas in the ocean, the depth dimension is really important.
We need a planet with sensors, with roving agents, with remote sensing. Otherwise our decisions aren’t going to be any good.
AI for Earth isn’t going to create such an online portal within five years, Joppa stresses. But he hopes the projects that he’s funding will contribute to making such a portal possible—eventually.
We’re asking ourselves: What are the fundamental missing layers in the tech stack that would allow people to build a global optimization engine? Some of them are clear, some are still opaque to me.
By the end of five years, I’d like to have identified these missing layers, and have at least one example of each of the components.
Some of the projects that AI for Earth has funded seem to fit that desire. Examples include SilviaTerra, which used satellite imagery and AI to create a map of the 92 billion trees in forested areas across the United States. There’s also OceanMind, a non-profit that detects illegal fishing and helps marine authorities enforce compliance. Platforms like Wildbook and iNaturalist enable citizen scientists to upload pictures of animals and plants, aiding conservation efforts and research on biodiversity. And FarmBeats aims to enable data-driven agriculture with low-cost sensors, drones, and cloud services.
It’s not impossible to imagine putting such services together into an optimization engine that knows everything about the land, the water, and the creatures who live on planet Earth. Then we’ll just have to tell that engine what we want to do about it.
Editor’s note: This story is published in cooperation with more than 250 media organizations and independent journalists that have focused their coverage on climate change ahead of the UN Climate Action Summit. IEEE Spectrum’s participation in the Covering Climate Now partnership builds on our past reporting about this global issue. Continue reading
Posted in Human Robots