Tag Archives: Science Robotics

#435793 Tiny Robots Carry Stem Cells Through a ...

Posted on September 21, 2019 by Android

Engineers have built microrobots to perform all sorts of tasks in the body, and can now add to that list another key skill: delivering stem cells. In a paper published today in Science Robotics, researchers describe propelling a magnetically-controlled, stem-cell-carrying bot through a live mouse.

Under a rotating magnetic field, the microrobots moved with rolling and corkscrew-style locomotion. The researchers, led by Hongsoo Choi and his team at the Daegu Gyeongbuk Institute of Science & Technology (DGIST), in South Korea, also demonstrated their bot’s moves in slices of mouse brain, in blood vessels isolated from rat brains, and in a multi-organ-on-a chip.

The invention provides an alternative way to deliver stem cells, which are increasingly important in medicine. Such cells can be coaxed into becoming nearly any kind of cell, making them great candidates for treating neurodegenerative disorders such as Alzheimer’s.

But delivering stem cells typically requires an injection with a needle, which lowers the survival rate of the stem cells, and limits their reach in the body. Microrobots, however, have the potential to deliver stem cells to precise, hard-to-reach areas, with less damage to surrounding tissue, and better survival rates, says Jin-young Kim, a principle investigator at DGIST-ETH Microrobotics Research Center, and an author on the paper.

The virtues of microrobots have inspired several research groups to propose and test different designs in simple conditions, such as microfluidic channels and other static environments. A group out of Hong Kong last year described a burr-shaped bot that carried cells through live, transparent zebrafish.

The new research presents a magnetically-actuated microrobot that successfully carried stem cells through a live mouse. In additional experiments, the cells, which had differentiated into brain cells such as astrocytes, oligodendrocytes, and neurons, transferred to microtissues on the multi-organ-on-a-chip. Taken together, the proof-of-concept experiments demonstrate the potential for microrobots to be used in human stem cell therapy, says Kim.

The team fabricated the robots with 3D laser lithography, and designed them in two shapes: spherical and helical. Using a rotating magnetic field, the scientists navigated the spherical-shaped bots with a rolling motion, and the helical bots with a corkscrew motion. These styles of locomotion proved more efficient than that from a simple pulling force, and were more suitable for use in biological fluids, the scientists reported.

The big challenge in navigating microbots in a live animal (or human body) is being able to see them in real time. Imaging with fMRI doesn’t work, because the magnetic fields interfere with the system. “To precisely control microbots in vivo, it is important to actually see them as they move,” the authors wrote in their paper.

That wasn’t possible during experiments in a live mouse, so the researchers had to check the location of the microrobots before and after the experiments using an optical tomography system called IVIS. They also had to resort to using a pulling force with a permanent magnet to navigate the microrobots inside the mouse, due to the limitations of the IVIS system.

Kim says he and his colleagues are developing imaging systems that will enable them to view in real time the locomotion of their microrobots in live animals. Continue reading →

Posted in Human Robots

#435722 Stochastic Robots Use Randomness to ...

Posted on September 18, 2019 by Android

The idea behind swarm robots is to replace discrete, expensive, breakable uni-tasking components with a whole bunch of much simpler, cheaper, and replaceable robots that can work together to do the same sorts of tasks. Unfortunately, all of those swarm robots end up needing their own computing and communications and stuff if you want to get them to do what you want them to do.

A different approach to swarm robotics is to use a swarm of much cheaper robots that are far less intelligent. In fact, they may not have to be intelligent at all, if you can rely on their physical characteristics to drive them instead. These swarms are “stochastic,” meaning that their motions are randomly determined, but if you’re clever and careful, you can still get them to do specific things.

Georgia Tech has developed some little swarm robots called “smarticles” that can’t really do much at all on their own, but once you put them together into a jumble, their randomness can actually accomplish something.

Honestly, calling these particle robots “smart” might be giving them a bit too much credit, because they’re actually kind of dumb and strictly speaking not capable of all that much on their own. A single smarticle weighs 35 grams, and consists of some little 3D-printed flappy bits attached to servos, plus an Arduino Pro Mini, a battery, and a light or sound sensor. When its little flappy bits are activated, each smarticle can move slightly, but a single one mostly just moves around in a square and then will gradually drift in a mostly random direction over time.

It gets more interesting when you throw a whole bunch of smarticles into a constrained area. A small collection of five or 10 smarticles constrained together form a “supersmarticle,” but besides being in close proximity to one another, the smarticles within the supersmarticle aren’t communicating or anything like that. As far as each smarticle is concerned, they’re independent, but weirdly, a bumble of them can work together without working together.

“These are very rudimentary robots whose behavior is dominated by mechanics and the laws of physics,” said Dan Goldman, a Dunn Family Professor in the School of Physics at the Georgia Institute of Technology.

The researchers noticed that if one small robot stopped moving, perhaps because its battery died, the group of smarticles would begin moving in the direction of that stalled robot. Graduate student Ross Warkentin learned he could control the movement by adding photo sensors to the robots that halt the arm flapping when a strong beam of light hits one of them.

“If you angle the flashlight just right, you can highlight the robot you want to be inactive, and that causes the ring to lurch toward or away from it, even though no robots are programmed to move toward the light,” Goldman said. “That allowed steering of the ensemble in a very rudimentary, stochastic way.”

It turns out that it’s possible to model this behavior, and control a supersmarticle with enough fidelity to steer it through a maze. And while these particular smarticles aren’t all that small, strictly speaking, the idea is to develop techniques that will work when robots are scaled way way down to the point where you can't physically fit useful computing in there at all.

The researchers are also working on some other concepts, like these:

Image: Science Robotics

The Georgia Tech researchers envision stochastic robot swarms that don’t have a perfectly defined shape or delineation but are capable of self-propulsion, relying on the ensemble-level behaviors that lead to collective locomotion. In such a robot, the researchers say, groups of largely generic agents may be able to achieve complex goals, as observed in biological collectives.

Er, yeah. I’m…not sure I really want there to be a bipedal humanoid robot built out of a bunch of tiny robots. Like, that seems creepy somehow, you know? I’m totally okay with slugs, but let’s not get crazy.

“A robot made of robots: Emergent transport and control of a smarticle ensemble, by William Savoie, Thomas A. Berrueta, Zachary Jackson, Ana Pervan, Ross Warkentin, Shengkai Li, Todd D. Murphey, Kurt Wiesenfeld, and Daniel I. Goldman” from the Georgia Institute of Technology, appears in the current issue of Science Robotics. Continue reading →

Posted in Human Robots

#435648 Surprisingly Speedy Soft Robot Survives ...

Posted on September 14, 2019 by Android

Soft robots are getting more and more popular for some very good reasons. Their relative simplicity is one. Their relative low cost is another. And for their simplicity and low cost, they’re generally able to perform very impressively, leveraging the unique features inherent to their design and construction to move themselves and interact with their environment. The other significant reason why soft robots are so appealing is that they’re durable. Without the constraints of rigid parts, they can withstand the sort of abuse that would make any roboticist cringe.

In the current issue of Science Robotics, a group of researchers from Tsinghua University in China and University of California, Berkeley, present a new kind of soft robot that’s both higher performance and much more robust than just about anything we’ve seen before. The deceptively simple robot looks like a bent strip of paper, but it’s able to move at 20 body lengths per second and survive being stomped on by a human wearing tennis shoes. Take that, cockroaches.

This prototype robot measures just 3 centimeters by 1.5 cm. It takes a scanning electron microscope to actually see what the robot is made of—a thermoplastic layer is sandwiched by palladium-gold electrodes, bonded with adhesive silicone to a structural plastic at the bottom. When an AC voltage (as low as 8 volts but typically about 60 volts) is run through the electrodes, the thermoplastic extends and contracts, causing the robot’s back to flex and the little “foot” to shuffle. A complete step cycle takes just 50 milliseconds, yielding a 200 hertz gait. And technically, the robot “runs,” since it does have a brief aerial phase.

Image: Science Robotics

Photos from a high-speed camera show the robot’s gait (A to D) as it contracts and expands its body.

To put the robot’s top speed of 20 body lengths per second in perspective, have a look at this nifty chart, which shows where other animals relative running speeds of some animals and robots versus body mass:

Image: Science Robotics

This chart shows the relative running speeds of some mammals (purple area), arthropods (orange area), and soft robots (blue area) versus body mass. For both mammals and arthropods, relative speeds show a strong negative scaling law with respect to the body mass: speeds increase as body masses decrease. However, for soft robots, the relationship appears to be the opposite: speeds decrease as the body mass decrease. For the little soft robots created by the researchers from Tsinghua University and UC Berkeley (red stars), the scaling law is similar to that of living animals: Higher speed was attained as the body mass decreased.

If you were wondering, like we were, just what that number 39 is on that chart (top left corner), it’s a species of tiny mite that was discovered underneath a rock in California in 1916. The mite is just under 1 mm in size, but it can run at 0.8 kilometer per hour, which is 322 body lengths per second, making it by far (like, by a factor of two at least) the fastest land animal on Earth relative to size. If a human was to run that fast relative to our size, we’d be traveling at a little bit over 2,000 kilometers per hour. It’s not a coincidence that pretty much everything in the upper left of the chart is an insect—speed scales favorably with decreasing mass, since actuators have a proportionally larger effect.

Other notable robots on the chart with impressive speed to mass ratios are number 27, which is this magnetically driven quadruped robot from UMD, and number 86, UC Berkeley’s X2-VelociRoACH.

Anyway, back to this robot. Some other cool things about it:

You can step on it, squishing it flat with a load about 1 million times its own body weight, and it’ll keep on crawling, albeit only half as fast.
Even climbing a slope of 15 degrees, it can still manage to move at 1 body length per second.
It carries peanuts! With a payload of six times its own weight, it moves a sixth as fast, but still, it’s not like you need your peanuts delivered all that quickly anyway, do you?

Image: Science Robotics

The researchers also put together a prototype with two legs instead of one, which was able to demonstrate a potentially faster galloping gait by spending more time in the air. They suggest that robots like these could be used for “environmental exploration, structural inspection, information reconnaissance, and disaster relief,” which are the sorts of things that you suggest that your robot could be used for when you really have no idea what it could be used for. But this work is certainly impressive, with speed and robustness that are largely unmatched by other soft robots. An untethered version seems possible due to the relatively low voltages required to drive the robot, and if they can put some peanut-sized sensors on there as well, practical applications might actually be forthcoming sometime soon.

“Insect-scale Fast Moving and Ultrarobust Soft Robot,” by Yichuan Wu, Justin K. Yim, Jiaming Liang, Zhichun Shao, Mingjing Qi, Junwen Zhong, Zihao Luo, Xiaojun Yan, Min Zhang, Xiaohao Wang, Ronald S. Fearing, Robert J. Full, and Liwei Lin from Tsinghua University and UC Berkeley, is published in Science Robotics. Continue reading →

Posted in Human Robots

#435597 Water Jet Powered Drone Takes Off With ...

Posted on September 12, 2019 by Android

At ICRA 2015, the Aerial Robotics Lab at the Imperial College London presented a concept for a multimodal flying swimming robot called AquaMAV. The really difficult thing about a flying and swimming robot isn’t so much the transition from the first to the second, since you can manage that even if your robot is completely dead (thanks to gravity), but rather the other way: going from water to air, ideally in a stable and repetitive way. The AquaMAV concept solved this by basically just applying as much concentrated power as possible to the problem, using a jet thruster to hurl the robot out of the water with quite a bit of velocity to spare.

In a paper appearing in Science Robotics this week, the roboticists behind AquaMAV present a fully operational robot that uses a solid-fuel powered chemical reaction to generate an explosion that powers the robot into the air.

The 2015 version of AquaMAV, which was mostly just some very vintage-looking computer renderings and a little bit of hardware, used a small cylinder of CO2 to power its water jet thruster. This worked pretty well, but the mass and complexity of the storage and release mechanism for the compressed gas wasn’t all that practical for a flying robot designed for long-term autonomy. It’s a familiar challenge, especially for pneumatically powered soft robots—how do you efficiently generate gas on-demand, especially if you need a lot of pressure all at once?

An explosion propels the drone out of the water
There’s one obvious way of generating large amounts of pressurized gas all at once, and that’s explosions. We’ve seen robots use explosive thrust for mobility before, at a variety of scales, and it’s very effective as long as you can both properly harness the explosion and generate the fuel with a minimum of fuss, and this latest version of AquaMAV manages to do both:

The water jet coming out the back of this robot aircraft is being propelled by a gas explosion. The gas comes from the reaction between a little bit of calcium carbide powder stored inside the robot, and water. Water is mixed with the powder one drop at a time, producing acetylene gas, which gets piped into a combustion chamber along with air and water. When ignited, the acetylene air mixture explodes, forcing the water out of the combustion chamber and providing up to 51 N of thrust, which is enough to launch the 160-gram robot 26 meters up and over the water at 11 m/s. It takes just 50 mg of calcium carbide (mixed with 3 drops of water) to generate enough acetylene for each explosion, and both air and water are of course readily available. With 0.2 g of calcium carbide powder on board, the robot has enough fuel for multiple jumps, and the jump is powerful enough that the robot can get airborne even under fairly aggressive sea conditions.

Image: Science Robotics

The robot can transition from a floating state to an airborne jetting phase and back to floating (A). A 3D model render of the underside of the robot (B) shows the electronics capsule. The capsule contains the fuel tank (C), where calcium carbide reacts with air and water to propel the vehicle.

Next step: getting the robot to fly autonomously
Providing adequate thrust is just one problem that needs to be solved when attempting to conquer the water-air transition with a fixed-wing robot. The overall design of the robot itself is a challenge as well, because the optimal design and balance for the robot is quite different in each phase of operation, as the paper describes:

For the vehicle to fly in a stable manner during the jetting phase, the center of mass must be a significant distance in front of the center of pressure of the vehicle. However, to maintain a stable floating position on the water surface and the desired angle during jetting, the center of mass must be located behind the center of buoyancy. For the gliding phase, a fine balance between the center of mass and the center of pressure must be struck to achieve static longitudinal flight stability passively. During gliding, the center of mass should be slightly forward from the wing’s center of pressure.

The current version is mostly optimized for the jetting phase of flight, and doesn’t have any active flight control surfaces yet, but the researchers are optimistic that if they added some they’d have no problem getting the robot to fly autonomously. It’s just a glider at the moment, but a low-power propeller is the obvious step after that, and to get really fancy, a switchable gearbox could enable efficient movement on water as well as in the air. Long-term, the idea is that robots like these would be useful for tasks like autonomous water sampling over large areas, but I’d personally be satisfied with a remote controlled version that I could take to the beach.

“Consecutive aquatic jump-gliding with water-reactive fuel,” by R. Zufferey, A. Ortega Ancel, A. Farinha, R. Siddall, S. F. Armanini, M. Nasr, R. V. Brahmal, G. Kennedy, and M. Kovac from Imperial College in London, is published in the current issue of Science Robotics. Continue reading →

Posted in Human Robots

#435423 Moving Beyond Mind-Controlled Limbs to ...

Posted on July 31, 2019 by Android

Brain-machine interface enthusiasts often gush about “closing the loop.” It’s for good reason. On the implant level, it means engineering smarter probes that only activate when they detect faulty electrical signals in brain circuits. Elon Musk’s Neuralink—among other players—are readily pursuing these bi-directional implants that both measure and zap the brain.

But to scientists laboring to restore functionality to paralyzed patients or amputees, “closing the loop” has broader connotations. Building smart mind-controlled robotic limbs isn’t enough; the next frontier is restoring sensation in offline body parts. To truly meld biology with machine, the robotic appendage has to “feel one” with the body.

This month, two studies from Science Robotics describe complementary ways forward. In one, scientists from the University of Utah paired a state-of-the-art robotic arm—the DEKA LUKE—with electrically stimulating remaining nerves above the attachment point. Using artificial zaps to mimic the skin’s natural response patterns to touch, the team dramatically increased the patient’s ability to identify objects. Without much training, he could easily discriminate between the small and large and the soft and hard while blindfolded and wearing headphones.

In another, a team based at the National University of Singapore took inspiration from our largest organ, the skin. Mimicking the neural architecture of biological skin, the engineered “electronic skin” not only senses temperature, pressure, and humidity, but continues to function even when scraped or otherwise damaged. Thanks to artificial nerves that transmit signals far faster than our biological ones, the flexible e-skin shoots electrical data 1,000 times quicker than human nerves.

Together, the studies marry neuroscience and robotics. Representing the latest push towards closing the loop, they show that integrating biological sensibilities with robotic efficiency isn’t impossible (super-human touch, anyone?). But more immediately—and more importantly—they’re beacons of hope for patients who hope to regain their sense of touch.

For one of the participants, a late middle-aged man with speckled white hair who lost his forearm 13 years ago, superpowers, cyborgs, or razzle-dazzle brain implants are the last thing on his mind. After a barrage of emotionally-neutral scientific tests, he grasped his wife’s hand and felt her warmth for the first time in over a decade. His face lit up in a blinding smile.

That’s what scientists are working towards.

Biomimetic Feedback
The human skin is a marvelous thing. Not only does it rapidly detect a multitude of sensations—pressure, temperature, itch, pain, humidity—its wiring “binds” disparate signals together into a sensory fingerprint that helps the brain identify what it’s feeling at any moment. Thanks to over 45 miles of nerves that connect the skin, muscles, and brain, you can pick up a half-full coffee cup, knowing that it’s hot and sloshing, while staring at your computer screen. Unfortunately, this complexity is also why restoring sensation is so hard.

The sensory electrode array implanted in the participant’s arm. Image Credit: George et al., Sci. Robot. 4, eaax2352 (2019)..
However, complex neural patterns can also be a source of inspiration. Previous cyborg arms are often paired with so-called “standard” sensory algorithms to induce a basic sense of touch in the missing limb. Here, electrodes zap residual nerves with intensities proportional to the contact force: the harder the grip, the stronger the electrical feedback. Although seemingly logical, that’s not how our skin works. Every time the skin touches or leaves an object, its nerves shoot strong bursts of activity to the brain; while in full contact, the signal is much lower. The resulting electrical strength curve resembles a “U.”

The LUKE hand. Image Credit: George et al., Sci. Robot. 4, eaax2352 (2019).
The team decided to directly compare standard algorithms with one that better mimics the skin’s natural response. They fitted a volunteer with a robotic LUKE arm and implanted an array of electrodes into his forearm—right above the amputation—to stimulate the remaining nerves. When the team activated different combinations of electrodes, the man reported sensations of vibration, pressure, tapping, or a sort of “tightening” in his missing hand. Some combinations of zaps also made him feel as if he were moving the robotic arm’s joints.

In all, the team was able to carefully map nearly 120 sensations to different locations on the phantom hand, which they then overlapped with contact sensors embedded in the LUKE arm. For example, when the patient touched something with his robotic index finger, the relevant electrodes sent signals that made him feel as if he were brushing something with his own missing index fingertip.

Standard sensory feedback already helped: even with simple electrical stimulation, the man could tell apart size (golf versus lacrosse ball) and texture (foam versus plastic) while blindfolded and wearing noise-canceling headphones. But when the team implemented two types of neuromimetic feedback—electrical zaps that resembled the skin’s natural response—his performance dramatically improved. He was able to identify objects much faster and more accurately under their guidance. Outside the lab, he also found it easier to cook, feed, and dress himself. He could even text on his phone and complete routine chores that were previously too difficult, such as stuffing an insert into a pillowcase, hammering a nail, or eating hard-to-grab foods like eggs and grapes.

The study shows that the brain more readily accepts biologically-inspired electrical patterns, making it a relatively easy—but enormously powerful—upgrade that seamlessly integrates the robotic arms with the host. “The functional and emotional benefits…are likely to be further enhanced with long-term use, and efforts are underway to develop a portable take-home system,” the team said.

E-Skin Revolution: Asynchronous Coded Electronic Skin (ACES)
Flexible electronic skins also aren’t new, but the second team presented an upgrade in both speed and durability while retaining multiplexed sensory capabilities.

Starting from a combination of rubber, plastic, and silicon, the team embedded over 200 sensors onto the e-skin, each capable of discerning contact, pressure, temperature, and humidity. They then looked to the skin’s nervous system for inspiration. Our skin is embedded with a dense array of nerve endings that individually transmit different types of sensations, which are integrated inside hubs called ganglia. Compared to having every single nerve ending directly ping data to the brain, this “gather, process, and transmit” architecture rapidly speeds things up.

The team tapped into this biological architecture. Rather than pairing each sensor with a dedicated receiver, ACES sends all sensory data to a single receiver—an artificial ganglion. This setup lets the e-skin’s wiring work as a whole system, as opposed to individual electrodes. Every sensor transmits its data using a characteristic pulse, which allows it to be uniquely identified by the receiver.

The gains were immediate. First was speed. Normally, sensory data from multiple individual electrodes need to be periodically combined into a map of pressure points. Here, data from thousands of distributed sensors can independently go to a single receiver for further processing, massively increasing efficiency—the new e-skin’s transmission rate is roughly 1,000 times faster than that of human skin.

Second was redundancy. Because data from individual sensors are aggregated, the system still functioned even when any individual receptors are damaged, making it far more resilient than previous attempts. Finally, the setup could easily scale up. Although the team only tested the idea with 240 sensors, theoretically the system should work with up to 10,000.

The team is now exploring ways to combine their invention with other material layers to make it water-resistant and self-repairable. As you might’ve guessed, an immediate application is to give robots something similar to complex touch. A sensory upgrade not only lets robots more easily manipulate tools, doorknobs, and other objects in hectic real-world environments, it could also make it easier for machines to work collaboratively with humans in the future (hey Wall-E, care to pass the salt?).

Dexterous robots aside, the team also envisions engineering better prosthetics. When coated onto cyborg limbs, for example, ACES may give them a better sense of touch that begins to rival the human skin—or perhaps even exceed it.

Regardless, efforts that adapt the functionality of the human nervous system to machines are finally paying off, and more are sure to come. Neuromimetic ideas may very well be the link that finally closes the loop.

Image Credit: Dan Hixson/University of Utah College of Engineering.. Continue reading →

Posted in Human Robots