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#435308 Brain-Machine Interfaces Are Getting ...

Elon Musk grabbed a lot of attention with his July 16 announcement that his company Neuralink plans to implant electrodes into the brains of people with paralysis by next year. Their first goal is to create assistive technology to help people who can’t move or are unable to communicate.

If you haven’t been paying attention, brain-machine interfaces (BMIs) that allow people to control robotic arms with their thoughts might sound like science fiction. But science and engineering efforts have already turned it into reality.

In a few research labs around the world, scientists and physicians have been implanting devices into the brains of people who have lost the ability to control their arms or hands for over a decade. In our own research group at the University of Pittsburgh, we’ve enabled people with paralyzed arms and hands to control robotic arms that allow them to grasp and move objects with relative ease. They can even experience touch-like sensations from their own hand when the robot grasps objects.

At its core, a BMI is pretty straightforward. In your brain, microscopic cells called neurons are sending signals back and forth to each other all the time. Everything you think, do and feel as you interact with the world around you is the result of the activity of these 80 billion or so neurons.

If you implant a tiny wire very close to one of these neurons, you can record the electrical activity it generates and send it to a computer. Record enough of these signals from the right area of the brain and it becomes possible to control computers, robots, or anything else you might want, simply by thinking about moving. But doing this comes with tremendous technical challenges, especially if you want to record from hundreds or thousands of neurons.

What Neuralink Is Bringing to the Table
Elon Musk founded Neuralink in 2017, aiming to address these challenges and raise the bar for implanted neural interfaces.

Perhaps the most impressive aspect of Neuralink’s system is the breadth and depth of their approach. Building a BMI is inherently interdisciplinary, requiring expertise in electrode design and microfabrication, implantable materials, surgical methods, electronics, packaging, neuroscience, algorithms, medicine, regulatory issues, and more. Neuralink has created a team that spans most, if not all, of these areas.

With all of this expertise, Neuralink is undoubtedly moving the field forward, and improving their technology rapidly. Individually, many of the components of their system represent significant progress along predictable paths. For example, their electrodes, that they call threads, are very small and flexible; many researchers have tried to harness those properties to minimize the chance the brain’s immune response would reject the electrodes after insertion. Neuralink has also developed high-performance miniature electronics, another focus area for labs working on BMIs.

Often overlooked in academic settings, however, is how an entire system would be efficiently implanted in a brain.

Neuralink’s BMI requires brain surgery. This is because implanted electrodes that are in intimate contact with neurons will always outperform non-invasive electrodes where neurons are far away from the electrodes sitting outside the skull. So, a critical question becomes how to minimize the surgical challenges around getting the device into a brain.

Maybe the most impressive aspect of Neuralink’s announcement was that they created a 3,000-electrode neural interface where electrodes could be implanted at a rate of between 30 and 200 per minute. Each thread of electrodes is implanted by a sophisticated surgical robot that essentially acts like a sewing machine. This all happens while specifically avoiding blood vessels that blanket the surface of the brain. The robotics and imaging that enable this feat, with tight integration to the entire device, is striking.

Neuralink has thought through the challenge of developing a clinically viable BMI from beginning to end in a way that few groups have done, though they acknowledge that many challenges remain as they work towards getting this technology into human patients in the clinic.

Figuring Out What More Electrodes Gets You
The quest for implantable devices with thousands of electrodes is not only the domain of private companies. DARPA, the NIH BRAIN Initiative, and international consortiums are working on neurotechnologies for recording and stimulating in the brain with goals of tens of thousands of electrodes. But what might scientists do with the information from 1,000, 3,000, or maybe even 100,000 neurons?

At some level, devices with more electrodes might not actually be necessary to have a meaningful impact in people’s lives. Effective control of computers for access and communication, of robotic limbs to grasp and move objects as well as of paralyzed muscles is already happening—in people. And it has been for a number of years.

Since the 1990s, the Utah Array, which has just 100 electrodes and is manufactured by Blackrock Microsystems, has been a critical device in neuroscience and clinical research. This electrode array is FDA-cleared for temporary neural recording. Several research groups, including our own, have implanted Utah Arrays in people that lasted multiple years.

Currently, the biggest constraints are related to connectors, electronics, and system-level engineering, not the implanted electrode itself—although increasing the electrodes’ lifespan to more than five years would represent a significant advance. As those technical capabilities improve, it might turn out that the ability to accurately control computers and robots is limited more by scientists’ understanding of what the neurons are saying—that is, the neural code—than by the number of electrodes on the device.

Even the most capable implanted system, and maybe the most capable devices researchers can reasonably imagine, might fall short of the goal of actually augmenting skilled human performance. Nevertheless, Neuralink’s goal of creating better BMIs has the potential to improve the lives of people who can’t move or are unable to communicate. Right now, Musk’s vision of using BMIs to meld physical brains and intelligence with artificial ones is no more than a dream.

So, what does the future look like for Neuralink and other groups creating implantable BMIs? Devices with more electrodes that last longer and are connected to smaller and more powerful wireless electronics are essential. Better devices themselves, however, are insufficient. Continued public and private investment in companies and academic research labs, as well as innovative ways for these groups to work together to share technologies and data, will be necessary to truly advance scientists’ understanding of the brain and deliver on the promise of BMIs to improve peoples’ lives.

While researchers need to keep the future societal implications of advanced neurotechnologies in mind—there’s an essential role for ethicists and regulation—BMIs could be truly transformative as they help more people overcome limitations caused by injury or disease in the brain and body.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Image Credit: UPMC/Pitt Health Sciences, / CC BY-NC-ND Continue reading

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#435231 Team programs a humanoid robot to ...

For a robot to be able to “learn” sign language, it is necessary to combine different areas of engineering such as artificial intelligence, neural networks and artificial vision, as well as underactuated robotic hands. “One of the main new developments of this research is that we united two major areas of Robotics: complex systems (such as robotic hands) and social interaction and communication,” explains Juan Víctores, one of the researchers from the Robotics Lab in the Department of Systems Engineering and Automation of the UC3M. Continue reading

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#435219 For less than $200, engineering students ...

Mechanical engineering students challenged themselves to make a robotic fish that not only swims like a real fish, but looks the part too, demonstrating the possibilities inherent to soft robotics. Continue reading

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#435172 DARPA’s New Project Is Investing ...

When Elon Musk and DARPA both hop aboard the cyborg hypetrain, you know brain-machine interfaces (BMIs) are about to achieve the impossible.

BMIs, already the stuff of science fiction, facilitate crosstalk between biological wetware with external computers, turning human users into literal cyborgs. Yet mind-controlled robotic arms, microelectrode “nerve patches”, or “memory Band-Aids” are still purely experimental medical treatments for those with nervous system impairments.

With the Next-Generation Nonsurgical Neurotechnology (N3) program, DARPA is looking to expand BMIs to the military. This month, the project tapped six academic teams to engineer radically different BMIs to hook up machines to the brains of able-bodied soldiers. The goal is to ditch surgery altogether—while minimizing any biological interventions—to link up brain and machine.

Rather than microelectrodes, which are currently surgically inserted into the brain to hijack neural communication, the project is looking to acoustic signals, electromagnetic waves, nanotechnology, genetically-enhanced neurons, and infrared beams for their next-gen BMIs.

It’s a radical departure from current protocol, with potentially thrilling—or devastating—impact. Wireless BMIs could dramatically boost bodily functions of veterans with neural damage or post-traumatic stress disorder (PTSD), or allow a single soldier to control swarms of AI-enabled drones with his or her mind. Or, similar to the Black Mirror episode Men Against Fire, it could cloud the perception of soldiers, distancing them from the emotional guilt of warfare.

When trickled down to civilian use, these new technologies are poised to revolutionize medical treatment. Or they could galvanize the transhumanist movement with an inconceivably powerful tool that fundamentally alters society—for better or worse.

Here’s what you need to know.

Radical Upgrades
The four-year N3 program focuses on two main aspects: noninvasive and “minutely” invasive neural interfaces to both read and write into the brain.

Because noninvasive technologies sit on the scalp, their sensors and stimulators will likely measure entire networks of neurons, such as those controlling movement. These systems could then allow soldiers to remotely pilot robots in the field—drones, rescue bots, or carriers like Boston Dynamics’ BigDog. The system could even boost multitasking prowess—mind-controlling multiple weapons at once—similar to how able-bodied humans can operate a third robotic arm in addition to their own two.

In contrast, minutely invasive technologies allow scientists to deliver nanotransducers without surgery: for example, an injection of a virus carrying light-sensitive sensors, or other chemical, biotech, or self-assembled nanobots that can reach individual neurons and control their activity independently without damaging sensitive tissue. The proposed use for these technologies isn’t yet well-specified, but as animal experiments have shown, controlling the activity of single neurons at multiple points is sufficient to program artificial memories of fear, desire, and experiences directly into the brain.

“A neural interface that enables fast, effective, and intuitive hands-free interaction with military systems by able-bodied warfighters is the ultimate program goal,” DARPA wrote in its funding brief, released early last year.

The only technologies that will be considered must have a viable path toward eventual use in healthy human subjects.

“Final N3 deliverables will include a complete integrated bidirectional brain-machine interface system,” the project description states. This doesn’t just include hardware, but also new algorithms tailored to these system, demonstrated in a “Department of Defense-relevant application.”

The Tools
Right off the bat, the usual tools of the BMI trade, including microelectrodes, MRI, or transcranial magnetic stimulation (TMS) are off the table. These popular technologies rely on surgery, heavy machinery, or personnel to sit very still—conditions unlikely in the real world.

The six teams will tap into three different kinds of natural phenomena for communication: magnetism, light beams, and acoustic waves.

Dr. Jacob Robinson at Rice University, for example, is combining genetic engineering, infrared laser beams, and nanomagnets for a bidirectional system. The $18 million project, MOANA (Magnetic, Optical and Acoustic Neural Access device) uses viruses to deliver two extra genes into the brain. One encodes a protein that sits on top of neurons and emits infrared light when the cell activates. Red and infrared light can penetrate through the skull. This lets a skull cap, embedded with light emitters and detectors, pick up these signals for subsequent decoding. Ultra-fast and utra-sensitvie photodetectors will further allow the cap to ignore scattered light and tease out relevant signals emanating from targeted portions of the brain, the team explained.

The other new gene helps write commands into the brain. This protein tethers iron nanoparticles to the neurons’ activation mechanism. Using magnetic coils on the headset, the team can then remotely stimulate magnetic super-neurons to fire while leaving others alone. Although the team plans to start in cell cultures and animals, their goal is to eventually transmit a visual image from one person to another. “In four years we hope to demonstrate direct, brain-to-brain communication at the speed of thought and without brain surgery,” said Robinson.

Other projects in N3 are just are ambitious.

The Carnegie Mellon team, for example, plans to use ultrasound waves to pinpoint light interaction in targeted brain regions, which can then be measured through a wearable “hat.” To write into the brain, they propose a flexible, wearable electrical mini-generator that counterbalances the noisy effect of the skull and scalp to target specific neural groups.

Similarly, a group at Johns Hopkins is also measuring light path changes in the brain to correlate them with regional brain activity to “read” wetware commands.

The Teledyne Scientific & Imaging group, in contrast, is turning to tiny light-powered “magnetometers” to detect small, localized magnetic fields that neurons generate when they fire, and match these signals to brain output.

The nonprofit Battelle team gets even fancier with their ”BrainSTORMS” nanotransducers: magnetic nanoparticles wrapped in a piezoelectric shell. The shell can convert electrical signals from neurons into magnetic ones and vice-versa. This allows external transceivers to wirelessly pick up the transformed signals and stimulate the brain through a bidirectional highway.

The magnetometers can be delivered into the brain through a nasal spray or other non-invasive methods, and magnetically guided towards targeted brain regions. When no longer needed, they can once again be steered out of the brain and into the bloodstream, where the body can excrete them without harm.

Four-Year Miracle
Mind-blown? Yeah, same. However, the challenges facing the teams are enormous.

DARPA’s stated goal is to hook up at least 16 sites in the brain with the BMI, with a lag of less than 50 milliseconds—on the scale of average human visual perception. That’s crazy high resolution for devices sitting outside the brain, both in space and time. Brain tissue, blood vessels, and the scalp and skull are all barriers that scatter and dissipate neural signals. All six teams will need to figure out the least computationally-intensive ways to fish out relevant brain signals from background noise, and triangulate them to the appropriate brain region to decipher intent.

In the long run, four years and an average $20 million per project isn’t much to potentially transform our relationship with machines—for better or worse. DARPA, to its credit, is keenly aware of potential misuse of remote brain control. The program is under the guidance of a panel of external advisors with expertise in bioethical issues. And although DARPA’s focus is on enabling able-bodied soldiers to better tackle combat challenges, it’s hard to argue that wireless, non-invasive BMIs will also benefit those most in need: veterans and other people with debilitating nerve damage. To this end, the program is heavily engaging the FDA to ensure it meets safety and efficacy regulations for human use.

Will we be there in just four years? I’m skeptical. But these electrical, optical, acoustic, magnetic, and genetic BMIs, as crazy as they sound, seem inevitable.

“DARPA is preparing for a future in which a combination of unmanned systems, AI, and cyber operations may cause conflicts to play out on timelines that are too short for humans to effectively manage with current technology alone,” said Al Emondi, the N3 program manager.

The question is, now that we know what’s in store, how should the rest of us prepare?

Image Credit: With permission from DARPA N3 project. Continue reading

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#435167 A Closer Look at the Robots Helping Us ...

Buck Rogers had Twiki. Luke Skywalker palled around with C-3PO and R2-D2. And astronauts aboard the International Space Station (ISS) now have their own robotic companions in space—Astrobee.

A pair of the cube-shaped robots were launched to the ISS during an April re-supply mission and are currently being commissioned for use on the space station. The free-flying space robots, dubbed Bumble and Honey, are the latest generation of robotic machines to join the human crew on the ISS.

Exploration of the solar system and beyond will require autonomous machines that can assist humans with numerous tasks—or go where we cannot. NASA has said repeatedly that robots will be instrumental in future space missions to the moon, Mars, and even to the icy moon Europa.

The Astrobee robots will specifically test robotic capabilities in zero gravity, replacing the SPHERES (Synchronized Position Hold, Engage, Reorient, Experimental Satellite) robots that have been on the ISS for more than a decade to test various technologies ranging from communications to navigation.

The 18-sided robots, each about the size of a volleyball or an oversized Dungeons and Dragons die, use CO2-based cold-gas thrusters for movement and a series of ultrasonic beacons for orientation. The Astrobee robots, on the other hand, can propel themselves autonomously around the interior of the ISS using electric fans and six cameras.

The modular design of the Astrobee robots means they are highly plug-and-play, capable of being reconfigured with different hardware modules. The robots’ software is also open-source, encouraging scientists and programmers to develop and test new algorithms and features.

And, yes, the Astrobee robots will be busy as bees once they are fully commissioned this fall, with experiments planned to begin next year. Scientists hope to learn more about how robots can assist space crews and perform caretaking duties on spacecraft.

Robots Working Together
The Astrobee robots are expected to be joined by a familiar “face” on the ISS later this year—the humanoid robot Robonaut.

Robonaut, also known as R2, was the first US-built robot on the ISS. It joined the crew back in 2011 without legs, which were added in 2014. However, the installation never entirely worked, as R2 experienced power failures that eventually led to its return to Earth last year to fix the problem. If all goes as planned, the space station’s first humanoid robot will return to the ISS to lend a hand to the astronauts and the new robotic arrivals.

In particular, NASA is interested in how the two different robotic platforms can complement each other, with an eye toward outfitting the agency’s proposed lunar orbital space station with various robots that can supplement a human crew.

“We don’t have definite plans for what would happen on the Gateway yet, but there’s a general recognition that intra-vehicular robots are important for space stations,” Astrobee technical lead Trey Smith in the NASA Intelligent Robotics Group told IEEE Spectrum. “And so, it would not be surprising to see a mobile manipulator like Robonaut, and a free flyer like Astrobee, on the Gateway.”

While the focus on R2 has been to test its capabilities in zero gravity and to use it for mundane or dangerous tasks in space, the technology enabling the humanoid robot has proven to be equally useful on Earth.

For example, R2 has amazing dexterity for a robot, with sensors, actuators, and tendons comparable to the nerves, muscles, and tendons in a human hand. Based on that design, engineers are working on a robotic glove that can help factory workers, for instance, do their jobs better while reducing the risk of repetitive injuries. R2 has also inspired development of a robotic exoskeleton for both astronauts in space and paraplegics on Earth.

Working Hard on Soft Robotics
While innovative and technologically sophisticated, Astrobee and Robonaut are typical robots in that neither one would do well in a limbo contest. In other words, most robots are limited in their flexibility and agility based on current hardware and materials.

A subfield of robotics known as soft robotics involves developing robots with highly pliant materials that mimic biological organisms in how they move. Scientists at NASA’s Langley Research Center are investigating how soft robots could help with future space exploration.

Specifically, the researchers are looking at a series of properties to understand how actuators—components responsible for moving a robotic part, such as Robonaut’s hand—can be built and used in space.

The team first 3D prints a mold and then pours a flexible material like silicone into the mold. Air bladders or chambers in the actuator expand and compress using just air.

Some of the first applications of soft robotics sound more tool-like than R2-D2-like. For example, two soft robots could connect to produce a temporary shelter for astronauts on the moon or serve as an impromptu wind shield during one of Mars’ infamous dust storms.

The idea is to use soft robots in situations that are “dangerous, dirty, or dull,” according to Jack Fitzpatrick, a NASA intern working on the soft robotics project at Langley.

Working on Mars
Of course, space robots aren’t only designed to assist humans. In many instances, they are the only option to explore even relatively close celestial bodies like Mars. Four American-made robotic rovers have been used to investigate the fourth planet from the sun since 1997.

Opportunity is perhaps the most famous, covering about 25 miles of terrain across Mars over 15 years. A dust storm knocked it out of commission last year, with NASA officially ending the mission in February.

However, the biggest and baddest of the Mars rovers, Curiosity, is still crawling across the Martian surface, sending back valuable data since 2012. The car-size robot carries 17 cameras, a laser to vaporize rocks for study, and a drill to collect samples. It is on the hunt for signs of biological life.

The next year or two could see a virtual traffic jam of robots to Mars. NASA’s Mars 2020 Rover is next in line to visit the Red Planet, sporting scientific gadgets like an X-ray fluorescence spectrometer for chemical analyses and ground-penetrating radar to see below the Martian surface.

This diagram shows the instrument payload for the Mars 2020 mission. Image Credit: NASA.
Meanwhile, the Europeans have teamed with the Russians on a rover called Rosalind Franklin, named after a famed British chemist, that will drill down into the Martian ground for evidence of past or present life as soon as 2021.

The Chinese are also preparing to begin searching for life on Mars using robots as soon as next year, as part of the country’s Mars Global Remote Sensing Orbiter and Small Rover program. The mission is scheduled to be the first in a series of launches that would culminate with bringing samples back from Mars to Earth.

Perhaps there is no more famous utterance in the universe of science fiction as “to boldly go where no one has gone before.” However, the fact is that human exploration of the solar system and beyond will only be possible with robots of different sizes, shapes, and sophistication.

Image Credit: NASA. Continue reading

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