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#435575 How an AI Startup Designed a Drug ...

Posted on September 9, 2019 by Android

Discovering a new drug can take decades, billions of dollars, and untold man hours from some of the smartest people on the planet. Now a startup says it’s taken a significant step towards speeding the process up using AI.

The typical drug discovery process involves carrying out physical tests on enormous libraries of molecules, and even with the help of robotics it’s an arduous process. The idea of sidestepping this by using computers to virtually screen for promising candidates has been around for decades. But progress has been underwhelming, and it’s still not a major part of commercial pipelines.

Recent advances in deep learning, however, have reignited hopes for the field, and major pharma companies have started tying up with AI-powered drug discovery startups. And now Insilico Medicine has used AI to design a molecule that effectively targets a protein involved in fibrosis—the formation of excess fibrous tissue—in mice in just 46 days.

The platform the company has developed combines two of the hottest sub-fields of AI: the generative adversarial networks, or GANs, which power deepfakes, and reinforcement learning, which is at the heart of the most impressive game-playing AI advances of recent years.

In a paper in Nature Biotechnology, the company’s researchers describe how they trained their model on all the molecules already known to target this protein as well as many other active molecules from various datasets. The model was then used to generate 30,000 candidate molecules.

Unlike most previous efforts, they went a step further and selected the most promising molecules for testing in the lab. The 30,000 candidates were whittled down to just 6 using more conventional drug discovery approaches and were then synthesized in the lab. They were put through increasingly stringent tests, but the leading candidate was found to be effective at targeting the desired protein and behaved as one would hope a drug would.

The authors are clear that the results are just a proof-of-concept, which company CEO Alex Zhavoronkov told Wired stemmed from a challenge set by a pharma partner to design a drug as quickly as possible. But they say they were able to carry out the process faster than traditional methods for a fraction of the cost.

There are some caveats. For a start, the protein being targeted is already very well known and multiple effective drugs exist for it. That gave the company a wealth of data to train their model on, something that isn’t the case for many of the diseases where we urgently need new drugs.

The company’s platform also only targets the very initial stages of the drug discovery process. The authors concede in their paper that the molecules would still take considerable optimization in the lab before they’d be true contenders for clinical trials.

“And that is where you will start to begin to commence to spend the vast piles of money that you will eventually go through in trying to get a drug to market,” writes Derek Lowe in his blog In The Pipeline. The part of the discovery process that the platform tackles represents a tiny fraction of the total cost of drug development, he says.

Nonetheless, the research is a definite advance for virtual screening technology and an important marker of the potential of AI for designing new medicines. Zhavoronkov also told Wired that this research was done more than a year ago, and they’ve since adapted the platform to go after harder drug targets with less data.

And with big pharma companies desperate to slash their ballooning development costs and find treatments for a host of intractable diseases, they can use all the help they can get.

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#435528 The Time for AI Is Now. Here’s Why

Posted on August 21, 2019 by Android

You hear a lot these days about the sheer transformative power of AI.

There’s pure intelligence: DeepMind’s algorithms readily beat humans at Go and StarCraft, and DeepStack triumphs over humans at no-limit hold’em poker. Often, these silicon brains generate gameplay strategies that don’t resemble anything from a human mind.

There’s astonishing speed: algorithms routinely surpass radiologists in diagnosing breast cancer, eye disease, and other ailments visible from medical imaging, essentially collapsing decades of expert training down to a few months.

Although AI’s silent touch is mainly felt today in the technological, financial, and health sectors, its impact across industries is rapidly spreading. At the Singularity University Global Summit in San Francisco this week Neil Jacobstein, Chair of AI and Robotics, painted a picture of a better AI-powered future for humanity that is already here.

Thanks to cloud-based cognitive platforms, sophisticated AI tools like deep learning are no longer relegated to academic labs. For startups looking to tackle humanity’s grand challenges, the tools to efficiently integrate AI into their missions are readily available. The progress of AI is massively accelerating—to the point you need help from AI to track its progress, joked Jacobstein.

Now is the time to consider how AI can impact your industry, and in the process, begin to envision a beneficial relationship with our machine coworkers. As Jacobstein stressed in his talk, the future of a brain-machine mindmeld is a collaborative intelligence that augments our own. “AI is reinventing the way we invent,” he said.

AI’s Rapid Revolution
Machine learning and other AI-based methods may seem academic and abstruse. But Jacobstein pointed out that there are already plenty of real-world AI application frameworks.

Their secret? Rather than coding from scratch, smaller companies—with big visions—are tapping into cloud-based solutions such as Google’s TensorFlow, Microsoft’s Azure, or Amazon’s AWS to kick off their AI journey. These platforms act as all-in-one solutions that not only clean and organize data, but also contain built-in security and drag-and-drop coding that allow anyone to experiment with complicated machine learning algorithms.

Google Cloud’s Anthos, for example, lets anyone migrate data from other servers—IBM Watson or AWS, for example—so users can leverage different computing platforms and algorithms to transform data into insights and solutions.

Rather than coding from scratch, it’s already possible to hop onto a platform and play around with it, said Jacobstein. That’s key: this democratization of AI is how anyone can begin exploring solutions to problems we didn’t even know we had, or those long thought improbable.

The acceleration is only continuing. Much of AI’s mind-bending pace is thanks to a massive infusion of funding. Microsoft recently injected $1 billion into OpenAI, the Elon Musk venture that engineers socially responsible artificial general intelligence (AGI).

The other revolution is in hardware, and Google, IBM, and NVIDIA—among others—are racing to manufacture computing chips tailored to machine learning.

Democratizing AI is like the birth of the printing press. Mechanical printing allowed anyone to become an author; today, an iPhone lets anyone film a movie masterpiece.

However, this diffusion of AI into the fabric of our lives means tech explorers need to bring skepticism to their AI solutions, giving them a dose of empathy, nuance, and humanity.

A Path Towards Ethical AI
The democratization of AI is a double-edged sword: as more people wield the technology’s power in real-world applications, problems embedded in deep learning threaten to disrupt those very judgment calls.

Much of the press on the dangers of AI focuses on superintelligence—AI that’s more adept at learning than humans—taking over the world, said Jacobstein. But the near-term threat, and far more insidious, is in humans misusing the technology.

Deepfakes, for example, allow AI rookies to paste one person’s head on a different body or put words into a person’s mouth. As the panel said, it pays to think of AI as a cybersecurity problem, one with currently shaky accountability and complexity, and one that fails at diversity and bias.

Take bias. Thanks to progress in natural language processing, Google Translate works nearly perfectly today, so much so that many consider the translation problem solved. Not true, the panel said. One famous example is how the algorithm translates gender-neutral terms like “doctor” into “he” and “nurse” into “she.”

These biases reflect our own, and it’s not just a data problem. To truly engineer objective AI systems, ones stripped of our society’s biases, we need to ask who is developing these systems, and consult those who will be impacted by the products. In addition to gender, racial bias is also rampant. For example, one recent report found that a supposedly objective crime-predicting system was trained on falsified data, resulting in outputs that further perpetuate corrupt police practices. Another study from Google just this month found that their hate speech detector more often labeled innocuous tweets from African-Americans as “obscene” compared to tweets from people of other ethnicities.

We often think of building AI as purely an engineering job, the panelists agreed. But similar to gene drives, germ-line genome editing, and other transformative—but dangerous—tools, AI needs to grow under the consultation of policymakers and other stakeholders. It pays to start young: educating newer generations on AI biases will mold malleable minds early, alerting them to the problem of bias and potentially mitigating risks.

As panelist Tess Posner from AI4ALL said, AI is rocket fuel for ambition. If young minds set out using the tools of AI to tackle their chosen problems, while fully aware of its inherent weaknesses, we can begin to build an AI-embedded future that is widely accessible and inclusive.

The bottom line: people who will be impacted by AI need to be in the room at the conception of an AI solution. People will be displaced by the new technology, and ethical AI has to consider how to mitigate human suffering during the transition. Just because AI looks like “magic fairy dust doesn’t mean that you’re home free,” the panelists said. You, the sentient human, bear the burden of being responsible for how you decide to approach the technology.

The time for AI is now. Let’s make it ethical.

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#435494 Driverless Electric Trucks Are Coming, ...

Posted on August 14, 2019 by Android

Self-driving and electric cars just don’t stop making headlines lately. Amazon invested in self-driving startup Aurora earlier this year. Waymo, Daimler, GM, along with startups like Zoox, have all launched or are planning to launch driverless taxis, many of them all-electric. People are even yanking driverless cars from their timeless natural habitat—roads—to try to teach them to navigate forests and deserts.

The future of driving, it would appear, is upon us.

But an equally important vehicle that often gets left out of the conversation is trucks; their relevance to our day-to-day lives may not be as visible as that of cars, but their impact is more profound than most of us realize.

Two recent developments in trucking point to a future of self-driving, electric semis hauling goods across the country, and likely doing so more quickly, cheaply, and safely than trucks do today.

Self-Driving in Texas
Last week, Kodiak Robotics announced it’s beginning its first commercial deliveries using self-driving trucks on a route from Dallas to Houston. The two cities sit about 240 miles apart, connected primarily by interstate 45. Kodiak is aiming to expand its reach far beyond the heart of Texas (if Dallas and Houston can be considered the heart, that is) to the state’s most far-flung cities, including El Paso to the west and Laredo to the south.

If self-driving trucks are going to be constrained to staying within state lines (and given that the laws regulating them differ by state, they will be for the foreseeable future), Texas is a pretty ideal option. It’s huge (thousands of miles of highway run both east-west and north-south), it’s warm (better than cold for driverless tech components like sensors), its proximity to Mexico means constant movement of both raw materials and manufactured goods (basically, you can’t have too many trucks in Texas), and most crucially, it’s lax on laws (driverless vehicles have been permitted there since 2017).

Spoiler, though—the trucks won’t be fully unmanned. They’ll have safety drivers to guide them onto and off of the highway, and to be there in case of any unexpected glitches.

California Goes (Even More) Electric
According to some top executives in the rideshare industry, automation is just one key component of the future of driving. Another is electricity replacing gas, and it’s not just carmakers that are plugging into the trend.

This week, Daimler Trucks North America announced completion of its first electric semis for customers Penske and NFI, to be used in the companies’ southern California operations. Scheduled to start operating later this month, the trucks will essentially be guinea pigs for testing integration of electric trucks into large-scale fleets; intel gleaned from the trucks’ performance will impact the design of later models.

Design-wise, the trucks aren’t much different from any other semi you’ve seen lumbering down the highway recently. Their range is about 250 miles—not bad if you think about how much more weight a semi is pulling than a passenger sedan—and they’ve been dubbed eCascadia, an electrified version of Freightliner’s heavy-duty Cascadia truck.

Batteries have a long way to go before they can store enough energy to make electric trucks truly viable (not to mention setting up a national charging infrastructure), but Daimler’s announcement is an important step towards an electrically-driven future.

Keep on Truckin’
Obviously, it’s more exciting to think about hailing one of those cute little Waymo cars with no steering wheel to shuttle you across town than it is to think about that 12-pack of toilet paper you ordered on Amazon cruising down the highway in a semi while the safety driver takes a snooze. But pushing driverless and electric tech in the trucking industry makes sense for a few big reasons.

Trucks mostly run long routes on interstate highways—with no pedestrians, stoplights, or other city-street obstacles to contend with, highway driving is much easier to automate. What glitches there are to be smoothed out may as well be smoothed out with cargo on board rather than people. And though you wouldn’t know it amid the frantic shouts of ‘a robot could take your job!’, the US is actually in the midst of a massive shortage of truck drivers—60,000 short as of earlier this year, to be exact.

As Todd Spencer, president of the Owner-Operator Independent Drivers Association, put it, “Trucking is an absolutely essential, critical industry to the nation, to everybody in it.” Alas, trucks get far less love than cars, but come on—probably 90 percent of the things you ate, bought, or used today were at some point moved by a truck.

Adding driverless and electric tech into that equation, then, should yield positive outcomes on all sides, whether we’re talking about cheaper 12-packs of toilet paper, fewer traffic fatalities due to human error, a less-strained labor force, a stronger economy… or something pretty cool to see as you cruise down the highway in your (driverless, electric, futuristic) car.

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#435436 Undeclared Wars in Cyberspace Are ...

Posted on August 1, 2019 by Android

The US is at war. That’s probably not exactly news, as the country has been engaged in one type of conflict or another for most of its history. The last time we officially declared war was after Japan bombed Pearl Harbor in December 1941.

Our biggest undeclared war today is not being fought by drones in the mountains of Afghanistan or even through the less-lethal barrage of threats over the nuclear programs in North Korea and Iran. In this particular war, it is the US that is under attack and on the defensive.

This is cyberwarfare.

The definition of what constitutes a cyber attack is a broad one, according to Greg White, executive director of the Center for Infrastructure Assurance and Security (CIAS) at The University of Texas at San Antonio (UTSA).

At the level of nation-state attacks, cyberwarfare could involve “attacking systems during peacetime—such as our power grid or election systems—or it could be during war time in which case the attacks may be designed to cause destruction, damage, deception, or death,” he told Singularity Hub.

For the US, the Pearl Harbor of cyberwarfare occurred during 2016 with the Russian interference in the presidential election. However, according to White, an Air Force veteran who has been involved in computer and network security since 1986, the history of cyber war can be traced back much further, to at least the first Gulf War of the early 1990s.

“We started experimenting with cyber attacks during the first Gulf War, so this has been going on a long time,” he said. “Espionage was the prime reason before that. After the war, the possibility of expanding the types of targets utilized expanded somewhat. What is really interesting is the use of social media and things like websites for [psychological operation] purposes during a conflict.”

The 2008 conflict between Russia and the Republic of Georgia is often cited as a cyberwarfare case study due to the large scale and overt nature of the cyber attacks. Russian hackers managed to bring down more than 50 news, government, and financial websites through denial-of-service attacks. In addition, about 35 percent of Georgia’s internet networks suffered decreased functionality during the attacks, coinciding with the Russian invasion of South Ossetia.

The cyberwar also offers lessons for today on Russia’s approach to cyberspace as a tool for “holistic psychological manipulation and information warfare,” according to a 2018 report called Understanding Cyberwarfare from the Modern War Institute at West Point.

US Fights Back
News in recent years has highlighted how Russian hackers have attacked various US government entities and critical infrastructure such as energy and manufacturing. In particular, a shadowy group known as Unit 26165 within the country’s military intelligence directorate is believed to be behind the 2016 US election interference campaign.

However, the US hasn’t been standing idly by. Since at least 2012, the US has put reconnaissance probes into the control systems of the Russian electric grid, The New York Times reported. More recently, we learned that the US military has gone on the offensive, putting “crippling malware” inside the Russian power grid as the U.S. Cyber Command flexes its online muscles thanks to new authority granted to it last year.

“Access to the power grid that is obtained now could be used to shut something important down in the future when we are in a war,” White noted. “Espionage is part of the whole program. It is important to remember that cyber has just provided a new domain in which to conduct the types of activities we have been doing in the real world for years.”

The US is also beginning to pour more money into cybersecurity. The 2020 fiscal budget calls for spending $17.4 billion throughout the government on cyber-related activities, with the Department of Defense (DoD) alone earmarked for $9.6 billion.

Despite the growing emphasis on cybersecurity in the US and around the world, the demand for skilled security professionals is well outpacing the supply, with a projected shortfall of nearly three million open or unfilled positions according to the non-profit IT security organization (ISC)².

UTSA is rare among US educational institutions in that security courses and research are being conducted across three different colleges, according to White. About 10 percent of the school’s 30,000-plus students are enrolled in a cyber-related program, he added, and UTSA is one of only 21 schools that has received the Cyber Operations Center of Excellence designation from the National Security Agency.

“This track in the computer science program is specifically designed to prepare students for the type of jobs they might be involved in if they went to work for the DoD,” White said.

However, White is extremely doubtful there will ever be enough cyber security professionals to meet demand. “I’ve been preaching that we’ve got to worry about cybersecurity in the workforce, not just the cybersecurity workforce, not just cybersecurity professionals. Everybody has a responsibility for cybersecurity.”

Artificial Intelligence in Cybersecurity
Indeed, humans are often seen as the weak link in cybersecurity. That point was driven home at a cybersecurity roundtable discussion during this year’s Brainstorm Tech conference in Aspen, Colorado.

Participant Dorian Daley, general counsel at Oracle, said insider threats are at the top of the list when it comes to cybersecurity. “Sadly, I think some of the biggest challenges are people, and I mean that in a number of ways. A lot of the breaches really come from insiders. So the more that you can automate things and you can eliminate human malicious conduct, the better.”

White noted that automation is already the norm in cybersecurity. “Humans can’t react as fast as systems can launch attacks, so we need to rely on automated defenses as well,” he said. “This doesn’t mean that humans are not in the loop, but much of what is done these days is ‘scripted’.”

The use of artificial intelligence, machine learning, and other advanced automation techniques have been part of the cybersecurity conversation for quite some time, according to White, such as pattern analysis to look for specific behaviors that might indicate an attack is underway.

“What we are seeing quite a bit of today falls under the heading of big data and data analytics,” he explained.

But there are signs that AI is going off-script when it comes to cyber attacks. In the hands of threat groups, AI applications could lead to an increase in the number of cyberattacks, wrote Michelle Cantos, a strategic intelligence analyst at cybersecurity firm FireEye.

“Current AI technology used by businesses to analyze consumer behavior and find new customer bases can be appropriated to help attackers find better targets,” she said. “Adversaries can use AI to analyze datasets and generate recommendations for high-value targets they think the adversary should hit.”

In fact, security researchers have already demonstrated how a machine learning system could be used for malicious purposes. The Social Network Automated Phishing with Reconnaissance system, or SNAP_R, generated more than four times as many spear-phishing tweets on Twitter than a human—and was just as successful at targeting victims in order to steal sensitive information.

Cyber war is upon us. And like the current war on terrorism, there are many battlefields from which the enemy can attack and then disappear. While total victory is highly unlikely in the traditional sense, innovations through AI and other technologies can help keep the lights on against the next cyber attack.

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#435224 Can AI Save the Internet from Fake News?

Posted on June 30, 2019 by Android

There’s an old proverb that says “seeing is believing.” But in the age of artificial intelligence, it’s becoming increasingly difficult to take anything at face value—literally.

The rise of so-called “deepfakes,” in which different types of AI-based techniques are used to manipulate video content, has reached the point where Congress held its first hearing last month on the potential abuses of the technology. The congressional investigation coincided with the release of a doctored video of Facebook CEO Mark Zuckerberg delivering what appeared to be a sinister speech.

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Scientists are scrambling for solutions on how to combat deepfakes, while at the same time others are continuing to refine the techniques for less nefarious purposes, such as automating video content for the film industry.

At one end of the spectrum, for example, researchers at New York University’s Tandon School of Engineering have proposed implanting a type of digital watermark using a neural network that can spot manipulated photos and videos.

The idea is to embed the system directly into a digital camera. Many smartphone cameras and other digital devices already use AI to boost image quality and make other corrections. The authors of the study out of NYU say their prototype platform increased the chances of detecting manipulation from about 45 percent to more than 90 percent without sacrificing image quality.

On the other hand, researchers at Carnegie Mellon University recently hit on a technique for automatically and rapidly converting large amounts of video content from one source into the style of another. In one example, the scientists transferred the facial expressions of comedian John Oliver onto the bespectacled face of late night show host Stephen Colbert.

The CMU team says the method could be a boon to the movie industry, such as by converting black and white films to color, though it also conceded that the technology could be used to develop deepfakes.

Words Matter with Fake News
While the current spotlight is on how to combat video and image manipulation, a prolonged trench warfare on fake news is being fought by academia, nonprofits, and the tech industry.

This isn’t the fake news that some have come to use as a knee-jerk reaction to fact-based information that might be less than flattering to the subject of the report. Rather, fake news is deliberately-created misinformation that is spread via the internet.

In a recent Pew Research Center poll, Americans said fake news is a bigger problem than violent crime, racism, and terrorism. Fortunately, many of the linguistic tools that have been applied to determine when people are being deliberately deceitful can be baked into algorithms for spotting fake news.

That’s the approach taken by a team at the University of Michigan (U-M) to develop an algorithm that was better than humans at identifying fake news—76 percent versus 70 percent—by focusing on linguistic cues like grammatical structure, word choice, and punctuation.

For example, fake news tends to be filled with hyperbole and exaggeration, using terms like “overwhelming” or “extraordinary.”

“I think that’s a way to make up for the fact that the news is not quite true, so trying to compensate with the language that’s being used,” Rada Mihalcea, a computer science and engineering professor at U-M, told Singularity Hub.

The paper “Automatic Detection of Fake News” was based on the team’s previous studies on how people lie in general, without necessarily having the intention of spreading fake news, she said.

“Deception is a complicated and complex phenomenon that requires brain power,” Mihalcea noted. “That often results in simpler language, where you have shorter sentences or shorter documents.”

AI Versus AI
While most fake news is still churned out by humans with identifiable patterns of lying, according to Mihalcea, other researchers are already anticipating how to detect misinformation manufactured by machines.

A group led by Yejin Choi, with the Allen Institute of Artificial Intelligence and the University of Washington in Seattle, is one such team. The researchers recently introduced the world to Grover, an AI platform that is particularly good at catching autonomously-generated fake news because it’s equally good at creating it.

“This is due to a finding that is perhaps counterintuitive: strong generators for neural fake news are themselves strong detectors of it,” wrote Rowan Zellers, a PhD student and team member, in a Medium blog post. “A generator of fake news will be most familiar with its own peculiarities, such as using overly common or predictable words, as well as the peculiarities of similar generators.”

The team found that the best current discriminators can classify neural fake news from real, human-created text with 73 percent accuracy. Grover clocks in with 92 percent accuracy based on a training set of 5,000 neural network-generated fake news samples. Zellers wrote that Grover got better at scale, identifying 97.5 percent of made-up machine mumbo jumbo when trained on 80,000 articles.

It performed almost as well against fake news created by a powerful new text-generation system called GPT-2 built by OpenAI, a nonprofit research lab founded by Elon Musk, classifying 96.1 percent of the machine-written articles.

OpenAI had so feared that the platform could be abused that it has only released limited versions of the software. The public can play with a scaled-down version posted by a machine learning engineer named Adam King, where the user types in a short prompt and GPT-2 bangs out a short story or poem based on the snippet of text.

No Silver AI Bullet
While real progress is being made against fake news, the challenges of using AI to detect and correct misinformation are abundant, according to Hugo Williams, outreach manager for Logically, a UK-based startup that is developing different detectors using elements of deep learning and natural language processing, among others. He explained that the Logically models analyze information based on a three-pronged approach.

Publisher metadata: Is the article from a known, reliable, and trustworthy publisher with a history of credible journalism?
Network behavior: Is the article proliferating through social platforms and networks in ways typically associated with misinformation?
Content: The AI scans articles for hundreds of known indicators typically found in misinformation.

“There is no single algorithm which is capable of doing this,” Williams wrote in an email to Singularity Hub. “Even when you have a collection of different algorithms which—when combined—can give you relatively decent indications of what is unreliable or outright false, there will always need to be a human layer in the pipeline.”

The company released a consumer app in India back in February just before that country’s election cycle that was a “great testing ground” to refine its technology for the next app release, which is scheduled in the UK later this year. Users can submit articles for further scrutiny by a real person.

“We see our technology not as replacing traditional verification work, but as a method of simplifying and streamlining a very manual process,” Williams said. “In doing so, we’re able to publish more fact checks at a far quicker pace than other organizations.”

“With heightened analysis and the addition of more contextual information around the stories that our users are reading, we are not telling our users what they should or should not believe, but encouraging critical thinking based upon reliable, credible, and verified content,” he added.

AI may never be able to detect fake news entirely on its own, but it can help us be smarter about what we read on the internet.

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