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#437673 Can AI and Automation Deliver a COVID-19 ...

Posted on November 24, 2020 by Android

Illustration: Marysia Machulska

Within moments of meeting each other at a conference last year, Nathan Collins and Yann Gaston-Mathé began devising a plan to work together. Gaston-Mathé runs a startup that applies automated software to the design of new drug candidates. Collins leads a team that uses an automated chemistry platform to synthesize new drug candidates.

“There was an obvious synergy between their technology and ours,” recalls Gaston-Mathé, CEO and cofounder of Paris-based Iktos.

In late 2019, the pair launched a project to create a brand-new antiviral drug that would block a specific protein exploited by influenza viruses. Then the COVID-19 pandemic erupted across the world stage, and Gaston-Mathé and Collins learned that the viral culprit, SARS-CoV-2, relied on a protein that was 97 percent similar to their influenza protein. The partners pivoted.

Their companies are just two of hundreds of biotech firms eager to overhaul the drug-discovery process, often with the aid of artificial intelligence (AI) tools. The first set of antiviral drugs to treat COVID-19 will likely come from sifting through existing drugs. Remdesivir, for example, was originally developed to treat Ebola, and it has been shown to speed the recovery of hospitalized COVID-19 patients. But a drug made for one condition often has side effects and limited potency when applied to another. If researchers can produce an ­antiviral that specifically targets SARS-CoV-2, the drug would likely be safer and more effective than a repurposed drug.

There’s one big problem: Traditional drug discovery is far too slow to react to a pandemic. Designing a drug from scratch typically takes three to five years—and that’s before human clinical trials. “Our goal, with the combination of AI and automation, is to reduce that down to six months or less,” says Collins, who is chief strategy officer at SRI Biosciences, a division of the Silicon Valley research nonprofit SRI International. “We want to get this to be very, very fast.”

That sentiment is shared by small biotech firms and big pharmaceutical companies alike, many of which are now ramping up automated technologies backed by supercomputing power to predict, design, and test new antivirals—for this pandemic as well as the next—with unprecedented speed and scope.

“The entire industry is embracing these tools,” says Kara Carter, president of the International Society for Antiviral Research and executive vice president of infectious disease at Evotec, a drug-discovery company in Hamburg. “Not only do we need [new antivirals] to treat the SARS-CoV-2 infection in the population, which is probably here to stay, but we’ll also need them to treat future agents that arrive.”

There are currentlyabout 200 known viruses that infect humans. Although viruses represent less than 14 percent of all known human pathogens, they make up two-thirds of all new human pathogens discovered since 1980.

Antiviral drugs are fundamentally different from vaccines, which teach a person’s immune system to mount a defense against a viral invader, and antibody treatments, which enhance the body’s immune response. By contrast, anti­virals are chemical compounds that directly block a virus after a person has become infected. They do this by binding to specific proteins and preventing them from functioning, so that the virus cannot copy itself or enter or exit a cell.

The SARS-CoV-2 virus has an estimated 25 to 29 proteins, but not all of them are suitable drug targets. Researchers are investigating, among other targets, the virus’s exterior spike protein, which binds to a receptor on a human cell; two scissorlike enzymes, called proteases, that cut up long strings of viral proteins into functional pieces inside the cell; and a polymerase complex that makes the cell churn out copies of the virus’s genetic material, in the form of single-stranded RNA.

But it’s not enough for a drug candidate to simply attach to a target protein. Chemists also consider how tightly the compound binds to its target, whether it binds to other things as well, how quickly it metabolizes in the body, and so on. A drug candidate may have 10 to 20 such objectives. “Very often those objectives can appear to be anticorrelated or contradictory with each other,” says Gaston-Mathé.

Compared with antibiotics, antiviral drug discovery has proceeded at a snail’s pace. Scientists advanced from isolating the first antibacterial molecules in 1910 to developing an arsenal of powerful antibiotics by 1944. By contrast, it took until 1951 for researchers to be able to routinely grow large amounts of virus particles in cells in a dish, a breakthrough that earned the inventors a Nobel Prize in Medicine in 1954.

And the lag between the discovery of a virus and the creation of a treatment can be heartbreaking. According to the World Health Organization, 71 million people worldwide have chronic hepatitis C, a major cause of liver cancer. The virus that causes the infection was discovered in 1989, but effective antiviral drugs didn’t hit the market until 2014.

While many antibiotics work on a range of microbes, most antivirals are highly specific to a single virus—what those in the business call “one bug, one drug.” It takes a detailed understanding of a virus to develop an antiviral against it, says Che Colpitts, a virologist at Queen’s University, in Canada, who works on antivirals against RNA viruses. “When a new virus emerges, like SARS-CoV-2, we’re at a big disadvantage.”

Making drugs to stop viruses is hard for three main reasons. First, viruses are the Spartans of the pathogen world: They’re frugal, brutal, and expert at evading the human immune system. About 20 to 250 nanometers in diameter, viruses rely on just a few parts to operate, hijacking host cells to reproduce and often destroying those cells upon departure. They employ tricks to camouflage their presence from the host’s immune system, including preventing infected cells from sending out molecular distress beacons. “Viruses are really small, so they only have a few components, so there’s not that many drug targets available to start with,” says Colpitts.

Second, viruses replicate quickly, typically doubling in number in hours or days. This constant copying of their genetic material enables viruses to evolve quickly, producing mutations able to sidestep drug effects. The virus that causes AIDS soon develops resistance when exposed to a single drug. That’s why a cocktail of antiviral drugs is used to treat HIV infection.

Finally, unlike bacteria, which can exist independently outside human cells, viruses invade human cells to propagate, so any drug designed to eliminate a virus needs to spare the host cell. A drug that fails to distinguish between a virus and a cell can cause serious side effects. “Discriminating between the two is really quite difficult,” says Evotec’s Carter, who has worked in antiviral drug discovery for over three decades.

And then there’s the money barrier. Developing antivirals is rarely profitable. Health-policy researchers at the London School of Economics recently estimated that the average cost of developing a new drug is US $1 billion, and up to $2.8 billion for cancer and other specialty drugs. Because antivirals are usually taken for only short periods of time or during short outbreaks of disease, companies rarely recoup what they spent developing the drug, much less turn a profit, says Carter.

To change the status quo, drug discovery needs fresh approaches that leverage new technologies, rather than incremental improvements, says Christian Tidona, managing director of BioMed X, an independent research institute in Heidelberg, Germany. “We need breakthroughs.”

Putting Drug Development on Autopilot
Earlier this year, SRI Biosciences and Iktos began collaborating on a way to use artificial intelligence and automated chemistry to rapidly identify new drugs to target the COVID-19 virus. Within four months, they had designed and synthesized a first round of antiviral candidates. Here’s how they’re doing it.

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STEP 1: Iktos’s AI platform uses deep-learning algorithms in an iterative process to come up with new molecular structures likely to bind to and disable a specific coronavirus protein. Illustrations: Chris Philpot

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STEP 2: SRI Biosciences’s SynFini system is a three-part automated chemistry suite for producing new compounds. Starting with a target compound from Iktos, SynRoute uses machine learning to analyze and optimize routes for creating that compound, with results in about 10 seconds. It prioritizes routes based on cost, likelihood of success, and ease of implementation.

3/5

STEP 3: SynJet, an automated inkjet printer platform, tests the routes by printing out tiny quantities of chemical ingredients to see how they react. If the right compound is produced, the platform tests it.

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STEP 4: AutoSyn, an automated tabletop chemical plant, synthesizes milligrams to grams of the desired compound for further testing. Computer-selected “maps” dictate paths through the plant’s modular components.

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STEP 5: The most promising compounds are tested against live virus samples.

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Iktos’s AI platform was created by a medicinal chemist and an AI expert. To tackle SARS-CoV-2, the company used generative models—deep-learning algorithms that generate new data—to “imagine” molecular structures with a good chance of disabling a key coronavirus protein.

For a new drug target, the software proposes and evaluates roughly 1 million compounds, says Gaston-Mathé. It’s an iterative process: At each step, the system generates 100 virtual compounds, which are tested in silico with predictive models to see how closely they meet the objectives. The test results are then used to design the next batch of compounds. “It’s like we have a very, very fast chemist who is designing compounds, testing compounds, getting back the data, then designing another batch of compounds,” he says.

The computer isn’t as smart as a human chemist, Gaston-Mathé notes, but it’s much faster, so it can explore far more of what people in the field call “chemical space”—the set of all possible organic compounds. Unexplored chemical space is huge: Biochemists estimate that there are at least 1063 possible druglike molecules, and that 99.9 percent of all possible small molecules or compounds have never been synthesized.

Still, designing a chemical compound isn’t the hardest part of creating a new drug. After a drug candidate is designed, it must be synthesized, and the highly manual process for synthesizing a new chemical hasn’t changed much in 200 years. It can take days to plan a synthesis process and then months to years to optimize it for manufacture.

That’s why Gaston-Mathé was eager to send Iktos’s AI-generated designs to Collins’s team at SRI Biosciences. With $13.8 million from the Defense Advanced Research Projects Agency, SRI Biosciences spent the last four years automating the synthesis process. The company’s automated suite of three technologies, called SynFini, can produce new chemical compounds in just hours or days, says Collins.

First, machine-learning software devises possible routes for making a desired molecule. Next, an inkjet printer platform tests the routes by printing out and mixing tiny quantities of chemical ingredients to see how they react with one another; if the right compound is produced, the platform runs tests on it. Finally, a tabletop chemical plant synthesizes milligrams to grams of the desired compound.

Less than four months after Iktos and SRI Biosciences announced their collaboration, they had designed and synthesized a first round of antiviral candidates for SARS-CoV-2. Now they’re testing how well the compounds work on actual samples of the virus.

Out of 10
63 possible druglike molecules, 99.9 percent have never been synthesized.

Theirs isn’t the only collaborationapplying new tools to drug discovery. In late March, Alex Zhavoronkov, CEO of Hong Kong–based Insilico Medicine, came across a YouTube video showing three virtual-reality avatars positioning colorful, sticklike fragments in the side of a bulbous blue protein. The three researchers were using VR to explore how compounds might bind to a SARS-CoV-2 enzyme. Zhavoronkov contacted the startup that created the simulation—Nanome, in San Diego—and invited it to examine Insilico’s ­AI-generated molecules in virtual reality.

Insilico runs an AI platform that uses biological data to train deep-learning algorithms, then uses those algorithms to identify molecules with druglike features that will likely bind to a protein target. A four-day training sprint in late January yielded 100 molecules that appear to bind to an important SARS-CoV-2 protease. The company recently began synthesizing some of those molecules for laboratory testing.

Nanome’s VR software, meanwhile, allows researchers to import a molecular structure, then view and manipulate it on the scale of individual atoms. Like human chess players who use computer programs to explore potential moves, chemists can use VR to predict how to make molecules more druglike, says Nanome CEO Steve McCloskey. “The tighter the interface between the human and the computer, the more information goes both ways,” he says.

Zhavoronkov sent data about several of Insilico’s compounds to Nanome, which re-created them in VR. Nanome’s chemist demonstrated chemical tweaks to potentially improve each compound. “It was a very good experience,” says Zhavoronkov.

Meanwhile, in March, Takeda Pharmaceutical Co., of Japan, invited Schrödinger, a New York–based company that develops chemical-simulation software, to join an alliance working on antivirals. Schrödinger’s AI focuses on the physics of how proteins interact with small molecules and one another.

The software sifts through billions of molecules per week to predict a compound’s properties, and it optimizes for multiple desired properties simultaneously, says Karen Akinsanya, chief biomedical scientist and head of discovery R&D at Schrödinger. “There’s a huge sense of urgency here to come up with a potent molecule, but also to come up with molecules that are going to be well tolerated” by the body, she says. Drug developers are seeking compounds that can be broadly used and easily administered, such as an oral drug rather than an intravenous drug, she adds.

Schrödinger evaluated four protein targets and performed virtual screens for two of them, a computing-intensive process. In June, Google Cloud donated the equivalent of 16 million hours of Nvidia GPU time for the company’s calculations. Next, the alliance’s drug companies will synthesize and test the most promising compounds identified by the virtual screens.

Other companies, including Amazon Web Services, IBM, and Intel, as well as several U.S. national labs are also donating time and resources to the Covid-19 High Performance Computing Consortium. The consortium is supporting 87 projects, which now have access to 6.8 million CPU cores, 50,000 GPUs, and 600 petaflops of computational resources.

While advanced technologies could transform early drug discovery, any new drug candidate still has a long road after that. It must be tested in animals, manufactured in large batches for clinical trials, then tested in a series of trials that, for antivirals, lasts an average of seven years.

In May, the BioMed X Institute in Germany launched a five-year project to build a Rapid Antiviral Response Platform, which would speed drug discovery all the way through manufacturing for clinical trials. The €40 million ($47 million) project, backed by drug companies, will identify ­outside-the-box proposals from young scientists, then provide space and funding to develop their ideas.

“We’ll focus on technologies that allow us to go from identification of a new virus to 10,000 doses of a novel potential therapeutic ready for trials in less than six months,” says BioMed X’s Tidona, who leads the project.

While a vaccine will likely arrive long before a bespoke antiviral does, experts expect COVID-19 to be with us for a long time, so the effort to develop a direct-acting, potent antiviral continues. Plus, having new antivirals—and tools to rapidly create more—can only help us prepare for the next pandemic, whether it comes next month or in another 102 years.

“We’ve got to start thinking differently about how to be more responsive to these kinds of threats,” says Collins. “It’s pushing us out of our comfort zones.”

This article appears in the October 2020 print issue as “Automating Antivirals.” Continue reading →

Posted in Human Robots

#437643 Video Friday: Matternet Launches Urban ...

Posted on November 23, 2020 by Android

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

IROS 2020 – October 25-25, 2020 – [Online]
Bay Area Robotics Symposium – November 20, 2020 – [Online]
ACRA 2020 – December 8-10, 2020 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.

Sixteen teams chose their roster of virtual robots and sensor payloads, some based on real-life subterranean robots, and submitted autonomy and mapping algorithms that SubT Challenge officials then tested across eight cave courses in the cloud-based SubT Simulator. Their robots traversed the cave environments autonomously, without any input or adjustments from human operators. The Cave Circuit Virtual Competition teams earned points by correctly finding, identifying, and localizing up to 20 artifacts hidden in the cave courses within five-meter accuracy.

[ SubT ]

This year, the KUKA Innovation Award’s international jury of experts received a total of more than 40 ideas. The five finalist teams had time until November to implement their ideas. A KUKA LBR Med lightweight robot – the first robotic component to be certified for integration into a medical device – has been made available to them for this purpose. Beyond this, the teams have received a training for the hardware and coaching from KUKA experts throughout the competition. At virtual.MEDICA from 16-19.11.2020, the finalists presented their concepts to an international audience of experts and to the Innovation Award jury.

The winner of the KUKA Innovation Award 2020, worth 20,000 euros, is Team HIFUSK from the Scuola Superiore Sant'Anna in Italy.

[ KUKA Innovation Award ]

Like everything else the in-person Cybathlon event was cancelled, but the competition itself took place, just a little more distributed than it would have been otherwise.

[ Cybathlon ]

Matternet, developer of the world's leading urban drone logistics platform, today announced the launch of operations at Labor Berlin Charité Vivantes in Germany. The program kicked-off November 17, 2020 with permanent operations expected to take flight next year, creating the first urban BVLOS [Beyond Visual Line of Sight] medical drone delivery network in the European Union. The drone network expects to significantly improve the timeliness and efficiency of Labor Berlin’s diagnostics services by providing an option to avoid roadway delays, which will improve patient experience with potentially life-saving benefits and lower costs.

Routine BVLOS over an urban area? Impressive.

[ Matternet ]

Robots playing diabolo!

Thanks Thilo!

[ OMRON Sinic X]

Anki's tech has been repackaged into this robot that serves butter:

[ Butter Robot ]

Berkshire Grey just announced our Picking With Purpose Program in which we’ve partnered our robotic automation solutions with food rescue organizations City Harvest and The Greater Boston Food Bank to pick, pack, and distribute food to families in need in time for Thanksgiving. Berkshire Grey donated about 40,000 pounds of food, used one of our robotic automation systems to pick and pack that food into meal boxes for families in need, and our team members volunteered to run the system. City Harvest and The Greater Boston Food Bank are distributing the 4,000 meal boxes we produced. This is just the beginning. We are building a sponsorship program to make Picking With Purpose an ongoing initiative.

[ Berkshire Grey ]

Thanks Peter!

We posted a video previously of Cassie learning to skip, but here's a much more detailed look (accompanying an ICRA submission) that includes some very impressive stair descending.

[ DRL ]

From garage inventors to university students and entrepreneurs, NASA is looking for ideas on how to excavate the Moon’s icy regolith, or dirt, and deliver it to a hypothetical processing plant at the lunar South Pole. The NASA Break the Ice Lunar Challenge, a NASA Centennial Challenge, is now open for registration. The competition will take place over two phases and will reward new ideas and approaches for a system architecture capable of excavating and moving icy regolith and water on the lunar surface.

[ NASA ]

Adaptation to various scene configurations and object properties, stability and dexterity in robotic grasping manipulation is far from explored. This work presents an origami-based shape morphing fingertip design to actively tackle the grasping stability and dexterity problems. The proposed fingertip utilizes origami as its skeleton providing degrees of freedom at desired positions and motor-driven four-bar-linkages as its transmission components to achieve a compact size of the fingertip.

[ Paper ]

“If Roboy crashes… you die.”

[ Roboy ]

Traditionally lunar landers, as well as other large space exploration vehicles, are powered by solar arrays or small nuclear reactors. Rovers and small robots, however, are not big enough to carry their own dedicated power supplies and must be tethered to their larger counterparts via electrical cables. Tethering severely restricts mobility, and cables are prone to failure due to lunar dust (regolith) interfering with electrical contact points. Additionally, as robots become smaller and more complex, they are fitted with additional sensors that require more power, further exacerbating the problem. Lastly, solar arrays are not viable for charging during the lunar night. WiBotic is developing rapid charging systems and energy monitoring base stations for lunar robots, including the CubeRover – a shoebox-sized robot designed by Astrobotic – that will operate autonomously and charge wirelessly on the Moon.

[ WiBotic ]

Watching pick and place robots is my therapy.

[ Soft Robotics ]

It's really, really hard to beat liquid fuel for energy storage, as Quaternium demonstrates with their hybrid drone.

[ Quaternium ]

Thanks Gregorio!

State-of-the-art quadrotor simulators have a rigid and highly-specialized structure: either are they really fast, physically accurate, or photo-realistic. In this work, we propose a novel quadrotor simulator: Flightmare.

[ Flightmare ]

Drones that chuck fire-fighting balls into burning buildings, sure!

[ LARICS ]

If you missed ROS World, that's okay, because all of the talks are now online. Here's the opening keynote from Vivian Chu and Diligent robotics, along with a couple fun lightning talks.

[ ROS World 2020 ]

This week's CMU RI Seminar is by Chelsea Finn from Stanford University, on Data Scalability for Robot Learning.

Recent progress in robot learning has demonstrated how robots can acquire complex manipulation skills from perceptual inputs through trial and error, particularly with the use of deep neural networks. Despite these successes, the generalization and versatility of robots across environment conditions, tasks, and objects remains a major challenge. And, unfortunately, our existing algorithms and training set-ups are not prepared to tackle such challenges, which demand large and diverse sets of tasks and experiences. In this talk, I will discuss two central challenges that pertain to data scalability: first, acquiring large datasets of diverse and useful interactions with the world, and second, developing algorithms that can learn from such datasets. Then, I will describe multiple approaches that we might take to rethink our algorithms and data pipelines to serve these goals. This will include algorithms that allow a real robot to explore its environment in a targeted manner with minimal supervision, approaches that can perform robot reinforcement learning with videos of human trial-and-error experience, and visual model-based RL approaches that are not bottlenecked by their capacity to model everything about the world.

[ CMU RI ] Continue reading →

Posted in Human Robots

#437628 Video Friday: An In-Depth Look at Mesmer ...

Posted on November 22, 2020 by Android

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

AUVSI EXPONENTIAL 2020 – October 5-8, 2020 – [Online]
IROS 2020 – October 25-29, 2020 – [Online]
ROS World 2020 – November 12, 2020 – [Online]
CYBATHLON 2020 – November 13-14, 2020 – [Online]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today’s videos.

Bear Robotics, a robotics and artificial intelligence company, and SoftBank Robotics Group, a leading robotics manufacturer and solutions provider, have collaborated to bring a new robot named Servi to the food service and hospitality field.

[ Bear Robotics ]

A literal in-depth look at Engineered Arts’ Mesmer android.

[ Engineered Arts ]

Is your robot running ROS? Is it connected to the Internet? Are you actually in control of it right now? Are you sure?

I appreciate how the researchers admitted to finding two of their own robots as part of the scan, a Baxter and a drone.

[ Brown ]

Smile Robotics describes this as “(possibly) world’s first full-autonomous clear-up-the-table robot.”

We’re not qualified to make a judgement on the world firstness, but personally I hate clearing tables, so this robot has my vote.

Smile Robotics founder and CEO Takashi Ogura, along with chief engineer Mitsutaka Kabasawa and engineer Kazuya Kobayashi, are former Google roboticists. Ogura also worked at SCHAFT. Smile says its robot uses ROS and is controlled by a framework written mainly in Rust, adding: “We are hiring Rustacean Roboticists!”

[ Smile Robotics ]

We’re not entirely sure why, but Panasonic has released plans for an Internet of Things system for hamsters.

We devised a recipe for a “small animal healthcare device” that can measure the weight and activity of small animals, the temperature and humidity of the breeding environment, and manage their health. This healthcare device visualizes the health status and breeding environment of small animals and manages their health to promote early detection of diseases. While imagining the scene where a healthcare device is actually used for an important small animal that we treat with affection, we hope to help overcome the current difficult situation through manufacturing.

[ Panasonic ] via [ RobotStart ]

Researchers at Yale have developed a robotic fabric, a breakthrough that could lead to such innovations as adaptive clothing, self-deploying shelters, or lightweight shape-changing machinery.

The researchers focused on processing functional materials into fiber-form so they could be integrated into fabrics while retaining its advantageous properties. For example, they made variable stiffness fibers out of an epoxy embedded with particles of Field’s metal, an alloy that liquifies at relatively low temperatures. When cool, the particles are solid metal and make the material stiffer; when warm, the particles melt into liquid and make the material softer.

[ Yale ]

In collaboration with Armasuisse and SBB, RSL demonstrated the use of a teleoperated Menzi Muck M545 to clean up a rock slide in Central Switzerland. The machine can be operated from a teloperation platform with visual and motion feedback. The walking excavator features an active chassis that can adapt to uneven terrain.

[ ETHZ RSL ]

An international team of JKU researchers is continuing to develop their vision for robots made out of soft materials. A new article in the journal “Communications Materials” demonstrates just how these kinds of soft machines react using weak magnetic fields to move very quickly. A triangle-shaped robot can roll itself in air at high speed and walk forward when exposed to an alternating in-plane square wave magnetic field (3.5 mT, 1.5 Hz). The diameter of the robot is 18 mm with a thickness of 80 µm. A six-arm robot can grab, transport, and release non-magnetic objects such as a polyurethane foam cube controlled by a permanent magnet.

Okay but tell me more about that cute sheep.

[ JKU ]

Interbotix has this “research level robotic crawler,” which both looks mean and runs ROS, a dangerous combination.

And here’s how it all came together:

[ Interbotix ]

I guess if you call them “loitering missile systems” rather than “drones that blow things up” people are less likely to get upset?

[ AeroVironment ]

In this video, we show a planner for a master dual-arm robot to manipulate tethered tools with an assistant dual-arm robot’s help. The assistant robot provides assistance to the master robot by manipulating the tool cable and avoiding collisions. The provided assistance allows the master robot to perform tool placements on the robot workspace table to regrasp the tool, which would typically fail since the tool cable tension may change the tool positions. It also allows the master robot to perform tool handovers, which would normally cause entanglements or collisions with the cable and the environment without the assistance.

[ Harada Lab ]

This video shows a flexible and robust robotic system for autonomous drawing on 3D surfaces. The system takes 2D drawing strokes and a 3D target surface (mesh or point clouds) as input. It maps the 2D strokes onto the 3D surface and generates a robot motion to draw the mapped strokes using visual recognition, grasp pose reasoning, and motion planning.

[ Harada Lab ]

Weekly mobility test. This time the Warthog takes on a fallen tree. Will it cross it? The answer is in the video!

And the answer is: kinda?

[ NORLAB ]

One of the advantages of walking machines is their ability to apply forces in all directions and of various magnitudes to the environment. Many of the multi-legged robots are equipped with point contact feet as these simplify the design and control of the robot. The iStruct project focuses on the development of a foot that allows extensive contact with the environment.

[ DFKI ]

An urgent medical transport was simulated in NASA’s second Systems Integration and Operationalization (SIO) demonstration Sept. 28 with partner Bell Textron Inc. Bell used the remotely-piloted APT 70 to conduct a flight representing an urgent medical transport mission. It is envisioned in the future that an operational APT 70 could provide rapid medical transport for blood, organs, and perishable medical supplies (payload up to 70 pounds). The APT 70 is estimated to move three times as fast as ground transportation.

Always a little suspicious when the video just shows the drone flying, and sitting on the ground, but not that tricky transition between those two states.

[ NASA ]

A Lockheed Martin Robotics Seminar on “Socially Assistive Mobile Robots,” by Yi Guo from Stevens Institute of Technology.

The use of autonomous mobile robots in human environments is on the rise. Assistive robots have been seen in real-world environments, such as robot guides in airports, robot polices in public parks, and patrolling robots in supermarkets. In this talk, I will first present current research activities conducted in the Robotics and Automation Laboratory at Stevens. I’ll then focus on robot-assisted pedestrian regulation, where pedestrian flows are regulated and optimized through passive human-robot interaction.

[ UMD ]

This week’s CMU RI Seminar is by CMU’s Zachary Manchester, on “The World’s Tiniest Space Program.”

The aerospace industry has experienced a dramatic shift over the last decade: Flying a spacecraft has gone from something only national governments and large defense contractors could afford to something a small startup can accomplish on a shoestring budget. A virtuous cycle has developed where lower costs have led to more launches and the growth of new markets for space-based data. However, many barriers remain. This talk will focus on driving these trends to their ultimate limit by harnessing advances in electronics, planning, and control to build spacecraft that cost less than a new smartphone and can be deployed in large numbers.

[ CMU RI ] Continue reading →

Posted in Human Robots

#437603 Throwable Robot Car Always Lands on Four ...

Posted on November 21, 2020 by Android

Throwable or droppable robots seem like a great idea for a bunch of applications, including exploration and search and rescue. But such robots do come with some constraints—namely, if you’re going to throw or drop a robot, you should be prepared for that robot to not land the way you want it to land. While we’ve seen some creative approaches to this problem, or more straightforward self-righting devices, usually you’re in for significant trade-offs in complexity, mobility, and mass.

What would be ideal is a robot that can be relied upon to just always land the right way up. A robotic cat, of sorts. And while we’ve seen this with a tail, for wheeled vehicles, it turns out that a tail isn’t necessary: All it takes is some wheel spin.

The reason that AGRO (Agile Ground RObot), developed at the U.S. Military Academy at West Point, can do this is because each of its wheels is both independently driven and steerable. The wheels are essentially reaction wheels, which are a pretty common way to generate forces on all kinds of different robots, but typically you see such reaction wheels kludged onto these robots as sort of an afterthought—using the existing wheels of a wheeled robot is a more elegant way to do it.

Four steerable wheels with in-hub motors provide control in all three axes (yaw, pitch, and roll). You’ll notice that when the robot is tossed, the wheels all toe inwards (or outwards, I guess) by 45 degrees, positioning them orthogonal to the body of the robot. The front left and rear right wheels are spun together, as are the front right and rear left wheels. When one pair of wheels spins in the same direction, the body of the robot twists in the opposite way along an axis between those wheels, in a combination of pitch and roll. By combining different twisting torques from both pairs of wheels, pitch and roll along each axis can be adjusted independently. When the same pair of wheels spin in directions opposite to each other, the robot yaws, although yaw can also be derived by adjusting the ratio between pitch authority and roll authority. And lastly, if you want to sacrifice pitch control for more roll control (or vice versa) the wheel toe-in angle can be changed. Put all this together, and you get an enormous amount of mid-air control over your robot.

Image: Robotics Research Center/West Point

The AGRO robot features four steerable wheels with in-hub motors, which provide control in all three axes (yaw, pitch, and roll).

According to a paper that the West Point group will present at the 2020 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), the overall objective here is for the robot to reach a state of zero pitch or roll by the time the robot impacts with the ground, to distribute the impact as much as possible. AGRO doesn’t yet have a suspension to make falling actually safe, so in the short term, it lands on a foam pad, but the mid-air adjustments it’s currently able to make result in a 20 percent reduction of impact force and a 100 percent reduction in being sideways or upside-down.

The toss that you see in the video isn’t the most aggressive, but lead author Daniel J. Gonzalez tells us that AGRO can do much better, theoretically stabilizing from an initial condition of 22.5 degrees pitch and 22.5 degrees roll in a mere 250 milliseconds, with room for improvement beyond that through optimizing the angles of individual wheels in real time. The limiting factor is really the amount of time that AGRO has between the point at which it’s released and the point at which it hits the ground, since more time in the air gives the robot more time to change its orientation.

Given enough height, the current generation of AGRO can recover from any initial orientation as long as it’s spinning at 66 rpm or less. And the only reason this is a limitation at all is because of the maximum rotation speed of the in-wheel hub motors, which can be boosted by increasing the battery voltage, as Gonzalez and his colleagues, Mark C. Lesak, Andres H. Rodriguez, Joseph A. Cymerman, and Christopher M. Korpela from the Robotics Research Center at West Point, describe in the IROS paper, “Dynamics and Aerial Attitude Control for Rapid Emergency Deployment of the Agile Ground Robot AGRO.”

Image: Robotics Research Center/West Point

AGRO 2 will include a new hybrid wheel-leg and non-pneumatic tire design that will allow it to hop up stairs and curbs.

While these particular experiments focus on a robot that’s being thrown, the concept is potentially effective (and useful) on any wheeled robot that’s likely to find itself in mid-air. You can imagine it improving the performance of robots doing all sorts of stunts, from driving off ramps or ledges to being dropped out of aircraft. And as it turns out, being able to self-stabilize during an airdrop is an important skill that some Humvees could use to keep themselves from getting tangled in their own parachute lines and avoid mishaps.

Before they move on to Humvees, though, the researchers are working on the next version of AGRO named AGRO 2. AGRO 2 will include a new hybrid wheel-leg and non-pneumatic tire design that will allow it to hop up stairs and curbs, which sounds like a lot of fun to us. Continue reading →

Posted in Human Robots

#437564 How We Won the DARPA SubT Challenge: ...

Posted on November 18, 2020 by Android

This is a guest post. The views expressed here are those of the authors and do not necessarily represent positions of IEEE or its organizational units.​

“Do you smell smoke?” It was three days before the qualification deadline for the Virtual Tunnel Circuit of the DARPA Subterranean Challenge Virtual Track, and our team was barrelling through last-minute updates to our robot controllers in a small conference room at the Michigan Tech Research Institute (MTRI) offices in Ann Arbor, Mich. That’s when we noticed the smell. We’d assumed that one of the benefits of entering a virtual disaster competition was that we wouldn’t be exposed to any actual disasters, but equipment in the basement of the building MTRI shares had started to smoke. We evacuated. The fire department showed up. And as soon as we could, the team went back into the building, hunkered down, and tried to make up for the unexpected loss of several critical hours.

Team BARCS joins the SubT Virtual Track
The smoke incident happened more than a year after we first learned of the DARPA Subterranean Challenge. DARPA announced SubT early in 2018, and at that time, we were interested in building internal collaborations on multi-agent autonomy problems, and SubT seemed like the perfect opportunity. Though a few of us had backgrounds in robotics, the majority of our team was new to the field. We knew that submitting a proposal as a largely non-traditional robotics team from an organization not known for research in robotics was a risk. However, the Virtual Track gave us the opportunity to focus on autonomy and multi-agent teaming strategies, areas requiring skill in asynchronous computing and sensor data processing that are strengths of our Institute. The prevalence of open source code, small inexpensive platforms, and customizable sensors has provided the opportunity for experts in fields other than robotics to apply novel approaches to robotics problems. This is precisely what makes the Virtual Track of SubT appealing to us, and since starting SubT, autonomy has developed into a significant research thrust for our Institute. Plus, robots are fun!

After many hours of research, discussion, and collaboration, we submitted our proposal early in 2018. And several months later, we found out that we had won a contract and became a funded team (Team BARCS) in the SubT Virtual Track. Now we needed to actually make our strategy work for the first SubT Tunnel Circuit competition, taking place in August of 2019.

Building a team of virtual robots
A natural approach to robotics competitions like SubT is to start with the question of “what can X-type robot do” and then build a team and strategy around individual capabilities. A particular challenge for the SubT Virtual Track is that we can’t design our own systems; instead, we have to choose from a predefined set of simulated robots and sensors that DARPA provides, based on the real robots used by Systems Track teams. Our approach is to look at what a team of robots can do together, determining experimentally what the best team configuration is for each environment. By the final competition, ideally we will be demonstrating the value of combining platforms across multiple Systems Track teams into a single Virtual Track team. Each of the robot configurations in the competition has an associated cost, and team size is constrained by a total cost. This provides another impetus for limiting dependence on complex sensor packages, though our ranging preference is 3D lidar, which is the most expensive sensor!

Image: Michigan Tech Research Institute

The teams can rely on realistic physics and sensors but they start off with no maps of any kind, so the focus is on developing autonomous exploratory behavior, navigation methods, and object recognition for their simulated robots.

One of the frequent questions we receive about the Virtual Track is if it’s like a video game. While it may look similar on the surface, everything under the hood in a video game is designed to service the game narrative and play experience, not require novel research in AI and autonomy. The purpose of simulations, on the other hand, is to include full physics and sensor models (including noise and errors) to provide a testbed for prototyping and developing solutions to those real-world challenges. We are starting with realistic physics and sensors but no maps of any kind, so the focus is on developing autonomous exploratory behavior, navigation methods, and object recognition for our simulated robots.

Though the simulation is more like real life than a video game, it is not real life. Due to occasional software bugs, there are still non-physical events, like the robots falling through an invisible hole in the world or driving through a rock instead of over it or flipping head over heels when driving over a tiny lip between world tiles. These glitches, while sometimes frustrating, still allow the SubT Virtual platform to be realistic enough to support rapid prototyping of controller modules that will transition straightforwardly onto hardware, closing the loop between simulation and real-world robots.

Full autonomy for DARPA-hard scenarios
The Virtual Track requirement that the robotic agents be fully autonomous, rather than have a human supervisor, is a significant distinction between the Systems and Virtual Tracks of SubT. Our solutions must be hardened against software faults caused by things like missing and bad data since our robots can’t turn to us for help. In order for a team of robots to complete this objective reliably with no human-in-the-loop, all of the internal systems, from perception to navigation to control to actuation to communications, must be able to autonomously identify and manage faults and failures anywhere in the control chain.

The communications limitations in subterranean environments (both real and virtual) mean that we need to keep the amount of information shared between robots low, while making the usability of that information for joint decision-making high. This goal has guided much of our design for autonomous navigation and joint search strategy for our team. For example, instead of sharing the full SLAM map of the environment, our agents only share a simplified graphical representation of the space, along with data about frontiers it has not yet explored, and are able to merge its information with the graphs generated by other agents. The merged graph can then be used for planning and navigation without having full knowledge of the detailed 3D map.

The Virtual Track requires that the robotic agents be fully autonomous. With no human-in-the-loop, all of the internal systems, from perception to navigation to control to actuation to communications, must be able to identify and manage faults and failures anywhere in the control chain.

Since the objective of the SubT program is to advance the state-of-the-art in rapid autonomous exploration and mapping of subterranean environments by robots, our first software design choices focused on the mapping task. The SubT virtual environments are sufficiently rich as to provide interesting problems in building so-called costmaps that accurately separate obstructions that are traversable (like ramps) from legitimately impassible obstructions. An extra complication we discovered in the first course, which took place in mining tunnels, was that the angle of the lowest beam of the lidar was parallel to the down ramps in the tunnel environment, so they could not “see” the ground (or sometimes even obstructions on the ramp) until they got close enough to the lip of the ramp to receive lidar reflections off the bottom of the ramp. In this case, we had to not only change the costmap to convince the robot that there was safe ground to reach over the lip of the ramp, but also had to change the path planner to get the robot to proceed with caution onto the top of the ramp in case there were previously unseen obstructions on the ramp.

In addition to navigation in the costmaps, the robot must be able to generate its own goals to navigate to. This is what produces exploratory behavior when there is no map to start with. SLAM is used to generate a detailed map of the environment explored by a single robot—the space it has probed with its sensors. From the sensor data, we are able to extract information about the interior space of the environment while looking for holes in the data, to determine things like whether the current tunnel continues or ends, or how many tunnels meet at an intersection. Once we have some understanding of the interior space, we can place navigation goals in that space. These goals naturally update as the robot traverses the tunnel, allowing the entire space to be explored.

Sending our robots into the virtual unknown
The solutions for the Virtual Track competitions are tested by DARPA in multiple sequestered runs across many environments for each Circuit in the month prior to the Systems Track competition. We must wait until the joint award ceremony at the conclusion of the Systems Track to find out the results, and we are completely in the dark about placings before the awards are announced. It’s nerve-wracking! The challenges of the worlds used in the Circuit events are also hand-designed, so features of the worlds we use for development could be combined in ways we have not anticipated—it’s always interesting to see what features were prioritized after the event. We test everything in our controllers well enough to feel confident that we at least are submitting something reasonably stable and broadly capable, and once the solution is in, we can’t really do anything other than “let go” and get back to work on the next phase of development. Maybe it’s somewhat like sending your kid to college: “we did our best to prepare you for this world, little bots. Go do good.”

Image: Michigan Tech Research Institute

The first SubT competition was the Tunnel Circuit, featuring a labyrinthine environment that simulated human-engineered tunnels, including hazards such as vertical shafts and rubble.

The first competition was the Tunnel Circuit, in October 2019. This environment models human-engineered tunnels. Two substantial challenges in this environment were vertical shafts and rubble. Our team accrued 21 points over 15 competition runs in five separate tunnel environments for a second place finish, behind Team Coordinated Robotics.

The next phase of the SubT virtual competition was the Urban Circuit. Much of the difference between our Tunnel and Urban Circuit results came down to thorough testing to identify failure modes and implementations of checks and data filtering for fault tolerance. For example, in the SLAM nodes run by a single robot, the coordinates of the most recent sensor data are changed multiple times during processing and integration into the current global 3D map of the “visited” environment stored by that robot. If there is lag in IMU or clock data, the observation may be temporarily registered at a default location that is very far from the actual position. Since most of our decision processes for exploration are downstream from SLAM, this can cause faulty or impossible goals to be generated, and the robots then spend inordinate amounts of time trying to drive through walls. We updated our method to add a check to see if the new map position has jumped a far distance from the prior map position, and if so, we threw that data out.

Image: Michigan Tech Research Institute

In open spaces like the rooms in the Urban circuit, we adjusted our approach to exploration through graph generation to allow the robots to accurately identify viable routes while helping to prevent forays off platform edges.

Our approach to exploration through graph generation based on identification of interior spaces allowed us to thoroughly explore the centers of rooms, although we did have to make some changes from the Tunnel circuit to achieve that. In the Tunnel circuit, we used a simplified graph of the environment based on landmarks like intersections. The advantage of this approach is that it is straightforward for two robots to compare how the graphs of the space they explored individually overlap. In open spaces like the rooms in the Urban circuit, we chose to instead use a more complex, less directly comparable graph structure based on the individual robot’s trajectory. This allowed the robots to accurately identify viable routes between features like subway station platforms and subway tracks, as well as to build up the navigation space for room interiors, while helping to prevent forays off the platform edges. Frontier information is also integrated into the graph, providing a uniform data structure for both goal selection and route planning.

The results are in!
The award ceremony for the Urban Circuit was held concurrently with the Systems Track competition awards this past February in Washington State. We sent a team representative to participate in the Technical Interchange Meeting and present the approach for our team, and the rest of us followed along from our office space on the DARPAtv live stream. While we were confident in our solution, we had also been tracking the online leaderboard and knew our competitors were going to be submitting strong solutions. Since the competition environments are hand-designed, there are always novel challenges that could be presented in these environments as well. We knew we would put up a good fight, but it was very exciting to see BARCS appear in first place!

Any time we implement a new module in our control system, there is a lot of parameter tuning that has to happen to produce reliably good autonomous behavior. In the Urban Circuit, we did not sufficiently test some parameter values in our exploration modules. The effect of this was that the robots only chose to go down small hallways after they explored everything else in their environment, which meant very often they ran out of time and missed a lot of small rooms. This may be the biggest source of lost points for us in the Urban Circuit. One of our major plans going forward from the Urban Circuit is to integrate more sophisticated node selection methods, which can help our robots more intelligently prioritize which frontier nodes to visit. By going through all three Circuit challenges, we will learn how to appropriately add weights to the frontiers based on features of the individual environments. For the Final Challenge, when all three Circuit environments will be combined into large systems, we plan to implement adaptive controllers that will identify their environments and use the appropriate optimized parameters for that environment. In this way, we expect our agents to be able to (for example) prioritize hallways and other small spaces in Urban environments, and perhaps prioritize large openings over small in the Cave environments, if the small openings end up being treacherous overall.

Next for our team: Cave Circuit
Coming up next for Team BARCS is the Virtual Cave Circuit. We are in the middle of testing our hypothesis that our controller will transition from UGVs to UAVs and developing strategies for refining our solution to handle Cave Circuit environmental hazards. The UAVs have a shorter battery life than the UGVs, so executing a joint exploration strategy will also be a high priority for this event, as will completing our work on graph sharing and merging, which will give our robot teams more sophisticated options for navigation and teamwork. We’re reaching a threshold in development where we can start increasing the “smarts” of the robots, which we anticipate will be critical for the final competition, where all of the challenges of SubT will be combined to push the limits of innovation. The Cave Circuit will also have new environmental challenges to tackle: dynamic features such as rock falls have been added, which will block previously accessible passages in the cave environment. We think our controllers are well-poised to handle this new challenge, and we’re eager to find out if that’s the case.

As of now, the biggest worries for us are time and team composition. The Cave Circuit deadline has been postponed to October 15 due to COVID-19 delays, with the award ceremony in mid-November, but there have also been several very compelling additions to the testbed that we would like to experiment with before submission, including droppable networking ‘breadcrumbs’ and new simulated platforms. There are design trade-offs when balancing general versus specialist approaches to the controllers for these robots—since we are adding UAVs to our team for the first time, there are new decisions that will have to be made. For example, the UAVs can ascend into vertical spaces, but only have a battery life of 20 minutes. The UGVs by contrast have 90 minute battery life. One of our strategies is to do an early return to base with one or more agents to buy down risk on making any artifact reports at all for the run, hedging against our other robots not making it back in time, a lesson learned from the Tunnel Circuit. Should a UAV take on this role, or is it better to have them explore deeper into the environment and instead report their artifacts to a UGV or network node, which comes with its own risks? Testing and experimentation to determine the best options takes time, which is always a worry when preparing for a competition! We also anticipate new competitors and stiffer competition all around.

Image: Michigan Tech Research Institute

Team BARCS has now a year to prepare for the final DARPA SubT Challenge event, expected to take place in late 2021.

Going forward from the Cave Circuit, we will have a year to prepare for the final DARPA SubT Challenge event, expected to take place in late 2021. What we are most excited about is increasing the level of intelligence of the agents in their teamwork and joint exploration of the environment. Since we will have (hopefully) built up robust approaches to handling each of the specific types of environments in the Tunnel, Urban, and Cave circuits, we will be aiming to push the limits on collaboration and efficiency among the agents in our team. We view this as a central research contribution of the Virtual Track to the Subterranean Challenge because intelligent, adaptive, multi-robot collaboration is an upcoming stage of development for integration of robots into our lives.

The Subterranean Challenge Virtual Track gives us a bridge for transitioning our more abstract research ideas and algorithms relevant to this degree of autonomy and collaboration onto physical systems, and exploring the tangible outcomes of implementing our work in the real world. And the next time there’s an incident in the basement of our building, the robots (and humans) of Team BARCS will be ready to respond.

Richard Chase, Ph.D., P.E., is a research scientist at Michigan Tech Research Institute (MTRI) and has 20 years of experience developing robotics and cyber physical systems in areas from remote sensing to autonomous vehicles. At MTRI, he works on a variety of topics such as swarm autonomy, human-swarm teaming, and autonomous vehicles. His research interests are the intersection of design, robotics, and embedded systems.

Sarah Kitchen is a Ph.D. mathematician working as a research scientist and an AI/Robotics focus area leader at MTRI. Her research interests include intelligent autonomous agents and multi-agent collaborative teams, as well as applications of autonomous robots to sensing systems.

This material is based upon work supported by the Defense Advanced Research Projects Agency (DARPA) under Contract No. HR001118C0124 and is released under Distribution Statement (Approved for Public Release, Distribution Unlimited). Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of DARPA. Continue reading →

Posted in Human Robots