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#435628 Soft Exosuit Makes Walking and Running ...
Researchers at Harvard’s Wyss Institute have been testing a flexible, lightweight exosuit that can improve your metabolic efficiency by 4 to 10 percent while walking and running. This is very important because, according to a press release from Harvard, the suit can help you be faster and more efficient, whether you’re “walking at a leisurely pace,” or “running for your life.” Great!
Making humans better at running for their lives is something that we don’t put nearly enough research effort into, I think. The problem may not come up very often, but when it does, it’s super important (because, bears). So, sign me up for anything that we can do to make our desperate flights faster or more efficient—especially if it’s a lightweight, wearable exosuit that’s soft, flexible, and comfortable to wear.
This is the same sort of exosuit that was part of a DARPA program that we wrote about a few years ago, which was designed to make it easier for soldiers to carry heavy loads for long distances.
Photos: Wyss Institute at Harvard University
The system uses two waist-mounted electrical motors connected with cables to thigh straps that run down around your butt. The motors pull on the cables at the same time that your muscles actuate, helping them out and reducing the amount of work that your muscles put in without decreasing the amount of force they exert on your legs. The entire suit (batteries included) weighs 5 kilograms (11 pounds).
In order for the cables to actuate at the right time, the suit tracks your gait with two inertial measurement units (IMUs) on the thighs and one on the waist, and then adjusts its actuation profile accordingly. It works well, too, with measurable increases in performance:
We show that a portable exosuit that assists hip extension can reduce the metabolic rate of treadmill walking at 1.5 meters per second by 9.3 percent and that of running at 2.5 meters per second by 4.0 percent compared with locomotion without the exosuit. These reduction magnitudes are comparable to the effects of taking off 7.4 and 5.7 kilograms during walking and running, respectively, and are in a range that has shown meaningful athletic performance changes.
By increasing your efficiency, you can think of the suit as being able to make you walk or run faster, or farther, or carry a heavier load, all while spending the same amount of energy (or less), which could be just enough to outrun the bear that’s chasing you. Plus, it doesn’t appear to be uncomfortable to wear, and doesn’t require the user to do anything differently, which means that (unlike most robotics things) it’s maybe actually somewhat practical for real-world use—whether you’re indoors or outdoors, or walking or running, or being chased by a bear or not.
Sadly, I have no idea when you might be able to buy one of these things. But the researchers are looking for ways to make the suit even easier to use, while also reducing the weight and making the efficiency increase more pronounced. Harvard’s Conor Walsh says they’re “excited to continue to apply it to a range of applications, including assisting those with gait impairments, industry workers at risk of injury performing physically strenuous tasks, or recreational weekend warriors.” As a weekend warrior who is not entirely sure whether he can outrun a bear, I’m excited for this.
Reducing the metabolic rate of walking and running with a versatile, portable exosuit, by Jinsoo Kim, Giuk Lee, Roman Heimgartner, Dheepak Arumukhom Revi, Nikos Karavas, Danielle Nathanson, Ignacio Galiana, Asa Eckert-Erdheim, Patrick Murphy, David Perry, Nicolas Menard, Dabin Kim Choe, Philippe Malcolm, and Conor J. Walsh from the Wyss Institute for Biologically Inspired Engineering at Harvard University, appears in the current issue of Science. Continue reading
#433884 Designer Babies, and Their Babies: How ...
As if stand-alone technologies weren’t advancing fast enough, we’re in age where we must study the intersection points of these technologies. How is what’s happening in robotics influenced by what’s happening in 3D printing? What could be made possible by applying the latest advances in quantum computing to nanotechnology?
Along these lines, one crucial tech intersection is that of artificial intelligence and genomics. Each field is seeing constant progress, but Jamie Metzl believes it’s their convergence that will really push us into uncharted territory, beyond even what we’ve imagined in science fiction. “There’s going to be this push and pull, this competition between the reality of our biology with its built-in limitations and the scope of our aspirations,” he said.
Metzl is a senior fellow at the Atlantic Council and author of the upcoming book Hacking Darwin: Genetic Engineering and the Future of Humanity. At Singularity University’s Exponential Medicine conference last week, he shared his insights on genomics and AI, and where their convergence could take us.
Life As We Know It
Metzl explained how genomics as a field evolved slowly—and then quickly. In 1953, James Watson and Francis Crick identified the double helix structure of DNA, and realized that the order of the base pairs held a treasure trove of genetic information. There was such a thing as a book of life, and we’d found it.
In 2003, when the Human Genome Project was completed (after 13 years and $2.7 billion), we learned the order of the genome’s 3 billion base pairs, and the location of specific genes on our chromosomes. Not only did a book of life exist, we figured out how to read it.
Jamie Metzl at Exponential Medicine
Fifteen years after that, it’s 2018 and precision gene editing in plants, animals, and humans is changing everything, and quickly pushing us into an entirely new frontier. Forget reading the book of life—we’re now learning how to write it.
“Readable, writable, and hackable, what’s clear is that human beings are recognizing that we are another form of information technology, and just like our IT has entered this exponential curve of discovery, we will have that with ourselves,” Metzl said. “And it’s intersecting with the AI revolution.”
Learning About Life Meets Machine Learning
In 2016, DeepMind’s AlphaGo program outsmarted the world’s top Go player. In 2017 AlphaGo Zero was created: unlike AlphaGo, AlphaGo Zero wasn’t trained using previous human games of Go, but was simply given the rules of Go—and in four days it defeated the AlphaGo program.
Our own biology is, of course, vastly more complex than the game of Go, and that, Metzl said, is our starting point. “The system of our own biology that we are trying to understand is massively, but very importantly not infinitely, complex,” he added.
Getting a standardized set of rules for our biology—and, eventually, maybe even outsmarting our biology—will require genomic data. Lots of it.
Multiple countries already starting to produce this data. The UK’s National Health Service recently announced a plan to sequence the genomes of five million Britons over the next five years. In the US the All of Us Research Program will sequence a million Americans. China is the most aggressive in sequencing its population, with a goal of sequencing half of all newborns by 2020.
“We’re going to get these massive pools of sequenced genomic data,” Metzl said. “The real gold will come from comparing people’s sequenced genomes to their electronic health records, and ultimately their life records.” Getting people comfortable with allowing open access to their data will be another matter; Metzl mentioned that Luna DNA and others have strategies to help people get comfortable with giving consent to their private information. But this is where China’s lack of privacy protection could end up being a significant advantage.
To compare genotypes and phenotypes at scale—first millions, then hundreds of millions, then eventually billions, Metzl said—we’re going to need AI and big data analytic tools, and algorithms far beyond what we have now. These tools will let us move from precision medicine to predictive medicine, knowing precisely when and where different diseases are going to occur and shutting them down before they start.
But, Metzl said, “As we unlock the genetics of ourselves, it’s not going to be about just healthcare. It’s ultimately going to be about who and what we are as humans. It’s going to be about identity.”
Designer Babies, and Their Babies
In Metzl’s mind, the most serious application of our genomic knowledge will be in embryo selection.
Currently, in-vitro fertilization (IVF) procedures can extract around 15 eggs, fertilize them, then do pre-implantation genetic testing; right now what’s knowable is single-gene mutation diseases and simple traits like hair color and eye color. As we get to the millions and then billions of people with sequences, we’ll have information about how these genetics work, and we’re going to be able to make much more informed choices,” Metzl said.
Imagine going to a fertility clinic in 2023. You give a skin graft or a blood sample, and using in-vitro gametogenesis (IVG)—infertility be damned—your skin or blood cells are induced to become eggs or sperm, which are then combined to create embryos. The dozens or hundreds of embryos created from artificial gametes each have a few cells extracted from them, and these cells are sequenced. The sequences will tell you the likelihood of specific traits and disease states were that embryo to be implanted and taken to full term. “With really anything that has a genetic foundation, we’ll be able to predict with increasing levels of accuracy how that potential child will be realized as a human being,” Metzl said.
This, he added, could lead to some wild and frightening possibilities: if you have 1,000 eggs and you pick one based on its optimal genetic sequence, you could then mate your embryo with somebody else who has done the same thing in a different genetic line. “Your five-day-old embryo and their five-day-old embryo could have a child using the same IVG process,” Metzl said. “Then that child could have a child with another five-day-old embryo from another genetic line, and you could go on and on down the line.”
Sounds insane, right? But wait, there’s more: as Jason Pontin reported earlier this year in Wired, “Gene-editing technologies such as Crispr-Cas9 would make it relatively easy to repair, add, or remove genes during the IVG process, eliminating diseases or conferring advantages that would ripple through a child’s genome. This all may sound like science fiction, but to those following the research, the combination of IVG and gene editing appears highly likely, if not inevitable.”
From Crazy to Commonplace?
It’s a slippery slope from gene editing and embryo-mating to a dystopian race to build the most perfect humans possible. If somebody’s investing so much time and energy in selecting their embryo, Metzl asked, how will they think about the mating choices of their children? IVG could quickly leave the realm of healthcare and enter that of evolution.
“We all need to be part of an inclusive, integrated, global dialogue on the future of our species,” Metzl said. “Healthcare professionals are essential nodes in this.” Not least among this dialogue should be the question of access to tech like IVG; are there steps we can take to keep it from becoming a tool for a wealthy minority, and thereby perpetuating inequality and further polarizing societies?
As Pontin points out, at its inception 40 years ago IVF also sparked fear, confusion, and resistance—and now it’s as normal and common as could be, with millions of healthy babies conceived using the technology.
The disruption that genomics, AI, and IVG will bring to reproduction could follow a similar story cycle—if we’re smart about it. As Metzl put it, “This must be regulated, because it is life.”
Image Credit: hywards / Shutterstock.com Continue reading