Tag Archives: platform

#435575 How an AI Startup Designed a Drug ...

Posted on September 9, 2019 by Android

Discovering a new drug can take decades, billions of dollars, and untold man hours from some of the smartest people on the planet. Now a startup says it’s taken a significant step towards speeding the process up using AI.

The typical drug discovery process involves carrying out physical tests on enormous libraries of molecules, and even with the help of robotics it’s an arduous process. The idea of sidestepping this by using computers to virtually screen for promising candidates has been around for decades. But progress has been underwhelming, and it’s still not a major part of commercial pipelines.

Recent advances in deep learning, however, have reignited hopes for the field, and major pharma companies have started tying up with AI-powered drug discovery startups. And now Insilico Medicine has used AI to design a molecule that effectively targets a protein involved in fibrosis—the formation of excess fibrous tissue—in mice in just 46 days.

The platform the company has developed combines two of the hottest sub-fields of AI: the generative adversarial networks, or GANs, which power deepfakes, and reinforcement learning, which is at the heart of the most impressive game-playing AI advances of recent years.

In a paper in Nature Biotechnology, the company’s researchers describe how they trained their model on all the molecules already known to target this protein as well as many other active molecules from various datasets. The model was then used to generate 30,000 candidate molecules.

Unlike most previous efforts, they went a step further and selected the most promising molecules for testing in the lab. The 30,000 candidates were whittled down to just 6 using more conventional drug discovery approaches and were then synthesized in the lab. They were put through increasingly stringent tests, but the leading candidate was found to be effective at targeting the desired protein and behaved as one would hope a drug would.

The authors are clear that the results are just a proof-of-concept, which company CEO Alex Zhavoronkov told Wired stemmed from a challenge set by a pharma partner to design a drug as quickly as possible. But they say they were able to carry out the process faster than traditional methods for a fraction of the cost.

There are some caveats. For a start, the protein being targeted is already very well known and multiple effective drugs exist for it. That gave the company a wealth of data to train their model on, something that isn’t the case for many of the diseases where we urgently need new drugs.

The company’s platform also only targets the very initial stages of the drug discovery process. The authors concede in their paper that the molecules would still take considerable optimization in the lab before they’d be true contenders for clinical trials.

“And that is where you will start to begin to commence to spend the vast piles of money that you will eventually go through in trying to get a drug to market,” writes Derek Lowe in his blog In The Pipeline. The part of the discovery process that the platform tackles represents a tiny fraction of the total cost of drug development, he says.

Nonetheless, the research is a definite advance for virtual screening technology and an important marker of the potential of AI for designing new medicines. Zhavoronkov also told Wired that this research was done more than a year ago, and they’ve since adapted the platform to go after harder drug targets with less data.

And with big pharma companies desperate to slash their ballooning development costs and find treatments for a host of intractable diseases, they can use all the help they can get.

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Posted in Human Robots

#435528 The Time for AI Is Now. Here’s Why

Posted on August 21, 2019 by Android

You hear a lot these days about the sheer transformative power of AI.

There’s pure intelligence: DeepMind’s algorithms readily beat humans at Go and StarCraft, and DeepStack triumphs over humans at no-limit hold’em poker. Often, these silicon brains generate gameplay strategies that don’t resemble anything from a human mind.

There’s astonishing speed: algorithms routinely surpass radiologists in diagnosing breast cancer, eye disease, and other ailments visible from medical imaging, essentially collapsing decades of expert training down to a few months.

Although AI’s silent touch is mainly felt today in the technological, financial, and health sectors, its impact across industries is rapidly spreading. At the Singularity University Global Summit in San Francisco this week Neil Jacobstein, Chair of AI and Robotics, painted a picture of a better AI-powered future for humanity that is already here.

Thanks to cloud-based cognitive platforms, sophisticated AI tools like deep learning are no longer relegated to academic labs. For startups looking to tackle humanity’s grand challenges, the tools to efficiently integrate AI into their missions are readily available. The progress of AI is massively accelerating—to the point you need help from AI to track its progress, joked Jacobstein.

Now is the time to consider how AI can impact your industry, and in the process, begin to envision a beneficial relationship with our machine coworkers. As Jacobstein stressed in his talk, the future of a brain-machine mindmeld is a collaborative intelligence that augments our own. “AI is reinventing the way we invent,” he said.

AI’s Rapid Revolution
Machine learning and other AI-based methods may seem academic and abstruse. But Jacobstein pointed out that there are already plenty of real-world AI application frameworks.

Their secret? Rather than coding from scratch, smaller companies—with big visions—are tapping into cloud-based solutions such as Google’s TensorFlow, Microsoft’s Azure, or Amazon’s AWS to kick off their AI journey. These platforms act as all-in-one solutions that not only clean and organize data, but also contain built-in security and drag-and-drop coding that allow anyone to experiment with complicated machine learning algorithms.

Google Cloud’s Anthos, for example, lets anyone migrate data from other servers—IBM Watson or AWS, for example—so users can leverage different computing platforms and algorithms to transform data into insights and solutions.

Rather than coding from scratch, it’s already possible to hop onto a platform and play around with it, said Jacobstein. That’s key: this democratization of AI is how anyone can begin exploring solutions to problems we didn’t even know we had, or those long thought improbable.

The acceleration is only continuing. Much of AI’s mind-bending pace is thanks to a massive infusion of funding. Microsoft recently injected $1 billion into OpenAI, the Elon Musk venture that engineers socially responsible artificial general intelligence (AGI).

The other revolution is in hardware, and Google, IBM, and NVIDIA—among others—are racing to manufacture computing chips tailored to machine learning.

Democratizing AI is like the birth of the printing press. Mechanical printing allowed anyone to become an author; today, an iPhone lets anyone film a movie masterpiece.

However, this diffusion of AI into the fabric of our lives means tech explorers need to bring skepticism to their AI solutions, giving them a dose of empathy, nuance, and humanity.

A Path Towards Ethical AI
The democratization of AI is a double-edged sword: as more people wield the technology’s power in real-world applications, problems embedded in deep learning threaten to disrupt those very judgment calls.

Much of the press on the dangers of AI focuses on superintelligence—AI that’s more adept at learning than humans—taking over the world, said Jacobstein. But the near-term threat, and far more insidious, is in humans misusing the technology.

Deepfakes, for example, allow AI rookies to paste one person’s head on a different body or put words into a person’s mouth. As the panel said, it pays to think of AI as a cybersecurity problem, one with currently shaky accountability and complexity, and one that fails at diversity and bias.

Take bias. Thanks to progress in natural language processing, Google Translate works nearly perfectly today, so much so that many consider the translation problem solved. Not true, the panel said. One famous example is how the algorithm translates gender-neutral terms like “doctor” into “he” and “nurse” into “she.”

These biases reflect our own, and it’s not just a data problem. To truly engineer objective AI systems, ones stripped of our society’s biases, we need to ask who is developing these systems, and consult those who will be impacted by the products. In addition to gender, racial bias is also rampant. For example, one recent report found that a supposedly objective crime-predicting system was trained on falsified data, resulting in outputs that further perpetuate corrupt police practices. Another study from Google just this month found that their hate speech detector more often labeled innocuous tweets from African-Americans as “obscene” compared to tweets from people of other ethnicities.

We often think of building AI as purely an engineering job, the panelists agreed. But similar to gene drives, germ-line genome editing, and other transformative—but dangerous—tools, AI needs to grow under the consultation of policymakers and other stakeholders. It pays to start young: educating newer generations on AI biases will mold malleable minds early, alerting them to the problem of bias and potentially mitigating risks.

As panelist Tess Posner from AI4ALL said, AI is rocket fuel for ambition. If young minds set out using the tools of AI to tackle their chosen problems, while fully aware of its inherent weaknesses, we can begin to build an AI-embedded future that is widely accessible and inclusive.

The bottom line: people who will be impacted by AI need to be in the room at the conception of an AI solution. People will be displaced by the new technology, and ethical AI has to consider how to mitigate human suffering during the transition. Just because AI looks like “magic fairy dust doesn’t mean that you’re home free,” the panelists said. You, the sentient human, bear the burden of being responsible for how you decide to approach the technology.

The time for AI is now. Let’s make it ethical.

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Posted in Human Robots

#435224 Can AI Save the Internet from Fake News?

Posted on June 30, 2019 by Android

There’s an old proverb that says “seeing is believing.” But in the age of artificial intelligence, it’s becoming increasingly difficult to take anything at face value—literally.

The rise of so-called “deepfakes,” in which different types of AI-based techniques are used to manipulate video content, has reached the point where Congress held its first hearing last month on the potential abuses of the technology. The congressional investigation coincided with the release of a doctored video of Facebook CEO Mark Zuckerberg delivering what appeared to be a sinister speech.

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Scientists are scrambling for solutions on how to combat deepfakes, while at the same time others are continuing to refine the techniques for less nefarious purposes, such as automating video content for the film industry.

At one end of the spectrum, for example, researchers at New York University’s Tandon School of Engineering have proposed implanting a type of digital watermark using a neural network that can spot manipulated photos and videos.

The idea is to embed the system directly into a digital camera. Many smartphone cameras and other digital devices already use AI to boost image quality and make other corrections. The authors of the study out of NYU say their prototype platform increased the chances of detecting manipulation from about 45 percent to more than 90 percent without sacrificing image quality.

On the other hand, researchers at Carnegie Mellon University recently hit on a technique for automatically and rapidly converting large amounts of video content from one source into the style of another. In one example, the scientists transferred the facial expressions of comedian John Oliver onto the bespectacled face of late night show host Stephen Colbert.

The CMU team says the method could be a boon to the movie industry, such as by converting black and white films to color, though it also conceded that the technology could be used to develop deepfakes.

Words Matter with Fake News
While the current spotlight is on how to combat video and image manipulation, a prolonged trench warfare on fake news is being fought by academia, nonprofits, and the tech industry.

This isn’t the fake news that some have come to use as a knee-jerk reaction to fact-based information that might be less than flattering to the subject of the report. Rather, fake news is deliberately-created misinformation that is spread via the internet.

In a recent Pew Research Center poll, Americans said fake news is a bigger problem than violent crime, racism, and terrorism. Fortunately, many of the linguistic tools that have been applied to determine when people are being deliberately deceitful can be baked into algorithms for spotting fake news.

That’s the approach taken by a team at the University of Michigan (U-M) to develop an algorithm that was better than humans at identifying fake news—76 percent versus 70 percent—by focusing on linguistic cues like grammatical structure, word choice, and punctuation.

For example, fake news tends to be filled with hyperbole and exaggeration, using terms like “overwhelming” or “extraordinary.”

“I think that’s a way to make up for the fact that the news is not quite true, so trying to compensate with the language that’s being used,” Rada Mihalcea, a computer science and engineering professor at U-M, told Singularity Hub.

The paper “Automatic Detection of Fake News” was based on the team’s previous studies on how people lie in general, without necessarily having the intention of spreading fake news, she said.

“Deception is a complicated and complex phenomenon that requires brain power,” Mihalcea noted. “That often results in simpler language, where you have shorter sentences or shorter documents.”

AI Versus AI
While most fake news is still churned out by humans with identifiable patterns of lying, according to Mihalcea, other researchers are already anticipating how to detect misinformation manufactured by machines.

A group led by Yejin Choi, with the Allen Institute of Artificial Intelligence and the University of Washington in Seattle, is one such team. The researchers recently introduced the world to Grover, an AI platform that is particularly good at catching autonomously-generated fake news because it’s equally good at creating it.

“This is due to a finding that is perhaps counterintuitive: strong generators for neural fake news are themselves strong detectors of it,” wrote Rowan Zellers, a PhD student and team member, in a Medium blog post. “A generator of fake news will be most familiar with its own peculiarities, such as using overly common or predictable words, as well as the peculiarities of similar generators.”

The team found that the best current discriminators can classify neural fake news from real, human-created text with 73 percent accuracy. Grover clocks in with 92 percent accuracy based on a training set of 5,000 neural network-generated fake news samples. Zellers wrote that Grover got better at scale, identifying 97.5 percent of made-up machine mumbo jumbo when trained on 80,000 articles.

It performed almost as well against fake news created by a powerful new text-generation system called GPT-2 built by OpenAI, a nonprofit research lab founded by Elon Musk, classifying 96.1 percent of the machine-written articles.

OpenAI had so feared that the platform could be abused that it has only released limited versions of the software. The public can play with a scaled-down version posted by a machine learning engineer named Adam King, where the user types in a short prompt and GPT-2 bangs out a short story or poem based on the snippet of text.

No Silver AI Bullet
While real progress is being made against fake news, the challenges of using AI to detect and correct misinformation are abundant, according to Hugo Williams, outreach manager for Logically, a UK-based startup that is developing different detectors using elements of deep learning and natural language processing, among others. He explained that the Logically models analyze information based on a three-pronged approach.

Publisher metadata: Is the article from a known, reliable, and trustworthy publisher with a history of credible journalism?
Network behavior: Is the article proliferating through social platforms and networks in ways typically associated with misinformation?
Content: The AI scans articles for hundreds of known indicators typically found in misinformation.

“There is no single algorithm which is capable of doing this,” Williams wrote in an email to Singularity Hub. “Even when you have a collection of different algorithms which—when combined—can give you relatively decent indications of what is unreliable or outright false, there will always need to be a human layer in the pipeline.”

The company released a consumer app in India back in February just before that country’s election cycle that was a “great testing ground” to refine its technology for the next app release, which is scheduled in the UK later this year. Users can submit articles for further scrutiny by a real person.

“We see our technology not as replacing traditional verification work, but as a method of simplifying and streamlining a very manual process,” Williams said. “In doing so, we’re able to publish more fact checks at a far quicker pace than other organizations.”

“With heightened analysis and the addition of more contextual information around the stories that our users are reading, we are not telling our users what they should or should not believe, but encouraging critical thinking based upon reliable, credible, and verified content,” he added.

AI may never be able to detect fake news entirely on its own, but it can help us be smarter about what we read on the internet.

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Posted in Human Robots

#435199 The Rise of AI Art—and What It Means ...

Posted on June 18, 2019 by Android

Artificially intelligent systems are slowly taking over tasks previously done by humans, and many processes involving repetitive, simple movements have already been fully automated. In the meantime, humans continue to be superior when it comes to abstract and creative tasks.

However, it seems like even when it comes to creativity, we’re now being challenged by our own creations.

In the last few years, we’ve seen the emergence of hundreds of “AI artists.” These complex algorithms are creating unique (and sometimes eerie) works of art. They’re generating stunning visuals, profound poetry, transcendent music, and even realistic movie scripts. The works of these AI artists are raising questions about the nature of art and the role of human creativity in future societies.

Here are a few works of art created by non-human entities.

Unsecured Futures
by Ai.Da

Ai-Da Robot with Painting. Image Credit: Ai-Da portraits by Nicky Johnston. Published with permission from Midas Public Relations.
Earlier this month we saw the announcement of Ai.Da, considered the first ultra-realistic drawing robot artist. Her mechanical abilities, combined with AI-based algorithms, allow her to draw, paint, and even sculpt. She is able to draw people using her artificial eye and a pencil in her hand. Ai.Da’s artwork and first solo exhibition, Unsecured Futures, will be showcased at Oxford University in July.

Ai-Da Cartesian Painting. Image Credit: Ai-Da Artworks. Published with permission from Midas Public Relations.
Obviously Ai.Da has no true consciousness, thoughts, or feelings. Despite that, the (human) organizers of the exhibition believe that Ai.Da serves as a basis for crucial conversations about the ethics of emerging technologies. The exhibition will serve as a stimulant for engaging with critical questions about what kind of future we ought to create via such technologies.

The exhibition’s creators wrote, “Humans are confident in their position as the most powerful species on the planet, but how far do we actually want to take this power? To a Brave New World (Nightmare)? And if we use new technologies to enhance the power of the few, we had better start safeguarding the future of the many.”

Google’s PoemPortraits
Our transcendence adorns,
That society of the stars seem to be the secret.

The two lines of poetry above aren’t like any poetry you’ve come across before. They are generated by an algorithm that was trained via deep learning neural networks trained on 20 million words of 19th-century poetry.

Google’s latest art project, named PoemPortraits, takes a word of your suggestion and generates a unique poem (once again, a collaboration of man and machine). You can even add a selfie in the final “PoemPortrait.” Artist Es Devlin, the project’s creator, explains that the AI “doesn’t copy or rework existing phrases, but uses its training material to build a complex statistical model. As a result, the algorithm generates original phrases emulating the style of what it’s been trained on.”

The generated poetry can sometimes be profound, and sometimes completely meaningless.But what makes the PoemPortraits project even more interesting is that it’s a collaborative project. All of the generated lines of poetry are combined to form a consistently growing collective poem, which you can view after your lines are generated. In many ways, the final collective poem is a collaboration of people from around the world working with algorithms.

Faceless Portraits Transcending Time
AICAN + Ahmed Elgammal

Image Credit: AICAN + Ahmed Elgammal | Faceless Portrait #2 (2019) | Artsy.
In March of this year, an AI artist called AICAN and its creator Ahmed Elgammal took over a New York gallery. The exhibition at HG Commentary showed two series of canvas works portraying harrowing, dream-like faceless portraits.

The exhibition was not simply credited to a machine, but rather attributed to the collaboration between a human and machine. Ahmed Elgammal is the founder and director of the Art and Artificial Intelligence Laboratory at Rutgers University. He considers AICAN to not only be an autonomous AI artist, but also a collaborator for artistic endeavors.

How did AICAN create these eerie faceless portraits? The system was presented with 100,000 photos of Western art from over five centuries, allowing it to learn the aesthetics of art via machine learning. It then drew from this historical knowledge and the mandate to create something new to create an artwork without human intervention.

Genesis
by AIVA Technologies

Listen to the score above. While you do, reflect on the fact that it was generated by an AI.

AIVA is an AI that composes soundtrack music for movies, commercials, games, and trailers. Its creative works span a wide range of emotions and moods. The scores it generates are indistinguishable from those created by the most talented human composers.

The AIVA music engine allows users to generate original scores in multiple ways. One is to upload an existing human-generated score and select the temp track to base the composition process on. Another method involves using preset algorithms to compose music in pre-defined styles, including everything from classical to Middle Eastern.

Currently, the platform is promoted as an opportunity for filmmakers and producers. But in the future, perhaps every individual will have personalized music generated for them based on their interests, tastes, and evolving moods. We already have algorithms on streaming websites recommending novel music to us based on our interests and history. Soon, algorithms may be used to generate music and other works of art that are tailored to impact our unique psyches.

The Future of Art: Pushing Our Creative Limitations
These works of art are just a glimpse into the breadth of the creative works being generated by algorithms and machines. Many of us will rightly fear these developments. We have to ask ourselves what our role will be in an era where machines are able to perform what we consider complex, abstract, creative tasks. The implications on the future of work, education, and human societies are profound.

At the same time, some of these works demonstrate that AI artists may not necessarily represent a threat to human artists, but rather an opportunity for us to push our creative boundaries. The most exciting artistic creations involve collaborations between humans and machines.

We have always used our technological scaffolding to push ourselves beyond our biological limitations. We use the telescope to extend our line of sight, planes to fly, and smartphones to connect with others. Our machines are not always working against us, but rather working as an extension of our minds. Similarly, we could use our machines to expand on our creativity and push the boundaries of art.

Image Credit: Ai-Da portraits by Nicky Johnston. Published with permission from Midas Public Relations. Continue reading →

Posted in Human Robots

#435196 Avatar Love? New ‘Black Mirror’ ...

Posted on June 17, 2019 by Android

This week, the widely-anticipated fifth season of the dystopian series Black Mirror was released on Netflix. The storylines this season are less focused on far-out scenarios and increasingly aligned with current issues. With only three episodes, this season raises more questions than it answers, often leaving audiences bewildered.

The episode Smithereens explores our society’s crippling addiction to social media platforms and the monopoly they hold over our data. In Rachel, Jack and Ashley Too, we see the disruptive impact of technologies on the music and entertainment industry, and the price of fame for artists in the digital world. Like most Black Mirror episodes, these explore the sometimes disturbing implications of tech advancements on humanity.

But once again, in the midst of all the doom and gloom, the creators of the series leave us with a glimmer of hope. Aligned with Pride month, the episode Striking Vipers explores the impact of virtual reality on love, relationships, and sexual fluidity.

*The review contains a few spoilers.*

Striking Vipers
The first episode of the season, Striking Vipers may be one of the most thought-provoking episodes in Black Mirror history. Reminiscent of previous episodes San Junipero and Hang the DJ, the writers explore the potential for technology to transform human intimacy.

The episode tells the story of two old friends, Danny and Karl, whose friendship is reignited in an unconventional way. Karl unexpectedly appears at Danny’s 38th birthday and reintroduces him to the VR version of a game they used to play years before. In the game Striking Vipers X, each of the players is represented by an avatar of their choice in an uncanny digital reality. Following old tradition, Karl chooses to become the female fighter, Roxanne, and Danny takes on the role of the male fighter, Lance. The state-of-the-art VR headsets appear to use an advanced form of brain-machine interface to allow each player to be fully immersed in the virtual world, emulating all physical sensations.

To their surprise (and confusion), Danny and Karl find themselves transitioning from fist-fighting to kissing. Over the course of many games, they continue to explore a sexual and romantic relationship in the virtual world, leaving them confused and distant in the real world. The virtual and physical realities begin to blur, and so do the identities of the players with their avatars. Danny, who is married (in a heterosexual relationship) and is a father, begins to carry guilt and confusion in the real world. They both wonder if there would be any spark between them in real life.

The brain-machine interface (BMI) depicted in the episode is still science fiction, but that hasn’t stopped innovators from pushing the technology forward. Experts today are designing more intricate BMI systems while programming better algorithms to interpret the neural signals they capture. Scientists have already succeeded in enabling paralyzed patients to type with their minds, and are even allowing people to communicate with one another purely through brainwaves.

The convergence of BMIs with virtual reality and artificial intelligence could make the experience of such immersive digital realities possible. Virtual reality, too, is decreasing exponentially in cost and increasing in quality.

The narrative provides meaningful commentary on another tech area—gaming. It highlights video games not necessarily as addictive distractions, but rather as a platform for connecting with others in a deeper way. This is already very relevant. Video games like Final Fantasy are often a tool for meaningful digital connections for their players.

The Implications of Virtual Reality on Love and Relationships
The narrative of Striking Vipers raises many novel questions about the implications of immersive technologies on relationships: could the virtual world allow us a safe space to explore suppressed desires? Can virtual avatars make it easier for us to show affection to those we care about? Can a sexual or romantic encounter in the digital world be considered infidelity?

Above all, the episode explores the therapeutic possibilities of such technologies. While many fears about virtual reality had been raised in previous seasons of Black Mirror, this episode was focused on its potential. This includes the potential of immersive technology to be a source of liberation, meaningful connections, and self-exploration, as well as a tool for realizing our true identities and desires.

Once again, this is aligned with emerging trends in VR. We are seeing the rise of social VR applications and platforms that allow you to hang out with your friends and family as avatars in the virtual space. The technology is allowing for animation movies, such as Coco VR, to become an increasingly social and interactive experience. Considering that meaningful social interaction can alleviate depression and anxiety, such applications could contribute to well-being.

Techno-philosopher and National Geographic host Jason Silva points out that immersive media technologies can be “engines of empathy.” VR allows us to enter virtual spaces that mimic someone else’s state of mind, allowing us to empathize with the way they view the world. Silva said, “Imagine the intimacy that becomes possible when people meet and they say, ‘Hey, do you want to come visit my world? Do you want to see what it’s like to be inside my head?’”

What is most fascinating about Striking Vipers is that it explores how we may redefine love with virtual reality; we are introduced to love between virtual avatars. While this kind of love may seem confusing to audiences, it may be one of the complex implications of virtual reality on human relationships.

In many ways, the title Black Mirror couldn’t be more appropriate, as each episode serves as a mirror to the most disturbing aspects of our psyches as they get amplified through technology. However, what we see in uplifting and thought-provoking plots like Striking Vipers, San Junipero, and Hang The DJ is that technology could also amplify the most positive aspects of our humanity. This includes our powerful capacity to love.

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Posted in Human Robots