Tag Archives: perspective

#437592 Coordinated Robotics Wins DARPA SubT ...

DARPA held the Virtual Cave Circuit event of the Subterranean Challenge on Tuesday in the form of a several hour-long livestream. We got to watch (along with all of the competing teams) as virtual robots explored virtual caves fully autonomously, dodging rockfalls, spotting artifacts, scoring points, and sometimes running into stuff and falling over.

Expert commentary was provided by DARPA, and we were able to watch multiple teams running at once, skipping from highlight to highlight. It was really very well done (you can watch an archive of the entire stream here), but they made us wait until the very end to learn who won: First place went to Coordinated Robotics, with BARCS taking second, and third place going to newcomer Team Dynamo.

Huge congratulations to Coordinated Robotics! It’s worth pointing out that the top three teams were separated by an incredibly small handful of points, and on a slightly different day, with slightly different artifact positions, any of them could have come out on top. This doesn’t diminish Coordinated Robotics’ victory in the least—it means that the competition was fierce, and that the problem of autonomous cave exploration with robots has been solved (virtually, at least) in several different but effective ways.

We know Coordinated Robotics pretty well at this point, but here’s an introduction video:

You heard that right—Coordinated Robotics is just Kevin Knoedler, all by himself. This would be astonishing, if we weren’t already familiar with Kevin’s abilities: He won NASA’s virtual Space Robotics Challenge by himself in 2017, and Coordinated Robotics placed first in the DARPA SubT Virtual Tunnel Circuit and second in the Virtual Urban Circuit. We asked Kevin how he managed to do so spectacularly well (again), and here’s what he told us:

IEEE Spectrum: Can you describe what it was like to watch your team of robots on the live stream, and to see them score the most points?

Kevin Knoedler: It was exciting and stressful watching the live stream. It was exciting as the top few scores were quite close for the cave circuit. It was stressful because I started out behind and worked my way up, but did not do well on the final world. Luckily, not doing well on the first and last worlds was offset by better scores on many of the runs in between. DARPA did a very nice job with their live stream of the cave circuit results.

How did you decide on the makeup of your team, and on what sensors to use?

To decide on the makeup of the team I experimented with quite a few different vehicles. I had a lot of trouble with the X2 and other small ground vehicles flipping over. Based on that I looked at the larger ground vehicles that also had a sensor capable of identifying drop-offs. The vehicles that met those criteria for me were the Marble HD2, Marble Husky, Ozbot ATR, and the Absolem. Of those ground vehicles I went with the Marble HD2. It had a downward looking depth camera that I could use to detect drop-offs and was much more stable on the varied terrain than the X2. I had used the X3 aerial vehicle before and so that was my first choice for an aerial platform.

What were some things that you learned in Tunnel and Urban that you were able to incorporate into your strategy for Cave?

In the Tunnel circuit I had learned a strategy to use ground vehicles and in the Urban circuit I had learned a strategy to use aerial vehicles. At a high level that was the biggest thing I learned from the previous circuits that I was able to apply to the Cave circuit. At a lower level I was able to apply many of the development and testing strategies from the previous circuits to the Cave circuit.

What aspect of the cave environment was most challenging for your robots?

I would say it wasn't just one aspect of the cave environment that was challenging for the robots. There were quite a few challenging aspects of the cave environment. For the ground vehicles there were frequently paths that looked good as the robot started on the path, but turned into drop-offs or difficult boulder crawls. While it was fun to see the robot plan well enough to slowly execute paths over the boulders, I was wishing that the robot was smart enough to try a different path rather than wasting so much time crawling over the large boulders. For the aerial vehicles the combination of tight paths along with large vertical spaces was the biggest challenge in the environment. The large open vertical areas were particularly challenging for my aerial robots. They could easily lose track of their position without enough nearby features to track and it was challenging to find the correct path in and out of such large vertical areas.

How will you be preparing for the SubT Final?

To prepare for the SubT Final the vehicles will be getting a lot smarter. The ground vehicles will be better at navigation and communicating with one another. The aerial vehicles will be better able to handle large vertical areas both from a positioning and a planning point of view. Finally, all of the vehicles will do a better job coordinating what areas have been explored and what areas have good leads for further exploration.

Image: DARPA

The final score for the DARPA SubT Cave Circuit virtual competition.

We also had a chance to ask SubT program manager Tim Chung a few questions at yesterday’s post-event press conference, about the course itself and what he thinks teams should have learned from the competition:

IEEE Spectrum: Having looked through some real caves, can you give some examples of some of the most significant differences between this simulation and real caves? And with the enormous variety of caves out there, how generalizable are the solutions that teams came up with?

Tim Chung: Many of the caves that I’ve had to crawl through and gotten bumps and scrapes from had a couple of different features that I’ll highlight. The first is the variations in moisture— a lot of these caves were naturally formed with streams and such, so many of the caves we went to had significant mud, flowing water, and such. And so one of the things we're not capturing in the SubT simulator is explicitly anything that would submerge the robots, or otherwise short any of their systems. So from that perspective, that's one difference that's certainly notable.

And then the other difference I think is the granularity of the terrain, whether it's rubble, sand, or just raw dirt, friction coefficients are all across the board, and I think that's one of the things that any terrestrial simulator will both struggle with and potentially benefit from— that is, terramechanics simulation abilities. Given the emphasis on mobility in the SubT simulation, we’re capturing just a sliver of the complexity of terramechanics, but I think that's probably another take away that you'll certainly see— where there’s that distinction between physical and virtual technologies.

To answer your second question about generalizability— that’s the multi-million dollar question! It’s definitely at the crux of why we have eight diverse worlds, both in size verticality, dimensions, constraint passageways, etc. But this is eight out of countless variations, and the goal of course is to be able to investigate what those key dependencies are. What I'll say is that the out of the seventy three different virtual cave tiles, which are the building blocks that make up these virtual worlds, quite a number of them were not only inspired by real world caves, but were specifically designed so that we can essentially use these tiles as unit tests going forward. So, if I want to simulate vertical inclines, here are the tiles that are the vertical vertical unit tests for robots, and that’s how we’re trying to to think through how to tease out that generalizability factor.

What are some observations from this event that you think systems track teams should pay attention to as they prepare for the final event?

One of the key things about the virtual competition is that you submit your software, and that's it. So you have to design everything from state management to failure mode triage, really thinking about what could go wrong and then building out your autonomous capabilities either to react to some of those conditions, or to anticipate them. And to be honest I think that the humans in the loop that we have in the systems competition really are key enablers of their capability, but also could someday (if not already) be a crutch that we might not be able to develop.

Thinking through some of the failure modes in a fully autonomous software deployed setting are going to be incredibly valuable for the systems competitors, so that for example the human supervisor doesn't have to worry about those failure modes as much, or can respond in a more supervisory way rather than trying to joystick the robot around. I think that's going to be one of the greatest impacts, thinking through what it means to send these robots off to autonomously get you the information you need and complete the mission

This isn’t to say that the humans aren't going to be useful and continue to play a role of course, but I think this shifting of the role of the human supervisor from being a state manager to being more of a tactical commander will dramatically highlight the impact of the virtual side on the systems side.

What, if anything, should we take away from one person teams being able to do so consistently well in the virtual circuit?

It’s a really interesting question. I think part of it has to do with systems integration versus software integration. There's something to be said for the richness of the technologies that can be developed, and how many people it requires to be able to develop some of those technologies. With the systems competitors, having one person try to build, manage, deploy, service, and operate all of those robots is still functionally quite challenging, whereas in the virtual competition, it really is a software deployment more than anything else. And so I think the commonality of single person teams may just be a virtue of the virtual competition not having some of those person-intensive requirements.

In terms of their strong performance, I give credit to all of these really talented folks who are taking upon themselves to jump into the competitor pool and see how well they do, and I think that just goes to show you that whether you're one person or ten people people or a hundred people on a team, a good idea translated and executed well really goes a long way.

Looking ahead, teams have a year to prepare for the final event, which is still scheduled to be held sometime in fall 2021. And even though there was no cave event for systems track teams, the fact that the final event will be a combination of tunnel, urban, and cave circuits means that systems track teams have been figuring out how to get their robots to work in caves anyway, and we’ll be bringing you some of their stories over the next few weeks.

[ DARPA SubT ] Continue reading

Posted in Human Robots

#437583 Video Friday: Attack of the Hexapod ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

IROS 2020 – October 25-25, 2020 – [Online]
ROS World 2020 – November 12, 2020 – [Online]
CYBATHLON 2020 – November 13-14, 2020 – [Online]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today’s videos.

Happy Halloween from HEBI Robotics!

Thanks Hardik!

[ HEBI Robotics ]

Happy Halloween from Berkshire Grey!

[ Berkshire Grey ]

These are some preliminary results of our lab’s new work on using reinforcement learning to train neural networks to imitate common bipedal gait behaviors, without using any motion capture data or reference trajectories. Our method is described in an upcoming submission to ICRA 2021. Work by Jonah Siekmann and Yesh Godse.

[ OSU DRL ]

The northern goshawk is a fast, powerful raptor that flies effortlessly through forests. This bird was the design inspiration for the next-generation drone developed by scientifics of the Laboratory of Intelligent Systems of EPFL led by Dario Floreano. They carefully studied the shape of the bird’s wings and tail and its flight behavior, and used that information to develop a drone with similar characteristics.

The engineers already designed a bird-inspired drone with morphing wing back in 2016. In a step forward, their new model can adjust the shape of its wing and tail thanks to its artificial feathers. Flying this new type of drone isn’t easy, due to the large number of wing and tail configurations possible. To take full advantage of the drone’s flight capabilities, Floreano’s team plans to incorporate artificial intelligence into the drone’s flight system so that it can fly semi-automatically. The team’s research has been published in Science Robotics.

[ EPFL ]

Oopsie.

[ Roborace ]

We’ve covered MIT’s Roboats in the past, but now they’re big enough to keep a couple of people afloat.

Self-driving boats have been able to transport small items for years, but adding human passengers has felt somewhat intangible due to the current size of the vessels. Roboat II is the “half-scale” boat in the growing body of work, and joins the previously developed quarter-scale Roboat, which is 1 meter long. The third installment, which is under construction in Amsterdam and is considered to be “full scale,” is 4 meters long and aims to carry anywhere from four to six passengers.

[ MIT ]

With a training technique commonly used to teach dogs to sit and stay, Johns Hopkins University computer scientists showed a robot how to teach itself several new tricks, including stacking blocks. With the method, the robot, named Spot, was able to learn in days what typically takes a month.

[ JHU ]

Exyn, a pioneer in autonomous aerial robot systems for complex, GPS-denied industrial environments, today announced the first dog, Kody, to successfully fly a drone at Number 9 Coal Mine, in Lansford, PA. Selected to carry out this mission was the new autonomous aerial robot, the ExynAero.

Yes, this is obviously a publicity stunt, and Kody is only flying the drone in the sense that he’s pushing the launch button and then taking a nap. But that’s also the point— drone autonomy doesn’t get much fuller than this, despite the challenge of the environment.

[ Exyn ]

In this video object instance segmentation and shape completion are combined with classical regrasp planning to perform pick-place of novel objects. It is demonstrated with a UR5, Robotiq 85 parallel-jaw gripper, and Structure depth sensor with three rearrangement tasks: bin packing (minimize the height of the packing), placing bottles onto coasters, and arrange blocks from tallest to shortest (according to the longest edge). The system also accounts for uncertainty in the segmentation/completion by avoiding grasping or placing on parts of the object where perceptual uncertainty is predicted to be high.

[ Paper ] via [ Northeastern ]

Thanks Marcus!

U can’t touch this!

[ University of Tokyo ]

We introduce a way to enable more natural interaction between humans and robots through Mixed Reality, by using a shared coordinate system. Azure Spatial Anchors, which already supports colocalizing multiple HoloLens and smartphone devices in the same space, has now been extended to support robots equipped with cameras. This allows humans and robots sharing the same space to interact naturally: humans can see the plan and intention of the robot, while the robot can interpret commands given from the person’s perspective. We hope that this can be a building block in the future of humans and robots being collaborators and coworkers.

[ Microsoft ]

Some very high jumps from the skinniest quadruped ever.

[ ODRI ]

In this video we present recent efforts to make our humanoid robot LOLA ready for multi-contact locomotion, i.e. additional hand-environment support for extra stabilization during walking.

[ TUM ]

Classic bike moves from Dr. Guero.

[ Dr. Guero ]

For a robotics company, iRobot is OLD.

[ iRobot ]

The Canadian Space Agency presents Juno, a preliminary version of a rover that could one day be sent to the Moon or Mars. Juno can navigate autonomously or be operated remotely. The Lunar Exploration Analogue Deployment (LEAD) consisted in replicating scenarios of a lunar sample return mission.

[ CSA ]

How exactly does the Waymo Driver handle a cat cutting across its driving path? Jonathan N., a Product Manager on our Perception team, breaks it all down for us.

Now do kangaroos.

[ Waymo ]

Jibo is hard at work at MIT playing games with kids.

Children’s creativity plummets as they enter elementary school. Social interactions with peers and playful environments have been shown to foster creativity in children. Digital pedagogical tools often lack the creativity benefits of co-located social interaction with peers. In this work, we leverage a social embodied robot as a playful peer and designed Escape!Bot, a game involving child-robot co-play, where the robot is a social agent that scaffolds for creativity during gameplay.

[ Paper ]

It’s nice when convenience stores are convenient even for the folks who have to do the restocking.

Who’s moving the crates around, though?

[ Telexistence ]

Hi, fans ! Join the ROS World 2020, opening November 12th , and see the footage of ROBOTIS’ ROS platform robots 🙂

[ ROS World 2020 ]

ML/RL methods are often viewed as a magical black box, and while that’s not true, learned policies are nonetheless a valuable tool that can work in conjunction with the underlying physics of the robot. In this video, Agility CTO Jonathan Hurst – wearing his professor hat at Oregon State University – presents some recent student work on using learned policies as a control method for highly dynamic legged robots.

[ Agility Robotics ]

Here’s an ICRA Legged Robots workshop talk from Marco Hutter at ETH Zürich, on Autonomy for ANYmal.

Recent advances in legged robots and their locomotion skills has led to systems that are skilled and mature enough for real-world deployment. In particular, quadrupedal robots have reached a level of mobility to navigate complex environments, which enables them to take over inspection or surveillance jobs in place like offshore industrial plants, in underground areas, or on construction sites. In this talk, I will present our research work with the quadruped ANYmal and explain some of the underlying technologies for locomotion control, environment perception, and mission autonomy. I will show how these robots can learn and plan complex maneuvers, how they can navigate through unknown environments, and how they are able to conduct surveillance, inspection, or exploration scenarios.

[ RSL ] Continue reading

Posted in Human Robots

#437562 Video Friday: Aquanaut Robot Takes to ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

IROS 2020 – October 25-25, 2020 – [Online]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Bay Area Robotics Symposium – November 20, 2020 – [Online]
ACRA 2020 – December 8-10, 2020 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.

To prepare the Perseverance rover for its date with Mars, NASA’s Mars 2020 mission team conducted a wide array of tests to help ensure a successful entry, descent and landing at the Red Planet. From parachute verification in the world’s largest wind tunnel, to hazard avoidance practice in Death Valley, California, to wheel drop testing at NASA’s Jet Propulsion Laboratory and much more, every system was put through its paces to get ready for the big day. The Perseverance rover is scheduled to land on Mars on February 18, 2021.

[ JPL ]

Awesome to see Aquanaut—the “underwater transformer” we wrote about last year—take to the ocean!

Also their new website has SHARKS on it.

[ HMI ]

Nature has inspired engineers at UNSW Sydney to develop a soft fabric robotic gripper which behaves like an elephant's trunk to grasp, pick up and release objects without breaking them.

[ UNSW ]

Collaborative robots offer increased interaction capabilities at relatively low cost but, in contrast to their industrial counterparts, they inevitably lack precision. We address this problem by relying on a dual-arm system with laser-based sensing to measure relative poses between objects of interest and compensate for pose errors coming from robot proprioception.

[ Paper ]

Developed by NAVER LABS, with Korea University of Technology & Education (Koreatech), the robot arm now features an added waist, extending the available workspace, as well as a sensor head that can perceive objects. It has also been equipped with a robot hand “BLT Gripper” that can change to various grasping methods.

[ NAVER Labs ]

In case you were still wondering why SoftBank acquired Aldebaran and Boston Dynamics:

[ RobotStart ]

DJI's new Mini 2 drone is here with a commercial so hip it makes my teeth scream.

[ DJI ]

Using simple materials, such as plastic struts and cardboard rolls, the first prototype of the RBO Hand 3 is already capable of grasping a large range of different objects thanks to its opposable thumb.

The RBO Hand 3 performs an edge grasp before handing-over the object to a person. The hand actively exploits constraints in the environment (the tabletop) for grasping the object. Thanks to its compliance, this interaction is safe and robust.

[ TU Berlin ]

Flyability's Elios 2 helped researchers inspect Reactor Five at the Chernobyl nuclear disaster site in order to determine whether any uranium was present. Prior to this mission, Reactor Five had not been investigated since the disaster in April of 1986.

[ Flyability ]

Thanks Zacc!

SOTO 2 is here! Together with our development partners from the industry, we have greatly enhanced the SOTO prototype over the last two years. With the new version of the robot, Industry 4.0 will become a great deal more real: SOTO brings materials to the assembly line, just-in-time and completely autonomously.

[ Magazino ]

A drone that can fly sustainably for long distances over land and water, and can land almost anywhere, will be able to serve a wide range of applications. There are already drones that fly using ‘green’ hydrogen, but they either fly very slowly or cannot land vertically. That’s why researchers at TU Delft, together with the Royal Netherlands Navy and the Netherlands Coastguard, developed a hydrogen-powered drone that is capable of vertical take-off and landing whilst also being able to fly horizontally efficiently for several hours, much like regular aircraft. The drone uses a combination of hydrogen and batteries as its power source.

[ MAVLab ]

The National Nuclear User Facility for Hot Robotics (NNUF-HR) is an EPSRC funded facility to support UK academia and industry to deliver ground-breaking, impactful research in robotics and artificial intelligence for application in extreme and challenging nuclear environments.

[ NNUF ]

At the Karolinska University Laboratory in Sweden, an innovation project based around an ABB collaborative robot has increased efficiency and created a better working environment for lab staff.

[ ABB ]

What I find interesting about DJI's enormous new agricultural drone is that it's got a spinning obstacle detecting sensor that's a radar, not a lidar.

Also worth noting is that it seems to detect the telephone pole, but not the support wire that you can see in the video feed, although the visualization does make it seem like it can spot the power lines above.

[ DJI ]

Josh Pieper has spend the last year building his own quadruped, and you can see what he's been up to in just 12 minutes.

[ mjbots ]

Thanks Josh!

Dr. Ryan Eustice, TRI Senior Vice President of Automated Driving, delivers a keynote speech — “The Road to Vehicle Automation, a Toyota Guardian Approach” — to SPIE's Future Sensing Technologies 2020. During the presentation, Eustice provides his perspective on the current state of automated driving, summarizes TRI's Guardian approach — which amplifies human drivers, rather than replacing them — and summarizes TRI's recent developments in core AD capabilities.

[ TRI ]

Two excellent talks this week from UPenn GRASP Lab, from Ruzena Bajcsy and Vijay Kumar.

A panel discussion on the future of robotics and societal challenges with Dr. Ruzena Bajcsy as a Roboticist and Founder of the GRASP Lab.

In this talk I will describe the role of the White House Office of Science and Technology Policy in supporting science and technology research and education, and the lessons I learned while serving in the office. I will also identify a few opportunities at the intersection of technology and policy and broad societal challenges.

[ UPenn ]

The IROS 2020 “Perception, Learning, and Control for Autonomous Agile Vehicles” workshop is all online—here's the intro, but you can click through for a playlist that includes videos of the entire program, and slides are available as well.

[ NYU ] Continue reading

Posted in Human Robots

#437150 AI Is Getting More Creative. But Who ...

Creativity is a trait that makes humans unique from other species. We alone have the ability to make music and art that speak to our experiences or illuminate truths about our world. But suddenly, humans’ artistic abilities have some competition—and from a decidedly non-human source.

Over the last couple years there have been some remarkable examples of art produced by deep learning algorithms. They have challenged the notion of an elusive definition of creativity and put into perspective how professionals can use artificial intelligence to enhance their abilities and produce beyond the known boundaries.

But when creativity is the result of code written by a programmer, using a format given by a software engineer, featuring private and public datasets, how do we assign ownership of AI-generated content, and particularly that of artwork? McKinsey estimates AI will annually generate value of $3.5 to $5.8 trillion across various sectors.

In 2018, a portrait that was christened Edmond de Belamy was made in a French art collective called Obvious. It used a database with 15,000 portraits from the 1300s to the 1900s to train a deep learning algorithm to produce a unique portrait. The painting sold for $432,500 in a New York auction. Similarly, a program called Aiva, trained on thousands of classical compositions, has released albums whose pieces are being used by ad agencies and movies.

The datasets used by these algorithms were different, but behind both there was a programmer who changed the brush strokes or musical notes into lines of code and a data scientist or engineer who fitted and “curated” the datasets to use for the model. There could also have been user-based input, and the output may be biased towards certain styles or unintentionally infringe on similar pieces of art. This shows that there are many collaborators with distinct roles in producing AI-generated content, and it’s important to discuss how they can protect their proprietary interests.

A perspective article published in Nature Machine Intelligence by Jason K. Eshraghian in March looks into how AI artists and the collaborators involved should assess their ownership, laying out some guiding principles that are “only applicable for as long as AI does not have legal parenthood, the way humans and corporations are accorded.”

Before looking at how collaborators can protect their interests, it’s useful to understand the basic requirements of copyright law. The artwork in question must be an “original work of authorship fixed in a tangible medium.” Given this principle, the author asked whether it’s possible for AI to exercise creativity, skill, or any other indicator of originality. The answer is still straightforward—no—or at least not yet. Currently, AI’s range of creativity doesn’t exceed the standard used by the US Copyright Office, which states that copyright law protects the “fruits of intellectual labor founded in the creative powers of the mind.”

Due to the current limitations of narrow AI, it must have some form of initial input that helps develop its ability to create. At the moment AI is a tool that can be used to produce creative work in the same way that a video camera is a tool used to film creative content. Video producers don’t need to comprehend the inner workings of their cameras; as long as their content shows creativity and originality, they have a proprietary claim over their creations.

The same concept applies to programmers developing a neural network. As long as the dataset they use as input yields an original and creative result, it will be protected by copyright law; they don’t need to understand the high-level mathematics, which in this case are often black box algorithms whose output it’s impossible to analyze.

Will robots and algorithms eventually be treated as creative sources able to own copyrights? The author pointed to the recent patent case of Warner-Lambert Co Ltd versus Generics where Lord Briggs, Justice of the Supreme Court of the UK, determined that “the court is well versed in identifying the governing mind of a corporation and, when the need arises, will no doubt be able to do the same for robots.”

In the meantime, Dr. Eshraghian suggests four guiding principles to allow artists who collaborate with AI to protect themselves.

First, programmers need to document their process through online code repositories like GitHub or BitBucket.

Second, data engineers should also document and catalog their datasets and the process they used to curate their models, indicating selectivity in their criteria as much as possible to demonstrate their involvement and creativity.

Third, in cases where user data is utilized, the engineer should “catalog all runs of the program” to distinguish the data selection process. This could be interpreted as a way of determining whether user-based input has a right to claim the copyright too.

Finally, the output should avoid infringing on others’ content through methods like reverse image searches and version control, as mentioned above.

AI-generated artwork is still a very new concept, and the ambiguous copyright laws around it give a lot of flexibility to AI artists and programmers worldwide. The guiding principles Eshraghian lays out will hopefully shed some light on the legislation we’ll eventually need for this kind of art, and start an important conversation between all the stakeholders involved.

Image Credit: Wikimedia Commons Continue reading

Posted in Human Robots

#436962 Scientists Engineered Neurons to Make ...

Electricity plays a surprisingly powerful role in our bodies. While most people are aware that it plays a crucial role in carrying signals to and from our nerves, our bodies produce electric fields that can do everything from helping heal wounds to triggering the release of hormones.

Electric fields can influence a host of important cellular behavior, like directional migration, proliferation, division, or even differentiation into different cell types. The work of Michael Levin at Tufts University even suggests that electrical fields may play a crucial role in the way our bodies organize themselves.

This has prompted considerable interest in exploiting our body’s receptiveness to electrical stimulation for therapeutic means, but given the diffuse nature of electrical fields a key challenge is finding a way to localize these effects. Conductive polymers have proven a useful tool in this regard thanks to their good electrical properties and biocompatibility, and have been used in everything from neural implants to biosensors.

But now, a team at Stanford University has developed a way to genetically engineer neurons to build the materials into their own cell membranes. The approach could make it possible to target highly specific groups of cells, providing unprecedented control over the body’s response to electrical stimulation.

In a paper in Science, the team explained how they used re-engineered viruses to deliver DNA that hijacks cells’ biosynthesis machinery to create an enzyme that assembles electroactive polymers onto their membranes. This changes the electrical properties of the cells, which the team demonstrated could be used to control their behavior.

They used the approach to modulate neuronal firing in cultures of rat hippocampal neurons, mouse brain slices, and even human cortical spheroids. Most impressively, they showed that they could coax the neurons of living C. elegans worms to produce the polymers in large enough quantities to alter their behavior without impairing the cells’ natural function.

Translating the idea to humans poses major challenges, not least because the viruses used to deliver the genetic changes are still a long way from being approved for clinical use. But the ability to precisely target specific cells using a genetic approach holds enormous promise for bioelectronic medicine, Kevin Otto and Christine Schmidt from the University of Florida say in an accompanying perspective.

Interest is booming in therapies that use electrical stimulation of neural circuits as an alternative to drugs for diseases as varied as arthritis, Alzheimer’s, diabetes, and cardiovascular disease, and hundreds of clinical trials are currently underway.

At present these approaches rely on electrodes that can provide some level of localization, but because different kinds of nerve cells are often packed closely together it’s proven hard to stimulate exactly the right nerves, say Otto and Schmidt. This new approach makes it possible to boost the conductivity of specific cell types, which could make these kinds of interventions dramatically more targeted.

Besides disease-focused bioelectronic interventions, Otto and Schmidt say the approach could prove invaluable for helping to interface advanced prosthetics with patients’ nervous systems by making it possible to excite sensory neurons without accidentally triggering motor neurons, or vice versa.

More speculatively, the approach could one day help create far more efficient bridges between our minds and machines. One of the major challenges for brain-machine interfaces is recording from specific neurons, something that a genetically targeted approach might be able to help greatly with.

If the researchers can replicate the ability to build electronic-tissue “composites” in humans, we may be well on our way to the cyborg future predicted by science fiction.

Image Credit: Gerd Altmann from Pixabay Continue reading

Posted in Human Robots