Tag Archives: patients

#439691 Researchers develop bionic arm that ...

Cleveland Clinic researchers have engineered a first-of-its-kind bionic arm for patients with upper-limb amputations that allows wearers to think, behave and function like a person without an amputation, according to new findings published in Science Robotics. Continue reading

Posted in Human Robots

#439077 How Scientists Grew Human Muscles in Pig ...

The little pigs bouncing around the lab looked exceedingly normal. Yet their adorable exterior hid a remarkable secret: each piglet carried two different sets of genes. For now, both sets came from their own species. But one day, one of those sets may be human.

The piglets are chimeras—creatures with intermingled sets of genes, as if multiple entities were seamlessly mashed together. Named after the Greek lion-goat-serpent monsters, chimeras may hold the key to an endless supply of human organs and tissues for transplant. The crux is growing these human parts in another animal—one close enough in size and function to our own.

Last week, a team from the University of Minnesota unveiled two mind-bending chimeras. One was joyous little piglets, each propelled by muscles grown from a different pig. Another was pig embryos, transplanted into surrogate pigs, that developed human muscles for more than 20 days.

The study, led by Drs. Mary and Daniel Garry at the University of Minnesota, had a therapeutic point: engineering a brilliant way to replace muscle loss, especially for the muscles around our skeletons that allow us to move and navigate the world. Trauma and injury, such as from firearm wounds or car crashes, can damage muscle tissue beyond the point of repair. Unfortunately, muscles are also stubborn in that donor tissue from cadavers doesn’t usually “take” at the injury site. For now, there are no effective treatments for severe muscle death, called volumetric muscle loss.

The new human-pig hybrids are designed to tackle this problem. Muscle wasting aside, the study also points to a clever “hack” that increases the amount of human tissue inside a growing pig embryo.

If further improved, the technology could “provide an unlimited supply of organs for transplantation,” said Dr. Mary Garry to Inverse. What’s more, because the human tissue can be sourced from patients themselves, the risk of rejection by the immune system is relatively low—even when grown inside a pig.

“The shortage of organs for heart transplantation, vascular grafting, and skeletal muscle is staggering,” said Garry. Human-animal chimeras could have a “seismic impact” that transforms organ transplantation and helps solve the organ shortage crisis.

That is, if society accepts the idea of a semi-humanoid pig.

Wait…But How?
The new study took a page from previous chimera recipes.

The main ingredients and steps go like this: first, you need an embryo that lacks the ability to develop a tissue or organ. This leaves an “empty slot” of sorts that you can fill with another set of genes—pig, human, or even monkey.

Second, you need to fine-tune the recipe so that the embryos “take” the new genes, incorporating them into their bodies as if they were their own. Third, the new genes activate to instruct the growing embryo to make the necessary tissue or organs without harming the overall animal. Finally, the foreign genes need to stay put, without cells migrating to another body part—say, the brain.

Not exactly straightforward, eh? The piglets are technological wonders that mix cutting-edge gene editing with cloning technologies.

The team went for two chimeras: one with two sets of pig genes, the other with a pig and human mix. Both started with a pig embryo that can’t make its own skeletal muscles (those are the muscles surrounding your bones). Using CRISPR, the gene-editing Swiss Army Knife, they snipped out three genes that are absolutely necessary for those muscles to develop. Like hitting a bullseye with three arrows simultaneously, it’s already a technological feat.

Here’s the really clever part: the muscles around your bones have a slightly different genetic makeup than the ones that line your blood vessels or the ones that pump your heart. While the resulting pig embryos had severe muscle deformities as they developed, their hearts beat as normal. This means the gene editing cut only impacted skeletal muscles.

Then came step two: replacing the missing genes. Using a microneedle, the team injected a fertilized and slightly developed pig egg—called a blastomere—into the embryo. If left on its natural course, a blastomere eventually develops into another embryo. This step “smashes” the two sets of genes together, with the newcomer filling the muscle void. The hybrid embryo was then placed into a surrogate, and roughly four months later, chimeric piglets were born.

Equipped with foreign DNA, the little guys nevertheless seemed totally normal, nosing around the lab and running everywhere without obvious clumsy stumbles. Under the microscope, their “xenomorph” muscles were indistinguishable from run-of-the-mill average muscle tissue—no signs of damage or inflammation, and as stretchy and tough as muscles usually are. What’s more, the foreign DNA seemed to have only developed into muscles, even though they were prevalent across the body. Extensive fishing experiments found no trace of the injected set of genes inside blood vessels or the brain.

A Better Human-Pig Hybrid
Confident in their recipe, the team next repeated the experiment with human cells, with a twist. Instead of using controversial human embryonic stem cells, which are obtained from aborted fetuses, they relied on induced pluripotent stem cells (iPSCs). These are skin cells that have been reverted back into a stem cell state.

Unlike previous attempts at making human chimeras, the team then scoured the genetic landscape of how pig and human embryos develop to find any genetic “brakes” that could derail the process. One gene, TP53, stood out, which was then promptly eliminated with CRISPR.

This approach provides a way for future studies to similarly increase the efficiency of interspecies chimeras, the team said.

The human-pig embryos were then carefully grown inside surrogate pigs for less than a month, and extensively analyzed. By day 20, the hybrids had already grown detectable human skeletal muscle. Similar to the pig-pig chimeras, the team didn’t detect any signs that the human genes had sprouted cells that would eventually become neurons or other non-muscle cells.

For now, human-animal chimeras are not allowed to grow to term, in part to stem the theoretical possibility of engineering humanoid hybrid animals (shudder). However, a sentient human-pig chimera is something that the team specifically addressed. Through multiple experiments, they found no trace of human genes in the embryos’ brain stem cells 20 and 27 days into development. Similarly, human donor genes were absent in cells that would become the hybrid embryos’ reproductive cells.

Despite bioethical quandaries and legal restrictions, human-animal chimeras have taken off, both as a source of insight into human brain development and a well of personalized organs and tissues for transplant. In 2019, Japan lifted its ban on developing human brain cells inside animal embryos, as well as the term limit—to global controversy. There’s also the question of animal welfare, given that hybrid clones will essentially become involuntary organ donors.

As the debates rage on, scientists are nevertheless pushing the limits of human-animal chimeras, while treading as carefully as possible.

“Our data…support the feasibility of the generation of these interspecies chimeras, which will serve as a model for translational research or, one day, as a source for xenotransplantation,” the team said.

Image Credit: Christopher Carson on Unsplash Continue reading

Posted in Human Robots

#438731 Video Friday: Perseverance Lands on Mars

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
ICRA 2021 – May 30-5, 2021 – Xi'an, China
Let us know if you have suggestions for next week, and enjoy today's videos.

Hmm, did anything interesting happen in robotics yesterday week?

Obviously, we're going to have tons more on the Mars Rover and Mars Helicopter over the next days, weeks, months, years, and (if JPL's track record has anything to say about it) decades. Meantime, here's what's going to happen over the next day or two:

[ Mars 2020 ]

PLEN hopes you had a happy Valentine's Day!

[ PLEN ]

Unitree dressed up a whole bunch of Laikago quadrupeds to take part in the 2021 Spring Festival Gala in China.

[ Unitree ]

Thanks Xingxing!

Marine iguanas compete for the best nesting sites on the Galapagos Islands. Meanwhile RoboSpy Iguana gets involved in a snot sneezing competition after the marine iguanas return from the sea.

[ Spy in the Wild ]

Tails, it turns out, are useful for almost everything.

[ DART Lab ]

Partnered with MD-TEC, this video demonstrates use of teleoperated robotic arms and virtual reality interface to perform closed suction for self-ventilating tracheostomy patients during COVID -19 outbreak. Use of closed suction is recommended to minimise aerosol generated during this procedure. This robotic method avoids staff exposure to virus to further protect NHS.

[ Extend Robotics ]

Fotokite is a safe, practical way to do local surveillance with a drone.

I just wish they still had a consumer version 🙁

[ Fotokite ]

How to confuse fish.

[ Harvard ]

Army researchers recently expanded their research area for robotics to a site just north of Baltimore. Earlier this year, Army researchers performed the first fully-autonomous tests onsite using an unmanned ground vehicle test bed platform, which serves as the standard baseline configuration for multiple programmatic efforts within the laboratory. As a means to transition from simulation-based testing, the primary purpose of this test event was to capture relevant data in a live, operationally-relevant environment.

[ Army ]

Flexiv's new RIZON 10 robot hopes you had a happy Valentine's Day!

[ Flexiv ]

Thanks Yunfan!

An inchworm-inspired crawling robot (iCrawl) is a 5 DOF robot with two legs; each with an electromagnetic foot to crawl on the metal pipe surfaces. The robot uses a passive foot-cap underneath an electromagnetic foot, enabling it to be a versatile pipe-crawler. The robot has the ability to crawl on the metal pipes of various curvatures in horizontal and vertical directions. The robot can be used as a new robotic solution to assist close inspection outside the pipelines, thus minimizing downtime in the oil and gas industry.

[ Paper ]

Thanks Poramate!

A short film about Robot Wars from Blender Magazine in 1995.

[ YouTube ]

While modern cameras provide machines with a very well-developed sense of vision, robots still lack such a comprehensive solution for their sense of touch. The talk will present examples of why the sense of touch can prove crucial for a wide range of robotic applications, and a tech demo will introduce a novel sensing technology targeting the next generation of soft robotic skins. The prototype of the tactile sensor developed at ETH Zurich exploits the advances in camera technology to reconstruct the forces applied to a soft membrane. This technology has the potential to revolutionize robotic manipulation, human-robot interaction, and prosthetics.

[ ETHZ ]

Thanks Markus!

Quadrupedal robotics has reached a level of performance and maturity that enables some of the most advanced real-world applications with autonomous mobile robots. Driven by excellent research in academia and industry all around the world, a growing number of platforms with different skills target different applications and markets. We have invited a selection of experts with long-standing experience in this vibrant research area

[ IFRR ]

Thanks Fan!

Since January 2020, more than 300 different robots in over 40 countries have been used to cope with some aspect of the impact of the coronavirus pandemic on society. The majority of these robots have been used to support clinical care and public safety, allowing responders to work safely and to handle the surge in infections. This panel will discuss how robots have been successfully used and what is needed, both in terms of fundamental research and policy, for robotics to be prepared for the future emergencies.

[ IFRR ]

At Skydio, we ship autonomous robots that are flown at scale in complex, unknown environments every day. We’ve invested six years of R&D into handling extreme visual scenarios not typically considered by academia nor encountered by cars, ground robots, or AR applications. Drones are commonly in scenes with few or no semantic priors on the environment and must deftly navigate thin objects, extreme lighting, camera artifacts, motion blur, textureless surfaces, vibrations, dirt, smudges, and fog. These challenges are daunting for classical vision, because photometric signals are simply inconsistent. And yet, there is no ground truth for direct supervision of deep networks. We’ll take a detailed look at these issues and how we’ve tackled them to push the state of the art in visual inertial navigation, obstacle avoidance, rapid trajectory planning. We will also cover the new capabilities on top of our core navigation engine to autonomously map complex scenes and capture all surfaces, by performing real-time 3D reconstruction across multiple flights.

[ UPenn ] Continue reading

Posted in Human Robots

#438294 Video Friday: New Entertainment Robot ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
ICRA 2021 – May 30-5, 2021 – Xi'an, China
Let us know if you have suggestions for next week, and enjoy today's videos.

Engineered Arts' latest Mesmer entertainment robot is Cleo. It sings, gesticulates, and even does impressions.

[ Engineered Arts ]

I do not know what this thing is or what it's saying but Panasonic is going to be selling them and I will pay WHATEVER. IT. COSTS.

Slightly worrisome is that Google Translate persistently thinks that part of the description involves “sleeping and flatulence.”

[ Panasonic ] via [ RobotStart ]

Spot Enterprise is here to help you safely ignore every alarm that goes off at work while you're snug at home in your jammies drinking cocoa.

That Spot needs a bath.

If you missed the launch event (with more on the arm), check it out here:

[ Boston Dynamics ]

PHASA-35, a 35m wingspan solar-electric aircraft successfully completed its maiden flight in Australia, February 2020. Designed to operate unmanned in the stratosphere, above the weather and conventional air traffic, PHASA-35 offers a persistent and affordable alternative to satellites combined with the flexibility of an aircraft, which could be used for a range of valuable applications including forest fire detection and maritime surveillance.

[ BAE Systems ]

As part of the Army Research Lab’s (ARL) Robotics Collaborative Technology Alliance (RCTA), we are developing new planning and control algorithms for quadrupedal robots. The goal of our project is to equip the robot LLAMA, developed by NASA JPL, with the skills it needs to move at operational tempo over difficult terrain to keep up with a human squad. This requires innovative perception, planning, and control techniques to make the robot both precise in execution for navigating technical obstacles and robust enough to reject disturbances and recover from unknown errors.

[ IHMC ]

Watch what happens to this drone when it tries to install a bird diverter on a high voltage power line:

[ GRVC ]

Soldiers navigate a wide variety of terrains to successfully complete their missions. As human/agent teaming and artificial intelligence advance, the same flexibility will be required of robots to maneuver across diverse terrain and become effective combat teammates.

[ Army ]

The goal of the GRIFFIN project is to create something similar to sort of robotic bird, which almost certainly won't look like this concept rendering.

While I think this research is great, at what point is it in fact easier to just, you know, train an actual bird?

[ GRIFFIN ]

Paul Newman narrates this video from two decades ago, which is a pretty neat trick.

[ Oxford Robotics Institute ]

The first step towards a LEGO-based robotic McMuffin creator is cracking and separating eggs.

[ Astonishing Studios ] via [ BB ]

Some interesting soft robotics projects at the University of Southern Denmark.

[ SDU ]

Chong Liu introduces Creature_02, his final presentation for Hod Lipson's Robotics Studio course at Columbia.

[ Chong Liu ]

The world needs more robot blimps.

[ Lab INIT Robots ]

Finishing its duty early, the KR CYBERTECH nano uses this time to play basketball.

[ Kuka ]

senseFly has a new aerial surveying drone that they call “affordable,” although they don't say what the price is.

[ senseFly ]

In summer 2020 participated several science teams of the ETH Zurich at the “Art Safiental” in the mountains of Graubunden. After the scientists packed their hiking gear and their robots, their only mission was “over hill and dale to the summit”. How difficult will it be to reach the summit with a legged robot and an exosceletton? What's the relation of synesthetic dance and robotic? How will the hikers react to these projects?

[ Rienerschnitzel Films ]

Thanks Robert!

Karen Liu: How robots perceive the physical world. A specialist in computer animation expounds upon her rapidly evolving specialty, known as physics-based simulation, and how it is helping robots become more physically aware of the world around them.

[ Stanford ]

This week's UPenn GRASP On Robotics seminar is by Maria Chiara Carrozza from Scuola Superiore Sant’Anna, on “Biorobotics for Personal Assistance – Translational Research and Opportunities for Human-Centered Developments.”

The seminar will focus on the opportunities and challenges offered by the digital transformation of healthcare which was accelerated in the COVID-19 Pandemia. In this framework rehabilitation and social robotics can play a fundamental role as enabling technologies for providing innovative therapies and services to patients even at home or in remote environments.

[ UPenn ] Continue reading

Posted in Human Robots

#437990 Video Friday: Record-Breaking Drone Show ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online]
RoboSoft 2021 – April 12-16, 2021 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.

A new parent STAR robot is presented. The parent robot has a tail on which the child robot can climb. By collaborating together, the two robots can reach locations that neither can reach on its own.

The parent robot can also supply the child robot with energy by recharging its batteries. The parent STAR can dispatch and recuperate the child STAR automatically (when aligned). The robots are fitted with sensors and controllers and have automatic capabilities but make no decisions on their own.

[ Bio-Inspired and Medical Robotics Lab ]

How TRI trains its robots.

[ TRI ]

The only thing more satisfying than one SCARA robot is two SCARA robots working together.

[ Fanuc ]

I'm not sure that this is strictly robotics, but it's so cool that it's worth a watch anyway.

[ Shinoda & Makino Lab ]

Flying insects heavily rely on optical flow for visual navigation and flight control. Roboticists have endowed small flying robots with optical flow control as well, since it requires just a tiny vision sensor. However, when using optical flow, the robots run into two problems that insects appear to have overcome. Firstly, since optical flow only provides mixed information on distances and velocities, using it for control leads to oscillations when getting closer to obstacles. Secondly, since optical flow provides very little information on obstacles in the direction of motion, it is hardest to detect obstacles that the robot is actually going to collide with! We propose a solution to these problems by means of a learning process.

[ Nature ]

A new Guinness World Record was set on Friday in north China for the longest animation performed by 600 unmanned aerial vehicles (UAVs).

[ Xinhua ]

Translucency is prevalent in everyday scenes. As such, perception of transparent objects is essential for robots to perform manipulation. In this work, we propose LIT, a two-stage method for transparent object pose estimation using light-field sensing and photorealistic rendering.

[ University of Michigan ] via [ Fetch Robotics ]

This paper reports the technological progress and performance of team “CERBERUS” after participating in the Tunnel and Urban Circuits of the DARPA Subterranean Challenge.

And here's a video report on the SubT Urban Beta Course performance:

[ CERBERUS ]

Congrats to Energy Robotics on 2 million euros in seed funding!

[ Energy Robotics ]

Thanks Stefan!

In just 2 minutes, watch HEBI robotics spending 23 minutes assembling a robot arm.

HEBI Robotics is hosting a webinar called 'Redefining the Robotic Arm' next week, which you can check out at the link below.

[ HEBI Robotics ]

Thanks Hardik!

Achieving versatile robot locomotion requires motor skills which can adapt to previously unseen situations. We propose a Multi-Expert Learning Architecture (MELA) that learns to generate adaptive skills from a group of representative expert skills. During training, MELA is first initialised by a distinct set of pre-trained experts, each in a separate deep neural network (DNN). Then by learning the combination of these DNNs using a Gating Neural Network (GNN), MELA can acquire more specialised experts and transitional skills across various locomotion modes.

[ Paper ]

Since the dawn of history, advances in science and technology have pursued “power” and “accuracy.” Initially, “hardness” in machines and materials was sought for reliable operations. In our area of Science of Soft Robots, we have combined emerging academic fields aimed at “softness” to increase the exposure and collaboration of researchers in different fields.

[ Science of Soft Robots ]

A team from the Laboratory of Robotics and IoT for Smart Precision Agriculture and Forestry at INESC TEC – Technology and Science are creating a ROS stack solution using Husky UGV for precision field crop agriculture.

[ Clearpath Robotics ]

Associate Professor Christopher J. Hasson in the Department of Physical Therapy is the director Neuromotor Systems Laboratory at Northeastern University. There he is working with a robotic arm to provide enhanced assistance to physical therapy patients, while maintaining the intimate therapist and patient relationship.

[ Northeastern ]

Mobile Robotic telePresence (MRP) systems aim to support enhanced collaboration between remote and local members of a given setting. But MRP systems also put the remote user in positions where they frequently rely on the help of local partners. Getting or ‘recruiting’ such help can be done with various verbal and embodied actions ranging in explicitness. In this paper, we look at how such recruitment occurs in video data drawn from an experiment where pairs of participants (one local, one remote) performed a timed searching task.

[ Microsoft Research ]

A presentation [from Team COSTAR] for the American Geophysical Union annual fall meeting on the application of robotic multi-sensor 3D Mapping for scientific exploration of caves. Lidar-based 3D maps are combined with visual/thermal/spectral/gas sensors to provide rich 3D context for scientific measurements map.

[ COSTAR ] Continue reading

Posted in Human Robots