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#439042 How Scientists Used Ultrasound to Read ...
Thanks to neural implants, mind reading is no longer science fiction.
As I’m writing this sentence, a tiny chip with arrays of electrodes could sit on my brain, listening in on the crackling of my neurons firing as my hands dance across the keyboard. Sophisticated algorithms could then decode these electrical signals in real time. My brain’s inner language to plan and move my fingers could then be used to guide a robotic hand to do the same. Mind-to-machine control, voilà!
Yet as the name implies, even the most advanced neural implant has a problem: it’s an implant. For electrodes to reliably read the brain’s electrical chatter, they need to pierce through the its protective membrane and into brain tissue. Danger of infection aside, over time, damage accumulates around the electrodes, distorting their signals or even rendering them unusable.
Now, researchers from Caltech have paved a way to read the brain without any physical contact. Key to their device is a relatively new superstar in neuroscience: functional ultrasound, which uses sound waves to capture activity in the brain.
In monkeys, the technology could reliably predict their eye movement and hand gestures after just a single trial—without the usual lengthy training process needed to decode a movement. If adopted by humans, the new mind-reading tech represents a triple triumph: it requires minimal surgery and minimal learning, but yields maximal resolution for brain decoding. For people who are paralyzed, it could be a paradigm shift in how they control their prosthetics.
“We pushed the limits of ultrasound neuroimaging and were thrilled that it could predict movement,” said study author Dr. Sumner Norman.
To Dr. Krishna Shenoy at Stanford, who was not involved, the study will finally put ultrasound “on the map as a brain-machine interface technique. Adding to this toolkit is spectacular,” he said.
Breaking the Sound Barrier
Using sound to decode brain activity might seem preposterous, but ultrasound has had quite the run in medicine. You’ve probably heard of its most common use: taking photos of a fetus in pregnancy. The technique uses a transducer, which emits ultrasound pulses into the body and finds boundaries in tissue structure by analyzing the sound waves that bounce back.
Roughly a decade ago, neuroscientists realized they could adapt the tech for brain scanning. Rather than directly measuring the brain’s electrical chatter, it looks at a proxy—blood flow. When certain brain regions or circuits are active, the brain requires much more energy, which is provided by increased blood flow. In this way, functional ultrasound works similarly to functional MRI, but at a far higher resolution—roughly ten times, the authors said. Plus, people don’t have to lie very still in an expensive, claustrophobic magnet.
“A key question in this work was: If we have a technique like functional ultrasound that gives us high-resolution images of the brain’s blood flow dynamics in space and over time, is there enough information from that imaging to decode something useful about behavior?” said study author Dr. Mikhail Shapiro.
There’s plenty of reasons for doubt. As the new kid on the block, functional ultrasound has some known drawbacks. A major one: it gives a far less direct signal than electrodes. Previous studies show that, with multiple measurements, it can provide a rough picture of brain activity. But is that enough detail to guide a robotic prosthesis?
One-Trial Wonder
The new study put functional ultrasound to the ultimate test: could it reliably detect movement intention in monkeys? Because their brains are the most similar to ours, rhesus macaque monkeys are often the critical step before a brain-machine interface technology is adapted for humans.
The team first inserted small ultrasound transducers into the skulls of two rhesus monkeys. While it sounds intense, the surgery doesn’t penetrate the brain or its protective membrane; it’s only on the skull. Compared to electrodes, this means the brain itself isn’t physically harmed.
The device is linked to a computer, which controls the direction of sound waves and captures signals from the brain. For this study, the team aimed the pulses at the posterior parietal cortex, a part of the “motor” aspect of the brain, which plans movement. If right now you’re thinking about scrolling down this page, that’s the brain region already activated, before your fingers actually perform the movement.
Then came the tests. The first looked at eye movements—something pretty necessary before planning actual body movements without tripping all over the place. Here, the monkeys learned to focus on a central dot on a computer screen. A second dot, either left or right, then flashed. The monkeys’ task was to flicker their eyes to the most recent dot. It’s something that seems easy for us, but requires sophisticated brain computation.
The second task was more straightforward. Rather than just moving their eyes to the second target dot, the monkeys learned to grab and manipulate a joystick to move a cursor to that target.
Using brain imaging to decode the mind and control movement. Image Credit: S. Norman, Caltech
As the monkeys learned, so did the device. Ultrasound data capturing brain activity was fed into a sophisticated machine learning algorithm to guess the monkeys’ intentions. Here’s the kicker: once trained, using data from just a single trial, the algorithm was able to correctly predict the monkeys’ actual eye movement—whether left or right—with roughly 78 percent accuracy. The accuracy for correctly maneuvering the joystick was even higher, at nearly 90 percent.
That’s crazy accurate, and very much needed for a mind-controlled prosthetic. If you’re using a mind-controlled cursor or limb, the last thing you’d want is to have to imagine the movement multiple times before you actually click the web button, grab the door handle, or move your robotic leg.
Even more impressive is the resolution. Sound waves seem omnipresent, but with focused ultrasound, it’s possible to measure brain activity at a resolution of 100 microns—roughly 10 neurons in the brain.
A Cyborg Future?
Before you start worrying about scientists blasting your brain with sound waves to hack your mind, don’t worry. The new tech still requires skull surgery, meaning that a small chunk of skull needs to be removed. However, the brain itself is spared. This means that compared to electrodes, ultrasound could offer less damage and potentially a far longer mind reading than anything currently possible.
There are downsides. Focused ultrasound is far younger than any electrode-based neural implants, and can’t yet reliably decode 360-degree movement or fine finger movements. For now, the tech requires a wire to link the device to a computer, which is off-putting to many people and will prevent widespread adoption. Add to that the inherent downside of focused ultrasound, which lags behind electrical recordings by roughly two seconds.
All that aside, however, the tech is just tiptoeing into a future where minds and machines seamlessly connect. Ultrasound can penetrate the skull, though not yet at the resolution needed for imaging and decoding brain activity. The team is already working with human volunteers with traumatic brain injuries, who had to have a piece of their skulls removed, to see how well ultrasound works for reading their minds.
“What’s most exciting is that functional ultrasound is a young technique with huge potential. This is just our first step in bringing high performance, less invasive brain-machine interface to more people,” said Norman.
Image Credit: Free-Photos / Pixabay Continue reading
Posted in Human Robots
#439032 To Learn To Deal With Uncertainty, This ...
AI is endowing robots, autonomous vehicles and countless of other forms of tech with new abilities and levels of self-sufficiency. Yet these models faithfully “make decisions” based on whatever data is fed into them, which could have dangerous consequences. For instance, if an autonomous car is driving down a highway and the sensor picks up a confusing signal (e.g., a paint smudge that is incorrectly interpreted as a lane marking), this could cause the car to swerve into another lane unnecessarily.
But in the ever-evolving world of AI, researchers are developing new ways to address challenges like this. One group of researchers has devised a new algorithm that allows the AI model to account for uncertain data, which they describe in a study published February 15 in IEEE Transactions on Neural Networks and Learning Systems.
“While we would like robots to work seamlessly in the real world, the real world is full of uncertainty,” says Michael Everett, a post-doctoral associate at MIT who helped develop the new approach. “It's important for a system to be aware of what it knows and what it is unsure about, which has been a major challenge for modern AI.”
His team focused on a type of AI called reinforcement learning (RL), whereby the model tries to learn the “value” of taking each action in a given scenario through trial-and-error. They developed a secondary algorithm, called Certified Adversarial Robustness for deep RL (CARRL), that can be built on top of an existing RL model.
“Our key innovation is that rather than blindly trusting the measurements, as is done today [by AI models], our algorithm CARRL thinks through all possible measurements that could have been made, and makes a decision that considers the worst-case outcome,” explains Everett.
In their study, the researchers tested CARRL across several different tasks, including collision avoidance simulations and Atari pong. For younger readers who may not be familiar with it, Atari pong is a classic computer game whereby an electronic paddle is used to direct a ping pong on the screen. In the test scenario, CARRL helped move the paddle slightly higher or lower to compensate for the possibility that the ball could approach at a slightly different point than what the input data indicated. All the while, CARRL would try to ensure that the ball would make contact with at least some part of paddle.
Gif: MIT Aerospace Controls Laboratory
In a perfect world, the information that an AI model is fed would be accurate all the time and AI model will perform well (left). But in some cases, the AI may be given inaccurate data, causing it to miss its targets (middle). The new algorithm CARRL helps AIs account for uncertainty in its data inputs, yielding a better performance when relying on poor data (right).
Across all test scenarios, the RL model was better at compensating for potential inaccurate or “noisy” data with CARRL, than without CARRL.
But the results also show that, like with humans, too much self-doubt and uncertainty can be unhelpful. In the collision avoidance scenario, for example, indulging in too much uncertainty caused the main moving object in the simulation to avoid both the obstacle and its goal. “There is definitely a limit to how ‘skeptical’ the algorithm can be without becoming overly conservative,” Everett says.
This research was funded by Ford Motor Company, but Everett notes that it could be applicable under many other commercial applications requiring safety-aware AI, including aerospace, healthcare, or manufacturing domains.
“This work is a step toward my vision of creating ‘certifiable learning machines’—systems that can discover how to explore and perform in the real world on their own, while still having safety and robustness guarantees,” says Everett. “We'd like to bring CARRL into robotic hardware while continuing to explore the theoretical challenges at the interface of robotics and AI.” Continue reading
Posted in Human Robots