Tag Archives: muscles
#439110 Robotic Exoskeletons Could One Day Walk ...
Engineers, using artificial intelligence and wearable cameras, now aim to help robotic exoskeletons walk by themselves.
Increasingly, researchers around the world are developing lower-body exoskeletons to help people walk. These are essentially walking robots users can strap to their legs to help them move.
One problem with such exoskeletons: They often depend on manual controls to switch from one mode of locomotion to another, such as from sitting to standing, or standing to walking, or walking on the ground to walking up or down stairs. Relying on joysticks or smartphone apps every time you want to switch the way you want to move can prove awkward and mentally taxing, says Brokoslaw Laschowski, a robotics researcher at the University of Waterloo in Canada.
Scientists are working on automated ways to help exoskeletons recognize when to switch locomotion modes — for instance, using sensors attached to legs that can detect bioelectric signals sent from your brain to your muscles telling them to move. However, this approach comes with a number of challenges, such as how how skin conductivity can change as a person’s skin gets sweatier or dries off.
Now several research groups are experimenting with a new approach: fitting exoskeleton users with wearable cameras to provide the machines with vision data that will let them operate autonomously. Artificial intelligence (AI) software can analyze this data to recognize stairs, doors, and other features of the surrounding environment and calculate how best to respond.
Laschowski leads the ExoNet project, the first open-source database of high-resolution wearable camera images of human locomotion scenarios. It holds more than 5.6 million images of indoor and outdoor real-world walking environments. The team used this data to train deep-learning algorithms; their convolutional neural networks can already automatically recognize different walking environments with 73 percent accuracy “despite the large variance in different surfaces and objects sensed by the wearable camera,” Laschowski notes.
According to Laschowski, a potential limitation of their work their reliance on conventional 2-D images, whereas depth cameras could also capture potentially useful distance data. He and his collaborators ultimately chose not to rely on depth cameras for a number of reasons, including the fact that the accuracy of depth measurements typically degrades in outdoor lighting and with increasing distance, he says.
In similar work, researchers in North Carolina had volunteers with cameras either mounted on their eyeglasses or strapped onto their knees walk through a variety of indoor and outdoor settings to capture the kind of image data exoskeletons might use to see the world around them. The aim? “To automate motion,” says Edgar Lobaton an electrical engineering researcher at North Carolina State University. He says they are focusing on how AI software might reduce uncertainty due to factors such as motion blur or overexposed images “to ensure safe operation. We want to ensure that we can really rely on the vision and AI portion before integrating it into the hardware.”
In the future, Laschowski and his colleagues will focus on improving the accuracy of their environmental analysis software with low computational and memory storage requirements, which are important for onboard, real-time operations on robotic exoskeletons. Lobaton and his team also seek to account for uncertainty introduced into their visual systems by movements .
Ultimately, the ExoNet researchers want to explore how AI software can transmit commands to exoskeletons so they can perform tasks such as climbing stairs or avoiding obstacles based on a system’s analysis of a user's current movements and the upcoming terrain. With autonomous cars as inspiration, they are seeking to develop autonomous exoskeletons that can handle the walking task without human input, Laschowski says.
However, Laschowski adds, “User safety is of the utmost importance, especially considering that we're working with individuals with mobility impairments,” resulting perhaps from advanced age or physical disabilities.
“The exoskeleton user will always have the ability to override the system should the classification algorithm or controller make a wrong decision.” Continue reading
#439077 How Scientists Grew Human Muscles in Pig ...
The little pigs bouncing around the lab looked exceedingly normal. Yet their adorable exterior hid a remarkable secret: each piglet carried two different sets of genes. For now, both sets came from their own species. But one day, one of those sets may be human.
The piglets are chimeras—creatures with intermingled sets of genes, as if multiple entities were seamlessly mashed together. Named after the Greek lion-goat-serpent monsters, chimeras may hold the key to an endless supply of human organs and tissues for transplant. The crux is growing these human parts in another animal—one close enough in size and function to our own.
Last week, a team from the University of Minnesota unveiled two mind-bending chimeras. One was joyous little piglets, each propelled by muscles grown from a different pig. Another was pig embryos, transplanted into surrogate pigs, that developed human muscles for more than 20 days.
The study, led by Drs. Mary and Daniel Garry at the University of Minnesota, had a therapeutic point: engineering a brilliant way to replace muscle loss, especially for the muscles around our skeletons that allow us to move and navigate the world. Trauma and injury, such as from firearm wounds or car crashes, can damage muscle tissue beyond the point of repair. Unfortunately, muscles are also stubborn in that donor tissue from cadavers doesn’t usually “take” at the injury site. For now, there are no effective treatments for severe muscle death, called volumetric muscle loss.
The new human-pig hybrids are designed to tackle this problem. Muscle wasting aside, the study also points to a clever “hack” that increases the amount of human tissue inside a growing pig embryo.
If further improved, the technology could “provide an unlimited supply of organs for transplantation,” said Dr. Mary Garry to Inverse. What’s more, because the human tissue can be sourced from patients themselves, the risk of rejection by the immune system is relatively low—even when grown inside a pig.
“The shortage of organs for heart transplantation, vascular grafting, and skeletal muscle is staggering,” said Garry. Human-animal chimeras could have a “seismic impact” that transforms organ transplantation and helps solve the organ shortage crisis.
That is, if society accepts the idea of a semi-humanoid pig.
Wait…But How?
The new study took a page from previous chimera recipes.
The main ingredients and steps go like this: first, you need an embryo that lacks the ability to develop a tissue or organ. This leaves an “empty slot” of sorts that you can fill with another set of genes—pig, human, or even monkey.
Second, you need to fine-tune the recipe so that the embryos “take” the new genes, incorporating them into their bodies as if they were their own. Third, the new genes activate to instruct the growing embryo to make the necessary tissue or organs without harming the overall animal. Finally, the foreign genes need to stay put, without cells migrating to another body part—say, the brain.
Not exactly straightforward, eh? The piglets are technological wonders that mix cutting-edge gene editing with cloning technologies.
The team went for two chimeras: one with two sets of pig genes, the other with a pig and human mix. Both started with a pig embryo that can’t make its own skeletal muscles (those are the muscles surrounding your bones). Using CRISPR, the gene-editing Swiss Army Knife, they snipped out three genes that are absolutely necessary for those muscles to develop. Like hitting a bullseye with three arrows simultaneously, it’s already a technological feat.
Here’s the really clever part: the muscles around your bones have a slightly different genetic makeup than the ones that line your blood vessels or the ones that pump your heart. While the resulting pig embryos had severe muscle deformities as they developed, their hearts beat as normal. This means the gene editing cut only impacted skeletal muscles.
Then came step two: replacing the missing genes. Using a microneedle, the team injected a fertilized and slightly developed pig egg—called a blastomere—into the embryo. If left on its natural course, a blastomere eventually develops into another embryo. This step “smashes” the two sets of genes together, with the newcomer filling the muscle void. The hybrid embryo was then placed into a surrogate, and roughly four months later, chimeric piglets were born.
Equipped with foreign DNA, the little guys nevertheless seemed totally normal, nosing around the lab and running everywhere without obvious clumsy stumbles. Under the microscope, their “xenomorph” muscles were indistinguishable from run-of-the-mill average muscle tissue—no signs of damage or inflammation, and as stretchy and tough as muscles usually are. What’s more, the foreign DNA seemed to have only developed into muscles, even though they were prevalent across the body. Extensive fishing experiments found no trace of the injected set of genes inside blood vessels or the brain.
A Better Human-Pig Hybrid
Confident in their recipe, the team next repeated the experiment with human cells, with a twist. Instead of using controversial human embryonic stem cells, which are obtained from aborted fetuses, they relied on induced pluripotent stem cells (iPSCs). These are skin cells that have been reverted back into a stem cell state.
Unlike previous attempts at making human chimeras, the team then scoured the genetic landscape of how pig and human embryos develop to find any genetic “brakes” that could derail the process. One gene, TP53, stood out, which was then promptly eliminated with CRISPR.
This approach provides a way for future studies to similarly increase the efficiency of interspecies chimeras, the team said.
The human-pig embryos were then carefully grown inside surrogate pigs for less than a month, and extensively analyzed. By day 20, the hybrids had already grown detectable human skeletal muscle. Similar to the pig-pig chimeras, the team didn’t detect any signs that the human genes had sprouted cells that would eventually become neurons or other non-muscle cells.
For now, human-animal chimeras are not allowed to grow to term, in part to stem the theoretical possibility of engineering humanoid hybrid animals (shudder). However, a sentient human-pig chimera is something that the team specifically addressed. Through multiple experiments, they found no trace of human genes in the embryos’ brain stem cells 20 and 27 days into development. Similarly, human donor genes were absent in cells that would become the hybrid embryos’ reproductive cells.
Despite bioethical quandaries and legal restrictions, human-animal chimeras have taken off, both as a source of insight into human brain development and a well of personalized organs and tissues for transplant. In 2019, Japan lifted its ban on developing human brain cells inside animal embryos, as well as the term limit—to global controversy. There’s also the question of animal welfare, given that hybrid clones will essentially become involuntary organ donors.
As the debates rage on, scientists are nevertheless pushing the limits of human-animal chimeras, while treading as carefully as possible.
“Our data…support the feasibility of the generation of these interspecies chimeras, which will serve as a model for translational research or, one day, as a source for xenotransplantation,” the team said.
Image Credit: Christopher Carson on Unsplash Continue reading
#438982 Quantum Computing and Reinforcement ...
Deep reinforcement learning is having a superstar moment.
Powering smarter robots. Simulating human neural networks. Trouncing physicians at medical diagnoses and crushing humanity’s best gamers at Go and Atari. While far from achieving the flexible, quick thinking that comes naturally to humans, this powerful machine learning idea seems unstoppable as a harbinger of better thinking machines.
Except there’s a massive roadblock: they take forever to run. Because the concept behind these algorithms is based on trial and error, a reinforcement learning AI “agent” only learns after being rewarded for its correct decisions. For complex problems, the time it takes an AI agent to try and fail to learn a solution can quickly become untenable.
But what if you could try multiple solutions at once?
This week, an international collaboration led by Dr. Philip Walther at the University of Vienna took the “classic” concept of reinforcement learning and gave it a quantum spin. They designed a hybrid AI that relies on both quantum and run-of-the-mill classic computing, and showed that—thanks to quantum quirkiness—it could simultaneously screen a handful of different ways to solve a problem.
The result is a reinforcement learning AI that learned over 60 percent faster than its non-quantum-enabled peers. This is one of the first tests that shows adding quantum computing can speed up the actual learning process of an AI agent, the authors explained.
Although only challenged with a “toy problem” in the study, the hybrid AI, once scaled, could impact real-world problems such as building an efficient quantum internet. The setup “could readily be integrated within future large-scale quantum communication networks,” the authors wrote.
The Bottleneck
Learning from trial and error comes intuitively to our brains.
Say you’re trying to navigate a new convoluted campground without a map. The goal is to get from the communal bathroom back to your campsite. Dead ends and confusing loops abound. We tackle the problem by deciding to turn either left or right at every branch in the road. One will get us closer to the goal; the other leads to a half hour of walking in circles. Eventually, our brain chemistry rewards correct decisions, so we gradually learn the correct route. (If you’re wondering…yeah, true story.)
Reinforcement learning AI agents operate in a similar trial-and-error way. As a problem becomes more complex, the number—and time—of each trial also skyrockets.
“Even in a moderately realistic environment, it may simply take too long to rationally respond to a given situation,” explained study author Dr. Hans Briegel at the Universität Innsbruck in Austria, who previously led efforts to speed up AI decision-making using quantum mechanics. If there’s pressure that allows “only a certain time for a response, an agent may then be unable to cope with the situation and to learn at all,” he wrote.
Many attempts have tried speeding up reinforcement learning. Giving the AI agent a short-term “memory.” Tapping into neuromorphic computing, which better resembles the brain. In 2014, Briegel and colleagues showed that a “quantum brain” of sorts can help propel an AI agent’s decision-making process after learning. But speeding up the learning process itself has eluded our best attempts.
The Hybrid AI
The new study went straight for that previously untenable jugular.
The team’s key insight was to tap into the best of both worlds—quantum and classical computing. Rather than building an entire reinforcement learning system using quantum mechanics, they turned to a hybrid approach that could prove to be more practical. Here, the AI agent uses quantum weirdness as it’s trying out new approaches—the “trial” in trial and error. The system then passes the baton to a classical computer to give the AI its reward—or not—based on its performance.
At the heart of the quantum “trial” process is a quirk called superposition. Stay with me. Our computers are powered by electrons, which can represent only two states—0 or 1. Quantum mechanics is far weirder, in that photons (particles of light) can simultaneously be both 0 and 1, with a slightly different probability of “leaning towards” one or the other.
This noncommittal oddity is part of what makes quantum computing so powerful. Take our reinforcement learning example of navigating a new campsite. In our classic world, we—and our AI—need to decide between turning left or right at an intersection. In a quantum setup, however, the AI can (in a sense) turn left and right at the same time. So when searching for the correct path back to home base, the quantum system has a leg up in that it can simultaneously explore multiple routes, making it far faster than conventional, consecutive trail and error.
“As a consequence, an agent that can explore its environment in superposition will learn significantly faster than its classical counterpart,” said Briegel.
It’s not all theory. To test out their idea, the team turned to a programmable chip called a nanophotonic processor. Think of it as a CPU-like computer chip, but it processes particles of light—photons—rather than electricity. These light-powered chips have been a long time in the making. Back in 2017, for example, a team from MIT built a fully optical neural network into an optical chip to bolster deep learning.
The chips aren’t all that exotic. Nanophotonic processors act kind of like our eyeglasses, which can carry out complex calculations that transform light that passes through them. In the glasses case, they let people see better. For a light-based computer chip, it allows computation. Rather than using electrical cables, the chips use “wave guides” to shuttle photons and perform calculations based on their interactions.
The “error” or “reward” part of the new hardware comes from a classical computer. The nanophotonic processor is coupled to a traditional computer, where the latter provides the quantum circuit with feedback—that is, whether to reward a solution or not. This setup, the team explains, allows them to more objectively judge any speed-ups in learning in real time.
In this way, a hybrid reinforcement learning agent alternates between quantum and classical computing, trying out ideas in wibbly-wobbly “multiverse” land while obtaining feedback in grounded, classic physics “normality.”
A Quantum Boost
In simulations using 10,000 AI agents and actual experimental data from 165 trials, the hybrid approach, when challenged with a more complex problem, showed a clear leg up.
The key word is “complex.” The team found that if an AI agent has a high chance of figuring out the solution anyway—as for a simple problem—then classical computing works pretty well. The quantum advantage blossoms when the task becomes more complex or difficult, allowing quantum mechanics to fully flex its superposition muscles. For these problems, the hybrid AI was 63 percent faster at learning a solution compared to traditional reinforcement learning, decreasing its learning effort from 270 guesses to 100.
Now that scientists have shown a quantum boost for reinforcement learning speeds, the race for next-generation computing is even more lit. Photonics hardware required for long-range light-based communications is rapidly shrinking, while improving signal quality. The partial-quantum setup could “aid specifically in problems where frequent search is needed, for example, network routing problems” that’s prevalent for a smooth-running internet, the authors wrote. With a quantum boost, reinforcement learning may be able to tackle far more complex problems—those in the real world—than currently possible.
“We are just at the beginning of understanding the possibilities of quantum artificial intelligence,” said lead author Walther.
Image Credit: Oleg Gamulinskiy from Pixabay Continue reading
#438720 Credit card-sized soft pumps power ...
Robotic clothing that is entirely soft and could help people to move more easily is a step closer to reality thanks to the development of a new flexible and lightweight power system for soft robotics. Continue reading