Tag Archives: mind
#439077 How Scientists Grew Human Muscles in Pig ...
The little pigs bouncing around the lab looked exceedingly normal. Yet their adorable exterior hid a remarkable secret: each piglet carried two different sets of genes. For now, both sets came from their own species. But one day, one of those sets may be human.
The piglets are chimeras—creatures with intermingled sets of genes, as if multiple entities were seamlessly mashed together. Named after the Greek lion-goat-serpent monsters, chimeras may hold the key to an endless supply of human organs and tissues for transplant. The crux is growing these human parts in another animal—one close enough in size and function to our own.
Last week, a team from the University of Minnesota unveiled two mind-bending chimeras. One was joyous little piglets, each propelled by muscles grown from a different pig. Another was pig embryos, transplanted into surrogate pigs, that developed human muscles for more than 20 days.
The study, led by Drs. Mary and Daniel Garry at the University of Minnesota, had a therapeutic point: engineering a brilliant way to replace muscle loss, especially for the muscles around our skeletons that allow us to move and navigate the world. Trauma and injury, such as from firearm wounds or car crashes, can damage muscle tissue beyond the point of repair. Unfortunately, muscles are also stubborn in that donor tissue from cadavers doesn’t usually “take” at the injury site. For now, there are no effective treatments for severe muscle death, called volumetric muscle loss.
The new human-pig hybrids are designed to tackle this problem. Muscle wasting aside, the study also points to a clever “hack” that increases the amount of human tissue inside a growing pig embryo.
If further improved, the technology could “provide an unlimited supply of organs for transplantation,” said Dr. Mary Garry to Inverse. What’s more, because the human tissue can be sourced from patients themselves, the risk of rejection by the immune system is relatively low—even when grown inside a pig.
“The shortage of organs for heart transplantation, vascular grafting, and skeletal muscle is staggering,” said Garry. Human-animal chimeras could have a “seismic impact” that transforms organ transplantation and helps solve the organ shortage crisis.
That is, if society accepts the idea of a semi-humanoid pig.
Wait…But How?
The new study took a page from previous chimera recipes.
The main ingredients and steps go like this: first, you need an embryo that lacks the ability to develop a tissue or organ. This leaves an “empty slot” of sorts that you can fill with another set of genes—pig, human, or even monkey.
Second, you need to fine-tune the recipe so that the embryos “take” the new genes, incorporating them into their bodies as if they were their own. Third, the new genes activate to instruct the growing embryo to make the necessary tissue or organs without harming the overall animal. Finally, the foreign genes need to stay put, without cells migrating to another body part—say, the brain.
Not exactly straightforward, eh? The piglets are technological wonders that mix cutting-edge gene editing with cloning technologies.
The team went for two chimeras: one with two sets of pig genes, the other with a pig and human mix. Both started with a pig embryo that can’t make its own skeletal muscles (those are the muscles surrounding your bones). Using CRISPR, the gene-editing Swiss Army Knife, they snipped out three genes that are absolutely necessary for those muscles to develop. Like hitting a bullseye with three arrows simultaneously, it’s already a technological feat.
Here’s the really clever part: the muscles around your bones have a slightly different genetic makeup than the ones that line your blood vessels or the ones that pump your heart. While the resulting pig embryos had severe muscle deformities as they developed, their hearts beat as normal. This means the gene editing cut only impacted skeletal muscles.
Then came step two: replacing the missing genes. Using a microneedle, the team injected a fertilized and slightly developed pig egg—called a blastomere—into the embryo. If left on its natural course, a blastomere eventually develops into another embryo. This step “smashes” the two sets of genes together, with the newcomer filling the muscle void. The hybrid embryo was then placed into a surrogate, and roughly four months later, chimeric piglets were born.
Equipped with foreign DNA, the little guys nevertheless seemed totally normal, nosing around the lab and running everywhere without obvious clumsy stumbles. Under the microscope, their “xenomorph” muscles were indistinguishable from run-of-the-mill average muscle tissue—no signs of damage or inflammation, and as stretchy and tough as muscles usually are. What’s more, the foreign DNA seemed to have only developed into muscles, even though they were prevalent across the body. Extensive fishing experiments found no trace of the injected set of genes inside blood vessels or the brain.
A Better Human-Pig Hybrid
Confident in their recipe, the team next repeated the experiment with human cells, with a twist. Instead of using controversial human embryonic stem cells, which are obtained from aborted fetuses, they relied on induced pluripotent stem cells (iPSCs). These are skin cells that have been reverted back into a stem cell state.
Unlike previous attempts at making human chimeras, the team then scoured the genetic landscape of how pig and human embryos develop to find any genetic “brakes” that could derail the process. One gene, TP53, stood out, which was then promptly eliminated with CRISPR.
This approach provides a way for future studies to similarly increase the efficiency of interspecies chimeras, the team said.
The human-pig embryos were then carefully grown inside surrogate pigs for less than a month, and extensively analyzed. By day 20, the hybrids had already grown detectable human skeletal muscle. Similar to the pig-pig chimeras, the team didn’t detect any signs that the human genes had sprouted cells that would eventually become neurons or other non-muscle cells.
For now, human-animal chimeras are not allowed to grow to term, in part to stem the theoretical possibility of engineering humanoid hybrid animals (shudder). However, a sentient human-pig chimera is something that the team specifically addressed. Through multiple experiments, they found no trace of human genes in the embryos’ brain stem cells 20 and 27 days into development. Similarly, human donor genes were absent in cells that would become the hybrid embryos’ reproductive cells.
Despite bioethical quandaries and legal restrictions, human-animal chimeras have taken off, both as a source of insight into human brain development and a well of personalized organs and tissues for transplant. In 2019, Japan lifted its ban on developing human brain cells inside animal embryos, as well as the term limit—to global controversy. There’s also the question of animal welfare, given that hybrid clones will essentially become involuntary organ donors.
As the debates rage on, scientists are nevertheless pushing the limits of human-animal chimeras, while treading as carefully as possible.
“Our data…support the feasibility of the generation of these interspecies chimeras, which will serve as a model for translational research or, one day, as a source for xenotransplantation,” the team said.
Image Credit: Christopher Carson on Unsplash Continue reading
Posted in Human Robots
#439042 How Scientists Used Ultrasound to Read ...
Thanks to neural implants, mind reading is no longer science fiction.
As I’m writing this sentence, a tiny chip with arrays of electrodes could sit on my brain, listening in on the crackling of my neurons firing as my hands dance across the keyboard. Sophisticated algorithms could then decode these electrical signals in real time. My brain’s inner language to plan and move my fingers could then be used to guide a robotic hand to do the same. Mind-to-machine control, voilà!
Yet as the name implies, even the most advanced neural implant has a problem: it’s an implant. For electrodes to reliably read the brain’s electrical chatter, they need to pierce through the its protective membrane and into brain tissue. Danger of infection aside, over time, damage accumulates around the electrodes, distorting their signals or even rendering them unusable.
Now, researchers from Caltech have paved a way to read the brain without any physical contact. Key to their device is a relatively new superstar in neuroscience: functional ultrasound, which uses sound waves to capture activity in the brain.
In monkeys, the technology could reliably predict their eye movement and hand gestures after just a single trial—without the usual lengthy training process needed to decode a movement. If adopted by humans, the new mind-reading tech represents a triple triumph: it requires minimal surgery and minimal learning, but yields maximal resolution for brain decoding. For people who are paralyzed, it could be a paradigm shift in how they control their prosthetics.
“We pushed the limits of ultrasound neuroimaging and were thrilled that it could predict movement,” said study author Dr. Sumner Norman.
To Dr. Krishna Shenoy at Stanford, who was not involved, the study will finally put ultrasound “on the map as a brain-machine interface technique. Adding to this toolkit is spectacular,” he said.
Breaking the Sound Barrier
Using sound to decode brain activity might seem preposterous, but ultrasound has had quite the run in medicine. You’ve probably heard of its most common use: taking photos of a fetus in pregnancy. The technique uses a transducer, which emits ultrasound pulses into the body and finds boundaries in tissue structure by analyzing the sound waves that bounce back.
Roughly a decade ago, neuroscientists realized they could adapt the tech for brain scanning. Rather than directly measuring the brain’s electrical chatter, it looks at a proxy—blood flow. When certain brain regions or circuits are active, the brain requires much more energy, which is provided by increased blood flow. In this way, functional ultrasound works similarly to functional MRI, but at a far higher resolution—roughly ten times, the authors said. Plus, people don’t have to lie very still in an expensive, claustrophobic magnet.
“A key question in this work was: If we have a technique like functional ultrasound that gives us high-resolution images of the brain’s blood flow dynamics in space and over time, is there enough information from that imaging to decode something useful about behavior?” said study author Dr. Mikhail Shapiro.
There’s plenty of reasons for doubt. As the new kid on the block, functional ultrasound has some known drawbacks. A major one: it gives a far less direct signal than electrodes. Previous studies show that, with multiple measurements, it can provide a rough picture of brain activity. But is that enough detail to guide a robotic prosthesis?
One-Trial Wonder
The new study put functional ultrasound to the ultimate test: could it reliably detect movement intention in monkeys? Because their brains are the most similar to ours, rhesus macaque monkeys are often the critical step before a brain-machine interface technology is adapted for humans.
The team first inserted small ultrasound transducers into the skulls of two rhesus monkeys. While it sounds intense, the surgery doesn’t penetrate the brain or its protective membrane; it’s only on the skull. Compared to electrodes, this means the brain itself isn’t physically harmed.
The device is linked to a computer, which controls the direction of sound waves and captures signals from the brain. For this study, the team aimed the pulses at the posterior parietal cortex, a part of the “motor” aspect of the brain, which plans movement. If right now you’re thinking about scrolling down this page, that’s the brain region already activated, before your fingers actually perform the movement.
Then came the tests. The first looked at eye movements—something pretty necessary before planning actual body movements without tripping all over the place. Here, the monkeys learned to focus on a central dot on a computer screen. A second dot, either left or right, then flashed. The monkeys’ task was to flicker their eyes to the most recent dot. It’s something that seems easy for us, but requires sophisticated brain computation.
The second task was more straightforward. Rather than just moving their eyes to the second target dot, the monkeys learned to grab and manipulate a joystick to move a cursor to that target.
Using brain imaging to decode the mind and control movement. Image Credit: S. Norman, Caltech
As the monkeys learned, so did the device. Ultrasound data capturing brain activity was fed into a sophisticated machine learning algorithm to guess the monkeys’ intentions. Here’s the kicker: once trained, using data from just a single trial, the algorithm was able to correctly predict the monkeys’ actual eye movement—whether left or right—with roughly 78 percent accuracy. The accuracy for correctly maneuvering the joystick was even higher, at nearly 90 percent.
That’s crazy accurate, and very much needed for a mind-controlled prosthetic. If you’re using a mind-controlled cursor or limb, the last thing you’d want is to have to imagine the movement multiple times before you actually click the web button, grab the door handle, or move your robotic leg.
Even more impressive is the resolution. Sound waves seem omnipresent, but with focused ultrasound, it’s possible to measure brain activity at a resolution of 100 microns—roughly 10 neurons in the brain.
A Cyborg Future?
Before you start worrying about scientists blasting your brain with sound waves to hack your mind, don’t worry. The new tech still requires skull surgery, meaning that a small chunk of skull needs to be removed. However, the brain itself is spared. This means that compared to electrodes, ultrasound could offer less damage and potentially a far longer mind reading than anything currently possible.
There are downsides. Focused ultrasound is far younger than any electrode-based neural implants, and can’t yet reliably decode 360-degree movement or fine finger movements. For now, the tech requires a wire to link the device to a computer, which is off-putting to many people and will prevent widespread adoption. Add to that the inherent downside of focused ultrasound, which lags behind electrical recordings by roughly two seconds.
All that aside, however, the tech is just tiptoeing into a future where minds and machines seamlessly connect. Ultrasound can penetrate the skull, though not yet at the resolution needed for imaging and decoding brain activity. The team is already working with human volunteers with traumatic brain injuries, who had to have a piece of their skulls removed, to see how well ultrasound works for reading their minds.
“What’s most exciting is that functional ultrasound is a young technique with huge potential. This is just our first step in bringing high performance, less invasive brain-machine interface to more people,” said Norman.
Image Credit: Free-Photos / Pixabay Continue reading
Posted in Human Robots
#439023 In ‘Klara and the Sun,’ We Glimpse ...
In a store in the center of an unnamed city, humanoid robots are displayed alongside housewares and magazines. They watch the fast-moving world outside the window, anxiously awaiting the arrival of customers who might buy them and take them home. Among them is Klara, a particularly astute robot who loves the sun and wants to learn as much as possible about humans and the world they live in.
So begins Kazuo Ishiguro’s new novel Klara and the Sun, published earlier this month. The book, told from Klara’s perspective, portrays an eerie future society in which intelligent machines and other advanced technologies have been integrated into daily life, but not everyone is happy about it.
Technological unemployment, the progress of artificial intelligence, inequality, the safety and ethics of gene editing, increasing loneliness and isolation—all of which we’re grappling with today—show up in Ishiguro’s world. It’s like he hit a fast-forward button, mirroring back to us how things might play out if we don’t approach these technologies with caution and foresight.
The wealthy genetically edit or “lift” their children to set them up for success, while the poor have to make do with the regular old brains and bodies bequeathed them by evolution. Lifted and unlifted kids generally don’t mix, and this is just one of many sinister delineations between a new breed of haves and have-nots.
There’s anger about robots’ steady infiltration into everyday life, and questions about how similar their rights should be to those of humans. “First they take the jobs. Then they take the seats at the theater?” one woman fumes.
References to “changes” and “substitutions” allude to an economy where automation has eliminated millions of jobs. While “post-employed” people squat in abandoned buildings and fringe communities arm themselves in preparation for conflict, those whose livelihoods haven’t been destroyed can afford to have live-in housekeepers and buy Artificial Friends (or AFs) for their lonely children.
“The old traditional model that we still live with now—where most of us can get some kind of paid work in exchange for our services or the goods we make—has broken down,” Ishiguro said in a podcast discussion of the novel. “We’re not talking just about the difference between rich and poor getting bigger. We’re talking about a gap appearing between people who participate in society in an obvious way and people who do not.”
He has a point; as much as techno-optimists claim that the economic changes brought by automation and AI will give us all more free time, let us work less, and devote time to our passion projects, how would that actually play out? What would millions of “post-employed” people receiving basic income actually do with their time and energy?
In the novel, we don’t get much of a glimpse of this side of the equation, but we do see how the wealthy live. After a long wait, just as the store manager seems ready to give up on selling her, Klara is chosen by a 14-year-old girl named Josie, the daughter of a woman who wears “high-rank clothes” and lives in a large, sunny home outside the city. Cheerful and kind, Josie suffers from an unspecified illness that periodically flares up and leaves her confined to her bed for days at a time.
Her life seems somewhat bleak, the need for an AF clear. In this future world, the children of the wealthy no longer go to school together, instead studying alone at home on their digital devices. “Interaction meetings” are set up for them to learn to socialize, their parents carefully eavesdropping from the next room and trying not to intervene when there’s conflict or hurt feelings.
Klara does her best to be a friend, aide, and confidante to Josie while continuing to learn about the world around her and decode the mysteries of human behavior. We surmise that she was programmed with a basic ability to understand emotions, which evolves along with her other types of intelligence. “I believe I have many feelings. The more I observe, the more feelings become available to me,” she explains to one character.
Ishiguro does an excellent job of representing Klara’s mind: a blend of pre-determined programming, observation, and continuous learning. Her narration has qualities both robotic and human; we can tell when something has been programmed in—she “Gives Privacy” to the humans around her when that’s appropriate, for example—and when she’s figured something out for herself.
But the author maintains some mystery around Klara’s inner emotional life. “Does she actually understand human emotions, or is she just observing human emotions and simulating them within herself?” he said. “I suppose the question comes back to, what are our emotions as human beings? What do they amount to?”
Klara is particularly attuned to human loneliness, since she essentially was made to help prevent it. It is, in her view, peoples’ biggest fear, and something they’ll go to great lengths to avoid, yet can never fully escape. “Perhaps all humans are lonely,” she says.
Warding off loneliness through technology isn’t a futuristic idea, it’s something we’ve been doing for a long time, with the technologies at hand growing more and more sophisticated. Products like AFs already exist. There’s XiaoIce, a chatbot that uses “sentiment analysis” to keep its 660 million users engaged, and Azuma Hikari, a character-based AI designed to “bring comfort” to users whose lives lack emotional connection with other humans.
The mere existence of these tools would be sinister if it wasn’t for their widespread adoption; when millions of people use AIs to fill a void in their lives, it raises deeper questions about our ability to connect with each other and whether technology is building it up or tearing it down.
This isn’t the only big question the novel tackles. An overarching theme is one we’ve been increasingly contemplating as computers start to acquire more complex capabilities, like the beginnings of creativity or emotional awareness: What is it that truly makes us human?
“Do you believe in the human heart?” one character asks. “I don’t mean simply the organ, obviously. I’m speaking in the poetic sense. The human heart. Do you think there is such a thing? Something that makes each of us special and individual?”
The alternative, at least in the story, is that people don’t have a unique essence, but rather we’re all a blend of traits and personalities that can be reduced to strings of code. Our understanding of the brain is still elementary, but at some level, doesn’t all human experience boil down to the firing of billions of neurons between our ears? Will we one day—in a future beyond that painted by Ishiguro, but certainly foreshadowed by it—be able to “decode” our humanity to the point that there’s nothing mysterious left about it? “A human heart is bound to be complex,” Klara says. “But it must be limited.”
Whether or not you agree, Klara and the Sun is worth the read. It’s both a marvelous, engaging story about what it means to love and be human, and a prescient warning to approach technological change with caution and nuance. We’re already living in a world where AI keeps us company, influences our behavior, and is wreaking various forms of havoc. Ishiguro’s novel is a snapshot of one of our possible futures, told through the eyes of a robot who keeps you rooting for her to the end.
Image Credit: Marion Wellmann from Pixabay Continue reading
Posted in Human Robots
#438785 Video Friday: A Blimp For Your Cat
Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):
HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
ICRA 2021 – May 30-5, 2021 – Xi'an, China
Let us know if you have suggestions for next week, and enjoy today's videos.
Shiny robotic cat toy blimp!
I am pretty sure this is Google Translate getting things wrong, but the About page mentions that the blimp will “take you to your destination after appearing in the death of God.”
[ NTT DoCoMo ] via [ RobotStart ]
If you have yet to see this real-time video of Perseverance landing on Mars, drop everything and watch it.
During the press conference, someone commented that this is the first time anyone on the team who designed and built this system has ever seen it in operation, since it could only be tested at the component scale on Earth. This landing system has blown my mind since Curiosity.
Here's a better look at where Percy ended up:
[ NASA ]
The fact that Digit can just walk up and down wet, slippery, muddy hills without breaking a sweat is (still) astonishing.
[ Agility Robotics ]
SkyMul wants drones to take over the task of tying rebar, which looks like just the sort of thing we'd rather robots be doing so that we don't have to:
The tech certainly looks promising, and SkyMul says that they're looking for some additional support to bring things to the pilot stage.
[ SkyMul ]
Thanks Eohan!
Flatcat is a pet-like, playful robot that reacts to touch. Flatcat feels everything exactly: Cuddle with it, romp around with it, or just watch it do weird things of its own accord. We are sure that flatcat will amaze you, like us, and caress your soul.
I don't totally understand it, but I want it anyway.
[ Flatcat ]
Thanks Oswald!
This is how I would have a romantic dinner date if I couldn't get together in person. Herman the UR3 and an OptiTrack system let me remotely make a romantic meal!
[ Dave's Armoury ]
Here, we propose a novel design of deformable propellers inspired by dragonfly wings. The structure of these propellers includes a flexible segment similar to the nodus on a dragonfly wing. This flexible segment can bend, twist and even fold upon collision, absorbing force upon impact and protecting the propeller from damage.
[ Paper ]
Thanks Van!
In the 1970s, The CIA created the world's first miniaturized unmanned aerial vehicle, or UAV, which was intended to be a clandestine listening device. The Insectothopter was never deployed operationally, but was still revolutionary for its time.
It may never have been deployed (not that they'll admit to, anyway), but it was definitely operational and could fly controllably.
[ CIA ]
Research labs are starting to get Digits, which means we're going to get a much better idea of what its limitations are.
[ Ohio State ]
This video shows the latest achievements for LOLA walking on undetected uneven terrain. The robot is technically blind, not using any camera-based or prior information on the terrain.
[ TUM ]
We define “robotic contact juggling” to be the purposeful control of the motion of a three-dimensional smooth object as it rolls freely on a motion-controlled robot manipulator, or “hand.” While specific examples of robotic contact juggling have been studied before, in this paper we provide the first general formulation and solution method for the case of an arbitrary smooth object in single-point rolling contact on an arbitrary smooth hand.
[ Paper ]
Thanks Fan!
A couple of new cobots from ABB, designed to work safely around humans.
[ ABB ]
Thanks Fan!
It's worth watching at least a little bit of Adam Savage testing Spot's new arm, because we get to see Spot try, fail, and eventually succeed at an autonomous door-opening behavior at the 10 minute mark.
[ Tested ]
SVR discusses diversity with guest speakers Dr. Michelle Johnson from the GRASP Lab at UPenn; Dr Ariel Anders from Women in Robotics and first technical hire at Robust.ai; Alka Roy from The Responsible Innovation Project; and Kenechukwu C. Mbanesi and Kenya Andrews from Black in Robotics. The discussion here is moderated by Dr. Ken Goldberg—artist, roboticist and Director of the CITRIS People and Robots Lab—and Andra Keay from Silicon Valley Robotics.
[ SVR ]
RAS presents a Soft Robotics Debate on Bioinspired vs. Biohybrid Design.
In this debate, we will bring together experts in Bioinspiration and Biohybrid design to discuss the necessary steps to make more competent soft robots. We will try to answer whether bioinspired research should focus more on developing new bioinspired material and structures or on the integration of living and artificial structures in biohybrid designs.
[ RAS SoRo ]
IFRR presents a Colloquium on Human Robot Interaction.
Across many application domains, robots are expected to work in human environments, side by side with people. The users will vary substantially in background, training, physical and cognitive abilities, and readiness to adopt technology. Robotic products are expected to not only be intuitive, easy to use, and responsive to the needs and states of their users, but they must also be designed with these differences in mind, making human-robot interaction (HRI) a key area of research.
[ IFRR ]
Vijay Kumar, Nemirovsky Family Dean and Professor at Penn Engineering, gives an introduction to ENIAC day and David Patterson, Pardee Professor of Computer Science, Emeritus at the University of California at Berkeley, speaks about the legacy of the ENIAC and its impact on computer architecture today. This video is comprised of lectures one and two of nine total lectures in the ENIAC Day series.
There are more interesting ENIAC videos at the link below, but we'll highlight this particular one, about the women of the ENIAC, also known as the First Programmers.
[ ENIAC Day ] Continue reading
Posted in Human Robots