Tag Archives: machine

#432190 In the Future, There Will Be No Limit to ...

New planets found in distant corners of the galaxy. Climate models that may improve our understanding of sea level rise. The emergence of new antimalarial drugs. These scientific advances and discoveries have been in the news in recent months.

While representing wildly divergent disciplines, from astronomy to biotechnology, they all have one thing in common: Artificial intelligence played a key role in their scientific discovery.

One of the more recent and famous examples came out of NASA at the end of 2017. The US space agency had announced an eighth planet discovered in the Kepler-90 system. Scientists had trained a neural network—a computer with a “brain” modeled on the human mind—to re-examine data from Kepler, a space-borne telescope with a four-year mission to seek out new life and new civilizations. Or, more precisely, to find habitable planets where life might just exist.

The researchers trained the artificial neural network on a set of 15,000 previously vetted signals until it could identify true planets and false positives 96 percent of the time. It then went to work on weaker signals from nearly 700 star systems with known planets.

The machine detected Kepler 90i—a hot, rocky planet that orbits its sun about every two Earth weeks—through a nearly imperceptible change in brightness captured when a planet passes a star. It also found a sixth Earth-sized planet in the Kepler-80 system.

AI Handles Big Data
The application of AI to science is being driven by three great advances in technology, according to Ross King from the Manchester Institute of Biotechnology at the University of Manchester, leader of a team that developed an artificially intelligent “scientist” called Eve.

Those three advances include much faster computers, big datasets, and improved AI methods, King said. “These advances increasingly give AI superhuman reasoning abilities,” he told Singularity Hub by email.

AI systems can flawlessly remember vast numbers of facts and extract information effortlessly from millions of scientific papers, not to mention exhibit flawless logical reasoning and near-optimal probabilistic reasoning, King says.

AI systems also beat humans when it comes to dealing with huge, diverse amounts of data.

That’s partly what attracted a team of glaciologists to turn to machine learning to untangle the factors involved in how heat from Earth’s interior might influence the ice sheet that blankets Greenland.

Algorithms juggled 22 geologic variables—such as bedrock topography, crustal thickness, magnetic anomalies, rock types, and proximity to features like trenches, ridges, young rifts, and volcanoes—to predict geothermal heat flux under the ice sheet throughout Greenland.

The machine learning model, for example, predicts elevated heat flux upstream of Jakobshavn Glacier, the fastest-moving glacier in the world.

“The major advantage is that we can incorporate so many different types of data,” explains Leigh Stearns, associate professor of geology at Kansas University, whose research takes her to the polar regions to understand how and why Earth’s great ice sheets are changing, questions directly related to future sea level rise.

“All of the other models just rely on one parameter to determine heat flux, but the [machine learning] approach incorporates all of them,” Stearns told Singularity Hub in an email. “Interestingly, we found that there is not just one parameter…that determines the heat flux, but a combination of many factors.”

The research was published last month in Geophysical Research Letters.

Stearns says her team hopes to apply high-powered machine learning to characterize glacier behavior over both short and long-term timescales, thanks to the large amounts of data that she and others have collected over the last 20 years.

Emergence of Robot Scientists
While Stearns sees machine learning as another tool to augment her research, King believes artificial intelligence can play a much bigger role in scientific discoveries in the future.

“I am interested in developing AI systems that autonomously do science—robot scientists,” he said. Such systems, King explained, would automatically originate hypotheses to explain observations, devise experiments to test those hypotheses, physically run the experiments using laboratory robotics, and even interpret the results. The conclusions would then influence the next cycle of hypotheses and experiments.

His AI scientist Eve recently helped researchers discover that triclosan, an ingredient commonly found in toothpaste, could be used as an antimalarial drug against certain strains that have developed a resistance to other common drug therapies. The research was published in the journal Scientific Reports.

Automation using artificial intelligence for drug discovery has become a growing area of research, as the machines can work orders of magnitude faster than any human. AI is also being applied in related areas, such as synthetic biology for the rapid design and manufacture of microorganisms for industrial uses.

King argues that machines are better suited to unravel the complexities of biological systems, with even the most “simple” organisms are host to thousands of genes, proteins, and small molecules that interact in complicated ways.

“Robot scientists and semi-automated AI tools are essential for the future of biology, as there are simply not enough human biologists to do the necessary work,” he said.

Creating Shockwaves in Science
The use of machine learning, neural networks, and other AI methods can often get better results in a fraction of the time it would normally take to crunch data.

For instance, scientists at the National Center for Supercomputing Applications, located at the University of Illinois at Urbana-Champaign, have a deep learning system for the rapid detection and characterization of gravitational waves. Gravitational waves are disturbances in spacetime, emanating from big, high-energy cosmic events, such as the massive explosion of a star known as a supernova. The “Holy Grail” of this type of research is to detect gravitational waves from the Big Bang.

Dubbed Deep Filtering, the method allows real-time processing of data from LIGO, a gravitational wave observatory comprised of two enormous laser interferometers located thousands of miles apart in California and Louisiana. The research was published in Physics Letters B. You can watch a trippy visualization of the results below.

In a more down-to-earth example, scientists published a paper last month in Science Advances on the development of a neural network called ConvNetQuake to detect and locate minor earthquakes from ground motion measurements called seismograms.

ConvNetQuake uncovered 17 times more earthquakes than traditional methods. Scientists say the new method is particularly useful in monitoring small-scale seismic activity, which has become more frequent, possibly due to fracking activities that involve injecting wastewater deep underground. You can learn more about ConvNetQuake in this video:

King says he believes that in the long term there will be no limit to what AI can accomplish in science. He and his team, including Eve, are currently working on developing cancer therapies under a grant from DARPA.

“Robot scientists are getting smarter and smarter; human scientists are not,” he says. “Indeed, there is arguably a case that human scientists are less good. I don’t see any scientist alive today of the stature of a Newton or Einstein—despite the vast number of living scientists. The Physics Nobel [laureate] Frank Wilczek is on record as saying (10 years ago) that in 100 years’ time the best physicist will be a machine. I agree.”

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#432181 Putting AI in Your Pocket: MIT Chip Cuts ...

Neural networks are powerful things, but they need a lot of juice. Engineers at MIT have now developed a new chip that cuts neural nets’ power consumption by up to 95 percent, potentially allowing them to run on battery-powered mobile devices.

Smartphones these days are getting truly smart, with ever more AI-powered services like digital assistants and real-time translation. But typically the neural nets crunching the data for these services are in the cloud, with data from smartphones ferried back and forth.

That’s not ideal, as it requires a lot of communication bandwidth and means potentially sensitive data is being transmitted and stored on servers outside the user’s control. But the huge amounts of energy needed to power the GPUs neural networks run on make it impractical to implement them in devices that run on limited battery power.

Engineers at MIT have now designed a chip that cuts that power consumption by up to 95 percent by dramatically reducing the need to shuttle data back and forth between a chip’s memory and processors.

Neural nets consist of thousands of interconnected artificial neurons arranged in layers. Each neuron receives input from multiple neurons in the layer below it, and if the combined input passes a certain threshold it then transmits an output to multiple neurons above it. The strength of the connection between neurons is governed by a weight, which is set during training.

This means that for every neuron, the chip has to retrieve the input data for a particular connection and the connection weight from memory, multiply them, store the result, and then repeat the process for every input. That requires a lot of data to be moved around, expending a lot of energy.

The new MIT chip does away with that, instead computing all the inputs in parallel within the memory using analog circuits. That significantly reduces the amount of data that needs to be shoved around and results in major energy savings.

The approach requires the weights of the connections to be binary rather than a range of values, but previous theoretical work had suggested this wouldn’t dramatically impact accuracy, and the researchers found the chip’s results were generally within two to three percent of the conventional non-binary neural net running on a standard computer.

This isn’t the first time researchers have created chips that carry out processing in memory to reduce the power consumption of neural nets, but it’s the first time the approach has been used to run powerful convolutional neural networks popular for image-based AI applications.

“The results show impressive specifications for the energy-efficient implementation of convolution operations with memory arrays,” Dario Gil, vice president of artificial intelligence at IBM, said in a statement.

“It certainly will open the possibility to employ more complex convolutional neural networks for image and video classifications in IoT [the internet of things] in the future.”

It’s not just research groups working on this, though. The desire to get AI smarts into devices like smartphones, household appliances, and all kinds of IoT devices is driving the who’s who of Silicon Valley to pile into low-power AI chips.

Apple has already integrated its Neural Engine into the iPhone X to power things like its facial recognition technology, and Amazon is rumored to be developing its own custom AI chips for the next generation of its Echo digital assistant.

The big chip companies are also increasingly pivoting towards supporting advanced capabilities like machine learning, which has forced them to make their devices ever more energy-efficient. Earlier this year ARM unveiled two new chips: the Arm Machine Learning processor, aimed at general AI tasks from translation to facial recognition, and the Arm Object Detection processor for detecting things like faces in images.

Qualcomm’s latest mobile chip, the Snapdragon 845, features a GPU and is heavily focused on AI. The company has also released the Snapdragon 820E, which is aimed at drones, robots, and industrial devices.

Going a step further, IBM and Intel are developing neuromorphic chips whose architectures are inspired by the human brain and its incredible energy efficiency. That could theoretically allow IBM’s TrueNorth and Intel’s Loihi to run powerful machine learning on a fraction of the power of conventional chips, though they are both still highly experimental at this stage.

Getting these chips to run neural nets as powerful as those found in cloud services without burning through batteries too quickly will be a big challenge. But at the current pace of innovation, it doesn’t look like it will be too long before you’ll be packing some serious AI power in your pocket.

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#432051 What Roboticists Are Learning From Early ...

You might not have heard of Hanson Robotics, but if you’re reading this, you’ve probably seen their work. They were the company behind Sophia, the lifelike humanoid avatar that’s made dozens of high-profile media appearances. Before that, they were the company behind that strange-looking robot that seemed a bit like Asimo with Albert Einstein’s head—or maybe you saw BINA48, who was interviewed for the New York Times in 2010 and featured in Jon Ronson’s books. For the sci-fi aficionados amongst you, they even made a replica of legendary author Philip K. Dick, best remembered for having books with titles like Do Androids Dream of Electric Sheep? turned into films with titles like Blade Runner.

Hanson Robotics, in other words, with their proprietary brand of life-like humanoid robots, have been playing the same game for a while. Sometimes it can be a frustrating game to watch. Anyone who gives the robot the slightest bit of thought will realize that this is essentially a chat-bot, with all the limitations this implies. Indeed, even in that New York Times interview with BINA48, author Amy Harmon describes it as a frustrating experience—with “rare (but invariably thrilling) moments of coherence.” This sensation will be familiar to anyone who’s conversed with a chatbot that has a few clever responses.

The glossy surface belies the lack of real intelligence underneath; it seems, at first glance, like a much more advanced machine than it is. Peeling back that surface layer—at least for a Hanson robot—means you’re peeling back Frubber. This proprietary substance—short for “Flesh Rubber,” which is slightly nightmarish—is surprisingly complicated. Up to thirty motors are required just to control the face; they manipulate liquid cells in order to make the skin soft, malleable, and capable of a range of different emotional expressions.

A quick combinatorial glance at the 30+ motors suggests that there are millions of possible combinations; researchers identify 62 that they consider “human-like” in Sophia, although not everyone agrees with this assessment. Arguably, the technical expertise that went into reconstructing the range of human facial expressions far exceeds the more simplistic chat engine the robots use, although it’s the second one that allows it to inflate the punters’ expectations with a few pre-programmed questions in an interview.

Hanson Robotics’ belief is that, ultimately, a lot of how humans will eventually relate to robots is going to depend on their faces and voices, as well as on what they’re saying. “The perception of identity is so intimately bound up with the perception of the human form,” says David Hanson, company founder.

Yet anyone attempting to design a robot that won’t terrify people has to contend with the uncanny valley—that strange blend of concern and revulsion people react with when things appear to be creepily human. Between cartoonish humanoids and genuine humans lies what has often been a no-go zone in robotic aesthetics.

The uncanny valley concept originated with roboticist Masahiro Mori, who argued that roboticists should avoid trying to replicate humans exactly. Since anything that wasn’t perfect, but merely very good, would elicit an eerie feeling in humans, shirking the challenge entirely was the only way to avoid the uncanny valley. It’s probably a task made more difficult by endless streams of articles about AI taking over the world that inexplicably conflate AI with killer humanoid Terminators—which aren’t particularly likely to exist (although maybe it’s best not to push robots around too much).

The idea behind this realm of psychological horror is fairly simple, cognitively speaking.

We know how to categorize things that are unambiguously human or non-human. This is true even if they’re designed to interact with us. Consider the popularity of Aibo, Jibo, or even some robots that don’t try to resemble humans. Something that resembles a human, but isn’t quite right, is bound to evoke a fear response in the same way slightly distorted music or slightly rearranged furniture in your home will. The creature simply doesn’t fit.

You may well reject the idea of the uncanny valley entirely. David Hanson, naturally, is not a fan. In the paper Upending the Uncanny Valley, he argues that great art forms have often resembled humans, but the ultimate goal for humanoid roboticists is probably to create robots we can relate to as something closer to humans than works of art.

Meanwhile, Hanson and other scientists produce competing experiments to either demonstrate that the uncanny valley is overhyped, or to confirm it exists and probe its edges.

The classic experiment involves gradually morphing a cartoon face into a human face, via some robotic-seeming intermediaries—yet it’s in movement that the real horror of the almost-human often lies. Hanson has argued that incorporating cartoonish features may help—and, sometimes, that the uncanny valley is a generational thing which will melt away when new generations grow used to the quirks of robots. Although Hanson might dispute the severity of this effect, it’s clearly what he’s trying to avoid with each new iteration.

Hiroshi Ishiguro is the latest of the roboticists to have dived headlong into the valley.

Building on the work of pioneers like Hanson, those who study human-robot interaction are pushing at the boundaries of robotics—but also of social science. It’s usually difficult to simulate what you don’t understand, and there’s still an awful lot we don’t understand about how we interpret the constant streams of non-verbal information that flow when you interact with people in the flesh.

Ishiguro took this imitation of human forms to extreme levels. Not only did he monitor and log the physical movements people made on videotapes, but some of his robots are based on replicas of people; the Repliee series began with a ‘replicant’ of his daughter. This involved making a rubber replica—a silicone cast—of her entire body. Future experiments were focused on creating Geminoid, a replica of Ishiguro himself.

As Ishiguro aged, he realized that it would be more effective to resemble his replica through cosmetic surgery rather than by continually creating new casts of his face, each with more lines than the last. “I decided not to get old anymore,” Ishiguro said.

We love to throw around abstract concepts and ideas: humans being replaced by machines, cared for by machines, getting intimate with machines, or even merging themselves with machines. You can take an idea like that, hold it in your hand, and examine it—dispassionately, if not without interest. But there’s a gulf between thinking about it and living in a world where human-robot interaction is not a field of academic research, but a day-to-day reality.

As the scientists studying human-robot interaction develop their robots, their replicas, and their experiments, they are making some of the first forays into that world. We might all be living there someday. Understanding ourselves—decrypting the origins of empathy and love—may be the greatest challenge to face. That is, if you want to avoid the valley.

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#432036 The Power to Upgrade Our Own Biology Is ...

Upgrading our biology may sound like science fiction, but attempts to improve humanity actually date back thousands of years. Every day, we enhance ourselves through seemingly mundane activities such as exercising, meditating, or consuming performance-enhancing drugs, such as caffeine or adderall. However, the tools with which we upgrade our biology are improving at an accelerating rate and becoming increasingly invasive.

In recent decades, we have developed a wide array of powerful methods, such as genetic engineering and brain-machine interfaces, that are redefining our humanity. In the short run, such enhancement technologies have medical applications and may be used to treat many diseases and disabilities. Additionally, in the coming decades, they could allow us to boost our physical abilities or even digitize human consciousness.

What’s New?
Many futurists argue that our devices, such as our smartphones, are already an extension of our cortex and in many ways an abstract form of enhancement. According to philosophers Andy Clark and David Chalmers’ theory of extended mind, we use technology to expand the boundaries of the human mind beyond our skulls.

One can argue that having access to a smartphone enhances one’s cognitive capacities and abilities and is an indirect form of enhancement of its own. It can be considered an abstract form of brain-machine interface. Beyond that, wearable devices and computers are already accessible in the market, and people like athletes use them to boost their progress.

However, these interfaces are becoming less abstract.

Not long ago, Elon Musk announced a new company, Neuralink, with the goal of merging the human mind with AI. The past few years have seen remarkable developments in both the hardware and software of brain-machine interfaces. Experts are designing more intricate electrodes while programming better algorithms to interpret neural signals. Scientists have already succeeded in enabling paralyzed patients to type with their minds, and are even allowing brains to communicate with one another purely through brainwaves.

Ethical Challenges of Enhancement
There are many social and ethical implications of such advancements.

One of the most fundamental issues with cognitive and physical enhancement techniques is that they contradict the very definition of merit and success that society has relied on for millennia. Many forms of performance-enhancing drugs have been considered “cheating” for the longest time.

But perhaps we ought to revisit some of our fundamental assumptions as a society.

For example, we like to credit hard work and talent in a fair manner, where “fair” generally implies that an individual has acted in a way that has served him to merit his rewards. If you are talented and successful, it is considered to be because you chose to work hard and take advantage of the opportunities available to you. But by these standards, how much of our accomplishments can we truly be credited for?

For instance, the genetic lottery can have an enormous impact on an individual’s predisposition and personality, which can in turn affect factors such as motivation, reasoning skills, and other mental abilities. Many people are born with a natural ability or a physique that gives them an advantage in a particular area or predisposes them to learn faster. But is it justified to reward someone for excellence if their genes had a pivotal role in their path to success?

Beyond that, there are already many ways in which we take “shortcuts” to better mental performance. Seemingly mundane activities like drinking coffee, meditating, exercising, or sleeping well can boost one’s performance in any given area and are tolerated by society. Even the use of language can have positive physical and psychological effects on the human brain, which can be liberating to the individual and immensely beneficial to society at large. And let’s not forget the fact that some of us are born into more access to developing literacy than others.

Given all these reasons, one could argue that cognitive abilities and talents are currently derived more from uncontrollable factors and luck than we like to admit. If anything, technologies like brain-machine interfaces can enhance individual autonomy and allow one a choice of how capable they become.

As Karim Jebari points out (pdf), if a certain characteristic or trait is required to perform a particular role and an individual lacks this trait, would it be wrong to implement the trait through brain-machine interfaces or genetic engineering? How is this different from any conventional form of learning or acquiring a skill? If anything, this would be removing limitations on individuals that result from factors outside their control, such as biological predisposition (or even traits induced from traumatic experiences) to act or perform in a certain way.

Another major ethical concern is equality. As with any other emerging technology, there are valid concerns that cognitive enhancement tech will benefit only the wealthy, thus exacerbating current inequalities. This is where public policy and regulations can play a pivotal role in the impact of technology on society.

Enhancement technologies can either contribute to inequality or allow us to solve it. Educating and empowering the under-privileged can happen at a much more rapid rate, helping the overall rate of human progress accelerate. The “normal range” for human capacity and intelligence, however it is defined, could shift dramatically towards more positive trends.

Many have also raised concerns over the negative applications of government-led biological enhancement, including eugenics-like movements and super-soldiers. Naturally, there are also issues of safety, security, and well-being, especially within the early stages of experimentation with enhancement techniques.

Brain-machine interfaces, for instance, could have implications on autonomy. The interface involves using information extracted from the brain to stimulate or modify systems in order to accomplish a goal. This part of the process can be enhanced by implementing an artificial intelligence system onto the interface—one that exposes the possibility of a third party potentially manipulating individual’s personalities, emotions, and desires by manipulating the interface.

A Tool For Transcendence
It’s important to discuss these risks, not so that we begin to fear and avoid such technologies, but so that we continue to advance in a way that minimizes harm and allows us to optimize the benefits.

Stephen Hawking notes that “with genetic engineering, we will be able to increase the complexity of our DNA, and improve the human race.” Indeed, the potential advantages of modifying biology are revolutionary. Doctors would gain access to a powerful tool to tackle disease, allowing us to live longer and healthier lives. We might be able to extend our lifespan and tackle aging, perhaps a critical step to becoming a space-faring species. We may begin to modify the brain’s building blocks to become more intelligent and capable of solving grand challenges.

In their book Evolving Ourselves, Juan Enriquez and Steve Gullans describe a world where evolution is no longer driven by natural processes. Instead, it is driven by human choices, through what they call unnatural selection and non-random mutation. Human enhancement is bringing us closer to such a world—it could allow us to take control of our evolution and truly shape the future of our species.

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#432027 We Read This 800-Page Report on the ...

The longevity field is bustling but still fragmented, and the “silver tsunami” is coming.

That is the takeaway of The Science of Longevity, the behemoth first volume of a four-part series offering a bird’s-eye view of the longevity industry in 2017. The report, a joint production of the Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International, synthesizes the growing array of academic and industry ventures related to aging, healthspan, and everything in between.

This is huge, not only in scale but also in ambition. The report, totally worth a read here, will be followed by four additional volumes in 2018, covering topics ranging from the business side of longevity ventures to financial systems to potential tensions between life extension and religion.

And that’s just the first step. The team hopes to publish updated versions of the report annually, giving scientists, investors, and regulatory agencies an easy way to keep their finger on the longevity pulse.

“In 2018, ‘aging’ remains an unnamed adversary in an undeclared war. For all intents and purposes it is mere abstraction in the eyes of regulatory authorities worldwide,” the authors write.

That needs to change.

People often arrive at the field of aging from disparate areas with wildly diverse opinions and strengths. The report compiles these individual efforts at cracking aging into a systematic resource—a “periodic table” for longevity that clearly lays out emerging trends and promising interventions.

The ultimate goal? A global framework serving as a road map to guide the burgeoning industry. With such a framework in hand, academics and industry alike are finally poised to petition the kind of large-scale investments and regulatory changes needed to tackle aging with a unified front.

Infographic depicting many of the key research hubs and non-profits within the field of geroscience.
Image Credit: Longevity.International
The Aging Globe
The global population is rapidly aging. And our medical and social systems aren’t ready to handle this oncoming “silver tsunami.”

Take the medical field. Many age-related diseases such as Alzheimer’s lack effective treatment options. Others, including high blood pressure, stroke, lung or heart problems, require continuous medication and monitoring, placing enormous strain on medical resources.

What’s more, because disease risk rises exponentially with age, medical care for the elderly becomes a game of whack-a-mole: curing any individual disease such as cancer only increases healthy lifespan by two to three years before another one hits.

That’s why in recent years there’s been increasing support for turning the focus to the root of the problem: aging. Rather than tackling individual diseases, geroscience aims to add healthy years to our lifespan—extending “healthspan,” so to speak.

Despite this relative consensus, the field still faces a roadblock. The US FDA does not yet recognize aging as a bona fide disease. Without such a designation, scientists are banned from testing potential interventions for aging in clinical trials (that said, many have used alternate measures such as age-related biomarkers or Alzheimer’s symptoms as a proxy).

Luckily, the FDA’s stance is set to change. The promising anti-aging drug metformin, for example, is already in clinical trials, examining its effect on a variety of age-related symptoms and diseases. This report, and others to follow, may help push progress along.

“It is critical for investors, policymakers, scientists, NGOs, and influential entities to prioritize the amelioration of the geriatric world scenario and recognize aging as a critical matter of global economic security,” the authors say.

Biomedical Gerontology
The causes of aging are complex, stubborn, and not all clear.

But the report lays out two main streams of intervention with already promising results.

The first is to understand the root causes of aging and stop them before damage accumulates. It’s like meddling with cogs and other inner workings of a clock to slow it down, the authors say.

The report lays out several treatments to keep an eye on.

Geroprotective drugs is a big one. Often repurposed from drugs already on the market, these traditional small molecule drugs target a wide variety of metabolic pathways that play a role in aging. Think anti-oxidants, anti-inflammatory, and drugs that mimic caloric restriction, a proven way to extend healthspan in animal models.

More exciting are the emerging technologies. One is nanotechnology. Nanoparticles of carbon, “bucky-balls,” for example, have already been shown to fight viral infections and dangerous ion particles, as well as stimulate the immune system and extend lifespan in mice (though others question the validity of the results).

Blood is another promising, if surprising, fountain of youth: recent studies found that molecules in the blood of the young rejuvenate the heart, brain, and muscles of aged rodents, though many of these findings have yet to be replicated.

Rejuvenation Biotechnology
The second approach is repair and maintenance.

Rather than meddling with inner clockwork, here we force back the hands of a clock to set it back. The main example? Stem cell therapy.

This type of approach would especially benefit the brain, which harbors small, scattered numbers of stem cells that deplete with age. For neurodegenerative diseases like Alzheimer’s, in which neurons progressively die off, stem cell therapy could in theory replace those lost cells and mend those broken circuits.

Once a blue-sky idea, the discovery of induced pluripotent stem cells (iPSCs), where scientists can turn skin and other mature cells back into a stem-like state, hugely propelled the field into near reality. But to date, stem cells haven’t been widely adopted in clinics.

It’s “a toolkit of highly innovative, highly invasive technologies with clinical trials still a great many years off,” the authors say.

But there is a silver lining. The boom in 3D tissue printing offers an alternative approach to stem cells in replacing aging organs. Recent investment from the Methuselah Foundation and other institutions suggests interest remains high despite still being a ways from mainstream use.

A Disruptive Future
“We are finally beginning to see an industry emerge from mankind’s attempts to make sense of the biological chaos,” the authors conclude.

Looking through the trends, they identified several technologies rapidly gaining steam.

One is artificial intelligence, which is already used to bolster drug discovery. Machine learning may also help identify new longevity genes or bring personalized medicine to the clinic based on a patient’s records or biomarkers.

Another is senolytics, a class of drugs that kill off “zombie cells.” Over 10 prospective candidates are already in the pipeline, with some expected to enter the market in less than a decade, the authors say.

Finally, there’s the big gun—gene therapy. The treatment, unlike others mentioned, can directly target the root of any pathology. With a snip (or a swap), genetic tools can turn off damaging genes or switch on ones that promote a youthful profile. It is the most preventative technology at our disposal.

There have already been some success stories in animal models. Using gene therapy, rodents given a boost in telomerase activity, which lengthens the protective caps of DNA strands, live healthier for longer.

“Although it is the prospect farthest from widespread implementation, it may ultimately prove the most influential,” the authors say.

Ultimately, can we stop the silver tsunami before it strikes?

Perhaps not, the authors say. But we do have defenses: the technologies outlined in the report, though still immature, could one day stop the oncoming tidal wave in its tracks.

Now we just have to bring them out of the lab and into the real world. To push the transition along, the team launched Longevity.International, an online meeting ground that unites various stakeholders in the industry.

By providing scientists, entrepreneurs, investors, and policy-makers a platform for learning and discussion, the authors say, we may finally generate enough drive to implement our defenses against aging. The war has begun.

Read the report in full here, and watch out for others coming soon here. The second part of the report profiles 650 (!!!) longevity-focused research hubs, non-profits, scientists, conferences, and literature. It’s an enormously helpful resource—totally worth keeping it in your back pocket for future reference.

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