Tag Archives: life

#437946 Video Friday: These Robots Are Ready for ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online]
RoboSoft 2021 – April 12-16, 2021 – [Online]
Let us know if you have suggestions for next week, and enjoy today’s videos.

Is it too late to say, “Happy Holidays”? Yes! Is it too late for a post packed with holiday robot videos? Never!

The Autonomous Systems Lab at ETH Zurich wishes everyone a Merry Christmas and a Happy 2021!

Now you know the best kept secret in robotics- the ETH Zurich Autonomous Systems Lab is a shack in the woods. With an elevator.

[ ASL ]

We have had to do things differently this year, and the holiday season is no exception. But through it all, we still found ways to be together. From all of us at NATO, Happy Holidays. After training in the snow and mountains of Iceland, an EOD team returns to base. Passing signs reminding them to ‘Keep your distance’ due to COVID-19, they return to their office a little dejected, unsure how they can safely enjoy the holidays. But the EOD robot saves the day and finds a unique way to spread the holiday cheer – socially distanced, of course.

[ EATA ]

Season's Greetings from Voliro!

[ Voliro ]

Thanks Daniel!

Even if you don't have a robot at home, you can still make Halodi Robotics's gingerbread cookies the old fashioned way.

[ Halodi Robotics ]

Thanks Jesper!

We wish you all a Merry Christmas in this very different 2020. This year has truly changed the world and our way of living. We, Energy Robotics, like to say thank you to all our customers, partners, supporters, friends and family.

An Aibo ERS-7? Sweet!

[ Energy Robotics ]

Thanks Stefan!

The nickname for this drone should be “The Grinch.”

As it turns out, in real life taking samples of trees to determine how healthy they are is best done from the top.

[ DeLeaves ]

Thanks Alexis!

ETH Zurich would like to wish you happy holidays and a successful 2021 full of energy and health!

[ ETH Zurich ]

The QBrobotics Team wishes you all a Merry Christmas and a Happy New Year!

[ QBrobotics ]

Extend Robotics avatar twin got so excited opening a Christmas gift, using two arms coordinating, showing the dexterity and speed.

[ Extend Robotics ]

HEBI Robotics wishes everyone a great holiday season! Onto 2021!

[ HEBI Robotics ]

Christmas at the Mobile Robots Lab at Poznan Polytechnic.

[ Poznan ]

SWarm Holiday Wishes from the Hauert Lab!

[ Hauert Lab ]

Brubotics-VUB SMART and SHERO team wishes you a Merry Christmas and Happy 2021!

[ SMART ]

Success is all about teamwork! Thank you for supporting PAL Robotics. This festive season enjoy and stay safe!

[ PAL Robotics ]

Our robots wish you Happy Holidays! Starring world's first robot slackliner (Leonardo)!

[ Caltech ]

Happy Holidays and a Prosperous New Year from ZenRobotics!

[ ZenRobotics ]

Our Highly Dexterous Manipulation System (HDMS) dual-arm robot is ringing in the new year with good cheer!

[ RE2 Robotics ]

Happy Holidays 2020 from NAO!

[ SoftBank Robotics ]

Happy Holidays from DENSO Robotics!

[ DENSO ] Continue reading

Posted in Human Robots

#437929 These Were Our Favorite Tech Stories ...

This time last year we were commemorating the end of a decade and looking ahead to the next one. Enter the year that felt like a decade all by itself: 2020. News written in January, the before-times, feels hopelessly out of touch with all that came after. Stories published in the early days of the pandemic are, for the most part, similarly naive.

The year’s news cycle was swift and brutal, ping-ponging from pandemic to extreme social and political tension, whipsawing economies, and natural disasters. Hope. Despair. Loneliness. Grief. Grit. More hope. Another lockdown. It’s been a hell of a year.

Though 2020 was dominated by big, hairy societal change, science and technology took significant steps forward. Researchers singularly focused on the pandemic and collaborated on solutions to a degree never before seen. New technologies converged to deliver vaccines in record time. The dark side of tech, from biased algorithms to the threat of omnipresent surveillance and corporate control of artificial intelligence, continued to rear its head.

Meanwhile, AI showed uncanny command of language, joined Reddit threads, and made inroads into some of science’s grandest challenges. Mars rockets flew for the first time, and a private company delivered astronauts to the International Space Station. Deprived of night life, concerts, and festivals, millions traveled to virtual worlds instead. Anonymous jet packs flew over LA. Mysterious monoliths appeared and disappeared worldwide.

It was all, you know, very 2020. For this year’s (in-no-way-all-encompassing) list of fascinating stories in tech and science, we tried to select those that weren’t totally dated by the news, but rose above it in some way. So, without further ado: This year’s picks.

How Science Beat the Virus
Ed Yong | The Atlantic
“Much like famous initiatives such as the Manhattan Project and the Apollo program, epidemics focus the energies of large groups of scientists. …But ‘nothing in history was even close to the level of pivoting that’s happening right now,’ Madhukar Pai of McGill University told me. … No other disease has been scrutinized so intensely, by so much combined intellect, in so brief a time.”

‘It Will Change Everything’: DeepMind’s AI Makes Gigantic Leap in Solving Protein Structures
Ewen Callaway | Nature
“In some cases, AlphaFold’s structure predictions were indistinguishable from those determined using ‘gold standard’ experimental methods such as X-ray crystallography and, in recent years, cryo-electron microscopy (cryo-EM). AlphaFold might not obviate the need for these laborious and expensive methods—yet—say scientists, but the AI will make it possible to study living things in new ways.”

OpenAI’s Latest Breakthrough Is Astonishingly Powerful, But Still Fighting Its Flaws
James Vincent | The Verge
“What makes GPT-3 amazing, they say, is not that it can tell you that the capital of Paraguay is Asunción (it is) or that 466 times 23.5 is 10,987 (it’s not), but that it’s capable of answering both questions and many more beside simply because it was trained on more data for longer than other programs. If there’s one thing we know that the world is creating more and more of, it’s data and computing power, which means GPT-3’s descendants are only going to get more clever.”

Artificial General Intelligence: Are We Close, and Does It Even Make Sense to Try?
Will Douglas Heaven | MIT Technology Review
“A machine that could think like a person has been the guiding vision of AI research since the earliest days—and remains its most divisive idea. …So why is AGI controversial? Why does it matter? And is it a reckless, misleading dream—or the ultimate goal?”

The Dark Side of Big Tech’s Funding for AI Research
Tom Simonite | Wired
“Timnit Gebru’s exit from Google is a powerful reminder of how thoroughly companies dominate the field, with the biggest computers and the most resources. …[Meredith] Whittaker of AI Now says properly probing the societal effects of AI is fundamentally incompatible with corporate labs. ‘That kind of research that looks at the power and politics of AI is and must be inherently adversarial to the firms that are profiting from this technology.’i”

We’re Not Prepared for the End of Moore’s Law
David Rotman | MIT Technology Review
“Quantum computing, carbon nanotube transistors, even spintronics, are enticing possibilities—but none are obvious replacements for the promise that Gordon Moore first saw in a simple integrated circuit. We need the research investments now to find out, though. Because one prediction is pretty much certain to come true: we’re always going to want more computing power.”

Inside the Race to Build the Best Quantum Computer on Earth
Gideon Lichfield | MIT Technology Review
“Regardless of whether you agree with Google’s position [on ‘quantum supremacy’] or IBM’s, the next goal is clear, Oliver says: to build a quantum computer that can do something useful. …The trouble is that it’s nearly impossible to predict what the first useful task will be, or how big a computer will be needed to perform it.”

The Secretive Company That Might End Privacy as We Know It
Kashmir Hill | The New York Times
“Searching someone by face could become as easy as Googling a name. Strangers would be able to listen in on sensitive conversations, take photos of the participants and know personal secrets. Someone walking down the street would be immediately identifiable—and his or her home address would be only a few clicks away. It would herald the end of public anonymity.”

Wrongfully Accused by an Algorithm
Kashmir Hill | The New York Times
“Mr. Williams knew that he had not committed the crime in question. What he could not have known, as he sat in the interrogation room, is that his case may be the first known account of an American being wrongfully arrested based on a flawed match from a facial recognition algorithm, according to experts on technology and the law.”

Predictive Policing Algorithms Are Racist. They Need to Be Dismantled.
Will Douglas Heaven | MIT Technology Review
“A number of studies have shown that these tools perpetuate systemic racism, and yet we still know very little about how they work, who is using them, and for what purpose. All of this needs to change before a proper reckoning can take pace. Luckily, the tide may be turning.”

The Panopticon Is Already Here
Ross Andersen | The Atlantic
“Artificial intelligence has applications in nearly every human domain, from the instant translation of spoken language to early viral-outbreak detection. But Xi [Jinping] also wants to use AI’s awesome analytical powers to push China to the cutting edge of surveillance. He wants to build an all-seeing digital system of social control, patrolled by precog algorithms that identify potential dissenters in real time.”

The Case For Cities That Aren’t Dystopian Surveillance States
Cory Doctorow | The Guardian
“Imagine a human-centered smart city that knows everything it can about things. It knows how many seats are free on every bus, it knows how busy every road is, it knows where there are short-hire bikes available and where there are potholes. …What it doesn’t know is anything about individuals in the city.”

The Modern World Has Finally Become Too Complex for Any of Us to Understand
Tim Maughan | OneZero
“One of the dominant themes of the last few years is that nothing makes sense. …I am here to tell you that the reason so much of the world seems incomprehensible is that it is incomprehensible. From social media to the global economy to supply chains, our lives rest precariously on systems that have become so complex, and we have yielded so much of it to technologies and autonomous actors that no one totally comprehends it all.”

The Conscience of Silicon Valley
Zach Baron | GQ
“What I really hoped to do, I said, was to talk about the future and how to live in it. This year feels like a crossroads; I do not need to explain what I mean by this. …I want to destroy my computer, through which I now work and ‘have drinks’ and stare at blurry simulations of my parents sometimes; I want to kneel down and pray to it like a god. I want someone—I want Jaron Lanier—to tell me where we’re going, and whether it’s going to be okay when we get there. Lanier just nodded. All right, then.”

Yes to Tech Optimism. And Pessimism.
Shira Ovide | The New York Times
“Technology is not something that exists in a bubble; it is a phenomenon that changes how we live or how our world works in ways that help and hurt. That calls for more humility and bridges across the optimism-pessimism divide from people who make technology, those of us who write about it, government officials and the public. We need to think on the bright side. And we need to consider the horribles.”

How Afrofuturism Can Help the World Mend
C. Brandon Ogbunu | Wired
“…[W. E. B. DuBois’] ‘The Comet’ helped lay the foundation for a paradigm known as Afrofuturism. A century later, as a comet carrying disease and social unrest has upended the world, Afrofuturism may be more relevant than ever. Its vision can help guide us out of the rubble, and help us to consider universes of better alternatives.”

Wikipedia Is the Last Best Place on the Internet
Richard Cooke | Wired
“More than an encyclopedia, Wikipedia has become a community, a library, a constitution, an experiment, a political manifesto—the closest thing there is to an online public square. It is one of the few remaining places that retains the faintly utopian glow of the early World Wide Web.”

Can Genetic Engineering Bring Back the American Chestnut?
Gabriel Popkin | The New York Times Magazine
“The geneticists’ research forces conservationists to confront, in a new and sometimes discomfiting way, the prospect that repairing the natural world does not necessarily mean returning to an unblemished Eden. It may instead mean embracing a role that we’ve already assumed: engineers of everything, including nature.”

At the Limits of Thought
David C. Krakauer | Aeon
“A schism is emerging in the scientific enterprise. On the one side is the human mind, the source of every story, theory, and explanation that our species holds dear. On the other stand the machines, whose algorithms possess astonishing predictive power but whose inner workings remain radically opaque to human observers.”

Is the Internet Conscious? If It Were, How Would We Know?
Meghan O’Gieblyn | Wired
“Does the internet behave like a creature with an internal life? Does it manifest the fruits of consciousness? There are certainly moments when it seems to. Google can anticipate what you’re going to type before you fully articulate it to yourself. Facebook ads can intuit that a woman is pregnant before she tells her family and friends. It is easy, in such moments, to conclude that you’re in the presence of another mind—though given the human tendency to anthropomorphize, we should be wary of quick conclusions.”

The Internet Is an Amnesia Machine
Simon Pitt | OneZero
“There was a time when I didn’t know what a Baby Yoda was. Then there was a time I couldn’t go online without reading about Baby Yoda. And now, Baby Yoda is a distant, shrugging memory. Soon there will be a generation of people who missed the whole thing and for whom Baby Yoda is as meaningless as it was for me a year ago.”

Digital Pregnancy Tests Are Almost as Powerful as the Original IBM PC
Tom Warren | The Verge
“Each test, which costs less than $5, includes a processor, RAM, a button cell battery, and a tiny LCD screen to display the result. …Foone speculates that this device is ‘probably faster at number crunching and basic I/O than the CPU used in the original IBM PC.’ IBM’s original PC was based on Intel’s 8088 microprocessor, an 8-bit chip that operated at 5Mhz. The difference here is that this is a pregnancy test you pee on and then throw away.”

The Party Goes on in Massive Online Worlds
Cecilia D’Anastasio | Wired
“We’re more stand-outside types than the types to cast a flashy glamour spell and chat up the nearest cat girl. But, hey, it’s Final Fantasy XIV online, and where my body sat in New York, the epicenter of America’s Covid-19 outbreak, there certainly weren’t any parties.”

The Facebook Groups Where People Pretend the Pandemic Isn’t Happening
Kaitlyn Tiffany | The Atlantic
“Losing track of a friend in a packed bar or screaming to be heard over a live band is not something that’s happening much in the real world at the moment, but it happens all the time in the 2,100-person Facebook group ‘a group where we all pretend we’re in the same venue.’ So does losing shoes and Juul pods, and shouting matches over which bands are the saddest, and therefore the greatest.”

Did You Fly a Jetpack Over Los Angeles This Weekend? Because the FBI Is Looking for You
Tom McKay | Gizmodo
“Did you fly a jetpack over Los Angeles at approximately 3,000 feet on Sunday? Some kind of tiny helicopter? Maybe a lawn chair with balloons tied to it? If the answer to any of the above questions is ‘yes,’ you should probably lay low for a while (by which I mean cool it on the single-occupant flying machine). That’s because passing airline pilots spotted you, and now it’s this whole thing with the FBI and the Federal Aviation Administration, both of which are investigating.”

Image Credit: Thomas Kinto / Unsplash Continue reading

Posted in Human Robots

#437892 This Week’s Awesome Tech Stories From ...

ENVIRONMENT
Human-Made Stuff Now Outweighs All Life on Earth
Stephanie Pappas | Scientific American
“Humanity has reached a new milestone in its dominance of the planet: human-made objects may now outweigh all of the living beings on Earth. Roads, houses, shopping malls, fishing vessels, printer paper, coffee mugs, smartphones and all the other infrastructure of daily life now weigh in at approximately 1.1 trillion metric tons—equal to the combined dry weight of all plants, animals, fungi, bacteria, archaea and protists on the planet.”

SPACE
So, It Turns Out SpaceX Is Pretty Good at Rocketing
Eric Berger | Ars Technica
“As the Sun sank toward the South Texas horizon, a fantastical-looking spaceship rose into the reddening sky. It was, in a word, epic. …This was one heck of a test-flight that addressed a number of unknowns about Starship, which is the upper stage of SpaceX’s new launch system and may one day land humans on the Moon, Mars, and beyond.”

ARTIFICIAL INTELLIGENCE
Tiny Four-Bit Computers Are All You Need to Train AI
Karen Hao | MIT Technology Review
“The work…could increase the speed and cut the energy costs needed to train deep learning by more than sevenfold. It could also make training powerful AI models possible on smartphones and other small devices, which would improve privacy by helping to keep personal data on a local device. And it would make the process more accessible to researchers outside big, resource-rich tech companies.”

ENERGY
Did Quantum Scape Just Solve a 40-Year-Old Battery Problem?
Daniel Oberhaus | Wired
“[The properties of solid state batteries] would send…energy density through the roof, enable ultra-fast charging, and would eliminate the risk of battery fires. But for the past 40 years, no one has been able to make a solid-state battery that delivers on this promise—until earlier this year, when a secretive startup called QuantumScape claimed to have solved the problem. Now it has the data to prove it.”

ROBOTICS
Hyundai Buys Boston Dynamics for Nearly $1 Billion. Now What?
Evan Ackerman | IEEE Spectrum
“I hope that Boston Dynamics is unique enough that the kinds of rules that normally apply to robotics companies (or companies in general) can be set aside, at least somewhat, but I also worry that what made Boston Dynamics great was the explicit funding for the kinds of radical ideas that eventually resulted in robots like Atlas and Spot. Can Hyundai continue giving Boston Dynamics the support and freedom that they need to keep doing the kinds of things that have made them legendary? I certainly hope so.”

BIOTECH
CRISPR and Another Genetic Strategy Fix Cell Defects in Two Common Blood Disorders
Jocelyn Kaiser | Science
“It is a double milestone: new evidence that cures are possible for many people born with sickle cell disease and another serious blood disorder, beta-thalassemia, and a first for the genome editor CRISPR. Today, in The New England Journal of Medicine (NEJM) and tomorrow at the American Society of Hematology (ASH) meeting, teams report that two strategies for directly fixing malfunctioning blood cells have dramatically improved the health of a handful of people with these genetic diseases.”

ETHICS
The Dark Side of Big Tech’s Funding for AI Research
Tom Simonite | Wired
“Timnit Gebru’s exit from Google is a powerful reminder of how thoroughly companies dominate the field, with the biggest computers and the most resources. …[Meredith] Whittaker of AI Now says properly probing the societal effects of AI is fundamentally incompatible with corporate labs. ‘That kind of research that looks at the power and politics of AI is and must be inherently adversarial to the firms that are profiting from this technology.’i”

Image credit: Karsten Winegeart / Unsplash Continue reading

Posted in Human Robots

#437882 Video Friday: MIT Mini-Cheetah Robots ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

ICCR 2020 – December 26-29, 2020 – [Online Conference]
HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
Let us know if you have suggestions for next week, and enjoy today's videos.

What a lovely Christmas video from Norlab.

[ Norlab ]

Thanks Francois!

MIT Mini-Cheetahs are looking for a new home. Our new cheetah cubs, born at NAVER LABS, are for the MIT Mini-Cheetah workshop. MIT professor Sangbae Kim and his research team are supporting joint research by distributing Mini-Cheetahs to researchers all around the world.

[ NAVER Labs ]

For several years, NVIDIA’s research teams have been working to leverage GPU technology to accelerate reinforcement learning (RL). As a result of this promising research, NVIDIA is pleased to announce a preview release of Isaac Gym – NVIDIA’s physics simulation environment for reinforcement learning research. RL-based training is now more accessible as tasks that once required thousands of CPU cores can now instead be trained using a single GPU.

[ NVIDIA ]

At SINTEF in Norway, they're working on ways of using robots to keep tabs on giant floating cages of tasty fish:

One of the tricky things about operating robots in an environment like this is localization, so SINTEF is working on a solution that uses beacons:

While that video shows a lot of simulation (because otherwise there are tons of fish in the way), we're told that the autonomous navigation has been successfully demonstrated with an ROV in “a full scale fish farm with up to 200.000 salmon swimming around the robot.”

[ SINTEF ]

Thanks Eleni!

We’ve been getting ready for the snow in the most BG way possible. Wishing all of you a happy and healthy holiday season.

[ Berkshire Grey ]

ANYbotics doesn’t care what time of the year it is, so Happy Easter!

And here's a little bit about why ANYmal C looks the way it does.

[ ANYbotics ]

Robert “Buz” Chmielewski is using two modular prosthetic limbs developed by APL to feed himself dessert. Smart software puts his utensils in roughly the right spot, and then Buz uses his brain signals to cut the food with knife and fork. Once he is done cutting, the software then brings the food near his mouth, where he again uses brain signals to bring the food the last several inches to his mouth so that he can eat it.

[ JHUAPL ]

Introducing VESPER: a new military-grade small drone that is designed, sourced and built in the United States. Vesper offers a 50-minutes flight time, with speeds up to 45 mph (72 kph) and a total flight range of 25 miles (45 km). The magnetic snap-together architecture enables extremely fast transitions: the battery, props and rotor set can each be swapped in <5 seconds.

[ Vantage Robotics ]

In this video, a multi-material robot simulator is used to design a shape-changing robot, which is then transferred to physical hardware. The simulated and real robots can use shape change to switch between rolling gaits and inchworm gaits, to locomote in multiple environments.

[ Yale Faboratory ]

Get a preview of the cave environments that are being used to inspire the Final Event competition course of the DARPA Subterranean Challenge. In the Final Event, teams will deploy their robots to rapidly map, navigate, and search in competition courses that combine elements of man-made tunnel systems, urban underground, and natural cave networks!

The reason to pay attention this particular video is that it gives us some idea of what DARPA means when they say "cave."

[ SubT ]

MQ25 takes another step toward unmanned aerial refueling for the U.S. Navy. The MQ-25 test asset has flown for the first time with an aerial refueling pod containing the hose and basket that will make it an aerial refueler.

[ Boeing ]

We present a unified model-based and data-driven approach for quadrupedal planning and control to achieve dynamic locomotion over uneven terrain. We utilize on-board proprioceptive and exteroceptive feedback to map sensory information and desired base velocity commands into footstep plans using a reinforcement learning (RL) policy trained in simulation over a wide range of procedurally generated terrains.

[ DRS ]

The video shows the results of the German research project RoPHa. Within the project, the partners developed technologies for two application scenarios with the service robot Care-O-bot 4 in order to support people in need of help when eating.

[ RoPHa Project ]

Thanks Jenny!

This looks like it would be fun, if you are a crazy person.

[ Team BlackSheep ]

Robot accuracy is the limiting factor in many industrial applications. Manufacturers often only specify the pose repeatability values of their robotic systems. Fraunhofer IPA has set up a testing environment for automated measuring of accuracy performance criteria of industrial robots. Following the procedures defined in norm ISO 9283 allows generating reliable and repeatable results. They can be the basis for targeted measures increasing the robotic system’s accuracy.

[ Fraunhofer ]

Thanks Jenny!

The IEEE Women in Engineering – Robotics and Automation Society (WIE-RAS) hosted an online panel on best practices for teaching robotics. The diverse panel boasts experts in robotics education from a variety of disciplines, institutions, and areas of expertise.

[ IEEE RAS ]

Northwestern researchers have developed a first-of-its-kind soft, aquatic robot that is powered by light and rotating magnetic fields. These life-like robotic materials could someday be used as "smart" microscopic systems for production of fuels and drugs, environmental cleanup or transformative medical procedures.

[ Northwestern ]

Tech United Eindhoven's soccer robots now have eight wheels instead of four wheels, making them tweleve times better, if my math is right.

[ TU Eindhoven ] Continue reading

Posted in Human Robots

#437872 AlphaFold Proves That AI Can Crack ...

Any successful implementation of artificial intelligence hinges on asking the right questions in the right way. That’s what the British AI company DeepMind (a subsidiary of Alphabet) accomplished when it used its neural network to tackle one of biology’s grand challenges, the protein-folding problem. Its neural net, known as AlphaFold, was able to predict the 3D structures of proteins based on their amino acid sequences with unprecedented accuracy.

AlphaFold’s predictions at the 14th Critical Assessment of protein Structure Prediction (CASP14) were accurate to within an atom’s width for most of the proteins. The competition consisted of blindly predicting the structure of proteins that have only recently been experimentally determined—with some still awaiting determination.

Called the building blocks of life, proteins consist of 20 different amino acids in various combinations and sequences. A protein's biological function is tied to its 3D structure. Therefore, knowledge of the final folded shape is essential to understanding how a specific protein works—such as how they interact with other biomolecules, how they may be controlled or modified, and so on. “Being able to predict structure from sequence is the first real step towards protein design,” says Janet M. Thornton, director emeritus of the European Bioinformatics Institute. It also has enormous benefits in understanding disease-causing pathogens. For instance, at the moment only about 18 of the 26 proteins in the SARS-CoV-2 virus are known.

Predicting a protein’s 3D structure is a computational nightmare. In 1969 Cyrus Levinthal estimated that there are 10300 possible conformational combinations for a single protein, which would take longer than the age of the known universe to evaluate by brute force calculation. AlphaFold can do it in a few days.

As scientific breakthroughs go, AlphaFold’s discovery is right up there with the likes of James Watson and Francis Crick’s DNA double-helix model, or, more recently, Jennifer Doudna and Emmanuelle Charpentier’s CRISPR-Cas9 genome editing technique.

How did a team that just a few years ago was teaching an AI to master a 3,000-year-old game end up training one to answer a question plaguing biologists for five decades? That, says Briana Brownell, data scientist and founder of the AI company PureStrategy, is the beauty of artificial intelligence: The same kind of algorithm can be used for very different things.

“Whenever you have a problem that you want to solve with AI,” she says, “you need to figure out how to get the right data into the model—and then the right sort of output that you can translate back into the real world.”

DeepMind’s success, she says, wasn’t so much a function of picking the right neural nets but rather “how they set up the problem in a sophisticated enough way that the neural network-based modeling [could] actually answer the question.”

AlphaFold showed promise in 2018, when DeepMind introduced a previous iteration of their AI at CASP13, achieving the highest accuracy among all participants. The team had trained its to model target shapes from scratch, without using previously solved proteins as templates.

For 2020 they deployed new deep learning architectures into the AI, using an attention-based model that was trained end-to-end. Attention in a deep learning network refers to a component that manages and quantifies the interdependence between the input and output elements, as well as between the input elements themselves.

The system was trained on public datasets of the approximately 170,000 known experimental protein structures in addition to databases with protein sequences of unknown structures.

“If you look at the difference between their entry two years ago and this one, the structure of the AI system was different,” says Brownell. “This time, they’ve figured out how to translate the real world into data … [and] created an output that could be translated back into the real world.”

Like any AI system, AlphaFold may need to contend with biases in the training data. For instance, Brownell says, AlphaFold is using available information about protein structure that has been measured in other ways. However, there are also many proteins with as yet unknown 3D structures. Therefore, she says, a bias could conceivably creep in toward those kinds of proteins that we have more structural data for.

Thornton says it’s difficult to predict how long it will take for AlphaFold’s breakthrough to translate into real-world applications.

“We only have experimental structures for about 10 per cent of the 20,000 proteins [in] the human body,” she says. “A powerful AI model could unveil the structures of the other 90 per cent.”

Apart from increasing our understanding of human biology and health, she adds, “it is the first real step toward… building proteins that fulfill a specific function. From protein therapeutics to biofuels or enzymes that eat plastic, the possibilities are endless.” Continue reading

Posted in Human Robots