Tag Archives: laboratory

#435656 Will AI Be Fashion Forward—or a ...

Posted on September 15, 2019 by Android

The narrative that often accompanies most stories about artificial intelligence these days is how machines will disrupt any number of industries, from healthcare to transportation. It makes sense. After all, technology already drives many of the innovations in these sectors of the economy.

But sneakers and the red carpet? The definitively low-tech fashion industry would seem to be one of the last to turn over its creative direction to data scientists and machine learning algorithms.

However, big brands, e-commerce giants, and numerous startups are betting that AI can ingest data and spit out Chanel. Maybe it’s not surprising, given that fashion is partly about buzz and trends—and there’s nothing more buzzy and trendy in the world of tech today than AI.

In its annual survey of the $3 trillion fashion industry, consulting firm McKinsey predicted that while AI didn’t hit a “critical mass” in 2018, it would increasingly influence the business of everything from design to manufacturing.

“Fashion as an industry really has been so slow to understand its potential roles interwoven with technology. And, to be perfectly honest, the technology doesn’t take fashion seriously.” This comment comes from Zowie Broach, head of fashion at London’s Royal College of Arts, who as a self-described “old fashioned” designer has embraced the disruptive nature of technology—with some caveats.

Co-founder in the late 1990s of the avant-garde fashion label Boudicca, Broach has always seen tech as a tool for designers, even setting up a website for the company circa 1998, way before an online presence became, well, fashionable.

Broach told Singularity Hub that while she is generally optimistic about the future of technology in fashion—the designer has avidly been consuming old sci-fi novels over the last few years—there are still a lot of difficult questions to answer about the interface of algorithms, art, and apparel.

For instance, can AI do what the great designers of the past have done? Fashion was “about designing, it was about a narrative, it was about meaning, it was about expression,” according to Broach.

AI that designs products based on data gleaned from human behavior can potentially tap into the Pavlovian response in consumers in order to make money, Broach noted. But is that channeling creativity, or just digitally dabbling in basic human brain chemistry?

She is concerned about people retaining control of the process, whether we’re talking about their data or their designs. But being empowered with the insights machines could provide into, for example, the geographical nuances of fashion between Dubai, Moscow, and Toronto is thrilling.

“What is it that we want the future to be from a fashion, an identity, and design perspective?” she asked.

Off on the Right Foot
Silicon Valley and some of the biggest brands in the industry offer a few answers about where AI and fashion are headed (though not at the sort of depths that address Broach’s broader questions of aesthetics and ethics).

Take what is arguably the biggest brand in fashion, at least by market cap but probably not by the measure of appearances on Oscar night: Nike. The $100 billion shoe company just gobbled up an AI startup called Celect to bolster its data analytics and optimize its inventory. In other words, Nike hopes it will be able to figure out what’s hot and what’s not in a particular location to stock its stores more efficiently.

The company is going even further with Nike Fit, a foot-scanning platform using a smartphone camera that applies AI techniques from fields like computer vision and machine learning to find the best fit for each person’s foot. The algorithms then identify and recommend the appropriately sized and shaped shoe in different styles.

No doubt the next step will be to 3D print personalized and on-demand sneakers at any store.

San Francisco-based startup ThirdLove is trying to bring a similar approach to bra sizes. Its 20-member data team, Fortune reported, has developed the Fit Finder quiz that uses machine learning algorithms to help pick just the right garment for every body type.

Data scientists are also a big part of the team at Stitch Fix, a former San Francisco startup that went public in 2017 and today sports a market cap of more than $2 billion. The online “personal styling” company uses hundreds of algorithms to not only make recommendations to customers, but to help design new styles and even manage the subscription-based supply chain.

Future of Fashion
E-commerce giant Amazon has thrown its own considerable resources into developing AI applications for retail fashion—with mixed results.

One notable attempt involved a “styling assistant” that came with the company’s Echo Look camera that helped people catalog and manage their wardrobes, evening helping pick out each day’s attire. The company more recently revisited the direct consumer side of AI with an app called StyleSnap, which matches clothes and accessories uploaded to the site with the retailer’s vast inventory and recommends similar styles.

Behind the curtains, Amazon is going even further. A team of researchers in Israel have developed algorithms that can deduce whether a particular look is stylish based on a few labeled images. Another group at the company’s San Francisco research center was working on tech that could generate new designs of items based on images of a particular style the algorithms trained on.

“I will say that the accumulation of many new technologies across the industry could manifest in a highly specialized style assistant, far better than the examples we’ve seen today. However, the most likely thing is that the least sexy of the machine learning work will become the most impactful, and the public may never hear about it.”

That prediction is from an online interview with Leanne Luce, a fashion technology blogger and product manager at Google who recently wrote a book called, succinctly enough, Artificial Intelligence and Fashion.

Data Meets Design
Academics are also sticking their beakers into AI and fashion. Researchers at the University of California, San Diego, and Adobe Research have previously demonstrated that neural networks, a type of AI designed to mimic some aspects of the human brain, can be trained to generate (i.e., design) new product images to match a buyer’s preference, much like the team at Amazon.

Meanwhile, scientists at Hong Kong Polytechnic University are working with China’s answer to Amazon, Alibaba, on developing a FashionAI Dataset to help machines better understand fashion. The effort will focus on how algorithms approach certain building blocks of design, what are called “key points” such as neckline and waistline, and “fashion attributes” like collar types and skirt styles.

The man largely behind the university’s research team is Calvin Wong, a professor and associate head of Hong Kong Polytechnic University’s Institute of Textiles and Clothing. His group has also developed an “intelligent fabric defect detection system” called WiseEye for quality control, reducing the chance of producing substandard fabric by 90 percent.

Wong and company also recently inked an agreement with RCA to establish an AI-powered design laboratory, though the details of that venture have yet to be worked out, according to Broach.

One hope is that such collaborations will not just get at the technological challenges of using machines in creative endeavors like fashion, but will also address the more personal relationships humans have with their machines.

“I think who we are, and how we use AI in fashion, as our identity, is not a superficial skin. It’s very, very important for how we define our future,” Broach said.

Image Credit: Inspirationfeed / Unsplash Continue reading →

Posted in Human Robots

#435591 Video Friday: This Robotic Thread Could ...

Posted on September 11, 2019 by Android

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

IEEE Africon 2019 – September 25-27, 2019 – Accra, Ghana
ISRR 2019 – October 6-10, 2019 – Hanoi, Vietnam
Ro-Man 2019 – October 14-18, 2019 – New Delhi, India
Humanoids 2019 – October 15-17, 2019 – Toronto, Canada
ARSO 2019 – October 31-1, 2019 – Beijing, China
ROSCon 2019 – October 31-1, 2019 – Macau
IROS 2019 – November 4-8, 2019 – Macau
Let us know if you have suggestions for next week, and enjoy today’s videos.

Eight engineering students from ETH Zurich are working on a year-long focus project to develop a multimodal robot called Dipper, which can fly, swim, dive underwater, and manage that difficult air-water transition:

The robot uses one motor to selectively drive either a propeller or a marine screw depending on whether it’s in flight or not. We’re told that getting the robot to autonomously do the water to air transition is still a work in progress, but that within a few weeks things should be much smoother.

[ Dipper ]

Thanks Simon!

Giving a jellyfish a hug without stressing them out is exactly as hard as you think, but Harvard’s robot will make sure that all jellyfish get the emotional (and physical) support that they need.

The gripper’s six “fingers” are composed of thin, flat strips of silicone with a hollow channel inside bonded to a layer of flexible but stiffer polymer nanofibers. The fingers are attached to a rectangular, 3D-printed plastic “palm” and, when their channels are filled with water, curl in the direction of the nanofiber-coated side. Each finger exerts an extremely low amount of pressure — about 0.0455 kPA, or less than one-tenth of the pressure of a human’s eyelid on their eye. By contrast, current state-of-the-art soft marine grippers, which are used to capture delicate but more robust animals than jellyfish, exert about 1 kPA.

The gripper was successfully able to trap each jellyfish against the palm of the device, and the jellyfish were unable to break free from the fingers’ grasp until the gripper was depressurized. The jellyfish showed no signs of stress or other adverse effects after being released, and the fingers were able to open and close roughly 100 times before showing signs of wear and tear.

[ Harvard ]

MIT engineers have developed a magnetically steerable, thread-like robot that can actively glide through narrow, winding pathways, such as the labyrinthine vasculature of the brain. In the future, this robotic thread may be paired with existing endovascular technologies, enabling doctors to remotely guide the robot through a patient’s brain vessels to quickly treat blockages and lesions, such as those that occur in aneurysms and stroke.

[ MIT ]

See NASA’s next Mars rover quite literally coming together inside a clean room at the Jet Propulsion Laboratory. This behind-the-scenes look at what goes into building and preparing a rover for Mars, including extensive tests in simulated space environments, was captured from March to July 2019. The rover is expected to launch to the Red Planet in summer 2020 and touch down in February 2021.

The Mars 2020 rover doesn’t have a name yet, but you can give it one! As long as you’re not too old! Which you probably are!

[ Mars 2020 ]

I desperately wish that we could watch this next video at normal speed, not just slowed down, but it’s quite impressive anyway.

Here’s one more video from the Namiki Lab showing some high speed tracking with a pair of very enthusiastic robotic cameras:

[ Namiki Lab ]

Normally, tedious modeling of mechanics, electronics, and information science is required to understand how insects’ or robots’ moving parts coordinate smoothly to take them places. But in a new study, biomechanics researchers at the Georgia Institute of Technology boiled down the sprints of cockroaches to handy principles and equations they then used to make a test robot amble about better.

[ Georgia Tech ]

More magical obstacle-dodging footage from Skydio’s still secret new drone.

We’ve been hard at work extending the capabilities of our upcoming drone, giving you ways to get the control you want without the stress of crashing. The result is you can fly in ways, and get shots, that would simply be impossible any other way. How about flying through obstacles at full speed, backwards?

[ Skydio ]

This is a cute demo with Misty:

[ Misty Robotics ]

We’ve seen pieces of hardware like this before, but always made out of hard materials—a soft version is certainly something new.

Utilizing vacuum power and soft material actuators, we have developed a soft reconfigurable surface (SRS) with multi-modal control and performance capabilities. The SRS is comprised of a square grid array of linear vacuum-powered soft pneumatic actuators (linear V-SPAs), built into plug-and-play modules which enable the arrangement, consolidation, and control of many DoF.

[ RRL ]

The EksoVest is not really a robot, but it’ll make you a cyborg! With super strength!

“This is NOT intended to give you super strength but instead give you super endurance and reduce fatigue so that you have more energy and less soreness at the end of your shift.”

Drat!

[ EksoVest ]

We have created a solution for parents, grandparents, and their children who are living separated. This is an amazing tool to stay connected from a distance through the intimacy that comes through interactive play with a child. For parents who travel for work, deployed military, and families spread across the country, the Cushybot One is much more than a toy; it is the opportunity for maintaining a deep connection with your young child from a distance.

Hmm.

I think the concept here is great, but it’s going to be a serious challenge to successfully commercialize.

[ Indiegogo ]

What happens when you equip RVR with a parachute and send it off a cliff? Watch this episode of RVR Launchpad to find out – then go Behind the Build to see how we (eventually) accomplished this high-flying feat.

[ Sphero ]

These omnidirectional crawler robots aren’t new, but that doesn’t keep them from being fun to watch.

[ NEDO ] via [ Impress ]

We’ll finish up the week with a couple of past ICRA and IROS keynote talks—one by Gill Pratt on The Reliability Challenges of Autonomous Driving, and the other from Peter Hart, on Making Shakey.

[ IEEE RAS ] Continue reading →

Posted in Human Robots

#435579 RoMeLa’s Newest Robot Is a ...

Posted on September 11, 2019 by Android

A few years ago, we wrote about NABiRoS, a bipedal robot from Dennis Hong’s Robotics & Mechanisms Laboratory (RoMeLa) at UCLA. Unlike pretty much any other biped we’d ever seen, NABiRoS had a unique kinematic configuration that had it using its two legs to walk sideways, which offered some surprising advantages.

As it turns out, bipeds aren’t the only robots that can potentially benefit from a bit of a kinematic rethink. RoMeLa has redesigned quadrupedal robots too—rather than model them after a quadrupedal animal like a dog or a horse, RoMeLa’s ALPHRED robots use four legs arranged symmetrically around the body of the robot, allowing it to walk, run, hop, and jump, as well as manipulate and carry objects, karate chop through boards, and even roller skate on its butt. This robot can do it all.

Impressive, right? This is ALPHRED 2, and its predecessor, the original ALPHRED, was introduced at IROS 2018. Both ALPHREDs are axisymmetric about the vertical axis, meaning that they don’t have a front or a back and are perfectly happy to walk in any direction you like. Traditional quadrupeds like Spot or Laikago can also move sideways and backwards, but their leg arrangement makes them more efficient at moving in one particular direction, and also results in some curious compromises like a preference for going down stairs backwards. ANYmal is a bit more flexible in that it can reverse its knees, but it’s still got that traditional quadrupedal two-by-two configuration.

ALPHRED 2’s four symmetrical limbs can be used for a whole bunch of stuff. It can do quadrupedal walking and running, and it’s able to reach stable speeds of up to 1.5 m/s. If you want bipedal walking, it can do that NABiRoS-style, although it’s still a bit fragile at the moment. Using two legs for walking leaves two legs free, and those legs can turn into arms. A tripedal compromise configuration, with three legs and one arm, is more stable and allows the robot to do things like push buttons, open doors, and destroy property. And thanks to passive wheels under its body, ALPHRED 2 can use its limbs to quickly and efficiently skate around:

The impressive performance of the robot comes courtesy of a custom actuator that RoMeLa designed specifically for dynamic legged locomotion. They call it BEAR, or Back-Drivable Electromechanical Actuator for Robots. These are optionally liquid-cooled motors capable of proprioceptive sensing, consisting of a DC motor, a single stage 10:1 planetary gearbox, and channels through the back of the housing that coolant can be pumped through. The actuators have a peak torque of 32 Nm, and a continuous torque of about 8 Nm with passive air cooling. With liquid cooling, the continuous torque jumps to about 21 Nm. And in the videos above, ALPHRED 2 isn’t even running the liquid cooling system, suggesting that it’s capable of much higher sustained performance.

Photo: RoMeLa

Using two legs for walking leaves two legs free, and those legs can turn into arms.

RoMeLa has produced a bunch of very creative robots, and we appreciate that they also seem to produce a bunch of very creative demos showing why their unusual approaches are in fact (at least in some specific cases) somewhat practical. With the recent interest in highly dynamic robots that can be reliably useful in environments infested with humans, we can’t wait to see what kinds of exciting tricks the next (presumably liquid-cooled) version will be able to do.

[ RoMeLa ] Continue reading →

Posted in Human Robots

#435199 The Rise of AI Art—and What It Means ...

Posted on June 18, 2019 by Android

Artificially intelligent systems are slowly taking over tasks previously done by humans, and many processes involving repetitive, simple movements have already been fully automated. In the meantime, humans continue to be superior when it comes to abstract and creative tasks.

However, it seems like even when it comes to creativity, we’re now being challenged by our own creations.

In the last few years, we’ve seen the emergence of hundreds of “AI artists.” These complex algorithms are creating unique (and sometimes eerie) works of art. They’re generating stunning visuals, profound poetry, transcendent music, and even realistic movie scripts. The works of these AI artists are raising questions about the nature of art and the role of human creativity in future societies.

Here are a few works of art created by non-human entities.

Unsecured Futures
by Ai.Da

Ai-Da Robot with Painting. Image Credit: Ai-Da portraits by Nicky Johnston. Published with permission from Midas Public Relations.
Earlier this month we saw the announcement of Ai.Da, considered the first ultra-realistic drawing robot artist. Her mechanical abilities, combined with AI-based algorithms, allow her to draw, paint, and even sculpt. She is able to draw people using her artificial eye and a pencil in her hand. Ai.Da’s artwork and first solo exhibition, Unsecured Futures, will be showcased at Oxford University in July.

Ai-Da Cartesian Painting. Image Credit: Ai-Da Artworks. Published with permission from Midas Public Relations.
Obviously Ai.Da has no true consciousness, thoughts, or feelings. Despite that, the (human) organizers of the exhibition believe that Ai.Da serves as a basis for crucial conversations about the ethics of emerging technologies. The exhibition will serve as a stimulant for engaging with critical questions about what kind of future we ought to create via such technologies.

The exhibition’s creators wrote, “Humans are confident in their position as the most powerful species on the planet, but how far do we actually want to take this power? To a Brave New World (Nightmare)? And if we use new technologies to enhance the power of the few, we had better start safeguarding the future of the many.”

Google’s PoemPortraits
Our transcendence adorns,
That society of the stars seem to be the secret.

The two lines of poetry above aren’t like any poetry you’ve come across before. They are generated by an algorithm that was trained via deep learning neural networks trained on 20 million words of 19th-century poetry.

Google’s latest art project, named PoemPortraits, takes a word of your suggestion and generates a unique poem (once again, a collaboration of man and machine). You can even add a selfie in the final “PoemPortrait.” Artist Es Devlin, the project’s creator, explains that the AI “doesn’t copy or rework existing phrases, but uses its training material to build a complex statistical model. As a result, the algorithm generates original phrases emulating the style of what it’s been trained on.”

The generated poetry can sometimes be profound, and sometimes completely meaningless.But what makes the PoemPortraits project even more interesting is that it’s a collaborative project. All of the generated lines of poetry are combined to form a consistently growing collective poem, which you can view after your lines are generated. In many ways, the final collective poem is a collaboration of people from around the world working with algorithms.

Faceless Portraits Transcending Time
AICAN + Ahmed Elgammal

Image Credit: AICAN + Ahmed Elgammal | Faceless Portrait #2 (2019) | Artsy.
In March of this year, an AI artist called AICAN and its creator Ahmed Elgammal took over a New York gallery. The exhibition at HG Commentary showed two series of canvas works portraying harrowing, dream-like faceless portraits.

The exhibition was not simply credited to a machine, but rather attributed to the collaboration between a human and machine. Ahmed Elgammal is the founder and director of the Art and Artificial Intelligence Laboratory at Rutgers University. He considers AICAN to not only be an autonomous AI artist, but also a collaborator for artistic endeavors.

How did AICAN create these eerie faceless portraits? The system was presented with 100,000 photos of Western art from over five centuries, allowing it to learn the aesthetics of art via machine learning. It then drew from this historical knowledge and the mandate to create something new to create an artwork without human intervention.

Genesis
by AIVA Technologies

Listen to the score above. While you do, reflect on the fact that it was generated by an AI.

AIVA is an AI that composes soundtrack music for movies, commercials, games, and trailers. Its creative works span a wide range of emotions and moods. The scores it generates are indistinguishable from those created by the most talented human composers.

The AIVA music engine allows users to generate original scores in multiple ways. One is to upload an existing human-generated score and select the temp track to base the composition process on. Another method involves using preset algorithms to compose music in pre-defined styles, including everything from classical to Middle Eastern.

Currently, the platform is promoted as an opportunity for filmmakers and producers. But in the future, perhaps every individual will have personalized music generated for them based on their interests, tastes, and evolving moods. We already have algorithms on streaming websites recommending novel music to us based on our interests and history. Soon, algorithms may be used to generate music and other works of art that are tailored to impact our unique psyches.

The Future of Art: Pushing Our Creative Limitations
These works of art are just a glimpse into the breadth of the creative works being generated by algorithms and machines. Many of us will rightly fear these developments. We have to ask ourselves what our role will be in an era where machines are able to perform what we consider complex, abstract, creative tasks. The implications on the future of work, education, and human societies are profound.

At the same time, some of these works demonstrate that AI artists may not necessarily represent a threat to human artists, but rather an opportunity for us to push our creative boundaries. The most exciting artistic creations involve collaborations between humans and machines.

We have always used our technological scaffolding to push ourselves beyond our biological limitations. We use the telescope to extend our line of sight, planes to fly, and smartphones to connect with others. Our machines are not always working against us, but rather working as an extension of our minds. Similarly, we could use our machines to expand on our creativity and push the boundaries of art.

Image Credit: Ai-Da portraits by Nicky Johnston. Published with permission from Midas Public Relations. Continue reading →

Posted in Human Robots

#434792 Extending Human Longevity With ...

Posted on March 28, 2019 by Android

Lizards can regrow entire limbs. Flatworms, starfish, and sea cucumbers regrow entire bodies. Sharks constantly replace lost teeth, often growing over 20,000 teeth throughout their lifetimes. How can we translate these near-superpowers to humans?

The answer: through the cutting-edge innovations of regenerative medicine.

While big data and artificial intelligence transform how we practice medicine and invent new treatments, regenerative medicine is about replenishing, replacing, and rejuvenating our physical bodies.

In Part 5 of this blog series on Longevity and Vitality, I detail three of the regenerative technologies working together to fully augment our vital human organs.

Replenish: Stem cells, the regenerative engine of the body
Replace: Organ regeneration and bioprinting
Rejuvenate: Young blood and parabiosis

Let’s dive in.

Replenish: Stem Cells – The Regenerative Engine of the Body
Stem cells are undifferentiated cells that can transform into specialized cells such as heart, neurons, liver, lung, skin and so on, and can also divide to produce more stem cells.

In a child or young adult, these stem cells are in large supply, acting as a built-in repair system. They are often summoned to the site of damage or inflammation to repair and restore normal function.

But as we age, our supply of stem cells begins to diminish as much as 100- to 10,000-fold in different tissues and organs. In addition, stem cells undergo genetic mutations, which reduce their quality and effectiveness at renovating and repairing your body.

Imagine your stem cells as a team of repairmen in your newly constructed mansion. When the mansion is new and the repairmen are young, they can fix everything perfectly. But as the repairmen age and reduce in number, your mansion eventually goes into disrepair and finally crumbles.

What if you could restore and rejuvenate your stem cell population?

One option to accomplish this restoration and rejuvenation is to extract and concentrate your own autologous adult stem cells from places like your adipose (or fat) tissue or bone marrow.

These stem cells, however, are fewer in number and have undergone mutations (depending on your age) from their original ‘software code.’ Many scientists and physicians now prefer an alternative source, obtaining stem cells from the placenta or umbilical cord, the leftovers of birth.

These stem cells, available in large supply and expressing the undamaged software of a newborn, can be injected into joints or administered intravenously to rejuvenate and revitalize.

Think of these stem cells as chemical factories generating vital growth factors that can help to reduce inflammation, fight autoimmune disease, increase muscle mass, repair joints, and even revitalize skin and grow hair.

Over the last decade, the number of publications per year on stem cell-related research has increased 40x, and the stem cell market is expected to increase to $297 billion by 2022.

Rising research and development initiatives to develop therapeutic options for chronic diseases and growing demand for regenerative treatment options are the most significant drivers of this budding industry.

Biologists led by Kohji Nishida at Osaka University in Japan have discovered a new way to nurture and grow the tissues that make up the human eyeball. The scientists are able to grow retinas, corneas, the eye’s lens, and more, using only a small sample of adult skin.

In a Stanford study, seven of 18 stroke victims who agreed to stem cell treatments showed remarkable motor function improvements. This treatment could work for other neurodegenerative conditions such as Alzheimer’s, Parkinson’s, and ALS.

Doctors from the USC Neurorestoration Center and Keck Medicine of USC injected stem cells into the damaged cervical spine of a recently paralyzed 21-year-old man. Three months later, he showed dramatic improvement in sensation and movement of both arms.

In 2019, doctors in the U.K. cured a patient with HIV for the second time ever thanks to the efficacy of stem cells. After giving the cancer patient (who also had HIV) an allogeneic haematopoietic (e.g. blood) stem cell treatment for his Hodgkin’s lymphoma, the patient went into long-term HIV remission—18 months and counting at the time of the study’s publication.

Replace: Organ Regeneration and 3D Printing
Every 10 minutes, someone is added to the US organ transplant waiting list, totaling over 113,000 people waiting for replacement organs as of January 2019.

Countless more people in need of ‘spare parts’ never make it onto the waiting list. And on average, 20 people die each day while waiting for a transplant.

As a result, 35 percent of all US deaths (~900,000 people) could be prevented or delayed with access to organ replacements.

The excessive demand for donated organs will only intensify as technologies like self-driving cars make the world safer, given that many organ donors result from auto and motorcycle accidents. Safer vehicles mean less accidents and donations.

Clearly, replacement and regenerative medicine represent a massive opportunity.

Organ Entrepreneurs
Enter United Therapeutics CEO, Dr. Martine Rothblatt. A one-time aerospace entrepreneur (she was the founder of Sirius Satellite Radio), Rothblatt changed careers in the 1990s after her daughter developed a rare lung disease.

Her moonshot today is to create an industry of replacement organs. With an initial focus on diseases of the lung, Rothblatt set out to create replacement lungs. To accomplish this goal, her company United Therapeutics has pursued a number of technologies in parallel.

3D Printing Lungs
In 2017, United teamed up with one of the world’s largest 3D printing companies, 3D Systems, to build a collagen bioprinter and is paying another company, 3Scan, to slice up lungs and create detailed maps of their interior.

This 3D Systems bioprinter now operates according to a method called stereolithography. A UV laser flickers through a shallow pool of collagen doped with photosensitive molecules. Wherever the laser lingers, the collagen cures and becomes solid.

Gradually, the object being printed is lowered and new layers are added. The printer can currently lay down collagen at a resolution of around 20 micrometers, but will need to achieve resolution of a micrometer in size to make the lung functional.

Once a collagen lung scaffold has been printed, the next step is to infuse it with human cells, a process called recellularization.

The goal here is to use stem cells that grow on scaffolding and differentiate, ultimately providing the proper functionality. Early evidence indicates this approach can work.

In 2018, Harvard University experimental surgeon Harald Ott reported that he pumped billions of human cells (from umbilical cords and diced lungs) into a pig lung stripped of its own cells. When Ott’s team reconnected it to a pig’s circulation, the resulting organ showed rudimentary function.

Humanizing Pig Lungs
Another of Rothblatt’s organ manufacturing strategies is called xenotransplantation, the idea of transplanting an animal’s organs into humans who need a replacement.

Given the fact that adult pig organs are similar in size and shape to those of humans, United Therapeutics has focused on genetically engineering pigs to allow humans to use their organs. “It’s actually not rocket science,” said Rothblatt in her 2015 TED talk. “It’s editing one gene after another.”

To accomplish this goal, United Therapeutics made a series of investments in companies such as Revivicor Inc. and Synthetic Genomics Inc., and signed large funding agreements with the University of Maryland, University of Alabama, and New York Presbyterian/Columbia University Medical Center to create xenotransplantation programs for new hearts, kidneys, and lungs, respectively. Rothblatt hopes to see human translation in three to four years.

In preparation for that day, United Therapeutics owns a 132-acre property in Research Triangle Park and built a 275,000-square-foot medical laboratory that will ultimately have the capability to annually produce up to 1,000 sets of healthy pig lungs—known as xenolungs—from genetically engineered pigs.

Lung Ex Vivo Perfusion Systems
Beyond 3D printing and genetically engineering pig lungs, Rothblatt has already begun implementing a third near-term approach to improve the supply of lungs across the US.

Only about 30 percent of potential donor lungs meet transplant criteria in the first place; of those, only about 85 percent of those are usable once they arrive at the surgery center. As a result, nearly 75 percent of possible lungs never make it to the recipient in need.

What if these lungs could be rejuvenated? This concept informs Dr. Rothblatt’s next approach.

In 2016, United Therapeutics invested $41.8 million in TransMedics Inc., an Andover, Massachusetts company that develops ex vivo perfusion systems for donor lungs, hearts, and kidneys.

The XVIVO Perfusion System takes marginal-quality lungs that initially failed to meet transplantation standard-of-care criteria and perfuses and ventilates them at normothermic conditions, providing an opportunity for surgeons to reassess transplant suitability.

Rejuvenate Young Blood and Parabiosis
In HBO’s parody of the Bay Area tech community, Silicon Valley, one of the episodes (Season 4, Episode 5) is named “The Blood Boy.”

In this installment, tech billionaire Gavin Belson (Matt Ross) is meeting with Richard Hendricks (Thomas Middleditch) and his team, speaking about the future of the decentralized internet. A young, muscled twenty-something disrupts the meeting when he rolls in a transfusion stand and silently hooks an intravenous connection between himself and Belson.

Belson then introduces the newcomer as his “transfusion associate” and begins to explain the science of parabiosis: “Regular transfusions of the blood of a younger physically fit donor can significantly retard the aging process.”

While the sitcom is fiction, that science has merit, and the scenario portrayed in the episode is already happening today.

On the first point, research at Stanford and Harvard has demonstrated that older animals, when transfused with the blood of young animals, experience regeneration across many tissues and organs.

The opposite is also true: young animals, when transfused with the blood of older animals, experience accelerated aging. But capitalizing on this virtual fountain of youth has been tricky.

Ambrosia
One company, a San Francisco-based startup called Ambrosia, recently commenced one of the trials on parabiosis. Their protocol is simple: Healthy participants aged 35 and older get a transfusion of blood plasma from donors under 25, and researchers monitor their blood over the next two years for molecular indicators of health and aging.

Ambrosia’s founder Jesse Karmazin became interested in launching a company around parabiosis after seeing impressive data from animals and studies conducted abroad in humans: In one trial after another, subjects experience a reversal of aging symptoms across every major organ system. “The effects seem to be almost permanent,” he said. “It’s almost like there’s a resetting of gene expression.”

Infusing your own cord blood stem cells as you age may have tremendous longevity benefits. Following an FDA press release in February 2019, Ambrosia halted its consumer-facing treatment after several months of operation.

Understandably, the FDA raised concerns about the practice of parabiosis because to date, there is a marked lack of clinical data to support the treatment’s effectiveness.

Elevian
On the other end of the reputability spectrum is a startup called Elevian, spun out of Harvard University. Elevian is approaching longevity with a careful, scientifically validated strategy. (Full Disclosure: I am both an advisor to and investor in Elevian.)

CEO Mark Allen, MD, is joined by a dozen MDs and Ph.Ds out of Harvard. Elevian’s scientific founders started the company after identifying specific circulating factors that may be responsible for the “young blood” effect.

One example: A naturally occurring molecule known as “growth differentiation factor 11,” or GDF11, when injected into aged mice, reproduces many of the regenerative effects of young blood, regenerating heart, brain, muscles, lungs, and kidneys.

More specifically, GDF11 supplementation reduces age-related cardiac hypertrophy, accelerates skeletal muscle repair, improves exercise capacity, improves brain function and cerebral blood flow, and improves metabolism.

Elevian is developing a number of therapeutics that regulate GDF11 and other circulating factors. The goal is to restore our body’s natural regenerative capacity, which Elevian believes can address some of the root causes of age-associated disease with the promise of reversing or preventing many aging-related diseases and extending the healthy lifespan.

Conclusion
In 1992, futurist Leland Kaiser coined the term “regenerative medicine”:

“A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.”

Since then, the powerful regenerative medicine industry has grown exponentially, and this rapid growth is anticipated to continue.

A dramatic extension of the human healthspan is just over the horizon. Soon, we’ll all have the regenerative superpowers previously relegated to a handful of animals and comic books.

What new opportunities open up when anybody, anywhere, and at anytime can regenerate, replenish, and replace entire organs and metabolic systems on command?

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