Tag Archives: lab

#432027 We Read This 800-Page Report on the ...

The longevity field is bustling but still fragmented, and the “silver tsunami” is coming.

That is the takeaway of The Science of Longevity, the behemoth first volume of a four-part series offering a bird’s-eye view of the longevity industry in 2017. The report, a joint production of the Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International, synthesizes the growing array of academic and industry ventures related to aging, healthspan, and everything in between.

This is huge, not only in scale but also in ambition. The report, totally worth a read here, will be followed by four additional volumes in 2018, covering topics ranging from the business side of longevity ventures to financial systems to potential tensions between life extension and religion.

And that’s just the first step. The team hopes to publish updated versions of the report annually, giving scientists, investors, and regulatory agencies an easy way to keep their finger on the longevity pulse.

“In 2018, ‘aging’ remains an unnamed adversary in an undeclared war. For all intents and purposes it is mere abstraction in the eyes of regulatory authorities worldwide,” the authors write.

That needs to change.

People often arrive at the field of aging from disparate areas with wildly diverse opinions and strengths. The report compiles these individual efforts at cracking aging into a systematic resource—a “periodic table” for longevity that clearly lays out emerging trends and promising interventions.

The ultimate goal? A global framework serving as a road map to guide the burgeoning industry. With such a framework in hand, academics and industry alike are finally poised to petition the kind of large-scale investments and regulatory changes needed to tackle aging with a unified front.

Infographic depicting many of the key research hubs and non-profits within the field of geroscience.
Image Credit: Longevity.International
The Aging Globe
The global population is rapidly aging. And our medical and social systems aren’t ready to handle this oncoming “silver tsunami.”

Take the medical field. Many age-related diseases such as Alzheimer’s lack effective treatment options. Others, including high blood pressure, stroke, lung or heart problems, require continuous medication and monitoring, placing enormous strain on medical resources.

What’s more, because disease risk rises exponentially with age, medical care for the elderly becomes a game of whack-a-mole: curing any individual disease such as cancer only increases healthy lifespan by two to three years before another one hits.

That’s why in recent years there’s been increasing support for turning the focus to the root of the problem: aging. Rather than tackling individual diseases, geroscience aims to add healthy years to our lifespan—extending “healthspan,” so to speak.

Despite this relative consensus, the field still faces a roadblock. The US FDA does not yet recognize aging as a bona fide disease. Without such a designation, scientists are banned from testing potential interventions for aging in clinical trials (that said, many have used alternate measures such as age-related biomarkers or Alzheimer’s symptoms as a proxy).

Luckily, the FDA’s stance is set to change. The promising anti-aging drug metformin, for example, is already in clinical trials, examining its effect on a variety of age-related symptoms and diseases. This report, and others to follow, may help push progress along.

“It is critical for investors, policymakers, scientists, NGOs, and influential entities to prioritize the amelioration of the geriatric world scenario and recognize aging as a critical matter of global economic security,” the authors say.

Biomedical Gerontology
The causes of aging are complex, stubborn, and not all clear.

But the report lays out two main streams of intervention with already promising results.

The first is to understand the root causes of aging and stop them before damage accumulates. It’s like meddling with cogs and other inner workings of a clock to slow it down, the authors say.

The report lays out several treatments to keep an eye on.

Geroprotective drugs is a big one. Often repurposed from drugs already on the market, these traditional small molecule drugs target a wide variety of metabolic pathways that play a role in aging. Think anti-oxidants, anti-inflammatory, and drugs that mimic caloric restriction, a proven way to extend healthspan in animal models.

More exciting are the emerging technologies. One is nanotechnology. Nanoparticles of carbon, “bucky-balls,” for example, have already been shown to fight viral infections and dangerous ion particles, as well as stimulate the immune system and extend lifespan in mice (though others question the validity of the results).

Blood is another promising, if surprising, fountain of youth: recent studies found that molecules in the blood of the young rejuvenate the heart, brain, and muscles of aged rodents, though many of these findings have yet to be replicated.

Rejuvenation Biotechnology
The second approach is repair and maintenance.

Rather than meddling with inner clockwork, here we force back the hands of a clock to set it back. The main example? Stem cell therapy.

This type of approach would especially benefit the brain, which harbors small, scattered numbers of stem cells that deplete with age. For neurodegenerative diseases like Alzheimer’s, in which neurons progressively die off, stem cell therapy could in theory replace those lost cells and mend those broken circuits.

Once a blue-sky idea, the discovery of induced pluripotent stem cells (iPSCs), where scientists can turn skin and other mature cells back into a stem-like state, hugely propelled the field into near reality. But to date, stem cells haven’t been widely adopted in clinics.

It’s “a toolkit of highly innovative, highly invasive technologies with clinical trials still a great many years off,” the authors say.

But there is a silver lining. The boom in 3D tissue printing offers an alternative approach to stem cells in replacing aging organs. Recent investment from the Methuselah Foundation and other institutions suggests interest remains high despite still being a ways from mainstream use.

A Disruptive Future
“We are finally beginning to see an industry emerge from mankind’s attempts to make sense of the biological chaos,” the authors conclude.

Looking through the trends, they identified several technologies rapidly gaining steam.

One is artificial intelligence, which is already used to bolster drug discovery. Machine learning may also help identify new longevity genes or bring personalized medicine to the clinic based on a patient’s records or biomarkers.

Another is senolytics, a class of drugs that kill off “zombie cells.” Over 10 prospective candidates are already in the pipeline, with some expected to enter the market in less than a decade, the authors say.

Finally, there’s the big gun—gene therapy. The treatment, unlike others mentioned, can directly target the root of any pathology. With a snip (or a swap), genetic tools can turn off damaging genes or switch on ones that promote a youthful profile. It is the most preventative technology at our disposal.

There have already been some success stories in animal models. Using gene therapy, rodents given a boost in telomerase activity, which lengthens the protective caps of DNA strands, live healthier for longer.

“Although it is the prospect farthest from widespread implementation, it may ultimately prove the most influential,” the authors say.

Ultimately, can we stop the silver tsunami before it strikes?

Perhaps not, the authors say. But we do have defenses: the technologies outlined in the report, though still immature, could one day stop the oncoming tidal wave in its tracks.

Now we just have to bring them out of the lab and into the real world. To push the transition along, the team launched Longevity.International, an online meeting ground that unites various stakeholders in the industry.

By providing scientists, entrepreneurs, investors, and policy-makers a platform for learning and discussion, the authors say, we may finally generate enough drive to implement our defenses against aging. The war has begun.

Read the report in full here, and watch out for others coming soon here. The second part of the report profiles 650 (!!!) longevity-focused research hubs, non-profits, scientists, conferences, and literature. It’s an enormously helpful resource—totally worth keeping it in your back pocket for future reference.

Image Credit: Worraket / Shutterstock.com Continue reading

Posted in Human Robots

#431906 Low-Cost Soft Robot Muscles Can Lift 200 ...

Jerky mechanical robots are staples of science fiction, but to seamlessly integrate into everyday life they’ll need the precise yet powerful motor control of humans. Now scientists have created a new class of artificial muscles that could soon make that a reality.
The advance is the latest breakthrough in the field of soft robotics. Scientists are increasingly designing robots using soft materials that more closely resemble biological systems, which can be more adaptable and better suited to working in close proximity to humans.
One of the main challenges has been creating soft components that match the power and control of the rigid actuators that drive mechanical robots—things like motors and pistons. Now researchers at the University of Colorado Boulder have built a series of low-cost artificial muscles—as little as 10 cents per device—using soft plastic pouches filled with electrically insulating liquids that contract with the force and speed of mammalian skeletal muscles when a voltage is applied to them.

Three different designs of the so-called hydraulically amplified self-healing electrostatic (HASEL) actuators were detailed in two papers in the journals Science and Science Robotics last week. They could carry out a variety of tasks, from gently picking up delicate objects like eggs or raspberries to lifting objects many times their own weight, such as a gallon of water, at rapid repetition rates.
“We draw our inspiration from the astonishing capabilities of biological muscle,” Christoph Keplinger, an assistant professor at UC Boulder and senior author of both papers, said in a press release. “Just like biological muscle, HASEL actuators can reproduce the adaptability of an octopus arm, the speed of a hummingbird and the strength of an elephant.”
The artificial muscles work by applying a voltage to hydrogel electrodes on either side of pouches filled with liquid insulators, which can be as simple as canola oil. This creates an attraction between the two electrodes, pulling them together and displacing the liquid. This causes a change of shape that can push or pull levers, arms or any other articulated component.
The design is essentially a synthesis of two leading approaches to actuating soft robots. Pneumatic and hydraulic actuators that pump fluids around have been popular due to their high forces, easy fabrication and ability to mimic a variety of natural motions. But they tend to be bulky and relatively slow.
Dielectric elastomer actuators apply an electric field across a solid insulating layer to make it flex. These can mimic the responsiveness of biological muscle. But they are not very versatile and can also fail catastrophically, because the high voltages required can cause a bolt of electricity to blast through the insulator, destroying it. The likelihood of this happening increases in line with the size of their electrodes, which makes it hard to scale them up. By combining the two approaches, researchers get the best of both worlds, with the power, versatility and easy fabrication of a fluid-based system and the responsiveness of electrically-powered actuators.
One of the designs holds particular promise for robotics applications, as it behaves a lot like biological muscle. The so-called Peano-HASEL actuators are made up of multiple rectangular pouches connected in series, which allows them to contract linearly, just like real muscle. They can lift more than 200 times their weight, but being electrically powered, they exceed the flexing speed of human muscle.
As the name suggests, the HASEL actuators are also self-healing. They are still prone to the same kind of electrical damage as dielectric elastomer actuators, but the liquid insulator is able to immediately self-heal by redistributing itself and regaining its insulating properties.
The muscles can even monitor the amount of strain they’re under to provide the same kind of feedback biological systems would. The muscle’s capacitance—its ability to store an electric charge—changes as the device stretches, which makes it possible to power the arm while simultaneously measuring what position it’s in.
The researchers say this could imbue robots with a similar sense of proprioception or body-awareness to that found in plants and animals. “Self-sensing allows for the development of closed-loop feedback controllers to design highly advanced and precise robots for diverse applications,” Shane Mitchell, a PhD student in Keplinger’s lab and an author on both papers, said in an email.
The researchers say the high voltages required are an ongoing challenge, though they’ve already designed devices in the lab that use a fifth of the voltage of those features in the recent papers.
In most of their demonstrations, these soft actuators were being used to power rigid arms and levers, pointing to the fact that future robots are likely to combine both rigid and soft components, much like animals do. The potential applications for the technology range from more realistic prosthetics to much more dextrous robots that can work easily alongside humans.
It will take some work before these devices appear in commercial robots. But the combination of high-performance with simple and inexpensive fabrication methods mean other researchers are likely to jump in, so innovation could be rapid.
Image Credit: Keplinger Research Group/University of Colorado Continue reading

Posted in Human Robots

#431872 AI Uses Titan Supercomputer to Create ...

You don’t have to dig too deeply into the archive of dystopian science fiction to uncover the horror that intelligent machines might unleash. The Matrix and The Terminator are probably the most well-known examples of self-replicating, intelligent machines attempting to enslave or destroy humanity in the process of building a brave new digital world.
The prospect of artificially intelligent machines creating other artificially intelligent machines took a big step forward in 2017. However, we’re far from the runaway technological singularity futurists are predicting by mid-century or earlier, let alone murderous cyborgs or AI avatar assassins.
The first big boost this year came from Google. The tech giant announced it was developing automated machine learning (AutoML), writing algorithms that can do some of the heavy lifting by identifying the right neural networks for a specific job. Now researchers at the Department of Energy’s Oak Ridge National Laboratory (ORNL), using the most powerful supercomputer in the US, have developed an AI system that can generate neural networks as good if not better than any developed by a human in less than a day.
It can take months for the brainiest, best-paid data scientists to develop deep learning software, which sends data through a complex web of mathematical algorithms. The system is modeled after the human brain and known as an artificial neural network. Even Google’s AutoML took weeks to design a superior image recognition system, one of the more standard operations for AI systems today.
Computing Power
Of course, Google Brain project engineers only had access to 800 graphic processing units (GPUs), a type of computer hardware that works especially well for deep learning. Nvidia, which pioneered the development of GPUs, is considered the gold standard in today’s AI hardware architecture. Titan, the supercomputer at ORNL, boasts more than 18,000 GPUs.
The ORNL research team’s algorithm, called MENNDL for Multinode Evolutionary Neural Networks for Deep Learning, isn’t designed to create AI systems that cull cute cat photos from the internet. Instead, MENNDL is a tool for testing and training thousands of potential neural networks to work on unique science problems.
That requires a different approach from the Google and Facebook AI platforms of the world, notes Steven Young, a postdoctoral research associate at ORNL who is on the team that designed MENNDL.
“We’ve discovered that those [neural networks] are very often not the optimal network for a lot of our problems, because our data, while it can be thought of as images, is different,” he explains to Singularity Hub. “These images, and the problems, have very different characteristics from object detection.”
AI for Science
One application of the technology involved a particle physics experiment at the Fermi National Accelerator Laboratory. Fermilab researchers are interested in understanding neutrinos, high-energy subatomic particles that rarely interact with normal matter but could be a key to understanding the early formation of the universe. One Fermilab experiment involves taking a sort of “snapshot” of neutrino interactions.
The team wanted the help of an AI system that could analyze and classify Fermilab’s detector data. MENNDL evaluated 500,000 neural networks in 24 hours. Its final solution proved superior to custom models developed by human scientists.
In another case involving a collaboration with St. Jude Children’s Research Hospital in Memphis, MENNDL improved the error rate of a human-designed algorithm for identifying mitochondria inside 3D electron microscopy images of brain tissue by 30 percent.
“We are able to do better than humans in a fraction of the time at designing networks for these sort of very different datasets that we’re interested in,” Young says.
What makes MENNDL particularly adept is its ability to define the best or most optimal hyperparameters—the key variables—to tackle a particular dataset.
“You don’t always need a big, huge deep network. Sometimes you just need a small network with the right hyperparameters,” Young says.
A Virtual Data Scientist
That’s not dissimilar to the approach of a company called H20.ai, a startup out of Silicon Valley that uses open source machine learning platforms to “democratize” AI. It applies machine learning to create business solutions for Fortune 500 companies, including some of the world’s biggest banks and healthcare companies.
“Our software is more [about] pattern detection, let’s say anti-money laundering or fraud detection or which customer is most likely to churn,” Dr. Arno Candel, chief technology officer at H2O.ai, tells Singularity Hub. “And that kind of insight-generating software is what we call AI here.”
The company’s latest product, Driverless AI, promises to deliver the data scientist equivalent of a chessmaster to its customers (the company claims several such grandmasters in its employ and advisory board). In other words, the system can analyze a raw dataset and, like MENNDL, automatically identify what features should be included in the computer model to make the most of the data based on the best “chess moves” of its grandmasters.
“So we’re using those algorithms, but we’re giving them the human insights from those data scientists, and we automate their thinking,” he explains. “So we created a virtual data scientist that is relentless at trying these ideas.”
Inside the Black Box
Not unlike how the human brain reaches a conclusion, it’s not always possible to understand how a machine, despite being designed by humans, reaches its own solutions. The lack of transparency is often referred to as the AI “black box.” Experts like Young say we can learn something about the evolutionary process of machine learning by generating millions of neural networks and seeing what works well and what doesn’t.
“You’re never going to be able to completely explain what happened, but maybe we can better explain it than we currently can today,” Young says.
Transparency is built into the “thought process” of each particular model generated by Driverless AI, according to Candel.
The computer even explains itself to the user in plain English at each decision point. There is also real-time feedback that allows users to prioritize features, or parameters, to see how the changes improve the accuracy of the model. For example, the system may include data from people in the same zip code as it creates a model to describe customer turnover.
“That’s one of the advantages of our automatic feature engineering: it’s basically mimicking human thinking,” Candel says. “It’s not just neural nets that magically come up with some kind of number, but we’re trying to make it statistically significant.”
Moving Forward
Much digital ink has been spilled over the dearth of skilled data scientists, so automating certain design aspects for developing artificial neural networks makes sense. Experts agree that automation alone won’t solve that particular problem. However, it will free computer scientists to tackle more difficult issues, such as parsing the inherent biases that exist within the data used by machine learning today.
“I think the world has an opportunity to focus more on the meaning of things and not on the laborious tasks of just fitting a model and finding the best features to make that model,” Candel notes. “By automating, we are pushing the burden back for the data scientists to actually do something more meaningful, which is think about the problem and see how you can address it differently to make an even bigger impact.”
The team at ORNL expects it can also make bigger impacts beginning next year when the lab’s next supercomputer, Summit, comes online. While Summit will boast only 4,600 nodes, it will sport the latest and greatest GPU technology from Nvidia and CPUs from IBM. That means it will deliver more than five times the computational performance of Titan, the world’s fifth-most powerful supercomputer today.
“We’ll be able to look at much larger problems on Summit than we were able to with Titan and hopefully get to a solution much faster,” Young says.
It’s all in a day’s work.
Image Credit: Gennady Danilkin / Shutterstock.com Continue reading

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#431690 Oxford Study Says Alien Life Would ...

The alternative universe known as science fiction has given our culture a menagerie of alien species. From overstuffed teddy bears like Ewoks and Wookies to terrifying nightmares such as Alien and Predator, our collective imagination of what form alien life from another world may take has been irrevocably imprinted by Hollywood.
It might all be possible, or all these bug-eyed critters might turn out to be just B-movie versions of how real extraterrestrials will appear if and when they finally make the evening news.
One thing for certain is that aliens from another world will be shaped by the same evolutionary forces as here on Earth—natural selection. That’s the conclusion of a team of scientists from the University of Oxford in a study published this month in the International Journal of Astrobiology.
A complex alien that comprises a hierarchy of entities, where each lower level collection of entities has aligned evolutionary interests.Image Credit: Helen S. Cooper/University of Oxford.
The researchers suggest that evolutionary theory—famously put forth by Charles Darwin in his seminal book On the Origin of Species 158 years ago this month—can be used to make some predictions about alien species. In particular, the team argues that extraterrestrials will undergo natural selection, because that is the only process by which organisms can adapt to their environment.
“Adaptation is what defines life,” lead author Samuel Levin tells Singularity Hub.
While it’s likely that NASA or some SpaceX-like private venture will eventually kick over a few space rocks and discover microbial life in the not-too-distant future, the sorts of aliens Levin and his colleagues are interested in describing are more complex. That’s because natural selection is at work.
A quick evolutionary theory 101 refresher: Natural selection is the process by which certain traits are favored over others in a given population. For example, take a group of brown and green beetles. It just so happens that birds prefer foraging on green beetles, allowing more brown beetles to survive and reproduce than the more delectable green ones. Eventually, if these population pressures persist, brown beetles will become the dominant type. Brown wins, green loses.
And just as human beings are the result of millions of years of adaptations—eyes and thumbs, for example—aliens will similarly be constructed from parts that were once free living but through time came together to work as one organism.
“Life has so many intricate parts, so much complexity, for that to happen (randomly),” Levin explains. “It’s too complex and too many things working together in a purposeful way for that to happen by chance, as how certain molecules come about. Instead you need a process for making it, and natural selection is that process.”
Just don’t expect ET to show up as a bipedal humanoid with a large head and almond-shaped eyes, Levin says.
“They can be built from entirely different chemicals and so visually, superficially, unfamiliar,” he explains. “They will have passed through the same evolutionary history as us. To me, that’s way cooler and more exciting than them having two legs.”
Need for Data
Seth Shostak, a lead astronomer at the SETI Institute and host of the organization’s Big Picture Science radio show, wrote that while the argument is interesting, it doesn’t answer the question of ET’s appearance.
Shostak argues that a more productive approach would invoke convergent evolution, where similar environments lead to similar adaptations, at least assuming a range of Earth-like conditions such as liquid oceans and thick atmospheres. For example, an alien species that evolved in a liquid environment would evolve a streamlined body to move through water.
“Happenstance and the specifics of the environment will produce variations on an alien species’ planet as it has on ours, and there’s really no way to predict these,” Shostak concludes. “Alas, an accurate cosmic bestiary cannot be written by the invocation of biological mechanisms alone. We need data. That requires more than simply thinking about alien life. We need to actually discover it.”
Search Is On
The search is on. On one hand, the task seems easy enough: There are at least 100 billion planets in the Milky Way alone, and at least 20 percent of those are likely to be capable of producing a biosphere. Even if the evolution of life is exceedingly rare—take a conservative estimate of .001 percent or 200,000 planets, as proposed by the Oxford paper—you have to like the odds.
Of course, it’s not that easy by a billion light years.
Planet hunters can’t even agree on what signatures of life they should focus on. The idea is that where there’s smoke there’s fire. In the case of an alien world home to biological life, astrobiologists are searching for the presence of “biosignature gases,” vapors that could only be produced by alien life.
As Quanta Magazine reported, scientists do this by measuring a planet’s atmosphere against starlight. Gases in the atmosphere absorb certain frequencies of starlight, offering a clue as to what is brewing around a particular planet.
The presence of oxygen would seem to be a biological no-brainer, but there are instances where a planet can produce a false positive, meaning non-biological processes are responsible for the exoplanet’s oxygen. Scientists like Sara Seager, an astrophysicist at MIT, have argued there are plenty of examples of other types of gases produced by organisms right here on Earth that could also produce the smoking gun, er, planet.

Life as We Know It
Indeed, the existence of Earth-bound extremophiles—organisms that defy conventional wisdom about where life can exist, such as in the vacuum of space—offer another clue as to what kind of aliens we might eventually meet.
Lynn Rothschild, an astrobiologist and synthetic biologist in the Earth Science Division at NASA’s Ames Research Center in Silicon Valley, takes extremophiles as a baseline and then supersizes them through synthetic biology.
For example, say a bacteria is capable of surviving at 120 degrees Celsius. Rothschild’s lab might tweak an organism’s DNA to see if it could metabolize at 150 degrees. The idea, as she explains, is to expand the envelope for life without ever getting into a rocket ship.

While researchers may not always agree on the “where” and “how” and “what” of the search for extraterrestrial life, most do share one belief: Alien life must be out there.
“It would shock me if there weren’t [extraterrestrials],” Levin says. “There are few things that would shock me more than to find out there aren’t any aliens…If I had to bet on it, I would bet on the side of there being lots and lots of aliens out there.”
Image Credit: NASA Continue reading

Posted in Human Robots

#431682 Oxford Study Says Alien Life Would ...

The alternative universe known as science fiction has given our culture a menagerie of alien species. From overstuffed teddy bears like Ewoks and Wookies to terrifying nightmares such as Alien and Predator, our collective imagination of what form alien life from another world may take has been irrevocably imprinted by Hollywood.
It might all be possible, or all these bug-eyed critters might turn out to be just B-movie versions of how real extraterrestrials will appear if and when they finally make the evening news.
One thing for certain is that aliens from another world will be shaped by the same evolutionary forces as here on Earth—natural selection. That’s the conclusion of a team of scientists from the University of Oxford in a study published this month in the International Journal of Astrobiology.
A complex alien that comprises a hierarchy of entities, where each lower level collection of entities has aligned evolutionary interests.Image Credit: Helen S. Cooper/University of Oxford.
The researchers suggest that evolutionary theory—famously put forth by Charles Darwin in his seminal book On the Origin of Species 158 years ago this month—can be used to make some predictions about alien species. In particular, the team argues that extraterrestrials will undergo natural selection, because that is the only process by which organisms can adapt to their environment.
“Adaptation is what defines life,” lead author Samuel Levin tells Singularity Hub.
While it’s likely that NASA or some SpaceX-like private venture will eventually kick over a few space rocks and discover microbial life in the not-too-distant future, the sorts of aliens Levin and his colleagues are interested in describing are more complex. That’s because natural selection is at work.
A quick evolutionary theory 101 refresher: Natural selection is the process by which certain traits are favored over others in a given population. For example, take a group of brown and green beetles. It just so happens that birds prefer foraging on green beetles, allowing more brown beetles to survive and reproduce than the more delectable green ones. Eventually, if these population pressures persist, brown beetles will become the dominant type. Brown wins, green loses.
And just as human beings are the result of millions of years of adaptations—eyes and thumbs, for example—aliens will similarly be constructed from parts that were once free living but through time came together to work as one organism.
“Life has so many intricate parts, so much complexity, for that to happen (randomly),” Levin explains. “It’s too complex and too many things working together in a purposeful way for that to happen by chance, as how certain molecules come about. Instead you need a process for making it, and natural selection is that process.”
Just don’t expect ET to show up as a bipedal humanoid with a large head and almond-shaped eyes, Levin says.
“They can be built from entirely different chemicals and so visually, superficially, unfamiliar,” he explains. “They will have passed through the same evolutionary history as us. To me, that’s way cooler and more exciting than them having two legs.”
Need for Data
Seth Shostak, a lead astronomer at the SETI Institute and host of the organization’s Big Picture Science radio show, wrote that while the argument is interesting, it doesn’t answer the question of ET’s appearance.
Shostak argues that a more productive approach would invoke convergent evolution, where similar environments lead to similar adaptations, at least assuming a range of Earth-like conditions such as liquid oceans and thick atmospheres. For example, an alien species that evolved in a liquid environment would evolve a streamlined body to move through water.
“Happenstance and the specifics of the environment will produce variations on an alien species’ planet as it has on ours, and there’s really no way to predict these,” Shostak concludes. “Alas, an accurate cosmic bestiary cannot be written by the invocation of biological mechanisms alone. We need data. That requires more than simply thinking about alien life. We need to actually discover it.”
Search is On
The search is on. On one hand, the task seems easy enough: There are at least 100 billion planets in the Milky Way alone, and at least 20 percent of those are likely to be capable of producing a biosphere. Even if the evolution of life is exceedingly rare—take a conservative estimate of .001 percent or 200,000 planets, as proposed by the Oxford paper—you have to like the odds.
Of course, it’s not that easy by a billion light years.
Planet hunters can’t even agree on what signatures of life they should focus on. The idea is that where there’s smoke there’s fire. In the case of an alien world home to biological life, astrobiologists are searching for the presence of “biosignature gases,” vapors that could only be produced by alien life.
As Quanta Magazine reported, scientists do this by measuring a planet’s atmosphere against starlight. Gases in the atmosphere absorb certain frequencies of starlight, offering a clue as to what is brewing around a particular planet.
The presence of oxygen would seem to be a biological no-brainer, but there are instances where a planet can produce a false positive, meaning non-biological processes are responsible for the exoplanet’s oxygen. Scientists like Sara Seager, an astrophysicist at MIT, have argued there are plenty of examples of other types of gases produced by organisms right here on Earth that could also produce the smoking gun, er, planet.

Life as We Know It
Indeed, the existence of Earth-bound extremophiles—organisms that defy conventional wisdom about where life can exist, such as in the vacuum of space—offer another clue as to what kind of aliens we might eventually meet.
Lynn Rothschild, an astrobiologist and synthetic biologist in the Earth Science Division at NASA’s Ames Research Center in Silicon Valley, takes extremophiles as a baseline and then supersizes them through synthetic biology.
For example, say a bacteria is capable of surviving at 120 degrees Celsius. Rothschild’s lab might tweak an organism’s DNA to see if it could metabolize at 150 degrees. The idea, as she explains, is to expand the envelope for life without ever getting into a rocket ship.

While researchers may not always agree on the “where” and “how” and “what” of the search for extraterrestrial life, most do share one belief: Alien life must be out there.
“It would shock me if there weren’t [extraterrestrials],” Levin says. “There are few things that would shock me more than to find out there aren’t any aliens…If I had to bet on it, I would bet on the side of there being lots and lots of aliens out there.”
Image Credit: NASA Continue reading

Posted in Human Robots