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#435080 12 Ways Big Tech Can Take Big Action on ...
Bill Gates and Mark Zuckerberg have invested $1 billion in Breakthrough Energy to fund next-generation solutions to tackle climate. But there is a huge risk that any successful innovation will only reach the market as the world approaches 2030 at the earliest.
We now know that reducing the risk of dangerous climate change means halving global greenhouse gas emissions by that date—in just 11 years. Perhaps Gates, Zuckerberg, and all the tech giants should invest equally in innovations to do with how their own platforms —search, social media, eCommerce—can support societal behavior changes to drive down emissions.
After all, the tech giants influence the decisions of four billion consumers every day. It is time for a social contract between tech and society.
Recently myself and collaborator Johan Falk published a report during the World Economic Forum in Davos outlining 12 ways the tech sector can contribute to supporting societal goals to stabilize Earth’s climate.
Become genuine climate guardians
Tech giants go to great lengths to show how serious they are about reducing their emissions. But I smell cognitive dissonance. Google and Microsoft are working in partnership with oil companies to develop AI tools to help maximize oil recovery. This is not the behavior of companies working flat-out to stabilize Earth’s climate. Indeed, few major tech firms have visions that indicate a stable and resilient planet might be a good goal, yet AI alone has the potential to slash greenhouse gas emissions by four percent by 2030—equivalent to the emissions of Australia, Canada, and Japan combined.
We are now developing a playbook, which we plan to publish later this year at the UN climate summit, about making it as simple as possible for a CEO to become a climate guardian.
Hey Alexa, do you care about the stability of Earth’s climate?
Increasingly, consumers are delegating their decisions to narrow artificial intelligence like Alexa and Siri. Welcome to a world of zero-click purchases.
Should algorithms and information architecture be designed to nudge consumer behavior towards low-carbon choices, for example by making these options the default? We think so. People don’t mind being nudged; in fact, they welcome efforts to make their lives better. For instance, if I want to lose weight, I know I will need all the help I can get. Let’s ‘nudge for good’ and experiment with supporting societal goals.
Use social media for good
Facebook’s goal is to bring the world closer together. With 2.2 billion users on the platform, CEO Mark Zuckerberg can reasonably claim this goal is possible. But social media has changed the flow of information in the world, creating a lucrative industry around a toxic brown-cloud of confusion and anger, with frankly terrifying implications for democracy. This has been linked to the rise of nationalism and populism, and to the election of leaders who shun international cooperation, dismiss scientific knowledge, and reverse climate action at a moment when we need it more than ever.
Social media tools need re-engineering to help people make sense of the world, support democratic processes, and build communities around societal goals. Make this your mission.
Design for a future on Earth
Almost everything is designed with computer software, from buildings to mobile phones to consumer packaging. It is time to make zero-carbon design the new default and design products for sharing, re-use and disassembly.
The future is circular
Halving emissions in a decade will require all companies to adopt circular business models to reduce material use. Some tech companies are leading the charge. Apple has committed to becoming 100 percent circular as soon as possible. Great.
While big tech companies strive to be market leaders here, many other companies lack essential knowledge. Tech companies can support rapid adoption in different economic sectors, not least because they have the know-how to scale innovations exponentially. It makes business sense. If economies of scale drive the price of recycled steel and aluminium down, everyone wins.
Reward low-carbon consumption
eCommerce platforms can create incentives for low-carbon consumption. The world’s largest experiment in greening consumer behavior is Ant Forest, set up by Chinese fintech giant Ant Financial.
An estimated 300 million customers—similar to the population of the United States—gain points for making low-carbon choices such as walking to work, using public transport, or paying bills online. Virtual points are eventually converted into real trees. Sure, big questions remain about its true influence on emissions, but this is a space for rapid experimentation for big impact.
Make information more useful
Science is our tool for defining reality. Scientific consensus is how we attain reliable knowledge. Even after the information revolution, reliable knowledge about the world remains fragmented and unstructured. Build the next generation of search engines to genuinely make the world’s knowledge useful for supporting societal goals.
We need to put these tools towards supporting shared world views of the state of the planet based on the best science. New AI tools being developed by startups like Iris.ai can help see through the fog. From Alexa to Google Home and Siri, the future is “Voice”, but who chooses the information source? The highest bidder? Again, the implications for climate are huge.
Create new standards for digital advertising and marketing
Half of global ad revenue will soon be online, and largely going to a small handful of companies. How about creating a novel ethical standard on what is advertised and where? Companies could consider promoting sustainable choices and healthy lifestyles and limiting advertising of high-emissions products such as cheap flights.
We are what we eat
It is no secret that tech is about to disrupt grocery. The supermarkets of the future will be built on personal consumer data. With about two billion people either obese or overweight, revolutions in choice architecture could support positive diet choices, reduce meat consumption, halve food waste and, into the bargain, slash greenhouse gas emissions.
The future of transport is not cars, it’s data
The 2020s look set to be the biggest disruption of the automobile industry since Henry Ford unveiled the Model T. Two seismic shifts are on their way.
First, electric cars now compete favorably with petrol engines on range. Growth will reach an inflection point within a year or two once prices reach parity. The death of the internal combustion engine in Europe and Asia is assured with end dates announced by China, India, France, the UK, and most of Scandinavia. Dates range from 2025 (Norway) to 2040 (UK and China).
Tech giants can accelerate the demise. Uber recently announced a passenger surcharge to help London drivers save around $1,500 a year towards the cost of an electric car.
Second, driverless cars can shift the transport economic model from ownership to service and ride sharing. A complete shift away from privately-owned vehicles is around the corner, with large implications for emissions.
Clean-energy living and working
Most buildings are barely used and inefficiently heated and cooled. Digitization can slash this waste and its corresponding emissions through measurement, monitoring, and new business models to use office space. While, just a few unicorns are currently in this space, the potential is enormous. Buildings are one of the five biggest sources of emissions, yet have the potential to become clean energy producers in a distributed energy network.
Creating liveable cities
More cities are setting ambitious climate targets to halve emissions in a decade or even less. Tech companies can support this transition by driving demand for low-carbon services for their workforces and offices, but also by providing tools to help monitor emissions and act to reduce them. Google, for example, is collecting travel and other data from across cities to estimate emissions in real time. This is possible through technologies like artificial intelligence and the internet of things. But beware of smart cities that turn out to be not so smart. Efficiencies can reduce resilience when cities face crises.
It’s a Start
Of course, it will take more than tech to solve the climate crisis. But tech is a wildcard. The actions of the current tech giants and their acolytes could serve to destabilize the climate further or bring it under control.
We need a new social contract between tech companies and society to achieve societal goals. The alternative is unthinkable. Without drastic action now, climate chaos threatens to engulf us all. As this future approaches, regulators will be forced to take ever more draconian action to rein in the problem. Acting now will reduce that risk.
Note: A version of this article was originally published on World Economic Forum
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#434816 Untold History of AI: The DARPA Dreamer ...
J.C.R. Licklider's proposals for “man-machine symbiosis” led to the invention of the internet Continue reading
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#434792 Extending Human Longevity With ...
Lizards can regrow entire limbs. Flatworms, starfish, and sea cucumbers regrow entire bodies. Sharks constantly replace lost teeth, often growing over 20,000 teeth throughout their lifetimes. How can we translate these near-superpowers to humans?
The answer: through the cutting-edge innovations of regenerative medicine.
While big data and artificial intelligence transform how we practice medicine and invent new treatments, regenerative medicine is about replenishing, replacing, and rejuvenating our physical bodies.
In Part 5 of this blog series on Longevity and Vitality, I detail three of the regenerative technologies working together to fully augment our vital human organs.
Replenish: Stem cells, the regenerative engine of the body
Replace: Organ regeneration and bioprinting
Rejuvenate: Young blood and parabiosis
Let’s dive in.
Replenish: Stem Cells – The Regenerative Engine of the Body
Stem cells are undifferentiated cells that can transform into specialized cells such as heart, neurons, liver, lung, skin and so on, and can also divide to produce more stem cells.
In a child or young adult, these stem cells are in large supply, acting as a built-in repair system. They are often summoned to the site of damage or inflammation to repair and restore normal function.
But as we age, our supply of stem cells begins to diminish as much as 100- to 10,000-fold in different tissues and organs. In addition, stem cells undergo genetic mutations, which reduce their quality and effectiveness at renovating and repairing your body.
Imagine your stem cells as a team of repairmen in your newly constructed mansion. When the mansion is new and the repairmen are young, they can fix everything perfectly. But as the repairmen age and reduce in number, your mansion eventually goes into disrepair and finally crumbles.
What if you could restore and rejuvenate your stem cell population?
One option to accomplish this restoration and rejuvenation is to extract and concentrate your own autologous adult stem cells from places like your adipose (or fat) tissue or bone marrow.
These stem cells, however, are fewer in number and have undergone mutations (depending on your age) from their original ‘software code.’ Many scientists and physicians now prefer an alternative source, obtaining stem cells from the placenta or umbilical cord, the leftovers of birth.
These stem cells, available in large supply and expressing the undamaged software of a newborn, can be injected into joints or administered intravenously to rejuvenate and revitalize.
Think of these stem cells as chemical factories generating vital growth factors that can help to reduce inflammation, fight autoimmune disease, increase muscle mass, repair joints, and even revitalize skin and grow hair.
Over the last decade, the number of publications per year on stem cell-related research has increased 40x, and the stem cell market is expected to increase to $297 billion by 2022.
Rising research and development initiatives to develop therapeutic options for chronic diseases and growing demand for regenerative treatment options are the most significant drivers of this budding industry.
Biologists led by Kohji Nishida at Osaka University in Japan have discovered a new way to nurture and grow the tissues that make up the human eyeball. The scientists are able to grow retinas, corneas, the eye’s lens, and more, using only a small sample of adult skin.
In a Stanford study, seven of 18 stroke victims who agreed to stem cell treatments showed remarkable motor function improvements. This treatment could work for other neurodegenerative conditions such as Alzheimer’s, Parkinson’s, and ALS.
Doctors from the USC Neurorestoration Center and Keck Medicine of USC injected stem cells into the damaged cervical spine of a recently paralyzed 21-year-old man. Three months later, he showed dramatic improvement in sensation and movement of both arms.
In 2019, doctors in the U.K. cured a patient with HIV for the second time ever thanks to the efficacy of stem cells. After giving the cancer patient (who also had HIV) an allogeneic haematopoietic (e.g. blood) stem cell treatment for his Hodgkin’s lymphoma, the patient went into long-term HIV remission—18 months and counting at the time of the study’s publication.
Replace: Organ Regeneration and 3D Printing
Every 10 minutes, someone is added to the US organ transplant waiting list, totaling over 113,000 people waiting for replacement organs as of January 2019.
Countless more people in need of ‘spare parts’ never make it onto the waiting list. And on average, 20 people die each day while waiting for a transplant.
As a result, 35 percent of all US deaths (~900,000 people) could be prevented or delayed with access to organ replacements.
The excessive demand for donated organs will only intensify as technologies like self-driving cars make the world safer, given that many organ donors result from auto and motorcycle accidents. Safer vehicles mean less accidents and donations.
Clearly, replacement and regenerative medicine represent a massive opportunity.
Organ Entrepreneurs
Enter United Therapeutics CEO, Dr. Martine Rothblatt. A one-time aerospace entrepreneur (she was the founder of Sirius Satellite Radio), Rothblatt changed careers in the 1990s after her daughter developed a rare lung disease.
Her moonshot today is to create an industry of replacement organs. With an initial focus on diseases of the lung, Rothblatt set out to create replacement lungs. To accomplish this goal, her company United Therapeutics has pursued a number of technologies in parallel.
3D Printing Lungs
In 2017, United teamed up with one of the world’s largest 3D printing companies, 3D Systems, to build a collagen bioprinter and is paying another company, 3Scan, to slice up lungs and create detailed maps of their interior.
This 3D Systems bioprinter now operates according to a method called stereolithography. A UV laser flickers through a shallow pool of collagen doped with photosensitive molecules. Wherever the laser lingers, the collagen cures and becomes solid.
Gradually, the object being printed is lowered and new layers are added. The printer can currently lay down collagen at a resolution of around 20 micrometers, but will need to achieve resolution of a micrometer in size to make the lung functional.
Once a collagen lung scaffold has been printed, the next step is to infuse it with human cells, a process called recellularization.
The goal here is to use stem cells that grow on scaffolding and differentiate, ultimately providing the proper functionality. Early evidence indicates this approach can work.
In 2018, Harvard University experimental surgeon Harald Ott reported that he pumped billions of human cells (from umbilical cords and diced lungs) into a pig lung stripped of its own cells. When Ott’s team reconnected it to a pig’s circulation, the resulting organ showed rudimentary function.
Humanizing Pig Lungs
Another of Rothblatt’s organ manufacturing strategies is called xenotransplantation, the idea of transplanting an animal’s organs into humans who need a replacement.
Given the fact that adult pig organs are similar in size and shape to those of humans, United Therapeutics has focused on genetically engineering pigs to allow humans to use their organs. “It’s actually not rocket science,” said Rothblatt in her 2015 TED talk. “It’s editing one gene after another.”
To accomplish this goal, United Therapeutics made a series of investments in companies such as Revivicor Inc. and Synthetic Genomics Inc., and signed large funding agreements with the University of Maryland, University of Alabama, and New York Presbyterian/Columbia University Medical Center to create xenotransplantation programs for new hearts, kidneys, and lungs, respectively. Rothblatt hopes to see human translation in three to four years.
In preparation for that day, United Therapeutics owns a 132-acre property in Research Triangle Park and built a 275,000-square-foot medical laboratory that will ultimately have the capability to annually produce up to 1,000 sets of healthy pig lungs—known as xenolungs—from genetically engineered pigs.
Lung Ex Vivo Perfusion Systems
Beyond 3D printing and genetically engineering pig lungs, Rothblatt has already begun implementing a third near-term approach to improve the supply of lungs across the US.
Only about 30 percent of potential donor lungs meet transplant criteria in the first place; of those, only about 85 percent of those are usable once they arrive at the surgery center. As a result, nearly 75 percent of possible lungs never make it to the recipient in need.
What if these lungs could be rejuvenated? This concept informs Dr. Rothblatt’s next approach.
In 2016, United Therapeutics invested $41.8 million in TransMedics Inc., an Andover, Massachusetts company that develops ex vivo perfusion systems for donor lungs, hearts, and kidneys.
The XVIVO Perfusion System takes marginal-quality lungs that initially failed to meet transplantation standard-of-care criteria and perfuses and ventilates them at normothermic conditions, providing an opportunity for surgeons to reassess transplant suitability.
Rejuvenate Young Blood and Parabiosis
In HBO’s parody of the Bay Area tech community, Silicon Valley, one of the episodes (Season 4, Episode 5) is named “The Blood Boy.”
In this installment, tech billionaire Gavin Belson (Matt Ross) is meeting with Richard Hendricks (Thomas Middleditch) and his team, speaking about the future of the decentralized internet. A young, muscled twenty-something disrupts the meeting when he rolls in a transfusion stand and silently hooks an intravenous connection between himself and Belson.
Belson then introduces the newcomer as his “transfusion associate” and begins to explain the science of parabiosis: “Regular transfusions of the blood of a younger physically fit donor can significantly retard the aging process.”
While the sitcom is fiction, that science has merit, and the scenario portrayed in the episode is already happening today.
On the first point, research at Stanford and Harvard has demonstrated that older animals, when transfused with the blood of young animals, experience regeneration across many tissues and organs.
The opposite is also true: young animals, when transfused with the blood of older animals, experience accelerated aging. But capitalizing on this virtual fountain of youth has been tricky.
Ambrosia
One company, a San Francisco-based startup called Ambrosia, recently commenced one of the trials on parabiosis. Their protocol is simple: Healthy participants aged 35 and older get a transfusion of blood plasma from donors under 25, and researchers monitor their blood over the next two years for molecular indicators of health and aging.
Ambrosia’s founder Jesse Karmazin became interested in launching a company around parabiosis after seeing impressive data from animals and studies conducted abroad in humans: In one trial after another, subjects experience a reversal of aging symptoms across every major organ system. “The effects seem to be almost permanent,” he said. “It’s almost like there’s a resetting of gene expression.”
Infusing your own cord blood stem cells as you age may have tremendous longevity benefits. Following an FDA press release in February 2019, Ambrosia halted its consumer-facing treatment after several months of operation.
Understandably, the FDA raised concerns about the practice of parabiosis because to date, there is a marked lack of clinical data to support the treatment’s effectiveness.
Elevian
On the other end of the reputability spectrum is a startup called Elevian, spun out of Harvard University. Elevian is approaching longevity with a careful, scientifically validated strategy. (Full Disclosure: I am both an advisor to and investor in Elevian.)
CEO Mark Allen, MD, is joined by a dozen MDs and Ph.Ds out of Harvard. Elevian’s scientific founders started the company after identifying specific circulating factors that may be responsible for the “young blood” effect.
One example: A naturally occurring molecule known as “growth differentiation factor 11,” or GDF11, when injected into aged mice, reproduces many of the regenerative effects of young blood, regenerating heart, brain, muscles, lungs, and kidneys.
More specifically, GDF11 supplementation reduces age-related cardiac hypertrophy, accelerates skeletal muscle repair, improves exercise capacity, improves brain function and cerebral blood flow, and improves metabolism.
Elevian is developing a number of therapeutics that regulate GDF11 and other circulating factors. The goal is to restore our body’s natural regenerative capacity, which Elevian believes can address some of the root causes of age-associated disease with the promise of reversing or preventing many aging-related diseases and extending the healthy lifespan.
Conclusion
In 1992, futurist Leland Kaiser coined the term “regenerative medicine”:
“A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.”
Since then, the powerful regenerative medicine industry has grown exponentially, and this rapid growth is anticipated to continue.
A dramatic extension of the human healthspan is just over the horizon. Soon, we’ll all have the regenerative superpowers previously relegated to a handful of animals and comic books.
What new opportunities open up when anybody, anywhere, and at anytime can regenerate, replenish, and replace entire organs and metabolic systems on command?
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