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#437261 How AI Will Make Drug Discovery ...

If you had to guess how long it takes for a drug to go from an idea to your pharmacy, what would you guess? Three years? Five years? How about the cost? $30 million? $100 million?

Well, here’s the sobering truth: 90 percent of all drug possibilities fail. The few that do succeed take an average of 10 years to reach the market and cost anywhere from $2.5 billion to $12 billion to get there.

But what if we could generate novel molecules to target any disease, overnight, ready for clinical trials? Imagine leveraging machine learning to accomplish with 50 people what the pharmaceutical industry can barely do with an army of 5,000.

Welcome to the future of AI and low-cost, ultra-fast, and personalized drug discovery. Let’s dive in.

GANs & Drugs
Around 2012, computer scientist-turned-biophysicist Alex Zhavoronkov started to notice that artificial intelligence was getting increasingly good at image, voice, and text recognition. He knew that all three tasks shared a critical commonality. In each, massive datasets were available, making it easy to train up an AI.

But similar datasets were present in pharmacology. So, back in 2014, Zhavoronkov started wondering if he could use these datasets and AI to significantly speed up the drug discovery process. He’d heard about a new technique in artificial intelligence known as generative adversarial networks (or GANs). By pitting two neural nets against one another (adversarial), the system can start with minimal instructions and produce novel outcomes (generative). At the time, researchers had been using GANs to do things like design new objects or create one-of-a-kind, fake human faces, but Zhavoronkov wanted to apply them to pharmacology.

He figured GANs would allow researchers to verbally describe drug attributes: “The compound should inhibit protein X at concentration Y with minimal side effects in humans,” and then the AI could construct the molecule from scratch. To turn his idea into reality, Zhavoronkov set up Insilico Medicine on the campus of Johns Hopkins University in Baltimore, Maryland, and rolled up his sleeves.

Instead of beginning their process in some exotic locale, Insilico’s “drug discovery engine” sifts millions of data samples to determine the signature biological characteristics of specific diseases. The engine then identifies the most promising treatment targets and—using GANs—generates molecules (that is, baby drugs) perfectly suited for them. “The result is an explosion in potential drug targets and a much more efficient testing process,” says Zhavoronkov. “AI allows us to do with fifty people what a typical drug company does with five thousand.”

The results have turned what was once a decade-long war into a month-long skirmish.

In late 2018, for example, Insilico was generating novel molecules in fewer than 46 days, and this included not just the initial discovery, but also the synthesis of the drug and its experimental validation in computer simulations.

Right now, they’re using the system to hunt down new drugs for cancer, aging, fibrosis, Parkinson’s, Alzheimer’s, ALS, diabetes, and many others. The first drug to result from this work, a treatment for hair loss, is slated to start Phase I trials by the end of 2020.

They’re also in the early stages of using AI to predict the outcomes of clinical trials in advance of the trial. If successful, this technique will enable researchers to strip a bundle of time and money out of the traditional testing process.

Protein Folding
Beyond inventing new drugs, AI is also being used by other scientists to identify new drug targets—that is, the place to which a drug binds in the body and another key part of the drug discovery process.

Between 1980 and 2006, despite an annual investment of $30 billion, researchers only managed to find about five new drug targets a year. The trouble is complexity. Most potential drug targets are proteins, and a protein’s structure—meaning the way a 2D sequence of amino acids folds into a 3D protein—determines its function.

But a protein with merely a hundred amino acids (a rather small protein) can produce a googol-cubed worth of potential shapes—that’s a one followed by three hundred zeroes. This is also why protein-folding has long been considered an intractably hard problem for even the most powerful of supercomputers.

Back in 1994, to monitor supercomputers’ progress in protein-folding, a biannual competition was created. Until 2018, success was fairly rare. But then the creators of DeepMind turned their neural networks loose on the problem. They created an AI that mines enormous datasets to determine the most likely distance between a protein’s base pairs and the angles of their chemical bonds—aka, the basics of protein-folding. They called it AlphaFold.

On its first foray into the competition, contestant AIs were given 43 protein-folding problems to solve. AlphaFold got 25 right. The second-place team managed a meager three. By predicting the elusive ways in which various proteins fold on the basis of their amino acid sequences, AlphaFold may soon have a tremendous impact in aiding drug discovery and fighting some of today’s most intractable diseases.

Drug Delivery
Another theater of war for improved drugs is the realm of drug delivery. Even here, converging exponential technologies are paving the way for massive implications in both human health and industry shifts.

One key contender is CRISPR, the fast-advancing gene-editing technology that stands to revolutionize synthetic biology and treatment of genetically linked diseases. And researchers have now demonstrated how this tool can be applied to create materials that shape-shift on command. Think: materials that dissolve instantaneously when faced with a programmed stimulus, releasing a specified drug at a highly targeted location.

Yet another potential boon for targeted drug delivery is nanotechnology, whereby medical nanorobots have now been used to fight incidences of cancer. In a recent review of medical micro- and nanorobotics, lead authors (from the University of Texas at Austin and University of California, San Diego) found numerous successful tests of in vivo operation of medical micro- and nanorobots.

Drugs From the Future
Covid-19 is uniting the global scientific community with its urgency, prompting scientists to cast aside nation-specific territorialism, research secrecy, and academic publishing politics in favor of expedited therapeutic and vaccine development efforts. And in the wake of rapid acceleration across healthcare technologies, Big Pharma is an area worth watching right now, no matter your industry. Converging technologies will soon enable extraordinary strides in longevity and disease prevention, with companies like Insilico leading the charge.

Riding the convergence of massive datasets, skyrocketing computational power, quantum computing, cognitive surplus capabilities, and remarkable innovations in AI, we are not far from a world in which personalized drugs, delivered directly to specified targets, will graduate from science fiction to the standard of care.

Rejuvenational biotechnology will be commercially available sooner than you think. When I asked Alex for his own projection, he set the timeline at “maybe 20 years—that’s a reasonable horizon for tangible rejuvenational biotechnology.”

How might you use an extra 20 or more healthy years in your life? What impact would you be able to make?

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This article originally appeared on diamandis.com. Read the original article here.

Image Credit: andreas160578 from Pixabay Continue reading

Posted in Human Robots

#436234 Robot Gift Guide 2019

Welcome to the eighth edition of IEEE Spectrum’s Robot Gift Guide!

This year we’re featuring 15 robotic products that we think will make fantastic holiday gifts. As always, we tried to include a broad range of robot types and prices, focusing mostly on items released this year. (A reminder: While we provide links to places where you can buy these items, we’re not endorsing any in particular, and a little bit of research may result in better deals.)

If you need even more robot gift ideas, take a look at our past guides: 2018, 2017, 2016, 2015, 2014, 2013, and 2012. Some of those robots are still great choices and might be way cheaper now than when we first posted about them. And if you have suggestions that you’d like to share, post a comment below to help the rest of us find the perfect robot gift.

Skydio 2

Image: Skydio

What makes robots so compelling is their autonomy, and the Skydio 2 is one of the most autonomous robots we’ve ever seen. It uses an array of cameras to map its environment and avoid obstacles in real-time, making flight safe and effortless and enabling the kinds of shots that would be impossible otherwise. Seriously, this thing is magical, and it’s amazing that you can actually buy one.
$1,000
Skydio
UBTECH Jimu MeeBot 2

Image: UBTECH

The Jimu MeeBot 2.0 from UBTECH is a STEM education robot designed to be easy to build and program. It includes six servo motors, a color sensor, and LED lights. An app for iPhone or iPad provides step-by-step 3D instructions, and helps you code different behaviors for the robot. It’s available exclusively from Apple.
$130
Apple
iRobot Roomba s9+

Image: iRobot

We know that $1,400 is a crazy amount of money to spend on a robot vacuum, but the Roomba s9+ is a crazy robot vacuum. As if all of its sensors and mapping intelligence wasn’t enough, it empties itself, which means that you can have your floors vacuumed every single day for a month and you don’t have to even think about it. This is what home robots are supposed to be.
$1,400
iRobot
PFF Gita

Photo: Piaggio Fast Forward

Nobody likes carrying things, which is why Gita is perfect for everyone with an extra $3,000 lying around. Developed by Piaggio Fast Forward, this autonomous robot will follow you around with a cargo hold full of your most important stuff, and do it in a way guaranteed to attract as much attention as possible.
$3,250
Gita
DJI Mavic Mini

Photo: DJI

It’s tiny, it’s cheap, and it takes good pictures—what more could you ask for from a drone? And for $400, this is an excellent drone to get if you’re on a budget and comfortable with manual flight. Keep in mind that while the Mavic Mini is small enough that you don’t need to register it with the FAA, you do still need to follow all the same rules and regulations.
$400
DJI
LEGO Star Wars Droid Commander

Image: LEGO

Designed for kids ages 8+, this LEGO set includes more than 1,000 pieces, enough to build three different droids: R2-D2, Gonk Droid, and Mouse Droid. Using a Bluetooth-controlled robotic brick called Move Hub, which connects to the LEGO BOOST Star Wars app, kids can change how the robots behave and solve challenges, learning basic robotics and coding skills.
$200
LEGO
Sony Aibo

Photo: Sony

Robot pets don’t get much more sophisticated (or expensive) than Sony’s Aibo. Strictly speaking, it’s one of the most complex consumer robots you can buy, and Sony continues to add to Aibo’s software. Recent new features include user programmability, and the ability to “feed” it.
$2,900 (free aibone and paw pads until 12/29/2019)
Sony
Neato Botvac D4 Connected

Photo: Neato

The Neato Botvac D4 may not have all of the features of its fancier and more expensive siblings, but it does have the features that you probably care the most about: The ability to make maps of its environment for intelligent cleaning (using lasers!), along with user-defined no-go lines that keep it where you want it. And it cleans quite well, too.
$530 $350 (sale)
Neato Robotics
Cubelets Curiosity Set

Photo: Modular Robotics

Cubelets are magnetic blocks that you can snap together to make an endless variety of robots with no programming and no wires. The newest set, called Curiosity, is designed for kids ages 4+ and comes with 10 robotic cubes. These include light and distance sensors, motors, and a Bluetooth module, which connects the robot constructions to the Cubelets app.
$250
Modular Robotics
Tertill

Photo: Franklin Robotics

Tertill does one simple job: It weeds your garden. It’s waterproof, dirt proof, solar powered, and fully autonomous, meaning that you can leave it out in your garden all summer and just enjoy eating your plants rather than taking care of them.
$350
Tertill
iRobot Root

Photo: iRobot

Root was originally developed by Harvard University as a tool to help kids progressively learn to code. iRobot has taken over Root and is now supporting the curriculum, which starts for kids before they even know how to read and should keep them busy for years afterwards.
$200
iRobot
LOVOT

Image: Lovot

Let’s be honest: Nobody is really quite sure what LOVOT is. We can all agree that it’s kinda cute, though. And kinda weird. But cute. Created by Japanese robotics startup Groove X, LOVOT does have a whole bunch of tech packed into its bizarre little body and it will do its best to get you to love it.
$2,750 (¥300,000)
LOVOT
Sphero RVR

Photo: Sphero

RVR is a rugged, versatile, easy to program mobile robot. It’s a development platform designed to be a bridge between educational robots like Sphero and more sophisticated and expensive systems like Misty. It’s mostly affordable, very expandable, and comes from a company with a lot of experience making robots.
$250
Sphero
“How to Train Your Robot”

Image: Lawrence Hall of Science

Aimed at 4th and 5th graders, “How to Train Your Robot,” written by Blooma Goldberg, Ken Goldberg, and Ashley Chase, and illustrated by Dave Clegg, is a perfect introduction to robotics for kids who want to get started with designing and building robots. But the book isn’t just for beginners: It’s also a fun, inspiring read for kids who are already into robotics and want to go further—it even introduces concepts like computer simulations and deep learning. You can download a free digital copy or request hardcopies here.
Free
UC Berkeley
MIT Mini Cheetah

Photo: MIT

Yes, Boston Dynamics’ Spot, now available for lease, is probably the world’s most famous quadruped, but MIT is starting to pump out Mini Cheetahs en masse for researchers, and while we’re not exactly sure how you’d manage to get one of these things short of stealing one directly for MIT, a Mini Cheetah is our fantasy robotics gift this year. Mini Cheetah looks like a ton of fun—it’s portable, highly dynamic, super rugged, and easy to control. We want one!
Price N/A
MIT Biomimetic Robotics Lab

For more tech gift ideas, see also IEEE Spectrum’s annual Gift Guide. Continue reading

Posted in Human Robots

#436188 The Blogger Behind “AI ...

Sure, artificial intelligence is transforming the world’s societies and economies—but can an AI come up with plausible ideas for a Halloween costume?

Janelle Shane has been asking such probing questions since she started her AI Weirdness blog in 2016. She specializes in training neural networks (which underpin most of today’s machine learning techniques) on quirky data sets such as compilations of knitting instructions, ice cream flavors, and names of paint colors. Then she asks the neural net to generate its own contributions to these categories—and hilarity ensues. AI is not likely to disrupt the paint industry with names like “Ronching Blue,” “Dorkwood,” and “Turdly.”

Shane’s antics have a serious purpose. She aims to illustrate the serious limitations of today’s AI, and to counteract the prevailing narrative that describes AI as well on its way to superintelligence and complete human domination. “The danger of AI is not that it’s too smart,” Shane writes in her new book, “but that it’s not smart enough.”

The book, which came out on Tuesday, is called You Look Like a Thing and I Love You. It takes its odd title from a list of AI-generated pick-up lines, all of which would at least get a person’s attention if shouted, preferably by a robot, in a crowded bar. Shane’s book is shot through with her trademark absurdist humor, but it also contains real explanations of machine learning concepts and techniques. It’s a painless way to take AI 101.

She spoke with IEEE Spectrum about the perils of placing too much trust in AI systems, the strange AI phenomenon of “giraffing,” and her next potential Halloween costume.

Janelle Shane on . . .

The un-delicious origin of her blog
“The narrower the problem, the smarter the AI will seem”
Why overestimating AI is dangerous
Giraffing!
Machine and human creativity

The un-delicious origin of her blog IEEE Spectrum: You studied electrical engineering as an undergrad, then got a master’s degree in physics. How did that lead to you becoming the comedian of AI?
Janelle Shane: I’ve been interested in machine learning since freshman year of college. During orientation at Michigan State, a professor who worked on evolutionary algorithms gave a talk about his work. It was full of the most interesting anecdotes–some of which I’ve used in my book. He told an anecdote about people setting up a machine learning algorithm to do lens design, and the algorithm did end up designing an optical system that works… except one of the lenses was 50 feet thick, because they didn’t specify that it couldn’t do that.
I started working in his lab on optics, doing ultra-short laser pulse work. I ended up doing a lot more optics than machine learning, but I always found it interesting. One day I came across a list of recipes that someone had generated using a neural net, and I thought it was hilarious and remembered why I thought machine learning was so cool. That was in 2016, ages ago in machine learning land.
Spectrum: So you decided to “establish weirdness as your goal” for your blog. What was the first weird experiment that you blogged about?
Shane: It was generating cookbook recipes. The neural net came up with ingredients like: “Take ¼ pounds of bones or fresh bread.” That recipe started out: “Brown the salmon in oil, add creamed meat to the mixture.” It was making mistakes that showed the thing had no memory at all.
Spectrum: You say in the book that you can learn a lot about AI by giving it a task and watching it flail. What do you learn?
Shane: One thing you learn is how much it relies on surface appearances rather than deep understanding. With the recipes, for example: It got the structure of title, category, ingredients, instructions, yield at the end. But when you look more closely, it has instructions like “Fold the water and roll it into cubes.” So clearly this thing does not understand water, let alone the other things. It’s recognizing certain phrases that tend to occur, but it doesn’t have a concept that these recipes are describing something real. You start to realize how very narrow the algorithms in this world are. They only know exactly what we tell them in our data set.
BACK TO TOP↑ “The narrower the problem, the smarter the AI will seem” Spectrum: That makes me think of DeepMind’s AlphaGo, which was universally hailed as a triumph for AI. It can play the game of Go better than any human, but it doesn’t know what Go is. It doesn’t know that it’s playing a game.
Shane: It doesn’t know what a human is, or if it’s playing against a human or another program. That’s also a nice illustration of how well these algorithms do when they have a really narrow and well-defined problem.
The narrower the problem, the smarter the AI will seem. If it’s not just doing something repeatedly but instead has to understand something, coherence goes down. For example, take an algorithm that can generate images of objects. If the algorithm is restricted to birds, it could do a recognizable bird. If this same algorithm is asked to generate images of any animal, if its task is that broad, the bird it generates becomes an unrecognizable brown feathered smear against a green background.
Spectrum: That sounds… disturbing.
Shane: It’s disturbing in a weird amusing way. What’s really disturbing is the humans it generates. It hasn’t seen them enough times to have a good representation, so you end up with an amorphous, usually pale-faced thing with way too many orifices. If you asked it to generate an image of a person eating pizza, you’ll have blocks of pizza texture floating around. But if you give that image to an image-recognition algorithm that was trained on that same data set, it will say, “Oh yes, that’s a person eating pizza.”
BACK TO TOP↑ Why overestimating AI is dangerous Spectrum: Do you see it as your role to puncture the AI hype?
Shane: I do see it that way. Not a lot of people are bringing out this side of AI. When I first started posting my results, I’d get people saying, “I don’t understand, this is AI, shouldn’t it be better than this? Why doesn't it understand?” Many of the impressive examples of AI have a really narrow task, or they’ve been set up to hide how little understanding it has. There’s a motivation, especially among people selling products based on AI, to represent the AI as more competent and understanding than it actually is.
Spectrum: If people overestimate the abilities of AI, what risk does that pose?
Shane: I worry when I see people trusting AI with decisions it can’t handle, like hiring decisions or decisions about moderating content. These are really tough tasks for AI to do well on. There are going to be a lot of glitches. I see people saying, “The computer decided this so it must be unbiased, it must be objective.”

“If the algorithm’s task is to replicate human hiring decisions, it’s going to glom onto gender bias and race bias.”
—Janelle Shane, AI Weirdness blogger
That’s another thing I find myself highlighting in the work I’m doing. If the data includes bias, the algorithm will copy that bias. You can’t tell it not to be biased, because it doesn’t understand what bias is. I think that message is an important one for people to understand.
If there’s bias to be found, the algorithm is going to go after it. It’s like, “Thank goodness, finally a signal that’s reliable.” But for a tough problem like: Look at these resumes and decide who’s best for the job. If its task is to replicate human hiring decisions, it’s going to glom onto gender bias and race bias. There’s an example in the book of a hiring algorithm that Amazon was developing that discriminated against women, because the historical data it was trained on had that gender bias.
Spectrum: What are the other downsides of using AI systems that don’t really understand their tasks?
Shane: There is a risk in putting too much trust in AI and not examining its decisions. Another issue is that it can solve the wrong problems, without anyone realizing it. There have been a couple of cases in medicine. For example, there was an algorithm that was trained to recognize things like skin cancer. But instead of recognizing the actual skin condition, it latched onto signals like the markings a surgeon makes on the skin, or a ruler placed there for scale. It was treating those things as a sign of skin cancer. It’s another indication that these algorithms don’t understand what they’re looking at and what the goal really is.
BACK TO TOP↑ Giraffing Spectrum: In your blog, you often have neural nets generate names for things—such as ice cream flavors, paint colors, cats, mushrooms, and types of apples. How do you decide on topics?
Shane: Quite often it’s because someone has written in with an idea or a data set. They’ll say something like, “I’m the MIT librarian and I have a whole list of MIT thesis titles.” That one was delightful. Or they’ll say, “We are a high school robotics team, and we know where there’s a list of robotics team names.” It’s fun to peek into a different world. I have to be careful that I’m not making fun of the naming conventions in the field. But there’s a lot of humor simply in the neural net’s complete failure to understand. Puns in particular—it really struggles with puns.
Spectrum: Your blog is quite absurd, but it strikes me that machine learning is often absurd in itself. Can you explain the concept of giraffing?
Shane: This concept was originally introduced by [internet security expert] Melissa Elliott. She proposed this phrase as a way to describe the algorithms’ tendency to see giraffes way more often than would be likely in the real world. She posted a whole bunch of examples, like a photo of an empty field in which an image-recognition algorithm has confidently reported that there are giraffes. Why does it think giraffes are present so often when they’re actually really rare? Because they’re trained on data sets from online. People tend to say, “Hey look, a giraffe!” And then take a photo and share it. They don’t do that so often when they see an empty field with rocks.
There’s also a chatbot that has a delightful quirk. If you show it some photo and ask it how many giraffes are in the picture, it will always answer with some non zero number. This quirk comes from the way the training data was generated: These were questions asked and answered by humans online. People tended not to ask the question “How many giraffes are there?” when the answer was zero. So you can show it a picture of someone holding a Wii remote. If you ask it how many giraffes are in the picture, it will say two.
BACK TO TOP↑ Machine and human creativity Spectrum: AI can be absurd, and maybe also creative. But you make the point that AI art projects are really human-AI collaborations: Collecting the data set, training the algorithm, and curating the output are all artistic acts on the part of the human. Do you see your work as a human-AI art project?
Shane: Yes, I think there is artistic intent in my work; you could call it literary or visual. It’s not so interesting to just take a pre-trained algorithm that’s been trained on utilitarian data, and tell it to generate a bunch of stuff. Even if the algorithm isn’t one that I’ve trained myself, I think about, what is it doing that’s interesting, what kind of story can I tell around it, and what do I want to show people.

The Halloween costume algorithm “was able to draw on its knowledge of which words are related to suggest things like sexy barnacle.”
—Janelle Shane, AI Weirdness blogger
Spectrum: For the past three years you’ve been getting neural nets to generate ideas for Halloween costumes. As language models have gotten dramatically better over the past three years, are the costume suggestions getting less absurd?
Shane: Yes. Before I would get a lot more nonsense words. This time I got phrases that were related to real things in the data set. I don’t believe the training data had the words Flying Dutchman or barnacle. But it was able to draw on its knowledge of which words are related to suggest things like sexy barnacle and sexy Flying Dutchman.
Spectrum: This year, I saw on Twitter that someone made the gothy giraffe costume happen. Would you ever dress up for Halloween in a costume that the neural net suggested?
Shane: I think that would be fun. But there would be some challenges. I would love to go as the sexy Flying Dutchman. But my ambition may constrict me to do something more like a list of leg parts.
BACK TO TOP↑ Continue reading

Posted in Human Robots

#436140 Let’s Build Robots That Are as Smart ...

Illustration: Nicholas Little

Let’s face it: Robots are dumb. At best they are idiot savants, capable of doing one thing really well. In general, even those robots require specialized environments in which to do their one thing really well. This is why autonomous cars or robots for home health care are so difficult to build. They’ll need to react to an uncountable number of situations, and they’ll need a generalized understanding of the world in order to navigate them all.

Babies as young as two months already understand that an unsupported object will fall, while five-month-old babies know materials like sand and water will pour from a container rather than plop out as a single chunk. Robots lack these understandings, which hinders them as they try to navigate the world without a prescribed task and movement.

But we could see robots with a generalized understanding of the world (and the processing power required to wield it) thanks to the video-game industry. Researchers are bringing physics engines—the software that provides real-time physical interactions in complex video-game worlds—to robotics. The goal is to develop robots’ understanding in order to learn about the world in the same way babies do.

Giving robots a baby’s sense of physics helps them navigate the real world and can even save on computing power, according to Lochlainn Wilson, the CEO of SE4, a Japanese company building robots that could operate on Mars. SE4 plans to avoid the problems of latency caused by distance from Earth to Mars by building robots that can operate independently for a few hours before receiving more instructions from Earth.

Wilson says that his company uses simple physics engines such as PhysX to help build more-independent robots. He adds that if you can tie a physics engine to a coprocessor on the robot, the real-time basic physics intuitions won’t take compute cycles away from the robot’s primary processor, which will often be focused on a more complicated task.

Wilson’s firm occasionally still turns to a traditional graphics engine, such as Unity or the Unreal Engine, to handle the demands of a robot’s movement. In certain cases, however, such as a robot accounting for friction or understanding force, you really need a robust physics engine, Wilson says, not a graphics engine that simply simulates a virtual environment. For his projects, he often turns to the open-source Bullet Physics engine built by Erwin Coumans, who is now an employee at Google.

Bullet is a popular physics-engine option, but it isn’t the only one out there. Nvidia Corp., for example, has realized that its gaming and physics engines are well-placed to handle the computing demands required by robots. In a lab in Seattle, Nvidia is working with teams from the University of Washington to build kitchen robots, fully articulated robot hands and more, all equipped with Nvidia’s tech.

When I visited the lab, I watched a robot arm move boxes of food from counters to cabinets. That’s fairly straightforward, but that same robot arm could avoid my body if I got in its way, and it could adapt if I moved a box of food or dropped it onto the floor.

The robot could also understand that less pressure is needed to grasp something like a cardboard box of Cheez-It crackers versus something more durable like an aluminum can of tomato soup.

Nvidia’s silicon has already helped advance the fields of artificial intelligence and computer vision by making it possible to process multiple decisions in parallel. It’s possible that the company’s new focus on virtual worlds will help advance the field of robotics and teach robots to think like babies.

This article appears in the November 2019 print issue as “Robots as Smart as Babies.” Continue reading

Posted in Human Robots

#435589 Construction Robots Learn to Excavate by ...

Pavel Savkin remembers the first time he watched a robot imitate his movements. Minutes earlier, the engineer had finished “showing” the robotic excavator its new goal by directing its movements manually. Now, running on software Savkin helped design, the robot was reproducing his movements, gesture for gesture. “It was like there was something alive in there—but I knew it was me,” he said.

Savkin is the CTO of SE4, a robotics software project that styles itself the “driver” of a fleet of robots that will eventually build human colonies in space. For now, SE4 is focused on creating software that can help developers communicate with robots, rather than on building hardware of its own.
The Tokyo-based startup showed off an industrial arm from Universal Robots that was running SE4’s proprietary software at SIGGRAPH in July. SE4’s demonstration at the Los Angeles innovation conference drew the company’s largest audience yet. The robot, nicknamed Squeezie, stacked real blocks as directed by SE4 research engineer Nathan Quinn, who wore a VR headset and used handheld controls to “show” Squeezie what to do.

As Quinn manipulated blocks in a virtual 3D space, the software learned a set of ordered instructions to be carried out in the real world. That order is essential for remote operations, says Quinn. To build remotely, developers need a way to communicate instructions to robotic builders on location. In the age of digital construction and industrial robotics, giving a computer a blueprint for what to build is a well-explored art. But operating on a distant object—especially under conditions that humans haven’t experienced themselves—presents challenges that only real-time communication with operators can solve.

The problem is that, in an unpredictable setting, even simple tasks require not only instruction from an operator, but constant feedback from the changing environment. Five years ago, the Swedish fiber network provider umea.net (part of the private Umeå Energy utility) took advantage of the virtual reality boom to promote its high-speed connections with the help of a viral video titled “Living with Lag: An Oculus Rift Experiment.” The video is still circulated in VR and gaming circles.

In the experiment, volunteers donned headgear that replaced their real-time biological senses of sight and sound with camera and audio feeds of their surroundings—both set at a 3-second delay. Thus equipped, volunteers attempt to complete everyday tasks like playing ping-pong, dancing, cooking, and walking on a beach, with decidedly slapstick results.

At outer-orbit intervals, including SE4’s dream of construction projects on Mars, the limiting factor in communication speed is not an artificial delay, but the laws of physics. The shifting relative positions of Earth and Mars mean that communications between the planets—even at the speed of light—can take anywhere from 3 to 22 minutes.

A long-distance relationship

Imagine trying to manage a construction project from across an ocean without the benefit of intelligent workers: sending a ship to an unknown world with a construction crew and blueprints for a log cabin, and four months later receiving a letter back asking how to cut down a tree. The parallel problem in long-distance construction with robots, according to SE4 CEO Lochlainn Wilson, is that automation relies on predictability. “Every robot in an industrial setting today is expecting a controlled environment.”
Platforms for applying AR and VR systems to teach tasks to artificial intelligences, as SE4 does, are already proliferating in manufacturing, healthcare, and defense. But all of the related communications systems are bound by physics and, specifically, the speed of light.
The same fundamental limitation applies in space. “Our communications are light-based, whether they’re radio or optical,” says Laura Seward Forczyk, a planetary scientist and consultant for space startups. “If you’re going to Mars and you want to communicate with your robot or spacecraft there, you need to have it act semi- or mostly-independently so that it can operate without commands from Earth.”

Semantic control
That’s exactly what SE4 aims to do. By teaching robots to group micro-movements into logical units—like all the steps to building a tower of blocks—the Tokyo-based startup lets robots make simple relational judgments that would allow them to receive a full set of instruction modules at once and carry them out in order. This sidesteps the latency issue in real-time bilateral communications that could hamstring a project or at least make progress excruciatingly slow.
The key to the platform, says Wilson, is the team’s proprietary operating software, “Semantic Control.” Just as in linguistics and philosophy, “semantics” refers to meaning itself, and meaning is the key to a robot’s ability to make even the smallest decisions on its own. “A robot can scan its environment and give [raw data] to us, but it can’t necessarily identify the objects around it and what they mean,” says Wilson.

That’s where human intelligence comes in. As part of the demonstration phase, the human operator of an SE4-controlled machine “annotates” each object in the robot’s vicinity with meaning. By labeling objects in the VR space with useful information—like which objects are building material and which are rocks—the operator helps the robot make sense of its real 3D environment before the building begins.

Giving robots the tools to deal with a changing environment is an important step toward allowing the AI to be truly independent, but it’s only an initial step. “We’re not letting it do absolutely everything,” said Quinn. “Our robot is good at moving an object from point A to point B, but it doesn’t know the overall plan.” Wilson adds that delegating environmental awareness and raw mechanical power to separate agents is the optimal relationship for a mixed human-robot construction team; it “lets humans do what they’re good at, while robots do what they do best.”

This story was updated on 4 September 2019. Continue reading

Posted in Human Robots