Tag Archives: implants
#436962 Scientists Engineered Neurons to Make ...
Electricity plays a surprisingly powerful role in our bodies. While most people are aware that it plays a crucial role in carrying signals to and from our nerves, our bodies produce electric fields that can do everything from helping heal wounds to triggering the release of hormones.
Electric fields can influence a host of important cellular behavior, like directional migration, proliferation, division, or even differentiation into different cell types. The work of Michael Levin at Tufts University even suggests that electrical fields may play a crucial role in the way our bodies organize themselves.
This has prompted considerable interest in exploiting our body’s receptiveness to electrical stimulation for therapeutic means, but given the diffuse nature of electrical fields a key challenge is finding a way to localize these effects. Conductive polymers have proven a useful tool in this regard thanks to their good electrical properties and biocompatibility, and have been used in everything from neural implants to biosensors.
But now, a team at Stanford University has developed a way to genetically engineer neurons to build the materials into their own cell membranes. The approach could make it possible to target highly specific groups of cells, providing unprecedented control over the body’s response to electrical stimulation.
In a paper in Science, the team explained how they used re-engineered viruses to deliver DNA that hijacks cells’ biosynthesis machinery to create an enzyme that assembles electroactive polymers onto their membranes. This changes the electrical properties of the cells, which the team demonstrated could be used to control their behavior.
They used the approach to modulate neuronal firing in cultures of rat hippocampal neurons, mouse brain slices, and even human cortical spheroids. Most impressively, they showed that they could coax the neurons of living C. elegans worms to produce the polymers in large enough quantities to alter their behavior without impairing the cells’ natural function.
Translating the idea to humans poses major challenges, not least because the viruses used to deliver the genetic changes are still a long way from being approved for clinical use. But the ability to precisely target specific cells using a genetic approach holds enormous promise for bioelectronic medicine, Kevin Otto and Christine Schmidt from the University of Florida say in an accompanying perspective.
Interest is booming in therapies that use electrical stimulation of neural circuits as an alternative to drugs for diseases as varied as arthritis, Alzheimer’s, diabetes, and cardiovascular disease, and hundreds of clinical trials are currently underway.
At present these approaches rely on electrodes that can provide some level of localization, but because different kinds of nerve cells are often packed closely together it’s proven hard to stimulate exactly the right nerves, say Otto and Schmidt. This new approach makes it possible to boost the conductivity of specific cell types, which could make these kinds of interventions dramatically more targeted.
Besides disease-focused bioelectronic interventions, Otto and Schmidt say the approach could prove invaluable for helping to interface advanced prosthetics with patients’ nervous systems by making it possible to excite sensory neurons without accidentally triggering motor neurons, or vice versa.
More speculatively, the approach could one day help create far more efficient bridges between our minds and machines. One of the major challenges for brain-machine interfaces is recording from specific neurons, something that a genetically targeted approach might be able to help greatly with.
If the researchers can replicate the ability to build electronic-tissue “composites” in humans, we may be well on our way to the cyborg future predicted by science fiction.
Image Credit: Gerd Altmann from Pixabay Continue reading
#435462 Where Death Ends and Cyborgs Begin, With ...
Transhumanism is a growing movement but also one of the most controversial. Though there are many varying offshoots within the movement, the general core idea is the same: evolve and enhance human beings by integrating biology with technology.
We recently sat down with one of the most influential and vocal transhumanists, author and futurist Zoltan Istvan, on the latest episode of Singularity University Radio’s podcast series: The Feedback Loop, to discuss his ideas on technological implants, religion, transhumanism, and death.
Although Zoltan’s origin story is rooted deeply in his time as a reporter for National Geographic, much of his rise to prominence has been a result of his contributions to a variety of media outlets, including an appearance on the Joe Rogan podcast. Additionally, many of you may know him from his novel, The Transhumanist Wager, and his 2016 presidential campaign, where he drove around the United States in a bus that had been remodeled into the shape of a coffin.
Although Zoltan had no illusions about actually winning the presidency, he had hoped that the “immortality bus” and his campaign might help inject more science, technology, and longevity research into the political discourse, or at the very least spark a more serious conversation around the future of our species.
Only time will tell if his efforts paid off, but in the meantime, you can hear Zoltan discuss religion, transhumanism, implants, the existential motivation of death, and the need for new governmental policies in Episode 7 of The Feedback Loop. To listen in each week you can find us on your favorite podcasting platforms, such as Spotify, Apple, or Google, and you can find links to other podcasting platforms and Singularity Hub’s text-to-speech articles here. You can also find our past episodes with other thought leaders like Douglas Rushkoff and Annaka Harris below.
Image Credit: VAlex / Shutterstock.com Continue reading