Tag Archives: humanity
#436578 AI Just Discovered a New Antibiotic to ...
Penicillin, one of the greatest discoveries in the history of medicine, was a product of chance.
After returning from summer vacation in September 1928, bacteriologist Alexander Fleming found a colony of bacteria he’d left in his London lab had sprouted a fungus. Curiously, wherever the bacteria contacted the fungus, their cell walls broke down and they died. Fleming guessed the fungus was secreting something lethal to the bacteria—and the rest is history.
Fleming’s discovery of penicillin and its later isolation, synthesis, and scaling in the 1940s released a flood of antibiotic discoveries in the next few decades. Bacteria and fungi had been waging an ancient war against each other, and the weapons they’d evolved over eons turned out to be humanity’s best defense against bacterial infection and disease.
In recent decades, however, the flood of new antibiotics has slowed to a trickle.
Their development is uneconomical for drug companies, and the low-hanging fruit has long been picked. We’re now facing the emergence of strains of super bacteria resistant to one or more antibiotics and an aging arsenal to fight them with. Gone unchallenged, an estimated 700,000 deaths worldwide due to drug resistance could rise to as many as 10 million in 2050.
Increasingly, scientists warn the tide is turning, and we need a new strategy to keep pace with the remarkably quick and boundlessly creative tactics of bacterial evolution.
But where the golden age of antibiotics was sparked by serendipity, human intelligence, and natural molecular weapons, its sequel may lean on the uncanny eye of artificial intelligence to screen millions of compounds—and even design new ones—in search of the next penicillin.
Hal Discovers a Powerful Antibiotic
In a paper published this week in the journal, Cell, MIT researchers took a step in this direction. The team says their machine learning algorithm discovered a powerful new antibiotic.
Named for the AI in 2001: A Space Odyssey, the antibiotic, halicin, successfully wiped out dozens of bacterial strains, including some of the most dangerous drug-resistant bacteria on the World Health Organization’s most wanted list. The bacteria also failed to develop resistance to E. coli during a month of observation, in stark contrast to existing antibiotic ciprofloxacin.
“In terms of antibiotic discovery, this is absolutely a first,” Regina Barzilay, a senior author on the study and computer science professor at MIT, told The Guardian.
The algorithm that discovered halicin was trained on the molecular features of 2,500 compounds. Nearly half were FDA-approved drugs, and another 800 naturally occurring. The researchers specifically tuned the algorithm to look for molecules with antibiotic properties but whose structures would differ from existing antibiotics (as halicin’s does). Using another machine learning program, they screened the results for those likely to be safe for humans.
Early study suggests halicin attacks the bacteria’s cell membranes, disrupting their ability to produce energy. Protecting the cell membrane from halicin might take more than one or two genetic mutations, which could account for its impressive ability to prevent resistance.
“I think this is one of the more powerful antibiotics that has been discovered to date,” James Collins, an MIT professor of bioengineering and senior author told The Guardian. “It has remarkable activity against a broad range of antibiotic-resistant pathogens.”
Beyond tests in petri-dish bacterial colonies, the team also tested halicin in mice. The antibiotic cleared up infections of a strain of bacteria resistant to all known antibiotics in a day. The team plans further study in partnership with a pharmaceutical company or nonprofit, and they hope to eventually prove it safe and effective for use in humans.
This last bit remains the trickiest step, given the cost of getting a new drug approved. But Collins hopes algorithms like theirs will help. “We could dramatically reduce the cost required to get through clinical trials,” he told the Financial Times.
A Universe of Drugs Awaits
The bigger story may be what happens next.
How many novel antibiotics await discovery, and how far can AI screening take us? The initial 6,000 compounds scanned by Barzilay and Collins’s team is a drop in the bucket.
They’ve already begun digging deeper by setting the algorithm loose on 100 million molecules from an online library of 1.5 billion compounds called the ZINC15 database. This first search took three days and turned up 23 more candidates that, like halicin, differ structurally from existing antibiotics and may be safe for humans. Two of these—which the team will study further—appear to be especially powerful.
Even more ambitiously, Barzilay hopes the approach can find or even design novel antibiotics that kill bad bacteria with alacrity while sparing the good guys. In this way, a round of antibiotics would cure whatever ails you without taking out your whole gut microbiome in the process.
All this is part of a larger movement to use machine learning algorithms in the long, expensive process of drug discovery. Other players in the area are also training AI on the vast possibility space of drug-like compounds. Last fall, one of the leaders in the area, Insilico, was challenged by a partner to see just how fast their method could do the job. The company turned out a new a proof-of-concept drug candidate in only 46 days.
The field is still developing, however, and it has yet to be seen exactly how valuable these approaches will be in practice. Barzilay is optimistic though.
“There is still a question of whether machine-learning tools are really doing something intelligent in healthcare, and how we can develop them to be workhorses in the pharmaceuticals industry,” she said. “This shows how far you can adapt this tool.”
Image Credit: Halicin (top row) prevented the development of antibiotic resistance in E. coli, while ciprofloxacin (bottom row) did not. Collins Lab at MIT Continue reading
Posted in Human Robots
#436218 An AI Debated Its Own Potential for Good ...
Artificial intelligence is going to overhaul the way we live and work. But will the changes it brings be for the better? As the technology slowly develops (let’s remember that right now, we’re still very much in the narrow AI space and nowhere near an artificial general intelligence), whether it will end up doing us more harm than good is a question at the top of everyone’s mind.
What kind of response might we get if we posed this question to an AI itself?
Last week at the Cambridge Union in England, IBM did just that. Its Project Debater (an AI that narrowly lost a debate to human debating champion Harish Natarajan in February) gave the opening arguments in a debate about the promise and peril of artificial intelligence.
Critical thinking, linking different lines of thought, and anticipating counter-arguments are all valuable debating skills that humans can practice and refine. While these skills are tougher for an AI to get good at since they often require deeper contextual understanding, AI does have a major edge over humans in absorbing and analyzing information. In the February debate, Project Debater used IBM’s cloud computing infrastructure to read hundreds of millions of documents and extract relevant details to construct an argument.
This time around, Debater looked through 1,100 arguments for or against AI. The arguments were submitted to IBM by the public during the week prior to the debate, through a website set up for that purpose. Of the 1,100 submissions, the AI classified 570 as anti-AI, or of the opinion that the technology will bring more harm to humanity than good. 511 arguments were found to be pro-AI, and the rest were irrelevant to the topic at hand.
Debater grouped the arguments into five themes; the technology’s ability to take over dangerous or monotonous jobs was a pro-AI theme, and on the flip side was its potential to perpetuate the biases of its creators. “AI companies still have too little expertise on how to properly assess datasets and filter out bias,” the tall black box that houses Project Debater said. “AI will take human bias and will fixate it for generations.”
After Project Debater kicked off the debate by giving opening arguments for both sides, two teams of people took over, elaborating on its points and coming up with their own counter-arguments.
In the end, an audience poll voted in favor of the pro-AI side, but just barely; 51.2 percent of voters felt convinced that AI can help us more than it can hurt us.
The software’s natural language processing was able to identify racist, obscene, or otherwise inappropriate comments and weed them out as being irrelevant to the debate. But it also repeated the same arguments multiple times, and mixed up a statement about bias as being pro-AI rather than anti-AI.
IBM has been working on Project Debater for over six years, and though it aims to iron out small glitches like these, the system’s goal isn’t to ultimately outwit and defeat humans. On the contrary, the AI is meant to support our decision-making by taking in and processing huge amounts of information in a nuanced way, more quickly than we ever could.
IBM engineer Noam Slonim envisions Project Debater’s tech being used, for example, by a government seeking citizens’ feedback about a new policy. “This technology can help to establish an interesting and effective communication channel between the decision maker and the people that are going to be impacted by the decision,” he said.
As for the question of whether AI will do more good or harm, perhaps Sylvie Delacroix put it best. A professor of law and ethics at the University of Birmingham who argued on the pro-AI side of the debate, she pointed out that the impact AI will have depends on the way we design it, saying “AI is only as good as the data it has been fed.”
She’s right; rather than asking what sort of impact AI will have on humanity, we should start by asking what sort of impact we want it to have. The people working on AI—not AIs themselves—are ultimately responsible for how much good or harm will be done.
Image Credit: IBM Project Debater at Cambridge Union Society, photo courtesy of IBM Research Continue reading
Posted in Human Robots