Tag Archives: history

#434544 This Week’s Awesome Stories From ...

Posted on January 26, 2019 by Android

ARTIFICIAL INTELLIGENCE
DeepMind Beats Pros at Starcraft in Another Triumph for Bots
Tom Simonite | Wired
“DeepMind’s feat is the most complex yet in a long train of contests in which computers have beaten top humans at games. Checkers fell in 1994, chess in 1997, and DeepMind’s earlier bot AlphaGo became the first to beat a champion at the board game Go in 2016. The StarCraft bot is the most powerful AI game player yet; it may also be the least unexpected.”

GENETICS
Complete Axolotl Genome Could Pave the Way Toward Human Tissue Regeneration
George Dvorsky | Gizmodo
“Now that researchers have a near-complete axolotl genome—the new assembly still requires a bit of fine-tuning (more on that in a bit)—they, along with others, can now go about the work of identifying the genes responsible for axolotl tissue regeneration.”

FUTURE
We Analyzed 16,625 Papers to Figure Out Where AI Is Headed Next
Karen Hao | MIT Technology Review
“…though deep learning has singlehandedly thrust AI into the public eye, it represents just a small blip in the history of humanity’s quest to replicate our own intelligence. It’s been at the forefront of that effort for less than 10 years. When you zoom out on the whole history of the field, it’s easy to realize that it could soon be on its way out.”

COMPUTING
Apple’s Finger-Controller Patent Is a Glimpse at Mixed Reality’s Future
Mark Sullivan | Fast Company
“[Apple’s] engineers are now looking past the phone touchscreen toward mixed reality, where the company’s next great UX will very likely be built. A recent patent application gives some tantalizing clues as to how Apple’s people are thinking about aspects of that challenge.”

GOVERNANCE
How Do You Govern Machines That Can Learn? Policymakers Are Trying to Figure That Out
Steve Lohr | The New York Times
“Regulation is coming. That’s a good thing. Rules of competition and behavior are the foundation of healthy, growing markets. That was the consensus of the policymakers at MIT. But they also agreed that artificial intelligence raises some fresh policy challenges.”

Image Credit: Victoria Shapiro / Shutterstock.com Continue reading →

Posted in Human Robots

#434534 To Extend Our Longevity, First We Must ...

Posted on January 25, 2019 by Android

Healthcare today is reactive, retrospective, bureaucratic, and expensive. It’s sick care, not healthcare.

But that is radically changing at an exponential rate.

Through this multi-part blog series on longevity, I’ll take a deep dive into aging, longevity, and healthcare technologies that are working together to dramatically extend the human lifespan, disrupting the $3 trillion healthcare system in the process.

I’ll begin the series by explaining the nine hallmarks of aging, as explained in this journal article. Next, I’ll break down the emerging technologies and initiatives working to combat these nine hallmarks. Finally, I’ll explore the transformative implications of dramatically extending the human health span.

In this blog I’ll cover:

Why the healthcare system is broken
Why, despite this, we live in the healthiest time in human history
The nine mechanisms of aging

Let’s dive in.

The System is Broken—Here’s the Data:

Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability.
Americans spend, on average, $8,915 per person on healthcare—more than any other country on Earth.
Prescription drugs cost around 50 percent more in the US than in other industrialized countries.
At current rates, by 2025, nearly 25 percent of the US GDP will be spent on healthcare.
It takes 12 years and $359 million, on average, to take a new drug from the lab to a patient.
Only 5 in 5,000 of these new drugs proceed to human testing. From there, only 1 of those 5 is actually approved for human use.

And Yet, We Live in the Healthiest Time in Human History
Consider these insights, which I adapted from Max Roser’s excellent database Our World in Data:

Right now, the countries with the lowest life expectancy in the world still have higher life expectancies than the countries with the highest life expectancy did in 1800.
In 1841, a 5-year-old had a life expectancy of 55 years. Today, a 5-year-old can expect to live 82 years—an increase of 27 years.
We’re seeing a dramatic increase in healthspan. In 1845, a newborn would expect to live to 40 years old. For a 70-year-old, that number became 79. Now, people of all ages can expect to live to be 81 to 86 years old.
100 years ago, 1 of 3 children would die before the age of 5. As of 2015, the child mortality rate fell to just 4.3 percent.
The cancer mortality rate has declined 27 percent over the past 25 years.

Figure: Around the globe, life expectancy has doubled since the 1800s. | Image from Life Expectancy by Max Roser – Our World in Data / CC BY SA
Figure: A dramatic reduction in child mortality in 1800 vs. in 2015. | Image from Child Mortality by Max Roser – Our World in Data / CC BY SA
The 9 Mechanisms of Aging
*This section was adapted from CB INSIGHTS: The Future Of Aging.

Longevity, healthcare, and aging are intimately linked.

With better healthcare, we can better treat some of the leading causes of death, impacting how long we live.

By investigating how to treat diseases, we’ll inevitably better understand what causes these diseases in the first place, which directly correlates to why we age.

Following are the nine hallmarks of aging. I’ll share examples of health and longevity technologies addressing each of these later in this blog series.

Genomic instability: As we age, the environment and normal cellular processes cause damage to our genes. Activities like flying at high altitude, for example, expose us to increased radiation or free radicals. This damage compounds over the course of life and is known to accelerate aging.
Telomere attrition: Each strand of DNA in the body (known as chromosomes) is capped by telomeres. These short snippets of DNA repeated thousands of times are designed to protect the bulk of the chromosome. Telomeres shorten as our DNA replicates; if a telomere reaches a certain critical shortness, a cell will stop dividing, resulting in increased incidence of disease.
Epigenetic alterations: Over time, environmental factors will change how genes are expressed, i.e., how certain sequences of DNA are read and the instruction set implemented.
Loss of proteostasis: Over time, different proteins in our body will no longer fold and function as they are supposed to, resulting in diseases ranging from cancer to neurological disorders.
Deregulated nutrient-sensing: Nutrient levels in the body can influence various metabolic pathways. Among the affected parts of these pathways are proteins like IGF-1, mTOR, sirtuins, and AMPK. Changing levels of these proteins’ pathways has implications on longevity.
Mitochondrial dysfunction: Mitochondria (our cellular power plants) begin to decline in performance as we age. Decreased performance results in excess fatigue and other symptoms of chronic illnesses associated with aging.
Cellular senescence: As cells age, they stop dividing and cannot be removed from the body. They build up and typically cause increased inflammation.
Stem cell exhaustion: As we age, our supply of stem cells begins to diminish as much as 100 to 10,000-fold in different tissues and organs. In addition, stem cells undergo genetic mutations, which reduce their quality and effectiveness at renovating and repairing the body.
Altered intercellular communication: The communication mechanisms that cells use are disrupted as cells age, resulting in decreased ability to transmit information between cells.

Conclusion
Over the past 200 years, we have seen an abundance of healthcare technologies enable a massive lifespan boom.

Now, exponential technologies like artificial intelligence, 3D printing and sensors, as well as tremendous advancements in genomics, stem cell research, chemistry, and many other fields, are beginning to tackle the fundamental issues of why we age.

In the next blog in this series, we will dive into how genome sequencing and editing, along with new classes of drugs, are augmenting our biology to further extend our healthy lives.

What will you be able to achieve with an extra 30 to 50 healthy years (or longer) in your lifespan? Personally, I’m excited for a near-infinite lifespan to take on moonshots.

Join Me
Abundance-Digital Online Community: I’ve created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is my ‘onramp’ for exponential entrepreneurs – those who want to get involved and play at a higher level. Click here to learn more.

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Posted in Human Robots

#434492 Black Mirror’s ‘Bandersnatch’ ...

Posted on January 20, 2019 by Android

When was the last time you watched a movie where you could control the plot?

Bandersnatch is the first interactive film in the sci fi anthology series Black Mirror. Written by series creator Charlie Brooker and directed by David Slade, the film tells the story of young programmer Stefan Butler, who is adapting a fantasy choose-your-own-adventure novel called Bandersnatch into a video game. Throughout the film, viewers are given the power to influence Butler’s decisions, leading to diverging plots with different endings.

Like many Black Mirror episodes, this film is mind-bending, dark, and thought-provoking. In addition to innovating cinema as we know it, it is a fascinating rumination on free will, parallel realities, and emerging technologies.

Pick Your Own Adventure
With a non-linear script, Bandersnatch is a viewing experience like no other. Throughout the film viewers are given the option of making a decision for the protagonist. In these instances, they have 10 seconds to make a decision until a default decision is made. For example, in the early stage of the plot, Butler is given the choice of accepting or rejecting Tuckersoft’s offer to develop a video game and the viewer gets to decide what he does. The decision then shapes the plot accordingly.

The video game Butler is developing involves moving through a graphical maze of corridors while avoiding a creature called the Pax, and at times making choices through an on-screen instruction (sound familiar?). In other words, it’s a pick-your-own-adventure video game in a pick-your-own-adventure movie.

Many viewers have ended up spending hours exploring all the different branches of the narrative (though the average viewing is 90 minutes). One user on reddit has mapped out an entire flowchart, showing how all the different decisions (and pseudo-decisions) lead to various endings.

However, over time, Butler starts to question his own free will. It’s almost as if he’s beginning to realize that the audience is controlling him. In one branch of the narrative, he is confronted by this reality when the audience indicates to him that he is being controlled in a Netflix show: “I am watching you on Netflix. I make all the decisions for you”. Butler, as you can imagine, is horrified by this message.

But Butler isn’t the only one who has an illusion of choice. We, the seemingly powerful viewers, also appear to operate under the illusion of choice. Despite there being five main endings to the film, they are all more or less the same.

The Science Behind Bandersnatch
The premise of Bandersnatch isn’t based on fantasy, but hard science. Free will has always been a widely-debated issue in neuroscience, with reputable scientists and studies demonstrating that the whole concept may be an illusion.

In the 1970s, a psychologist named Benjamin Libet conducted a series of experiments that studied voluntary decision making in humans. He found that brain activity imitating an action, such as moving your wrist, preceded the conscious awareness of the action.

Psychologist Malcom Gladwell theorizes that while we like to believe we spend a lot of time thinking about our decisions, our mental processes actually work rapidly, automatically, and often subconsciously, from relatively little information. In addition to this, thinking and making decisions are usually a byproduct of several different brain systems, such as the hippocampus, amygdala, and prefrontal cortex working together. You are more conscious of some information processes in the brain than others.

As neuroscientist and philosopher Sam Harris points out in his book Free Will, “You did not pick your parents or the time and place of your birth. You didn’t choose your gender or most of your life experiences. You had no control whatsoever over your genome or the development of your brain. And now your brain is making choices on the basis of preferences and beliefs that have been hammered into it over a lifetime.” Like Butler, we may believe we are operating under full agency of our abilities, but we are at the mercy of many internal and external factors that influence our decisions.

Beyond free will, Bandersnatch also taps into the theory of parallel universes, a facet of the astronomical theory of the multiverse. In astrophysics, there is a theory that there are parallel universes other than our own, where all the choices you made are played out in alternate realities. For instance, if today you had the option of having cereal or eggs for breakfast, and you chose eggs, in a parallel universe, you chose cereal. Human history and our lives may have taken different paths in these parallel universes.

The Future of Cinema
In the future, the viewing experience will no longer be a passive one. Bandersnatch is just a glimpse into how technology is revolutionizing film as we know it and making it a more interactive and personalized experience. All the different scenarios and branches of the plot were scripted and filmed, but in the future, they may be adapted real-time via artificial intelligence.

Virtual reality may allow us to play an even more active role by making us participants or characters in the film. Data from your history of preferences and may be used to create a unique version of the plot that is optimized for your viewing experience.

Let’s also not underestimate the social purpose of advancing film and entertainment. Science fiction gives us the ability to create simulations of the future. Different narratives can allow us to explore how powerful technologies combined with human behavior can result in positive or negative scenarios. Perhaps in the future, science fiction will explore implications of technologies and observe human decision making in novel contexts, via AI-powered films in the virtual world.

Image Credit: andrey_l / Shutterstock.com

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Posted in Human Robots

#434324 Big Brother Nation: The Case for ...

Posted on January 13, 2019 by Android

Powerful surveillance cameras have crept into public spaces. We are filmed and photographed hundreds of times a day. To further raise the stakes, the resulting video footage is fed to new forms of artificial intelligence software that can recognize faces in real time, read license plates, even instantly detect when a particular pre-defined action or activity takes place in front of a camera.

As most modern cities have quietly become surveillance cities, the law has been slow to catch up. While we wait for robust legal frameworks to emerge, the best way to protect our civil liberties right now is to fight technology with technology. All cities should place local surveillance video into a public cloud-based data trust. Here’s how it would work.

In Public Data We Trust
To democratize surveillance, every city should implement three simple rules. First, anyone who aims a camera at public space must upload that day’s haul of raw video file (and associated camera meta-data) into a cloud-based repository. Second, this cloud-based repository must have open APIs and a publicly-accessible log file that records search histories and tracks who has accessed which video files. And third, everyone in the city should be given the same level of access rights to the stored video data—no exceptions.

This kind of public data repository is called a “data trust.” Public data trusts are not just wishful thinking. Different types of trusts are already in successful use in Estonia and Barcelona, and have been proposed as the best way to store and manage the urban data that will be generated by Alphabet’s planned Sidewalk Labs project in Toronto.

It’s true that few people relish the thought of public video footage of themselves being looked at by strangers and friends, by ex-spouses, potential employers, divorce attorneys, and future romantic prospects. In fact, when I propose this notion when I give talks about smart cities, most people recoil in horror. Some turn red in the face and jeer at my naiveté. Others merely blink quietly in consternation.

The reason we should take this giant step towards extreme transparency is to combat the secrecy that surrounds surveillance. Openness is a powerful antidote to oppression. Edward Snowden summed it up well when he said, “Surveillance is not about public safety, it’s about power. It’s about control.”

Let Us Watch Those Watching Us
If public surveillance video were put back into the hands of the people, citizens could watch their government as it watches them. Right now, government cameras are controlled by the state. Camera locations are kept secret, and only the agencies that control the cameras get to see the footage they generate.

Because of these information asymmetries, civilians have no insight into the size and shape of the modern urban surveillance infrastructure that surrounds us, nor the uses (or abuses) of the video footage it spawns. For example, there is no swift and efficient mechanism to request a copy of video footage from the cameras that dot our downtown. Nor can we ask our city’s police force to show us a map that documents local traffic camera locations.

By exposing all public surveillance videos to the public gaze, cities could give regular people tools to assess the size, shape, and density of their local surveillance infrastructure and neighborhood “digital dragnet.” Using the meta-data that’s wrapped around video footage, citizens could geo-locate individual cameras onto a digital map to generate surveillance “heat maps.” This way people could assess whether their city’s camera density was higher in certain zip codes, or in neighborhoods populated by a dominant ethnic group.

Surveillance heat maps could be used to document which government agencies were refusing to upload their video files, or which neighborhoods were not under surveillance. Given what we already know today about the correlation between camera density, income, and social status, these “dark” camera-free regions would likely be those located near government agencies and in more affluent parts of a city.

Extreme transparency would democratize surveillance. Every city’s data trust would keep a publicly-accessible log of who’s searching for what, and whom. People could use their local data trust’s search history to check whether anyone was searching for their name, face, or license plate. As a result, clandestine spying on—and stalking of—particular individuals would become difficult to hide and simpler to prove.

Protect the Vulnerable and Exonerate the Falsely Accused
Not all surveillance video automatically works against the underdog. As the bungled (and consequently no longer secret) assassination of journalist Jamal Khashoggi demonstrated, one of the unexpected upsides of surveillance cameras has been the fact that even kings become accountable for their crimes. If opened up to the public, surveillance cameras could serve as witnesses to justice.

Video evidence has the power to protect vulnerable individuals and social groups by shedding light onto messy, unreliable (and frequently conflicting) human narratives of who did what to whom, and why. With access to a data trust, a person falsely accused of a crime could prove their innocence. By searching for their own face in video footage or downloading time/date stamped footage from a particular camera, a potential suspect could document their physical absence from the scene of a crime—no lengthy police investigation or high-priced attorney needed.

Given Enough Eyeballs, All Crimes Are Shallow
Placing public surveillance video into a public trust could make cities safer and would streamline routine police work. Linus Torvalds, the developer of open-source operating system Linux, famously observed that “given enough eyeballs, all bugs are shallow.” In the case of public cameras and a common data repository, Torvald’s Law could be restated as “given enough eyeballs, all crimes are shallow.”

If thousands of citizen eyeballs were given access to a city’s public surveillance videos, local police forces could crowdsource the work of solving crimes and searching for missing persons. Unfortunately, at the present time, cities are unable to wring any social benefit from video footage of public spaces. The most formidable barrier is not government-imposed secrecy, but the fact that as cameras and computers have grown cheaper, a large and fast-growing “mom and pop” surveillance state has taken over most of the filming of public spaces.

While we fear spooky government surveillance, the reality is that we’re much more likely to be filmed by security cameras owned by shopkeepers, landlords, medical offices, hotels, homeowners, and schools. These businesses, organizations, and individuals install cameras in public areas for practical reasons—to reduce their insurance costs, to prevent lawsuits, or to combat shoplifting. In the absence of regulations governing their use, private camera owners store video footage in a wide variety of locations, for varying retention periods.

The unfortunate (and unintended) result of this informal and decentralized network of public surveillance is that video files are not easy to access, even for police officers on official business. After a crime or terrorist attack occurs, local police (or attorneys armed with a subpoena) go from door to door to manually collect video evidence. Once they have the videos in hand, their next challenge is searching for the right “codex” to crack the dozens of different file formats they encounter so they can watch and analyze the footage.

The result of these practical barriers is that as it stands today, only people with considerable legal or political clout are able to successfully gain access into a city’s privately-owned, ad-hoc collections of public surveillance videos. Not only are cities missing the opportunity to streamline routine evidence-gathering police work, they’re missing a radically transformative benefit that would become possible once video footage from thousands of different security cameras were pooled into a single repository: the ability to apply the power of citizen eyeballs to the work of improving public safety.

Why We Need Extreme Transparency
When regular people can’t access their own surveillance videos, there can be no data justice. While we wait for the law to catch up with the reality of modern urban life, citizens and city governments should use technology to address the problem that lies at the heart of surveillance: a power imbalance between those who control the cameras and those who don’t.

Cities should permit individuals and organizations to install and deploy as many public-facing cameras as they wish, but with the mandate that camera owners must place all resulting video footage into the mercilessly bright sunshine of an open data trust. This way, cloud computing, open APIs, and artificial intelligence software can help combat abuses of surveillance and give citizens insight into who’s filming us, where, and why.

Image Credit: VladFotoMag / Shutterstock.com Continue reading →

Posted in Human Robots

#434235 The Milestones of Human Progress We ...

Posted on December 27, 2018 by Android

When you look back at 2018, do you see a good or a bad year? Chances are, your perception of the year involves fixating on all the global and personal challenges it brought. In fact, every year, we tend to look back at the previous year as “one of the most difficult” and hope that the following year is more exciting and fruitful.

But in the grander context of human history, 2018 was an extraordinarily positive year. In fact, every year has been getting progressively better.

Before we dive into some of the highlights of human progress from 2018, let’s make one thing clear. There is no doubt that there are many overwhelming global challenges facing our species. From climate change to growing wealth inequality, we are far from living in a utopia.

Yet it’s important to recognize that both our news outlets and audiences have been disproportionately fixated on negative news. This emphasis on bad news is detrimental to our sense of empowerment as a species.

So let’s take a break from all the disproportionate negativity and have a look back on how humanity pushed boundaries in 2018.

On Track to Becoming an Interplanetary Species
We often forget how far we’ve come since the very first humans left the African savanna, populated the entire planet, and developed powerful technological capabilities. Our desire to explore the unknown has shaped the course of human evolution and will continue to do so.

This year, we continued to push the boundaries of space exploration. As depicted in the enchanting short film Wanderers, humanity’s destiny is the stars. We are born to be wanderers of the cosmos and the everlasting unknown.

SpaceX had 21 successful launches in 2018 and closed the year with a successful GPS launch. The latest test flight by Virgin Galactic was also an incredible milestone, as SpaceShipTwo was welcomed into space. Richard Branson and his team expect that space tourism will be a reality within the next 18 months.

Our understanding of the cosmos is also moving forward with continuous breakthroughs in astrophysics and astronomy. One notable example is the MARS InSight Mission, which uses cutting-edge instruments to study Mars’ interior structure and has even given us the first recordings of sound on Mars.

Understanding and Tackling Disease
Thanks to advancements in science and medicine, we are currently living longer, healthier, and wealthier lives than at any other point in human history. In fact, for most of human history, life expectancy at birth was around 30. Today it is more than 70 worldwide, and in the developed parts of the world, more than 80.

Brilliant researchers around the world are pushing for even better health outcomes. This year, we saw promising treatments emerge against Alzheimers disease, rheumatoid arthritis, multiple scleroris, and even the flu.

The deadliest disease of them all, cancer, is also being tackled. According to the American Association of Cancer Research, 22 revolutionary treatments for cancer were approved in the last year, and the death rate in adults is also in decline. Advancements in immunotherapy, genetic engineering, stem cells, and nanotechnology are all powerful resources to tackle killer diseases.

Breakthrough Mental Health Therapy
While cleaner energy, access to education, and higher employment rates can improve quality of life, they do not guarantee happiness and inner peace. According to the World Economic Forum, mental health disorders affect one in four people globally, and in many places they are significantly under-reported. More people are beginning to realize that our mental health is just as important as our physical health, and that we ought to take care of our minds just as much as our bodies.

We are seeing the rise of applications that put mental well-being at their center. Breakthrough advancements in genetics are allowing us to better understand the genetic makeup of disorders like clinical depression or Schizophrenia, and paving the way for personalized medical treatment. We are also seeing the rise of increasingly effective therapeutic treatments for anxiety.

This year saw many milestones for a whole new revolutionary area in mental health: psychedelic therapy. Earlier this summer, the FDA granted breakthrough therapy designation to MDMA for the treatment of PTSD, after several phases of successful trails. Similar research has discovered that Psilocybin (also known as magic mushrooms) combined with therapy is far more effective than traditional forms of treatment for depression and anxiety.

Moral and Social Progress
Innovation is often associated with economic and technological progress. However, we also need leaps of progress in our morality, values, and policies. Throughout the 21st century, we’ve made massive strides in rights for women and children, civil rights, LGBT rights, animal rights, and beyond. However, with rising nationalism and xenophobia in many parts of the developed world, there is significant work to be done on this front.

All hope is not lost, as we saw many noteworthy milestones this year. In January 2018, Iceland introduced the equal wage law, bringing an end to the gender wage gap. On September 6th, the Indian Supreme Court decriminalized homosexuality, marking a historical moment. Earlier in December, the European Commission released a draft of ethics guidelines for trustworthy artificial intelligence. Such are just a few examples of positive progress in social justice, ethics, and policy.

We are also seeing a global rise in social impact entrepreneurship. Emerging startups are no longer valued simply based on their profits and revenue, but also on the level of positive impact they are having on the world at large. The world’s leading innovators are not asking themselves “How can I become rich?” but rather “How can I solve this global challenge?”

Intelligently Optimistic for 2019
It’s becoming more and more clear that we are living in the most exciting time in human history. Even more, we mustn’t be afraid to be optimistic about 2019.

An optimistic mindset can be grounded in rationality and evidence. Intelligent optimism is all about being excited about the future in an informed and rational way. The mindset is critical if we are to get everyone excited about the future by highlighting the rapid progress we have made and recognizing the tremendous potential humans have to find solutions to our problems.

In his latest TED talk, Steven Pinker points out, “Progress does not mean that everything becomes better for everyone everywhere all the time. That would be a miracle, and progress is not a miracle but problem-solving. Problems are inevitable and solutions create new problems which have to be solved in their turn.”

Let us not forget that in cosmic time scales, our entire species’ lifetime, including all of human history, is the equivalent of the blink of an eye. The probability of us existing both as an intelligent species and as individuals is so astoundingly low that it’s practically non-existent. We are the products of 14 billion years of cosmic evolution and extraordinarily good fortune. Let’s recognize and leverage this wondrous opportunity, and pave an exciting way forward.

Image Credit: Virgin Galactic / Virgin Galactic 2018. Continue reading →

Posted in Human Robots