Tag Archives: health

#435614 3 Easy Ways to Evaluate AI Claims

When every other tech startup claims to use artificial intelligence, it can be tough to figure out if an AI service or product works as advertised. In the midst of the AI “gold rush,” how can you separate the nuggets from the fool’s gold?

There’s no shortage of cautionary tales involving overhyped AI claims. And applying AI technologies to health care, education, and law enforcement mean that getting it wrong can have real consequences for society—not just for investors who bet on the wrong unicorn.

So IEEE Spectrum asked experts to share their tips for how to identify AI hype in press releases, news articles, research papers, and IPO filings.

“It can be tricky, because I think the people who are out there selling the AI hype—selling this AI snake oil—are getting more sophisticated over time,” says Tim Hwang, director of the Harvard-MIT Ethics and Governance of AI Initiative.

The term “AI” is perhaps most frequently used to describe machine learning algorithms (and deep learning algorithms, which require even less human guidance) that analyze huge amounts of data and make predictions based on patterns that humans might miss. These popular forms of AI are mostly suited to specialized tasks, such as automatically recognizing certain objects within photos. For that reason, they are sometimes described as “weak” or “narrow” AI.

Some researchers and thought leaders like to talk about the idea of “artificial general intelligence” or “strong AI” that has human-level capacity and flexibility to handle many diverse intellectual tasks. But for now, this type of AI remains firmly in the realm of science fiction and is far from being realized in the real world.

“AI has no well-defined meaning and many so-called AI companies are simply trying to take advantage of the buzz around that term,” says Arvind Narayanan, a computer scientist at Princeton University. “Companies have even been caught claiming to use AI when, in fact, the task is done by human workers.”

Here are three ways to recognize AI hype.

Look for Buzzwords
One red flag is what Hwang calls the “hype salad.” This means stringing together the term “AI” with many other tech buzzwords such as “blockchain” or “Internet of Things.” That doesn’t automatically disqualify the technology, but spotting a high volume of buzzwords in a post, pitch, or presentation should raise questions about what exactly the company or individual has developed.

Other experts agree that strings of buzzwords can be a red flag. That’s especially true if the buzzwords are never really explained in technical detail, and are simply tossed around as vague, poorly-defined terms, says Marzyeh Ghassemi, a computer scientist and biomedical engineer at the University of Toronto in Canada.

“I think that if it looks like a Google search—picture ‘interpretable blockchain AI deep learning medicine’—it's probably not high-quality work,” Ghassemi says.

Hwang also suggests mentally replacing all mentions of “AI” in an article with the term “magical fairy dust.” It’s a way of seeing whether an individual or organization is treating the technology like magic. If so—that’s another good reason to ask more questions about what exactly the AI technology involves.

And even the visual imagery used to illustrate AI claims can indicate that an individual or organization is overselling the technology.

“I think that a lot of the people who work on machine learning on a day-to-day basis are pretty humble about the technology, because they’re largely confronted with how frequently it just breaks and doesn't work,” Hwang says. “And so I think that if you see a company or someone representing AI as a Terminator head, or a big glowing HAL eye or something like that, I think it’s also worth asking some questions.”

Interrogate the Data

It can be hard to evaluate AI claims without any relevant expertise, says Ghassemi at the University of Toronto. Even experts need to know the technical details of the AI algorithm in question and have some access to the training data that shaped the AI model’s predictions. Still, savvy readers with some basic knowledge of applied statistics can search for red flags.

To start, readers can look for possible bias in training data based on small sample sizes or a skewed population that fails to reflect the broader population, Ghassemi says. After all, an AI model trained only on health data from white men would not necessarily achieve similar results for other populations of patients.

“For me, a red flag is not demonstrating deep knowledge of how your labels are defined.”
—Marzyeh Ghassemi, University of Toronto

How machine learning and deep learning models perform also depends on how well humans labeled the sample datasets use to train these programs. This task can be straightforward when labeling photos of cats versus dogs, but gets more complicated when assigning disease diagnoses to certain patient cases.

Medical experts frequently disagree with each other on diagnoses—which is why many patients seek a second opinion. Not surprisingly, this ambiguity can also affect the diagnostic labels that experts assign in training datasets. “For me, a red flag is not demonstrating deep knowledge of how your labels are defined,” Ghassemi says.

Such training data can also reflect the cultural stereotypes and biases of the humans who labeled the data, says Narayanan at Princeton University. Like Ghassemi, he recommends taking a hard look at exactly what the AI has learned: “A good way to start critically evaluating AI claims is by asking questions about the training data.”

Another red flag is presenting an AI system’s performance through a single accuracy figure without much explanation, Narayanan says. Claiming that an AI model achieves “99 percent” accuracy doesn’t mean much without knowing the baseline for comparison—such as whether other systems have already achieved 99 percent accuracy—or how well that accuracy holds up in situations beyond the training dataset.

Narayanan also emphasized the need to ask questions about an AI model’s false positive rate—the rate of making wrong predictions about the presence of a given condition. Even if the false positive rate of a hypothetical AI service is just one percent, that could have major consequences if that service ends up screening millions of people for cancer.

Readers can also consider whether using AI in a given situation offers any meaningful improvement compared to traditional statistical methods, says Clayton Aldern, a data scientist and journalist who serves as managing director for Caldern LLC. He gave the hypothetical example of a “super-duper-fancy deep learning model” that achieves a prediction accuracy of 89 percent, compared to a “little polynomial regression model” that achieves 86 percent on the same dataset.

“We're talking about a three-percentage-point increase on something that you learned about in Algebra 1,” Aldern says. “So is it worth the hype?”

Don’t Ignore the Drawbacks

The hype surrounding AI isn’t just about the technical merits of services and products driven by machine learning. Overblown claims about the beneficial impacts of AI technology—or vague promises to address ethical issues related to deploying it—should also raise red flags.

“If a company promises to use its tech ethically, it is important to question if its business model aligns with that promise,” Narayanan says. “Even if employees have noble intentions, it is unrealistic to expect the company as a whole to resist financial imperatives.”

One example might be a company with a business model that depends on leveraging customers’ personal data. Such companies “tend to make empty promises when it comes to privacy,” Narayanan says. And, if companies hire workers to produce training data, it’s also worth asking whether the companies treat those workers ethically.

The transparency—or lack thereof—about any AI claim can also be telling. A company or research group can minimize concerns by publishing technical claims in peer-reviewed journals or allowing credible third parties to evaluate their AI without giving away big intellectual property secrets, Narayanan says. Excessive secrecy is a big red flag.

With these strategies, you don’t need to be a computer engineer or data scientist to start thinking critically about AI claims. And, Narayanan says, the world needs many people from different backgrounds for societies to fully consider the real-world implications of AI.

Editor’s Note: The original version of this story misspelled Clayton Aldern’s last name as Alderton. Continue reading

Posted in Human Robots

#435528 The Time for AI Is Now. Here’s Why

You hear a lot these days about the sheer transformative power of AI.

There’s pure intelligence: DeepMind’s algorithms readily beat humans at Go and StarCraft, and DeepStack triumphs over humans at no-limit hold’em poker. Often, these silicon brains generate gameplay strategies that don’t resemble anything from a human mind.

There’s astonishing speed: algorithms routinely surpass radiologists in diagnosing breast cancer, eye disease, and other ailments visible from medical imaging, essentially collapsing decades of expert training down to a few months.

Although AI’s silent touch is mainly felt today in the technological, financial, and health sectors, its impact across industries is rapidly spreading. At the Singularity University Global Summit in San Francisco this week Neil Jacobstein, Chair of AI and Robotics, painted a picture of a better AI-powered future for humanity that is already here.

Thanks to cloud-based cognitive platforms, sophisticated AI tools like deep learning are no longer relegated to academic labs. For startups looking to tackle humanity’s grand challenges, the tools to efficiently integrate AI into their missions are readily available. The progress of AI is massively accelerating—to the point you need help from AI to track its progress, joked Jacobstein.

Now is the time to consider how AI can impact your industry, and in the process, begin to envision a beneficial relationship with our machine coworkers. As Jacobstein stressed in his talk, the future of a brain-machine mindmeld is a collaborative intelligence that augments our own. “AI is reinventing the way we invent,” he said.

AI’s Rapid Revolution
Machine learning and other AI-based methods may seem academic and abstruse. But Jacobstein pointed out that there are already plenty of real-world AI application frameworks.

Their secret? Rather than coding from scratch, smaller companies—with big visions—are tapping into cloud-based solutions such as Google’s TensorFlow, Microsoft’s Azure, or Amazon’s AWS to kick off their AI journey. These platforms act as all-in-one solutions that not only clean and organize data, but also contain built-in security and drag-and-drop coding that allow anyone to experiment with complicated machine learning algorithms.

Google Cloud’s Anthos, for example, lets anyone migrate data from other servers—IBM Watson or AWS, for example—so users can leverage different computing platforms and algorithms to transform data into insights and solutions.

Rather than coding from scratch, it’s already possible to hop onto a platform and play around with it, said Jacobstein. That’s key: this democratization of AI is how anyone can begin exploring solutions to problems we didn’t even know we had, or those long thought improbable.

The acceleration is only continuing. Much of AI’s mind-bending pace is thanks to a massive infusion of funding. Microsoft recently injected $1 billion into OpenAI, the Elon Musk venture that engineers socially responsible artificial general intelligence (AGI).

The other revolution is in hardware, and Google, IBM, and NVIDIA—among others—are racing to manufacture computing chips tailored to machine learning.

Democratizing AI is like the birth of the printing press. Mechanical printing allowed anyone to become an author; today, an iPhone lets anyone film a movie masterpiece.

However, this diffusion of AI into the fabric of our lives means tech explorers need to bring skepticism to their AI solutions, giving them a dose of empathy, nuance, and humanity.

A Path Towards Ethical AI
The democratization of AI is a double-edged sword: as more people wield the technology’s power in real-world applications, problems embedded in deep learning threaten to disrupt those very judgment calls.

Much of the press on the dangers of AI focuses on superintelligence—AI that’s more adept at learning than humans—taking over the world, said Jacobstein. But the near-term threat, and far more insidious, is in humans misusing the technology.

Deepfakes, for example, allow AI rookies to paste one person’s head on a different body or put words into a person’s mouth. As the panel said, it pays to think of AI as a cybersecurity problem, one with currently shaky accountability and complexity, and one that fails at diversity and bias.

Take bias. Thanks to progress in natural language processing, Google Translate works nearly perfectly today, so much so that many consider the translation problem solved. Not true, the panel said. One famous example is how the algorithm translates gender-neutral terms like “doctor” into “he” and “nurse” into “she.”

These biases reflect our own, and it’s not just a data problem. To truly engineer objective AI systems, ones stripped of our society’s biases, we need to ask who is developing these systems, and consult those who will be impacted by the products. In addition to gender, racial bias is also rampant. For example, one recent report found that a supposedly objective crime-predicting system was trained on falsified data, resulting in outputs that further perpetuate corrupt police practices. Another study from Google just this month found that their hate speech detector more often labeled innocuous tweets from African-Americans as “obscene” compared to tweets from people of other ethnicities.

We often think of building AI as purely an engineering job, the panelists agreed. But similar to gene drives, germ-line genome editing, and other transformative—but dangerous—tools, AI needs to grow under the consultation of policymakers and other stakeholders. It pays to start young: educating newer generations on AI biases will mold malleable minds early, alerting them to the problem of bias and potentially mitigating risks.

As panelist Tess Posner from AI4ALL said, AI is rocket fuel for ambition. If young minds set out using the tools of AI to tackle their chosen problems, while fully aware of its inherent weaknesses, we can begin to build an AI-embedded future that is widely accessible and inclusive.

The bottom line: people who will be impacted by AI need to be in the room at the conception of an AI solution. People will be displaced by the new technology, and ethical AI has to consider how to mitigate human suffering during the transition. Just because AI looks like “magic fairy dust doesn’t mean that you’re home free,” the panelists said. You, the sentient human, bear the burden of being responsible for how you decide to approach the technology.

The time for AI is now. Let’s make it ethical.

Image Credit: GrAI / Shutterstock.com Continue reading

Posted in Human Robots

#435522 Harvard’s Smart Exo-Shorts Talk to the ...

Exosuits don’t generally scream “fashionable” or “svelte.” Take the mind-controlled robotic exoskeleton that allowed a paraplegic man to kick off the World Cup back in 2014. Is it cool? Hell yeah. Is it practical? Not so much.

Yapping about wearability might seem childish when the technology already helps people with impaired mobility move around dexterously. But the lesson of the ill-fated Google Glassholes, which includes an awkward dorky head tilt and an assuming voice command, clearly shows that wearable computer assistants can’t just work technologically—they have to look natural and allow the user to behave like as usual. They have to, in a sense, disappear.

To Dr. Jose Pons at the Legs + Walking Ability Lab in Chicago, exosuits need three main selling points to make it in the real world. One, they have to physically interact with their wearer and seamlessly deliver assistance when needed. Two, they should cognitively interact with the host to guide and control the robot at all times. Finally, they need to feel like a second skin—move with the user without adding too much extra mass or reducing mobility.

This week, a US-Korean collaboration delivered the whole shebang in a Lululemon-style skin-hugging package combined with a retro waist pack. The portable exosuit, weighing only 11 pounds, looks like a pair of spandex shorts but can support the wearer’s hip movement when needed. Unlike their predecessors, the shorts are embedded with sensors that let them know when the wearer is walking versus running by analyzing gait.

Switching between the two movement modes may not seem like much, but what naturally comes to our brains doesn’t translate directly to smart exosuits. “Walking and running have fundamentally different biomechanics, which makes developing devices that assist both gaits challenging,” the team said. Their algorithm, computed in the cloud, allows the wearer to easily switch between both, with the shorts providing appropriate hip support that makes the movement experience seamless.

To Pons, who was not involved in the research but wrote a perspective piece, the study is an exciting step towards future exosuits that will eventually disappear under the skin—that is, implanted neural interfaces to control robotic assistance or activate the user’s own muscles.

“It is realistic to think that we will witness, in the next several years…robust human-robot interfaces to command wearable robotics based on…the neural code of movement in humans,” he said.

A “Smart” Exosuit Hack
There are a few ways you can hack a human body to move with an exosuit. One is using implanted electrodes inside the brain or muscles to decipher movement intent. With heavy practice, a neural implant can help paralyzed people walk again or dexterously move external robotic arms. But because the technique requires surgery, it’s not an immediate sell for people who experience low mobility because of aging or low muscle tone.

The other approach is to look to biophysics. Rather than decoding neural signals that control movement, here the idea is to measure gait and other physical positions in space to decipher intent. As you can probably guess, accurately deciphering user intent isn’t easy, especially when the wearable tries to accommodate multiple gaits. But the gains are many: there’s no surgery involved, and the wearable is low in energy consumption.

Double Trouble
The authors decided to tackle an everyday situation. You’re walking to catch the train to work, realize you’re late, and immediately start sprinting.

That seemingly easy conversion hides a complex switch in biomechanics. When you walk, your legs act like an inverted pendulum that swing towards a dedicated center in a predictable way. When you run, however, the legs move more like a spring-loaded system, and the joints involved in the motion differ from a casual stroll. Engineering an assistive wearable for each is relatively simple; making one for both is exceedingly hard.

Led by Dr. Conor Walsh at Harvard University, the team started with an intuitive idea: assisted walking and running requires specialized “actuation” profiles tailored to both. When the user is moving in a way that doesn’t require assistance, the wearable needs to be out of the way so that it doesn’t restrict mobility. A quick analysis found that assisting hip extension has the largest impact, because it’s important to both gaits and doesn’t add mass to the lower legs.

Building on that insight, the team made a waist belt connected to two thigh wraps, similar to a climbing harness. Two electrical motors embedded inside the device connect the waist belt to other components through a pulley system to help the hip joints move. The whole contraption weighed about 11 lbs and didn’t obstruct natural movement.

Next, the team programmed two separate supporting profiles for walking and running. The goal was to reduce the “metabolic cost” for both movements, so that the wearer expends as little energy as needed. To switch between the two programs, they used a cloud-based classification algorithm to measure changes in energy fluctuation to figure out what mode—running or walking—the user is in.

Smart Booster
Initial trials on treadmills were highly positive. Six male volunteers with similar age and build donned the exosuit and either ran or walked on the treadmill at varying inclines. The algorithm performed perfectly at distinguishing between the two gaits in all conditions, even at steep angles.

An outdoor test with eight volunteers also proved the algorithm nearly perfect. Even on uneven terrain, only two steps out of all test trials were misclassified. In an additional trial on mud or snow, the algorithm performed just as well.

“The system allows the wearer to use their preferred gait for each speed,” the team said.

Software excellence translated to performance. A test found that the exosuit reduced the energy for walking by over nine percent and running by four percent. It may not sound like much, but the range of improvement is meaningful in athletic performance. Putting things into perspective, the team said, the metabolic rate reduction during walking is similar to taking 16 pounds off at the waist.

The Wearable Exosuit Revolution
The study’s lightweight exoshorts are hardly the only players in town. Back in 2017, SRI International’s spin-off, Superflex, engineered an Aura suit to support mobility in the elderly. The Aura used a different mechanism: rather than a pulley system, it incorporated a type of smart material that contracts in a manner similar to human muscles when zapped with electricity.

Embedded with a myriad of sensors for motion, accelerometers and gyroscopes, Aura’s smartness came from mini-computers that measure how fast the wearer is moving and track the user’s posture. The data were integrated and processed locally inside hexagon-shaped computing pods near the thighs and upper back. The pods also acted as the control center for sending electrical zaps to give the wearer a boost when needed.

Around the same time, a collaboration between Harvard’s Wyss Institute and ReWalk Robotics introduced a fabric-based wearable robot to assist a wearer’s legs for balance and movement. Meanwhile, a Swiss team coated normal fabric with electroactive material to weave soft, pliable artificial “muscles” that move with the skin.

Although health support is the current goal, the military is obviously interested in similar technologies to enhance soldiers’ physicality. Superflex’s Aura, for example, was originally inspired by technology born from DARPA’s Warrior Web Program, which aimed to reduce a soldier’s mechanical load.

That said, military gear has had a long history of trickling down to consumer use. Similar to the way camouflage, cargo pants, and GORE-TEX trickled down into the consumer ecosphere, it’s not hard to imagine your local Target eventually stocking intelligent exowear.

Image and Video Credit: Wyss Institute at Harvard University. Continue reading

Posted in Human Robots

#435520 These Are the Meta-Trends Shaping the ...

Life is pretty different now than it was 20 years ago, or even 10 years ago. It’s sort of exciting, and sort of scary. And hold onto your hat, because it’s going to keep changing—even faster than it already has been.

The good news is, maybe there won’t be too many big surprises, because the future will be shaped by trends that have already been set in motion. According to Singularity University co-founder and XPRIZE founder Peter Diamandis, a lot of these trends are unstoppable—but they’re also pretty predictable.

At SU’s Global Summit, taking place this week in San Francisco, Diamandis outlined some of the meta-trends he believes are key to how we’ll live our lives and do business in the (not too distant) future.

Increasing Global Abundance
Resources are becoming more abundant all over the world, and fewer people are seeing their lives limited by scarcity. “It’s hard for us to realize this as we see crisis news, but what people have access to is more abundant than ever before,” Diamandis said. Products and services are becoming cheaper and thus available to more people, and having more resources then enables people to create more, thus producing even more resources—and so on.

Need evidence? The proportion of the world’s population living in extreme poverty is currently lower than it’s ever been. The average human life expectancy is longer than it’s ever been. The costs of day-to-day needs like food, energy, transportation, and communications are on a downward trend.

Take energy. In most of the world, though its costs are decreasing, it’s still a fairly precious commodity; we turn off our lights and our air conditioners when we don’t need them (ideally, both to save money and to avoid wastefulness). But the cost of solar energy has plummeted, and the storage capacity of batteries is improving, and solar technology is steadily getting more efficient. Bids for new solar power plants in the past few years have broken each other’s records for lowest cost per kilowatt hour.

“We’re not far from a penny per kilowatt hour for energy from the sun,” Diamandis said. “And if you’ve got energy, you’ve got water.” Desalination, for one, will be much more widely feasible once the cost of the energy needed for it drops.

Knowledge is perhaps the most crucial resource that’s going from scarce to abundant. All the world’s knowledge is now at the fingertips of anyone who has a mobile phone and an internet connection—and the number of people connected is only going to grow. “Everyone is being connected at gigabit connection speeds, and this will be transformative,” Diamandis said. “We’re heading towards a world where anyone can know anything at any time.”

Increasing Capital Abundance
It’s not just goods, services, and knowledge that are becoming more plentiful. Money is, too—particularly money for business. “There’s more and more capital available to invest in companies,” Diamandis said. As a result, more people are getting the chance to bring their world-changing ideas to life.

Venture capital investments reached a new record of $130 billion in 2018, up from $84 billion in 2017—and that’s just in the US. Globally, VC funding grew 21 percent from 2017 to a total of $207 billion in 2018.

Through crowdfunding, any person in any part of the world can present their idea and ask for funding. That funding can come in the form of a loan, an equity investment, a reward, or an advanced purchase of the proposed product or service. “Crowdfunding means it doesn’t matter where you live, if you have a great idea you can get it funded by people from all over the world,” Diamandis said.

All this is making a difference; the number of unicorns—privately-held startups valued at over $1 billion—currently stands at an astounding 360.

One of the reasons why the world is getting better, Diamandis believes, is because entrepreneurs are trying more crazy ideas—not ideas that are reasonable or predictable or linear, but ideas that seem absurd at first, then eventually end up changing the world.

Everyone and Everything, Connected
As already noted, knowledge is becoming abundant thanks to the proliferation of mobile phones and wireless internet; everyone’s getting connected. In the next decade or sooner, connectivity will reach every person in the world. 5G is being tested and offered for the first time this year, and companies like Google, SpaceX, OneWeb, and Amazon are racing to develop global satellite internet constellations, whether by launching 12,000 satellites, as SpaceX’s Starlink is doing, or by floating giant balloons into the stratosphere like Google’s Project Loon.

“We’re about to reach a period of time in the next four to six years where we’re going from half the world’s people being connected to the whole world being connected,” Diamandis said. “What happens when 4.2 billion new minds come online? They’re all going to want to create, discover, consume, and invent.”

And it doesn’t stop at connecting people. Things are becoming more connected too. “By 2020 there will be over 20 billion connected devices and more than one trillion sensors,” Diamandis said. By 2030, those projections go up to 500 billion and 100 trillion. Think about it: there’s home devices like refrigerators, TVs, dishwashers, digital assistants, and even toasters. There’s city infrastructure, from stoplights to cameras to public transportation like buses or bike sharing. It’s all getting smart and connected.

Soon we’ll be adding autonomous cars to the mix, and an unimaginable glut of data to go with them. Every turn, every stop, every acceleration will be a data point. Some cars already collect over 25 gigabytes of data per hour, Diamandis said, and car data is projected to generate $750 billion of revenue by 2030.

“You’re going to start asking questions that were never askable before, because the data is now there to be mined,” he said.

Increasing Human Intelligence
Indeed, we’ll have data on everything we could possibly want data on. We’ll also soon have what Diamandis calls just-in-time education, where 5G combined with artificial intelligence and augmented reality will allow you to learn something in the moment you need it. “It’s not going and studying, it’s where your AR glasses show you how to do an emergency surgery, or fix something, or program something,” he said.

We’re also at the beginning of massive investments in research working towards connecting our brains to the cloud. “Right now, everything we think, feel, hear, or learn is confined in our synaptic connections,” Diamandis said. What will it look like when that’s no longer the case? Companies like Kernel, Neuralink, Open Water, Facebook, Google, and IBM are all investing billions of dollars into brain-machine interface research.

Increasing Human Longevity
One of the most important problems we’ll use our newfound intelligence to solve is that of our own health and mortality, making 100 years old the new 60—then eventually, 120 or 150.

“Our bodies were never evolved to live past age 30,” Diamandis said. “You’d go into puberty at age 13 and have a baby, and by the time you were 26 your baby was having a baby.”

Seeing how drastically our lifespans have changed over time makes you wonder what aging even is; is it natural, or is it a disease? Many companies are treating it as one, and using technologies like senolytics, CRISPR, and stem cell therapy to try to cure it. Scaffolds of human organs can now be 3D printed then populated with the recipient’s own stem cells so that their bodies won’t reject the transplant. Companies are testing small-molecule pharmaceuticals that can stop various forms of cancer.

“We don’t truly know what’s going on inside our bodies—but we can,” Diamandis said. “We’re going to be able to track our bodies and find disease at stage zero.”

Chins Up
The world is far from perfect—that’s not hard to see. What’s less obvious but just as true is that we’re living in an amazing time. More people are coming together, and they have more access to information, and that information moves faster, than ever before.

“I don’t think any of us understand how fast the world is changing,” Diamandis said. “Most people are fearful about the future. But we should be excited about the tools we now have to solve the world’s problems.”

Image Credit: spainter_vfx / Shutterstock.com Continue reading

Posted in Human Robots

#435308 Brain-Machine Interfaces Are Getting ...

Elon Musk grabbed a lot of attention with his July 16 announcement that his company Neuralink plans to implant electrodes into the brains of people with paralysis by next year. Their first goal is to create assistive technology to help people who can’t move or are unable to communicate.

If you haven’t been paying attention, brain-machine interfaces (BMIs) that allow people to control robotic arms with their thoughts might sound like science fiction. But science and engineering efforts have already turned it into reality.

In a few research labs around the world, scientists and physicians have been implanting devices into the brains of people who have lost the ability to control their arms or hands for over a decade. In our own research group at the University of Pittsburgh, we’ve enabled people with paralyzed arms and hands to control robotic arms that allow them to grasp and move objects with relative ease. They can even experience touch-like sensations from their own hand when the robot grasps objects.

At its core, a BMI is pretty straightforward. In your brain, microscopic cells called neurons are sending signals back and forth to each other all the time. Everything you think, do and feel as you interact with the world around you is the result of the activity of these 80 billion or so neurons.

If you implant a tiny wire very close to one of these neurons, you can record the electrical activity it generates and send it to a computer. Record enough of these signals from the right area of the brain and it becomes possible to control computers, robots, or anything else you might want, simply by thinking about moving. But doing this comes with tremendous technical challenges, especially if you want to record from hundreds or thousands of neurons.

What Neuralink Is Bringing to the Table
Elon Musk founded Neuralink in 2017, aiming to address these challenges and raise the bar for implanted neural interfaces.

Perhaps the most impressive aspect of Neuralink’s system is the breadth and depth of their approach. Building a BMI is inherently interdisciplinary, requiring expertise in electrode design and microfabrication, implantable materials, surgical methods, electronics, packaging, neuroscience, algorithms, medicine, regulatory issues, and more. Neuralink has created a team that spans most, if not all, of these areas.

With all of this expertise, Neuralink is undoubtedly moving the field forward, and improving their technology rapidly. Individually, many of the components of their system represent significant progress along predictable paths. For example, their electrodes, that they call threads, are very small and flexible; many researchers have tried to harness those properties to minimize the chance the brain’s immune response would reject the electrodes after insertion. Neuralink has also developed high-performance miniature electronics, another focus area for labs working on BMIs.

Often overlooked in academic settings, however, is how an entire system would be efficiently implanted in a brain.

Neuralink’s BMI requires brain surgery. This is because implanted electrodes that are in intimate contact with neurons will always outperform non-invasive electrodes where neurons are far away from the electrodes sitting outside the skull. So, a critical question becomes how to minimize the surgical challenges around getting the device into a brain.

Maybe the most impressive aspect of Neuralink’s announcement was that they created a 3,000-electrode neural interface where electrodes could be implanted at a rate of between 30 and 200 per minute. Each thread of electrodes is implanted by a sophisticated surgical robot that essentially acts like a sewing machine. This all happens while specifically avoiding blood vessels that blanket the surface of the brain. The robotics and imaging that enable this feat, with tight integration to the entire device, is striking.

Neuralink has thought through the challenge of developing a clinically viable BMI from beginning to end in a way that few groups have done, though they acknowledge that many challenges remain as they work towards getting this technology into human patients in the clinic.

Figuring Out What More Electrodes Gets You
The quest for implantable devices with thousands of electrodes is not only the domain of private companies. DARPA, the NIH BRAIN Initiative, and international consortiums are working on neurotechnologies for recording and stimulating in the brain with goals of tens of thousands of electrodes. But what might scientists do with the information from 1,000, 3,000, or maybe even 100,000 neurons?

At some level, devices with more electrodes might not actually be necessary to have a meaningful impact in people’s lives. Effective control of computers for access and communication, of robotic limbs to grasp and move objects as well as of paralyzed muscles is already happening—in people. And it has been for a number of years.

Since the 1990s, the Utah Array, which has just 100 electrodes and is manufactured by Blackrock Microsystems, has been a critical device in neuroscience and clinical research. This electrode array is FDA-cleared for temporary neural recording. Several research groups, including our own, have implanted Utah Arrays in people that lasted multiple years.

Currently, the biggest constraints are related to connectors, electronics, and system-level engineering, not the implanted electrode itself—although increasing the electrodes’ lifespan to more than five years would represent a significant advance. As those technical capabilities improve, it might turn out that the ability to accurately control computers and robots is limited more by scientists’ understanding of what the neurons are saying—that is, the neural code—than by the number of electrodes on the device.

Even the most capable implanted system, and maybe the most capable devices researchers can reasonably imagine, might fall short of the goal of actually augmenting skilled human performance. Nevertheless, Neuralink’s goal of creating better BMIs has the potential to improve the lives of people who can’t move or are unable to communicate. Right now, Musk’s vision of using BMIs to meld physical brains and intelligence with artificial ones is no more than a dream.

So, what does the future look like for Neuralink and other groups creating implantable BMIs? Devices with more electrodes that last longer and are connected to smaller and more powerful wireless electronics are essential. Better devices themselves, however, are insufficient. Continued public and private investment in companies and academic research labs, as well as innovative ways for these groups to work together to share technologies and data, will be necessary to truly advance scientists’ understanding of the brain and deliver on the promise of BMIs to improve peoples’ lives.

While researchers need to keep the future societal implications of advanced neurotechnologies in mind—there’s an essential role for ethicists and regulation—BMIs could be truly transformative as they help more people overcome limitations caused by injury or disease in the brain and body.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Image Credit: UPMC/Pitt Health Sciences, / CC BY-NC-ND Continue reading

Posted in Human Robots